EC 2.1.1.43 - S- adenosyl- L- methionine:histone- L- lysine N ⁶ - methyltransferase (histone- lysine N- methyltransferase)

3D structures of EC 2.1.1.43 - histone-lysine N-methyltransferase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1h3i: Crystal Structure of The Histone Methyltransferase Set7/9
2. 3pdn: Crystal Structure of Smyd3 in Complex with Methyltransferase Inhibitor Sinefungin
3. 3mts: Chromo Domain of Human Histone-lysine N-methyltransferase SUV39H1
4. 1ml9: Structure of The Neurospora Set Domain Protein Dim-5, a Histone Lysine Methyltransferase
5. 3mqm: Crystal Structure of The Bromodomain of Human ASH1L
6. 3mo5: Human G9A-LIKE (glp, Also Known as Ehmt1) in Complex with Inhibitor E72
7. 3mo2: Human G9A-LIKE (glp, Also Known as Ehmt1) in Complex with Inhibitor E67
8. 3mo0: Human G9A-LIKE (glp, Also Known as Ehmt1) in Complex with Inhibitor E11
9. 1mt6: Structure of Histone H3 K4-specific Methyltransferase Set7/9 with Adohcy
10. 1muf: Structure of Histone H3 K4-specific Methyltransferase Set7/9
11. 3mek: Crystal Structure of Human Histone-lysine N- Methyltransferase Smyd3 in Complex with S-adenosyl-l- Methionine
12. 3m5a: Set7/9 Y245A in Complex with TAF10-K189ME3 Peptide and Adohcy
13. 3m59: Set7/9 Y245A in Complex with TAF10-K189ME2 Peptide and Adohcy
14. 3m58: Set7/9 Y245A in Complex with TAF10-K189ME1 Peptide and Adohcy
15. 3m57: Set7/9 Y245A in Complex with Taf10 Peptide and Adohcy
16. 3m56: Set7/9 Y305F in Complex with TAF10-K189ME2 Peptide and Adohcy
17. 3m55: Set7/9 Y305F in Complex with TAF10-K189ME1 Peptide and Adohcy
18. 3m54: Set7/9 Y305F in Complex with Taf10 Peptide and Adohcy
19. 3m53: Set7/9 in Complex with Taf10 Peptide and Adohcy
20. 3lqh: Crystal Structure of Mll1 Phd3-bromo in The Free Form
21. 1o9s: Crystal Structure of a Ternary Complex of The Human Histone Methyltransferase Set7/9
22. 3k9k: Transposase Domain of Metnase
23. 3k9j: Transposase Domain of Metnase
24. 3k5k: Discovery of a 2,4-diamino-7-aminoalkoxy-quinazoline as a Potent Inhibitor of Histone Lysine Methyltransferase, G9A
25. 1peg: Structural Basis for The Product Specificity of Histone Lysine Methyltransferases
26. 3hna: Crystal Structure of Catalytic Domain of Human Euchromatic Histone Methyltransferase 1 in Complex with Sah and Mono- Methylated H3K9 Peptide
27. 3fpd: G9A-LIKE Protein Lysine Methyltransferase Inhibition by Bix- 01294
28. 3f9z: Structural Insights into Lysine Multiple Methylation by Set Domain Methyltransferases, SET8-Y245F / H4-lys20 / Adohcy
29. 3f9y: Structural Insights into Lysine Multiple Methylation by Set Domain Methyltransferases, SET8-Y334F / H4-LYS20ME1 / Adohcy
30. 3f9x: Structural Insights into Lysine Multiple Methylation by Set Domain Methyltransferases, SET8-Y334F / H4-LYS20ME2 / Adohcy
31. 3f9w: Structural Insights into Lysine Multiple Methylation by Set Domain Methyltransferases, SET8-Y334F / H4-lys20 / Adohcy
32. 3f2k: Structure of The Transposase Domain of Human Histone-lysine N-methyltransferase Setmar
33. 1u2z: Crystal Structure of Histone K79 Methyltransferase DOT1P from Yeast
34. 3dlm: Crystal Structure of Tudor Domain of Human Histone-lysine N- Methyltransferase Setdb1
35. 3cbp: Set7/9-er-sinefungin Complex
36. 3cbo: Set7/9-er-adohcy Complex
37. 3cbm: Set7/9-er-adomet Complex
38. 3bo5: Crystal Structure of Methyltransferase Domain of Human Histone-lysine N-methyltransferase Setmar
39. 3b7b: Euhmt1 (glp) Ankyrin Repeat Domain (structure 1)
40. 2yuk: Solution Structure of The Hmg Box of Human Myeloid/lymphoid or Mixed-lineage Leukemia Protein 3 Homolog
41. 2ysm: Solution Structure of The First and Second Phd Domain from Myeloid/lymphoid or Mixed-lineage Leukemia Protein 3 Homolog
42. 1xqh: Crystal Structure of a Ternary Complex of The Methyltransferase Set9 (also Known as Set7/9) with a P53 Peptide and Sah
43. 2w5z: Ternary Complex of The Mixed Lineage Leukaemia (mll1) Set Domain with The Cofactor Product S-adenosylhomocysteine and Histone Peptide.
