EC 2.1.1.45 - 5,10- methylenetetrahydrofolate:dUMP C- methyltransferase (thymidylate synthase)

3D structures of EC 2.1.1.45 - thymidylate synthase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1aiq: Crystal Structure of Thymidylate Synthase R126E Mutant
2. 1ajm: Crystal Structure of Thymidylate Synthase R126E Mutant
3. 1an5: E. Coli Thymidylate Synthase in Complex with Cb3717
4. 1aob: E. Coli Thymidylate Synthase Complexed with Ddurd
5. 1axw: E. Coli Thymidylate Synthase in Complex with Methotrexate (mtx) and 2'-deoxyuridine 5'-monophosphate (dump)
6. 1b02: Crystal Structure of Thymidylate Synthase a from Bacillus Subtilis
7. 1bdu: E. Coli Thymidylate Synthase Complexed with Durd
8. 1bid: E. Coli Thymidylate Synthase Complexed with Dump
9. 1bjg: D221(169)n Mutant Does Not Promote Opening of The Cofactor Imidazolidine Ring
10. 1bko: Thermostable Thymidylate Synthase a from Bacillus Subtilis
11. 1bkp: Thermostable Thymidylate Synthase a from Bacillus Subtilis
12. 1bo7: Thymidylate Synthase R179T Mutant
13. 1bo8: Thymidylate Synthase R178T Mutant
14. 1bp0: Thymidylate Synthase R23I Mutant
15. 1bp6: Thymidylate Synthase R23I, R179T Double Mutant
16. 1bpj: Thymidylate Synthase R178T, R179T Double Mutant
17. 1bq1: E. Coli Thymidylate Synthase Mutant N177A in Complex with Cb3717 and 2'-deoxyuridine 5'-monophosphate (dump)
18. 1bq2: E. Coli Thymidylate Synthase Mutant N177A
19. 1bsf: Thermostable Thymidylate Synthase a from Bacillus Subtilis
20. 1bsp: Thermostable Thymidylate Synthase a from Bacillus Subtilis
21. 1ci7: Ternary Complex of Thymidylate Synthase from Pneumocystis Carinii
22. 1ddu: E. Coli Thymidylate Synthase in Complex with Cb3717 and 2', 5'-dideoxyuridine (ddurd)
23. 1dna: D221(169)n Mutant Does Not Promote Opening of The Cofactor Imidazolidine Ring
24. 1ev5: Crystal Structure Analysis of Ala167 Mutant of Escherichia Coli
25. 1ev8: Crystal Structure Analysis of Cys167 Mutant of Escherichia Coli
26. 1evf: Crystal Structure Analysis of Cys167 Mutant of Escherichia Coli
27. 1evg: Crystal Structure Analysis of Cys167 Mutant of Escherichia Coli with Unmodified Catalytic Cysteine
28. 1f28: Crystal Structure of Thymidylate Synthase from Pneumocystis Carinii Bound to Dump and BW1843U89
29. 1f4b: Crystal Structure of Escherichia Coli Thymidylate Synthase
30. 1f4c: Crystal Structure of E. Coli Thymidylate Synthase Covalently Modified at C146 with N-[tosyl-d-prolinyl]amino- Ethanethiol
31. 1f4d: Crystal Structure of E. Coli Thymidylate Synthase C146S, L143C Covalently Modified at C143 with N-[tosyl-d- Prolinyl]amino-ethanethiol
32. 1f4e: Crystal Structure of E. Coli Thymidylate Synthase Complexed with Tosyl-d-proline
33. 1f4f: Crystal Structure of E. Coli Thymidylate Synthase Complexed with Sp-722
34. 1f4g: Crystal Structure of E. Coli Thymidylate Synthase Complexed with Sp-876
35. 1ffl: Crystal Structure of The Apo-thymidylate Synthase R166Q Mutant
36. 1fwm: Crystal Structure of The Thymidylate Synthase R166Q Mutant
37. 1hvy: Human Thymidylate Synthase Complexed with Dump and Raltitrexed, an Antifolate Drug, Is in The Closed Conformation
38. 1hw3: Structure of Human Thymidylate Synthase Suggests Advantages of Chemotherapy with Noncompetitive Inhibitors
39. 1hw4: Structure of Thymidylate Synthase Suggests Advantages of Chemotherapy with Noncompetitive Inhibitors
40. 1hzw: Crystal Structure of Human Thymidylate Synthase
41. 1i00: Crystal Structure of Human Thymidylate Synthase, Ternary Complex with Dump and Tomudex
