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enzyme (lysozyme)

 
Enzymes
  Enzyme classes:
  EC 1: Oxidoreductases
  EC 2: Transferases
  EC 3: Hydrolases
    EC 3.1
      EC 3.1.1
      EC 3.1.2
      EC 3.1.3
      EC 3.1.4
        EC 3.1.4.1
        EC 3.1.4.2
        EC 3.1.4.3
        EC 3.1.4.4
        EC 3.1.4.5
        EC 3.1.4.6
        EC 3.1.4.7
        EC 3.1.4.8
        EC 3.1.4.9
        EC 3.1.4.10
        EC 3.1.4.11
        EC 3.1.4.12
        EC 3.1.4.13
        EC 3.1.4.14
        EC 3.1.4.15
        EC 3.1.4.16
        EC 3.1.4.17
        EC 3.1.4.18
        EC 3.1.4.19
        EC 3.1.4.20
        EC 3.1.4.21
        EC 3.1.4.22
        EC 3.1.4.23
        EC 3.1.4.24
        EC 3.1.4.25
        EC 3.1.4.26
        EC 3.1.4.27
        EC 3.1.4.28
        EC 3.1.4.29
        EC 3.1.4.30
        EC 3.1.4.31
        EC 3.1.4.32
        EC 3.1.4.33
        EC 3.1.4.34
        EC 3.1.4.35
        EC 3.1.4.36
        EC 3.1.4.37
        EC 3.1.4.38
        EC 3.1.4.39
        EC 3.1.4.40
        EC 3.1.4.41
        EC 3.1.4.42
        EC 3.1.4.43
        EC 3.1.4.44
        EC 3.1.4.45
        EC 3.1.4.46
        EC 3.1.4.47
        EC 3.1.4.48
        EC 3.1.4.49
        EC 3.1.4.50
        EC 3.1.4.51
        EC 3.1.4.52
      EC 3.1.5
      EC 3.1.6
      EC 3.1.7
      EC 3.1.8
      EC 3.1.11
      EC 3.1.13
      EC 3.1.14
      EC 3.1.15
      EC 3.1.16
      EC 3.1.21
      EC 3.1.22
      EC 3.1.23
      EC 3.1.24
      EC 3.1.25
      EC 3.1.26
      EC 3.1.27
      EC 3.1.30
      EC 3.1.31
    EC 3.2
    EC 3.3
    EC 3.4
    EC 3.5
    EC 3.6
    EC 3.7
    EC 3.8
    EC 3.9
    EC 3.10
    EC 3.11
    EC 3.12
    EC 3.13
  EC 4: Lyases
  EC 5: Isomerases
  EC 6: Ligases
  General information:
  Catalytic mechanism
  Enzyme kinetics
  Inhibitors
  Enzymes in industry

EC 3.1.4.17 - 3',5'- cyclic- nucleotide 5'- nucleotidohydrolase (3',5'- cyclic- nucleotide phosphodiesterase)



3D structures of EC 3.1.4.17 - 3',5'-cyclic-nucleotide phosphodiesterase in Protein Data Bank

updated: 22 January 2021, 10:46

In total: 255 PDB structures of EC 3.1.4.17 - 3',5'-cyclic-nucleotide phosphodiesterase:
  1. 1f0j: Catalytic Domain of Human Phosphodiesterase 4B2B
  2. 1ksg: Complex of Arl2 and Pde Delta, Crystal Form 1
  3. 1ksh: Complex of Arl2 and Pde Delta, Crystal Form 2 (native)
  4. 1ksj: Complex of Arl2 and Pde Delta, Crystal Form 2 (semet)
  5. 1loi: N-terminal Splice Region of Rat C-amp Phosphodiesterase, Nmr, 7 Structures
  6. 1mkd: Crystal Structure of PDE4D Catalytic Domain and Zardaverine Complex
  7. 3ly2: Catalytic Domain of Human Phosphodiesterase 4b in Complex with a Coumarin-based Inhibitor
  8. 3lxg: Crystal Structure of Rat Phosphodiesterase 10a in Complex with Ligand Web-3
  9. 3kkt: Crystal Structure of Human PDE4B with 5-[3-[(1s,2s,4r)- Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp Henyl]tetrahydro- 2(1h)-pyrimidinone Reveals Ordering of The C-terminal Helix Residues 502-509.
  10. 3k4s: The Structure of The Catalytic Domain of Human PDE4D with 4- (3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone
  11. 1oyn: Crystal Structure of PDE4D2 in Complex with (r,s)-rolipram
  12. 3jwr: Crystal Structure of Chimeric Pde5/pde6 Catalytic Domain Complexed with 3-isobutyl-1-methylxanthine (ibmx) and Pde6 Gamma-subunit Inhibitory Peptide 70-87.
