EC 3.4.21.21 - coagulation factor VIIa

3D structures of EC 3.4.21.21 - coagulation factor VIIa in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1bf9: N-terminal Egf-like Domain from Human Factor Vii, Nmr, 23 Structures
2. 1cvw: Crystal Structure of Active Site-inhibited Human Coagulation Factor Viia (des-gla)
3. 1dan: Complex of Active Site Inhibited Human Blood Coagulation Factor Viia with Human Recombinant Soluble Tissue Factor
4. 1dva: Crystal Structure of The Complex between The Peptide Exosite Inhibitor E-76 and Coagulation Factor Viia
5. 1fak: Human Tissue Factor Complexed with Coagulation Factor Viia Inhibited with a Bpti-mutant
6. 1jbu: Coagulation Factor VII Zymogen (egf2/protease) in Complex with Inhibitory Exosite Peptide A-183
7. 1kli: Cofactor-and Substrate-assisted Activation of Factor Viia
8. 1klj: Crystal Structure of Uninhibited Factor Viia
9. 1o5d: Dissecting and Designing Inhibitor Selectivity Determinants at The S1 Site Using an Artificial Ala190 Protease (ala190 Upa)
10. 1qfk: Structure of Human Factor Viia and Its Implications for The Triggering of Blood Coagulation
11. 3ela: Crystal Structure of Active Site Inhibited Coagulation Factor Viia Mutant in Complex with Soluble Tissue Factor
12. 1w0y: TF7A_3771 Complex
13. 1w2k: TF7A_4380 Complex
14. 1w7x: Factor7- 413 Complex
15. 1w8b: Factor7 - 413 Complex
16. 2zzu: Human Factor Viia-tissue Factor Complexed with Ethylsulfonamide-d-5-(3-carboxybenzyloxy)-trp-gln-p- Aminobenzamidine
17. 2zwl: Human Factor Viia-tissue Factor Complexed with Highly Selective Peptide Inhibitor
18. 1wqv: Human Factor Viia-tissue Factor Complexed with Propylsulfonamide-d-thr-met-p-aminobenzamidine
19. 2zp0: Human Factor Viia-tissue Factor Complexed with Benzylsulfonamide-d-ile-gln-p-aminobenzamidine
20. 1wss: Human Factor Viia-tissue Factor in Complex with Peprid Mimetic Inhibitor That Has Two Charge Groups in P2 and P4
21. 1wtg: Human Factor Viia-tissue Factor Complexed with Ethylsulfonamide-d-biphenylalanine-gln-p-aminobenzamidine
22. 1wun: Human Factor Viia-tissue Factor Complexed with Ethylsulfonamide-d-trp-gln-p-aminobenzamidine
23. 1wv7: Human Factor Viia-tissue Factor Complexed with Ethylsulfonamide-d-5-propoxy-trp-gln-p-aminobenzamidine
24. 1ygc: Short Factor Viia with a Small Molecule Inhibitor
25. 1z6j: Crystal Structure of a Ternary Complex of Factor Viia/tissue Factor/pyrazinone Inhibitor
26. 2a2q: Complex of Active-site Inhibited Human Coagulation Factor Viia with Human Soluble Tissue Factor in The Presence of Ca2+, Mg2+, Na+, and Zn2+
27. 2aei: Crystal Structure of a Ternary Complex of Factor Viia/tissue Factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]- 3,5-difluro-4-[(1-methyl-3-phenylpropyl)amino]-2- Pyridinyl]oxy]-benzoic Acid
28. 2aer: Crystal Structure of Benzamidine-factor Viia/soluble Tissue Factor Complex.