42. 1j3i: Wild-type Plasmodium Falciparum Dihydrofolate Reductase- Thymidylate Synthase (pfdhfr-ts) Complexed with Wr99210, Nadph, and Dump
43. 1j3j: Double Mutant (C59R+S108N) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts) Complexed with Pyrimethamine, Nadph, and Dump
44. 1j3k: Quadruple Mutant (N51I+C59R+S108N+I164L) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts) Complexed with Wr99210, Nadph, and Dump
45. 1jg0: Crystal Structure of Escherichia Coli Thymidylate Synthase Complexed with 2'-deoxyuridine-5'-monophosphate and N,o- Didansyl-l-tyrosine
46. 1jmf: Contributions of Orientation and Hydrogen Bonding to Catalysis in Asn-229 Mutants of Thymidylate Synthase
47. 1jmg: Contributions of Orientation and Hydrogen Bonding to Catalysis in Asn-229 Mutants of Thymidylate Synthase
48. 1jmh: Contributions of Orientation and Hydrogen Bonding to Catalysis in Asn-229 Mutants of Thymidylate Synthase
49. 1jmi: Contributions of Orientation and Hydrogen Bonding to Catalysis in Asn-229 Mutants of Thymidylate Synthase
50. 1jtq: E. Coli Ts Complex with Dump and The Pyrrolo(2,3-d) Pyrimidine-based Antifolate Ly341770
51. 1jtu: E. Coli Thymidylate Synthase in a Complex with Dump and Ly338913, a Polyglutamylated Pyrrolo(2,3-d)pyrimidine- Based Antifolate
52. 1ju6: Human Thymidylate Synthase Complex with Dump and Ly231514, a Pyrrolo(2,3-d)pyrimidine-based Antifolate
53. 1juj: Human Thymidylate Synthase Bound to Dump and Ly231514, a Pyrrolo(2,3-d)pyrimidine-based Antifolate
54. 1jut: E. Coli Thymidylate Synthase Bound to Dump and Ly338529, a Pyrrolo(2,3-d)pyrimidine-based Antifolate
55. 1kce: E. Coli Thymidylate Synthase Mutant E58Q in Complex with Cb3717 and 2'-deoxyuridine 5'-monophosphate (dump)
56. 4tms: Plastic Adaptation toward Mutations in Proteins: Structural Comparison of Thymidylate Synthases
57. 3tms: Plastic Adaptation toward Mutations in Proteins: Structural Comparison of Thymidylate Synthases
58. 1kzi: Crystal Structure of Ects/dump/thf Complex
59. 1kzj: Crystal Structure of Ects W80G/DUMP/CB3717 Complex
60. 1lca: Lactobacillus Casei Thymidylate Synthase Ternary Complex with Dump and Cb3717
61. 1lcb: Lactobacillus Casei Thymidylate Synthase Ternary Complex with Dtmp and H2FOLATE
62. 1lce: Lactobacillus Casei Thymidylate Synthase Ternary Complex with Dump and CH2THF
63. 3nrr: Co-crystal Structure of Dihydrofolate Reductase-thymidylate Synthase from Babesia Bovis with Dump, Raltitrexed and Nadp
64. 1nce: Crystal Structure of a Ternary Complex of E. Coli Thymidylate Synthase D169C with Dump and The Antifolate Cb3717
65. 1nja: Thymidylate Synthase, Mutation, N229C with 2'-deoxycytidine 5'-monophosphate (dcmp)
66. 1njb: Thymidylate Synthase
67. 1njc: Thymidylate Synthase, Mutation, N229D with 2'-deoxycytidine 5'-monophosphate (dcmp)
68. 1njd: Thymidylate Synthase, Mutation, N229D with 2'-deoxyuridine 5'-monophosphate (dump)
69. 1nje: Thymidylate Synthase with 2'-deoxycytidine 5'-monophosphate (dcmp)
70. 3kjs: Crystal Structure of T. Cruzi Dhfr-ts with 3 High Affinity Dhfr Inhibitors: Dq1 Inhibitor Complex
71. 3kjr: Crystal Structure of Dihydrofolate Reductase/thymidylate Synthase from Babesia Bovis Determined Using Slipchip Based Microfluidics
72. 3kgb: Crystal Structure of Thymidylate Synthase 1/2 from Encephalitozoon Cuniculi at 2.2 a Resolution
73. 3k2h: Co-crystal Structure of Dihydrofolate Reductase/thymidylate Synthase from Babesia Bovis with Dump, Pemetrexed and Nadp
74. 3jsu: Quadruple MUTANT(N51I+C59R+S108N+I164L) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase(pfdhfr-ts) Complexed with Qn254, Nadph, and Dump