  13. 3itu: HPDE2A Catalytic Domain Complexed with Ibmx
  14. 3itm: Catalytic Domain of HPDE2A
  15. 3ibj: X-ray Structure of PDE2A
  16. 3ib8: Crystal Structure of Full Length Rv0805 in Complex with 5'- Amp
  17. 3ib7: Crystal Structure of Full Length Rv0805
  18. 1ptw: The Crystal Structure of Amp-bound Pde4 Suggests a Mechanism for Phosphodiesterase Catalysis
  19. 3iak: Crystal Structure of Human Phosphodiesterase 4d (PDE4D) with Papaverine.
  20. 3iad: Crystal Structure of Human Phosphodiesterase 4d with Bound Allosteric Modulator
  21. 3i8v: Crystal Structure of Human PDE4A with 4-(3-butoxy-4- Methoxyphenyl)methyl-2-imidazolidone
  22. 1q9m: Three Dimensional Structures of PDE4D in Complex with Roliprams and Implication on Inhibitor Selectivity
  23. 3hr1: Discovery of Novel Inhibitors of PDE10A
  24. 3hqz: Discovery of Novel Inhibitors of PDE10A
  25. 3hqy: Discovery of Novel Inhibitors of PDE10A
  26. 3hqw: Discovery of Novel Inhibitors of PDE10A
  27. 3hmv: Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with a Tetrahydrobenzothiophene Inhibitor
  28. 3gwt: Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with a Quinoline Inhibitor
  29. 1rkp: Crystal Structure of PDE5A1-IBMX
  30. 1ro6: Crystal Structure of PDE4B2B Complexed with Rolipram (r & S)
  31. 1ro9: Crystal Structures of The Catalytic Domain of Phosphodiesterase 4B2B Complexed with 8-br-amp
  32. 1ror: Crystal Structures of The Catalytic Domain of Phosphodiesterase 4B2B Complexed with Amp
  33. 3g58: Crystal Structure of Human Phosphodiesterase 4d with D155988/pmnpq
  34. 3g4l: Crystal Structure of Human Phosphodiesterase 4d with Roflumilast
  35. 3g4k: Crystal Structure of Human Phosphodiesterase 4d with Rolipram
  36. 3g4i: Crystal Structure of Human Phosphodiesterase 4d with D155871
  37. 3g4g: Crystal Structure of Human Phosphodiesterase 4d with Regulatory Domain and D155871
  38. 3g45: Crystal Structure of Human Phosphodiesterase 4b with Regulatory Domain and D155988
  39. 3g3n: PDE7A Catalytic Domain in Complex with 3-(2,6- Difluorophenyl)-2-(methylthio)quinazolin-4(3h)-one
  40. 3frg: Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with a Quinoline Inhibitor
  41. 1so2: Catalytic Domain of Human Phosphodiesterase 3b in Complex with a Dihydropyridazine Inhibitor
  42. 1soj: Catalytic Domain of Human Phosphodiesterase 3b in Complex with Ibmx
  43. 1t9r: Catalytic Domain of Human Phosphodiesterase 5a
  44. 1t9s: Catalytic Domain of Human Phosphodiesterase 5a in Complex with Gmp
  45. 1taz: Catalytic Domain of Human Phosphodiesterase 1b
  46. 1tb5: Catalytic Domain of Human Phosphodiesterase 4b in Complex with Amp
  47. 1tb7: Catalytic Domain of Human Phosphodiesterase 4d in Complex with Amp
  48. 1tbb: Catalytic Domain of Human Phosphodiesterase 4d in Complex with Rolipram
  49. 1tbf: Catalytic Domain of Human Phosphodiesterase 5a in Complex with Sildenafil
  50. 3ecn: Crystal Structure of PDE8A Catalytic Domain in Complex with Ibmx
  51. 3ecm: Crystal Structure of The Unliganded PDE8A Catalytic Domain
  52. 1udt: Crystal Structure of Human Phosphodiesterase 5 Complexed with Sildenafil(viagra)
  53. 1udu: Crystal Structure of Human Phosphodiesterase 5 Complexed with Tadalafil(cialis)
  54. 1uho: Crystal Structure of Human Phosphodiesterase 5 Complexed with Vardenafil(levitra)
  55. 3d3p: Crystal Structure of PDE4B Catalytic Domain in Complex with a Pyrazolopyridine Inhibitor
