EC 2.6.1.1 - L- aspartate:2- oxoglutarate aminotransferase (aspartate transaminase)

3D structures of EC 2.6.1.1 - aspartate transaminase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1aam: The Structural Basis for The Altered Substrate Specificity of The R292D Active Site Mutant of Aspartate Aminotransferase from E. Coli
2. 1aat: Oxoglutarate-induced Conformational Changes in Cytosolic Aspartate Aminotransferase
3. 1aaw: The Structural Basis for The Altered Substrate Specificity of The R292D Active Site Mutant of Aspartate Aminotransferase from E. Coli
4. 1ahe: Aspartate Aminotransferase Hexamutant
5. 1ahf: Aspartate Aminotransferase Hexamutant
6. 1ahg: Aspartate Aminotransferase Hexamutant
7. 1ahx: Aspartate Aminotransferase Hexamutant
8. 1ahy: Aspartate Aminotransferase Hexamutant
9. 1aia: Structural Basis for The Catalytic Activity of Aspartate Aminotransferase K258H Lacking The Pyridoxal-5'-phosphate Binding Lysine Residue
10. 1aib: Structural Basis for The Catalytic Activity of Aspartate Aminotransferase K258H Lacking The Pyridoxal-5'-phsophate Binding Lysine Residue
11. 1aic: Structural Basis for The Catalytic Activity of Aspartate Aminotransferase K258H Lacking The Pyridoxal-5'-phsophate Binding Lysine Residue
12. 1ajr: Refinement and Comparison of The Crystal Structures of Pig Cytosolic Aspartate Aminotransferase and Its Complex with 2-methylaspartate
13. 1ajs: Refinement and Comparison of The Crystal Structures of Pig Cytosolic Aspartate Aminotransferase and Its Complex with 2-methylaspartate
14. 1aka: Structural Basis for The Catalytic Activity of Aspartate Aminotransferase K258H Lacking Its Pyridoxal-5'-phosphate- Binding Lysine Residue
15. 1akb: Structural Basis for The Catalytic Activity of Aspartate Aminotransferase K258H Lacking Its Pyridoxal-5'-phosphate- Binding Lysine Residue
16. 1akc: Structural Basis for The Catalytic Activity of Aspartate Aminotransferase K258H Lacking Its Pyridoxal-5'-phosphate- Binding Lysine Residue
17. 1ama: Domain Closure in Mitochondrial Aspartate Aminotransferase
18. 1amq: X-ray Crystallographic Study of Pyridoxamine 5'-phosphate- Type Aspartate Aminotransferases from Escherichia Coli in Three Forms
19. 1amr: X-ray Crystallographic Study of Pyridoxamine 5'-phosphate- Type Aspartate Aminotransferases from Escherichia Coli in Three Forms
20. 1ams: X-ray Crystallographic Study of Pyridoxamine 5'-phosphate- Type Aspartate Aminotransferases from Escherichia Coli in Three Forms
21. 1arg: Aspartate Aminotransferase, Phospho-5'-pyridoxyl Aspartate Complex
22. 1arh: Aspartate Aminotransferase, Y225R/R386A Mutant
23. 1ari: Aspartate Aminotransferase, W140H Mutant, Maleate Complex
24. 1ars: X-ray Crystallographic Study of Pyridoxal 5'-phosphate-type Aspartate Aminotransferases from Escherichia Coli in Open and Closed Form
25. 1art: X-ray Crystallographic Study of Pyridoxal 5'-phosphate-type Aspartate Aminotransferases from Escherichia Coli in Open and Closed Form
26. 1asa: The Structural Basis for The Reduced Activity of The Y226F(Y225F) Active Site Mutant of E. Coli Aspartate Aminotransferase
27. 1asb: The Structural Basis for The Reduced Activity of The D223A(D222A) Active Site Mutant of E. Coli Aspartate Aminotransferase
28. 1asc: The Structural Basis for The Reduced Activity of The D223A(D222A) Active Site Mutant of E. Coli Aspartate Aminotransferase
29. 1asd: The Structure of Wild Type E. Coli Aspartate Aminotransferase Reconstituted with N-meplp
30. 1ase: The Structure of Wild Type E. Coli Aspartate Aminotransferase Reconstituted with Plp-n-oxide
31. 1asf: The Structural Basis for The Reduced Activity of The Y226F(Y225F) Active Site Mutant of E. Coli Aspartate Aminotransferase