44. 2w5y: Binary Complex of The Mixed Lineage Leukaemia (mll1) Set Domain with The Cofactor Product S-adenosylhomocysteine.
45. 1zkk: Crystal Structure of Hset8 in Ternary Complex with H4 Peptide (16-24) and Adohcy
46. 2rfi: Crystal Structure of Catalytic Domain of Human Euchromatic Histone Methyltransferase 1 in Complex with Sah and Dimethylated H3K9 Peptide
47. 2bqz: Crystal Structure of a Ternary Complex of The Human Histone Methyltransferase Pr-set7 (also Known as Set8)
48. 2r3a: Methyltransferase Domain of Human Suppressor of Variegation 3-9 Homolog 2
49. 2qxv: Structural Basis of Ezh2 Recognition by Eed
50. 2o8j: Human Euchromatic Histone Methyltransferase 2
51. 6c24: Cryo-em Structure of Prc2 Bound to Cofactors Aebp2 and Jarid2 in The Extended Active State
52. 6c23: Cryo-em Structure of Prc2 Bound to Cofactors Aebp2 and Jarid2 in The Compact Active State
53. 6by9: Crystal Structure of Ehmt1
54. 6bx3: Structure of Histone H3K4 Methyltransferase
55. 6bpi: Crystal Structure of Setdb1 Tudor Domain with Aryl Triazole Fragment Peptide Conjugates
56. 6bp4: Structure of The S. Pombe Clr4 Catalytic Domain Bound to Sam
57. 6boz: Structure of Human Setd8 in Complex with Covalent Inhibitor Ms4138
58. 6box: Structure of The S. Pombe Clr4 Catalytic Domain Bound to Sah
59. 6bhi: Crystal Structure of Setdb1 with a Modified H3 Peptide
60. 6bhh: Crystal Structure of Setdb1 with a Modified H3 Peptide
61. 6bhg: Crystal Structure of Setdb1 with a Modified H3 Peptide
62. 6bhe: Crystal Structure of Setdb1 with a Modified H3 Peptide
63. 6bhd: Crystal Structure of Setdb1 with a Modified H3 Peptide
64. 6au3: Crystal Structure of Setdb1 Tudor Domain with Aryl Triazole Fragments
65. 6au2: Crystal Structure of Setdb1 Tudor Domain with Aryl Triazole Fragments
66. 6ago: Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex
67. 6a5n: Crystal Structure of Arabidopsis Thaliana Suvh6 in Complex with Methylated Dna
68. 6a5m: Crystal Structure of Arabidopsis Thaliana Suvh6 in Complex with Sam, Form 2
69. 6a5k: Crystal Structure of Arabidopsis Thaliana Suvh6 in Complex with Sam, Form 1
70. 2f69: Ternary Complex of Set7/9 Bound to Adohcy and a Taf10 Peptide
71. 5yvx: Crystal Structure of Sdg8 Cw Domain in Complex with H3K4ME1 Peptide
72. 5ylt: Crystal Structure of Set7/9 in Complex with a Cyproheptadine Derivative
73. 6ten: Crystal Structure of DOT1L in Complex with an Inhibitor (compound 11).
74. 6tel: Crystal Structure of DOT1L in Complex with an Inhibitor (compound 10).
75. 6te6: Crystal Structure of DOT1L in Complex with an Inhibitor (compound 3).
76. 2igq: Human Euchromatic Histone Methyltransferase 1
77. 2j8a: X-ray Structure of The N-terminus Rrm Domain of Set1
78. 6u9r: Mll1 Set N3861I/Q3867L Bound to Inhibitor 12 (tc-5140)
79. 6u9n: Mll1 Set N3861I/Q3867L Bound to Inhibitor 14 (tc-5139)
80. 6u9m: Mll1 Set N3861I/Q3867L Bound to Inhibitor 16 (tc-5109)
81. 6u9k: Mll1 Set N3861I/Q3867L Bound to Inhibitor 18 (tc-5153)
82. 6u4y: Crystal Structure of an Ezh2-eed Complex in an Oligomeric State
83. 6t69: Crystal Structure of Toxoplasma Gondii Morn1(v Shape)
84. 6sqk: Crystal Structure of Mouse Prmt6 with Modified H7-4 Peptide
85. 2kkf: Solution Structure of Mll Cxxc Domain in Complex with Palindromic Cpg Dna
86. 6kqq: Nsd1 Set Domain in Complex with Bt3 and Sam
87. 3p4f: Structural and Biochemical Insights into Mll1 Core Complex Assembly and Regulation.