  56. 2zmf: Crystal Structure of The C-terminal Gaf Domain of Human Phosphodiesterase 10a
  57. 1xlx: Catalytic Domain of Human Phosphodiesterase 4b in Complex with Cilomilast
  58. 1xlz: Catalytic Domain of Human Phosphodiesterase 4b in Complex with Filaminast
  59. 1xm4: Catalytic Domain of Human Phosphodiesterase 4b in Complex with Piclamilast
  60. 1xm6: Catalytic Domain of Human Phosphodiesterase 4b in Complex with (r)-mesopram
  61. 1xmu: Catalytic Domain of Human Phosphodiesterase 4b in Complex with Roflumilast
  62. 1xmy: Catalytic Domain of Human Phosphodiesterase 4b in Complex with (r)-rolipram
  63. 1xn0: Catalytic Domain of Human Phosphodiesterase 4b in Complex with (r,s)-rolipram
  64. 1xom: Catalytic Domain of Human Phosphodiesterase 4d in Complex with Cilomilast
  65. 1xon: Catalytic Domain of Human Phosphodiesterase 4d in Complex with Piclamilast
  66. 1xoq: Catalytic Domain of Human Phosphodiesterase 4d in Complex with Roflumilast
  67. 1xor: Catalytic Domain of Human Phosphodiesterase 4d in Complex with Zardaverine
  68. 1xos: Catalytic Domain of Human Phosphodiesterase 4b in Complex with Sildenafil
  69. 1xot: Catalytic Domain of Human Phosphodiesterase 4b in Complex with Vardenafil
  70. 1xoz: Catalytic Domain of Human Phosphodiesterase 5a in Complex with Tadalafil
  71. 1xp0: Catalytic Domain of Human Phosphodiesterase 5a in Complex with Vardenafil
  72. 1y2b: Catalytic Domain of Human Phosphodiesterase 4d in Complex with 3,5-dimethyl-1h-pyrazole-4-carboxylic Acid Ethyl Ester
  73. 1y2c: Catalytic Domain of Human Phosphodiesterase 4d in Complex with 3,5-dimethyl-1-phenyl-1h-pyrazole-4-carboxylic Acid Ethyl Ester
  74. 1y2d: Catalytic Domain of Human Phosphodiesterase 4d in Complex with 1-(4-methoxy-phenyl)-3,5-dimethyl-1h-pyrazole-4- Carboxylic Acid Ethyl Ester
  75. 1y2e: Catalytic Domain of Human Phosphodiesterase 4d in Complex with 1-(4-amino-phenyl)-3,5-dimethyl-1h-pyrazole-4- Carboxylic Acid Ethyl Ester
  76. 1y2h: Catalytic Domain of Human Phosphodiesterase 4b in Complex with 1-(2-chloro-phenyl)-3,5-dimethyl-1h-pyrazole-4- Carboxylic Acid Ethyl Ester
  77. 1y2j: Catalytic Domain of Human Phosphodiesterase 4b in Complex with 3,5-dimethyl-1-(3-nitro-phenyl)-1h-pyrazole-4- Carboxylic Acid Ethyl Ester
  78. 1y2k: Catalytic Domain of Human Phosphodiesterase 4d in Complex with 3,5-dimethyl-1-(3-nitro-phenyl)-1h-pyrazole-4- Carboxylic Acid Ethyl Ester
  79. 2wey: Human Pde-papaverine Complex Obtained by Ligand Soaking of Cross-linked Protein Crystals
  80. 1z1l: The Crystal Structure of The Phosphodiesterase 2a Catalytic Domain
  81. 1zkl: Multiple Determinants for Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases
  82. 1zkn: Structure of PDE4D2-IBMX
  83. 6zqz: [1,2,4]triazolo[1,5-a]pyrimidine Phosphodiesterase 2 Inhibitors
  84. 6znd: [1,2,4]triazolo[1,5-a]pyrimidine Phosphodiesterase 2 Inhibitors
  85. 2r8q: Structure of Lmjpdeb1 in Complex with Ibmx
  86. 2qyn: Crystal Structure of PDE4D2 in Complex with Inhibitor Npv
  87. 2chm: Crystal Structure of N2 Substituted Pyrazolo Pyrimidinones- a Flipped Binding Mode in Pde5
  88. 2pw3: Structure of The PDE4D-CAMP Complex
  89. 2ovy: Crystal Structure of The Catalytic Domain of Rat Phosphodiesterase 10a
  90. 2ovv: Crystal Structure of The Catalytic Domain of Rat Phosphodiesterase 10a
  91. 2ouy: Crystal Structure of PDE10A2 Mutant D564A in Complex with Camp.
