EC 3.1.4.35 - 3',5'- cyclic- GMP 5'- nucleotidohydrolase (3',5'- cyclic- GMP phosphodiesterase)

3D structures of EC 3.1.4.35 - 3',5'-cyclic-GMP phosphodiesterase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1fqj: Crystal Structure of The Heterotrimeric Complex of The Rgs Domain of Rgs9, The Gamma Subunit of Phosphodiesterase and The Gt/i1 Chimera Alpha Subunit [(rgs9)-(pdegamma)- (GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)]
2. 1mc0: Regulatory Segment of Mouse 3',5'-cyclic Nucleotide Phosphodiesterase 2a, Containing The Gaf a and Gaf B Domains
3. 3mf0: Crystal Structure of PDE5A Gaf Domain (89-518)
4. 3lxg: Crystal Structure of Rat Phosphodiesterase 10a in Complex with Ligand Web-3
5. 3lfv: Crystal Structure of Unliganded PDE5A Gaf Domain
6. 3k3h: Crystal Structure of The PDE9A Catalytic Domain in Complex with (s)-bay73-6691
7. 3k3e: Crystal Structure of The PDE9A Catalytic Domain in Complex with (r)-bay73-6691
8. 3jwr: Crystal Structure of Chimeric Pde5/pde6 Catalytic Domain Complexed with 3-isobutyl-1-methylxanthine (ibmx) and Pde6 Gamma-subunit Inhibitory Peptide 70-87.
9. 3jwq: Crystal Structure of Chimeric Pde5/pde6 Catalytic Domain Complexed with Sildenafil
10. 3jsw: Human Pde9 in Complex with Selective Inhibitor
11. 3jsi: Human Phosphodiesterase 9 in Complex with Inhibitor
12. 3hr1: Discovery of Novel Inhibitors of PDE10A
13. 3hqz: Discovery of Novel Inhibitors of PDE10A
14. 3hqy: Discovery of Novel Inhibitors of PDE10A
15. 3hqw: Discovery of Novel Inhibitors of PDE10A
16. 3hdz: Identification, Synthesis, and Sar of Amino Substituted Pyrido[3,2b]pryaziones as Potent and Selective Pde5 Inhibitors
17. 3hc8: Investigation of Aminopyridiopyrazinones as Pde5 Inhibitors: Evaluation of Modifications to The Central Ring System.
18. 3dys: Human Phosphodiestrase-5'gmp Complex (ep), Produced by Soaking with 20mm Cgmp+20 Mm Mncl2+20 Mm Mgcl2 for 2 Hours, and Flash-cooled to Liquid Nitrogen Temperature When Substrate Was Still Abudant.
19. 3dyq: Human Phosphodiestrase 9 (inhibited by Omitting Divalent Cation) in Complex with Cgmp
20. 3dyn: Human Phosphodiestrase 9 in Complex with Cgmp (zn Inhibited)
21. 3dyl: Human Phosphdiesterase 9 Substrate Complex (es Complex)
22. 3dy8: Human Phosphodiesterase 9 in Complex with Product 5'-gmp (e+p Complex)
23. 3dba: Crystal Structure of The Cgmp-bound Gaf a Domain from The Photoreceptor Phosphodiesterase 6c
24. 3bjc: Crystal Structure of The PDE5A Catalytic Domain in Complex with a Novel Inhibitor
25. 3b2r: Crystal Structure of PDE5A1 Catalytic Domain in Complex with Vardenafil
26. 2yy2: Crystal Structure of The Human Phosphodiesterase 9a Catalytic Domain Complexed with Ibmx
27. 2wey: Human Pde-papaverine Complex Obtained by Ligand Soaking of Cross-linked Protein Crystals
28. 7jsn: Structure of The Visual Signaling Complex between Transducin and Phosphodiesterase 6
29. 2chm: Crystal Structure of N2 Substituted Pyrazolo Pyrimidinones- a Flipped Binding Mode in Pde5
30. 6acb: Crystal Structure of Pde5 in Complex with Inhibitor Lw1805
31. 6a3n: Crystal Structure of The Pde9 Catalytic Domain in Complex with Inhibitor 2
32. 5zz2: Crystal Structure of Pde5 in Complex with Inhibitor Lw1634
33. 5znl: Crystal Structure of PDE10A Catalytic Domain Complexed with Lhb-6
34. 2h40: Crystal Structure of The Catalytic Domain of Unliganded Pde5
35. 2h42: Crystal Structure of Pde5 in Complex with Sildenafil
36. 2h44: Crystal Structure of PDE5A1 in Complex with Icarisid II
37. 6x88: Pde6 Chicken Gaf Domain
38. 2k31: Solution Structure of Cgmp-binding Gaf Domain of Phosphodiesterase 5