29. 2b7d: Factor Viia Inhibitors: Chemical Optimization, Preclinical Pharmacokinetics, Pharmacodynamics, and Efficacy in a Baboon Thrombosis Model
30. 2b8o: Crystal Structure of Glu-gly-arg-chloromethyl Ketone-factor Viia/soluble Tissue Factor Complex
31. 2bz6: Orally Available FACTOR7A Inhibitor
32. 2c4f: Crystal Structure of Factor Vii.stf Complexed with Pd0297121
33. 2puq: Crystal Structure of Active Site Inhibited Coagulation Factor Viia in Complex with Soluble Tissue Factor
34. 2ec9: Crystal Structure Analysis of Human Factor Viia , Souluble Tissue Factor Complexed with Bcx-3607
35. 2f9b: Discovery of Novel Heterocyclic Factor Viia Inhibitors
36. 2fir: Crystal Structure of Dfpr-viia/stf
37. 2flr: Novel 5-azaindole Factor Viia Inhibitors
38. 6r2w: Crystal Structure of The Super-active Fviia Variant Vyt in Complex with Tissue Factor
39. 3th2: Mg2+ Is Required for Optimal Folding of The Gamma-carboxyglutamic Acid (gla) Domains of Vitamin K-dependent Clotting Factors at Physiological Ca2+
40. 3th3: Mg2+ Is Required for Optimal Folding of The Gamma-carboxyglutamic Acid (gla) Domains of Vitamin K-dependent Clotting Factors at Physiological Ca2+
41. 3th4: Mg2+ Is Required for Optimal Folding of The Gamma-carboxyglutamic Acid (gla) Domains of Vitamin K-dependent Clotting Factors at Physiological Ca2+
42. 4isi: Structure of Factor Viia in Complex with The Inhibitor (6s)-n-(4- Carbamimidoylbenzyl)-1-chloro-3-(cyclobutylamino)-8,8-diethyl-4-oxo- 4,6,7,8-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamide
43. 4ish: Structure of Factor Viia in Complex with The Inhibitor Bms-593214 Also Known as 2'-[(6r,6ar,11br)-2-carbamimidoyl-6,6a,7,11b-tetrahydro-5h- Indeno[2,1-c]quinolin-6-yl]-5'-hydroxy-4'-methoxybiphenyl-4- Carboxylic Acid
44. 4jyu: Structure of Factor Viia in Complex with The Inhibitor (2r)-2-[(1- Aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-n- (phenylsulfonyl)ethanamide
45. 4jyv: Structure of Factor Viia in Complex with The Inhibitor (2r)-2-[3- Ethoxy-4-(propan-2-yloxy)phenyl]-2-(isoquinolin-6-ylamino)-n-[(3- Sulfamoylphenyl)sulfonyl]ethanamide
46. 4ibl: Rubidium Sites in Blood Coagulation Factor Viia
47. 4jzd: Structure of Factor Viia in Complex with The Inhibitor 2-{2-[(4- Carbamimidoylphenyl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2s)-1- Hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic Acid
48. 4jze: Structure of Factor Viia in Complex with The Inhibitor 2-{2-[(1- Aminoisoquinolin-6-yl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2s)-1- Hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic Acid
49. 4jzf: Structure of Factor Viia in Complex with The Inhibitor 2-{2-[(3- Carbamoylphenyl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2s)-1-hydroxy- 3,3-dimethylbutan-2-yl]carbamoyl}benzoic Acid
50. 4na9: Factor Viia in Complex with The Inhibitor 3'-amino-5'-[(2s,4r)-6- Carbamimidoyl-4-phenyl-1,2,3,4-tetrahydroquinolin-2-yl]biphenyl-2- Carboxylic Acid
51. 4ng9: Factor Viia in Complex with The Inhibitor (2r)-2-[(1-aminoisoquinolin- 6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-n-(3- Sulfamoylbenzyl)ethanamide
52. 4nga: Factor Viia in Complex with The Inhibitor (2r)-2-[(1-aminoisoquinolin- 6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-n-[2-(propan-2- Ylsulfonyl)benzyl]ethanamide
53. 5u6j: Factor Viia in Complex with The Inhibitor 3-{[(2r)-17-ethyl-4-methyl- 3,12-dioxo-7-[(propan-2-yl)sulfonyl]-13-oxa-4,11- Diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-2- Yl]amino}benzamide
54. 5tqg: Factor Viia in Complex with The Inhibitor (5r,11r)-11-[(1-amino-4- Fluoroisoquinolin-6-yl)amino]-16-(cyclopropylsulfonyl)-7-(2,2- Difluoroethoxy)-5,13-dimethyl-2,13-diazatricyclo[13.3.1.1~6, 10~]icosa-1(19),6(20),7,9,15,17-hexaene-3,12-dione