  92. 2ouv: Crystal Structure of PDE10A2 Mutant of D564N
  93. 2ouu: Crystal Structure of PDE10A2 Mutant D674A in Complex with Cgmp
  94. 2ous: Crystal Structure of PDE10A2 Mutant D674A
  95. 2our: Crystal Structure of PDE10A2 Mutant D674A in Complex with Camp
  96. 2ouq: Crystal Structure of PDE10A2 in Complex with Gmp
  97. 2oup: Crystal Structure of PDE10A
  98. 2oun: Crystal Structure of PDE10A2 in Complex with Amp
  99. 2o8h: Crystal Structure of The Catalytic Domain of Rat Phosphodiesterase 10a
  100. 6c7j: Crystal Structure of Human Phosphodiesterase 2a with 1-(5-tert-butoxy- 2-chloro-phenyl)-n-isobutyl-4-methyl-[1,2,4]triazolo[4,3- A]quinoxaline-8-carboxamide
  101. 6c7i: Crystal Structure of Human Phosphodiesterase 2a with 1-(2-chloro-5- Methoxy-phenyl)-n-isobutyl-4-methyl-[1,2,4]triazolo[4,3- A]quinoxaline-8-carboxamide
  102. 6c7g: Crystal Structure of Human Phosphodiesterase 2a with N-(1-adamantyl)- 1-(2-chloro-5-isobutoxy-phenyl)-4-methyl-[1,2,4]triazolo[4,3- A]quinoxaline-8-carboxamide
  103. 6c7f: Crystal Structure of Human Phosphodiesterase 2a with 1-(2-chloro-5- Isobutoxy-phenyl)-n,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8- Carboxamide
  104. 6c7e: Crystal Structure of Human Phosphodiesterase 2a with 1-(2- Chlorophenyl)-n,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8- Carboxamide
  105. 6c7d: Crystal Structure of Human Phosphodiesterase 2a with N-(1-adamantyl)- 1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8- Carboxamide
  106. 6blf: Pde2 Complexed with 2-[6-fluoro-8-methylsulfonyl-9-[(1r)-1-[4- (trifluoromethyl)phenyl]ethyl]-1,2,3,4-tetrahydrocarbazol-1-yl]acetic Acid
  107. 6b98: Pde2 in Complex with Compound 1
  108. 6b97: Crystal Structure of Pde2 in Complex with Complex 9
  109. 6b96: Crystal Structure of Pde2 in Complex with Compound 16
  110. 5znl: Crystal Structure of PDE10A Catalytic Domain Complexed with Lhb-6
  111. 2fm0: Crystal Structure of PDE4D in Complex with L-869298
  112. 2fm5: Crystal Structure of PDE4D2 in Complex with Inhibitor L- 869299
  113. 2hy1: Crystal Structure of Rv0805
  114. 2hyo: Crystal Structure of Rv0805 N97A Mutant
  115. 2hyp: Crystal Structure of Rv0805 D66A Mutant
  116. 2ju4: Nmr Structure of The Gamma Subunit of Cgmp Phosphodiesterase
  117. 6kze: The Crystal Structue of PDE10A Complexed with 4d
  118. 2y0j: Triazoloquinazolines as a Novel Class of Phosphodiesterase 10a (PDE10A) Inhibitors, part 2, Lead-optimisation.
