EC 2.7.4.9 - ATP:dTMP phosphotransferase (dTMP kinase)

3D structures of EC 2.7.4.9 - dTMP kinase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1e2d: Human Thymidylate Kinase Complexed with Thymidine Monophosphate, Adenosine Diphosphate and a Magnesium-ion
2. 1e2e: Human Thymidylate Kinase Complexed with Thymidine Monophosphate, Adenosine Diphosphate,a Magnesium-ion and Alf3
3. 1e2f: Human Thymidylate Kinase Complexed with Thymidine Monophosphate, Adenosine Diphosphate and a Magnesium-ion
4. 1e2g: Human Thymidylate Kinase Complexed with Adp, Tdp and a Magnesium-ion
5. 1e2q: Human Thymidylate Kinase Complexed with TP5A and a Magnesium-ion
6. 1e98: Wild Type Human Thymidylate Kinase Complexed with Aztmp and Adp
7. 1e99: Human Thymidylate Kinase Complexed with Aztmp and Adp
8. 1e9a: Human Thymidylate Kinase Complexed with The Bisubstrate Inhibitor AZTP5A
9. 1e9b: Human Thymidylate Kinase Complexed with Aztmp and Appnp
10. 1e9c: Mutant Human Thymidylate Kinase Complexed with Tmp and Appnp
11. 1e9d: Mutant Human Thymidylate Kinase (F105Y) Complexed with Aztmp and Adp
12. 1e9e: Mutant Human Thymidylate Kinase (F105Y) Complexed with Dtmp and Adp
13. 1e9f: Mutant Human Thymidylate Kinase Complexed with Tmp and Adp
14. 1g3u: Crystal Structure of Mycobacterium Tuberculosis Thymidylate Kinase Complexed with Thymidine Monophosphate (tmp)
15. 1gsi: Crystal Structure of Mycobacterium Tuberculosis Thymidylate Kinase Complexed with Thymidine Monophosphate (tmp)
16. 1gtv: Crystal Structure of Mycobacterium Tuberculosis Thymidylate Kinase Complexed with Thymidine-5'-diphosphate (tdp)
17. 5tmp: Complex of E. Coli Thymidylate Kinase with The Bisubstrate Inhibitor AZTP5A
18. 4tmk: Complex of E. Coli Thymidylate Kinase with The Bisubstrate Inhibitor TP5A
19. 3tmk: Crystal Structure of Yeast Thymidylate Kinase Complexed with The Bisubstrate Inhibitor TP5A at 2.0 a Resolution: Implications for Catalysis and Azt Activation
20. 3n2i: 2.25 Angstrom Resolution Crystal Structure of a Thymidylate Kinase (tmk) from Vibrio Cholerae O1 Biovar Eltor Str. N16961 in Complex with Thymidine
21. 1mrn: Crystal Structure of Mycobacterium Tuberculosis Thymidylate Kinase Complexed with Bisubstrate Inhibitor (TP5A)
22. 1mrs: Crystal Structure of Mycobacterium Tuberculosis Thymidylate Kinase Complexed with 5-CH2OH Deoxyuridine Monophosphate
23. 1n5i: Crystal Structure of Inactive Mycobacterium Tuberculosis Thymidylate Kinase Complexed with Thymidine Monophosphate (tmp) at Ph 4.6 (resolution 1.85 A)
24. 1n5j: Crystal Structure of Mycobacterium Tuberculosis Thymidylate Kinase Complexed with Thymidine Diphosphate (tdp) and Thymidine Triphosphate (ttp) at Ph 5.4 (1.85 a Resolution)
25. 1n5k: Crystal Structure of Mycobacterium Tuberculosis Thymidylate Kinase Crystallized in Sodium Malonate (resolution 2.1 A)
26. 1n5l: Crystal Structure of Mycobacterium Tuberculosis Thymidylate Kinase Crystallized in Sodium Malonate, after Catalysis in The Crystal (2.3 a Resolution)
27. 3lv8: 1.8 Angstrom Resolution Crystal Structure of a Thymidylate Kinase (tmk) from Vibrio Cholerae O1 Biovar Eltor Str. N16961 in Complex with Tmp, Thymidine-5'-diphosphate and Adp
28. 3ld9: Crystal Structure of Thymidylate Kinase from Ehrlichia Chaffeensis at 2.15a Resolution