32. 1asg: The Structural Basis for The Reduced Activity of The Y226F(Y225F) Active Site Mutant of E. Coli Aspartate Aminotransferase
33. 1asl: Crystal Structures of Escherichia Coli Aspartate Aminotransferase in Two Conformations: Comparison of an Unliganded Open and Two Liganded Closed Forms
34. 1asm: Crystal Structures of Escherichia Coli Aspartate Aminotransferase in Two Conformations: Comparison of an Unliganded Open and Two Liganded Closed Forms
35. 1asn: Crystal Structures of Escherichia Coli Aspartate Aminotransferase in Two Conformations: Comparison of an Unliganded Open and Two Liganded Closed Forms
36. 1b4x: Aspartate Aminotransferase from E. Coli, C191S Mutation, with Bound Maleate
37. 1b5o: Thermus Thermophilus Aspartate Aminotransferase Single Mutant 1
38. 1b5p: Thermus Thermophilus Aspartate Aminotransferase Double Mutant 1
39. 1bjw: Aspartate Aminotransferase from Thermus Thermophilus
40. 1bkg: Aspartate Aminotransferase from Thermus Thermophilus with Maleate
41. 1bqa: Aspartate Aminotransferase P195A Mutant
42. 1bqd: Aspartate Aminotransferase P138A/P195A Double Mutant
43. 1c9c: Aspartate Aminotransferase Complexed with C3-pyridoxal-5'- Phosphate
44. 1cq6: Aspartate Aminotransferase Complex with C4-pyridoxal-5p- Phosphate
45. 1cq7: Aspartate Aminotransferase (e.c. 2.6.1.1) Complexed with C5- Pyridoxal-5p-phosphate
46. 1cq8: Aspartate Aminotransferase (e.c. 2.6.1.1) Complexed with C6- Pyridoxal-5p-phosphate
47. 1czc: Aspartate Aminotransferase Mutant Atb17/139s/142n with Glutaric Acid
48. 1cze: Aspartate Aminotransferase Mutant Atb17/139s/142n with Succinic Acid
49. 1g4v: Aspartate Aminotransferase Active Site Mutant N194A/Y225F
50. 1g4x: Aspartate Aminotransferase Active Site Mutant N194A/R292L
51. 1g7w: Aspartate Aminotransferase Active Site Mutant N194A/R386L
52. 1g7x: Aspartate Aminotransferase Active Site Mutant N194A/R292L/R386L
53. 1gc3: Thermus Thermophilus Aspartate Aminotransferase Tetra Mutant 2 Complexed with Tryptophan
54. 1gc4: Thermus Thermophilus Aspartate Aminotransferase Tetra Mutant 2 Complexed with Aspartate
55. 1gck: Thermus Thermophilus Aspartate Aminotransferase Double Mutant 1 Complexed with Aspartate
56. 1ivr: Structure of Aspartate Aminotransferase
57. 1ix6: Aspartate Aminotransferase Active Site Mutant V39F
58. 1ix7: Aspartate Aminotransferase Active Site Mutant V39F Maleate Complex
59. 1ix8: Aspartate Aminotransferase Active Site Mutant V39F/N194A
60. 1j32: Aspartate Aminotransferase from Phormidium Lapideum
61. 9aat: X-ray Structure Refinement and Comparison of Three Forms of Mitochondrial Aspartate Aminotransferase
62. 8aat: X-ray Structure Refinement and Comparison of Three Forms of Mitochondrial Aspartate Aminotransferase
63. 7aat: X-ray Structure Refinement and Comparison of Three Forms of Mitochondrial Aspartate Aminotransferase
64. 5eaa: Aspartate Aminotransferase from E. Coli, C191S Mutation
65. 5bj4: Thermus Thermophilus Aspartate Aminotransferase Tetra Mutant 2
66. 5bj3: Thermus Thermophilus Aspartate Aminotransferase Tetra Mutant 1
67. 3pdb: Crystal Structure of Mouse Mitochondrial Aspartate Aminotransferase in Complex with Oxaloacetic Acid
68. 3pd6: Crystal Structure of Mouse Mitochondrial Aspartate Aminotransferase, a Newly Identified Kynurenine Aminotransferase-iv
69. 3paa: Mechanism of Inactivation of E. Coli Aspartate Aminotransferase by (s)-4-amino-4,5-dihydro-2-furancarboxylic Acid (s-adfa) Ph 8.0
70. 3pa9: Mechanism of Inactivation of E. Coli Aspartate Aminotransferase by (s)-4-amino-4,5-dihydro-2-furancarboxylic Acid (s-adfa) Ph 7.5
71. 1map: Crystal Structures of True Enzymatic Reaction Intermediates: Aspartate and Glutamate Ketimines in Aspartate Aminotransferase
