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Enzymes
  Enzyme classes:
  EC 1: Oxidoreductases
  EC 2: Transferases
  EC 3: Hydrolases
    EC 3.1
    EC 3.2
    EC 3.3
    EC 3.4
    EC 3.5
    EC 3.6
    EC 3.7
    EC 3.8
    EC 3.9
    EC 3.10
    EC 3.11
    EC 3.12
    EC 3.13
  EC 4: Lyases
  EC 5: Isomerases
  EC 6: Ligases
  General information:
  Catalytic mechanism
  Enzyme kinetics
  Inhibitors
  Enzymes in industry

EC 3. Hydrolase, Nomenclature

Hydrolase definition and nomenclature

According to the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB) classification, EC 3 hydrolases are enzymes that catalyse hydrolysis of various covalent bonds. Due to low specificity of many hydrolases it is very difficult to make a unambiguous classification of these enzymes. Furthermore, previously studied and classified hydrolases should be revised in order to avoid duplication of some of them. The classical name is formed by the name of the substrate with an additional suffix -ase.

EC 3 number classification of Oxidoreductases

This classification is based on substrates hydrolysed by enzymes.

EC 3.1 - Hydrolyse an ester bonds.
EC 3.2 - Glycosylases, hydrolyse sugar compounds and also some of them can also transfer glycosyl residues to alcoholic acceptors.
EC 3.3 - Hydrolyse ether bonds.
EC 3.4 - Peptidases or peptide hydrolases. Hydrolyse peptide bonds.
EC 3.5 - Hydrolyse a Carbon-Nitrogen bonds except peptide bonds.
EC 3.6 - Hydrolyse an acid anhydrides.
EC 3.7 - Hydrolyse a Carbon-Carbon bonds.
EC 3.8 - Hydrolyse a Halide bonds from organic halides.
EC 3.9 - Hydrolyse a Phosphorus-Nitrogen bond. Phosphoamidase group.
EC 3.10 - Hydrolyse a Sulphur-Nitrogen bond.
EC 3.11 - Hydrolyse a Carbon-Phosphorus bond in C-phosphono groups.
EC 3.12 - Hydrolyse a Sulphur-Sulphur bonds.
EC 3.13 - Hydrolyse a Carbon-Sulphur bonds.