EC 2.4.2.12 - nicotinamide- nucleotide:diphosphate phospho- β- D- ribosyltransferase (nicotinamide phosphoribosyltransferase)

3D structures of EC 2.4.2.12 - nicotinamide phosphoribosyltransferase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 3g8e: Crystal Structure of Rattus Norvegicus Visfatin/pbef/nampt in Complex with an Fk866-based Inhibitor
2. 3dkl: Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Benzamide and Phosphoribosyl Pyrophosphate
3. 3dkj: Crystal Structure of Human Nampt Complexed with Benzamide and Phosphoribosyl Pyrophosphate
4. 3dhf: Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate
5. 3dhd: Crystal Structure of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate
6. 3dgr: Crystal Structure of Human Nampt Complexed with Adp Analogue
7. 6b76: Crystal Structure of Human Nampt in Complex with Nvp-lvr596
8. 6b75: Crystal Structure of Human Nampt in Complex with Nvp-loq594
9. 2e5b: Crystal Structure of Human Nmprtase as Free-form
10. 2e5c: Crystal Structure of Human Nmprtase Complexed with 5'- Phosphoribosyl-1'-pyrophosphate
11. 2e5d: Crystal Structure of Human Nmprtase Complexed with Nicotinamide
12. 6azj: Crystal Structure of Human Nampt in Complex with Nvp-lqn520
13. 6atb: Crystal Structure of Human Nampt in Complex with Nvp-lod812
14. 2g95: Crystal Structure of Visfatin/pre-b Cell Colony Enhancing Factor 1/nicotinamide Phosphoribosyltransferase
15. 2g96: Crystal Structure of Visfatin/pre-b Cell Colony Enhancing Factor 1/nicotinamide Phosphoribosyltransferase in Complex with Niconamide Mononucleotide
16. 2g97: Crystal Structure of Visfatin/pre-b Cell Colony Enhancing Factor 1/nicotinamide Phosphoribosyltransferase in Complex with The Specific Inhibitor Fk-866
17. 2gvg: Crystal Structure of Human Nmprtase and Its Complex with Nmn
18. 2gvj: Crystal Structure of Human Nmprtase in Complex with Fk866
19. 2gvl: Crystal Structure of Murine Nmprtase
20. 2h3b: Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/visfatin/pre-b Cell Colony Enhancing Factor 1
21. 2h3d: Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/visfatin/pre-b Cell Colony Enhancing Factor in Complex with Nicotinamide Mononuleotide
22. 6tac: Human Nampt Deletion Mutant in Complex with Nicotinamide Mononucleotide, Pyrophosphate, and Mg2+
23. 6ta2: Human Nampt in Complex with Nicotinic Acid Mononucleotide and Phosphate
24. 6ta0: Human Nampt in Complex with Nicotinic Acid and Phosphoribosyl Pyrophosphate
25. 6peb: Crystal Structure of Human Nampt in Complex with Nvp-ltm976
26. 4jr5: Structure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (nampt) Inhibitors
27. 4kfn: Structure-based Discovery of Novel Amide-containing Nicotinamide Phosphoribosyltransferase (nampt) Inhibitors
28. 4kfo: Structure-based Discovery of Novel Amide-containing Nicotinamide Phosphoribosyltransferase (nampt) Inhibitors
29. 4jnm: Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (nampt) Inhibitors with Reduced CYP2C9 Inhibition Properties
30. 6e68: Nampt Co-crystal with Inhibitor Compound 2
31. 4kfp: Identification of 2,3-dihydro-1h-pyrrolo[3,4-c]pyridine-derived Ureas as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (nampt)
32. 4l4l: Structural Analysis of a Phosphoribosylated Inhibitor in Complex with Human Nicotinamide Phosphoribosyltransferase
33. 4l4m: Structural Analysis of a Phosphoribosylated Inhibitor in Complex with Human Nicotinamide Phosphoribosyltransferase
34. 4lts: Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (nampt) Inhibitors
35. 4lv9: Fragment-based Identification of Amides Derived from Trans-2-(pyridin- 3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (nampt)
36. 4lva: Fragment-based Identification of Amides Derived from Trans-2-(pyridin- 3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (nampt)
