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enzyme (lysozyme)

 
Enzymes
  Enzyme classes:
  EC 1: Oxidoreductases
  EC 2: Transferases
    EC 2.1
    EC 2.2
    EC 2.3
    EC 2.4
    EC 2.5
    EC 2.6
    EC 2.7
      EC 2.7.1
      EC 2.7.2
      EC 2.7.3
      EC 2.7.4
      EC 2.7.5
      EC 2.7.6
      EC 2.7.7
      EC 2.7.8
      EC 2.7.9
      EC 2.7.10
      EC 2.7.11
      EC 2.7.12
        EC 2.7.12.1
        EC 2.7.12.2
      EC 2.7.13
      EC 2.7.14
    EC 2.8
    EC 2.9
  EC 3: Hydrolases
  EC 4: Lyases
  EC 5: Isomerases
  EC 6: Ligases
  General information:
  Catalytic mechanism
  Enzyme kinetics
  Inhibitors
  Enzymes in industry

EC 2.7.12.2 - ATP:protein phosphotransferase (MAPKKK- activated) (mitogen- activated protein kinase kinase)



3D structures of EC 2.7.12.2 - mitogen-activated protein kinase kinase in Protein Data Bank

updated: 6 January 2022, 2:15

In total: 117 PDB structures of EC 2.7.12.2 - mitogen-activated protein kinase kinase:
  1. 3mbl: Crystal Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek 1) in Complex with Ligand and Mgadp
  2. 3fme: Crystal Structure of Human Mitogen-activated Protein Kinase Kinase 6 (mek6) Activated Mutant (S207D, T211D)
  3. 3eqi: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Binary Complex with Adp and MG2P
  4. 3eqh: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Ternary Complex with U0126, Adp and MG2P
  5. 3eqg: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Ternary Complex with Pd, Adp and MG2P
  6. 3eqf: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Binary Complex with K252A and MG2P
  7. 3eqd: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Binary Complex with Atp-gs and MG2P
  8. 3eqc: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Ternary Complex with Compound 1, Atp-gs and MG2P
  9. 3eqb: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Complex with Ligand and Mgatp
  10. 3enm: The Structure of The MAP2K Mek6 Reveals an Autoinhibitory Dimer
  11. 3e8n: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) Complexed with a Potent Inhibitor Rdea119 and Mgatp
  12. 3dy7: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Complex with Ligand and Mgatp
  13. 3dv3: Mek1 with Pf-04622664 Bound
  14. 3alo: Crystal Structure of Human Non-phosphorylated Mkk4 Kinase Domain Ternary Complex with Amp-pnp and P38 Peptide
  15. 3aln: Crystal Structure of Human Non-phosphorylated Mkk4 Kinase Domain Complexed with Amp-pnp
  16. 2vkn: Yeast Sho1 Sh3 Domain Complexed with a Peptide from Pbs2
  17. 7jv1: Crystal Structure of Ksr1:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Aps-9-95-1
  18. 7jv0: Crystal Structure of Ksr1:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Pd0325901
  19. 7juz: Crystal Structure of Ksr1:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Selumetinib
  20. 7juy: Crystal Structure of Ksr1:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Cobimetinib
  21. 7jux: Crystal Structure of Ksr1:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Trametinib
  22. 7juw: Crystal Structure of Ksr1:mek1 in Complex with Amp-pnp
  23. 7juv: Crystal Structure of Ksr2:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Aps-9-95-1
  24. 7juu: Crystal Structure of Ksr2:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Pd0325901
  25. 7jut: Crystal Structure of Ksr2:mek1 in Complex with Anp-pnp, and Allosteric Mek Inhibitor Selumetinib
  26. 7jus: Crystal Structure of Ksr2:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Cobimetinib
  27. 7jur: Crystal Structure of Ksr2:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Trametinib
  28. 7juq: Crystal Structure of Ksr2:mek1 in Complex with Adp