75. 3ix6: Crystal Structure of Thymidylate Synthase Thya from Brucella Melitensis
76. 3iro: Trypanosoma Cruzi Dihydrofolate Reductase-thymidylate Synthase Complexed with Nadph and Q-8 Antifolate
77. 3irn: Trypanosoma Cruzi Dihydrofolate Reductase-thymidylate Synthase Complexed with Nadph and Cycloguanil
78. 3irm: Trypanosoma Cruzi Dihydrofolate Reductase-thymidylate Synthase Complexed with Cycloguanil
79. 3inv: Trypanosoma Cruzi Dihydrofolate Reductase-thymidylate Synthase Complexed with Nadph, Dump and C-448 Antifolate
80. 3ik1: Lactobacillus Casei Thymidylate Synthase in Ternary Complex with Dump and The Phtalimidic Derivative 20c
81. 3ik0: Lactobacillus Casei Thymidylate Synthase in Ternary Complex with Dump and The Phtalimidic Derivative 7c1
82. 3ijz: Lactobacillus Casei Thymidylate Synthase Ternary Complex with Dump and Pthalimidic Derivative 15c
83. 3ihi: Crystal Structure of Mouse Thymidylate Synthase
84. 3i3r: X-ray Structure Dihydrofolate Reductase/thymidylate Synthase from Babesia Bovis at 2.35a Resolution
85. 1qqq: Crystal Structure Analysis of Ser254 Mutant of Escherichia Coli Thymidylate Synthase
86. 3hbb: Structures of Dihydrofolate Reductase-thymidylate Synthase of Trypanosoma Cruzi in The Folate-free State and in Complex with Two Antifolate Drugs, Trimetrexate and Methotrexate
87. 3hb8: Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry
88. 3h9k: Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry
89. 1qzf: Crystal Structure of Dhfr-ts from Cryptosporidium Hominis
90. 3gh2: Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
91. 3gh0: Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
92. 3gg5: Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
93. 1rts: Thymidylate Synthase from Rat in Ternary Complex with Dump and Tomudex
94. 1sej: Crystal Structure of Dihydrofolate Reductase-thymidylate Synthase from Cryptosporidium Hominis Bound to 1843u89/nadph/dump
95. 1syn: E. Coli Thymidylate Synthase in Complex with BW1843U89 and 2'-deoxyuridine 5'-monophosphate (dump)
96. 1tda: Structures of Thymidylate Synthase with a C-terminal Deletion: Role of The C-terminus in Alignment of D/ump and CH2H4FOLATE
97. 1tdb: Structures of Thymidylate Synthase with a C-terminal Deletion: Role of The C-terminus in Alignment of D/ump and CH2H4FOLATE
98. 1tdc: Structures of Thymidylate Synthase with a C-terminal Deletion: Role of The C-terminus in Alignment of D/ump and CH2H4FOLATE
99. 1tdu: E. Coli Thymidylate Synthase in Complex with Cb3717 and 2'- Deoxyuridine (durd)
100. 3ejl: Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
101. 3ehi: Crystal Structure of Human Thymidyalte Synthase M190K with Loop 181-197 Stabilized in The Inactive Conformation
102. 3egy: Crystal Structure of Human Thymidyalte Synthase A191K with Loop 181-197 Stabilized in The Inactive Conformation
103. 1thy: Refined Structures of Substrate-bound and Phosphate-bound Thymidylate Synthase from Lactobacillus Casei
104. 3ef9: Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
105. 1tis: Crystal Structure of Thymidylate Synthase from T4 Phage
106. 1tjs: E. Coli Thymidylate Synthase
107. 3edw: Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
108. 3ed7: Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
109. 3ebu: Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
110. 1tlc: Thymidylate Synthase Complexed with Dgmp and Folate Analog 1843u89
111. 3eaw: Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
112. 1tls: Thymidylate Synthase Ternary Complex with Fdump and Methylenetetrahydrofolate
