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enzyme (lysozyme)

 
Enzymes
  Enzyme classes:
  EC 1: Oxidoreductases
  EC 2: Transferases
  EC 3: Hydrolases
    EC 3.1
    EC 3.2
    EC 3.3
    EC 3.4
      EC 3.4.1
      EC 3.4.2
      EC 3.4.3
      EC 3.4.4
      EC 3.4.11
      EC 3.4.12
      EC 3.4.13
      EC 3.4.14
      EC 3.4.15
      EC 3.4.16
      EC 3.4.17
      EC 3.4.18
      EC 3.4.19
      EC 3.4.21
        EC 3.4.21.1
        EC 3.4.21.2
        EC 3.4.21.3
        EC 3.4.21.4
        EC 3.4.21.5
        EC 3.4.21.6
        EC 3.4.21.7
        EC 3.4.21.8
        EC 3.4.21.9
        EC 3.4.21.10
        EC 3.4.21.11
        EC 3.4.21.12
        EC 3.4.21.13
        EC 3.4.21.14
        EC 3.4.21.15
        EC 3.4.21.16
        EC 3.4.21.17
        EC 3.4.21.18
        EC 3.4.21.19
        EC 3.4.21.20
        EC 3.4.21.21
        EC 3.4.21.22
        EC 3.4.21.23
        EC 3.4.21.24
        EC 3.4.21.25
        EC 3.4.21.26
        EC 3.4.21.27
        EC 3.4.21.28
        EC 3.4.21.29
        EC 3.4.21.30
        EC 3.4.21.31
        EC 3.4.21.32
        EC 3.4.21.33
        EC 3.4.21.34
        EC 3.4.21.35
        EC 3.4.21.36
        EC 3.4.21.37
        EC 3.4.21.38
        EC 3.4.21.39
        EC 3.4.21.40
        EC 3.4.21.41
        EC 3.4.21.42
        EC 3.4.21.43
        EC 3.4.21.44
        EC 3.4.21.45
        EC 3.4.21.46
        EC 3.4.21.47
        EC 3.4.21.48
        EC 3.4.21.49
        EC 3.4.21.50
        EC 3.4.21.51
        EC 3.4.21.52
        EC 3.4.21.53
        EC 3.4.21.54
        EC 3.4.21.55
        EC 3.4.21.56
        EC 3.4.21.57
        EC 3.4.21.58
        EC 3.4.21.59
        EC 3.4.21.60
        EC 3.4.21.61
        EC 3.4.21.62
        EC 3.4.21.63
        EC 3.4.21.64
        EC 3.4.21.65
        EC 3.4.21.66
        EC 3.4.21.67
        EC 3.4.21.68
        EC 3.4.21.69
        EC 3.4.21.70
        EC 3.4.21.71
        EC 3.4.21.72
        EC 3.4.21.73
        EC 3.4.21.74
        EC 3.4.21.75
        EC 3.4.21.76
        EC 3.4.21.77
        EC 3.4.21.78
        EC 3.4.21.79
        EC 3.4.21.80
        EC 3.4.21.81
        EC 3.4.21.82
        EC 3.4.21.83
        EC 3.4.21.84
        EC 3.4.21.85
        EC 3.4.21.86
        EC 3.4.21.87
        EC 3.4.21.88
        EC 3.4.21.89
        EC 3.4.21.90
        EC 3.4.21.91
        EC 3.4.21.92
        EC 3.4.21.93
        EC 3.4.21.94
        EC 3.4.21.95
        EC 3.4.21.96
        EC 3.4.21.97
        EC 3.4.21.98
        EC 3.4.21.99
        EC 3.4.21.100
        EC 3.4.21.101
        EC 3.4.21.102
        EC 3.4.21.103
        EC 3.4.21.104
        EC 3.4.21.105
        EC 3.4.21.106
        EC 3.4.21.107
        EC 3.4.21.108
        EC 3.4.21.109
        EC 3.4.21.110
        EC 3.4.21.111
        EC 3.4.21.112
        EC 3.4.21.113
        EC 3.4.21.114
        EC 3.4.21.115
        EC 3.4.21.116
        EC 3.4.21.117
        EC 3.4.21.118
        EC 3.4.21.119
        EC 3.4.21.120
      EC 3.4.22
      EC 3.4.23
      EC 3.4.24
      EC 3.4.25
      EC 3.4.99
    EC 3.5
    EC 3.6
    EC 3.7
    EC 3.8
    EC 3.9
    EC 3.10
    EC 3.11
    EC 3.12
    EC 3.13
  EC 4: Lyases
  EC 5: Isomerases
  EC 6: Ligases
  General information:
  Catalytic mechanism
  Enzyme kinetics
  Inhibitors
  Enzymes in industry

EC 3.4.21.5 - thrombin



3D structures of EC 3.4.21.5 - thrombin in Protein Data Bank

updated: 22 January 2021, 10:46

