Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy   |   
enzyme (lysozyme)

 
Enzymes
  Enzyme classes:
  EC 1: Oxidoreductases
  EC 2: Transferases
    EC 2.1
      EC 2.1.1
        EC 2.1.1.1
        EC 2.1.1.2
        EC 2.1.1.3
        EC 2.1.1.4
        EC 2.1.1.5
        EC 2.1.1.6
        EC 2.1.1.7
        EC 2.1.1.8
        EC 2.1.1.9
        EC 2.1.1.10
        EC 2.1.1.11
        EC 2.1.1.12
        EC 2.1.1.13
        EC 2.1.1.14
        EC 2.1.1.15
        EC 2.1.1.16
        EC 2.1.1.17
        EC 2.1.1.18
        EC 2.1.1.19
        EC 2.1.1.20
        EC 2.1.1.21
        EC 2.1.1.22
        EC 2.1.1.23
        EC 2.1.1.24
        EC 2.1.1.25
        EC 2.1.1.26
        EC 2.1.1.27
        EC 2.1.1.28
        EC 2.1.1.29
        EC 2.1.1.30
        EC 2.1.1.31
        EC 2.1.1.32
        EC 2.1.1.33
        EC 2.1.1.34
        EC 2.1.1.35
        EC 2.1.1.36
        EC 2.1.1.37
        EC 2.1.1.38
        EC 2.1.1.39
        EC 2.1.1.40
        EC 2.1.1.41
        EC 2.1.1.42
        EC 2.1.1.43
        EC 2.1.1.44
        EC 2.1.1.45
        EC 2.1.1.46
        EC 2.1.1.47
        EC 2.1.1.48
        EC 2.1.1.49
        EC 2.1.1.50
        EC 2.1.1.51
        EC 2.1.1.52
        EC 2.1.1.53
        EC 2.1.1.54
        EC 2.1.1.55
        EC 2.1.1.56
        EC 2.1.1.57
        EC 2.1.1.58
        EC 2.1.1.59
        EC 2.1.1.60
        EC 2.1.1.61
        EC 2.1.1.62
        EC 2.1.1.63
        EC 2.1.1.64
        EC 2.1.1.65
        EC 2.1.1.66
        EC 2.1.1.67
        EC 2.1.1.68
        EC 2.1.1.69
        EC 2.1.1.70
        EC 2.1.1.71
        EC 2.1.1.72
        EC 2.1.1.73
        EC 2.1.1.74
        EC 2.1.1.75
        EC 2.1.1.76
        EC 2.1.1.77
        EC 2.1.1.78
        EC 2.1.1.79
        EC 2.1.1.80
        EC 2.1.1.81
        EC 2.1.1.82
        EC 2.1.1.83
        EC 2.1.1.84
        EC 2.1.1.85
        EC 2.1.1.86
        EC 2.1.1.87
        EC 2.1.1.88
        EC 2.1.1.89
        EC 2.1.1.90
        EC 2.1.1.91
        EC 2.1.1.92
        EC 2.1.1.93
        EC 2.1.1.94
        EC 2.1.1.95
        EC 2.1.1.96
        EC 2.1.1.97
        EC 2.1.1.98
        EC 2.1.1.99
        EC 2.1.1.100
        EC 2.1.1.101
        EC 2.1.1.102
        EC 2.1.1.103
        EC 2.1.1.104
        EC 2.1.1.105
        EC 2.1.1.106
        EC 2.1.1.107
        EC 2.1.1.108
        EC 2.1.1.109
        EC 2.1.1.110
        EC 2.1.1.111
        EC 2.1.1.112
        EC 2.1.1.113
        EC 2.1.1.114
        EC 2.1.1.115
        EC 2.1.1.116
        EC 2.1.1.117
        EC 2.1.1.118
        EC 2.1.1.119
        EC 2.1.1.120
        EC 2.1.1.121
        EC 2.1.1.122
        EC 2.1.1.123
        EC 2.1.1.124
        EC 2.1.1.125
        EC 2.1.1.126
        EC 2.1.1.127
        EC 2.1.1.128
        EC 2.1.1.129
        EC 2.1.1.130
        EC 2.1.1.131
        EC 2.1.1.132
        EC 2.1.1.133
        EC 2.1.1.134
        EC 2.1.1.135
        EC 2.1.1.136
        EC 2.1.1.137
        EC 2.1.1.138
        EC 2.1.1.139
        EC 2.1.1.140
        EC 2.1.1.141
        EC 2.1.1.142
        EC 2.1.1.143
        EC 2.1.1.144
        EC 2.1.1.145
        EC 2.1.1.146
        EC 2.1.1.147
        EC 2.1.1.148
        EC 2.1.1.149
        EC 2.1.1.150
        EC 2.1.1.151
        EC 2.1.1.152
        EC 2.1.1.153
        EC 2.1.1.154
        EC 2.1.1.155
        EC 2.1.1.156
        EC 2.1.1.157
        EC 2.1.1.158
        EC 2.1.1.159
        EC 2.1.1.160
        EC 2.1.1.161
        EC 2.1.1.162
      EC 2.1.2
      EC 2.1.3
      EC 2.1.4
    EC 2.2
    EC 2.3
    EC 2.4
    EC 2.5
    EC 2.6
    EC 2.7
    EC 2.8
    EC 2.9
  EC 3: Hydrolases
  EC 4: Lyases
  EC 5: Isomerases
  EC 6: Ligases
  General information:
  Catalytic mechanism
  Enzyme kinetics
  Inhibitors
  Enzymes in industry

EC 2.1.1.43 - S- adenosyl- L- methionine:histone- L- lysine N 6 - methyltransferase (histone- lysine N- methyltransferase)



3D structures of EC 2.1.1.43 - histone-lysine N-methyltransferase in Protein Data Bank

updated: 6 January 2022, 2:15

