Enzyme classes: General information:
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EC 2.7.12.1 - ATP:protein phosphotransferase (Ser/Thr- and Tyr- phosphorylating) (dual- specificity kinase)
3D structures of EC 2.7.12.1 - dual-specificity kinase in Protein Data Bank
updated: 6 January 2022, 2:15
In total: 234 PDB structures of EC 2.7.12.1 - dual-specificity kinase:
- 3nr9: Structure of Human Cdc2-like Kinase 2 (clk2)
- 3kvw: Crystal Structure of Dual-specificity Tyrosine Phosphorylation Regulated Kinase 2 (dyrk2) in Complex with an Indirubin Ligand
- 3k2l: Crystal Structure of Dual-specificity Tyrosine Phosphorylation Regulated Kinase 2 (dyrk2)
- 3hmp: Crystal Structure of Human Mps1 Catalytic Domain in Complex with a Quinazolin Ligand Compound 4
- 3hmo: Crystal Structure of Human Mps1 Catalytic Domain in Complex with The Inhibitor Staurosporine
- 3hmn: Crystal Structure of Human Mps1 Catalytic Domain in Complex with Atp
- 3h9f: Crystal Structure of Human Dual Specificity Protein Kinase (ttk) in Complex with a Pyrimido-diazepin Ligand
- 3gfw: Crystal Structure of Human Dual Specificity Protein Kinase (ttk) in Complex with a Pyrolo-pyridin Ligand
- 3dbq: Crystal Structure of Ttk Kinase Domain
- 3cek: Crystal Structure of Human Dual Specificity Protein Kinase (ttk)
- 6uwy: DYRK1A Bound to a Harmine Derivative
- 3anr: Human DYRK1A/HARMINE Complex
- 3anq: Human DYRK1A/INHIBITOR Complex
- 2zmd: Crystal Structure of Human Mps1 Catalytic Domain T686A Mutant in Complex with Sp600125 Inhibitor
- 2zmc: Crystal Structure of Human Mitotic Checkpoint Kinase Mps1 Catalytic Domain Apo Form
- 2wu7: Crystal Structure of The Human Clk3 in Complex with V25
- 2wu6: Crystal Structure of The Human Clk3 in Complex with Dki
- 2wo6: Human Dual-specificity Tyrosine-phosphorylation-regulated Kinase 1a in Complex with a Consensus Substrate Peptide
- 1z57: Crystal Structure of Human Clk1 in Complex with 10z- Hymenialdisine
- 2vx3: Crystal Structure of The Human Dual Specificity Tyrosine- Phosphorylation-regulated Kinase 1a
- 2vag: Crystal Structure of Di-phosphorylated Human Clk1 in Complex with a Novel Substituted Indole Inhibitor
- 6ln1: A Natural Inhibitor of DYRK1A for Treatment of Diabetes Mellitus
- 7ak3: Clk1 Bound with Caf052
- 6zln: Clk1 Bound with GW807982X (cpd 8)
- 6z2v: Clk3 A319V Mutant Bound with Beta-carboline Kh-carb13 (cpd 3)
- 6yu1: Clk3 Bound with Beta-carboline Kh-carb13 (cpd 3)
- 6yty: Clk3 A319V Mutant Bound with Benzothiazole Tg003 (cpd 2)
- 6ytw: Clk3 Bound with Benzothiazole Tg003 (cpd 2)
- 6yti: Clk1 Bound with Eth1610 (cpd 17)
- 6ytg: Clk1 Bound with Beta-carboline Kh-carb13 (cpd 3)
- 6yte: Clk1 Bound with Benzothiazole Tg003 (cpd 2)
- 6ytd: Clk1 V324A Mutant Bound with Benzothiazole Tg003 (cpd 2)
- 6yta: Clk1 Bound with Imidazopyridazine (cpd 1)
- 6b4w: Ttk in Complex with Inhibitor