37. 4lvb: Fragment-based Identification of Amides Derived from Trans-2-(pyridin- 3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (nampt)
38. 4lvd: Fragment-based Identification of Amides Derived from Trans-2-(pyridin- 3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (nampt)
39. 4lvf: Fragment-based Identification of Amides Derived from Trans-2-(pyridin- 3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (nampt)
40. 4lvg: Fragment-based Identification of Amides Derived from Trans-2-(pyridin- 3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (nampt)
41. 4lww: Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (nampt) Inhibitors
42. 4m6p: Identification of Amides Derived from 1h-pyrazolo[3,4-b]pyridine-5- Carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (nampt)
43. 4m6q: Identification of Amides Derived from 1h-pyrazolo[3,4-b]pyridine-5- Carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (nampt)
44. 4n9b: Fragment-based Design of 3-aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (nampt)
45. 4n9c: Fragment-based Design of 3-aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (nampt)
46. 4n9d: Fragment-based Design of 3-aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (nampt)
47. 4n9e: Fragment-based Design of 3-aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (nampt)
48. 4o0z: Structural and Biochemical Analyses of The Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase
49. 4o10: Structural and Biochemical Analyses of The Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase
50. 4o12: Structural and Biochemical Analyses of The Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase
51. 4o13: The Crystal Structure of Nampt in Complex with Gne-618
52. 4o14: Structural Basis for Resistance to Diverse Classes of Nampt Inhibitors
53. 4o15: The Crystal Structure of a Mutant Nampt (S165F) in Complex with Gne- 618
54. 4o16: Structural Basis for Resistance to Diverse Classes of Nampt Inhibitors
55. 4o17: Structural Basis for Resistance to Diverse Classes of Nampt Inhibitors
56. 4o18: Structural Basis for Resistance to Diverse Classes of Nampt Inhibitors
57. 4o19: The Crystal Structure of a Mutant Nampt (G217V)
58. 4o1a: The Crystal Structure of The Mutant Nampt G217R
59. 4o1b: The Crystal Structure of a Mutant Nampt (G217R) in Complex with an Inhibitor Apo866
60. 4o1c: The Crystal Structures of a Mutant Nampt H191R
61. 4o1d: Structural Basis for Resistance to Diverse Classes of Nampt Inhibitors
62. 4o28: Structural Basis for Resistance to Diverse Classes of Nampt Inhibitors
63. 5wi1: Crystal Structure of Human Nampt with Fragment 5: (3e)-3- [(phenylamino)methylidene]oxan-2-one
64. 5wi0: Crystal Structure of Human Nampt with Fragment 2: 2-[(2-fluorophenyl) Amino]-6-propylpyrimidin-4(3h)-one
65. 5upf: Crystal Structure of Human Nampt with Isoindoline Urea Inhibitor Compound 53
66. 5upe: Crystal Structure of Human Nampt with Isoindoline Urea Inhibitor Compound 5
67. 5u2n: Crystal Structure of Human Nampt with A-1326133
68. 5u2m: Crystal Structure of Human Nampt with A-1293201
69. 5nsd: Co-crystal Structure of Nampt Dimer with Kpt-9274
70. 5lx5: Crystal Structure of Visfatin in Complex with Sar154782-rp.
71. 5lx3: Crystal Structure of Visfatin in Complex with Sar154782.
72. 5kit: Crystal Structure of Nicotinamide Phosphoribosyltransferase (nampt) in Complex with Inhibitors 37
73. 4wq6: The Crystal Structure of Human Nicotinamide Phosphoribosyltransferase (nampt) in Complex with N-(4-{(s)-[1-(2-methylpropyl)piperidin-4- Yl]sulfinyl}benzyl)furo[2,3-c]pyridine-2-carboxamide Inhibitor (compound 21)
74. 7q8t: Crystal Structure of Nampt Bound to Ligand Tsy535(compound 9a)