In total: 365 PDB structures of EC 2.1.1.43 - histone-lysine N-methyltransferase:
  1. 1h3i: Crystal Structure of The Histone Methyltransferase Set7/9
  2. 3pdn: Crystal Structure of Smyd3 in Complex with Methyltransferase Inhibitor Sinefungin
  3. 3mts: Chromo Domain of Human Histone-lysine N-methyltransferase SUV39H1
  4. 1ml9: Structure of The Neurospora Set Domain Protein Dim-5, a Histone Lysine Methyltransferase
  5. 3mqm: Crystal Structure of The Bromodomain of Human ASH1L
  6. 3mo5: Human G9A-LIKE (glp, Also Known as Ehmt1) in Complex with Inhibitor E72
  7. 3mo2: Human G9A-LIKE (glp, Also Known as Ehmt1) in Complex with Inhibitor E67
  8. 3mo0: Human G9A-LIKE (glp, Also Known as Ehmt1) in Complex with Inhibitor E11
  9. 1mt6: Structure of Histone H3 K4-specific Methyltransferase Set7/9 with Adohcy
  10. 1muf: Structure of Histone H3 K4-specific Methyltransferase Set7/9
  11. 3mek: Crystal Structure of Human Histone-lysine N- Methyltransferase Smyd3 in Complex with S-adenosyl-l- Methionine
  12. 3m5a: Set7/9 Y245A in Complex with TAF10-K189ME3 Peptide and Adohcy
  13. 3m59: Set7/9 Y245A in Complex with TAF10-K189ME2 Peptide and Adohcy
  14. 3m58: Set7/9 Y245A in Complex with TAF10-K189ME1 Peptide and Adohcy
  15. 3m57: Set7/9 Y245A in Complex with Taf10 Peptide and Adohcy
  16. 3m56: Set7/9 Y305F in Complex with TAF10-K189ME2 Peptide and Adohcy
  17. 3m55: Set7/9 Y305F in Complex with TAF10-K189ME1 Peptide and Adohcy
  18. 3m54: Set7/9 Y305F in Complex with Taf10 Peptide and Adohcy
  19. 3m53: Set7/9 in Complex with Taf10 Peptide and Adohcy
  20. 3lqh: Crystal Structure of Mll1 Phd3-bromo in The Free Form
  21. 1o9s: Crystal Structure of a Ternary Complex of The Human Histone Methyltransferase Set7/9
  22. 3k9k: Transposase Domain of Metnase
  23. 3k9j: Transposase Domain of Metnase
  24. 3k5k: Discovery of a 2,4-diamino-7-aminoalkoxy-quinazoline as a Potent Inhibitor of Histone Lysine Methyltransferase, G9A
  25. 1peg: Structural Basis for The Product Specificity of Histone Lysine Methyltransferases
  26. 3hna: Crystal Structure of Catalytic Domain of Human Euchromatic Histone Methyltransferase 1 in Complex with Sah and Mono- Methylated H3K9 Peptide
  27. 3fpd: G9A-LIKE Protein Lysine Methyltransferase Inhibition by Bix- 01294
  28. 3f9z: Structural Insights into Lysine Multiple Methylation by Set Domain Methyltransferases, SET8-Y245F / H4-lys20 / Adohcy
  29. 3f9y: Structural Insights into Lysine Multiple Methylation by Set Domain Methyltransferases, SET8-Y334F / H4-LYS20ME1 / Adohcy
  30. 3f9x: Structural Insights into Lysine Multiple Methylation by Set Domain Methyltransferases, SET8-Y334F / H4-LYS20ME2 / Adohcy
  31. 3f9w: Structural Insights into Lysine Multiple Methylation by Set Domain Methyltransferases, SET8-Y334F / H4-lys20 / Adohcy
  32. 3f2k: Structure of The Transposase Domain of Human Histone-lysine N-methyltransferase Setmar
  33. 1u2z: Crystal Structure of Histone K79 Methyltransferase DOT1P from Yeast
  34. 3dlm: Crystal Structure of Tudor Domain of Human Histone-lysine N- Methyltransferase Setdb1
  35. 3cbp: Set7/9-er-sinefungin Complex
  36. 3cbo: Set7/9-er-adohcy Complex
  37. 3cbm: Set7/9-er-adomet Complex
  38. 3bo5: Crystal Structure of Methyltransferase Domain of Human Histone-lysine N-methyltransferase Setmar
  39. 3b7b: Euhmt1 (glp) Ankyrin Repeat Domain (structure 1)
  40. 2yuk: Solution Structure of The Hmg Box of Human Myeloid/lymphoid or Mixed-lineage Leukemia Protein 3 Homolog
  41. 2ysm: Solution Structure of The First and Second Phd Domain from Myeloid/lymphoid or Mixed-lineage Leukemia Protein 3 Homolog
  42. 1xqh: Crystal Structure of a Ternary Complex of The Methyltransferase Set9 (also Known as Set7/9) with a P53 Peptide and Sah
  43. 2w5z: Ternary Complex of The Mixed Lineage Leukaemia (mll1) Set Domain with The Cofactor Product S-adenosylhomocysteine and Histone Peptide.
  44. 2w5y: Binary Complex of The Mixed Lineage Leukaemia (mll1) Set Domain with The Cofactor Product S-adenosylhomocysteine.