72. 1maq: Crystal Structures of True Enzymatic Reaction Intermediates: Aspartate and Glutamate Ketimines in Aspartate Aminotransferase
73. 3meb: Structure of Cytoplasmic Aspartate Aminotransferase from Giardia Lamblia
74. 1o4s: Crystal Structure of Aspartate Aminotransferase (tm1255) from Thermotoga Maritima at 1.90 a Resolution
75. 3k7y: Aspartate Aminotransferase of Plasmodium Falciparum
76. 1oxo: Aspartate Aminotransferase, H-asp Complex, Open Conformation
77. 1oxp: Aspartate Aminotransferase, H-asp Complex, Closed Conformation
78. 3ii0: Crystal Structure of Human Glutamate Oxaloacetate Transaminase 1 (got1)
79. 1qir: Aspartate Aminotransferase from Escherichia Coli, C191Y Mutation, with Bound Maleate
80. 1qis: Aspartate Aminotransferase from Escherichia Coli, C191F Mutation, with Bound Maleate
81. 1qit: Aspartate Aminotransferase from Escherichia Coli, C191W Mutation, with Bound Maleate
82. 3hlm: Crystal Structure of Mouse Mitochondrial Aspartate Aminotransferase/kynurenine Aminotransferase IV
83. 1spa: Role of Asp222 in The Catalytic Mechanism of Escherichia Coli Aspartate Aminotransferase: The Amino Acid Residue Which Enhances The Function of The Enzyme-bound Coenzyme Pyridoxal 5'-phosphate
84. 3f6t: Crystal Structure of Aspartate Aminotransferase (e.c. 2.6.1.1) (yp_194538.1) from Lactobacillus Acidophilus Ncfm at 2.15 a Resolution
85. 1tar: Crystalline Mitochondrial Aspartate Aminotransferase Exists in Only Two Conformations
86. 1tas: Crystalline Mitochondrial Aspartate Aminotransferase Exists in Only Two Conformations
87. 1tat: Crystalline Mitochondrial Aspartate Aminotransferase Exists in Only Two Conformations
88. 1toe: Unliganded Structure of Hexamutant + A293D Mutant of E. Coli Aspartate Aminotransferase
89. 1tog: Hydrocinnamic Acid-bound Structure of Srhept + A293D Mutant of E. Coli Aspartate Aminotransferase
90. 1toi: Hydrocinnamic Acid-bound Structure of Hexamutant + A293D Mutant of E. Coli Aspartate Aminotransferase
91. 1toj: Hydrocinnamic Acid-bound Structure of Srhept Mutant of E. Coli Aspartate Aminotransferase
92. 1tok: Maleic Acid-bound Structure of Srhept Mutant of E. Coli Aspartate Aminotransferase
93. 3aat: Activity and Structure of The Active-site Mutants R386Y and R386F of Escherichia Coli Aspartate Aminotransferase
94. 1x28: Crystal Structure of E.coli Aspat Complexed with N- Phosphopyridoxyl-l-glutamic Acid
95. 1x29: Crystal Structure of E.coli Aspat Complexed with N- Phosphopyridoxyl-2-methyl-l-glutamic Acid
96. 1x2a: Crystal Structure of E.coli Aspat Complexed with N- Phosphopyridoxyl-d-glutamic Acid
97. 2z61: Crystal Structure of Mj0684 from Methanococcus Jannaschii Reveals Its Similarity in The Active Site to Kynurenine Aminotransferases
98. 1yaa: Aspartate Aminotransferase from Saccharomyces Cerevisiae Cytoplasm
99. 1yoo: Aspartate Aminotransferase Mutant Atb17 with Isovaleric Acid
100. 6lig: Crystal Structure of Human Glutamate Oxaloacetate Transaminase 1 (got1) in Complex with Ah
101. 2aat: 2.8-angstroms-resolution Crystal Structure of an Active- Site Mutant of Aspartate Aminotransferase from Escherichia Coli
102. 2qbt: Structural Studies Reveal The Inactivation of E. Coli L- Aspartate Aminotransferase by (s)-4,5-amino-dihydro-2- Thiophenecarboxylic Acid (sadta) via Two Mechanisms (at Ph 8.0)
103. 2qb3: Structural Studies Reveal The Inactivation of E. Coli L- Aspartate Aminotransferase by (s)-4,5-dihydro-2- Thiophenecarboxylic Acid (sadta) via Two Mechanisms (at Ph 7.5)
104. 2qb2: Structural Studies Reveal The Inactivation of E. Coli L- Aspartate Aminotransferase by (s)-4,5-dihydro- 2thiophenecarboylic Acid (sadta) via Two Mechanisms (at Ph 7.0).
