EC 5.99.1.3 - DNA topoisomerase (ATP- hydrolysing)

3D structures of EC 5.99.1.3 - DNA topoisomerase (ATP-hydrolysing) in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1ab4: 59kda Fragment of Gyrase a from E. Coli
2. 1aj6: Novobiocin-resistant Mutant (R136H) of The N-terminal 24 Kda Fragment of Dna Gyrase B Complexed with Novobiocin at 2.3 Angstroms Resolution
3. 1bjt: Topoisomerase II Residues 409-1201
4. 1d3y: Structure of The Dna Topoisomerase VI a Subunit
5. 1ei1: Dimerization of E. Coli Dna Gyrase B Provides a Structural Mechanism for Activating The Atpase Catalytic Center
6. 1kij: Crystal Structure of The 43k Atpase Domain of Thermus Thermophilus Gyrase B in Complex with Novobiocin
7. 1kzn: Crystal Structure of E. Coli 24kda Domain in Complex with Clorobiocin
8. 3nuh: A Domain Insertion in E. Coli Gyrb Adopts a Novel Fold That Plays a Critical Role in Gyrase Function
9. 3no0: Aquifex Aeolicus Type Iia Topoisomerase C-terminal Domain
10. 1mu5: Structure of Topoisomerase Subunit
11. 1mx0: Structure of Topoisomerase Subunit
12. 3m4i: Crystal Structure of The Second part of The Mycobacterium Tuberculosis Dna Gyrase Reaction Core: The Toprim Domain at 1.95 a Resolution
13. 3l6v: Crystal Structure of The Xanthomonas Campestris Gyrase a C- Terminal Domain
14. 3l4k: Topoisomerase Ii-dna Cleavage Complex, Metal-bound
15. 3l4j: Topoisomerase Ii-dna Cleavage Complex, Apo
16. 3ilw: Structure of Dna Gyrase Subunit a N-terminal Domain
17. 3ig0: Crystal Structure of The Second part of The Mycobacterium Tuberculosis Dna Gyrase Reaction Core: The Toprim Domain at 2.1 a Resolution
18. 3ifz: Crystal Structure of The First part of The Mycobacterium Tuberculosis Dna Gyrase Reaction Core: The Breakage and Reunion Domain at 2.7 a Resolution
19. 1pvg: Crystal Structure of The Atpase Region of Saccharomyces Cerevisiae Topoisomerase II
20. 1qzr: Crystal Structure of The Atpase Region of Saccharomyces Cerevisiae Topoisomerase II Bound to Icrf-187 (dexrazoxane)
21. 3g7e: Crystal Structure of E. Coli Gyrase B Co-complexed with Inhibitor
22. 3g7b: Staphylococcus Aureus Gyrase B Co-complex with Inhibitor
23. 3g75: Crystal Structure of Staphylococcus Aureus Gyrase B Co- Complexed with Inhibitor
24. 1suu: Structure of Dna Gyrase a C-terminal Domain
25. 2zjt: Crystal Structure of Dna Gyrase B' Domain Sheds Lights on The Mechanism for T-segment Navigation
26. 2zbk: Crystal Structure of an Intact Type II Dna Topoisomerase: Insights into Dna Transfer Mechanisms
27. 1x75: Ccdb:gyra14 Complex
28. 2xct: The Twinned 3.35a Structure of S. Aureus Gyrase Complex with Ciprofloxacin and Dna
29. 2xcs: The 2.1a Crystal Structure of S. Aureus Gyrase Complex with Gsk299423 and Dna
30. 2xcr: The 3.5a Crystal Structure of The Catalytic Core (b'a' Region) of Staphylococcus Aureus Dna Gyrase Complexed with Gsk299423 and Dna
31. 2xcq: The 2.98a Crystal Structure of The Catalytic Core (b'a' Region) of Staphylococcus Aureus Dna Gyrase