  45. 1zkk: Crystal Structure of Hset8 in Ternary Complex with H4 Peptide (16-24) and Adohcy
  46. 2rfi: Crystal Structure of Catalytic Domain of Human Euchromatic Histone Methyltransferase 1 in Complex with Sah and Dimethylated H3K9 Peptide
  47. 2bqz: Crystal Structure of a Ternary Complex of The Human Histone Methyltransferase Pr-set7 (also Known as Set8)
  48. 2r3a: Methyltransferase Domain of Human Suppressor of Variegation 3-9 Homolog 2
  49. 2qxv: Structural Basis of Ezh2 Recognition by Eed
  50. 2o8j: Human Euchromatic Histone Methyltransferase 2
  51. 6c24: Cryo-em Structure of Prc2 Bound to Cofactors Aebp2 and Jarid2 in The Extended Active State
  52. 6c23: Cryo-em Structure of Prc2 Bound to Cofactors Aebp2 and Jarid2 in The Compact Active State
  53. 6by9: Crystal Structure of Ehmt1
  54. 6bx3: Structure of Histone H3K4 Methyltransferase
  55. 6bpi: Crystal Structure of Setdb1 Tudor Domain with Aryl Triazole Fragment Peptide Conjugates
  56. 6bp4: Structure of The S. Pombe Clr4 Catalytic Domain Bound to Sam
  57. 6boz: Structure of Human Setd8 in Complex with Covalent Inhibitor Ms4138
  58. 6box: Structure of The S. Pombe Clr4 Catalytic Domain Bound to Sah
  59. 6bhi: Crystal Structure of Setdb1 with a Modified H3 Peptide
  60. 6bhh: Crystal Structure of Setdb1 with a Modified H3 Peptide
  61. 6bhg: Crystal Structure of Setdb1 with a Modified H3 Peptide
  62. 6bhe: Crystal Structure of Setdb1 with a Modified H3 Peptide
  63. 6bhd: Crystal Structure of Setdb1 with a Modified H3 Peptide
  64. 6au3: Crystal Structure of Setdb1 Tudor Domain with Aryl Triazole Fragments
  65. 6au2: Crystal Structure of Setdb1 Tudor Domain with Aryl Triazole Fragments
  66. 6ago: Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex
  67. 6a5n: Crystal Structure of Arabidopsis Thaliana Suvh6 in Complex with Methylated Dna
  68. 6a5m: Crystal Structure of Arabidopsis Thaliana Suvh6 in Complex with Sam, Form 2
  69. 6a5k: Crystal Structure of Arabidopsis Thaliana Suvh6 in Complex with Sam, Form 1
  70. 2f69: Ternary Complex of Set7/9 Bound to Adohcy and a Taf10 Peptide
  71. 5yvx: Crystal Structure of Sdg8 Cw Domain in Complex with H3K4ME1 Peptide
  72. 5ylt: Crystal Structure of Set7/9 in Complex with a Cyproheptadine Derivative
  73. 6ten: Crystal Structure of DOT1L in Complex with an Inhibitor (compound 11).
  74. 6tel: Crystal Structure of DOT1L in Complex with an Inhibitor (compound 10).
  75. 6te6: Crystal Structure of DOT1L in Complex with an Inhibitor (compound 3).
  76. 2igq: Human Euchromatic Histone Methyltransferase 1
  77. 2j8a: X-ray Structure of The N-terminus Rrm Domain of Set1
  78. 6u9r: Mll1 Set N3861I/Q3867L Bound to Inhibitor 12 (tc-5140)
  79. 6u9n: Mll1 Set N3861I/Q3867L Bound to Inhibitor 14 (tc-5139)
  80. 6u9m: Mll1 Set N3861I/Q3867L Bound to Inhibitor 16 (tc-5109)
  81. 6u9k: Mll1 Set N3861I/Q3867L Bound to Inhibitor 18 (tc-5153)
  82. 6u4y: Crystal Structure of an Ezh2-eed Complex in an Oligomeric State
  83. 6t69: Crystal Structure of Toxoplasma Gondii Morn1(v Shape)
  84. 6sqk: Crystal Structure of Mouse Prmt6 with Modified H7-4 Peptide
  85. 2kkf: Solution Structure of Mll Cxxc Domain in Complex with Palindromic Cpg Dna
  86. 6kqq: Nsd1 Set Domain in Complex with Bt3 and Sam
  87. 3p4f: Structural and Biochemical Insights into Mll1 Core Complex Assembly and Regulation.
