EC 2.1.3.2 - carbamoyl- phosphate:L- aspartate carbamoyltransferase

3D structures of EC 2.1.3.2 - aspartate carbamoyltransferase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1acm: Arginine 54 in The Active Site of Escherichia Coli Aspartate Transcarbamoylase Is Critical for Catalysis: a Site-specific Mutagenesis, Nmr and X-ray Crystallography Study
2. 1at1: Crystal Structures of Phosphonoacetamide Ligated T and Phosphonoacetamide and Malonate Ligated R States of Aspartate Carbamoyltransferase at 2.8-angstroms Resolution and Neutral P*h
3. 1d09: Aspartate Transcarbamoylase Complexed with N-phosphonacetyl- L-aspartate (pala)
4. 1ekx: The Isolated, Unregulated Catalytic Trimer of Aspartate Transcarbamoylase Complexed with Bisubstrate Analog Pala (n-(phosphonacetyl)-l-aspartate)
5. 1ezz: Crystal Structure of E. Coli Aspartate Transcarbamoylase P268A Mutant in The T-state
6. 1f1b: Crystal Structure of E. Coli Aspartate Transcarbamoylase P268A Mutant in The R-state in The Presence of N- Phosphonacetyl-l-aspartate
7. 1i5o: Crystal Structure of Mutant R105A of E. Coli Aspartate Transcarbamoylase
8. 9atc: Atcase Y165F Mutant
9. 8atc: Complex of N-phosphonacetyl-l-aspartate with Aspartate Carbamoyltransferase. X-ray Refinement, Analysis of Conformational Changes and Catalytic and Allosteric Mechanisms
10. 8at1: Crystal Structures of Aspartate Carbamoyltransferase Ligated with Phosphonoacetamide, Malonate, and Ctp or Atp at 2.8-angstroms Resolution and Neutral P*h
11. 7at1: Crystal Structures of Aspartate Carbamoyltransferase Ligated with Phosphonoacetamide, Malonate, and Ctp or Atp at 2.8-angstroms Resolution and Neutral P*h
12. 6at1: Structural Consequences of Effector Binding to The T State of Aspartate Carbamoyltransferase. Crystal Structures of The Unligated and Atp-, and Ctp-complexed Enzymes at 2.6- Angstroms Resolution
13. 5at1: Structural Consequences of Effector Binding to The T State of Aspartate Carbamoyltransferase. Crystal Structures of The Unligated and Atp-, and Ctp-complexed Enzymes at 2.6- Angstroms Resolution
14. 4at1: Structural Consequences of Effector Binding to The T State of Aspartate Carbamoyltransferase. Crystal Structures of The Unligated and Atp-, and Ctp-complexed Enzymes at 2.6- Angstroms Resolution
15. 6jkq: Crystal Structure of Aspartate Transcarbamoylase from Trypanosoma Cruzi (ligand-free Form)
16. 1ml4: The Pala-liganded Aspartate Transcarbamoylase Catalytic Subunit from Pyrococcus Abyssi
17. 3mpu: Crystal Structure of The C47A/A241C Disulfide-linked E. Coli Aspartate Transcarbamoylase Holoenzyme
18. 3lxm: 2.00 Angstrom Resolution Crystal Structure of a Catalytic Subunit of an Aspartate Carbamoyltransferase (pyrb) from Yersinia Pestis Co92
19. 1nbe: Aspartate Transcarbomylase Regulatory Chain Mutant (T82A)
20. 1pg5: Crystal Structure of The Unligated (t-state) Aspartate Transcarbamoylase from The Extremely Thermophilic Archaeon Sulfolobus Acidocaldarius
21. 6jkt: Crystal Structure of Aspartate Transcarbamoylase from Trypanosoma Cruzi in Complex with N-(phosphonacetyl)-l-aspartic Acid (pala).