55. 5tqf: Factor Viia in Complex with The Inhibitor (11r)-11-[(1- Aminoisoquinolin-6-yl)amino]-16-(cyclopropylsulfonyl)-13-methyl-2,13- Diazatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaene-3, 12-dione
56. 5tqe: Factor Viia in Complex with The Inhibitor (5r)-5-[(1-aminoisoquinolin- 6-yl)amino]-19-(cyclopropylsulfonyl)-3-methyl-13-oxa-3,15- Diazatricyclo[14.3.1.1~6,10~]henicosa-1(20),6(21),7,9,16,18-hexaene- 4,14-dione
57. 5pb6: Crystal Structure of Factor Viia in Complex with N-[[3-[5-hydroxy-4- (1h-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]pentanamide
58. 5pb5: Human Factor Viia in Complex with 1-[[3-[5-hydroxy-4-(7h-pyrrolo[2,3- D]pyrimidin-6-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylurea at 1.84a
59. 5pb4: Human Factor Viia in Complex with 1-[[3-[5-hydroxy-3-methyl-4-(1h- Pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylurea at 2.43a
60. 5pb3: Crystal Structure of Factor Viia in Complex with 1-[[3-[4-(5-amino-1h- Pyrrolo[3,2-b]pyridin-2-yl)-5-hydroxypyrazol-1-yl]phenyl]methyl]-3- Phenylurea
61. 5pb2: Crystal Structure of Factor Viia in Complex with 2-phenyl-4-(1h- Pyrrolo[3,2-c]pyridin-2-yl)pyrazol-3-ol
62. 5pb1: Crystal Structure of Factor Viia in Complex with Benzenecarboximidamide
63. 5pb0: Crystal Structure of Factor Viia in Complex with 2-(4-ethoxy-3- Methoxyphenyl)-2-(isoquinolin-6-ylamino)acetic Acid
64. 5pay: Crystal Structure of Factor Viia in Complex with 1-[[3-[5-hydroxy-4- (1h-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3- Phenylurea
65. 5pax: Crystal Structure of Factor Viia in Complex with 1-(2,6- Difluorophenyl)-3-[[3-[5-hydroxy-4-(1h-pyrrolo[3,2-c]pyridin-2-yl) Pyrazol-1-yl]phenyl]methyl]urea
66. 5paw: Crystal Structure of Factor Viia in Complex with Isoquinoline-1,6- Diamine
67. 5pav: Crystal Structure of Factor Viia in Complex with N-(6-aminopyridin-3- Yl)-5-hydroxy-1-phenylpyrazole-4-carboxamide
68. 5pau: Crystal Structure of Factor Viia in Complex with N-(2-amino-1h- Benzimidazol-5-yl)-2-[3-[(2-amino-2-oxoethyl)- Methylsulfonylamino]phenyl]acetamide;2,2,2-trifluoroacetic Acid
69. 5pat: Crystal Structure of Factor Viia in Complex with N-(2-amino-1h- Benzimidazol-5-yl)-2-(3-chlorophenyl)acetamide
70. 5pas: Crystal Structure of Factor Viia in Complex with (2s)-2-hydroxy-n-[[3- [5-hydroxy-4-(1h-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1- Yl]phenyl]methyl]-3-phenylpropanamide
71. 5par: Crystal Structure of Factor Viia in Complex with 1h-benzimidazol-2- Amine
72. 5paq: Crystal Structure of Factor Viia in Complex with 2-[(1- Aminoisoquinolin-6-yl)amino]-2-(3-ethoxy-4-propan-2-yloxyphenyl)-1- (2-phenylpyrrolidin-1-yl)ethanone
73. 5pao: Crystal Structure of Factor Viia in Complex with (2s)-2,3-dihydroxy-n- [[3-[5-hydroxy-4-(1h-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1- Yl]phenyl]methyl]propanamide;hydrobromide
74. 5pan: Crystal Structure of Factor Viia in Complex with 5-hydroxy-n-(3-oxo-1, 2-dihydroisoindol-5-yl)-1-[3-[(phenylcarbamoylamino) Methyl]phenyl]pyrazole-4-carboxamide
75. 5pam: Crystal Structure of Factor Viia in Complex with 2-[(1- Aminoisoquinolin-6-yl)amino]-2-(5-ethoxy-2-fluorophenyl)-1-(2- Phenylpyrrolidin-1-yl)ethanone
76. 5pak: Crystal Structure of Factor Viia in Complex with N-[[4-(aminomethyl)- 2-(2-amino-2-oxoethoxy)phenyl]methyl]-2-(4-hydroxyphenyl)-2- Methoxyacetamide;hydrochloride
77. 5paj: Crystal Structure of Factor Viia in Complex with 1-(1- Aminoisoquinolin-6-yl)-3-benzylurea
78. 5pai: Human Factor Viia in Complex with N-(2-amino-1h-benzimidazol-5-yl)-1- [3-[[(3,5-dimethyl-1,2-oxazol-4-yl)carbamoylamino]methyl]phenyl]-5- Hydroxypyrazole-4-carboxamide at 1.73a
79. 5pag: Crystal Structure of Factor Viia in Complex with (2r)-2-hydroxy-n-[[3- [5-hydroxy-4-(1h-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1- Yl]phenyl]methyl]-3-methylbutanamide;hydrobromide