113. 1trg: E. Coli Thymidylate Synthase in Symmetric Complex with Cb3717 and 2'-deoxyuridine 5'-monophosphate (dump)
114. 1tsd: Thymidylate Synthase Complex with 2'-deoxyuridine 5'- Monophosphate (dump) and Folate Analog 1843u89
115. 1tsl: L. Casei Thymidylate Synthase with Species Specific Inhibitor
116. 1tsm: L. Casei Thymidylate Synthase with Species Specific Inhibitor
117. 1tsn: Thymidylate Synthase Ternary Complex with Fdump and Methylenetetrahydrofolate
118. 1tsv: Thymidylate Synthase R179A Mutant
119. 1tsw: Thymidylate Synthase R179A Mutant
120. 1tsx: Thymidylate Synthase R179E Mutant
121. 1tsy: Thymidylate Synthase R179K Mutant
122. 1tsz: Thymidylate Synthase R179K Mutant
123. 1tvu: Contributions of Orientation and Hydrogen Bonding to Catalysis in Asn-229 Mutants of Thymidylate Synthase
124. 1tvv: Contributions of Orientation and Hydrogen Bonding to Catalysis in Asn-229 Mutants of Thymidylate Synthase
125. 1tvw: Contributions of Orientation and Hydrogen Bonding to Catalysis in Asn-229 Mutants of Thymidylate Synthase
126. 1tys: Water-mediated Substrate(slash)product Discrimination: The Product Complex of Thymidylate Synthase at 1.83 Angstroms
127. 3dga: Wild-type Plasmodium Falciparum Dihydrofolate Reductase- Thymidylate Synthase (pfdhfr-ts) Complexed with Rjf01302, Nadph, and Dump
128. 3dg8: Quadruple Mutant (N51I+C59R+S108N+I164L) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts) Complexed with Rjf670, Nadph, and Dump
129. 3clb: Structure of Bifunctional Tcdhfr-ts in Complex with Tmq
130. 3cl9: Structure of Bifunctional Tcdhfr-ts in Complex with Mtx
131. 3c0a: Lactobacillus Casei Thymidylate Synthase Ternary Complex with Dump and The Phtalimidic Derivative 14c in Multiple Binding Modes-mode 2
132. 3c06: Lactobacillus Casei Thymidylate Synthase Ternary Complex with Dump and The Phtalimidic Derivative 14c in Multiple Binding Modes-mode 1
133. 3bz0: Lactobacillus Casei Thymidylate Synthase Ternary Complex with Dump and The Phtalimidic Derivative C00
134. 3byx: Lactobacillus Casei Thymidylate Synthase Ternary Complex with Dump and The Phtalimidic Derivative C00 in Multiple Binding Modes
135. 3bnz: Crystal Structure of Thymidylate Synthase Ternary Complex with Dump and 8a Inhibitor
136. 1vza: Thymidylate Synthase E60D Mutant Binary Complex with 2'- Deoxyuridine 5'-monophosphate (dump)
137. 1vzb: L. Casei Thymidylate Synthase Mutant E60Q Binary Complex with Dump
138. 1vzc: L. Casei Thymidylate Synthase Mutant E60Q Binary Complex with Fdump
139. 1vzd: L. Casei Thymidylate Synthase Mutant E60Q Ternary Complex with Fdump and Cb3717
140. 1vze: L. Casei Thymidylate Synthase Mutant E60Q Ternary Complex with Dump and Cb3717
141. 3bhr: E. Coli Ts Complexed with 5-NO2DUMP and Tetrahydrofolate at 1.9 a Resolution (space Group 152)
142. 3bhl: E.coli Thymidylate Synthase Complexes with 5-NO2DUMP and Tetrahydrofolate at 1.4 a Resolution
143. 3bgx: E. Coli Thymidylate Synthase C146S Mutant Complexed with Dtmp and Mtf
144. 3bfi: E. Coli Thymidylate Synthase Y209M Mutant Complexed with 5- Nitro-dump
145. 3b9h: E. Coli Thymidylate Synthase Complexed with 5-nitro-2'- Deoxy Uridine
146. 3b5b: Crystal Structure of The Thymidylate Synthase K48Q
147. 1ypv: Structure of Human Thymidylate Synthase at Low Salt Conditions
148. 1zpr: E. Coli Thymidylate Synthase Mutant E58Q in Complex with Cb3717 and 2'-deoxyuridine 5'-monophosphate (dump)
149. 2vf0: Crystal Structure of The Thymidylate Synthase K48Q Complexed with 5NO2DUMP and BW1843U89