32. 2xco: The 3.1a Crystal Structure of The Catalytic Core (b'a' Region) of Staphylococcus Aureus Dna Gyrase
33. 1z59: Topoisomerase Vi-b, Adp-bound Monomer Form
34. 1z5a: Topoisomerase Vi-b, Adp-bound Dimer Form
35. 1z5b: Topoisomerase Vi-b, Adp Alf4- Bound Dimer Form
36. 1z5c: Topoisomerase Vi-b, Adp Pi Bound Dimer Form
37. 1zi0: A Superhelical Spiral in Escherichia Coli Dna Gyrase a C- Terminal Domain Imparts Unidirectional Supercoiling Bias
38. 1zxm: Human Topo Iia Atpase/amp-pnp
39. 1zxn: Human Dna Topoisomerase Iia Atpase/adp
40. 2rgr: Topoisomerase Iia Bound to G-segment Dna
41. 2q2e: Crystal Structure of The Topoisomerase VI Holoenzyme from Methanosarcina Mazei
42. 6bq9: 2.55 Angstrom Resolution Crystal Structure of N-terminal Fragment (residues 1-493) of Dna Topoisomerase IV Subunit a from Pseudomonas Putida
43. 5zxm: Crystal Structure of Gyraseb N-terminal at 1.93a Resolution
44. 5ztj: Crystal Structure of Gyrasea C-terminal Domain from Salmonella Typhi at 2.4a Resolution
45. 5zrf: Crystal Structure of Human Topoisomerase II Beta in Complex with 5- Iodouridine-containing-dna and Etoposide in Space Group P21
46. 5zqf: Crystal Structure of Human Topoisomerase II Beta in Complex with 5- Iodouridine-containing-dna in Space Group P3221
47. 5zen: Crystal Structure of Human Topoisomerase II Beta in Complex with Dna: a New Quaternary Conformation Showing Opening of The Protein-linked Dna-gate
48. 5zad: Human Topoisomerase II Beta in Complex with Dna
49. 5z9q: Bacterial Gyrb Atpase Domain in Complex with a Chemical Fragment
50. 5z9p: Bacterial Gyrb Atpase Domain in Complex with a Chemical Fragment
51. 5z9n: S.aureus Gyrb Atpase Domain in Complex with 4,6-dichloro-2- (methylthio)pyrimidine
52. 5z9m: Bacterial Gyrb Atpase Domain in Complex with a Chemical Fragment
53. 5z9l: Bacterial Gyrb Atpase Domain in Complex with a Chemical Fragment
54. 5z9f: Bacterial Gyrb Atpase Domain in Complex with a Chemical Fragment
55. 5z9e: Bacterial Gyrb Atpase Domain in Complex with a Chemical Fragment
56. 5z9b: Bacterial Gyrb Atpase Domain in Complex with (3,4-dichlorophenyl) Hydrazine
57. 5z4o: Bacterial Gyrb Atpase Domain in Complex with a Chemical Fragment
58. 5z4h: Bacterial Gyrb Atpase Domain in Complex with a Chemical Fragment
59. 2hkj: Topoisomerase Vi-b Bound to Radicicol
60. 2y3p: Crystal Structure of N-terminal Domain of Gyra with The Antibiotic Simocyclinone D8
61. 3lnu: Crystal Structure of Pare Subunit
62. 3lps: Crystal Structure of Pare
63. 3lpx: Crystal Structure of Gyra
64. 3qx3: Human Topoisomerase Iibeta in Complex with Dna and Etoposide
65. 6rks: E. Coli Dna Gyrase - Dna Binding and Cleavage Domain in State 1 without Toprim Insertion
66. 3ttz: Crystal Structure of a Topoisomerase Atpase Inhibitor
67. 6qx2: 3.4a Structure of Benzoisoxazole 3 with S.aureus Dna Gyrase and Dna
68. 6qx1: 2.7a Structure of Benzoisoxazole 3 with S.aureus Dna Gyrase and Dna.