  88. 3ooi: Crystal Structure of Human Histone-lysine N-methyltransferase Nsd1 Set Domain in Complex with S-adenosyl-l-methionine
  89. 3ope: Structural Basis of Auto-inhibitory Mechanism of Histone Methyltransferase
  90. 3os5: Set7/9-dnmt1 K142ME1 Complex
  91. 3oxf: Human Lysine Methyltransferase Smyd3 in Complex with Adohcy (form I)
  92. 3oxg: Human Lysine Methyltransferase Smyd3 in Complex with Adohcy (form Iii)
  93. 3oxl: Human Lysine Methyltransferase Smyd3 in Complex with Adohcy (form Ii)
  94. 3q0b: Crystal Structure of Suvh5 Sra- Fully Methylated Cg Dna Complex in Space Group P42212
  95. 3q0c: Crystal Structure of Suvh5 Sra-fully Methylated Cg Dna Complex in Space Group P6122
  96. 3q0d: Crystal Structure of Suvh5 Sra- Hemi Methylated Cg Dna Complex
  97. 3q0f: Crystal Structure of Suvh5 Sra- Methylated Chh Dna Complex
  98. 3qwp: Crystal Structure of Set and Mynd Domain Containing 3; Zinc Finger Mynd Domain-containing Protein 1
  99. 3rjw: Crystal Structure of Histone Lysine Methyltransferase G9A with an Inhibitor
  100. 2l7p: Ashh2 a Cw Domain
  101. 3qow: DOT1L Structure in Complex with Sam
  102. 3qox: DOT1L Structure in Complex with Sah
  103. 3ru0: Cocrystal Structure of Human Smyd3 with Inhibitor Sinefungin Bound
  104. 6o9o: Crystal Structure of Smyd3 with Potent and Selective Isoxazole Amide Inhibitor 1
  105. 3rib: Human Lysine Methyltransferase Smyd2 in Complex with Adohcy
  106. 3rq4: Crystal Structure of Suppressor of Variegation 4-20 Homolog 2
  107. 3s8p: Crystal Structure of The Set Domain of Human Histone-lysine N- Methyltransferase SUV420H1 in Complex with S-adenosyl-l-methionine
  108. 3smt: Crystal Structure of Human Set Domain-containing Protein3
  109. 3sx0: Crystal Structure of DOT1L in Complex with a Brominated Sah Analog
  110. 3s7b: Structural Basis of Substrate Methylation and Inhibition of Smyd2
  111. 3s7d: Structural Basis of Substrate Methylation and Inhibition of Smyd2
  112. 3s7f: Structural Basis of Substrate Methylation and Inhibition of Smyd2
  113. 3s7j: Structural Basis of Substrate Methylation and Inhibition of Smyd2
  114. 6pww: Cryo-em Structure of Mll1 in Complex with Rbbp5 and Wdr5 Bound to The Nucleosome
  115. 6pwv: Cryo-em Structure of Mll1 in Complex with Rbbp5 and Wdr5 Bound to The Nucleosome
  116. 3tg4: Structure of Smyd2 in Complex with Sam
  117. 3tg5: Structure of Smyd2 in Complex with P53 and Sah
  118. 6uh5: Structural Basis of Compass Ecm Recognition of The H2BUB Nucleosome
  119. 6ugm: Structural Basis of Compass Ecm Recognition of an Unmodified Nucleosome
  120. 6ue6: Pwwp1 Domain of Nsd2 in Complex with Mr837
  121. 3sr4: Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor
  122. 3sw9: Glp (G9A-LIKE Protein) Set Domain in Complex with DNMT3AK44ME0 Peptide
  123. 3swc: Glp (G9A-LIKE Protein) Set Domain in Complex with DNMT3AK44ME2 Peptide
  124. 6qxz: Solution Structure of The Ashh2 Cw Domain with The N-terminal Histone H3 Tail Mimicking Peptide Monomethylated on Lysine 4
  125. 3uvk: Crystal Structure of Wdr5 in Complex with The Wdr5-interacting Motif of Mll2
  126. 3uvl: Crystal Structure of Wdr5 in Complex with The Wdr5-interacting Motif of Mll3
  127. 3uvm: Crystal Structure of Wdr5 in Complex with The Wdr5-interacting Motif of Mll4
  128. 3uvn: Crystal Structure of Wdr5 in Complex with The Wdr5-interacting Motif of SET1A
  129. 3uvo: Crystal Structure of Wdr5 in Complex with The Wdr5-interacting Motif of SET1B
  130. 6px3: Set2 Bound to Nucleosome
  131. 3u85: Crystal Structure of Human Menin in Complex with Mll1
  132. 3u88: Crystal Structure of Human Menin in Complex with Mll1 and Ledgf
  133. 6p0r: Methyltransferase Domain of Human Suppressor of Variegation 3-9 Homolog 2 (SUV39H2) in Complex with Ots186935 Inhibitor
  134. 3uwp: Crystal Structure of DOT1L in Complex with 5-iodotubercidin
  135. 6o96: DOT1L Bound to The H2BK120 Ubiquitinated Nucleosome
  136. 6o7g: Solution Structure of Mll4 Phd6 Domain in Complex with Histone H4K16AC Peptide
  137. 4e47: Set7/9 in Complex with Inhibitor (r)-(3-(3-cyanophenyl)-1-oxo-1- (pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6- Sulfonamide and S-adenosylmethionine
  138. 6nzo: Set2 Bound to Nucleosome
  139. 6nqa: Active State DOT1L Bound to The H2B-UBIQUITINATED Nucleosome, 1-to-1 Complex
  140. 6nog: Poised-state DOT1L Bound to The H2B-UBIQUITINATED Nucleosome
  141. 6nn6: Structure of DOT1L-H2BK120UB Nucleosome Complex
  142. 6nm4: Crystal Structure of Sam-bound Prdm9 in Complex with Mrk-740 Inhibitor
  143. 6nj9: Active State DOT1L Bound to The H2B-UBIQUITINATED Nucleosome, 2-to-1 Complex
  144. 4eqz: Crystal Structure of Human DOT1L in Complex with Inhibitor Fed2
  145. 4er0: Crystal Structure of Human DOT1L in Complex with Inhibitor Fed1
  146. 4er3: Crystal Structure of Human DOT1L in Complex with Inhibitor Epz004777
  147. 4er5: Crystal Structure of Human DOT1L in Complex with 2 Molecules of Epz004777
  148. 4er6: Crystal Structure of Human DOT1L in Complex with Inhibitor Sgc0946
  149. 4er7: Crystal Structure of Human DOT1L in Complex with Inhibitor Sgc0947
  150. 4erq: X-ray Structure of Wdr5-mll2 Win Motif Peptide Binary Complex
  151. 4ery: X-ray Structure of Wdr5-mll3 Win Motif Peptide Binary Complex
  152. 4erz: X-ray Structure of Wdr5-mll4 Win Motif Peptide Binary Complex
  153. 4es0: X-ray Structure of WDR5-SETD1B Win Motif Peptide Binary Complex
  154. 4esg: X-ray Structure of Wdr5-mll1 Win Motif Peptide Binary Complex
  155. 4ewr: X-ray Structure of WDR5-SETD1A Win Motif Peptide Binary Complex
  156. 6n3g: Crystal Structure of Histone Lysine Methyltransferase Smyd2 in Complex with Polyethylene Glycol
  157. 6mon: Crystal Structure of Human Smyd2 in Complex with Nle-peptide Inhibitor
