EC 2.4.2.8 - IMP:diphosphate phospho- D- ribosyltransferase (hypoxanthine phosphoribosyltransferase)

3D structures of EC 2.4.2.8 - hypoxanthine phosphoribosyltransferase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1bzy: Human Hgprtase with Transition State Inhibitor
2. 1cjb: Malarial Purine Phosphoribosyltransferase
3. 1d6n: Ternary Complex Structure of Human Hgprtase, Prpp, Mg2+, and The Inhibitor Hpp Reveals The Involvement of The Flexible Loop in Substrate Binding
4. 1dqn: Crystal Structure of Giardia Guanine Phosphoribosyltransferase Complexed with a Transition State Analogue
5. 1dqp: Crystal Structure of Giardia Guanine Phosphoribosyltransferase Complexed with Immucilling
6. 1fsg: Toxoplasma Gondii Hypoxanthine-guanine Phosphoribosyltransferase Complexed with 9-deazaguanine, Alpha-d-5-phosphoribosyl-1-pyrophosphate (prpp) and Two Mg2+ Ions
7. 1g9s: Crystal Structure of a Complex between E.coli Hprt and Imp
8. 1g9t: Crystal Structure of E.coli Hprt-gmp Complex
9. 1grv: Hypoxanthine Phosphoribosyltransferase from E. Coli
10. 1hgx: Hypoxanthine-guanine-xanthine Phosphoribosyltransferase (hgxprtase)
11. 1hmp: The Crystal Structure of Human Hypoxanthine-guanine Phosphoribosyltransferase with Bound Gmp
12. 1i0i: Analysis of an Invariant Aspartic Acid in Hprts-glutamine Mutant
13. 1i0l: Analysis of an Invariant Aspartic Acid in Hprts-asparagine Mutant
14. 1i13: Analysis of an Invariant Aspartic Acid in Hprts-alanine Mutant
15. 1i14: Analysis of an Invariant Aspartic Acid in Hprts-glutamic Acid Mutant
16. 1j7j: Crystal Structure of The Hprt from Salmonella Typhimurium
17. 3ohp: Crystal Structure of Hgprt from Vibrio Cholerae
18. 3o7m: 1.98 Angstrom Resolution Crystal Structure of a Hypoxanthine-guanine Phosphoribosyltransferase (hpt-2) from Bacillus Anthracis Str. 'ames Ancestor'
19. 3kb8: 2.09 Angstrom Resolution Structure of a Hypoxanthine-guanine Phosphoribosyltransferase (hpt-1) from Bacillus Anthracis Str. 'ames Ancestor' in Complex with Gmp
20. 1p17: Hypoxanthine Phosphoribosyltransferase from Trypanosoma Cruzi, K68R Mutant, Complexed with The Product Imp
21. 1p18: Hypoxanthine Phosphoribosyltransferase from Trypanosoma Cruzi, K68R Mutant, Ternary Substrates Complex
22. 1p19: Hypoxanthine Phosphoribosyltransferase from Trypanosoma Cruzi, in Complex with The Product Imp
23. 1pzm: Crystal Structure of Hgprt-ase from Leishmania Tarentolae in Complex with Gmp
24. 1qk3: Toxoplasma Gondii Hypoxanthine-guanine Phosphoribosyltransferase Gmp Complex
25. 1qk4: Toxoplasma Gondii Hypoxanthine-guanine Phosphoribosyltransferase Imp Complex
26. 1qk5: Toxoplasma Gondii Hypoxanthine-guanine Phosphoribosyltransferase with Xmp, Pyrophosphate and Two Mg2+ Ions
27. 1r3u: Crystal Structure of Hypoxanthine-guanine Phosphoribosyltransferase from Thermoanaerobacter Tengcongensis
28. 3ggj: Human Hypoxanthine-guanine Phosphoribosyltransferase in Complex with 9-(2-phosphonoethoxyethyl)guanine
29. 3ggc: Human Hypoxanthine-guanine Phosphoribosyltransferase in Complex with 9-(2-phosphonoethoxyethyl)hypoxanthine
30. 3gep: Human Hypoxanthine Guanine Phosphoribosyltranserfase in Complex with (s)-9-(3-hydroxy-2-phosphonylmethoxypropyl) Guanine
31. 1tc1: A 1.4 Angstrom Crystal Structure for The Hypoxanthine Phosphoribosyltransferase of Trypanosoma Cruzi
32. 1tc2: Ternary Substrate Complex of The Hypoxanthine Phosphoribosyltransferase from Trypanosoma Cruzi
33. 3acd: Crystal Structure of Hypoxanthine-guanine Phosphoribosyltransferase with Imp from Thermus Thermophilus Hb8