  29. 7cbx: Crystal Structure of MAP2K7 Complexed with a Covalent Inhibitor 12
  30. 2p55: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Complex with Ligand and Mgatp
  31. 6yz4: Crystal Structure of Mkk7 (MAP2K7) with Ibrutinib Bound at Allosteric Site
  32. 6yg7: Crystal Structure of Mkk7 (MAP2K7) Covalently Bound with Type-ii Inhibitor Sb1-g-23
  33. 6yg6: Crystal Structure of Mkk7 (MAP2K7) Covalently Bound with Type-ii Inhibitor Tl10-105
  34. 6yg5: Crystal Structure of Mkk7 (MAP2K7) in Complex with Asc69
  35. 6yg4: Crystal Structure of Mkk7 (MAP2K7) in Complex with K00007
  36. 6yg3: Crystal Structure of Mkk7 (MAP2K7) Covalently Bound with Cpt1-70-1
  37. 6yg2: Crystal Structure of Mkk7 (MAP2K7) in Complex with Ibrutnib, with Covalent and Allosteric Binding Modes
  38. 6yg1: Crystal Structure of Mkk7 (MAP2K7) in an Active State, Allosterically Triggered by The N-terminal Helix
  39. 6yg0: Crystal Structure of S287D,T291D Mkk7 (MAP2K7), Apo Form
  40. 6yfz: Crystal Structure of Mkk7 (MAP2K7), Apo Form
  41. 2dyl: Crystal Structure of Human Mitogen-activated Protein Kinase Kinase 7 Activated Mutant (S287D, T291D)
  42. 2o2v: Crystal Structure of The Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-PHOX) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-PHOX)
  43. 2npt: Crystal Structure of The Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-PHOX) with Human Mitogen Activated Protein Kinase Kinase Kinase 2 Phox Domain (MAP3K2-PHOX)
  44. 5z1e: MAP2K7 C218S Mutant-inhibitor
  45. 5z1d: MAP2K7 C276S Mutant-inhibitor
  46. 6x2x: Crystal Structure of MEK1NES Peptide Bound to CRM1(E571K)
  47. 6x2s: Crystal Structure of Mek1(nq)nes Peptide Bound to Crm
  48. 6x2p: Crystal Structure of The MEK1NES Peptide Bound to Crm1
  49. 6v2w: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp
  50. 2y4i: Ksr2-mek1 Heterodimer
  51. 3orn: Mitogen-activated Protein Kinase Kinase 1 (mek1) in Complex with Ch4987655 and Mgamp-pnp
  52. 3pp1: Crystal Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek 1) in Complex with Ligand and Mgatp
  53. 3os3: Mitogen-activated Protein Kinase Kinase 1 (mek1) in Complex with Ch4858061 and Mgatp
  54. 6u2g: Braf-mek Complex with Amp-pcp Bound to Braf
  55. 6qhr: Structure of The Mitogen Activated Kinase Kinase 7 in Complex with Pyrazolopyrimidine 1m
  56. 6qho: Dual Specificity Mitogen-activated Protein Kinase Kinase 7 in Complex with Pyrazolopyrimidine 1a
  57. 6qg7: Structure of The Mitogen Activated Kinase Kinase 7 in Complex with Pyrazolopyrimidine 1k
  58. 6qg4: Structure of The Mitogen Activated Kinase Kinase 7 in Complex with Pyrazolopyrimidine Inhibitor 1h
  59. 6qft: Structure of The Mitogen Activated Kinase Kinase 7 in Complex with Pyrazolopyrimidin 1b
  60. 6qfr: Structure of The Mitogen Activated Kinase Kinase 7 Dfg-out Conformation
  61. 6qfl: Structure of The Mitogen Activated Kinase Kinase 7 Active Conformation
  62. 6q0t: Structure of a Mapk Pathway Complex
  63. 6q0j: Structure of a Mapk Pathway Complex
  64. 6pp9: Crystal Structure of Braf:mek1 Complex
  65. 2y8o: Crystal Structure of Human P38ALPHA Complexed with a Mapk Docking Peptide
  66. 3sls: Crystal Structure of Human Mek-1 Kinase in Complex with Ucb1353770 and Amppnp
  67. 3vn9: Rifined Crystal Structure of Non-phosphorylated MAP2K6 in a Putative Auto-inhibition State
  68. 6nyb: Structure of a Mapk Pathway Complex
  69. 3v01: Discovery of Novel Allosteric Mek Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions.
  70. 3v04: Discovery of Novel Allosteric Mek Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions.
  71. 3vut: Crystal Structures of Non-phosphorylated MAP2K4
