EC 3.4.22.36 - caspase- 1

3D structures of EC 3.4.22.36 - caspase-1 in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1bmq: Crystal Structure of The Complex of Interleukin-1beta Converting Enzyme (ice) with a Peptide Based Inhibitor, (3s )-n-methanesulfonyl-3-({1-[n-(2-naphtoyl)-l-valyl]-l- Prolyl }amino)-4-oxobutanamide
2. 1ibc: Crystal Structure of Inhibited Interleukin-1beta Converting Enzyme
3. 1ice: Structure and Mechanism of Interleukin-1beta Converting Enzyme
4. 1m72: Crystal Structure of Caspase-1 from Spodoptera Frugiperda
5. 1rwk: Crystal Structure of Human Caspase-1 in Complex with 3-(2- Mercapto-acetylamino)-4-oxo-pentanoic Acid
6. 1rwm: Crystal Structure of Human Caspase-1 in Complex with 4-oxo- 3-[2-(5-{[4-(quinoxalin-2-ylamino)-benzoylamino]-methyl}- Thiophen-2-yl)-acetylamino]-pentanoic Acid
7. 1rwn: Crystal Structure of Human Caspase-1 in Complex with 3-{2- Ethyl-6-[4-(quinoxalin-2-ylamino)-benzoylamino]- Hexanoylamino}-4-oxo-butyric Acid
8. 1rwo: Crystal Structure of Human Caspase-1 in Complex with 4-oxo- 3-{6-[4-(quinoxalin-2-ylamino)-benzoylamino]-2-thiophen-2- Yl-hexanoylamino}-pentanoic Acid
9. 1rwp: Crystal Structure of Human Caspase-1 in Complex with 3-{6- [(8-hydroxy-quinoline-2-carbonyl)-amino]-2-thiophen-2-yl- Hexanoylamino}-4-oxo-butyric Acid
10. 1rwv: Crystal Structure of Human Caspase-1 in Complex with 5-[5- (1-carboxymethyl-2-oxo-propylcarbamoyl)-5-phenyl- Pentylsulfamoyl]-2-hydroxy-benzoic Acid
11. 1rww: Crystal Structure of Human Caspase-1 in Complex with 4-oxo- 3-[(6-{[4-(quinoxalin-2-ylamino)-benzoylamino]-methyl}- Pyridine-3-carbonyl)-amino]-butyric Acid
12. 1rwx: Crystal Structure of Human Caspase-1 in Complex with 4-oxo- 3-{6-[4-(quinoxalin-2-yloxy)-benzoylamino]-2-thiophen-2-yl- Hexanoylamino}-butyric Acid
13. 1sc1: Crystal Structure of an Active-site Ligand-free Form of The Human Caspase-1 C285A Mutant
14. 1sc3: Crystal Structure of The Human Caspase-1 C285A Mutant in Complex with Malonate
15. 1sc4: Crystal Structure of The Human Caspase-1 C285A Mutant after Removal of Malonate
16. 3e4c: Procaspase-1 Zymogen Domain Crystal Strucutre
17. 3d6m: Crystal Structure of Human Caspase-1 with a Naturally- Occurring Lys319->arg Substitution in Complex with 3-[2-(2- Benzyloxycarbonylamino-3-methyl-butyrylamino)- Propionylamino]-4-oxo-pentanoic Acid (z-vad-fmk)
18. 3d6h: Crystal Structure of Human Caspase-1 with a Naturally- Occurring Asn263->ser Substitution in Complex with 3-[2-(2- Benzyloxycarbonylamino-3-methyl-butyrylamino)- Propionylamino]-4-oxo-pentanoic Acid (z-vad-fmk)
19. 3d6f: Crystal Structure of Human Caspase-1 with a Naturally- Occurring Arg240->gln Substitution in Complex with 3-[2-(2- Benzyloxycarbonylamino-3-methyl-butyrylamino)- Propionylamino]-4-oxo-pentanoic Acid (z-vad-fmk)
20. 7keu: Cryo-em Structure of The Caspase-1-card:asc-card Octamer
21. 6bz9: Crystal Structure of Human Caspase-1 in Complex with Ac-fltd-cmk
22. 2nn3: Structure of Pro-sf-caspase-1