  158. 6mm1: Structure of The Cysteine-rich Region from Human Ehmt2
  159. 6mlc: Phd6 Domain of Mll3 in Complex with Histone H4
  160. 6mbp: Glp Methyltransferase with Inhibitor Eml741- P3121 Crystal Form
  161. 6mbo: Glp Methyltransferase with Inhibitor Eml741-p212121 Crystal Form
  162. 6mbl: Setd3, a Histidine Methyltransferase, in Complex with an Actin Peptide and Sah, Second P212121 Crystal Form
  163. 6mbk: Setd3, a Histidine Methyltransferase, in Complex with an Actin Peptide and Sah, First P212121 Crystal Form
  164. 6mbj: Setd3, a Histidine Methyltransferase, in Complex with an Actin Peptide and Sah, P21 Crystal Form
  165. 6kiz: Cryo-em Structure of Human Mll1-ncp Complex, Binding Mode2
  166. 6kix: Cryo-em Structure of Human Mll1-ncp Complex, Binding Mode1
  167. 6kiw: Cryo-em Structure of Human Mll3-ubncp Complex (4.0 Angstrom)
  168. 6kiv: Cryo-em Structure of Human Mll1-ubncp Complex (4.0 Angstrom)
  169. 6kiu: Cryo-em Structure of Human Mll1-ubncp Complex (3.2 Angstrom)
  170. 2lv9: Solution Nmr Structure of The Phd Domain of Human Mll5, Northeast Structural Genomics Consortium Target HR6512A
  171. 6jn2: Crystal Structure of The Coiled-coil Domains of Human DOT1L in Complex with Af10
  172. 6jma: Cryo-em Structure of DOT1L Bound to H2B Ubiquitinated Nucleosome
  173. 6jm9: Cryo-em Structure of DOT1L Bound to Unmodified Nucleosome
  174. 6j99: Cryo-em Structure of Human DOT1L in Complex with an H2B- Monoubiquitinated Nucleosome
  175. 4fmu: Crystal Structure of Methyltransferase Domain of Human Set Domain- Containing Protein 2 Compound: Pr-snf
  176. 4gq6: Human Menin
  177. 6ine: Crystal Structure of Human ASH1L-MRG15 Complex
  178. 6in3: Crystal Structure of DOT1L in Complex with 18-crown-6
  179. 4ek9: Crystal Structure of DOT1L in Complex with Epz000004
  180. 4ekg: Crystal Structure of DOT1L in Complex with Epz003696
  181. 4eki: Crystal Structure of DOT1L in Complex with Epz004777
  182. 6ijl: Crystal Structure of Smyd3 in Complex with Covalent Inhibitor 5
  183. 4h12: The Crystal Structure of Methyltransferase Domain of Human Set Domain- Containing Protein 2 in Complex with S-adenosyl-l-homocysteine
  184. 6icv: Structure of Setd3 Bound to Sah and Unmodified Actin
  185. 6ict: Structure of Setd3 Bound to Sah and Methylated Actin
  186. 4gnd: Crystal Structure of Nsd3 Tandem PHD5-C5HCH Domains
  187. 4gne: Crystal Structure of Nsd3 Tandem PHD5-C5HCH Domains Complexed with H3 Peptide 1-7
  188. 4gnf: Crystal Structure of Nsd3 Tandem PHD5-C5HCH Domains Complexed with H3 Peptide 1-15
  189. 4gng: Crystal Structure of Nsd3 Tandem PHD5-C5HCH Domains Complexed with H3K9ME3 Peptide
  190. 4i51: Methyltransferase Domain of Human Euchromatic Histone Methyltransferase 1, Mutant Y1211A
  191. 4ij8: Crystal Structure of The Complex of Setd8 with Sam
  192. 4ijd: Crystal Structure of Methyltransferase Domain of Human Pr Domain- Containing Protein 9
  193. 3vuz: Crystal Structure of Histone Methyltransferase Set7/9 in Comlex with Aam-1
  194. 3vv0: Crystal Structure of Histone Methyltransferase Set7/9 in Comlex with Daam-3
  195. 4jds: Setd7 in Complex with Inhibitor Pf-5426 and S-adenosyl-methionine
  196. 4jlg: Setd7 in Complex with Inhibitor (r)-pfi-2 and S-adenosyl-homocysteine
  197. 2lxs: Allosteric Communication in The Kix Domain Proceeds through Dynamic Re-packing of The Hydrophobic Core
  198. 2lxt: Allosteric Communication in The Kix Domain Proceeds through Dynamic Re-packing of The Hydrophobic Core
  199. 6g3t: X-ray Structure of Nsd3-pwwp1
  200. 6g3p: X-ray Structure of Seleno-methionine Labelled Nsd3-pwwp1
  201. 6g2o: X-ray Structure of Nsd3-pwwp1 in Complex with Compound Bi-9321
  202. 6g2f: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 16
  203. 6g2e: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 13
  204. 6g2c: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 9
  205. 6g2b: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 8
  206. 6g29: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 6
  207. 6g27: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 5
  208. 6g25: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 4
  209. 6g24: X-ray Structure of Nsd3-pwwp1 in Complex with Compound 3
  210. 4au7: The Structure of The Suv4-20h2 Ternary Complex with Histone H4
  211. 4l58: Crystal Structure of The Mll5 Phd Finger in Complex with H3K4ME3
  212. 6emq: Solution Structure of The Ledgf/p75 Ibd - Mll1 (aa 111-160) Complex
  213. 4hra: Crystal Structure of DOT1L in Complex with Epz-5676
  214. 6jat: Crystal Structure of Setd3 Bound to Actin Peptide and Sfg
  215. 2lxe: S4WYILD
  216. 2mdc: Solution Structure of The Ww Domain of Hypb
  217. 2mdi: Solution Structure of The PP2WW Mutant (KPP2WW) of Hypb
  218. 2mdj: Solution Structure of Ww Domain with Polyproline Stretch (PP2WW) of Hypb
  219. 6cko: Crystal Structure of an Af10 Fragment
  220. 6chg: Crystal Structure of The Yeast Compass Catalytic Module
  221. 6cen: Crystal Structure of WHSC1L1 in Complex with Inhibitor Pep21
  222. 6cby: Crystal Structure of Human Set and Mynd Domain Containing Protein 2 with Mtf9975
  223. 6cbx: Crystal Structure of Human Set and Mynd Domain Containing Protein 2 with Mtf1497
  224. 4bup: A Novel Route to Product Specificity in The Suv4-20 Family of Histone H4K20 Methyltransferases
  225. 6p6g: Co-crystal Structure of Human Smyd3 with Isoxazole Amides Inhibitors
  226. 6p6k: Co-crystal Structure of Human Smyd3 with Isoxazole Amides Inhibitors
  227. 6p7z: Co-crystal Structure of Human Smyd3 with Isoxazole Amides Inhibitors
  228. 6paf: Co-crystal Structure of Human Smyd3 with Isoxazole Amides Inhibitors
  229. 4c1q: Crystal Structure of The Prdm9 Set Domain in Complex with H3K4ME2 and Adohcy.