88. 3ooi: Crystal Structure of Human Histone-lysine N-methyltransferase Nsd1 Set Domain in Complex with S-adenosyl-l-methionine
89. 3ope: Structural Basis of Auto-inhibitory Mechanism of Histone Methyltransferase
90. 3os5: Set7/9-dnmt1 K142ME1 Complex
91. 3oxf: Human Lysine Methyltransferase Smyd3 in Complex with Adohcy (form I)
92. 3oxg: Human Lysine Methyltransferase Smyd3 in Complex with Adohcy (form Iii)
93. 3oxl: Human Lysine Methyltransferase Smyd3 in Complex with Adohcy (form Ii)
94. 3q0b: Crystal Structure of Suvh5 Sra- Fully Methylated Cg Dna Complex in Space Group P42212
95. 3q0c: Crystal Structure of Suvh5 Sra-fully Methylated Cg Dna Complex in Space Group P6122
96. 3q0d: Crystal Structure of Suvh5 Sra- Hemi Methylated Cg Dna Complex
97. 3q0f: Crystal Structure of Suvh5 Sra- Methylated Chh Dna Complex
98. 3qwp: Crystal Structure of Set and Mynd Domain Containing 3; Zinc Finger Mynd Domain-containing Protein 1
99. 3rjw: Crystal Structure of Histone Lysine Methyltransferase G9A with an Inhibitor
100. 2l7p: Ashh2 a Cw Domain
101. 3qow: DOT1L Structure in Complex with Sam
102. 3qox: DOT1L Structure in Complex with Sah
103. 3ru0: Cocrystal Structure of Human Smyd3 with Inhibitor Sinefungin Bound
104. 6o9o: Crystal Structure of Smyd3 with Potent and Selective Isoxazole Amide Inhibitor 1
105. 3rib: Human Lysine Methyltransferase Smyd2 in Complex with Adohcy
106. 3rq4: Crystal Structure of Suppressor of Variegation 4-20 Homolog 2
107. 3s8p: Crystal Structure of The Set Domain of Human Histone-lysine N- Methyltransferase SUV420H1 in Complex with S-adenosyl-l-methionine
108. 3smt: Crystal Structure of Human Set Domain-containing Protein3
109. 3sx0: Crystal Structure of DOT1L in Complex with a Brominated Sah Analog
110. 3s7b: Structural Basis of Substrate Methylation and Inhibition of Smyd2
111. 3s7d: Structural Basis of Substrate Methylation and Inhibition of Smyd2
112. 3s7f: Structural Basis of Substrate Methylation and Inhibition of Smyd2
113. 3s7j: Structural Basis of Substrate Methylation and Inhibition of Smyd2
114. 6pww: Cryo-em Structure of Mll1 in Complex with Rbbp5 and Wdr5 Bound to The Nucleosome
115. 6pwv: Cryo-em Structure of Mll1 in Complex with Rbbp5 and Wdr5 Bound to The Nucleosome
116. 3tg4: Structure of Smyd2 in Complex with Sam
117. 3tg5: Structure of Smyd2 in Complex with P53 and Sah
118. 6uh5: Structural Basis of Compass Ecm Recognition of The H2BUB Nucleosome
119. 6ugm: Structural Basis of Compass Ecm Recognition of an Unmodified Nucleosome
120. 6ue6: Pwwp1 Domain of Nsd2 in Complex with Mr837
121. 3sr4: Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor
122. 3sw9: Glp (G9A-LIKE Protein) Set Domain in Complex with DNMT3AK44ME0 Peptide
123. 3swc: Glp (G9A-LIKE Protein) Set Domain in Complex with DNMT3AK44ME2 Peptide
124. 6qxz: Solution Structure of The Ashh2 Cw Domain with The N-terminal Histone H3 Tail Mimicking Peptide Monomethylated on Lysine 4
125. 3uvk: Crystal Structure of Wdr5 in Complex with The Wdr5-interacting Motif of Mll2
126. 3uvl: Crystal Structure of Wdr5 in Complex with The Wdr5-interacting Motif of Mll3
127. 3uvm: Crystal Structure of Wdr5 in Complex with The Wdr5-interacting Motif of Mll4
128. 3uvn: Crystal Structure of Wdr5 in Complex with The Wdr5-interacting Motif of SET1A
129. 3uvo: Crystal Structure of Wdr5 in Complex with The Wdr5-interacting Motif of SET1B
130. 6px3: Set2 Bound to Nucleosome
131. 3u85: Crystal Structure of Human Menin in Complex with Mll1
132. 3u88: Crystal Structure of Human Menin in Complex with Mll1 and Ledgf
133. 6p0r: Methyltransferase Domain of Human Suppressor of Variegation 3-9 Homolog 2 (SUV39H2) in Complex with Ots186935 Inhibitor
134. 3uwp: Crystal Structure of DOT1L in Complex with 5-iodotubercidin