29. 1nmx: Crystal Structure of Human Thymidylate Kinase with Fltmp and Adp
30. 1nmy: Crystal Structure of Human Thymidylate Kinase with Fltmp and Appnhp
31. 1nmz: Crystal Structure of Human Thymidylate Kinase with NH2TMP and Appnhp
32. 1nn0: Crystal Structure of Human Thymidylate Kinase with Ddtmp and Adp
33. 1nn1: Crystal Structure of Human Thymidylate Kinase with Ddtmp and Appnhp
34. 1nn3: Crystal Structure of Human Thymidylate Kinase with D4TMP + Adp
35. 1nn5: Crystal Structure of Human Thymidylate Kinase with D4TMP + Appnhp
36. 3hjn: Crystal Structure of Thymidylate Kinase in Complex with Dtdp and Adp from Thermotoga Maritima
37. 1tmk: Yeast Thymidylate Kinase Complexed with Thymidine Monophosphate (dtmp)
38. 1w2g: Crystal Structure of Mycobacterium Tuberculosis Thymidylate Kinase Complexed with Deoxythymidine (dt) (2.1 a Resolution)
39. 1w2h: Crystal Structure of Mycobacterium Tuberculosis Thymidylate Kinase Complexed with Azidothymidine Monophosphate (azt-mp) (2.0 a Resolution)
40. 2wwi: Plasmodium Falciparum Thymidylate Kinase in Complex with Aztmp and Adp
41. 2wwh: Plasmodium Falciparum Thymidylate Kinase in Complex with AP5DT
42. 2wwg: Plasmodium Falciparum Thymidylate Kinase in Complex with Dgmp and Adp
43. 2wwf: Plasmodium Falciparum Thymidylate Kinase in Complex with Tmp and Adp
44. 2w0s: Crystal Structure of Vaccinia Virus Thymidylate Kinase Bound to Brivudin-5'-monophosphate
45. 2v54: Crystal Structure of Vaccinia Virus Thymidylate Kinase Bound to Tdp
46. 2tmk: Yeast Thymidylate Kinase Complexed with 3'-azido-3'- Deoxythymidine Monophosphate (azt-mp)
47. 2ccg: Crystal Structure of His-tagged S. Aureus Thymidylate Kinase Complexed with Thymidine Monophosphate (tmp)
48. 2ccj: Crystal Structure of S. Aureus Thymidylate Kinase Complexed with Thymidine Monophosphate
49. 2cck: Crystal Structure of Unliganded S. Aureus Thymidylate Kinase
50. 2plr: Crystal Structure of Dtmp Kinase (st1543) from Sulfolobus Tokodaii Strain7
51. 2pbr: Crystal Structure of Thymidylate Kinase (aq_969) from Aquifex Aeolicus Vf5
52. 6yt1: Mtb Tmk Crystal Structure in Complex with Compound 26
53. 5zb4: Crystal Structure of Thymidylate Kinase in Complex with Adp and Tmp from Thermus Thermophilus Hb8
54. 5zb0: Crystal Structure of Thymidylate Kinase in Complex with Adp and Tdp from Thermus Thermophilus Hb8
55. 5zax: Crystal Structure of Thymidylate Kinase in Complex with Adp, Tdp and Tmp from Thermus Thermophilus Hb8
56. 2xx3: Human Thymidylate Kinase Complexed with Thymidine Butenyl Phosphonate Monophosphate and Adp
57. 3v9p: Crystal Structure of Thymidylate Kinase from Burkholderia Thailandensis
58. 3uwk: Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas Aeruginosa Thymidylate Kinase: from Hit to Lead Generation
59. 3uwo: Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas Aeruginosa Thymidylate Kinase: from Hit to Lead Generation
60. 3uxm: Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas Aeruginosa Thymidylate Kinase: from Hit to Lead Generation
61. 4dwj: Crystal Structure of Thymidylate Kinase from Staphylococcus Aureus in Complex with Thymidine Monophosphate
62. 4e5u: The Crystal Structure of Thymidylate Kinase from Pseudomonas Aeruginosa Pao1 in Complex with Thymidine Monophosphate.