150. 2vet: Crystal Structure of The Thymidylate Synthase K48Q Complexed with Dump
151. 2a9w: E. Coli Ts Complexed with Dump and Inhibitor Ga9
152. 2aaz: Cryptococcus Neoformans Thymidylate Synthase Complexed with Substrate and an Antifolate
153. 2tsr: Thymidylate Synthase from Rat in Ternary Complex with Dump and Tomudex
154. 2tsc: Structure, Multiple Site Binding, and Segmental Accomodation in Thymidylate Synthase on Binding D/ump and an Anti-folate
155. 2tdm: Structure of Thymidylate Synthase
156. 2tdd: Structures of Thymidylate Synthase with a C-terminal Deletion: Role of The C-terminus in Alignment of D/ump and CH2H4FOLATE
157. 2bbq: Structural Basis for Recognition of Polyglutamyl Folates by Thymidylate Synthase
158. 2rda: Human Thymidylate Synthase Stabilized in Active Conformation by R163K Mutation: Asymmetry and Reactivity of Cys195
159. 2rd8: Human Thymidylate Synthase Stabilized in Active Conformation by R163K Mutation: Asymmetry and Reactivity of Cys195
160. 2oip: Crystal Structure of The S290G Active Site Mutant of Ts- Dhfr from Cryptosporidium Hominis
161. 6auj: Crystal Structure of Thymidylate Synthase from Elizabethkingia Anophelis Nuhp1
162. 6aoi: Crystal Structure of Toxoplasma Gondii Ts-dhfr Complexed with Nadph, Dump, Pddf, and 5-(4-phenylpiperazin-1-yl)-6-propylpyrimidine-2,4- Diamine (trc-2528)
163. 6aoh: Crystal Structure of Toxoplasma Gondii Ts-dhfr Complexed with Nadph, Dump, Pddf, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1- Yl)pyrimidine-2,4-diamine (trc-2533)
164. 6aog: Crystal Structure of Toxoplasma Gondii Ts-dhfr Complexed with Nadph, Dump, Pddf, and 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine (pyrimethamine)
165. 2ftn: E. Coli Thymidylate Synthase Y94F Mutant
166. 2fto: Y94F Mutant of Thymidylate Synthase Bound to Thymidine-5'- Phosphate and 10-propargyl-5,8-dideazafolid Acid
167. 2ftq: E. Coli Thymidylate Synthase at 1.8 a Resolution
168. 2g86: L. Casei Thymidylate Synthase Y261F in Complex with Substrate, Dump
169. 2g89: L. Casei Thymidylate Synthase Y261A in Complex with Substrate, Dump
170. 2g8a: Lactobacillus Casei Y261M in Complex with Substrate, Dump
171. 2g8d: Lactobacillus Casei Thymidylate Synthase Y261W-DUMP Complex
172. 2g8x: Escherichia Coli Y209W Apoprotein
173. 2h2q: Crystal Structure of Trypanosoma Cruzi Dihydrofolate Reductase-thymidylate Synthase
174. 2kce: Binding of The Anticancer Drug Zd1694 to E. Coli Thymidylate Synthase: Assessing Specificity and Affinity
175. 6k7s: Crystal Structure of Thymidylate Synthase from Shrimp
176. 6k7r: Crystal Structure of Thymidylate Synthase from Shrimp
177. 6k7q: Crystal Structure of Thymidylate Synthase from Shrimp
178. 3ob7: Human Thymidylate Synthase R163K with Cys 195 Covalently Modified by Glutathione
179. 3n5e: Crystal Structure of Human Thymidylate Synthase Bound to a Peptide Inhibitor
180. 3n5g: Crystal Structure of Histidine-tagged Human Thymidylate Synthase
181. 3qg2: Plasmodium Falciparum Dhfr-ts Qradruple Mutant (N51I+C59R+S108N+I164L, V1/s) Pyrimethamine Complex
182. 3qgt: Crystal Structure of Wild-type Pfdhfr-ts Complexed with Nadph, Dump and Pyrimethamine
183. 3qj7: Crystal Structure of The Mycobacterium Tuberculosis Thymidylate Synthase (thya) Bound to Dump
184. 6r2e: Crystal Structure of The Human Thymidylate Synthase (hts) Interface Variant Q62R
185. 6qyq: Crystal Structure of Human Thymidylate Synthase (hts) Variant R175C
186. 6qya: Crystal Structure of Enteroccocus Faecalis Thymidylate Synthase (efts) in Complex with Dump