  119. 6ko1: The Crystal Structue of PDE10A Complexed with 2d
  120. 6ko0: The Crystal Structue of PDE10A Complexed with 1i
  121. 3qpn: Structure of Pde10-inhibitor Complex
  122. 3qpo: Structure of Pde10-inhibitor Complex
  123. 3qpp: Structure of Pde10-inhibitor Complex
  124. 3o56: Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with a 5- Heterocycle Pyrazolopyridine Inhibitor
  125. 3o57: Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with a 5- Heterocycle Pyrazolopyridine Inhibitor
  126. 3o0j: PDE4B in Complex with Ligand An2898
  127. 3sl3: Crystal Structure of The Apo Form of The Catalytic Domain of PDE4D2
  128. 3sl4: Crystal Structure of The Catalytic Domain of PDE4D2 with Compound 10d
  129. 3sl5: Crystal Structure of The Catalytic Domain of PDE4D2 Complexed with Compound 10d
  130. 3sl6: Crystal Structure of The Catalytic Domain of PDE4D2 with Compound 12c
  131. 3sl8: Crystal Structure of The Catalytic Domain of PDE4D2 with Compound 10o
  132. 3sn7: Highly Potent, Selective, and Orally Active Phosphodiestarase 10a Inhibitors
  133. 3sni: Highly Potent, Selective, and Orally Active Phosphodiestarase 10a Inhibitors
  134. 3snl: Highly Potent, Selective, and Orally Active Phosphodiestarase 10a Inhibitors
  135. 3ui7: Discovery of Orally Active Pyrazoloquinoline as a Potent Pde10 Inhibitor for The Management of Schizophrenia
  136. 3v9b: Crystal Structure of The Catalytic Domain of PDE4D2 with (s)-n-(3-{1- [1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4- Yl)-ethyl]-1h-pyrazl-3-yl}phenyl)acetamide
  137. 3tvx: The Structure of PDE4A with Pentoxifylline at 2.84a Resolution
  138. 3uuo: The Discovery of Potent, Selectivity, and Orally Bioavailable Pyrozoloquinolines as Pde10 Inhibitors for The Treatment of Schizophrenia
  139. 4ael: PDE10A in Complex with The Inhibitor Az5
  140. 3v93: Unliganded Structure of Tcrpdec1 Catalytic Domain
  141. 3v94: Tcrpdec1 Catalytic Domain in Complex with Inhibitor Wyq16
  142. 4dff: The Sar Development of Dihydroimidazoisoquinoline Derivatives as Phosphodiesterase 10a Inhibitors for The Treatment of Schizophrenia
  143. 4ddl: PDE10A Crystal Structure Complexed with Novel Inhibitor
  144. 6msc: Novel, Potent, Selective and Brain Penetrant Phosphodiesterase 10a Inhibitors
  145. 6msa: Novel, Potent, Selective and Brain Penetrant Phosphodiesterase 10a Inhibitors
  146. 6ke0: Crystal Structure of PDE10A in Complex with a Triazolopyrimidine Inhibitor
  147. 6kdz: Crystal Structure of PDE10A in Complex with a Triazolopyrimidine Inhibitor
  148. 6kdx: Crystal Structure of PDE10A in Complex with a Triazolopyrimidine Inhibitor
  149. 6k9u: Discovery of Pyrazolo[1,5-a]pyrimidine Derivative as a Highly Selective PDE10A Inhibitor
  150. 4fcb: Potent and Selective Phosphodiesterase 10a Inhibitors
  151. 4fcd: Potent and Selective Phosphodiesterase 10a Inhibitors
  152. 6iji: Crystal Structure of Pde10 in Complex with Inhibitor 2b
  153. 6ijh: Crystal Structure of Pde10 in Complex with Inhibitor Af-399/14387019
  154. 4hf4: Crystal Structure of PDE10A with a Biaryl Ether Inhibitor (1-(1-(3-(4- (benzo[d]thiazol-2-ylamino)phenoxy)pyrazin-2-yl)piperidin-4-yl) Ethanol)
  155. 4ajd: Identification and Structural Characterization of Pde10 Fragment Inhibitors
  156. 4ajf: Identification and Structural Characterization of Pde10 Fragment Inhibitors
  157. 4ajg: Identification and Structural Characterization of Pde10 Fragment Inhibitors
  158. 4ajm: Development of a Plate-based Optical Biosensor Methodology to Identify Pde10 Fragment Inhibitors
  159. 4jib: Crystal Structure of of Pde2-inhibitor Complex
  160. 3w5e: Crystal Structure of Phosphodiesterase 4b in Complex with Compound 31e