63. 4eaq: Crystal Structure of Thymidylate Kinase from Staphylococcus Aureus in Complex with 3'-azido-3'-deoxythymidine-5'-monophosphate
64. 4edh: The Crystal Structure of Thymidylate Kinase from Pseudomonas Aeruginosa Pao1 in Complex with Adp,tmp and Mg.
65. 4esh: The Crystal Structure of Thymidylate Kinase from Pseudomonas Aeruginosa Pao1 in Complex with Deoxythymidine.
66. 4f4i: Crystal Structure of Thymidylate Kinase from Staphylococcus Aureus in Apo-form
67. 4gmd: The Crystal Structure of Thymidylate Kinase from Pseudomonas Aeruginosa Pao1 in Complex with Azt Monophosphate
68. 4gfd: Thymidylate Kinase (tmk) from S. Aureus in Complex with Tk-666
69. 4gsy: Crystal Structure of Thymidylate Kinase from Staphylococcus Aureus Bound to Inhibitor.
70. 4hdc: Discovery of Selective and Potent Inhibitors of Gram-positive Bacterial Thymidylate Kinase (tmk: Compound 41)
71. 4hej: Discovery of Selective and Potent Inhibitors of Gram-positive Bacterial Thymidylate Kinase (tmk): Compund 16
72. 4hlc: Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram- Positive Thymidylate Kinase (tmk): Compound 5
73. 4hld: Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram- Positive Thymidylate Kinase (tmk): Compound 11
74. 2yof: Plasmodium Falciparum Thymidylate Kinase in Complex with a (thio)urea-beta-deoxythymidine Inhibitor
75. 2yog: Plasmodium Falciparum Thymidylate Kinase in Complex with a (thio)urea-alpha-deoxythymidine Inhibitor
76. 2yoh: Plasmodium Falciparum Thymidylate Kinase in Complex with a Urea-alpha-deoxythymidine Inhibitor
77. 4mqb: Crystal Structure of Thymidylate Kinase from Staphylococcus Aureus in Complex with 2-(n-morpholino)ethanesulfonic Acid
78. 5xt8: Magnesium Bound Apo Structure of Thymidylate Kinase (form I) from Thermus Thermophilus Hb8
79. 4qg7: S.aureus Tmk in Complex with a Potent Inhibitor Compound 18, 2-(3- Chlorophenoxy)-3-methoxy-4-{[(3s)-3-(5-methyl-2,4-dioxo-3,4- Dihydropyrimidin-1(2h)-yl)piperidin-1-yl]methyl}benzoic Acid
80. 4qga: S.aureus Tmk in Complex with Potent Inhibitor Compound 19, 2-(3- Chlorophenoxy)-3-fluoro-4-{[(3s)-3-(5-methyl-2,4-dioxo-3,4- Dihydropyrimidin-1(2h)-yl)piperidin-1-yl]methyl}benzoic Acid
81. 4qgf: S.aureus Tmk in Complex with The Potent Inhibitor Compound 38, 2-(3- Chlorophenoxy)-3-methoxy-4-{(1r)-1-[(3s)-3-(5-methyl-2,4-dioxo-3,4- Dihydropyrimidin-1(2h)-yl)piperidin-1-yl]propyl}benzoic Acid
82. 4qgg: Tmk in Complex with Compound 46, 2-(3-chlorophenoxy)-3-fluoro-4-{(1r)- 3-methyl-1-[(3s)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2h)- Yl)piperidin-1-yl]butyl}benzoic Acid
83. 4qgh: S.aureus Tmk in Complex with Potent Inhibitor Compound 47
84. 5xbh: Crystal Structure of R145E Mutant of Thymidylate Kinase (aq_969) from Aquifex Aeolicus Vf5
85. 5xb5: Crystal Structure of R90A Mutant of Thymidylate Kinase (aq_969) from Aquifex Aeolicus Vf5