34. 3acc: Crystal Structure of Hypoxanthine-guanine Phosphoribosyltransferase with Gmp from Thermus Thermophilus Hb8
35. 3acb: Crystal Structure of Hypoxanthine-guanine Phosphoribosyltransferase from Thermus Thermophilus Hb8
36. 1yfz: Novel Imp Binding in Feedback Inhibition of Hypoxanthine- Guanine Phosphoribosyltransferase from Thermoanaerobacter Tengcongensis
37. 1z7g: Free Human Hgprt
38. 2vfa: Crystal Structure of a Chimera of Plasmodium Falciparum and Human Hypoxanthine-guanine Phosphoribosyl Transferases
39. 6bo7: Crystal Structure of Plasmodium Vivax Hypoxanthine Guanine Phosphoribosyltransferase in Complex with [3r,4r]-4-guanin-9-yl-3- ((s)-2-hydroxy-2-phosphonoethyl)oxy-1-n-(phosphonopropionyl) Pyrrolidine
40. 6bnj: Human Hypoxanthine Guanine Phosphoribosyltransferase in Complex with [3r,4r]-4-guanin-9-yl-3-((r)-2-hydroxy-2-phosphonoethyl)oxy-1-n- (phosphonopropionyl)pyrrolidine
41. 6apv: Trypanosoma Brucei Hypoxanthine Guanine Phosphoribosyltransferase in Complex with [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9h-purin-9-yl) Ethyl][(e)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic Acid
42. 6apu: Crystal Structure of Trypanosoma Brucei Hypoxanthine-guanine Phosphoribosyltranferase in Complex with (2-{[2-(2-amino-6-oxo-1,6- Dihydro-9h-purin-9-yl)ethyl](3-aminopropyl)amino}ethyl)phosphonic Acid
43. 6apt: Trypanosoma Brucei Hypoxanthine Guanine Phosphoribosyltransferase in Complex with {[(2s)-3-(2-amino-6-oxo-1,6-dihydro-9h-purin-9-yl) Propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic Acid)
44. 6aps: Trypanosoma Brucei Hypoxanthine Guanine Phosphoribosyltransferase in Complex with [(2-((guanine-9h-yl)methyl)propane-1,3 Diyl)bis(oxy) ]bis(methylene))diphosphonic Acid
45. 2geb: Crystal Structure of The Thermoanaerobacter Tengcongensis Hypoxanthine-guanine Phosphoribosyltransferase L160I Mutant: Insights into The Inhibitor Design
46. 2jbh: Human Phosphoribosyl Transferase Domain Containing 1
47. 2jky: Saccharomyces Cerevisiae Hypoxanthine-guanine Phosphoribosyltransferase in Complex with Gmp (guanosine 5' -monophosphate) (tetragonal Crystal Form)
48. 2jkz: Saccharomyces Cerevisiae Hypoxanthine-guanine Phosphoribosyltransferase in Complex with Gmp (guanosine 5' -monophosphate) (orthorhombic Crystal Form)
49. 2xbu: Saccharomyces Cerevisiae Hypoxanthine-guanine Phosphoribosyltransferase in Complex with Gmp (monoclinic Crystal Form)
50. 6mxg: Crystal Structure of Trypanosoma Brucei Hypoxanthine-guanine Phosphoribosyltranferase in Complex with Xmp
51. 6igs: Crystal Structure of Hprt from F. Tularensis with Zinc
52. 4ijq: Human Hypoxanthine-guanine Phosphoribosyltransferase in Complex with [(2-((guanine-9h-yl)methyl)propane-1,3-diyl)bis(oxy)]bis(methylene)) Diphosphonic Acid
53. 6d9s: The (p)ppgpp-bound Crystal Structure of Hprt (hypoxanthine Phosphoribosyltransferase)
54. 6d9r: The Substrate-bound Crystal Structure of Hprt (hypoxanthine Phosphoribosyltransferase)
55. 6d9q: The Sulfate-bound Crystal Structure of Hprt (hypoxanthine Phosphoribosyltransferase)
56. 4kn6: Crystal Structure of Human Hypoxanthine-guanine Phosphoribosyltransferase in Complex with 6-fluoro-3-hydroxy-2- Pyrazinecarboxamide (t-705) Ribose-5'-monophosphate
57. 4lyy: Crystal Structure of Hypoxanthine Phosphoribosyltransferase from Shewanella Pealeana Atcc 700345, Nysgrc Target 029677.
58. 4pfq: Crystal Structure of Hypoxanthine Phosphoribosyltransferase from Brachybacterium Faecium Dsm 4810, Nysgrc Target 029763.