135. 6o96: DOT1L Bound to The H2BK120 Ubiquitinated Nucleosome
136. 6o7g: Solution Structure of Mll4 Phd6 Domain in Complex with Histone H4K16AC Peptide
137. 4e47: Set7/9 in Complex with Inhibitor (r)-(3-(3-cyanophenyl)-1-oxo-1- (pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6- Sulfonamide and S-adenosylmethionine
138. 6nzo: Set2 Bound to Nucleosome
139. 6nqa: Active State DOT1L Bound to The H2B-UBIQUITINATED Nucleosome, 1-to-1 Complex
140. 6nog: Poised-state DOT1L Bound to The H2B-UBIQUITINATED Nucleosome
141. 6nn6: Structure of DOT1L-H2BK120UB Nucleosome Complex
142. 6nm4: Crystal Structure of Sam-bound Prdm9 in Complex with Mrk-740 Inhibitor
143. 6nj9: Active State DOT1L Bound to The H2B-UBIQUITINATED Nucleosome, 2-to-1 Complex
144. 4eqz: Crystal Structure of Human DOT1L in Complex with Inhibitor Fed2
145. 4er0: Crystal Structure of Human DOT1L in Complex with Inhibitor Fed1
146. 4er3: Crystal Structure of Human DOT1L in Complex with Inhibitor Epz004777
147. 4er5: Crystal Structure of Human DOT1L in Complex with 2 Molecules of Epz004777
148. 4er6: Crystal Structure of Human DOT1L in Complex with Inhibitor Sgc0946
149. 4er7: Crystal Structure of Human DOT1L in Complex with Inhibitor Sgc0947
150. 4erq: X-ray Structure of Wdr5-mll2 Win Motif Peptide Binary Complex
151. 4ery: X-ray Structure of Wdr5-mll3 Win Motif Peptide Binary Complex
152. 4erz: X-ray Structure of Wdr5-mll4 Win Motif Peptide Binary Complex
153. 4es0: X-ray Structure of WDR5-SETD1B Win Motif Peptide Binary Complex
154. 4esg: X-ray Structure of Wdr5-mll1 Win Motif Peptide Binary Complex
155. 4ewr: X-ray Structure of WDR5-SETD1A Win Motif Peptide Binary Complex
156. 6n3g: Crystal Structure of Histone Lysine Methyltransferase Smyd2 in Complex with Polyethylene Glycol
157. 6mon: Crystal Structure of Human Smyd2 in Complex with Nle-peptide Inhibitor
158. 6mm1: Structure of The Cysteine-rich Region from Human Ehmt2
159. 6mlc: Phd6 Domain of Mll3 in Complex with Histone H4
160. 6mbp: Glp Methyltransferase with Inhibitor Eml741- P3121 Crystal Form
161. 6mbo: Glp Methyltransferase with Inhibitor Eml741-p212121 Crystal Form
162. 6mbl: Setd3, a Histidine Methyltransferase, in Complex with an Actin Peptide and Sah, Second P212121 Crystal Form
163. 6mbk: Setd3, a Histidine Methyltransferase, in Complex with an Actin Peptide and Sah, First P212121 Crystal Form
164. 6mbj: Setd3, a Histidine Methyltransferase, in Complex with an Actin Peptide and Sah, P21 Crystal Form
165. 6kiz: Cryo-em Structure of Human Mll1-ncp Complex, Binding Mode2
166. 6kix: Cryo-em Structure of Human Mll1-ncp Complex, Binding Mode1
167. 6kiw: Cryo-em Structure of Human Mll3-ubncp Complex (4.0 Angstrom)
168. 6kiv: Cryo-em Structure of Human Mll1-ubncp Complex (4.0 Angstrom)
169. 6kiu: Cryo-em Structure of Human Mll1-ubncp Complex (3.2 Angstrom)
170. 2lv9: Solution Nmr Structure of The Phd Domain of Human Mll5, Northeast Structural Genomics Consortium Target HR6512A
171. 6jn2: Crystal Structure of The Coiled-coil Domains of Human DOT1L in Complex with Af10
172. 6jma: Cryo-em Structure of DOT1L Bound to H2B Ubiquitinated Nucleosome
173. 6jm9: Cryo-em Structure of DOT1L Bound to Unmodified Nucleosome
174. 6j99: Cryo-em Structure of Human DOT1L in Complex with an H2B- Monoubiquitinated Nucleosome
175. 4fmu: Crystal Structure of Methyltransferase Domain of Human Set Domain- Containing Protein 2 Compound: Pr-snf
176. 4gq6: Human Menin
177. 6ine: Crystal Structure of Human ASH1L-MRG15 Complex
178. 6in3: Crystal Structure of DOT1L in Complex with 18-crown-6
179. 4ek9: Crystal Structure of DOT1L in Complex with Epz000004
180. 4ekg: Crystal Structure of DOT1L in Complex with Epz003696
181. 4eki: Crystal Structure of DOT1L in Complex with Epz004777