  161. 6ezf: Pde2 in Complex with Molecule 5
  162. 4kp6: Crystal Structure of Human Phosphodiesterase 4b (PDE4B) in Complex with a [1,3,5]triazine Derivative
  163. 6cyd: Pde2 in Complex with Compound 7
  164. 6cyc: Pde2 in Complex with Compound 5
  165. 6cyb: Pde2 in Complex with Compound 7
  166. 3wd9: Crystal Structure of Phosphodiesterase 4b in Complex with Compound 10f
  167. 3wi2: Crystal Structure of PDE10A in Complex with Inhibitor
  168. 3ws8: Crystal Structure of PDE10A in Complex with a Benzimidazole Inhibitor
  169. 3ws9: Crystal Structure of PDE10A in Complex with a Benzimdazole Inhibitor
  170. 3wyk: Crystal Structure of The Catalytic Domain of PDE10A Complexed with 3- (1-phenyl-1h-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin- 4(1h)-one
  171. 3wyl: Crystal Structure of The Catalytic Domain of PDE10A Complexed with 5- Methoxy-3-(1-phenyl-1h-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl) Pyridazin-4(1h)-one
  172. 3wym: Crystal Structure of The Catalytic Domain of PDE10A Complexed with 1- (2-fluoro-4-(1h-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1h- Pyrazol-5-yl)pyridazin-4(1h)-one
  173. 4bbx: Discovery of a Potent, Selective and Orally Active PDE10A Inhibitor for The Treatment of Schizophrenia
  174. 4c1i: Selective Inhibitors of Pde2, Pde9, and Pde10: Modulators of Activity of The Central Nervous System
  175. 4d08: PDE2A Catalytic Domain in Complex with a Brain Penetrant Inhibitor
  176. 4d09: PDE2A Catalytic Domain in Complex with a Brain Penetrant Inhibitor
  177. 4htx: Crystal Structure of Pde2 Catalytic Domain in Complex with Bay60-7550
  178. 4htz: Crystal Structure of Pde2 Catalytic Domain in Space Group P1
  179. 4lkq: Crystal Structure of PDE10A2 with Fragment Zt017
  180. 4llj: Crystal Structure of PDE10A2 with Fragment Zt214
  181. 4llk: Crystal Structure of PDE10A2 with Fragment Zt217
  182. 4llp: Crystal Structure of PDE10A2 with Fragment Zt401
  183. 4llx: Crystal Structure of PDE10A2 with Fragment Zt434
  184. 4lm0: Crystal Structure of PDE10A2 with Fragment Zt448
  185. 4lm1: Crystal Structure of PDE10A2 with Fragment Zt450
  186. 4lm2: Crystal Structure of PDE10A2 with Fragment Zt462
  187. 4lm3: Crystal Structure of PDE10A2 with Fragment Zt464
  188. 4lm4: Crystal Structure of PDE10A2 with Fragment Zt902
  189. 4mrw: Crystal Structure of PDE10A2 with Fragment Zt0120 (7-chloroquinolin-4- Ol)
  190. 4mrz: Crystal Structure of PDE10A2 with Fragment Zt0429 (4-methyl-3- Nitropyridin-2-amine)
  191. 4ms0: Crystal Structure of PDE10A2 with Fragment Zt0443 (6-chloropyrimidine- 2,4-diamine)
  192. 4msa: Crystal Structure of PDE10A2 with Fragment Zt0449 (5-nitro-1h- Benzimidazole)
  193. 4msc: Crystal Structure of PDE10A2 with Fragment Zt1595 (2-[(quinolin-7- Yloxy)methyl]quinoline)
  194. 4mse: Crystal Structure of PDE10A2 with Fragment Zt1597 (2-({[(2s)-2-methyl- 2,3-dihydro-1,3-benzothiazol-5-yl]oxy}methyl)quinoline)
  195. 4msh: Crystal Structure of PDE10A2 with Fragment Zt0143 ((2s)-4-chloro-2,3- Dihydro-1,3-benzothiazol-2-amine)
  196. 4msn: Crystal Structure of PDE10A2 with Fragment Zt0451 (8-nitroquinoline)
  197. 4muw: Crystal Structure of PDE10A with Novel Keto-benzimidazole Inhibitor
  198. 4mvh: Crystal Structure of PDE10A with Novel Keto-benzimidazole Inhibitor
  199. 4myq: Selective Inhibition of The Catalytic Domain of Human Phosphodiesterase 4b with A-33
  200. 4npv: Crystal Structure of Human PDE1B Bound to Inhibitor 7a (6,7,8- Trimethoxy-n-(pentan-3-yl)quinazolin-4-amine)
  201. 4npw: Crystal Structure of Human PDE1B Bound to Inhibitor 19a (7,8- Dimethoxy-n-[(2s)-1-(3-methyl-1h-pyrazol-5-yl)propan-2-yl]quinazolin- 4-amine)