- 6a1g: Crystal Structure of Human DYRK1A in Complex with Compound 32
- 6a1f: Crystal Structure of Human DYRK1A in Complex with Compound 14
- 5ztn: The Crystal Structure of Human Dyrk2 in Complex with Curcumin
- 2eu9: Crystal Structure of Clk3
- 2x9e: Human Mps1 in Complex with Nms-p715
- 6z55: Crystal Structure of Clk3 in Complex with Macrocycle Ods2004070
- 6z54: Crystal Structure of Clk3 in Complex with Macrocycle Ods2003178
- 6z53: Crystal Structure of Clk3 in Complex with Macrocycle Ods2003128
- 6z52: Crystal Structure of Clk3 in Complex with Macrocycle Ods2003136
- 6z51: Crystal Structure of Clk3 in Complex with Macrocycle Ods2002941
- 6z50: Crystal Structure of Clk1 in Complex with Macrocycle Ods2003208
- 6z4z: Crystal Structure of Clk1 in Complex with Macrocycle Ods2004070
- 6tnd: X-ray Structure of Mps1 in Complex with Compound 79
- 6tnc: X-ray Structure of Mps1 in Complex with Compound 46
- 6tnb: X-ray Structure of Mps1 in Complex with Compound 41
- 6tn9: X-ray Structure of Mps1 in Complex with Compound 16
- 6r8j: Crystal Structure of Di-phosphorylated Human Clk1 in Complex with 4- (1-methyl-1h-indol-3-yl)pyrimidin-2-amine
- 6r6x: Crystal Structure of Di-phosphorylated Human Clk1 in Complex with 5- (1-methyl-1h-indol-3-yl)pyrimidin-4-amine
- 6r6e: Crystal Structure of Di-phosphorylated Human Clk1 in Complex with 5- (6,7-dichloro-1-methyl-1h-indol-3-yl)pyrimidin-4-amine
- 3raw: Crystal Structure of Human Cdc-like Kinase 3 Isoform in Complex with Leucettine L41
- 6r3d: Crystal Structure of Di-phosphorylated Human Clk1 in Complex with 4- (6,7-dichloro-1h-indol-3-yl)pyrimidin-2-amine
- 6qu2: Crystal Structure of DYRK1A Complexed with Fc162 Inhibitor
- 6qty: Non-phosphorylated Human Clk1 in Complex with an Indole Inhibitor to 1.65 Ang
- 6t6a: Crystal Structure of DYRK1A Complexed with Kufal319 (compound 11)
- 6s1j: Crystal Structure of DYRK1A with Small Molecule Inhibitor
- 6s1i: Crystal Structure of DYRK1A with Small Molecule Inhibitor
- 6s1h: Crystal Structure of DYRK1A with Small Molecule Inhibitor
- 6s1b: Crystal Structure of DYRK1A with Small Molecule Inhibitor
- 6s17: Crystal Structure of DYRK1A with Small Molecule Inhibitor
- 6s14: Crystal Structure of DYRK1A with Small Molecule Inhibitor
- 6s11: Crystal Structure of DYRK1A with Small Molecule Inhibitor
- 6rct: Crystal Structure of Clk3 in Complex with T3-clk
- 6raa: Clk1 Kinase Domain with Bound Imidazopyridin Inhibitor Tp003
- 6q8p: Structure of Clk1 with Bound N-methyl-10-nitropyrido[3,4-g]quinazolin- 2-amine
- 6q8k: Clk1 with Bound Pyridoquinazoline
- 6n6o: Crystal Structure of The Human Ttk in Complex with an Inhibitor
- 3vqu: Crystal Structure of Human Mps1 Catalytic Domain in Complex with 4- [(4-amino-5-cyano-6-ethoxypyridin-2- Yl)amino]benzamide
- 6uip: DYRK1A Kinase Domain in Complex with a 6-azaindole Derivative, Gnf2133.