187. 6qxs: Crystal Structure of Enteroccocus Faecalis Thymidylate Synthase (efts) in Complex with Fdump
188. 6qxh: Crystal Structure of His-tag Human Thymidylate Synthase (ht-hts) in Complex with Dump
189. 6qxg: Crystal Structure of His-tag Human Thymidylate Synthase (ht-hts) in Complex with Fdump
190. 3v8h: Crystal Structure of Thymidylate Synthase from Burkholderia Thailandensis
191. 6pf6: Crystal Structure of Ts-dhfr from Cryptosporidium Hominis in Complex with Nadph, Fdump and 2-(4-((2-amino-4-oxo-4,7-dihydro-3h-pyrrolo[2, 3-d]pyrimidin-5-yl)methyl)benzamido)terephthalic Acid
192. 6pf5: Crystal Structure of Human Thymidylate Synthase Delta (7-29) in Complex with Dump and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3h- Pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-methoxyphenyl)acetic Acid
193. 6pf4: Crystal Structure of Human Thymidylate Synthase Delta (7-29) in Complex with Dump and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3h- Pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)phenyl)acetic Acid
194. 6pf3: Crystal Structure of Human Thymidylate Synthase Delta (7-29) in Complex with Dump and 2-(4-((2-amino-4-oxo-4,7-dihydro-3h-pyrrolo[2, 3-d]pyrimidin-5-yl)methyl)benzamido)-4-chlorobenzoic Acid
195. 6ojv: Crystal Structure of Human Thymidylate Synthase Delta(7-29) in Complex with Dump and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine- Methyl-phenyl-l-glutamic Acid
196. 6oju: Crystal Structure of Human Thymidylate Synthase Delta (7-29) in Complex with Dump and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3- D]pyrimidine-methyl-phenyl-d-glutamic Acid
197. 4dq1: Thymidylate Synthase from Staphylococcus Aureus.
198. 4e5o: Crystal Structure of Mouse Thymidylate Synthase in Complex with Dump
199. 6nnr: High-resolution Structure of Wild-type E. Coli Thymidylate Synthase
200. 4eb4: Crystal Structure of Mouse Thymidylate Synthase in Ternary Complex with Dump and Tomudex
201. 6n1t: Toxoplasma Gondii Ts-dhfr in Complex with Selective Inhibitor 3
202. 6n1s: Toxoplasma Gondii Ts-dhfr in Complex with Selective Inhibitor 29
203. 3um5: Double Mutant (A16V+S108T) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts-t9/94) Complexed with Pyrimethamine, Nadph, and Dump
204. 3um6: Double Mutant (A16V+S108T) Plasmodium Falciparum Dhfr-ts (t9/94) Complexed with Cycloguanil, Nadph and Dump
205. 3um8: Wild-type Plasmodium Falciparum Dhfr-ts Complexed with Cycloguanil and Nadph
206. 3uwl: Crystal Structure of Enteroccocus Faecalis Thymidylate Synthase (efts) in Complex with 5-formyl Tetrahydrofolate
207. 4gev: E. Coli Thymidylate Synthase Y209W Variant in Complex with Substrate and a Cofactor Analog
208. 4gyh: Structure of Human Thymidylate Synthase at High Salt Conditions
209. 4h1i: Structure of Human Thymidylate Synthase at Low Salt Conditions
210. 4dp3: Quadruple Mutant (N51I+C59R+S108N+I164L) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts) Complexed with P218 and Nadph
211. 4dph: Quadruple Mutant (N51I+C59R+S108N+I164L) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts) Complexed with P65 and Nadph
212. 4e28: Structure of Human Thymidylate Synthase in Inactive Conformation with a Novel Non-peptidic Inhibitor
213. 4ein: Crystal Structure of Mouse Thymidylate Synthase in Binary Complex with a Substrate Analogue and Strong Inhibitor, N(4)-hydroxy-2'- Deoxycytidine-5'-monophosphate
214. 6gyj: Mouse Thymidylate Synthase Crystal Soaked in Phenolphthalein
215. 4fgt: Allosteric Peptidic Inhibitor of Human Thymidylate Synthase That Stabilizes Inactive Conformation of The Enzyme.