In total: 455 PDB structures of EC 3.4.21.5 - thrombin:
  1. 1a0h: The X-ray Crystal Structure of Ppack-meizothrombin Desf1: Kringle/thrombin and Carbohydrate/kringle/thrombin Interactions and Location of The Linker Chain
  2. 1a2c: Structure of Thrombin Inhibited by Aeruginosin298-a from a Blue-green Alga
  3. 1a3b: Complex of Human Alpha-thrombin with The Bifunctional Boronate Inhibitor Borolog1
  4. 1a3e: Complex of Human Alpha-thrombin with The Bifunctional Boronate Inhibitor Borolog2
  5. 1a46: Thrombin Complexed with Hirugen and a Beta-strand Mimetic Inhibitor
  6. 1a4w: Crystal Structures of Thrombin with Thiazole-containing Inhibitors: Probes of The S1' Binding Site
  7. 1a5g: Human Thrombin Complexed with Novel Synthetic Peptide Mimetic Inhibitor and Hirugen
  8. 1a61: Thrombin Complexed with a Beta-mimetic Thiazole-containing Inhibitor
  9. 1abi: Structure of The Hirulog 3-thrombin Complex and Nature of The S' Subsites of Substrates and Inhibitors
  10. 1abj: Structure of The Hirulog 3-thrombin Complex and Nature of The S' Subsites of Substrates and Inhibitors
  11. 1ad8: Complex of Thrombin with and Inhibitor Containing a Novel P1 Moiety
  12. 1ae8: Human Alpha-thrombin Inhibition by Eoc-d-phe-pro-azalys-onp
  13. 1afe: Human Alpha-thrombin Inhibition by Cbz-pro-azalys-onp
  14. 1aht: Crystal Structure of Human Alpha-thrombin Complexed with Hirugen and P-amidinophenylpyruvate) at 1.6 Angstroms Resolution
  15. 1ai8: Human Alpha-thrombin Ternary Complex with The Exosite Inhibitor Hirugen and Active Site Inhibitor PHCH2OCO-D-DPA- Pro-borompg
  16. 1aix: Human Alpha-thrombin Ternary Complex with Exosite Inhibitor Hirugen and Active Site Inhibitor PHCH2OCO-D-DPA-PRO- Boroval
  17. 1avg: Thrombin Inhibitor from Triatoma Pallidipennis
  18. 1awf: Novel Covalent Thrombin Inhibitor from Plant Extract
  19. 1awh: Novel Covalent Thrombin Inhibitor from Plant Extract
  20. 1ay6: Thrombin Inhibitor from Theonalla, Cyclotheanamide-based Macrocyclic Tripeptide Motif
  21. 1b5g: Human Thrombin Complexed with Novel Synthetic Peptide Mimetic Inhibitor and Hirugen
  22. 1b7x: Structure of Human Alpha-thrombin Y225I Mutant Bound to D- Phe-pro-arg-chloromethylketone
  23. 1ba8: Thrombin Inhibitor with a Rigid Tripeptidyl Aldehydes
  24. 1bb0: Thrombin Inhibitors with Rigid Tripeptidyl Aldehydes
  25. 1bbr: The Structure of Residues 7-16 of The a Alpha Chain of Human Fibrinogen Bound to Bovine Thrombin at 2.3 Angstroms Resolution
  26. 1bcu: Alpha-thrombin Complexed with Hirugen and Proflavin
  27. 1bhx: X-ray Structure of The Complex of Human Alpha Thrombin with The Inhibitor Sdz 229-357
  28. 1bmm: Human Alpha-thrombin Complexed with [s-(r*,r*)]-4- [(aminoiminomethyl)amino]-n-[[1-[3-hydroxy-2-[(2- Naphthalenylsulfonyl)amino]-1-oxopropyl]-2-pyrrolidinyl] Methyl]butanamide (bms-186282)
  29. 1bmn: Human Alpha-thrombin Complexed with [s-(r*,r*)]-1- (aminoiminomethyl)-n-[[1-[n-[(2-naphthalenylsulfonyl)-l- Seryl]-pyrrolidinyl]methyl]-3-piperidenecarboxamide (bms- 189090)
  30. 1bth: Structure of Thrombin Complexed with Bovine Pancreatic Trypsin Inhibitor
  31. 1c1u: Recruiting Zinc to Mediate Potent, Specific Inhibition of Serine Proteases
  32. 1c1v: Recruiting Zinc to Mediate Potent, Specific Inhibition of Serine Proteases
  33. 1c1w: Recruiting Zinc to Mediate Potent, Specific Inhibition of Serine Proteases
  34. 1c4u: Selective Non Electrophilic Thrombin Inhibitors with Cyclohexyl Moieties.