69. 6qtp: 2.37a Structure of Gepotidacin with S.aureus Dna Gyrase and Uncleaved Dna
70. 6qtk: 2.31a Structure of Gepotidacin with S.aureus Dna Gyrase and Doubly Nicked Dna
71. 3u2d: S. Aureus Gyrb Atpase Domain in Complex with Small Molecule Inhibitor
72. 3u2k: S. Aureus Gyrb Atpase Domain in Complex with a Small Molecule Inhibitor
73. 3uc1: Mycobacterium Tuberculosis Gyrase Type Iia Topoisomerase C-terminal Domain
74. 4ely: CCDBVFI:GYRA14EC
75. 4elz: CCDBVFI:GYRA14VFI
76. 6n1r: Tetrahedral Oligomeric Complex of Gyra N-terminal Fragment, Solved by Cryoem in Tetrahedral Symmetry
77. 6n1q: Dihedral Oligomeric Complex of Gyra N-terminal Fragment, Solved by Cryoem in D2 Symmetry
78. 6n1p: Dihedral Oligomeric Complex of Gyra N-terminal Fragment with Dna, Solved by Cryoem in C2 Symmetry
79. 4duh: Crystal Structure of 24 Kda Domain of E. Coli Dna Gyrase B in Complex with Small Molecule Inhibitor
80. 4fm9: Human Topoisomerase II Alpha Bound to Dna
81. 4gfh: Topoisomerase Ii-dna-amppnp Complex
82. 4b6c: Structure of The M. Smegmatis Gyrb Atpase Domain in Complex with an Aminopyrazinamide
83. 4ddq: Structural Plasticity of The Bacillus Subtilis Gyra Homodimer
84. 4ddt: Thermotoga Maritima Reverse Gyrase, C2 Form 2
85. 4ddu: Thermotoga Maritima Reverse Gyrase, C2 Form 1
86. 4ddv: Thermotoga Maritima Reverse Gyrase, Triclinic Form
87. 4ddw: Thermotoga Maritima Reverse Gyrase, C-centered Orthorhombic Form
88. 4ddx: Thermotoga Maritima Reverse Gyrase, Primitive Monoclinic Form
89. 4gee: Pyrrolopyrimidine Inhibitors of Dna Gyrase B and Topoisomerase Iv, part I: Structure Guided Discovery and Optimization of Dual Targeting Agents with Potent, Broad-spectrum Enzymatic Activity.
90. 4gfn: Pyrrolopyrimidine Inhibitors of Dna Gyrase B and Topoisomerase Iv, part I: Structure Guided Discovery and Optimization of Dual Targeting Agents with Potent, Broad-spectrum Enzymatic
91. 4ggl: Pyrrolopyrimidine Inhibitors of Dna Gyrase B and Topoisomerase Iv, part I: Structure Guided Discovery and Optimization of Dual Targeting Agents with Potent, Broad-spectrum Enzymatic Activity
92. 4hxw: Pyrrolopyrimidine Inhibitors of Dna Gyrase B and Topoisomerase Iv, part I: Structure Guided Discovery and Optimization of Dual Targeting Agents with Potent, Broad-spectrum Enzymatic Activity.
93. 4hxz: Pyrrolopyrimidine Inhibitors of Dna Gyrase B and Topoisomerase Iv, part I: Structure Guided Discovery and Optimization of Dual Targeting Agents with Potent, Broad-spectrum Enzymatic Activity.
94. 4hy1: Pyrrolopyrimidine Inhibitors of Dna Gyrase B and Topoisomerase Iv, part I: Structure Guided Discovery and Optimization of Dual Targeting Agents with Potent, Broad-spectrum Enzymatic Activity.
95. 4hym: Pyrrolopyrimidine Inhibitors of Dna Gyrase B and Topoisomerase Iv, part I: Structure Guided Discovery and Optimization of Dual Targeting Agents with Potent, Broad-spectrum Enzymatic Activity.
96. 4hyp: Pyrrolopyrimidine Inhibitors of Dna Gyrase B and Topoisomerase Iv, part I: Structure Guided Discovery and Optimization of Dual Targeting Agents with Potent, Broad-spectrum Enzymatic Activity.