216. 6gko: Mouse Thymidylate Synthase Cocrystallized with Dump and Soaked in Phenolphthalein
217. 4ez8: Crystal Structure of Mouse Thymidylate Sythase in Ternary Complex with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate and The Cofactor Product, Dihydrofolate
218. 6f6z: Mouse Thymidylate Synthase Cocrystallized with N(4)ohdcmp and Soaked in Methylenetetrahydrofolate
219. 4g2o: Human Thymidylate Synthase M190K with Bound Purpurogallin
220. 4g6w: Human Thymidylate Synthase M190K with Bound 4-bromobenzene-1,2,3-triol
221. 4gd7: Wild-type Human Thymidylate Synthase with Bound Purpurogallin
222. 4foa: Crystal Structure of The Mtb Thya in Complex with 5-fluoro-dump
223. 4fog: Crystal Structure of Mtb Thya in Complex with 5-fluoro-dump and 5- Methyltetrahydrofolic Acid
224. 4fox: Crystal Structure of Mtb Thya in Complex with Dump and Raltitrexed
225. 4fqs: Crystal Structure of Mycobacterium Tuberculosis Thya in Complex with Ump and Pemetrexed
226. 6cdz: E. Coli Thymidylate Synthase Mutant I264AM
227. 4eck: Crystal Structure of The Toxoplasma Gondii Ts-dhfr
228. 4eil: Crystal Structure of The Loop Truncated Toxoplasma Gondii Ts-dhfr
229. 4h0r: Crystal Structure of Thymidylate Synthase from Corynebacterium Glutamicum
230. 4h0u: Crystal Structure of Thymidylate Synthase from Corynebacterium Glutamicum in Complex with Dump
231. 4iqb: High Resolution Crystal Structure of C.elegans Thymidylate Synthase
232. 4iqq: Crystal Structure of C.elegans Thymidylate Synthase in Complex with Dump and Tomudex
233. 4irr: Crystal Structure of C.elegans Thymidylate Synthase in Complex with Dump
234. 4isk: Crystal Structure of E.coli Thymidylate Synthase with Dump and The Bgc 945 Inhibitor
235. 4isw: Crystal Structure of Phosphorylated C.elegans Thymidylate Synthase in Complex with Dump
236. 4jef: Crystal Structure of Human Thymidylate Synthase Y202A in Inactive Conformation.
237. 4kpw: Crystal Structure of His-tagged Human Thymidylate Synthase R175A Mutant
238. 4ky4: Crystal Structure of Non-classical Ts Inhibitor 2 in Complex with Toxoplasma Gondii Ts-dhfr
239. 4ky8: Crystal Structure of Ts-dhfr from Cryptosporidium Hominis in Complex with Nadph, Methotrexate, Fdump and 4-((2-amino-6-methyl-4-oxo-4,7- Dihydro-3h-pyrrolo[2,3-d]pyrimidin-5-yl)thio)-2-chlorophenyl)-l- Glutamic Acid
240. 4kya: Crystal Structure of Non-classical Ts Inhibitor 3 in Complex with Toxoplasma Gondii Ts-dhfr
241. 4lrr: Ternary Complex between E. Coli Thymidylate Synthase, Dump, and F9
242. 4q0d: Crystal Structure of Ts-dhfr from Cryptosporidium Hominis in Complex with Nadph, Fdump, Methotrexate and 2-amino-4-oxo-4,7-dihydro- Pyrrolo[2,3-d]pyrimidine-methyl-phenyl-l-glutamic Acid.