105. 2qa3: Structural Studies Reveal The Inactivation of E. Coli L- Aspartate Aminotransferase by (s)-4,5-amino-dihydro-2- Thiophenecarboxylic Acid (sadta) via Two Mechanisms (at Ph6.5)
106. 2q7w: Structural Studies Reveals The Inactivation of E. Coli L- Aspartate Aminotransferase (s)-4,5-amino-dihydro-2- Thiophenecarboxylic Acid (sadta) via Two Mechanisms at Ph 6.0
107. 2cst: Crystal Structure of The Closed Form of Chicken Cytosolic Aspartate Aminotransferase at 1.9 Angstroms Resolution
108. 2d5y: Aspartate Aminotransferase Mutant Mc with Isovaleric Acid
109. 2d61: Aspartate Aminotransferase Mutant Ma with Maleic Acid
110. 2d63: Aspartate Aminotransferase Mutant Ma with Isovaleric Acid
111. 2d64: Aspartate Aminotransferase Mutant Mabc with Isovaleric Acid
112. 2d65: Aspartate Aminotransferase Mutant Mabc
113. 2d66: Aspartate Aminotransferase Mutant Mab
114. 2d7y: Aspartate Aminotransferase Mutant Ma
115. 2d7z: Aspartate Aminotransferase Mutant Mab Complexed with Maleic Acid
116. 2o1b: Structure of Aminotransferase from Staphylococcus Aureus
117. 3ppl: Crystal Structure of an Aspartate Transaminase (ncgl0237, Cgl0240) from Corynebacterium Glutamicum Atcc 13032 Kitasato at 1.25 a Resolution
118. 3qn6: Crystal Structures of Escherichia Coli Aspartate Aminotransferase Reconstituted with 1-deaza-pyridoxal 5'-phosphate: Internal Aldimine and Stable L-aspartate External Aldimine
119. 3qpg: Crystal Structures of Escherichia Coli Aspartate Aminotransferase Reconstituted with 1-deaza-pyridoxal 5'-phosphate: Internal Aldimine and Stable L-aspartate External Aldimine
120. 3zzj: Structure of an Engineered Aspartate Aminotransferase
121. 3zzk: Structure of an Engineered Aspartate Aminotransferase
122. 4a00: Structure of an Engineered Aspartate Aminotransferase
123. 4eu1: Structure of a Mitochondrial Aspartate Aminotransferase from Trypanosoma Brucei
124. 6jpk: Crystal Structure of S. Pombe Aspartate Aminotransferase
125. 4h51: Crystal Structure of a Putative Aspartate Aminotransferase from Leishmania Major Friedlin
126. 4dbc: Substrate Activation in Aspartate Aminotransferase
127. 4f5f: Structure of Aspartate Aminotransferase Conversion to Tyrosine Aminotransferase: Chimera P1.
128. 4f5g: Rational Design and Directed Evolution of E. Coli Apartate Aminotransferase to Tyrosine Aminotransferase: Mutant P2.
129. 4f5h: Intercoversion of Substrate Specificity: E. Coli Aspatate Aminotransferase to Tyrosine Aminotransferase: Chimera P3.
130. 4f5i: Substrate Specificity Conversion of E. Coli Pyridoxal-5'-phosphate Dependent Aspartate Aminotransferase to Tyrosine Aminotransferase: Chimera P4.