22. 1q95: Aspartate Transcarbamylase (atcase) of Escherichia Coli: a New Crystalline R State Bound to Pala, or to Product Analogues Phosphate and Citrate
23. 1r0b: Aspartate Transcarbamylase (atcase) of Escherichia Coli: a New Crystalline R State Bound to Pala, or to Product Analogues Phosphate and Citrate
24. 1r0c: Products in The T State of Aspartate Transcarbamylase: Crystal Structure of The Phosphate and N-carbamyl-l- Aspartate Ligated Enzyme
25. 1raa: Crystal Structure of Ctp-ligated T State Aspartate Transcarbamoylase at 2.5 Angstroms Resolution: Implications for Atcase Mutants and The Mechanism of Negative Cooperativity
26. 1rab: Crystal Structure of Ctp-ligated T State Aspartate Transcarbamoylase at 2.5 Angstroms Resolution: Implications for Atcase Mutants and The Mechanism of Negative Cooperativity
27. 1rac: Crystal Structure of Ctp-ligated T State Aspartate Transcarbamoylase at 2.5 Angstroms Resolution: Implications for Atcase Mutants and The Mechanism of Negative Cooperativity
28. 1rad: Crystal Structure of Ctp-ligated T State Aspartate Transcarbamoylase at 2.5 Angstroms Resolution: Implications for Atcase Mutants and The Mechanism of Negative Cooperativity
29. 1rae: Crystal Structure of Ctp-ligated T State Aspartate Transcarbamoylase at 2.5 Angstroms Resolution: Implications for Atcase Mutants and The Mechanism of Negative Cooperativity
30. 1raf: Crystal Structure of Ctp-ligated T State Aspartate Transcarbamoylase at 2.5 Angstroms Resolution: Implications for Atcase Mutants and The Mechanism of Negative Cooperativity
31. 1rag: Crystal Structure of Ctp-ligated T State Aspartate Transcarbamoylase at 2.5 Angstroms Resolution: Implications for Atcase Mutants and The Mechanism of Negative Cooperativity
32. 1rah: Crystal Structure of Ctp-ligated T State Aspartate Transcarbamoylase at 2.5 Angstroms Resolution: Implications for Atcase Mutants and The Mechanism of Negative Cooperativity
33. 1rai: Crystal Structure of Ctp-ligated T State Aspartate Transcarbamoylase at 2.5 Angstroms Resolution: Implications for Atcase Mutants and The Mechanism of Negative Cooperativity
34. 6jl4: Crystal Structure of Aspartate Transcarbamoylase from Trypanosoma Cruzi in Complex with Carbamoyl Aspartate (ca) and Phosphate (pi)
35. 1sku: E. Coli Aspartate Transcarbamylase 240's Loop Mutant (K244N)
36. 3e2p: Catalytic Subunit of M. Jannaschii Aspartate Transcarbamoylase in an Orthorhombic Crystal Form
37. 1tth: Aspartate Transcarbamoylase Catalytic Chain Mutant GLU50ALA Complexed with N-(phosphonacetyl-l-aspartate) (pala)
38. 1tu0: Aspartate Transcarbamoylase Catalytic Chain Mutant E50A Complex with Phosphonoacetamide
39. 1tug: Aspartate Transcarbamoylase Catalytic Chain Mutant E50A Complex with Phosphonoacetamide, Malonate, and Cytidine-5- Prime-triphosphate (ctp)
40. 3d7s: Crystal Structure of Wild-type E. Coli Asparate Transcarbamoylase at Ph 8.5 at 2.80 a Resolution
41. 3d6n: Crystal Structure of Aquifex Dihydroorotase Activated by Aspartate Transcarbamoylase
42. 3csu: Catalytic Trimer of Escherichia Coli Aspartate Transcarbamoylase
43. 3at1: Crystal Structures of Phosphonoacetamide Ligated T and Phosphonoacetamide and Malonate Ligated R States of Aspartate Carbamoyltransferase at 2.8-angstroms Resolution and Neutral Ph
44. 6kj8: E. Coli Atcase Holoenzyme Mutant - G166P (catalytic Chain)
45. 6kj9: E. Coli Atcase Catalytic Subunit Mutant - G128/130a