  35. 1c4v: Selective Non Electrophilic Thrombin Inhibitors with Cyclohexyl Moieties.
  36. 1c4y: Selective Non-electrophilic Thrombin Inhibitors
  37. 1c5l: Structural Basis for Selectivity of a Small Molecule, S1- Binding, Sub-micromolar Inhibitor of Urokinase Type Plasminogen Activator
  38. 1c5n: Structural Basis for Selectivity of a Small Molecule, S1- Binding, Sub-micromolar Inhibitor of Urokinase Type Plasminogen Activator
  39. 1c5o: Structural Basis for Selectivity of a Small Molecule, S1- Binding, Sub-micromolar Inhibitor of Urokinase Type Plasminogen Activator
  40. 1ca8: Thrombin Inhibitors with Rigid Tripeptidyl Aldehydes
  41. 1d3d: Crystal Structure of Human Alpha Thrombin in Complex with Benzothiophene Inhibitor 4
  42. 1d3p: Crystal Structure of Human Aplha-thrombin in Complex with Benzo[b]thiophene Inhibitor 3
  43. 1d3q: Crystal Structure of Human Alpha Thrombin in Complex with Benzo[b]thiophene Inhibitor 2
  44. 1d3t: Crystal Structure of Human Alpha Thrombin in Complex with Benzo[b]thiophene Inhibitor 1
  45. 1d4p: Crystal Structure of Human Alpha Thrombin in Complex with 5- Amidinoindole-4-benzylpiperidine Inhibitor
  46. 1d6w: Structure of Thrombin Complexed with Selective Non- Electrophilic Inhibitors Having Cyclohexyl Moieties at P1
  47. 1d9i: Structure of Thrombin Complexed with Selective Non- Electophilic Inhibitors Having Cyclohexyl Moieties at P1
  48. 1de7: Interaction of Factor XIII Activation Peptide with Alpha- Thrombin: Crystal Structure of The Enzyme-substrate Complex
  49. 1dit: Complex of a Divalent Inhibitor with Thrombin
  50. 1doj: Crystal Structure of Human Alpha-thrombin*rwj-51438 Complex at 1.7 a
  51. 1dwb: Crystallographic Analysis at 3.0-angstroms Resolution of The Binding to Human Thrombin of Four Active Site-directed Inhibitors
  52. 1dwc: Crystallographic Analysis at 3.0-angstroms Resolution of The Binding to Human Thrombin of Four Active Site-directed Inhibitors
  53. 1dwd: Crystallographic Analysis at 3.0-angstroms Resolution of The Binding to Human Thrombin of Four Active Site-directed Inhibitors
  54. 1dwe: Crystallographic Analysis at 3.0-angstroms Resolution of The Binding to Human Thrombin of Four Active Site-directed Inhibitors
  55. 1dx5: Crystal Structure of The Thrombin-thrombomodulin Complex
  56. 1e0f: Crystal Structure of The Human Alpha-thrombin-haemadin Complex: an Exosite Ii-binding Inhibitor
  57. 1eb1: Complex Structure of Human Thrombin with N-methyl-arginine Inhibitor
  58. 1eoj: Design of P1' and P3' Residues of Trivalent Thrombin Inhibitors and Their Crystal Structures
  59. 1eol: Design of P1' and P3' Residues of Trivalent Thrombin Inhibitors and Their Crystal Structures
  60. 1etr: Refined 2.3 Angstroms X-ray Crystal Structure of Bovine Thrombin Complexes Formed with The Benzamidine and Arginine-based Thrombin Inhibitors Napap, 4-tapap and Mqpa: a Starting Point for Improving Antithrombotics
  61. 1ets: Refined 2.3 Angstroms X-ray Crystal Structure of Bovine Thrombin Complexes Formed with The Benzamidine and Arginine-based Thrombin Inhibitors Napap, 4-tapap and Mqpa: a Starting Point for Improving Antithrombotics
  62. 1ett: Refined 2.3 Angstroms X-ray Crystal Structure of Bovine Thrombin Complexes Formed with The Benzamidine and Arginine-based Thrombin Inhibitors Napap, 4-tapap and Mqpa: a Starting Point for Improving Antithrombotics
  63. 1fpc: Active Site Mimetic Inhibition of Thrombin
  64. 1fph: The Interaction of Thrombin with Fibrinogen: a Structural Basis for Its Specificity
  65. 1g30: Thrombin Inhibitor Complex
  66. 1g32: Thrombin Inhibitor Complex
  67. 1g37: Crystal Structure of Human Alpha-thrombin Complexed with Bch-10556 and Exosite-directed Peptide
  68. 1ghv: A Novel Serine Protease Inhibition Motif Involving a Multi- Centered Short Hydrogen Bonding Network at The Active Site
  69. 1ghw: A Novel Serine Protease Inhibition Motif Involving a Multi- Centered Short Hydrogen Bonding Network at The Active Site
  70. 1ghx: A Novel Serine Protease Inhibition Motif Involving a Multi- Centered Short Hydrogen Bonding Network at The Active Site
  71. 1ghy: A Novel Serine Protease Inhibition Motif Involving a Multi- Centered Short Hydrogen Bonding Network at The Active Site
  72. 1gj4: Selectivity at S1, H2O Displacement, Upa, Tpa, Ser190/ala190 Protease, Structure-based Drug Design
  73. 1gj5: Selectivity at S1, H2O Displacement, Upa, Tpa, Ser190/ala190 Protease, Structure-based Drug Design
  74. 1h8d: X-ray Structure of The Human Alpha-thrombin Complex with a Tripeptide Phosphonate Inhibitor.
