EC 2.7.12.2 - ATP:protein phosphotransferase (MAPKKK- activated) (mitogen- activated protein kinase kinase)

3D structures of EC 2.7.12.2 - mitogen-activated protein kinase kinase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 3mbl: Crystal Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek 1) in Complex with Ligand and Mgadp
2. 3fme: Crystal Structure of Human Mitogen-activated Protein Kinase Kinase 6 (mek6) Activated Mutant (S207D, T211D)
3. 3eqi: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Binary Complex with Adp and MG2P
4. 3eqh: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Ternary Complex with U0126, Adp and MG2P
5. 3eqg: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Ternary Complex with Pd, Adp and MG2P
6. 3eqf: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Binary Complex with K252A and MG2P
7. 3eqd: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Binary Complex with Atp-gs and MG2P
8. 3eqc: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Ternary Complex with Compound 1, Atp-gs and MG2P
9. 3eqb: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Complex with Ligand and Mgatp
10. 3enm: The Structure of The MAP2K Mek6 Reveals an Autoinhibitory Dimer
11. 3e8n: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) Complexed with a Potent Inhibitor Rdea119 and Mgatp
12. 3dy7: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Complex with Ligand and Mgatp
13. 3dv3: Mek1 with Pf-04622664 Bound
14. 3alo: Crystal Structure of Human Non-phosphorylated Mkk4 Kinase Domain Ternary Complex with Amp-pnp and P38 Peptide
15. 3aln: Crystal Structure of Human Non-phosphorylated Mkk4 Kinase Domain Complexed with Amp-pnp
16. 2vkn: Yeast Sho1 Sh3 Domain Complexed with a Peptide from Pbs2
17. 7jv1: Crystal Structure of Ksr1:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Aps-9-95-1
18. 7jv0: Crystal Structure of Ksr1:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Pd0325901
19. 7juz: Crystal Structure of Ksr1:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Selumetinib
20. 7juy: Crystal Structure of Ksr1:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Cobimetinib
21. 7jux: Crystal Structure of Ksr1:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Trametinib
22. 7juw: Crystal Structure of Ksr1:mek1 in Complex with Amp-pnp
23. 7juv: Crystal Structure of Ksr2:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Aps-9-95-1
24. 7juu: Crystal Structure of Ksr2:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Pd0325901
25. 7jut: Crystal Structure of Ksr2:mek1 in Complex with Anp-pnp, and Allosteric Mek Inhibitor Selumetinib
26. 7jus: Crystal Structure of Ksr2:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Cobimetinib
27. 7jur: Crystal Structure of Ksr2:mek1 in Complex with Amp-pnp, and Allosteric Mek Inhibitor Trametinib
28. 7juq: Crystal Structure of Ksr2:mek1 in Complex with Adp
29. 7cbx: Crystal Structure of MAP2K7 Complexed with a Covalent Inhibitor 12
30. 2p55: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in a Complex with Ligand and Mgatp
31. 6yz4: Crystal Structure of Mkk7 (MAP2K7) with Ibrutinib Bound at Allosteric Site
32. 6yg7: Crystal Structure of Mkk7 (MAP2K7) Covalently Bound with Type-ii Inhibitor Sb1-g-23
33. 6yg6: Crystal Structure of Mkk7 (MAP2K7) Covalently Bound with Type-ii Inhibitor Tl10-105
34. 6yg5: Crystal Structure of Mkk7 (MAP2K7) in Complex with Asc69
35. 6yg4: Crystal Structure of Mkk7 (MAP2K7) in Complex with K00007
36. 6yg3: Crystal Structure of Mkk7 (MAP2K7) Covalently Bound with Cpt1-70-1
37. 6yg2: Crystal Structure of Mkk7 (MAP2K7) in Complex with Ibrutnib, with Covalent and Allosteric Binding Modes
38. 6yg1: Crystal Structure of Mkk7 (MAP2K7) in an Active State, Allosterically Triggered by The N-terminal Helix
39. 6yg0: Crystal Structure of S287D,T291D Mkk7 (MAP2K7), Apo Form
40. 6yfz: Crystal Structure of Mkk7 (MAP2K7), Apo Form
41. 2dyl: Crystal Structure of Human Mitogen-activated Protein Kinase Kinase 7 Activated Mutant (S287D, T291D)
42. 2o2v: Crystal Structure of The Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-PHOX) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-PHOX)
43. 2npt: Crystal Structure of The Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-PHOX) with Human Mitogen Activated Protein Kinase Kinase Kinase 2 Phox Domain (MAP3K2-PHOX)
44. 5z1e: MAP2K7 C218S Mutant-inhibitor
45. 5z1d: MAP2K7 C276S Mutant-inhibitor
46. 6x2x: Crystal Structure of MEK1NES Peptide Bound to CRM1(E571K)
47. 6x2s: Crystal Structure of Mek1(nq)nes Peptide Bound to Crm
48. 6x2p: Crystal Structure of The MEK1NES Peptide Bound to Crm1
49. 6v2w: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp
50. 2y4i: Ksr2-mek1 Heterodimer
51. 3orn: Mitogen-activated Protein Kinase Kinase 1 (mek1) in Complex with Ch4987655 and Mgamp-pnp
52. 3pp1: Crystal Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek 1) in Complex with Ligand and Mgatp
53. 3os3: Mitogen-activated Protein Kinase Kinase 1 (mek1) in Complex with Ch4858061 and Mgatp
54. 6u2g: Braf-mek Complex with Amp-pcp Bound to Braf
55. 6qhr: Structure of The Mitogen Activated Kinase Kinase 7 in Complex with Pyrazolopyrimidine 1m
56. 6qho: Dual Specificity Mitogen-activated Protein Kinase Kinase 7 in Complex with Pyrazolopyrimidine 1a
57. 6qg7: Structure of The Mitogen Activated Kinase Kinase 7 in Complex with Pyrazolopyrimidine 1k
58. 6qg4: Structure of The Mitogen Activated Kinase Kinase 7 in Complex with Pyrazolopyrimidine Inhibitor 1h
59. 6qft: Structure of The Mitogen Activated Kinase Kinase 7 in Complex with Pyrazolopyrimidin 1b
60. 6qfr: Structure of The Mitogen Activated Kinase Kinase 7 Dfg-out Conformation
61. 6qfl: Structure of The Mitogen Activated Kinase Kinase 7 Active Conformation
62. 6q0t: Structure of a Mapk Pathway Complex
63. 6q0j: Structure of a Mapk Pathway Complex
64. 6pp9: Crystal Structure of Braf:mek1 Complex
65. 2y8o: Crystal Structure of Human P38ALPHA Complexed with a Mapk Docking Peptide
66. 3sls: Crystal Structure of Human Mek-1 Kinase in Complex with Ucb1353770 and Amppnp
67. 3vn9: Rifined Crystal Structure of Non-phosphorylated MAP2K6 in a Putative Auto-inhibition State
68. 6nyb: Structure of a Mapk Pathway Complex
69. 3v01: Discovery of Novel Allosteric Mek Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions.