97. 6gav: Extremely 'open' Clamp Structure of Dna Gyrase: Role of The Corynebacteriales Gyrb Specific Insert
98. 6gau: Extremely 'open' Clamp Structure of Dna Gyrase: Role of The Corynebacteriales Gyrb Specific Insert
99. 6fqv: 2.60a Binary Complex of S.aureus Gyrase with Uncleaved Dna
100. 6fqs: 3.11a Complex of S.aureus Gyrase with Imidazopyrazinone T3 and Dna
101. 6fqm: 3.06a Complex of S.aureus Gyrase with Imidazopyrazinone T1 and Dna
102. 6fm4: The Crystal Structure of S. Aureus Gyrase Complex with Id-130 and Dna
103. 6f96: Crystal Structure of E. Coli Gyraseb 24kda in Complex with 6- [(ethylcarbamoyl)amino]-4-[(4-methoxyphenyl)amino]-n-(pyridin-3-yl) Pyridine-3-carboxamide
104. 6f94: Crystal Structure of E. Coli Gyraseb 24kda in Complex with 6- [(ethylcarbamoyl)amino]-4-[(3-methyphenyl)amino]-n-(3-methyphenyl) Pyridine-3-carboxamide
105. 6f8j: Crystal Structure of E. Coli Gyraseb 24kda in Complex with 6- [(ethylcarbamoyl)amino]-4-(1h-pyrazol-1-yl)-n-(pyridin-3-yl)pyridine- 3-carboxamide
106. 6f86: Crystal Structure of E. Coli Gyraseb 24kda in Complex with 4-(4-bromo- 1h-pyrazol-1-yl)-6-[(ethylcarbamoyl)amino]-n-(pyridin-3-yl)pyridine- 3-carboxamide
107. 4g0u: Human Topoisomerase Iibeta in Complex with Dna and Amsacrine
108. 4g0v: Human Topoisomerase Iibeta in Complex with Dna and Mitoxantrone
109. 4g0w: Human Topoisomerase Iibeta in Complex with Dna and Ametantrone
110. 6enh: Crystal Structure of The 43k Atpase Domain of Thermus Thermophilus Gyrase B in Complex with an Aminocoumarin
111. 6eng: Crystal Structure of The 43k Atpase Domain of Escherichia Coli Gyrase B in Complex with an Aminocoumarin
112. 4bul: Novel Hydroxyl Tricyclics (e.g. Gsk966587) as Potent Inhibitors of Bacterial Type Iia Topoisomerases
113. 4g3n: Mycobacterium Tuberculosis Gyrase Type Iia Topoisomerase C-terminal Domain at 1.4 a Resolution
114. 3zkb: Crystal Structure of The Atpase Region of Mycobacterium Tuberculosis Gyrb with Amppnp
115. 3zkd: Crystal Structure of The Atpase Region of Mycobacterium Tuberculosis Gyrb with Amppnp
116. 3zm7: Crystal Structure of The Atpase Region of Mycobacterium Tuberculosis Gyrb with Amppcp
117. 4bae: Optimisation of Pyrroleamides as Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in The Mouse Model of Tuberculosis
118. 6ca8: Crystal Structure of Plasmodium Falciparum Topoisomerase II Dna- Binding, Cleavage and Re-ligation Domain
119. 4ckk: Apo Structure of 55 Kda N-terminal Domain of E. Coli Dna Gyrase a Subunit
120. 4ckl: Structure of 55 Kda N-terminal Domain of E. Coli Dna Gyrase a Subunit with Simocyclinone D8 Bound
121. 4i3h: A Three-gate Structure of Topoisomerase IV from Streptococcus Pneumoniae
122. 4j3n: Human Topoisomerase Iibeta in Complex with Dna
123. 4juo: A Low-resolution Three-gate Structure of Topoisomerase IV from Streptococcus Pneumoniae in Space Group H32
124. 4k4o: The Dna Gyrase B Atp Binding Domain of Enterococcus Faecalis in Complex with a Small Molecule Inhibitor
125. 4kfg: The Dna Gyrase B Atp Binding Domain of Escherichia Coli in Complex with a Small Molecule Inhibitor.