46. 1xjw: The Structure of E. Coli Aspartate Transcarbamoylase Q137A Mutant in The R-state
47. 1za1: Structure of Wild-type E. Coli Aspartate Transcarbamoylase in The Presence of Ctp at 2.20 a Resolution
48. 1za2: Structure of Wild-type E. Coli Aspartate Transcarbamoylase in The Presence of Ctp, Carbamoyl Phosphate at 2.50 a Resolution
49. 2a0f: Structure of D236A Mutant E. Coli Aspartate Transcarbamoylase in Presence of Phosphonoacetamide at 2.90 a Resolution
50. 7k46: Crystal Structure of a Putative Aspartate Carbamoyltransferase Leishmania Major Friedlin
51. 2air: T-state Active Site of Aspartate Transcarbamylase:crystal Structure of The Carbamyl Phosphate and L-alanosine Ligated Enzyme
52. 2at1: Crystal Structures of Phosphonoacetamide Ligated T and Phosphonoacetamide and Malonate Ligated R States of Aspartate Carbamoyltransferase at 2.8-angstroms Resolution and Neutral Ph
53. 2at2: Molecular Structure of Bacillus Subtilis Aspartate Transcarbamoylase at 3.0 Angstroms Resolution
54. 2atc: Crystal and Molecular Structures of Native and Ctp-liganded Aspartate Carbamoyltransferase from Escherichia Coli
55. 2be7: Crystal Structure of The Unliganded (t-state) Aspartate Transcarbamoylase of The Psychrophilic Bacterium Moritella Profunda
56. 2be9: Crystal Structure of The Ctp-liganded (t-state) Aspartate Transcarbamoylase from The Extremely Thermophilic Archaeon Sulfolobus Acidocaldarius
57. 2rgw: Catalytic Subunit of M. Jannaschii Aspartate Transcarbamoylase
58. 2qgf: Structure of Regulatory Chain Mutant H20A of Asparate Transcarbamoylase from E. Coli
59. 2qg9: Structure of a Regulatory Subunit Mutant D19A of Atcase from E. Coli
60. 2fzc: The Structure of Wild-type E. Coli Aspartate Transcarbamoylase in Complex with Novel T State Inhibitors at 2.10 Resolution
61. 2fzg: The Structure of Wild-type E. Coli Aspartate Transcarbamoylase in Complex with Novel T State Inhibitors at 2.25 Resolution
62. 2fzk: The Structure of Wild-type E. Coli Aspartate Transcarbamoylase in Complex with Novel T State Inhibitors at 2.50 Resolution
63. 2h3e: Structure of Wild-type E. Coli Aspartate Transcarbamoylase in The Presence of N-phosphonacetyl-l-isoasparagine at 2.3a Resolution
64. 5ynz: Crystal Structure of The Dihydroorotase Domain (K1556A) of Human Cad
65. 2hse: Structure of D236A E. Coli Aspartate Transcarbamoylase in The Presence of Phosphonoacetamide and L-aspartate at 2.60 a Resolution
66. 2ipo: E. Coli Aspartate Transcarbamoylase Complexed with N- Phosphonacetyl-l-asparagine
67. 6pnz: The Structure of The Aspartate Transcarbamoylase Trimer from Staphylococcus Aureus Complexed with Pala at 2.27 Resolution.
68. 6jks: Crystal Structure of Aspartate Transcarbamoylase from Trypanosoma Cruzi in Complex with Carbamoyl Phosphate (cp) and Aspartate (asp)
69. 6kjb: Wild-type Apo-form E. Coli Atcase Holoenzyme with an Unusual Open Conformation of R167
70. 3npm: Crystal Structure of The C47A/A241C Disulfide-linked C6 Aspartate Transcarbamoylase Enzyme
71. 6kj7: E. Coli Atcase Catalytic Subunit Mutant - G166P
72. 3r7d: Crystal Structure of Unliganded Aspartate Transcarbamoylase from Bacillus Subtilis
73. 3r7f: Crystal Structure of Cp-bound Aspartate Transcarbamoylase from Bacillus Subtilis
74. 3r7l: Crystal Structure of Pala-bound Aspartate Transcarbamoylase from Bacillus Subtilis
75. 6jl5: Crystal Structure of Aspartate Transcarbamoylase from Trypanosoma Cruzi in Complex with Aspartate (asp) and Phosphate (pi).