  202. 4nw7: Pde4 Catalytic Domain
  203. 4p0n: Crystal Structure of PDE10A with a Novel Imidazo[4,5-b]pyridine Inhibitor
  204. 4p1r: Crystal Structure of PDE10A with Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors
  205. 4phw: Crystal Structure of PDE10A with 1h-benzimidazol-2-yl(4-((3- (tetrahydro-2h-pyran-4-yl)-2-pyridinyl)oxy)phenyl)methanone
  206. 5xuj: Crystal Structure of PDE10A in Complex with 7-(4-chlorophenyl)-2- Methylpyrazolo[1,5-a]pyrimidine
  207. 5xui: Crystal Structure of PDE10A in Complex with 2-methyl-5-[2-([1,2, 4]triazolo[1,5-a]pyrimidin-2-yl)et Hyl]pyrazolo[1,5-a]pyrimidin-7-ol
  208. 5xkm: Crystal Structure of Human Phosphodiesterase 2a in Complex with 6- Methyl-n-(1-(4-(trifluoromethoxy)phenyl)propyl)pyrazolo[1,5- A]pyrimidine-3-carboxamide
  209. 5w6e: PDE1B Complexed with Compound 3s
  210. 5vp1: Discovery of Clinical Candidate N-{(1s)-1-[3-fluoro-4- (trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3- Dihydropyrido[2,3-b]pyrazine-4(1h)-carboxamide (tak-915), a Highly Potent, Selective, and Brain-penetrating Phosphodiesterase 2a Inhibitor for The Treatment of Cognitive Disorders
  211. 5vp0: Discovery of Clinical Candidate N-{(1s)-1-[3-fluoro-4- (trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3- Dihydropyrido[2,3-b]pyrazine-4(1h)-carboxamide (tak-915), a Highly Potent, Selective, and Brain-penetrating Phosphodiesterase 2a Inhibitor for The Treatment of Cognitive Disorders
  212. 5uwf: Crystal Structure of Human PDE10A in Complex with Inhibitor 16d
  213. 4ojv: Crystal Structure of Unliganded Yeast Pde1
  214. 4ojx: Crystal Structure of Yeast Phosphodiesterase-1 in Complex with Gmp
  215. 5up0: Crystal Structure of Human PDE1B Catalytic Domain in Complex with Inhibitor 3 (6-(4-chlorobenzyl)-8,9,10,11-tetrahydrobenzo[4, 5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6h)-one)
  216. 5uoy: Crystal Structure of Human PDE1B Catalytic Domain in Complex with Inhibitor 16j (6-(4-methoxybenzyl)-9-((tetrahydro-2h-pyran-4-yl) Methyl)-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2, 4]triazolo[1,5-c]pyrimidin-5(6h)-one)
  217. 5u7l: Pde2 Catalytic Domain Complexed with Inhibitors
  218. 5u7k: Pde2 Catalytic Domain Complexed with Inhibitors
  219. 5u7j: Pde2 Catalytic Domain Complexed with Inhibitors
  220. 5u7i: Pde2 Catalytic Domain Complexed with Inhibitors
  221. 5u7d: Pde2 Catalytic Domain Complexed with Inhibitors
  222. 5u00: Crystal Structure of Human Phosphodiesterase 2a in Complex with 3,3- Difluoro-1-[(4-fluoro-3-iodophenyl)carbonyl]-5-{5-methyl-[1,2, 4]triazolo[1,5-a]pyrimidin-7-yl}piperidine
  223. 5tzz: Crystal Structure of Human Phosphodiesterase 2a in Complex with 1-[(3- Bromo-4-fluorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[1,2, 4]triazolo[1,5-a]pyrimidin-7-yl}piperidine
  224. 5tzx: Crystal Structure of Human Phosphodiesterase 2a in Complex with 1-[(3- Chloro-4-fluorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[1,2, 4]triazolo[1,5-a]pyrimidin-7-yl}piperidine
  225. 5tzw: Crystal Structure of Human Phosphodiesterase 2a in Complex with 1-[(3, 4-difluorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[1,2, 4]triazolo[1,5-a]pyrimidin-7-yl}piperidine
  226. 5tzh: Crystal Structure of Human Phosphodiesterase 2a in Complex with 3,3- Difluoro-1-[(4-fluorophenyl)carbonyl]-5-{5-methyl-[1,2,4]triazolo[1, 5-a]pyrimidin-7-yl}piperidine
  227. 5tzc: Crystal Structure of Human PDE2A in Complex with (5s)-1-[(3-bromo-4- Fluorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[1,2,4]triazolo[1,5- A]pyrimidin-7-yl}piperidine