131. 4f5j: Rational Design and Directed Evolution for Conversion of Substrate Specificity from E.coli Aspartate Aminotransferase to Tyrosine Aminotransferase: Mutant P5.
132. 4f5k: Substrate Specificity Conversion of Aspartate Aminotransferase to Tyrosine Aminotransferase by The Janus Algorithm: Chimera P6.
133. 4f5m: Wild-type E. Coli Aspartate Aminotransferase: a Template for The Interconversion of Substrate Specificity and Activity to Tyrosine Aminotransferase by The Janus Algorithm.
134. 4f5l: A Theoretical Optimized Mutant for The Conversion of Substrate Specificity and Activity of Aspartate Aminotransferase to Tyrosine Aminotransferase: Chimera P7.
135. 6f77: Crystal Structure of The Prephenate Aminotransferase from Rhizobium Meliloti
136. 6f5v: Crystal Structure of The Prephenate Aminotransferase from Arabidopsis Thaliana
137. 6f35: Crystal Structure of The Aspartate Aminotranferase from Rhizobium Meliloti
138. 6ezl: Crystal Structure of Aspartate Aminotransferase from Trypanosoma Cruzi at 2.07 Angstrom Resolution
139. 6dnd: Crystal Structure of Wild-type (wt) Human Glutamate Oxaloacetate Transaminase 1 (got1)
140. 6dnb: Crystal Structure of T110A:S256A Mutant Human Glutamate Oxaloacetate Transaminase 1 (got1)
141. 6dna: Crystal Structure of T110A Mutant Human Glutamate Oxaloacetate Transaminase 1 (got1)
142. 5wml: Arabidopsis Thaliana Prephenate Aminotransferase Mutant- K306A
143. 5wmk: Arabidopsis Thaliana Prephenate Aminotransferase Double Mutant- T84V K169V
144. 5wmi: Arabidopsis Thaliana Prephenate Aminotransferase Mutant- T84V
145. 5wmh: Arabidopsis Thaliana Prephenate Aminotransferase
146. 5vwr: E.coli Aspartate Aminotransferase-(1r,3s,4s)-3-amino-4- Fluorocyclopentane-1-carboxylic Acid (fcp)-alpha-ketoglutarate
147. 5vwq: E.coli Aspartate Aminotransferase-(1r,3s,4s)-3-amino-4- Fluorocyclopentane-1-carboxylic Acid (fcp)
148. 5vk7: Aspartate Aminotransferase Ph 4.0
149. 5vjz: Joint X-ray/neutron Structure of Aspartate Aminotransferase with Alpha-methyl-aspartate at Ph 7.5
150. 4w5k: Structure of a Mitochondrial Aspartate Aminotransferase from Trypanosoma Brucei, K237A Mutant
151. 5tot: Crystal Structure of Aat H143L:H189L Double Mutant
152. 5tor: Crystal Structure of Aat D222T Mutant
153. 5toq: High Resolution Crystal Structure of Aat
154. 5ton: Crystal Structure of Aat H143L Mutant
155. 5t4l: Plp and Gaba Trigger Gabr-mediated Transcription Regulation in Bacillus Subsidies via External Aldimine Formation
156. 5iwq: Crystal Structure of Aspartate Aminotransferase (aspat) from Corynebacterium Glutamicum Atcc 13032
157. 5hxx: Crystal Structure of Aspat from Corynebacterium Glutamicum
158. 5ax8: Recombinant Expression, Purification and Preliminary Crystallographic Studies of The Mature Form of Human Mitochondrial Aspartate Aminotransferase
159. 3wzf: Crystal Structure of Human Cytoplasmic Aspartate Aminotransferase
160. 7kz3: Crystal Structure of Kaba from Bacillus Cereus Uw85 in Complex with The Internal Aldimine
161. 7kz5: Crystal Structure of Kaba from Bacillus Cereus Uw85 in Complex with The Plp External Aldimine Adduct with Kanosamine-6-phosphate
162. 7kz6: Crystal Structure of Kaba from Bacillus Cereus Uw85 with Bound Cofactor Pmp
163. 7kzd: Crystal Structure of Kaba from Bacillus Cereus Uw85 in Complex with The Reduced Internal Aldimine and with Bound Glutarate