  75. 1h8i: X-ray Crystal Structure of Human Alpha-thrombin with a Tripeptide Phosphonate Inhibitor.
  76. 1hag: The Isomorphous Structures of Prethrombin2, Hirugen-and Ppack-thrombin: Changes Accompanying Activation and Exosite Binding to Thrombin
  77. 1hah: The Isomorphous Structures of Prethrombin2, Hirugen-and Ppack-thrombin: Changes Accompanying Activation and Exosite Binding to Thrombin
  78. 1hai: The Isomorphous Structures of Prethrombin2, Hirugen-and Ppack-thrombin: Changes Accompanying Activation and Exosite Binding to Thrombin
  79. 1hao: Complex of Human Alpha-thrombin with a 15mer Oligonucleotide Ggttggtgtggttgg (based on Nmr Model of Dna
  80. 1hap: Complex of Human Alpha-thrombin with a 15mer Oligonucleotide Ggttggtgtggttgg (based on X-ray Model of Dna)
  81. 1hbt: Human Alpha-thrombin Complexed with a Peptidyl Pyridinium Methyl Ketone Containing Bivalent Inhibitor
  82. 1hdt: Structure of a Retro-binding Peptide Inhibitor Complexed with Human Alpha-thrombin
  83. 1hgt: Structure of The Hirugen and Hirulog 1 Complexes of Alpha- Thrombin
  84. 1hrt: The Structure of a Complex of Bovine Alpha-thrombin and Recombinant Hirudin at 2.8 Angstroms Resolution
  85. 1hut: The Structure of Alpha-thrombin Inhibited by a 15-mer Single-stranded Dna Aptamer
  86. 1hxe: Serine Protease
  87. 1hxf: Human Thrombin Complex with Hirudin Variant
  88. 1id5: Crystal Structure of Bovine Thrombin Complex with Protease Inhibitor Ecotin
  89. 1ihs: Crystal Structure of The Complex of Human Alpha-thrombin and Non-hydrolyzable Bifunctional Inhibitors, Hirutonin-2 and Hirutonin-6
  90. 1iht: Crystal Structure of The Complex of Human Alpha-thrombin and Non-hydrolyzable Bifunctional Inhibitors, Hirutonin-2 and Hirutonin-6
  91. 1jmo: Crystal Structure of The Heparin Cofactor II-S195A Thrombin Complex
  92. 1jwt: Crystal Structure of Thrombin in Complex with a Novel Bicyclic Lactam Inhibitor
  93. 1k21: Human Thrombin-inhibitor Complex
  94. 1k22: Human Thrombin-inhibitor Complex
  95. 8kme: Crystal Structure of Human Alpha-thrombin Inhibited with Sel2770.
  96. 7kme: Crystal Structure of Human Alpha-thrombin Inhibited with Sel2711.
  97. 5gds: Hirunorms Are True Hirudin Mimetics. The Crystal Structure of Human Alpha-thrombin:hirunorm V Complex
  98. 4thn: The Crystal Structure of Alpha-thrombin-hirunorm IV Complex Reveals a Novel Specificity Site Recognition Mode.