- 6khf: Crystal Structure of Clk3 in Complex with Cx-4945
- 6khe: Crystal Structure of Clk2 in Complex with Cx-4945
- 6khd: Crystal Structure of Clk1 in Complex with Cx-4945
- 6k0j: The Co-crystal Structure of Dyrk2 with a Small Molecule Inhibitor
- 4aze: Human DYRK1A in Complex with Leucettine L41
- 6i5l: Crystal Structure of Clk1 in Complexed with Furo[3,2-b]pyridine Compound Vn316 (derivative of Compound 12h)
- 6i5k: Crystal Structure of Clk1 in Complexed with Furo[3,2-b]pyridine Compound Vn345 (derivative of Compound 12h)
- 6i5i: Crystal Structure of Clk1 in Complexed with Furo[3,2-b]pyridine Compound 12h
- 6i5h: Crystal Structure of Clk1 in Complex with Furanopyrimidin Vn412
- 4h7x: Crystal Structure of The Tetratricopeptide Repeat (tpr) Motif of Human Dual Specificity Protein Kinase Mps1
- 4h7y: Crystal Structure of The Tetratricopeptide Repeat (tpr) Motif of Human Dual Specificity Protein Kinase Mps1
- 6hdr: Human Dyrk2 Bound to Curcumin
- 6hdp: Human Dyrk2 Bound to Scorzodihydrostilbene a
- 6h3k: Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- D]pyrimidine Mps1 Inhibitors and Enables The Discovery of The Phase 1 Clinical Candidate Bos172722.
- 6gvj: Human Mps1 Kinase Domain with Ordered Activation Loop
- 4b94: Crystal Structure of Human Mps1 Tpr Domain
- 6g33: Crystal Structure of Clk1 in Complex with 5-iodotubercidin
- 4bhz: Scaffold Focused Virtual Screening: Prospective Application to The Discovery of Ttk Inhibitor
- 4bi0: Scaffold Focused Virtual Screening: Prospective Application to The Discovery of Ttk Inhibitor
- 4bi1: Scaffold Focused Virtual Screening: Prospective Application to The Discovery of Ttk Inhibitor
- 4bi2: Scaffold Focused Virtual Screening: Prospective Application to The Discovery of Ttk Inhibitor
- 6fyv: X-ray Structure of Clk4-kd(146-480)/cx-4945 at 2.46a
- 6fyr: X-ray Structure of Clk3-kd(gp-[275-632], Non-phos.)/cpd-2 at 1.42a
- 6fyp: X-ray Structure of Clk3-kd(gp-[275-632], Non-phos.)/cx-4945 at 2.29a
- 6fyo: X-ray Structure of Clk1-kd(148-484)/cpd-2 at 2.32a
- 6fyl: X-ray Structure of Clk2-kd(136-496)/cx-4945 at 1.95a
- 6fyk: X-ray Structure of Clk2-kd(136-496)/indazole1 at 2.39a
- 6fyi: X-ray Structure of Clk2-kd(130-496)/tg003 at 2.6a
- 6ft9: Crystal Structure of Clk1 in Complex with Inhibitor 16
- 6ft8: Crystal Structure of Clk1 in Complex with Inhibitor 8g
- 6ft7: Crystal Structure of Clk3 in Complex with Compound 8a
- 3w1f: Crystal Structure of Human Mps1 Catalytic Domain in Complex with 5-(5- Ethoxy-6-(1-methyl-1h-pyrazol-4-yl)-1h-indazol-3-yl)-2- Methylbenzenesulfonamide
- 6ej4: DYRK1A in Complex with Xmd7-112
- 6eiv: DYRK1A in Complex with Jwd-065
- 6eis: DYRK1A in Complex with Jwc-055
- 6eir: DYRK1A in Complex with Xmd15-27-2
- 6eiq: DYRK1A in Complex with Xmd14-124
- 6eip: DYRK1A in Complex with Xmd8-62e
- 6eij: DYRK1A in Complex with Hg-8-60-1
- 6eif: DYRK1A in Complex with Xmd7-117
- 6tw2: Re-refined Crystal Structure of Di-phosphorylated Human Clk1 in Complex with a Novel Substituted Indole Inhibitor
- 4c4e: Structure-based Design of Orally Bioavailable Pyrrolopyridine Inhibitors of The Mitotic Kinase Mps1
- 4c4f: Structure-based Design of Orally Bioavailable Pyrrolopyridine Inhibitors of The Mitotic Kinase Mps1