70. 3v04: Discovery of Novel Allosteric Mek Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions.
71. 3vut: Crystal Structures of Non-phosphorylated MAP2K4
72. 6ib2: The Structure of Mkk7 in Complex with The Covalent 4-amino- Pyrazolopyrimidine 4a
73. 6ib0: The Structure of Mkk7 in Complex with The Covalent 4-amino- Pyrazolopyrimidine 3a
74. 4an2: Crystal Structures of Human Mek1 with Carboxamide-based Allosteric Inhibitor Xl518 (gdc-0973), or Related Analogs.
75. 4an3: Crystal Structures of Human Mek1 with Carboxamide-based Allosteric Inhibitor Xl518 (gdc-0973), or Related Analogs.
76. 4an9: Crystal Structures of Human Mek1 with Carboxamide-based Allosteric Inhibitor Xl518 (gdc-0973), or Related Analogs.
77. 4anb: Crystal Structures of Human Mek1 with Carboxamide-based Allosteric Inhibitor Xl518 (gdc-0973), or Related Analogs.
78. 4h3q: Crystal Structure of Human Erk2 Complexed with a Mapk Docking Peptide
79. 4ic7: Crystal Structure of The Erk5 Kinase Domain in Complex with an Mkk5 Binding Fragment
80. 4ark: Crystal Structure of The Catalytic Domain of Human Map Kinase Kinase 1 (mek1) in Complex with a Small Molecule Inhibitor and Adp
81. 3zls: Crystal Structure of Mek1 in Complex with Fragment 6
82. 3zlw: Crystal Structure of Mek1 in Complex with Fragment 3
83. 3zlx: Crystal Structure of Mek1 in Complex with Fragment 18
84. 3zly: Crystal Structure of Mek1 in Complex with Fragment 8
85. 3zm4: Crystal Structure of Mek1 in Complex with Fragment 1
86. 4bf2: Crystal Structures of Ask1-inhibitor Complexes
87. 4lmn: Crystal Structure of Mek1 Kinase Bound to Gdc0973
88. 3vvh: X-ray Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1) in Complex with an Inhibitor and Mgatp
89. 3w8q: Structure of The Human Mitogen-activated Protein Kinase Kinase 1 (mek1)
90. 3wig: Human Mek1 Kinase in Complex with Ch5126766 and Mgamp-pnp
91. 4mne: Crystal Structure of The Braf:mek1 Complex
92. 5y90: MAP2K7 Mutant -C218S
93. 5y8u: Crystal Structure of The C276S Mutant of MAP2K7
94. 4u7z: Mitogen-activated Protein Kinase Kinase (mek1) Bound to G805
95. 4u80: Mek 1 Kinase Bound to G799
96. 4u81: Mek1 Kinase Bound to Small Molecule Inhibitor G659
97. 5kkr: Ksr2:mek1 Complex Bound to The Small Molecule Aps-2-79
98. 5j0a: Crystal Structure of Pdz-binding Kinase
99. 5hze: Mek1 Adopts Dfg-out Conformation When Bound to an Analog of E6201.
100. 5eym: Mek1 in Complex with Bi 847325
101. 5etf: Structure of Dead Kinase Mapk14 with Bound The Kim Domain of Mkk6
102. 5bx0: An Automated Microscale Thermophoresis Screening Approach for Fragment-based Lead Discovery
103. 3wzu: The Structure of MAP2K7 in Complex with 5z-7-oxozeaenol
104. 5b2m: A Crucial Role of Cys218 in The Stabilization of an Unprecedented Auto-inhibition Form of MAP2K7
105. 5b2l: A Crucial Role of Cys218 in The Stabilization of an Unprecedented Auto-inhibition Form of MAP2K7
106. 5b2k: A Crucial Role of Cys218 in The Stabilization of an Unprecedented Auto-inhibition Form of MAP2K7
107. 7b3m: Mek1 in Complex with Compound 6
108. 7b7r: Mek1 in Complex with Compound 4
109. 7b94: Mek1 in Complex with Compound 6
110. 7b9l: Mek1 in Complex with Compound 23
111. 7m0t: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp and Selumetinib
112. 7m0u: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp and Binimetinib
113. 7m0v: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp and Cobimetinib
114. 7m0w: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp and Pimasertib
115. 7m0x: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp and Pd0325901
116. 7m0y: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp and Trametinib
117. 7m0z: Crystal Structure of The Braf:mek1 Kinases in Complex with Amppnp and Ch5126766