182. 6ijl: Crystal Structure of Smyd3 in Complex with Covalent Inhibitor 5
183. 4h12: The Crystal Structure of Methyltransferase Domain of Human Set Domain- Containing Protein 2 in Complex with S-adenosyl-l-homocysteine
184. 6icv: Structure of Setd3 Bound to Sah and Unmodified Actin
185. 6ict: Structure of Setd3 Bound to Sah and Methylated Actin
186. 4gnd: Crystal Structure of Nsd3 Tandem PHD5-C5HCH Domains
187. 4gne: Crystal Structure of Nsd3 Tandem PHD5-C5HCH Domains Complexed with H3 Peptide 1-7
188. 4gnf: Crystal Structure of Nsd3 Tandem PHD5-C5HCH Domains Complexed with H3 Peptide 1-15
189. 4gng: Crystal Structure of Nsd3 Tandem PHD5-C5HCH Domains Complexed with H3K9ME3 Peptide
190. 4i51: Methyltransferase Domain of Human Euchromatic Histone Methyltransferase 1, Mutant Y1211A
191. 4ij8: Crystal Structure of The Complex of Setd8 with Sam
192. 4ijd: Crystal Structure of Methyltransferase Domain of Human Pr Domain- Containing Protein 9
193. 3vuz: Crystal Structure of Histone Methyltransferase Set7/9 in Comlex with Aam-1
194. 3vv0: Crystal Structure of Histone Methyltransferase Set7/9 in Comlex with Daam-3
195. 4jds: Setd7 in Complex with Inhibitor Pf-5426 and S-adenosyl-methionine
196. 4jlg: Setd7 in Complex with Inhibitor (r)-pfi-2 and S-adenosyl-homocysteine
197. 2lxs: Allosteric Communication in The Kix Domain Proceeds through Dynamic Re-packing of The Hydrophobic Core
198. 2lxt: Allosteric Communication in The Kix Domain Proceeds through Dynamic Re-packing of The Hydrophobic Core
199. 6g3t: X-ray Structure of Nsd3-pwwp1
200. 6g3p: X-ray Structure of Seleno-methionine Labelled Nsd3-pwwp1
201. 6g2o: X-ray Structure of Nsd3-pwwp1 in Complex with Compound Bi-9321
202. 6g2f: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 16
203. 6g2e: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 13
204. 6g2c: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 9
205. 6g2b: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 8
206. 6g29: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 6
207. 6g27: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 5
208. 6g25: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 4
209. 6g24: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 3
210. 4au7: The Structure of The Suv4-20h2 Ternary Complex with Histone H4
211. 4l58: Crystal Structure of The Mll5 Phd Finger in Complex with H3K4ME3
212. 6emq: Solution Structure of The Ledgf/p75 Ibd - Mll1 (aa 111-160) Complex
213. 4hra: Crystal Structure of DOT1L in Complex with Epz-5676
214. 6jat: Crystal Structure of Setd3 Bound to Actin Peptide and Sfg
215. 2lxe: S4WYILD
216. 2mdc: Solution Structure of The Ww Domain of Hypb
217. 2mdi: Solution Structure of The PP2WW Mutant (KPP2WW) of Hypb
218. 2mdj: Solution Structure of Ww Domain with Polyproline Stretch (PP2WW) of Hypb
219. 6cko: Crystal Structure of an Af10 Fragment
220. 6chg: Crystal Structure of The Yeast Compass Catalytic Module
221. 6cen: Crystal Structure of WHSC1L1 in Complex with Inhibitor Pep21
222. 6cby: Crystal Structure of Human Set and Mynd Domain Containing Protein 2 with Mtf9975
223. 6cbx: Crystal Structure of Human Set and Mynd Domain Containing Protein 2 with Mtf1497
224. 4bup: A Novel Route to Product Specificity in The Suv4-20 Family of Histone H4K20 Methyltransferases
225. 6p6g: Co-crystal Structure of Human Smyd3 with Isoxazole Amides Inhibitors
226. 6p6k: Co-crystal Structure of Human Smyd3 with Isoxazole Amides Inhibitors
227. 6p7z: Co-crystal Structure of Human Smyd3 with Isoxazole Amides Inhibitors
228. 6paf: Co-crystal Structure of Human Smyd3 with Isoxazole Amides Inhibitors
229. 4c1q: Crystal Structure of The Prdm9 Set Domain in Complex with H3K4ME2 and Adohcy.