  99. 4htc: The Refined Structure of The Hirudin-thrombin Complex
  100. 1kts: Thrombin Inhibitor Complex
  101. 1ktt: Thrombin Inhibitor Complex
  102. 1lhc: Human Alpha-thrombin Complexed with Ac-(d)phe-pro-boroarg-oh
  103. 1lhd: Human Alpha-thrombin Complexed with Ac-(d)phe-pro-borolys-oh
  104. 1lhe: Human Alpha-thrombin Complexed with Ac-(d)phe-pro-boro-n- Butyl-amidino-glycine-oh
  105. 1lhf: Human Alpha-thrombin Complexed with Ac-(d)phe-pro-boro- Homolys-oh
  106. 1lhg: Human Alpha-thrombin Complexed with Ac-(d)phe-pro- Boroornithine-oh
  107. 3nxp: Crystal Structure of Human Prethrombin-1
  108. 1mh0: Crystal Structure of The Anticoagulant Slow Form of Thrombin
  109. 1mkw: The Co-crystal Structure of Unliganded Bovine Alpha- Thrombin and Prethrombin-2: Movement of The Yppw Segment and Active Site Residues upon Ligand Binding
  110. 1mkx: The Co-crystal Structure of Unliganded Bovine Alpha- Thrombin and Prethrombin-2: Movement of The Yppw Segment and Active Site Residues upon Ligand Binding
  111. 1mu6: Crystal Structure of Thrombin in Complex with L-378,622
  112. 1mu8: Thrombin-hirugen_l-378,650
  113. 1mue: Thrombin-hirugen-l405,426
  114. 3lu9: Crystal Structure of Human Thrombin Mutant S195A in Complex with The Extracellular Fragment of Human Par1
  115. 1nl1: Bovine Prothrombin Fragment 1 in Complex with Calcium Ion
  116. 1nl2: Bovine Prothrombin Fragment 1 in Complex with Calcium and Lysophosphotidylserine
  117. 1nm6: Thrombin in Complex with Selective Macrocyclic Inhibitor at 1.8a
  118. 1no9: Design of Weakly Basic Thrombin Inhibitors Incorporating Novel P1 Binding Functions: Molecular and X-ray Crystallographic Studies.
  119. 1nrn: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
  120. 1nro: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
  121. 1nrp: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
  122. 1nrq: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
  123. 1nrr: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
  124. 1nrs: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
  125. 1nt1: Thrombin in Complex with Selective Macrocyclic Inhibitor
  126. 1nu7: Staphylocoagulase-thrombin Complex
  127. 1nu9: Staphylocoagulase-prethrombin-2 Complex
  128. 1ny2: Human Alpha Thrombin Inhibited by Rppgf and Hirugen
  129. 1nzq: D-phe-pro-arg-type Thrombin Inhibitor
  130. 1o0d: Human Thrombin Complexed with a D-phe-pro-arg-type Inhibitor and a C-terminal Hirudin Derived Exo-site Inhibitor
  131. 1o2g: Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors
  132. 1o5g: Dissecting and Designing Inhibitor Selectivity Determinants at The S1 Site Using an Artificial Ala190 Protease (ala190 Upa)
  133. 1ook: Crystal Structure of The Complex of Platelet Receptor Gpib- Alpha and Human Alpha-thrombin
  134. 3k65: Crystal Structure of Prethombin-2/fragment-2 Complex
  135. 3jz2: Crystal Structure of Human Thrombin Mutant N143P in E* Form
  136. 3jz1: Crystal Structure of Human Thrombin Mutant N143P in E:na+ Form
  137. 1oyt: Complex of Recombinant Human Thrombin with a Designed Fluorinated Inhibitor
  138. 1p8v: Crystal Structure of The Complex of Platelet Receptor Gpib- Alpha and Alpha-thrombin at 2.6a
  139. 1ppb: The Refined 1.9 Angstroms Crystal Structure of Human Alpha- Thrombin: Interaction with D-phe-pro-arg Chloromethylketone and Significance of The Tyr-pro-pro-trp Insertion Segment
  140. 1qbv: Crystal Structure of Thrombin Complexed with an Guanidine- Mimetic Inhibitor
  141. 3htc: The Structure of a Complex of Recombinant Hirudin and Human Alpha-thrombin
  142. 1qhr: Novel Covalent Active Site Thrombin Inhibitors
  143. 1qj1: Novel Covalent Active Site Thrombin Inhibitors
  144. 1qj6: Novel Covalent Active Site Thrombin Inhibitors