  228. 5tza: Crystal Structure of Human Phosphodiesterase 2a with 3-{5-methyl-[1,2, 4]triazolo[1,5-a]pyrimidin-7-yl-1-[(naphthalene-2-yl) Carbonyl]piperidine
  229. 5tz3: Crystal Structure of Human Phosphodiesterase 2a in Complex with [1,2, 4]triazolo[1,5-a]pyrimidin-7-yl}-n-(naphthalene-2-yl)piperidine-3- Carboxamide
  230. 5k9r: PDE10A with Imidazopyrazine Inhibitor
  231. 5i2r: Human PDE10A in Complex with 3-(2-phenylpyrazol-3-yl)-1-[3- (trifluoromethoxy)phenyl]pyridazin-4-one
  232. 5edi: Human PDE10A, 6-chloro-5,8-dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl- 2h-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyridine, 2.20a, H3, Rfree=23.5%
  233. 5edh: Human PDE10A, 8-ethyl-5-methyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4- Triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine, 2.03a, H3, Rfree=22.7%
  234. 5edg: Human PDE10A in Complex with 3-(2-chloro-5-phenyl-3h-imidazol-4-yl)-1- (3-trifluoromethoxy-phenyl)-1h-pyridazin-4-one at 2.30a
  235. 5ede: Human PDE10A in Complex with 1-(4-chloro-phenyl)-3-methyl-1h-thieno[2, 3-c]pyrazole-5-carboxylic Acid (tetrahydro-furan-2-ylmethyl)-amide at 2.2a
  236. 5dh5: Pde10 Complexed with N-[(1-methylpyrazol-4-yl)methyl]-5-[[(1s,2s)-2- (2-pyridyl)cyclopropyl]methoxy]pyrazolo[1,5-a]pyrimidin-7-amine
  237. 5dh4: Pde10 Complexed with 5-chloro-n-[(2,4-dimethylthiazol-5-yl) Methyl]pyrazolo[1,5-a]pyrimidin-7-amine
  238. 5c2h: Pde10 Complexed with 6-chloro-n-[(2,4-dimethylthiazol-5-yl)methyl]-5- Methyl-2-[3-(2-quinolyl)propoxy]pyrimidin-4-amine
  239. 5c2e: Pde10 Complexed With6-chloro-n-[(2,4-dimethylthiazol-5-yl)methyl]-5- Methyl-2-[2-(2-pyridyl)ethoxy]pyrimidin-4-amine
  240. 5c2a: Pde10 Complexed with 6-chloro-2-cyclopropyl-n-[(2,4-dimethylthiazol-5- Yl)methyl]-5-methyl-pyrimidin-4-amine
  241. 5c29: Pde10 Complexed with 6-chloro-2-cyclopropyl-5-methyl-n-propyl- Pyrimidin-4-amine
  242. 5c28: Pde10 Complexed with 6-chloro-2-cyclopropyl-5-methyl-pyrimidin-4-amine
  243. 5c1w: Pde10 Complexed with 4,6-dichloro-2-cyclopropyl-5-methyl-pyrimidine
  244. 4tpm: Crystal Structure of 2-(3-alkoxy-1-azetidinyl) Quinolines as PDE10A Inhibitors
  245. 4tpp: 2-(3-alkoxy-1-azetidinyl) Quinolines as Novel PDE10A Inhibitors
  246. 5b4l: Crystal Structure of The Catalytic Domain of Human PDE10A Complexed with 1-(cyclopropylmethyl)-5-(2-(2,3-dihydro-1h-imidazo[1,2- A]benzimidazol-1-yl)ethoxy)-3-(1-phenyl-1h-pyrazol-5-yl)pyridazin- 4(1h)-one
  247. 5b4k: Crystal Structure of The Catalytic Domain of Human PDE10A Complexed with N-(4-((5-methyl-5h-pyrrolo[3,2-d]pyrimidin-4-yl)oxy)phenyl)-1h- Benzimidazol-2-amine
  248. 5b25: Crystal Structure of Human PDE1B with Inhibitor 3
  249. 5axq: Crystal Structure of The Catalytic Domain of PDE10A Complexed with Highly Potent and Brain-penetrant PDE10A Inhibitor with 2-oxindole Scaffold
  250. 5axp: Crystal Structure of The Catalytic Domain of PDE10A Complexed with 1- (2-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl)-5-methoxy-3-(1-phenyl- 1h-pyrazol-5-yl)pyridazin-4(1h)-one
  251. 4wn1: Crystal Structure of PDE10A in Complex with 1-methyl-5-(1-methyl-3- {[4-(quinolin-2-yl)phenoxy]methyl}-1h-pyrazol-4-yl)pyridin-2(1h)-one
  252. 4zo5: Pde10 Complexed with 4-isopropoxy-2-(2-(3-(4-methoxyphenyl)-4-oxo-3,4- Dihydroquinazolin-2-yl)ethyl)isoindoline-1,3-dione
  253. 4yqh: 2-[2-(4-phenyl-1h-imidazol-2-yl)ethyl]quinoxaline (sunovion Compound 14) Co-crystallized with PDE10A
  254. 4ys7: Co-crystal Structure of 2-[2-(5,8-dimethyl[1,2,4]triazolo[1,5- A]pyrazin-2-yl)ethyl]-3-methyl-3h-imidazo[4,5-f]quinoline (compound 39) with PDE10A
  255. 4xy2: Crystal Structure of PDE10A in Complex with Asp9436
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