- 4c4g: Structure-based Design of Orally Bioavailable Pyrrolopyridine Inhibitors of The Mitotic Kinase Mps1
- 4c4h: Structure-based Design of Orally Bioavailable Pyrrolopyridine Inhibitors of The Mitotic Kinase Mps1
- 4c4i: Structure-based Design of Orally Bioavailable Pyrrolopyridine Inhibitors of The Mitotic Kinase Mps1
- 4c4j: Structure-based Design of Orally Bioavailable Pyrrolopyridine Inhibitors of The Mitotic Kinase Mps1
- 4js8: Crystal Structure of Ttk Kinase Domain with an Inhibitor: 401348
- 4jt3: Crystal Structure of Ttk Kinase Domain with an Inhibitor: 400740
- 4mq1: The Crystal Structure of DYRK1A with a Bound Pyrido[2,3-d]pyrimidine Inhibitor
- 4mq2: The Crystal Structure of DYRK1A with a Bound Pyrido[2,3-d]pyrimidine Inhibitor
- 5y86: Crystal Structure of Kinase
- 4pdp: Crystal Structure of Rad53 Kinase Domain and Scd2
- 4pds: Crystal Structure of Rad53 Kinase Domain and Scd2 in Complex with Amppnp
- 5xzw: Crystal Structure of Rad53 1-466
- 5xzv: Crystal Structure of Rad53 1-466 in Complex with Amp-pnp
- 5x8i: Crystal Structure of Human Clk1 in Complex with Compound 25
- 5unp: Structure of Cdc2-like Kinase 2 (clk2) in Complex with Compound T-025 [n2-methyl-n4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7h-pyrrolo[2, 3-d]pyrimidine-2,4-diamine]
- 5t2s: Structure of The Fha1 Domain of Rad53 Bound Simultaneously to The Brct Domain of Dbf4 and a Phosphopeptide.
- 5t2f: Structure of The Fha1 Domain of Rad53 Bound to The Brct Domain of Dbf4
- 5o91: Crystal Structure of Human Mps1 (ttk) C604W Mutant in Complex with Cpd-5
- 5ntt: Crystal Structure of Human Mps1 (ttk) C604Y Mutant in Complex with Nms-p715
- 5nad: Ttk Kinase Domain in Complex with Bay 1217389
- 5na0: Ttk Kinase Domain in Complex with a Peg-linked Pyrimido-indolizine
- 5n9s: Ttk Kinase Domain in Complex with Bay 1161909
- 5n93: Ttk Kinase Domain in Complex with Tc-mps1-12
- 5n87: Ttk Kinase Domain in Complex with Ntrc 0066-0
- 5n84: Ttk Kinase Domain in Complex with MPS-BAY2B
- 5n7v: Ttk Kinase Domain in Complex with Mpi-0479605
- 5mrb: Crystal Structure of Human Mps1 (ttk) in Complex with Cpd-5
- 5lxd: Crystal Structure of Dyrk2 in Complex with Eht 1610 (compound 2)
- 5lxc: Crystal Structure of Dyrk2 in Complex with Eht 5372 (compound 1)
- 5ljj: Crystal Structure of Human Mps1 (ttk) in Complex with Reversine
- 5j1w: Crystal Structure of Human Clk1 in Complex with Pyrido[3,4- G]quinazoline Derivative Zw31 (compound 14)
- 5j1v: Crystal Structure of Human Clk1 in Complex with Pyrido[3,4- G]quinazoline Derivative Zw29 (compound 13)
- 5ei8: Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (mps1) Using a Structure-based Hydridization Approach
- 5ei6: Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (mps1) Using a Structure-based Hydridization Approach
- 5ei2: Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (mps1) Using a Structure-based Hydridization Approach
- 5ehy: Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (mps1) Using a Structure-based Hydridization Approach
- 5eho: Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (mps1) Using a Structure-based Hydridization Approach