  145. 1qj7: Novel Covalent Active Site Thrombin Inhibitors
  146. 3hkj: Crystal Structure of Human Thrombin Mutant W215A/E217A in Complex with The Extracellular Fragment of Human Par1
  147. 3hki: Crystal Structure of Murine Thrombin Mutant W215A/E217A in Complex with The Extracellular Fragment of Human Par1
  148. 3hk6: Crystal Structure of Murine Thrombin Mutant W215A/E217A (two Molecules in The Asymmetric Unit)
  149. 3hk3: Crystal Structure of Murine Thrombin Mutant W215A/E217A (one Molecule in The Asymmetric Unit)
  150. 3hat: Active Site Mimetic Inhibition of Thrombin
  151. 1rd3: 2.5a Structure of Anticoagulant Thrombin Variant E217K
  152. 1riw: Thrombin in Complex with Natural Product Inhibitor Oscillarin
  153. 3gis: Crystal Structure of Na-free Thrombin in Complex with Thrombomodulin
  154. 3gic: Structure of Thrombin Mutant Delta(146-149e) in The Free Form
  155. 1sb1: Novel Non-covalent Thrombin Inhibitors Incorporating P1 4,5, 6,7-tetrahydrobenzothiazole Arginine Side Chain Mimetics
  156. 1sfq: Fast Form of Thrombin Mutant R(77a)a Bound to Ppack
  157. 1sg8: Crystal Structure of The Procoagulant Fast Form of Thrombin
  158. 1sgi: Crystal Structure of The Anticoagulant Slow Form of Thrombin
  159. 1shh: Slow Form of Thrombin Bound with Ppack
  160. 1sl3: Crystal Structue of Thrombin in Complex with a Potent P1 Heterocycle-aryl Based Inhibitor
  161. 1sr5: Antithrombin-anhydrothrombin-heparin Ternary Complex Structure
  162. 3f68: Thrombin Inhibition
  163. 1t4u: Crystal Structure Analysis of a Novel Oxyguanidine Bound to Thrombin
  164. 1t4v: Crystal Structure Analysis of a Novel Oxyguanidine Bound to Thrombin
  165. 3eq0: Thrombin Inhibitor
  166. 1ta2: Crystal Structure of Thrombin in Complex with Compound 1
  167. 1ta6: Crystal Structure of Thrombin in Complex with Compound 14b
  168. 1tb6: 2.5a Crystal Structure of The Antithrombin-thrombin-heparin Ternary Complex
  169. 1tbq: Crystal Structure of Insect Derived Double Domain Kazal Inhibitor Rhodniin in Complex with Thrombin
  170. 1tbr: Crystal Structure of Insect Derived Double Domain Kazal Inhibitor Rhodniin in Complex with Thrombin
  171. 1tbz: Human Thrombin with Active Site N-methyl-d Phenylalanyl-n- [5-(aminoiminomethyl)amino]-1-{{benzothiazolyl)carbonyl] Butyl]-l-prolinamide Trifluroacetate and Exosite-hirugen
  172. 1thp: Structure of Human Alpha-thrombin Y225P Mutant Bound to D- Phe-pro-arg-chloromethylketone
  173. 1thr: Structures of Thrombin Complexes with a Designed and a Natural Exosite Inhibitor
  174. 1ths: Structures of Thrombin Complexes with a Designed and a Natural Exosite Inhibitor
  175. 3egk: Knoble Inhibitor
  176. 3ee0: Crystal Structure of The W215A/E217A Mutant of Human Thrombin (space Group P2(1)2(1)2(1))
  177. 3edx: Crystal Structure of The W215A/E217A Mutant of Murine Thrombin
  178. 1tmb: Molecular Basis for The Inhibition of Human Alpha-thrombin by The Macrocyclic Peptide Cyclotheonamide a
  179. 1tmt: Changes in Interactions in Complexes of Hirudin Derivatives and Human Alpha-thrombin due to Different Crystal Forms
  180. 1tmu: Changes in Interactions in Complexes of Hirudin Derivatives and Human Alpha-thrombin due to Different Crystal Forms
  181. 1toc: Structure of Serine Proteinase
  182. 3e6p: Crystal Structure of Human Meizothrombin Desf1
  183. 1tom: Alpha-thrombin Complexed with Hirugen
  184. 1tq0: Crystal Structure of The Potent Anticoagulant Thrombin Mutant W215A/E217A in Free Form
  185. 1tq7: Crystal Structure of The Anticoagulant Thrombin Mutant W215A/E217A Bound to Ppack
  186. 1twx: Crystal Structure of The Thrombin Mutant D221A/D222K
  187. 3dux: Understanding Thrombin Inhibition
  188. 3dt0: Understanding Thrombin Inhibition
  189. 3dhk: Bisphenylic Thrombin Inhibitors