  230. 4j7f: SET7/9Y335PAF in Complex with Taf10 Peptide and Adohcy
  231. 4j7i: SET7/9Y335F in Complex with Taf10 Peptide and Adohcy
  232. 4j83: Set7/9 in Complex with TAF10K189A Peptide and Adomet
  233. 4j8o: Set7/9 in Complex with TAF10K189A Peptide and Adohcy
  234. 4mi0: Human Enhancer of Zeste (drosophila) Homolog 2(ezh2)
  235. 4mi5: Crystal Structure of The Ezh2 Set Domain
  236. 4nj5: Crystal Structure of Suvh9
  237. 4nvq: Human G9A in Complex with Inhibitor A-366
  238. 4o30: Crystal Structure of Atxr5 in Complex with Histone H3.1 and Adohcy
  239. 4o6f: Structural Basis of Estrogen Receptor Alpha Methylation Mediated by Histone Methyltransferase Smyd2
  240. 5yjo: Crystal Structure of Smyd3 in Complex with Covalent Inhibitor 4
  241. 4pzi: Zinc Finger Region of Mll2 in Complex with Cpg Dna
  242. 4qen: Crystal Structure of Kryptonite in Complex with Mchh Dna and Sah
  243. 4qeo: Crystal Structure of Kryptonite in Complex with Mchh Dna, H3(1-15) Peptide and Sah
  244. 4qep: Crystal Structure of Kryptonite in Complex with Mchg Dna and Sah
  245. 5ww0: Crystal Structure of Set7, a Novel Histone Methyltransferase in Schizossacharomyces Pombe
  246. 5wuk: Crystal Structure of Eed [G255D] in Complex with Ezh2 Peptide and Eed226 Compound
  247. 5wg6: Human Polycomb Repressive Complex 2 in Complex with Gsk126 Inhibitor
  248. 5wcg: Set and Mynd Domain Containing Protein 2
  249. 5wbv: Crystal Structure of The Set Domain of Human SUV420H1 in Complex with Inhibitor
  250. 5w1y: Setd8 in Complex with a Covalent Inhibitor
  251. 5vsf: Structure of Human Glp Set-domain (ehmt1) in Complex with Inhibitor 17
  252. 5vse: Structure of Human G9A Set-domain (ehmt2) in Complex with Inhibitor 17: N~2~-cyclopentyl-6,7-dimethoxy-n~2~-methyl-n~4~-(1- Methylpiperidin-4-yl)quinazoline-2,4-diamine
  253. 5vsd: Structure of Human Glp Set-domain (ehmt1) in Complex with Inhibitor 13
  254. 5vsc: Structure of Human G9A Set-domain (ehmt2) in Complex with Inhibitor 13
  255. 5vc8: Crystal Structure of The Whsc1 Pwwp1 Domain
  256. 5vbc: Crystal Structure of Atxr5 in Complex with Histone H3.1
  257. 5vah: Crystal Structure of Atxr5 Set Domain in Complex with Histone H3 Di- Methylated on R26
  258. 5vac: Crystal Structure of Atxr5 Set Domain in Complex with K36ME3 Histone H3 Peptide
  259. 5va6: Crystal Structure of Atxr5 in Complex with Histone H3.1 Mono- Methylated on R26
  260. 5v9j: Crystal Structure of Catalytic Domain of Glp with Ms0105
  261. 5v9i: Crystal Structure of Catalytic Domain of G9A with Ms0105
  262. 5v3h: Crystal Structure of Smyd2 with Sam and Epz033294
  263. 5v3g: Prdm9-allele-c Znf8-13
  264. 5v37: Crystal Structure of Smyd3 with Sam and Epz028862
  265. 5v2n: Crystal Structure of Apo Human Setd8
  266. 5v22: Crystal Structure of Human Setd2 Set-domain in Complex with H3K36M Peptide and Sah
  267. 5v21: Crystal Structure of Human Setd2 Set-domain in Complex with H3K36M Peptide and Sam
  268. 2mtn: Solution Structure of Mll-ibd Complex
  269. 5upd: Methyltransferase Domain of Human Wolf-hirschhorn Syndrome Candidate 1-like Protein 1 (WHSC1L1)
  270. 4wvl: Structure-guided DOT1L Probe Optimization by Label-free Ligand Displacement
  271. 5u62: Crystal Structure of Eed in Complex with H3K27ME3 Peptide and 6- (benzo[d][1,3]dioxol-4-ylmethyl)-5,6,7,8-tetrahydroimidazo[1,5- A]pyridin-3-amine
  272. 5u5t: Crystal Structure of Eed in Complex with H3K27ME3 Peptide and 3- (benzo[d][1,3]dioxol-4-ylmethyl)piperidine-1-carboximidamide
  273. 5tuz: Structure of Human Glp Set-domain (ehmt1) in Complex with Inhibitor Ms0124
  274. 5tuy: Structure of Human G9A Set-domain (ehmt2) in Complex with Inhibitor Ms0124
  275. 5ttg: Crystal Structure of Catalytic Domain of Glp with Ms012
  276. 5ttf: Crystal Structure of Catalytic Domain of G9A with Ms012
  277. 5th7: Complex of Setd8 with Ms453
  278. 5tfp: Crystal Structure of The Setdb2 Amino Terminal Domain