39. 6l6e: Human Pde5 Catalytic Core in Complex with Avanafil
40. 6kze: The Crystal Structue of PDE10A Complexed with 4d
41. 3n3z: Crystal Structure of PDE9A (E406A) Mutant in Complex with Ibmx
42. 3qi3: Crystal Structure of PDE9A(Q453E) in Complex with Inhibitor Bay73-6691
43. 3qi4: Crystal Structure of PDE9A(Q453E) in Complex with Ibmx
44. 2xss: Crystal Structure of Gafb from The Human Phosphodiesterase 5
45. 6ko1: The Crystal Structue of PDE10A Complexed with 2d
46. 6ko0: The Crystal Structue of PDE10A Complexed with 1i
47. 3qpn: Structure of Pde10-inhibitor Complex
48. 3qpo: Structure of Pde10-inhibitor Complex
49. 3qpp: Structure of Pde10-inhibitor Complex
50. 3shy: Crystal Structure of The PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
51. 3shz: Crystal Structure of The PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
52. 3sie: Crystal Structure of The PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
53. 6iwi: Crystal Structure of PDE5A in Complex with a Novel Inhibitor
54. 3sn7: Highly Potent, Selective, and Orally Active Phosphodiestarase 10a Inhibitors
55. 3sni: Highly Potent, Selective, and Orally Active Phosphodiestarase 10a Inhibitors
56. 3snl: Highly Potent, Selective, and Orally Active Phosphodiestarase 10a Inhibitors
57. 3tge: A Novel Series of Potent and Selective Pde5 Inhibitor1
58. 3ui7: Discovery of Orally Active Pyrazoloquinoline as a Potent Pde10 Inhibitor for The Management of Schizophrenia
59. 3tgg: A Novel Series of Potent and Selective Pde5 Inhibitor2
60. 3uuo: The Discovery of Potent, Selectivity, and Orally Bioavailable Pyrozoloquinolines as Pde10 Inhibitors for The Treatment of Schizophrenia
61. 4ael: PDE10A in Complex with The Inhibitor Az5
62. 4dff: The Sar Development of Dihydroimidazoisoquinoline Derivatives as Phosphodiesterase 10a Inhibitors for The Treatment of Schizophrenia
63. 4ddl: PDE10A Crystal Structure Complexed with Novel Inhibitor
64. 6mzb: Cryo-em Structure of Phosphodiesterase 6
65. 6msc: Novel, Potent, Selective and Brain Penetrant Phosphodiesterase 10a Inhibitors
66. 6msa: Novel, Potent, Selective and Brain Penetrant Phosphodiesterase 10a Inhibitors
67. 6ke0: Crystal Structure of PDE10A in Complex with a Triazolopyrimidine Inhibitor
68. 6kdz: Crystal Structure of PDE10A in Complex with a Triazolopyrimidine Inhibitor
69. 6kdx: Crystal Structure of PDE10A in Complex with a Triazolopyrimidine Inhibitor
70. 6k9u: Discovery of Pyrazolo[1,5-a]pyrimidine Derivative as a Highly Selective PDE10A Inhibitor
71. 4fcb: Potent and Selective Phosphodiesterase 10a Inhibitors
72. 4fcd: Potent and Selective Phosphodiesterase 10a Inhibitors
73. 6iji: Crystal Structure of Pde10 in Complex with Inhibitor 2b
74. 6ijh: Crystal Structure of Pde10 in Complex with Inhibitor Af-399/14387019
75. 4gh6: Crystal Structure of The PDE9A Catalytic Domain in Complex with Inhibitor 28
76. 4heu: Crystal Structure of PDE10A with a Biaryl Ether Inhibitor ((1-(3-(4- ((1h-benzo[d]imidazol-2-yl)amino)phenoxy)pyridin-2-yl)piperidin-4- Yl)methanol)
77. 4hf4: Crystal Structure of PDE10A with a Biaryl Ether Inhibitor (1-(1-(3-(4- (benzo[d]thiazol-2-ylamino)phenoxy)pyrazin-2-yl)piperidin-4-yl) Ethanol)
78. 4e90: Human Phosphodiesterase 9 in Complex with Inhibitors
79. 4ajd: Identification and Structural Characterization of Pde10 Fragment Inhibitors
80. 4ajf: Identification and Structural Characterization of Pde10 Fragment Inhibitors
81. 4ajg: Identification and Structural Characterization of Pde10 Fragment Inhibitors
82. 4ajm: Development of a Plate-based Optical Biosensor Methodology to Identify Pde10 Fragment Inhibitors