  190. 1ucy: Thrombin Complexed with Fibrinopeptide a Alpha (residues 7- 19). Three Complexes, One with Epsilon-thrombin and Two with Alpha-thrombin
  191. 3dd2: Crystal Structure of an Rna Aptamer Bound to Human Thrombin
  192. 3da9: Crystal Structure of Thrombin in Complex with Inhibitor
  193. 3d49: Thrombin Inhibition
  194. 1uma: Alpha-thrombin (hirugen) Complexed with Na-(n,n- Dimethylcarbamoyl)-alpha-azalysine
  195. 1uvs: Bovine Thrombin--bm51.1011 Complex
  196. 1uvt: Bovine Thrombin--bm14.1248 Complex
  197. 1uvu: Bovine Thrombin--bm12.1700 Complex
  198. 1vit: Thrombin:hirudin 51-65 Complex
  199. 3c27: Cyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors
  200. 3c1k: Crystal Structure of Thrombin in Complex with Inhibitor 15
  201. 3bv9: Structure of Thrombin Bound to The Inhibitor Fm19
  202. 1vr1: Specifity for Plasminogen Activator Inhibitor-1
  203. 1vzq: Complex of Thrombin with Designed Inhibitor 7165
  204. 3biv: Human Thrombin-in Complex with Ub-thr11
  205. 3biu: Human Thrombin-in Complex with Ub-thr10
  206. 3bf6: Thrombin:suramin Complex
  207. 3bei: Crystal Structure of The Slow Form of Thrombin in a Self_inhibited Conformation
  208. 3bef: Crystal Structure of Thrombin Bound to The Extracellular Fragment of Par1
  209. 1w7g: Alpha-thrombin Complex with Sulfated Hirudin (residues 54- 65) and L-arginine Template Inhibitor Cs107
  210. 3b9f: 1.6 a Structure of The Pci-thrombin-heparin Complex
  211. 1way: Active Site Thrombin Inhibitors
  212. 1wbg: Active Site Thrombin Inhibitors
  213. 2zo3: Bisphenylic Thrombin Inhibitors
  214. 2znk: Thrombin Inhibition
  215. 2ziq: Thrombin Inhibition
  216. 2zi2: Thrombin Inhibition
  217. 2zhw: Exploring Thrombin S3 Pocket
  218. 2zhq: Thrombin Inhibition
  219. 2zhf: Exploring Thrombin S3 Pocket
  220. 2zhe: Exploring Thrombin S3 Pocket
  221. 2zgx: Thrombin Inhibition
  222. 2zgb: Thrombin Inhibition
  223. 2zg0: Exploring Thrombin S3 Pocket
  224. 2zfr: Exploring Thrombin S3 Pocket
  225. 2zfq: Exploring Thrombin S3 Pocket
  226. 2zfp: Thrombin Inibition
  227. 2zff: Exploring Thrombin S1-pocket
  228. 2zf0: Exploring Thrombin S1 Pocket
  229. 2zdv: Exploring Thrombin S1 Pocket
  230. 2zda: Exploring Thrombin S1 Pocket
  231. 2zc9: Thrombin in Complex with Inhibitor
  232. 1xm1: Nonbasic Thrombin Inhibitor Complex
  233. 1xmn: Crystal Structure of Thrombin Bound to Heparin
  234. 1ycp: The Crystal Structure of Fibrinogen-aa Peptide 1-23 (F8Y) Bound to Bovine Thrombin Explains Why The Mutation of Phe- 8 to Tyrosine Strongly Inhibits Normal Cleavage at Arginine-16
  235. 1ype: Thrombin Inhibitor Complex
  236. 1ypg: Thrombin Inhibitor Complex
  237. 1ypj: Thrombin Inhibitor Complex
  238. 1ypk: Thrombin Inhibitor Complex
  239. 1ypl: X-ray Crystal Structure of Thrombin Inhibited by Synthetic Cyanopeptide Analogue Ra-1008
  240. 1ypm: X-ray Crystal Structure of Thrombin Inhibited by Synthetic Cyanopeptide Analogue Ra-1014
  241. 1z71: Thrombin and P2 Pyridine N-oxide Inhibitor Complex Structure
  242. 1z8i: Crystal Structure of The Thrombin Mutant G193A Bound to Ppack
  243. 1z8j: Crystal Structure of The Thrombin Mutant G193P Bound to Ppack
  244. 1zgi: Thrombin in Complex with an Oxazolopyridine Inhibitor 21
  245. 1zgv: Thrombin in Complex with an Oxazolopyridine Inhibitor 2
  246. 1zrb: Thrombin in Complex with an Azafluorenyl Inhibitor 23b
  247. 2a0q: Structure of Thrombin in 400 Mm Potassium Chloride
  248. 2a1d: Staphylocoagulase Bound to Bovine Thrombin
  249. 2a2x: Orally Active Thrombin Inhibitors in Complex with Thrombin Inh12
  250. 2a45: Crystal Structure of The Complex between Thrombin and The Central "e" Region of Fibrin
  251. 2afq: 1.9 Angstrom Crytal Structure of Wild-type Human Thrombin in The Sodium Free State