  279. 5teg: Crystal Structure of Hsetd8 in Complex with Histone H4K20 Norleucine Mutant Peptide and S-adenosylmethionine
  280. 5t5g: Human Setd8 in Complex with Ms2177
  281. 5t0m: A Histone H3K9M Mutation Traps Histone Methyltransferase Clr4 to Prevent Heterochromatin Spreading
  282. 5t0k: Structure of G9A Set-domain with H3K9M Mutant Peptide and Sam
  283. 5svh: Crystal Structure of The Kix Domain of Cbp in Complex with a Mll/c-myb Chimera
  284. 5qt2: Pandda Analysis Group Deposition -- Partial Occupancy Interpretation of Pandda Event Map: Setdb1 in Complex with FMOPL000074A
  285. 5qt1: Pandda Analysis Group Deposition -- Partial Occupancy Interpretation of Pandda Event Map: Setdb1 in Complex with FMOMB000017A
  286. 5mw4: Crystal Structure of DOT1L in Complex with Inhibitor Cpd7 [n-(3-(((r)- 1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)(methyl)amino) Propyl)-2-(3-(2-chloro-3-(2-methylpyridin-3-yl)benzo[b]thiophen-5- Yl)ureido)acetamide]
  287. 5mw3: Crystal Structure of DOT1L in Complex with Inhibitor Cpd1 [n6-(2,6- Dichlorophenyl)-n6-(pent-2-yn-1-yl)quinoline-4,6-diamine] and Inhibitor Cpd2 [(r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3- Amine]
  288. 5mvs: Crystal Structure of DOT1L in Complex with Adenosine and Inhibitor Cpd1 [n6-(2,6-dichlorophenyl)-n6-(pent-2-yn-1-yl)quinoline-4,6- Diamine]
  289. 5lt8: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
  290. 5lt7: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
  291. 5lt6: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
  292. 5lsz: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
  293. 5lsy: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
  294. 5lsx: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
  295. 5lsu: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
  296. 5lss: Structure of The Epigenetic Oncogene Mmset and Inhibition by N-alkyl Sinefungin Derivatives
  297. 5ls6: Structure of Human Polycomb Repressive Complex 2 (prc2) with Inhibitor
  298. 5kjn: Smyd2 in Complex with Az506
  299. 5kjm: Smyd2 in Complex with Az931
  300. 5kjl: Smyd2 in Complex with Az378
  301. 5kjk: Smyd2 in Complex with Az370
  302. 5kh6: Setdb1 in Complex with a Fragment Candidate
  303. 5kco: Setdb1 in Complex with an Early Stage, Low Affinity Fragment Candidate Modelled at Reduced Occupancy
  304. 5kch: Setdb1 in Complex with an Early Stage, Low Affinity Fragment Candidate Modelled at Reduced Occupancy into Weak Electron Density
  305. 5juw: Complex of DOT1L with Ss148
  306. 5jle: Crystal Structure of Setd2 Bound to Sah
  307. 5jlb: Crystal Structure of Setd2 Bound to Histone H3.3 K36I Peptide
  308. 5jjy: Crystal Structure of Setd2 Bound to Histone H3.3 K36M Peptide
  309. 5jj0: Structure of G9A Set-domain with Histone H3K9M Peptide and Excess Sah
  310. 5jiy: Structure of G9A Set-domain with Histone H3K9NORLEUCINE Mutant Peptide and Bound S-adenosylmethionine
  311. 5jin: Structure of G9A Set-domain with Histone H3K9M Mutant Peptide and Bound S-adenosylmethionine
  312. 5jhn: Structure of G9A Set-domain with Histone H3K9ALA Mutant Peptide and Bound S-adenosylmethionine
  313. 5ij8: Structure of The Primary Oncogenic Mutant Y641N Hs/acprc2 in Complex with a Pyridone Inhibitor
  314. 5ij7: Structure of Hs/acprc2 in Complex with a Pyridone Inhibitor
  315. 5hyn: Structure of Human Polycomb Repressive Complex 2 (prc2) with Oncogenic Histone H3K27M Peptide
  316. 5ht6: Crystal Structure of The Set Domain of The Human Mll5 Methyltransferase
  317. 5hq8: Co-crystal Structure of Human Smyd3 with a Mekk2 Peptide at 2.13a
  318. 5hq2: Structural Model of Set8 Histone H4 Lys20 Methyltransferase Bound to Nucleosome Core Particle
  319. 5hi7: Co-crystal Structure of Human Smyd3 with an Aza-sah Compound
  320. 5h6z: Crystal Structure of Set7, a Novel Histone Methyltransferase in Schizossacharomyces Pombe
  321. 5h25: Eed in Complex with Prc2 Allosteric Inhibitor Compound 11
  322. 5h24: Eed in Complex with Prc2 Allosteric Inhibitor Compound 8