- 5ehl: Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (mps1) Using a Structure-based Hydridization Approach
- 5eh0: Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (mps1) Using a Structure-based Hydridization Approach
- 4o6l: Crystal Structure of Ttk Kinase Domain with an Inhibitor: 401498 (n- [(1r)-1-(2-chlorophenyl)propyl]-3-{4-[(1-methylpiperidin-4-yl) Oxy]phenyl}-1h-indazole-5-carboxamide)
- 3wzj: Crystal Structure of Human Mps1 Catalytic Domain in Complex with 4-(6- (cyclohexylamino)-8-(((tetrahydro-2h-pyran-4-yl)methyl)amino) Imidazo[1,2-b]pyridazin-3-yl)-n-cyclopropylbenzamide
- 3wzk: Crystal Structure of Human Mps1 Catalytic Domain in Complex with N- Cyclopropyl-4-(8-((thiophen-2-ylmethyl)amino)imidazo[1,2-a]pyrazin-3- Yl)benzamide
- 5ap7: Naturally Occurring Mutations in The Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
- 5ap6: Naturally Occurring Mutations in The Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
- 5ap5: Naturally Occurring Mutations in The Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
- 5ap4: Naturally Occurring Mutations in The Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
- 5ap3: Naturally Occurring Mutations in The Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
- 5ap2: Naturally Occurring Mutations in The Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
- 5ap1: Naturally Occurring Mutations in The Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
- 5ap0: Naturally Occurring Mutations in The Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
- 5a54: DYRK1A in Complex with Nitro Benzothiazole Fragment
- 5a4t: DYRK1A in Complex with Nitrile Benzothiazole Fragment
- 5a4q: DYRK1A in Complex with Chloro Benzothiazole Fragment
- 5a4l: DYRK1A in Complex with Fluoro Benzothiazole Fragment
- 5a4e: DYRK1A in Complex with Methoxy Benzothiazole Fragment
- 5a3x: DYRK1A in Complex with Hydroxy Benzothiazole Fragment
- 4zeg: Crystal Structure of Ttk Kinase Domain in Complex with a Pyrazolopyrimidine Inhibitor
- 4ylj: Crystal Structure of DYRK1A in Complex with 10-iodo-substituted 11h- Indolo[3,2-c]quinoline-6-carboxylic Acid Inhibitor 5j
- 4ylk: Crystal Structure of DYRK1A in Complex with 10-chloro-substituted 11h- Indolo[3,2-c]quinolone-6-carboxylic Acid Inhibitor 5s
- 4yll: Crystal Structure of DYRK1AA in Complex with 10-bromo-substituted 11h- Indolo[3,2-c]quinolone-6-carboxylic Acid Inhibitor 5t
- 4yu2: Crystal Structure of DYRK1A with Harmine-derivatized Annh-75 Inhibitor
- 4nct: Human DYRK1A in Complex with Pkc412
- 3wyx: Crystal Structure of Human Mps1 Catalytic Domain in Complex with 6- ((3-(cyanomethoxy)-4-(1-methyl-1h-pyrazol-4-yl)phenyl)amino)-2- (cyclohexylamino)nicotinonitrile
- 3wyy: Crystal Structure of Human Mps1 Catalytic Domain in Complex with (e)- 3-(4-((6-(((3s,5s,7s)-adamantan-1-yl)amino)-4-amino-5-cyanopyridin-2- Yl)amino)-2-(cyanomethoxy)phenyl)-n-(2-methoxyethyl)acrylamide
- 4cv8: Mps1 Kinase with 3-aminopyridin-2-one Inhibitors
- 4cv9: Mps1 Kinase with 3-aminopyridin-2-one Inhibitors
- 4cva: Mps1 Kinase with 3-aminopyridin-2-one Inhibitors
- 4d2s: Human Ttk in Complex with a DYRK1B Inhibitor
- 6yf8: DYRK1A with Pst001