230. 4j7f: SET7/9Y335PAF in Complex with Taf10 Peptide and Adohcy
231. 4j7i: SET7/9Y335F in Complex with Taf10 Peptide and Adohcy
232. 4j83: Set7/9 in Complex with TAF10K189A Peptide and Adomet
233. 4j8o: Set7/9 in Complex with TAF10K189A Peptide and Adohcy
234. 4mi0: Human Enhancer of Zeste (drosophila) Homolog 2(ezh2)
235. 4mi5: Crystal Structure of The Ezh2 Set Domain
236. 4nj5: Crystal Structure of Suvh9
237. 4nvq: Human G9A in Complex with Inhibitor A-366
238. 4o30: Crystal Structure of Atxr5 in Complex with Histone H3.1 and Adohcy
239. 4o6f: Structural Basis of Estrogen Receptor Alpha Methylation Mediated by Histone Methyltransferase Smyd2
240. 5yjo: Crystal Structure of Smyd3 in Complex with Covalent Inhibitor 4
241. 4pzi: Zinc Finger Region of Mll2 in Complex with Cpg Dna
242. 4qen: Crystal Structure of Kryptonite in Complex with Mchh Dna and Sah
243. 4qeo: Crystal Structure of Kryptonite in Complex with Mchh Dna, H3(1-15) Peptide and Sah
244. 4qep: Crystal Structure of Kryptonite in Complex with Mchg Dna and Sah
245. 5ww0: Crystal Structure of Set7, a Novel Histone Methyltransferase in Schizossacharomyces Pombe
246. 5wuk: Crystal Structure of Eed [G255D] in Complex with Ezh2 Peptide and Eed226 Compound
247. 5wg6: Human Polycomb Repressive Complex 2 in Complex with Gsk126 Inhibitor
248. 5wcg: Set and Mynd Domain Containing Protein 2
249. 5wbv: Crystal Structure of The Set Domain of Human SUV420H1 in Complex with Inhibitor
250. 5w1y: Setd8 in Complex with a Covalent Inhibitor
251. 5vsf: Structure of Human Glp Set-domain (ehmt1) in Complex with Inhibitor 17
252. 5vse: Structure of Human G9A Set-domain (ehmt2) in Complex with Inhibitor 17: N~2~-cyclopentyl-6,7-dimethoxy-n~2~-methyl-n~4~-(1- Methylpiperidin-4-yl)quinazoline-2,4-diamine
253. 5vsd: Structure of Human Glp Set-domain (ehmt1) in Complex with Inhibitor 13
254. 5vsc: Structure of Human G9A Set-domain (ehmt2) in Complex with Inhibitor 13
255. 5vc8: Crystal Structure of The Whsc1 Pwwp1 Domain
256. 5vbc: Crystal Structure of Atxr5 in Complex with Histone H3.1
257. 5vah: Crystal Structure of Atxr5 Set Domain in Complex with Histone H3 Di- Methylated on R26
258. 5vac: Crystal Structure of Atxr5 Set Domain in Complex with K36ME3 Histone H3 Peptide
259. 5va6: Crystal Structure of Atxr5 in Complex with Histone H3.1 Mono- Methylated on R26
260. 5v9j: Crystal Structure of Catalytic Domain of Glp with Ms0105
261. 5v9i: Crystal Structure of Catalytic Domain of G9A with Ms0105
262. 5v3h: Crystal Structure of Smyd2 with Sam and Epz033294
263. 5v3g: Prdm9-allele-c Znf8-13
264. 5v37: Crystal Structure of Smyd3 with Sam and Epz028862
265. 5v2n: Crystal Structure of Apo Human Setd8
266. 5v22: Crystal Structure of Human Setd2 Set-domain in Complex with H3K36M Peptide and Sah
267. 5v21: Crystal Structure of Human Setd2 Set-domain in Complex with H3K36M Peptide and Sam
268. 2mtn: Solution Structure of Mll-ibd Complex
269. 5upd: Methyltransferase Domain of Human Wolf-hirschhorn Syndrome Candidate 1-like Protein 1 (WHSC1L1)
270. 4wvl: Structure-guided DOT1L Probe Optimization by Label-free Ligand Displacement
271. 5u62: Crystal Structure of Eed in Complex with H3K27ME3 Peptide and 6- (benzo[d][1,3]dioxol-4-ylmethyl)-5,6,7,8-tetrahydroimidazo[1,5- A]pyridin-3-amine
272. 5u5t: Crystal Structure of Eed in Complex with H3K27ME3 Peptide and 3- (benzo[d][1,3]dioxol-4-ylmethyl)piperidine-1-carboximidamide
273. 5tuz: Structure of Human Glp Set-domain (ehmt1) in Complex with Inhibitor Ms0124
274. 5tuy: Structure of Human G9A Set-domain (ehmt2) in Complex with Inhibitor Ms0124
275. 5ttg: Crystal Structure of Catalytic Domain of Glp with Ms012
276. 5ttf: Crystal Structure of Catalytic Domain of G9A with Ms012
277. 5th7: Complex of Setd8 with Ms453
278. 5tfp: Crystal Structure of The Setdb2 Amino Terminal Domain