83. 4g2j: Human Pde9 in Complex with Selective Compound
84. 4g2l: Human Pde9 in Complex with Selective Compound
85. 4g2w: Crystal Structure of PDE5A in Complex with Its Inhibitor
86. 3wi2: Crystal Structure of PDE10A in Complex with Inhibitor
87. 3ws8: Crystal Structure of PDE10A in Complex with a Benzimidazole Inhibitor
88. 3ws9: Crystal Structure of PDE10A in Complex with a Benzimdazole Inhibitor
89. 3wyk: Crystal Structure of The Catalytic Domain of PDE10A Complexed with 3- (1-phenyl-1h-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin- 4(1h)-one
90. 3wyl: Crystal Structure of The Catalytic Domain of PDE10A Complexed with 5- Methoxy-3-(1-phenyl-1h-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl) Pyridazin-4(1h)-one
91. 3wym: Crystal Structure of The Catalytic Domain of PDE10A Complexed with 1- (2-fluoro-4-(1h-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1h- Pyrazol-5-yl)pyridazin-4(1h)-one
92. 4bbx: Discovery of a Potent, Selective and Orally Active PDE10A Inhibitor for The Treatment of Schizophrenia
93. 4i9z: Crystal Structure of The PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
94. 4ia0: Crystal Structure of The PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
95. 4lkq: Crystal Structure of PDE10A2 with Fragment Zt017
96. 4llj: Crystal Structure of PDE10A2 with Fragment Zt214
97. 4llk: Crystal Structure of PDE10A2 with Fragment Zt217
98. 4llp: Crystal Structure of PDE10A2 with Fragment Zt401
99. 4llx: Crystal Structure of PDE10A2 with Fragment Zt434
100. 4lm0: Crystal Structure of PDE10A2 with Fragment Zt448
101. 4lm1: Crystal Structure of PDE10A2 with Fragment Zt450
102. 4lm2: Crystal Structure of PDE10A2 with Fragment Zt462
103. 4lm3: Crystal Structure of PDE10A2 with Fragment Zt464
104. 4lm4: Crystal Structure of PDE10A2 with Fragment Zt902
105. 4md6: Crystal Structure of Pde5 in Complex with Inhibitor 5r
106. 4mrw: Crystal Structure of PDE10A2 with Fragment Zt0120 (7-chloroquinolin-4- Ol)
107. 4mrz: Crystal Structure of PDE10A2 with Fragment Zt0429 (4-methyl-3- Nitropyridin-2-amine)
108. 4ms0: Crystal Structure of PDE10A2 with Fragment Zt0443 (6-chloropyrimidine- 2,4-diamine)
109. 4msa: Crystal Structure of PDE10A2 with Fragment Zt0449 (5-nitro-1h- Benzimidazole)
110. 4msc: Crystal Structure of PDE10A2 with Fragment Zt1595 (2-[(quinolin-7- Yloxy)methyl]quinoline)
111. 4mse: Crystal Structure of PDE10A2 with Fragment Zt1597 (2-({[(2s)-2-methyl- 2,3-dihydro-1,3-benzothiazol-5-yl]oxy}methyl)quinoline)
112. 4msh: Crystal Structure of PDE10A2 with Fragment Zt0143 ((2s)-4-chloro-2,3- Dihydro-1,3-benzothiazol-2-amine)
113. 4msn: Crystal Structure of PDE10A2 with Fragment Zt0451 (8-nitroquinoline)
114. 4muw: Crystal Structure of PDE10A with Novel Keto-benzimidazole Inhibitor
115. 4mvh: Crystal Structure of PDE10A with Novel Keto-benzimidazole Inhibitor
116. 4p0n: Crystal Structure of PDE10A with a Novel Imidazo[4,5-b]pyridine Inhibitor
117. 4p1r: Crystal Structure of PDE10A with Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors
118. 4phw: Crystal Structure of PDE10A with 1h-benzimidazol-2-yl(4-((3- (tetrahydro-2h-pyran-4-yl)-2-pyridinyl)oxy)phenyl)methanone
119. 5xuj: Crystal Structure of PDE10A in Complex with 7-(4-chlorophenyl)-2- Methylpyrazolo[1,5-a]pyrimidine
120. 5xui: Crystal Structure of PDE10A in Complex with 2-methyl-5-[2-([1,2, 4]triazolo[1,5-a]pyrimidin-2-yl)et Hyl]pyrazolo[1,5-a]pyrimidin-7-ol
121. 5uwf: Crystal Structure of Human PDE10A in Complex with Inhibitor 16d
122. 5k9r: PDE10A with Imidazopyrazine Inhibitor
123. 5jo3: PDE5A for Nav1.7