  323. 5h19: Eed in Complex with Prc2 Allosteric Inhibitor Eed162
  324. 5h17: Eed in Complex with Prc2 Allosteric Inhibitor Eed210
  325. 5h15: Eed in Complex with Prc2 Allosteric Inhibitor Eed709
  326. 5h14: Eed in Complex with an Allosteric Prc2 Inhibitor Eed666
  327. 5gsa: Eed in Complex with an Allosteric Prc2 Inhibitor
  328. 5f6l: The Crystal Structure of Mll1 (N3861I/Q3867L) in Complex with Rbbp5 and ASH2L
  329. 5f6k: Crystal Structure of The MLL3-ASH2L-RBBP5 Complex
  330. 5f5e: The Crystal Structure of Mll1 Set Domain with N3816I/Q3867L Mutation
  331. 5f59: The Crystal Structure of Mll3 Set Domain
  332. 5ex3: Crystal Structure of Human Smyd3 in Complex with a Vegfr1 Peptide
  333. 5ex0: Crystal Structure of Human Smyd3 in Complex with a MAP3K2 Peptide
  334. 5ei9: Human Prdm9 Allele-a Znf Domain with Associated Recombination Hotspot Dna Sequence I
  335. 5eh2: Human Prdm9 Allele-a Znf Domain with Associated Recombination Hotspot Dna Sequence III
  336. 5egb: Human Prdm9 Allele-a Znf Domain with Associated Recombination Hotspot Dna Sequence II
  337. 5eg2: Set7/9 N265A in Complex with Adohcy and Taf10 Peptide
  338. 5dtr: Crystal Structure of DOT1L in Complex with Inhibitor Cpd5 [n-(2,6- Dichlorophenyl)-4-methoxy-n-methylquinolin-6-amine]
  339. 5dtq: Crystal Structure of DOT1L in Complex with Inhibitor Cpd3 [(2,6- Dichlorophenyl)(quinolin-6-yl)methanone]
  340. 5dtm: Crystal Structure of DOT1L in Complex with Inhibitor Cpd1 [4-(2,6- Dichlorobenzoyl)-n-methyl-1h-pyrrole-2-carboxamide]
  341. 5dt2: Crystal Structure of DOT1L in Complex with Inhibitor Cpd11 [n4-methyl- N2-(2-methyl-1-(2-phenoxyphenyl)-1h-indol-6-yl)pyrimidine-2,4- Diamine]
  342. 5dsx: Crystal Structure of DOT1L in Complex with Inhibitor Cpd10 [6'-chloro- 1,4-dimethyl-5'-(2-methyl-6-((4-(methylamino)pyrimidin-2-yl)amino)- 1h-indol-1-yl)-[3,3'-bipyridin]-2(1h)-one]
  343. 5dry: Crystal Structure of DOT1L in Complex with Inhibitor Cpd3 [n-(1-(2- Chlorophenyl)-1h-indol-6-yl)-2-(2-(5-(2-chlorophenyl)-1h-tetrazol-1- Yl)acetyl)hydrazinecarboxamide]
  344. 5drt: Crystal Structure of DOT1L in Complex with Inhibitor Cpd2 [2-(2-(5- ((2-chlorophenoxy)methyl)-1h-tetrazol-1-yl)acetyl)-n-(4- Chlorophenyl)hydrazinecarboxamide]
  345. 5cpr: The Novel Suv4-20 Inhibitor A-196 Verifies a Role for Epigenetics in Genomic Integrity
  346. 5ccm: Crystal Structure of Smyd3 with Sam and Epz030456
  347. 5ccl: Crystal Structure of Smyd3 with Sam and Oxindole Compound
  348. 6j9j: Crystal Structure of Sestd2 in Complex with H3.3S31PHK36M Peptide
  349. 5ayf: Crystal Structure of Set7/9 in Complex with Cyproheptadine
  350. 5arg: Smyd2 in Complex with Sgc Probe Bay-598
  351. 5arf: Smyd2 in Complex with Small Molecule Inhibitor Compound-2
  352. 4rxj: Crystal Structure of WHSC1L1-PWWP2
  353. 4z4p: Structure of The Mll4 Set Domain
  354. 4wuy: Crystal Structure of Protein Lysine Methyltransferase Smyd2 in Complex with Lly-507, a Cell-active, Potent and Selective Inhibitor
  355. 4ypu: ASH1L Set Domain K2264L Mutant in Complex with S-adenosyl Methionine (sam)
  356. 4ype: ASH1L Set Domain H2193F Mutant in Complex with S-adenosyl Methionine (sam)
  357. 4ypa: ASH1L Set Domain Q2265A Mutant in Complex with S-adenosyl Methionine (sam)
  358. 2mv7: Solution Nmr Structure of DOT1L in Complex with Af9 (DOT1L-AF9)
  359. 4ynp: ASH1L Set Domain S2259M Mutant in Complex with S-adenosyl Methionine (sam)
  360. 4ynm: ASH1L Wild-type Set Domain in Complex with S-adenosyl Methionine (sam)
  361. 4ygi: Crystal Structure of Suvh5 Sra Bound to Fully Hydroxymethylated Cg Dna
  362. 4ynd: The Discovery of A-893, a New Cell-active Benzoxazinone Inhibitor of Lysine Methyltransferase Smyd2
  363. 2naa: NSD1-PHD_5-C5HCH Tandem Domain Structure
  364. 2ncz: Solution Nmr Structures of Brd4 Et Domain in Complex with Nsd3_1 Peptide
  365. 2nd1: Solution Nmr Structures of Brd4 Et Domain in Complex with Nsd3_3 Peptide
© Copyright 2008-2009 by enzymes.me.uk