279. 5teg: Crystal Structure of Hsetd8 in Complex with Histone H4K20 Norleucine Mutant Peptide and S-adenosylmethionine
280. 5t5g: Human Setd8 in Complex with Ms2177
281. 5t0m: A Histone H3K9M Mutation Traps Histone Methyltransferase Clr4 to Prevent Heterochromatin Spreading
282. 5t0k: Structure of G9A Set-domain with H3K9M Mutant Peptide and Sam
283. 5svh: Crystal Structure of The Kix Domain of Cbp in Complex with a Mll/c-myb Chimera
284. 5qt2: Pandda Analysis Group Deposition -- Partial Occupancy Interpretation of Pandda Event Map: Setdb1 in Complex with FMOPL000074A
285. 5qt1: Pandda Analysis Group Deposition -- Partial Occupancy Interpretation of Pandda Event Map: Setdb1 in Complex with FMOMB000017A
286. 5mw4: Crystal Structure of DOT1L in Complex with Inhibitor Cpd7 [n-(3-(((r)- 1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)(methyl)amino) Propyl)-2-(3-(2-chloro-3-(2-methylpyridin-3-yl)benzo[b]thiophen-5- Yl)ureido)acetamide]
287. 5mw3: Crystal Structure of DOT1L in Complex with Inhibitor Cpd1 [n6-(2,6- Dichlorophenyl)-n6-(pent-2-yn-1-yl)quinoline-4,6-diamine] and Inhibitor Cpd2 [(r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3- Amine]
288. 5mvs: Crystal Structure of DOT1L in Complex with Adenosine and Inhibitor Cpd1 [n6-(2,6-dichlorophenyl)-n6-(pent-2-yn-1-yl)quinoline-4,6- Diamine]
289. 5lt8: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
290. 5lt7: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
291. 5lt6: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
292. 5lsz: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
293. 5lsy: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
294. 5lsx: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
295. 5lsu: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
296. 5lss: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
297. 5ls6: Structure of Human Polycomb Repressive Complex 2 (prc2) with Inhibitor
298. 5kjn: Smyd2 in Complex with Az506
299. 5kjm: Smyd2 in Complex with Az931
300. 5kjl: Smyd2 in Complex with Az378
301. 5kjk: Smyd2 in Complex with Az370
302. 5kh6: Setdb1 in Complex with a Fragment Candidate
303. 5kco: Setdb1 in Complex with an Early Stage, Low Affinity Fragment Candidate Modelled at Reduced Occupancy
304. 5kch: Setdb1 in Complex with an Early Stage, Low Affinity Fragment Candidate Modelled at Reduced Occupancy into Weak Electron Density
305. 5juw: Complex of DOT1L with Ss148
306. 5jle: Crystal Structure of Setd2 Bound to Sah
307. 5jlb: Crystal Structure of Setd2 Bound to Histone H3.3 K36I Peptide
308. 5jjy: Crystal Structure of Setd2 Bound to Histone H3.3 K36M Peptide
309. 5jj0: Structure of G9A Set-domain with Histone H3K9M Peptide and Excess Sah
310. 5jiy: Structure of G9A Set-domain with Histone H3K9NORLEUCINE Mutant Peptide and Bound S-adenosylmethionine
311. 5jin: Structure of G9A Set-domain with Histone H3K9M Mutant Peptide and Bound S-adenosylmethionine
312. 5jhn: Structure of G9A Set-domain with Histone H3K9ALA Mutant Peptide and Bound S-adenosylmethionine
313. 5ij8: Structure of The Primary Oncogenic Mutant Y641N Hs/acprc2 in Complex with a Pyridone Inhibitor
314. 5ij7: Structure of Hs/acprc2 in Complex with a Pyridone Inhibitor
315. 5hyn: Structure of Human Polycomb Repressive Complex 2 (prc2) with Oncogenic Histone H3K27M Peptide
316. 5ht6: Crystal Structure of The Set Domain of The Human Mll5 Methyltransferase
317. 5hq8: Co-crystal Structure of Human Smyd3 with a Mekk2 Peptide at 2.13a
318. 5hq2: Structural Model of Set8 Histone H4 Lys20 Methyltransferase Bound to Nucleosome Core Particle
319. 5hi7: Co-crystal Structure of Human Smyd3 with an Aza-sah Compound
320. 5h6z: Crystal Structure of Set7, a Novel Histone Methyltransferase in Schizossacharomyces Pombe
321. 5h25: Eed in Complex with Prc2 Allosteric Inhibitor Compound 11
322. 5h24: Eed in Complex with Prc2 Allosteric Inhibitor Compound 8