80. 5paf: Crystal Structure of Factor Viia in Complex with N-(2-amino-1h- Benzimidazol-5-yl)-2-[3-[(2-amino-2-oxoethyl)-methylsulfonylamino]-5- Chlorophenyl]acetamide;2,2,2-trifluoroacetic Acid
81. 5pae: Crystal Structure of Factor Viia in Complex with (2s)-2-hydroxy-n-[[3- [5-hydroxy-4-(1h-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1- Yl]phenyl]methyl]propanamide
82. 5pac: Human Factor Viia in Complex with 5-hydroxy-n-(4-oxo-3h-quinazolin-6- Yl)-1-[3-[(phenylcarbamoylamino)methyl]phenyl]pyrazole-4-carboxamide at 1.50a
83. 5pab: Crystal Structure of Factor Viia in Complex with 1-[[3-[2-hydroxy-3- (1h-pyrrolo[3,2-c]pyridin-2-yl)phenyl]phenyl]methyl]-3-phenylurea
84. 5paa: Crystal Structure of Factor Viia in Complex with Cyclohexylmethanamine
85. 5pa9: Crystal Structure of Factor Viia in Complex with Phenylmethanamine;hydrochloride
86. 5pa8: Crystal Structure of Factor Viia in Complex with Cyclohexanamine
87. 5l30: Factor Viia in Complex with The Inhibitor (2r,15r)-2-[(1- Aminoisoquinolin-6-yl)amino]-4,15,17-trimethyl-7-[1-(1h-tetrazol-5- Yl)cyclopropyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa- 1(18),6(21),7,9,16,19-hexaene-3,12-dione
88. 5l2z: Factor Viia in Complex with The Inhibitor 1-[(2r,15r)-2-[(1-amino-4- Fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4, 11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19- Hexaen-7-yl]cyclohexane-1-carboxylic Acid
89. 5l2y: Factor Viia in Complex with The Inhibitor 1-[(2r,15r)-2-[(1-amino-4- Fluoroisoquinolin-6-yl)amino]-4,15,20-trimethyl-3,12-dioxo-13-oxa-4, 11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6,8,10(21),16,19- Hexaen-7-yl] Cyclobutane-1-carboxylic Acid
90. 5l0s: Human Poglut1 in Complex with Factor VII Egf1 and Udp
91. 5ky3: Mouse Pofut1 in Complex with Mouse Factor VII Egf1 Mutant (T101A) and Gdp-fucose
92. 5ky2: Mouse Pofut1 in Complex with O-glucosylated Mouse Factor VII Egf1 and Gdp
93. 5kxh: Mouse Pofut1 in Complex with Mouse Factor VII Egf1 and Gdp
94. 5i46: Factor Viia in Complex with The Inhibitor (2r,15r)-2-[(1- Aminoisoquinolin-6-yl)amino]-8-fluoro-7-hydroxy-4,15,17-trimethyl-13- Oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19- Hexaene-3,12-dione
95. 4zxy: Factor Viia in Complex with The Inhibitor (2r)-2-[(1-aminoisoquinolin- 6-yl)amino]-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7, 9,16,19-hexaene-3,12-dione
96. 4zxx: Factor Viia in Complex with The Inhibitor N-{3-[(2r)-1-{(2r)-2-[(1- Aminoisoquinolin-6-yl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-4- (propan-2-ylsulfonyl)phenyl}acetamide
97. 4zma: Crystal Structure of a Fviia-trypsin Chimera (st) in Complex with Soluble Tissue Factor
98. 4z6a: Crystal Structure of a Fviia-trypsin Chimera (yt) in Complex with Soluble Tissue Factor
99. 4x8s: Factor Viia in Complex with The Inhibitor 4-bromo-2-methoxyphenol
100. 4x8t: Factor Viia in Complex with The Inhibitor 7-chloro-3,4- Dihydroisoquinolin-1(2h)-one
101. 4x8u: Factor Viia in Complex with The Inhibitor 5-chloro-1h-indole-2- Carboxylic Acid
102. 4x8v: Factor Viia in Complex with The Inhibitor (methyl {3-[(2r)-1-{(2r)-2- (3,4-dimethoxyphenyl)-2-[(1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl) Amino]acetyl}pyrrolidin-2-yl]-4-(propan-2-ylsulfonyl) Phenyl}carbamate)
103. 4ylq: Crystal Structure of a Fviia-trypsin Chimera (ft) in Complex with Soluble Tissue Factor
104. 4yt6: Factor Viia in Complex with The Inhibitor 4-{[(r)-[5-ethoxy-2-fluoro- 3-(propan-2-yloxy)phenyl](4-phenyl-1h-imidazol-2-yl) Methyl]amino}benzenecarboximidamide
105. 4yt7: Factor Viia in Complex with The Inhibitor 2-(2-{(r)-[(4- Carbamimidoylphenyl)amino][5-ethoxy-2-fluoro-3-(propan-2-yloxy) Phenyl]methyl}-1h-imidazol-4-yl)benzamide