  72. 6ib2: The Structure of Mkk7 in Complex with The Covalent 4-amino- Pyrazolopyrimidine 4a
  73. 6ib0: The Structure of Mkk7 in Complex with The Covalent 4-amino- Pyrazolopyrimidine 3a
  74. 4an2: Crystal Structures of Human Mek1 with Carboxamide-based Allosteric Inhibitor Xl518 (gdc-0973), or Related Analogs.
  75. 4an3: Crystal Structures of Human Mek1 with Carboxamide-based Allosteric Inhibitor Xl518 (gdc-0973), or Related Analogs.
  76. 4an9: Crystal Structures of Human Mek1 with Carboxamide-based Allosteric Inhibitor Xl518 (gdc-0973), or Related Analogs.
  77. 4anb: Crystal Structures of Human Mek1 with Carboxamide-based Allosteric Inhibitor Xl518 (gdc-0973), or Related Analogs.
  78. 4h3q: Crystal Structure of Human Erk2 Complexed with a Mapk Docking Peptide
  79. 4ic7: Crystal Structure of The Erk5 Kinase Domain in Complex with an Mkk5 Binding Fragment
  80. 4ark: Crystal Structure of The Catalytic Domain of Human Map Kinase Kinase 1 (mek1) in Complex with a Small Molecule Inhibitor and Adp
  81. 3zls: Crystal Structure of Mek1 in Complex with Fragment 6
  82. 3zlw: Crystal Structure of Mek1 in Complex with Fragment 3
  83. 3zlx: Crystal Structure of Mek1 in Complex with Fragment 18
  84. 3zly: Crystal Structure of Mek1 in Complex with Fragment 8
  85. 3zm4: Crystal Structure of Mek1 in Complex with Fragment 1
  86. 4bf2: Crystal Structures of Ask1-inhibitor Complexes
  87. 4lmn: Crystal Structure of Mek1 Kinase Bound to Gdc0973
  88. 3vvh: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in Complex with an Inhibitor and Mgatp
  89. 3w8q: Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1)
  90. 3wig: Human Mek1 Kinase in Complex with Ch5126766 and Mgamp-pnp
  91. 4mne: Crystal Structure of The Braf:mek1 Complex
  92. 5y90: MAP2K7 Mutant -C218S
  93. 5y8u: Crystal Structure of The C276S Mutant of MAP2K7
  94. 4u7z: Mitogen-activated Protein Kinase Kinase (mek1) Bound to G805
  95. 4u80: Mek 1 Kinase Bound to G799
  96. 4u81: Mek1 Kinase Bound to Small Molecule Inhibitor G659
  97. 5kkr: Ksr2:mek1 Complex Bound to The Small Molecule Aps-2-79
  98. 5j0a: Crystal Structure of Pdz-binding Kinase
  99. 5hze: Mek1 Adopts Dfg-out Conformation When Bound to an Analog of E6201.
  100. 5eym: Mek1 in Complex with Bi 847325
  101. 5etf: Structure of Dead Kinase Mapk14 with Bound The Kim Domain of Mkk6
  102. 5bx0: An Automated Microscale Thermophoresis Screening Approach for Fragment-based Lead Discovery
  103. 3wzu: The Structure of MAP2K7 in Complex with 5z-7-oxozeaenol
  104. 5b2m: A Crucial Role of Cys218 in The Stabilization of an Unprecedented Auto-inhibition Form of MAP2K7
  105. 5b2l: A Crucial Role of Cys218 in The Stabilization of an Unprecedented Auto-inhibition Form of MAP2K7
  106. 5b2k: A Crucial Role of Cys218 in The Stabilization of an Unprecedented Auto-inhibition Form of MAP2K7
  107. 7b3m: Mek1 in Complex with Compound 6
  108. 7b7r: Mek1 in Complex with Compound 4
  109. 7b94: Mek1 in Complex with Compound 6
  110. 7b9l: Mek1 in Complex with Compound 23
  111. 7m0t: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp and Selumetinib
  112. 7m0u: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp and Binimetinib
  113. 7m0v: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp and Cobimetinib
  114. 7m0w: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp and Pimasertib
  115. 7m0x: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp and Pd0325901
  116. 7m0y: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp and Trametinib
  117. 7m0z: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp and Ch5126766
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