126. 4kqv: Topoisomerase IV Atp Binding Domain of Francisella Tularensis in Complex with a Small Molecule Inhibitor
127. 4ksg: Dna Gyrase Atp Binding Domain of Enterococcus Faecalis in Complex with a Small Molecule Inhibitor (4-[(1s,5r,6r)-6-amino-1-methyl-3- Azabicyclo[3.2.0]hept-3-yl]-6-fluoro-n-methyl-2-[(2-methylpyrimidin- 5-yl)oxy]-9h-pyrimido[4,5-b]indol-8-amine)
128. 4ksh: Dna Gyrase Atp Binding Domain of Enterococcus Faecalis in Complex with a Small Molecule Inhibitor (7-({4-[(3r)-3-aminopyrrolidin-1-yl]-5- Chloro-6-ethyl-7h-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)-1,5- Naphthyridin-1(4h)-ol)
129. 4ktn: Dna Gyrase Atp Binding Domain of Enterococcus Faecalis in Complex with a Small Molecule Inhibitor ((3s)-1-[2-(pyrido[2,3-b]pyrazin-7- Ylsulfanyl)-9h-pyrimido[4,5-b]indol-4-yl]pyrrolidin-3-amine)
130. 4lpb: Crystal Structure of a Topoisomerase Atpase Inhibitor
131. 4mn4: Structural Basis for The Mukb-topoisomerase IV Interaction
132. 4oz6: Structure of The Branched Intermediate in Protein Splicing
133. 5yig: Crystal Structure of Streptococcus Pneumonia Pare with Inhibitor
134. 4p8o: S. Aureus Gyrase Bound to an Aminobenzimidazole Urea Inhibitor
135. 4plb: Crystal Structure of S.a. Gyrase-am8191 Complex
136. 4prv: E. Coli Gyrb 43-kda N-terminal Fragment in Complex with Adp
137. 4prx: E. Coli Gyrb 43-kda N-terminal Fragment in Complex with Adp+pi
138. 4pu9: E. Coli Gyrb 43-kda N-terminal Fragment in Complex with Adp-bef3
139. 4r1f: Re-refined Human Dna Topoisomerase Iia (atpase and Transducer Domains) in Complex with Adp and So4
140. 4tma: Crystal Structure of Gyrase Bound to Its Inhibitor Yacg
141. 6j90: Crystal Structure of Gyraseb N-terminal Domain Complex with Atp from Salmonella Typhi at 2.2a Resolution
142. 4urm: Crystal Structure of Staph Gyraseb 24kda in Complex with Kibdelomycin
143. 4uro: Crystal Structure of Staph Gyraseb 24kda in Complex with Novobiocin
144. 4koe: Quinolone(trovafloxacin)-dna Cleavage Complex of Type IV Topoisomerase from S. Pneumoniae
145. 4kpe: Novel Fluoroquinolones in Complex with Topoisomerase IV from S. Pneumoniae and E-site G-gate
146. 5npp: 2.22a Structure of Thiophene2 and Gsk945237 with S.aureus Dna Gyrase and Dna
147. 5npk: 1.98a Structure of Thiophene1 with S.aureus Dna Gyrase and Dna
148. 5mmp: E. Coli Dna Gyrase B 24 Kda Atpase Domain in Complex with 1-ethyl-3- [5-pyridin-4-yl-8-(pyridin-3-ylamino)-isoquinolin-3-yl]-urea
149. 5mmo: E. Coli Dna Gyrase B 24 Kda Atpase Domain in Complex with [3-(3-ethyl- Ureido)-5-(pyridin-4-yl)-isoquinolin-8-yl-methyl]-carbamic Acid Prop- 2-ynyl Ester
150. 5mmn: E. Coli Dna Gyrase B 24 Kda Atpase Domain in Complex with 1-ethyl-3- [8-methyl-5-(2-methyl-pyridin-4-yl)-isoquinolin-3-yl]-urea
151. 5l3j: Escherichia Coli Dna Gyrase B in Complex with Benzothiazole-based Inhibitor
152. 5j5q: Amp-pnp-stabilized Atpase Domain of Topoisomerase IV from Streptococcus Pneumoniae, Complex Type II
153. 5j5p: Amp-pnp-stabilized Atpase Domain of Topoisomerase IV from Streptococcus Pneumoniae, Complex Type I
154. 5iwm: 2.5a Structure of Gsk945237 with S.aureus Dna Gyrase and Dna.