76. 4e2f: Crystal Structure of E. Coli Aspartate Transcarbamoylase K164E/E239K Mutant in an Intermediate State
77. 4ekn: Structure of The Catalytic Chain of Methanococcus Jannaschii Aspartate Transcarbamoylase in a Hexagonal Crystal Form
78. 6kja: E. Coli Atcase Holoenzyme Mutant - G128/130a (catalytic Chain)
79. 4f04: A Second Allosteric Site in E. Coli Aspartate Transcarbamoylase: R- State Atcase with Utp Bound
80. 4fyv: Aspartate Transcarbamoylase Complexed with Dctp
81. 4fyw: E. Coli Aspartate Transcarbamoylase Complexed with Ctp
82. 4fyx: E. Coli Aspartate Transcarbamoylase Complexed with Dctp, Utp, and Mg2+
83. 4fyy: E. Coli Aspartate Transcarbamoylase Complexed with Ctp, Utp, and Mg2+
84. 6hl7: Crystal Structure of Truncated Aspartate Transcarbamoylase from Plasmodium Falciparum with Mutated Active Site (R109A/K138A) and N- Carbamoyl-l-phosphate Bound
85. 6hg3: Hybrid Dihydroorotase Domain of Human Cad with E. Coli Flexible Loop, Bound to Dihydroorotate
86. 6hg2: Hybrid Dihydroorotase Domain of Human Cad with E. Coli Flexible Loop, Bound to Fluoroorotate
87. 6hg1: Hybrid Dihydroorotase Domain of Human Cad with E. Coli Flexible Loop in Apo State
88. 6hfu: Human Dihydroorotase Mutant F1563Y Co-crystallized with Carbamoyl Aspartate at Ph 7.5
89. 6hfs: Human Dihydroorotase Mutant F1563Y Co-crystallized with Carbamoyl Aspartate at Ph 6.5
90. 6hfr: Human Dihydroorotase Mutant F1563Y Co-crystallized with Carbamoyl Aspartate at Ph 7.0
91. 6hfq: Human Dihydroorotase Mutant F1563T Co-crystallized with Carbamoyl Aspartate at Ph 7.5
92. 6hfp: Human Dihydroorotase Mutant F1563T Co-crystallized with Carbamoyl Aspartate at Ph 7.0
93. 6hfn: Human Dihydroorotase Mutant F1563L Co-crystallized with Carbamoyl Aspartate at Ph 7.5
94. 6hfl: Human Dihydroorotase Mutant F1563L Co-crystallized with Carbamoyl Aspartate at Ph 7.0
95. 6hfk: Human Dihydroorotase Mutant F1563L Co-crystallized with Carbamoyl Aspartate at Ph 6.5
96. 6hfj: Human Dihydroorotase Mutant F1563A Co-crystallized with Carbamoyl Aspartate at Ph 7.5
97. 6hfi: Human Dihydroorotase Mutant F1563A Apo Structure
98. 6hfh: Human Dihydroorotase Mutant F1563A Co-crystallized with Carbamoyl Aspartate at Ph 7.0
99. 6hff: Human Dihydroorotase Mutant F1563Y Apo Structure
100. 6hfe: Human Dihydroorotase Mutant F1563T Apo Structure
101. 6hfd: Human Dihydroorotase Mutant F1563L Apo Structure
102. 4iv5: X-ray Crystal Structure of a Putative Aspartate Carbamoyltransferase from Trypanosoma Cruzi
103. 6fba: Crystal Structure of Truncated Aspartate Transcarbamoylase from Plasmodium Falciparum with Bound Inhibitor 2,3-naphthalenediol
104. 4bjh: Crystal Structure of The Aquifex Reactor Complex Formed by Dihydroorotase (H180A, H232A) with Dihydroorotate and Aspartate Transcarbamoylase with N-(phosphonacetyl)-l- Aspartate (pala)
105. 4kgv: The R State Structure of E. Coli Atcase with Atp Bound
106. 4kgx: The R State Structure of E. Coli Atcase with Ctp Bound
107. 4kgz: The R State Structure of E. Coli Atcase with Utp and Magnesium Bound
108. 4kh0: The R State Structure of E. Coli Atcase with Atp and Magnesium Bound
109. 4kh1: The R State Structure of E. Coli Atcase with Ctp,utp, and Magnesium Bound
110. 6jl6: Crystal Structure of Aspartate Transcarbamoylase from Trypanosoma Cruzi in Complex with Phosphate (pi).
111. 5vmq: Structure of The R105A Mutant Catalytic Trimer of Escherichia Coli Aspartate Transcarbamoylase at 2.0-a Resolution
112. 5ilq: Crystal Structure of Truncated Unliganded Aspartate Transcarbamoylase from Plasmodium Falciparum
113. 5iln: Crystal Structure of Aspartate Transcarbamoylase from Plasmodium Falciparum (pfatc) with Bound Citrate
114. 5g1p: Aspartate Transcarbamoylase Domain of Human Cad Bound to Carbamoyl Phosphate
115. 5g1o: Aspartate Transcarbamoylase Domain of Human Cad in Apo Form
116. 5g1n: Aspartate Transcarbamoylase Domain of Human Cad Bound to Pala
117. 6jkr: Crystal Structure of Aspartate Transcarbamoylase from Trypanosoma Cruzi in Complex with Carbamoyl Phosphate (cp)