243. 4q0e: Crystal Structure of Ts-dhfr from Cryptosporidium Hominis in Complex with Nadph, Fdump and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3- D]pyrimidine-methyl-phenyl-l-glutamic Acid.
244. 5x69: Human Thymidylate Synthase with a Fragment Bound in The Dimer Interface
245. 5x67: Human Thymidylate Synthase in Complex with Dump and Nolatrexed
246. 5x66: Human Thymidylate Synthase in Complex with Dump and Methotrexate
247. 5x5q: Human Thymidylate Synthase Complexed with Dump and Raltitrexed
248. 5x5d: Human Thymidylate Synthase Bound with Dump
249. 5x5a: Human Thymidylate Synthase Bound with Phosphate Ion
250. 5x4y: Mutant Human Thymidylate Synthase M190K Crystallized in a Sulfate- Containing Condition
251. 5x4x: Mutant Human Thymidylate Synthase A191K Crystallized in a Sulfate- Containing Condition
252. 5x4w: Mutant Human Thymidylate Synthase A191K Crystallized in a Sulfate-free Condition
253. 5wrn: Human Thymidylate Synthase Complexed with Dcmp
254. 5t0l: Crystal Structure of Toxoplasma Gondii Ts-dhfr Complexed with Nadph, Dump, Pddf and 5-(4-(3,4-dichlorophenyl)piperazin-1-yl)pyrimidine-2, 4-diamine (trc-15)
255. 5noo: Crystal Structure of C.elegans Thymidylate Synthase in Complex with Dump and Tomudex
256. 5m4z: Crystal Structure of The Complex of T.spiralis Thymidylate Synthase with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate, Crystallized in The Presence of N(5,10)-methylenetetrahydrofolate
257. 5j7w: Enterococcus Faecalis Thymidylate Synthase Complex with Methotrexate
258. 5hs3: Human Thymidylate Synthase Complexed with Dump and 3-amino-2-benzoyl- 4-methylthieno[2,3-b]pyridin-6-ol
259. 5by6: Crystal Structure of Trichinella Spiralis Thymidylate Synthase Complexed with Dump
260. 4o1u: Crystal Structure of Human Thymidylate Synthase Mutant Y202C
261. 4o1x: Crystal Structure of Human Thymidylate Synthase Double Mutant C195S- Y202C
262. 4o7u: Etherocomplex of Enteroccocus Faecalis Thymidylate Synthase with 5- Hydroxymethilene-6-hydrofolic Acid and The Phtalimidic Inhibitor Ss7
263. 4psg: Crystal Structure of C.elegans Thymidylate Synthase in Complex with an Inhibitor N(4)ohdcmp
264. 4up1: Crystal Structure of Native Human Thymidylate Synthase in Active Form
265. 4xsc: Complex Structure of Thymidylate Synthase from Varicella Zoster Virus with a Phosphorylated Bvdu
266. 4xsd: Complex Structure of Thymidylate Synthase from Varicella Zoster Virus with a Dump
267. 4xse: Complex Structure of Thymidylate Synthase from Varicella Zoster Virus
268. 6y08: Mouse Thymidylate Synthase Cocrystallized with Dump and Soaked in Sulfamethoxazole
269. 7jx1: E. Coli Tsase Complex with a Bi-substrate Reaction Intermediate Analog
270. 7jxf: E. Coli Tsase Complex with a Bi-substrate Reaction Intermediate Diastereomer Analog
271. 6zxo: Crystal Structure of His-tagged Human Thymidylate Synthase (ht-hts) in Complex with Fdump and Raltitrexed (tomudex)
272. 7dp4: Crystal Structure of Wild Type Brugia Malayi Thymidylate Synthase Complexed with 2'-deoxyuridine Monophosphate and Methotrexate
273. 7dp5: Crystal Structure of Mutant V45A Brugia Malayi Thymidylate Synthase Complexed with 2'-deoxyuridine Monophosphate and Methotrexate
274. 7dp6: Crystal Structure of Mutant V45T Brugia Malayi Thymidylate Synthase Complexed with 2'-deoxyuridine Monophosphate