- 7chm: Crystal Structure of Ttk Kinase Domain in Complex with Compound 8
- 7chn: Crystal Structure of Ttk Kinase Domain in Complex with Compound 9
- 7cht: Crystal Structure of Ttk Kinase Domain in Complex with Compound 30
- 7cil: Crystal Structure of Ttk Kinase Domain in Complex with Compound 7
- 7cja: Crystal Structure of Ttk Kinase Domain in Complex with Compound 28
- 7clh: Crystal Structure of Ttk Kinase Domain in Complex with Compound 19
- 7aj2: Structure of DYRK1A in Complex with Compound 3
- 7aj4: Structure of DYRK1A in Complex with Compound 5
- 7aj5: Structure of DYRK1A in Complex with Compound 10
- 7aj7: Structure of DYRK1A in Complex with Compound 16
- 7aj8: Structure of DYRK1A in Complex with Compound 25
- 7aja: Structure of DYRK1A in Complex with Compound 28
- 7ajm: Structure of DYRK1A in Complex with Compound 32
- 7ajs: Structure of DYRK1A in Complex with Compound 33
- 7ajv: Structure of DYRK1A in Complex with Compound 38
- 7ajw: Structure of DYRK1A in Complex with Compound 46
- 7ajy: Structure of DYRK1A in Complex with Compound 51
- 7ak2: Structure of DYRK1A in Complex with Compound 53
- 7aka: Structure of DYRK1A in Complex with Compound 54
- 7akb: Structure of DYRK1A in Complex with Compound 56
- 7ake: Structure of DYRK1A in Complex with Compound 58
- 7akf: Structure of Dyrk2 in Complex with Compound 50
- 7akh: Structure of Dyrk2 in Complex with Compound 58
- 7akl: Structure of DYRK1A in Complex with Compound 50
- 7a4o: Structure of DYRK1A in Complex with Ampnp
- 7a4r: Structure of DYRK1A in Complex with Compound 1
- 7a4s: Structure of DYRK1A in Complex with Compound 2
- 7a4w: Structure of DYRK1A in Complex with Compound 3
- 7a4z: Structure of DYRK1A in Complex with Compound 4
- 7a51: Structure of DYRK1A in Complex with Compound 5
- 7a52: Structure of DYRK1A in Complex with Compound 6
- 7a53: Structure of DYRK1A in Complex with Compound 7
- 7a55: Structure of DYRK1A in Complex with Compound 8
- 7a5b: Structure of DYRK1A in Complex with Complex 10
- 7a5d: Structure of DYRK1A in Complex with Compound 16
- 7a5l: Tructure of DYRK1A in Complex with Compound 24
- 7a5n: Structure of DYRK1A in Complex with Compound 34
- 7opg: Crystal Structure of Clk1 in Complex with Compound 2 (cc513)
- 7dg4: The Co-crystal Structure of Dyrk2 with a Small Molecule Inhibitor 6
- 7dh3: The Co-crystal Structure of Dyrk2 with a Small Molecule Inhibitor 5
- 7dh9: The Co-crystal Structure of Dyrk2 with a Small Molecule Inhibitor 7
- 7dhc: The Co-crystal Structure of Dyrk2 with a Small Molecule Inhibitor 10
- 7dhh: The Co-crystal Structure of Dyrk2 with a Small Molecule Inhibitor 19
- 7dhk: The Co-crystal Structure of Dyrk2 with a Small Molecule Inhibitor 13
- 7dhn: The Co-crystal Structure of Dyrk2 with a Small Molecule Inhibitor 20
- 7dho: The Co-crystal Structure of Dyrk2 with a Small Molecule Inhibitor 14
- 7dhv: The Co-crystal Structure of Dyrk2 with a Small Molecule Inhibitor 8
- 7djo: The Co-crystal Structure of Dyrk2 with a Small Molecule Inhibitor 17
- 7o7k: Crystal Structure of The Human DYRK1A Kinase Domain Bound to Abemaciclib
- 7dl6: The Co-crystal Structure of Dyrk2 with a Small Molecule Inhibitor 18
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