23. 2fqq: Crystal Structure of Human Caspase-1 (cys285->ala, Cys362- >ala, Cys364->ala, Cys397->ala) in Complex with 1-methyl-3- Trifluoromethyl-1h-thieno[2,3-c]pyrazole-5-carboxylic Acid (2-mercapto-ethyl)-amide
24. 2h48: Crystal Structure of Human Caspase-1 (cys362->ala, Cys364- >ala, Cys397->ala) in Complex with 3-[2-(2- Benzyloxycarbonylamino-3-methyl-butyrylamino)- Propionylamino]-4-oxo-pentanoic Acid (z-vad-fmk)
25. 2h4w: Crystal Structure of Human Caspase-1 (glu390->asp) in Complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl- Butyrylamino)-propionylamino]-4-oxo-pentanoic Acid (z-vad- Fmk)
26. 2h4y: Crystal Structure of Human Caspase-1 (arg286->lys) in Complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl- Butyrylamino)-propionylamino]-4-oxo-pentanoic Acid (z-vad- Fmk)
27. 2h51: Crystal Structure of Human Caspase-1 (glu390->asp and Arg286->lys) in Complex with 3-[2-(2- Benzyloxycarbonylamino-3-methyl-butyrylamino)- Propionylamino]-4-oxo-pentanoic Acid (z-vad-fmk)
28. 2h54: Crystal Structure of Human Caspase-1 (thr388->ala) in Complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl- Butyrylamino)-propionylamino]-4-oxo-pentanoic Acid (z-vad- Fmk)
29. 2hbq: Crystal Structure of Wildtype Human Caspase-1 in Complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)- Propionylamino]-4-oxo-pentanoic Acid (z-vad-fmk)
30. 2hbr: Crystal Structure of Human Caspase-1 (arg286->ala) in Complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl- Butyrylamino)-propionylamino]-4-oxo-pentanoic Acid (z-vad- Fmk)
31. 2hby: Crystal Structure of Human Caspase-1 (glu390->ala) in Complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl- Butyrylamino)-propionylamino]-4-oxo-pentanoic Acid (z-vad- Fmk)
32. 2hbz: Crystal Structure of Human Caspase-1 (arg286->ala, Glu390- >ala) in Complex with 3-[2-(2-benzyloxycarbonylamino-3- Methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic Acid (z-vad-fmk)
33. 6vie: Structure of Caspase-1 in Complex with Gasdermin D
34. 6pzp: Crystal Structure of Caspase-1 in Complex with Vx-765
35. 3ns7: Succinic Acid Amides as P2-p3 Replacements for Inhibitors of Interleukin-1beta Converting Enzyme (ice or Caspase 1)
36. 6f6r: Crystal Structure of Human Caspase-1 with N-{3-[1-((s)-2-hydroxy-5- Oxo-tetrahydro-furan-3-ylcarbamoyl)-ethyl]-1-methyl-2,4-dioxo-1,2,3, 4-tetrahydro-pyrimidin-5-yl}-4-(quinoxalin-2-ylamino)-benzamide
37. 6kn0: Caspase-1 P20/p10 C285A in Complex with Human Gsdmd-c Domain
38. 5mtk: Crystal Structure of Human Caspase-1 with (3s,6s,10as)-n-((2s,3s)-2- Hydroxy-5-oxotetrahydrofuran-3-yl)-6-(isoquinoline-1-carboxamido)-5- Oxodecahydropyrrolo[1,2-a]azocine-3-carboxamide (pge-3935199)
39. 5mmv: Crystal Structure of Human Caspase-1 with 2-((2-naphthoyl)-l-valyl)-4- Hydroxy-n-((3s)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-2- Azabicyclo[2.2.2]octane-3-carboxamide (compound 1)
40. 5fna: Cryo-em Reconstruction of Caspase-1 Card