323. 5h19: Eed in Complex with Prc2 Allosteric Inhibitor Eed162
324. 5h17: Eed in Complex with Prc2 Allosteric Inhibitor Eed210
325. 5h15: Eed in Complex with Prc2 Allosteric Inhibitor Eed709
326. 5h14: Eed in Complex with an Allosteric Prc2 Inhibitor Eed666
327. 5gsa: Eed in Complex with an Allosteric Prc2 Inhibitor
328. 5f6l: The Crystal Structure of Mll1 (N3861I/Q3867L) in Complex with Rbbp5 and ASH2L
329. 5f6k: Crystal Structure of The MLL3-ASH2L-RBBP5 Complex
330. 5f5e: The Crystal Structure of Mll1 Set Domain with N3816I/Q3867L Mutation
331. 5f59: The Crystal Structure of Mll3 Set Domain
332. 5ex3: Crystal Structure of Human Smyd3 in Complex with a Vegfr1 Peptide
333. 5ex0: Crystal Structure of Human Smyd3 in Complex with a MAP3K2 Peptide
334. 5ei9: Human Prdm9 Allele-a Znf Domain with Associated Recombination Hotspot Dna Sequence I
335. 5eh2: Human Prdm9 Allele-a Znf Domain with Associated Recombination Hotspot Dna Sequence III
336. 5egb: Human Prdm9 Allele-a Znf Domain with Associated Recombination Hotspot Dna Sequence II
337. 5eg2: Set7/9 N265A in Complex with Adohcy and Taf10 Peptide
338. 5dtr: Crystal Structure of DOT1L in Complex with Inhibitor Cpd5 [n-(2,6- Dichlorophenyl)-4-methoxy-n-methylquinolin-6-amine]
339. 5dtq: Crystal Structure of DOT1L in Complex with Inhibitor Cpd3 [(2,6- Dichlorophenyl)(quinolin-6-yl)methanone]
340. 5dtm: Crystal Structure of DOT1L in Complex with Inhibitor Cpd1 [4-(2,6- Dichlorobenzoyl)-n-methyl-1h-pyrrole-2-carboxamide]
341. 5dt2: Crystal Structure of DOT1L in Complex with Inhibitor Cpd11 [n4-methyl- N2-(2-methyl-1-(2-phenoxyphenyl)-1h-indol-6-yl)pyrimidine-2,4- Diamine]
342. 5dsx: Crystal Structure of DOT1L in Complex with Inhibitor Cpd10 [6'-chloro- 1,4-dimethyl-5'-(2-methyl-6-((4-(methylamino)pyrimidin-2-yl)amino)- 1h-indol-1-yl)-[3,3'-bipyridin]-2(1h)-one]
343. 5dry: Crystal Structure of DOT1L in Complex with Inhibitor Cpd3 [n-(1-(2- Chlorophenyl)-1h-indol-6-yl)-2-(2-(5-(2-chlorophenyl)-1h-tetrazol-1- Yl)acetyl)hydrazinecarboxamide]
344. 5drt: Crystal Structure of DOT1L in Complex with Inhibitor Cpd2 [2-(2-(5- ((2-chlorophenoxy)methyl)-1h-tetrazol-1-yl)acetyl)-n-(4- Chlorophenyl)hydrazinecarboxamide]
345. 5cpr: The Novel Suv4-20 Inhibitor A-196 Verifies a Role for Epigenetics in Genomic Integrity
346. 5ccm: Crystal Structure of Smyd3 with Sam and Epz030456
347. 5ccl: Crystal Structure of Smyd3 with Sam and Oxindole Compound
348. 6j9j: Crystal Structure of Sestd2 in Complex with H3.3S31PHK36M Peptide
349. 5ayf: Crystal Structure of Set7/9 in Complex with Cyproheptadine
350. 5arg: Smyd2 in Complex with Sgc Probe Bay-598
351. 5arf: Smyd2 in Complex with Small Molecule Inhibitor Compound-2
352. 4rxj: Crystal Structure of WHSC1L1-PWWP2
353. 4z4p: Structure of The Mll4 Set Domain
354. 4wuy: Crystal Structure of Protein Lysine Methyltransferase Smyd2 in Complex with Lly-507, a Cell-active, Potent and Selective Inhibitor
355. 4ypu: ASH1L Set Domain K2264L Mutant in Complex with S-adenosyl Methionine (sam)
356. 4ype: ASH1L Set Domain H2193F Mutant in Complex with S-adenosyl Methionine (sam)
357. 4ypa: ASH1L Set Domain Q2265A Mutant in Complex with S-adenosyl Methionine (sam)
358. 2mv7: Solution Nmr Structure of DOT1L in Complex with Af9 (DOT1L-AF9)
359. 4ynp: ASH1L Set Domain S2259M Mutant in Complex with S-adenosyl Methionine (sam)
360. 4ynm: ASH1L Wild-type Set Domain in Complex with S-adenosyl Methionine (sam)
361. 4ygi: Crystal Structure of Suvh5 Sra Bound to Fully Hydroxymethylated Cg Dna
362. 4ynd: The Discovery of A-893, a New Cell-active Benzoxazinone Inhibitor of Lysine Methyltransferase Smyd2
363. 2naa: NSD1-PHD_5-C5HCH Tandem Domain Structure
364. 2ncz: Solution Nmr Structures of Brd4 Et Domain in Complex with Nsd3_1 Peptide
365. 2nd1: Solution Nmr Structures of Brd4 Et Domain in Complex with Nsd3_3 Peptide