155. 5iwi: 1.98a Structure of Gsk945237 with S.aureus Dna Gyrase and Singly Nicked Dna
156. 5gwk: Human Topoisomerase Iialpha in Complex with Dna and Etoposide
157. 5gwj: Structure of a Human Topoisomerase Iibeta Fragment in Complex with Dna and E7873S
158. 5gwi: Structure of a Human Topoisomerase Iibeta Fragment in Complex with Dna and E7873R
159. 5eix: Quinolone-stabilized Cleavage Complex of Topoisomerase IV from Klebsiella Pneumoniae
160. 5d7r: Crystal Structure of The Atp Binding Domain of S. Aureus Gyrb Complexed with a Ligand
161. 5d7d: Crystal Structure of The Atp Binding Domain of S. Aureus Gyrb Complexed with a Ligand
162. 5d7c: Crystal Structure of The Atp Binding Domain of S. Aureus Gyrb Complexed with a Ligand
163. 5d6q: Crystal Structure of The Atp Binding Domain of S. Aureus Gyrb Complexed with a Ligand
164. 5d6p: Crystal Structure of The Atp Binding Domain of S. Aureus Gyrb Complexed with a Ligand
165. 5cty: Crystal Structure of The Atp Binding Domain of S. Aureus Gyrb Complexed with a Fragment
166. 5ctx: Crystal Structure of The Atp Binding Domain of S. Aureus Gyrb Complexed with a Fragment
167. 5ctw: Crystal Structure of The Atp Binding Domain of S. Aureus Gyrb Complexed with a Fragment
168. 5ctu: Crystal Structure of The Atp Binding Domain of S. Aureus Gyrb Complexed with a Fragment
169. 5cph: Crystal Structure of The Atp Binding Domain of S. Aureus Gyrb Complexed with a Fragment
170. 5cdr: 2.65 Structure of S.aureus Dna Gyrase and Artificially Nicked Dna
171. 5cdq: 2.95a Structure of Moxifloxacin with S.aureus Dna Gyrase and Dna
172. 5cdp: 2.45a Structure of Etoposide with S.aureus Dna Gyrase and Dna
173. 5cdo: 3.15a Structure of Qpt-1 with S.aureus Dna Gyrase and Dna
174. 5cdn: 2.8a Structure of Etoposide with S.aureus Dna Gyrase and Dna
175. 5cdm: 2.5a Structure of Qpt-1 with S.aureus Dna Gyrase and Dna
176. 5btn: Crystal Structure of a Topoisomerase II Complex
177. 5btl: Crystal Structure of a Topoisomerase II Complex
178. 5bti: Crystal Structure of a Topoisomerase II Complex
179. 5btg: Crystal Structure of a Topoisomerase II Complex
180. 5btf: Crystal Structure of a Topoisomerase II Complex
181. 5btd: Crystal Structure of a Topoisomerase II Complex
182. 5btc: Crystal Structure of a Topoisomerase II Complex
183. 5bta: Crystal Structure of a Topoisomerase II Complex
184. 5bs8: Crystal Structure of a Topoisomerase II Complex
185. 5bs3: Crystal Structure of S.a. Gyrase in Complex with Compound 7
186. 5bod: Crystal Structure of Streptococcus Pneumonia Pare Inhibitor
187. 5boc: Crystal Structure of Topoisomerase Pare Inhibitor
188. 4zvi: Gyrase B in Complex with 4,5-dibromopyrrolamide-based Inhibitor
189. 4z53: Quinolone(trovafloxacin)-dna Cleavage Complex of Topoisomerase IV from S. Pneumoniae
190. 4z4q: Quinazolinedione(pd 0305970)-dna Cleavage Complex of Topoisomerase IV from S. Pneumoniae
191. 4z3o: Quinolone(moxifloxacin)-dna Cleavage Complex of Topoisomerase IV from S. Pneumoniae
192. 4z2e: Quinolone(trovafloxacin)-dna Cleavage Complex of Gyrase from S. Pneumoniae
193. 4z2d: Quinolone(levofloxacin)-dna Cleavage Complex of Gyrase from S. Pneumoniae
194. 4z2c: Quinolone(moxifloxacin)-dna Cleavage Complex of Gyrase from S. Pneumoniae
195. 4wub: N-terminal 43 Kda Fragment of The E. Coli Dna Gyrase B Subunit Grown from 100 Mm Kcl Condition
196. 4wuc: N-terminal 43 Kda Fragment of The E. Coli Dna Gyrase B Subunit Grown from 100 Mm Nacl Condition
197. 4wud: N-terminal 43 Kda Fragment of The E. Coli Dna Gyrase B Subunit Grown from No Salt Condition
198. 4xtj: N-terminal 43 Kda Fragment of The E. Coli Dna Gyrase B Subunit Grown from 100 Mm Kcl plus 100 Mm Nacl Condition
199. 6zt3: N-terminal 47 Kda Fragment of The Mycobacterium Smegmatis Dna Gyrase B Subunit Complexed with Adpnp