59. 5w8v: Human Hgprt in Complex with [(2-[(guanin-9-yl)methyl]propane-1,3- Diyl)bis(oxy)]bis(methylene)diphosphonic Acid
60. 4qri: 2.35 Angstrom Resolution Crystal Structure of Hypoxanthine-guanine- Xanthine Phosphoribosyltransferase from Leptospira Interrogans Serovar Copenhageni Str. Fiocruz L1-130
61. 4qyi: 1.95 Angstrom Resolution Crystal Structure of a Hypoxanthine-guanine Phosphoribosyltransferase (hpt-2) from Bacillus Anthracis Str. 'ames Ancestor' with Hepes Molecule in The Active Site
62. 4rqa: Crystal Structure of a Hypoxanthine Phosphoribosyltransferase (target Id Nysgrc-029686) from Staphylococcus Aureus (orthorhombic Space Group)
63. 4rqb: Crystal Structure of a Hypoxanthine Phosphoribosyltransferase (target Id Nysgrc-029686) from Staphylococcus Aureus (tetragonal Space Group)
64. 5kny: Crystal Structure of Mycobacterium Tuberculosis Hypoxanthine Guanine Phosphoribosyltransferase in Complex with (3-((3r,4r)-3-(guanin-9- Yl)-4-((s)-2-hydroxy-2-phosphonoethoxy)pyrrolidin-1-yl)-3-oxopropyl) Phosphonic Acid
65. 5knq: Crystal Structure of Mycobacterium Tuberculosis Hypoxanthine Guanine Phosphoribosyltransferase in Complex with [3s,4r]-(4-(guanin-9-yl) Pyrrolidin-3-yl)oxymethanephosphonic Acid and Pyrophosphate
66. 5knp: Crystal Structure of Mycobacterium Tuberculosis Hypoxanthine Guanine Phosphoribosyltransferase in Complex with [3s,4r]-(4-(hypoxanthin-9- Yl)pyrrolidin-3-yl)-oxymethanephosphonic Acid
67. 5kap: Trypanosome Brucei Hypoxanthine-guanine Phosphoribosyltranferase in Complex with a 9-(4-(phosphonobutil)hypoxanthine
68. 5kam: Trypanosome Brucei Hypoxanthine-guanine Phosphoribosyltranferase in Complex with Inosine 5' Monophosphate
69. 5k51: Trypanosome Brucei Hypoxanthine-guanine Phosphoribosyltranferase in Complex with a 9-[5-(phosphonoheptyl]hypoxanthine
70. 5jv5: Trypanosome Brucei Hypoxanthine-guanine Phosphoribosyltranferase in Complex with Guanosine 5' Monophosphate
71. 5jsq: Trypanosome Brucei Hypoxanthine-guanine Phosphoribosyltranferase in Complex with a 9-[7-(phosphonoheptyl]guanine
72. 5ipf: Crystal Structure of Hypoxanthine-guanine Phosphoribosyltransferase from Schistosoma Mansoni in Complex with Imp
73. 5hia: Human Hypoxanthine-guanine Phosphoribosyltransferase in Complex with [3r,4r]-4-guanin-9-yl-3-((s)-2-hydroxy-2-phosphonoethyl)oxy-1-n- (phosphonopropionyl)pyrrolidine
74. 5esw: Crystal Structure of Apo Hypoxanthine-guanine Phosphoribosyltransferase from Legionella Pneumophila
75. 5bsk: Human Hgprt in Complex with (s)-hpepg, an Acyclic Nucleoside Phosphonate
76. 5brn: Human Hgprt in Complex with (s)-hpephx, an Acyclic Nucleoside Phosphonate
77. 5bqo: Hypoxanthine-guanine-xanthine Phosphoribosyltransferase (hgxprt) from Sulfolobus Solfataricus with Sulfate Bound in The 5-phosphoribosyl Binding Site.
78. 4rab: Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group as Inhibitors of The Human, Plasmodium Falciparum and Vivax 6- Oxopurine Phosphoribosyltransferases and Their Pro-drugs as Antimalarial Agents
79. 4rac: Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group as Inhibitors of The Human, Plasmodium Falciparum and Vivax 6- Oxopurine Phosphoribosyltransferases and Their Pro-drugs as Antimalarial Agents
80. 4rad: Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group as Inhibitors of The Human, Plasmodium Falciparum and Vivax 6- Oxopurine Phosphoribosyltransferases and Their Pro-drugs as Antimalarial Agents
81. 4ran: Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group as Inhibitors of The Human, Plasmodium Falciparum and Vivax 6- Oxopurine Phosphoribosyltransferases and Their Pro-drugs as Antimalarial Agents
82. 4rao: Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group as Inhibitors of The Human, Plasmodium Falciparum and Vivax 6- Oxopurine Phosphoribosyltransferases and Their Pro-drugs as Antimalarial Agents
83. 4raq: Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group as Inhibitors of The Human, Plasmodium Falciparum and Vivax 6- Oxopurine Phosphoribosyltransferases and Their Pro-drugs as Antimalarial Agents
84. 4z1o: Hypoxanthine-guanine-xanthine Phosphoribosyltransferase (hgxprt) from Sulfolobus Solfataricus in Complex with Alpha- Phosphoribosylpyrophosphoric Acid (prpp) and Magnesium
85. 7cmj: Crystal Structure of L.donovani Hypoxanthine-guanine Phosphoribosyl Transferase (hgprt)