124. 5i2r: Human PDE10A in Complex with 3-(2-phenylpyrazol-3-yl)-1-[3- (trifluoromethoxy)phenyl]pyridazin-4-one
125. 5edi: Human PDE10A, 6-chloro-5,8-dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl- 2h-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyridine, 2.20a, H3, Rfree=23.5%
126. 5edh: Human PDE10A, 8-ethyl-5-methyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4- Triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine, 2.03a, H3, Rfree=22.7%
127. 5edg: Human PDE10A in Complex with 3-(2-chloro-5-phenyl-3h-imidazol-4-yl)-1- (3-trifluoromethoxy-phenyl)-1h-pyridazin-4-one at 2.30a
128. 5ede: Human PDE10A in Complex with 1-(4-chloro-phenyl)-3-methyl-1h-thieno[2, 3-c]pyrazole-5-carboxylic Acid (tetrahydro-furan-2-ylmethyl)-amide at 2.2a
129. 5e8f: Structure of Fully Modified Geranylgeranylated PDE6C Peptide in Complex with PDE6D
130. 5dh5: Pde10 Complexed with N-[(1-methylpyrazol-4-yl)methyl]-5-[[(1s,2s)-2- (2-pyridyl)cyclopropyl]methoxy]pyrazolo[1,5-a]pyrimidin-7-amine
131. 5dh4: Pde10 Complexed with 5-chloro-n-[(2,4-dimethylthiazol-5-yl) Methyl]pyrazolo[1,5-a]pyrimidin-7-amine
132. 5c2h: Pde10 Complexed with 6-chloro-n-[(2,4-dimethylthiazol-5-yl)methyl]-5- Methyl-2-[3-(2-quinolyl)propoxy]pyrimidin-4-amine
133. 5c2e: Pde10 Complexed With6-chloro-n-[(2,4-dimethylthiazol-5-yl)methyl]-5- Methyl-2-[2-(2-pyridyl)ethoxy]pyrimidin-4-amine
134. 5c2a: Pde10 Complexed with 6-chloro-2-cyclopropyl-n-[(2,4-dimethylthiazol-5- Yl)methyl]-5-methyl-pyrimidin-4-amine
135. 5c29: Pde10 Complexed with 6-chloro-2-cyclopropyl-5-methyl-n-propyl- Pyrimidin-4-amine
136. 5c28: Pde10 Complexed with 6-chloro-2-cyclopropyl-5-methyl-pyrimidin-4-amine
137. 5c1w: Pde10 Complexed with 4,6-dichloro-2-cyclopropyl-5-methyl-pyrimidine
138. 4tpm: Crystal Structure of 2-(3-alkoxy-1-azetidinyl) Quinolines as PDE10A Inhibitors
139. 4tpp: 2-(3-alkoxy-1-azetidinyl) Quinolines as Novel PDE10A Inhibitors
140. 5axq: Crystal Structure of The Catalytic Domain of PDE10A Complexed with Highly Potent and Brain-penetrant PDE10A Inhibitor with 2-oxindole Scaffold
141. 5axp: Crystal Structure of The Catalytic Domain of PDE10A Complexed with 1- (2-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl)-5-methoxy-3-(1-phenyl- 1h-pyrazol-5-yl)pyridazin-4(1h)-one
142. 4wn1: Crystal Structure of PDE10A in Complex with 1-methyl-5-(1-methyl-3- {[4-(quinolin-2-yl)phenoxy]methyl}-1h-pyrazol-4-yl)pyridin-2(1h)-one
143. 4zo5: Pde10 Complexed with 4-isopropoxy-2-(2-(3-(4-methoxyphenyl)-4-oxo-3,4- Dihydroquinazolin-2-yl)ethyl)isoindoline-1,3-dione
144. 4oew: Crystal Structure of The PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
145. 4oex: Crystal Structure of The PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
146. 4yqh: 2-[2-(4-phenyl-1h-imidazol-2-yl)ethyl]quinoxaline (sunovion Compound 14) Co-crystallized with PDE10A
147. 4ys7: Co-crystal Structure of 2-[2-(5,8-dimethyl[1,2,4]triazolo[1,5- A]pyrazin-2-yl)ethyl]-3-methyl-3h-imidazo[4,5-f]quinoline (compound 39) with PDE10A
148. 4xy2: Crystal Structure of PDE10A in Complex with Asp9436
149. 4y86: Crystal Structure of Pde9 in Complex with Racemic Inhibitor C33
150. 4y87: Crystal Structure of Phosphodiesterase 9 in Complex with (r)-c33 (6- {[(1r)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4h- Pyrazolo[3,4-d]pyrimidin-4-one)
151. 4y8c: Crystal Structure of Phosphodiesterase 9 in Complex with (s)-c33
152. 6vbi: Crystal Structure of Pde5 in Complex with a Non-competitive Inhibitor
153. 7bpi: The Crystal Structue of PDE10A Complexed with 14
154. 6lzz: Crystal Structure of The Pde9 Catalytic Domain in Complex with Inhibitor 4a