86. 5xb3: Adp-dtmp Bound Crystal Structure of Thymidylate Kinase (aq_969) from Aquifex Aeolicus Vf5
87. 5xb2: Adp-mg-f-dtmp Bound Crystal Structure of Thymidylate Kinase (aq_969) from Aquifex Aeolicus Vf5
88. 5xal: Y99F Mutant of Thermus Thermophilus Hb8 Thymidylate Kinase
89. 5xak: Crystal Structure (form Ii) of Thymidylate Kinase from Thermus Thermophilus Hb8
90. 5xai: Dtmp Bound Crystal Structure of Thymidylate Kinase (aq_969) from Aquifex Aeolicus Vf5
91. 5x99: T18V Mutant of Thermus Thermophilus Hb8 Thymidylate Kinase
92. 5x98: Y162F Mutant of Thermus Thermophilus Hb8 Thymidylate Kinase
93. 5x8v: Y92H Mutant of Thermus Thermophilus Hb8 Thymidylate Kinase
94. 5x8k: V158T Mutant of Thermus Thermophilus Hb8 Thymidylate Kinase
95. 5x8j: K16M Mutant of Thermus Thermophilus Hb8 Thymidylate Kinase
96. 5x8d: D90L Mutant of Thermus Thermophilus Hb8 Thymidylate Kinase
97. 5x8c: Amppcp and Tmp Bound Crystal Structure of Thymidylate Kinase from Thermus Thermophilus Hb8
98. 5x8b: Crystal Structure of Atp-tmp and Adp Bound Thymidylate Kinase from Thermus Thermophilus Hb8
99. 5x8a: Crystal Structure of Atp Bound Thymidylate Kinase from Thermus Thermophilus Hb8
100. 5x86: Crystal Structure of Tmp Bound Thymidylate Kinase from Thermus Thermophilus Hb8
101. 5x7j: Crystal Structure of Thymidylate Kinase from Thermus Thermophilus Hb8
102. 5nrq: Mtb Tmk Crystal Structure in Complex with Compound 33
103. 5nrn: Mtb Tmk Crystal Structure in Complex with Compound 3
104. 5nr7: Mtb Tmk Crystal Structure in Complex with Compound 43
105. 5nq5: Mtb Tmk Crystal Structure in Complex with Compound 1
106. 5h70: Crystal Structure of Adp Bound Dtmp Kinase (st1543) from Sulfolobus Tokodaii Strain7
107. 5h5k: Atp and Cmp Bound Crystal Structure of Thymidylate Kinase (aq_969) from Aquifex Aeolicus Vf5
108. 5h5b: Citrate Ion Bound Crystal Structure of Thymidylate Kinase (aq_969) from Aquifex Aeolicus Vf5
109. 5h56: Adp and Dtdp Bound Crystal Structure of Thymidylate Kinase (aq_969) from Aquifex Aeolicus Vf5
110. 4nzy: Crystal Structure (type-2) of Dtmp Kinase (st1543) from Sulfolobus Tokodaii Strain7
111. 4unp: Mtb Tmk in Complex with Compound 34
112. 4xwa: Tmk from S.aureus in Complex with The Piperidinyl Thymine Class Inhibitor with a C5 Ethyl-amine
113. 4rzu: Crystal Structure of Adp Bound Dtmp Kinase (st1543) from Sulfolobus Tokodaii Strain7
114. 4rzx: Crystal Structure (type-3) of Dtmp Kinase (st1543) from Sulfolobus Tokodaii Strain7
115. 4s2e: Phosphate Ion Bound Crystal Structure of Thymidylate Kinase (aq_969) from Aquifex Aeolicus Vf5
116. 4s35: Amppcp and Tmp Bound Crystal Structure of Thymidylate Kinase (aq_969) from Aquifex Aeolicus Vf5
117. 4unn: Mtb Tmk in Complex with Compound 8
118. 4unq: Mtb Tmk in Complex with Compound 36
119. 4unr: Mtb Tmk in Complex with Compound 23
120. 4uns: Mtb Tmk in Complex with Compound 40