  252. 2v3o: Thrombin with 3-cycle with F
  253. 2v3h: Thrombin with 3-cycle No F
  254. 2ank: Orally Active Thrombin Inhibitors in Complex with Thrombin and an Exosite Decapeptide
  255. 2anm: Ternary Complex of an Orally Active Thrombin Inhibitor with Human Thrombin and a C-terminal Hirudin Derived Exo-sit Inhibitor
  256. 6zv8: Crystal Structure of Thrombin in Complex with Compound51
  257. 6zv7: Crystal Structure of Thrombin in Complex with COMPOUND42B
  258. 6zux: Crystal Structure of Thrombin in Complex with COMPOUND42A
  259. 6zuw: Crystal Structure of Thrombin in Complex with Compound40
  260. 6zuu: Crystal Structure of Thrombin in Complex with Compound30
  261. 6zun: Crystal Structure of Thrombin in Complex with COMPOUND20A
  262. 6zuh: Crystal Structure of Thrombin in Complex with Compound17
  263. 6zug: Crystal Structure of Thrombin in Complex with Compound10
  264. 2uuk: Thrombin-hirugen-gw420128 Ternary Complex at 1.39a Resolution
  265. 2uuj: Thrombin-hirugen-gw473178 Ternary Complex at 1.32a Resolution
  266. 2uuf: Thrombin-hirugen Binary Complex at 1.26a Resolution
  267. 2thf: Structure of Human Alpha-thrombin Y225F Mutant Bound to D- Phe-pro-arg-chloromethylketone
  268. 2spt: Differences in The Metal Ion Structure between Sr-and Ca- Prothrombin Fragment 1
  269. 2b5t: 2.1 Angstrom Structure of a Nonproductive Complex between Antithrombin, Synthetic Heparin Mimetic Sr123781 and Two S195A Thrombin Molecules
  270. 2bdy: Thrombin in Complex with Inhibitor
  271. 2bvr: Human Thrombin Complexed with Fragment-based Small Molecules Occupying The S1 Pocket
  272. 2bvs: Human Thrombin Complexed with Fragment-based Small Molecules Occupying The S1 Pocket
  273. 2bvx: Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-p2-linker
  274. 2r2m: 2-(2-chloro-6-fluorophenyl)acetamides as Potent Thrombin Inhibitors
  275. 2bxt: Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-p2-linker
  276. 2bxu: Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-p2-linker
  277. 2c8w: Thrombin Inhibitors
  278. 2c8x: Thrombin Inhibitors
  279. 2c8y: Thrombin Inhibitors
  280. 2c8z: Thrombin Inhibitors
  281. 2c90: Thrombin Inhibitors
  282. 2c93: Thrombin Inhibitors
  283. 2cf8: Complex of Recombinant Human Thrombin with a Inhibitor
  284. 2cf9: Complex of Recombinant Human Thrombin with a Inhibitor
  285. 2cn0: Complex of Recombinant Human Thrombin with a Designed Inhibitor
  286. 2pgq: Human Thrombin Mutant C191A-C220A in Complex with The Inhibitor Ppack
  287. 2pgb: Inhibitor-free Human Thrombin Mutant C191A-C220A
  288. 2ody: Thrombin-bound Boophilin Displays a Functional and Accessible Reactive-site Loop
  289. 6c2w: Crystal Structure of Human Prothrombin Mutant S101C/A470C
  290. 6bjr: Crystal Structure of Prothrombin Mutant S101C/A470C
  291. 2feq: Orally Active Thrombin Inhibitors
  292. 2fes: Orally Active Thrombin Inhibitors
  293. 2gde: Thrombin in Complex with Inhibitor
  294. 2gp9: Crystal Structure of The Slow Form of Thrombin in a Self- Inhibited Conformation
  295. 5z5x: Hvf18 in Complex with Lps Micelles
  296. 5z5w: Vfr12 in Complex with Lps Micelles
  297. 2h9t: Crystal Structure of Human Alpha-thrombin in Complex with Suramin
  298. 2hgt: Structure of The Hirugen and Hirulog 1 Complexes of Alpha- Thrombin
  299. 2hpp: Structures of The Noncovalent Complexes of Human and Bovine Prothrombin Fragment 2 with Human Ppack-thrombin
  300. 2hpq: Structures of The Noncovalent Complexes of Human and Bovine Prothrombin Fragment 2 with Human Ppack-thrombin
  301. 2hwl: Crystal Structure of Thrombin in Complex with Fibrinogen Gamma' Peptide
  302. 2jh0: Human Thrombin Hirugen Inhibitor Complex.
  303. 2jh5: Human Thrombin Hirugen Inhibitor Complex.
  304. 2jh6: Human Thrombin Hirugen Inhibitor Complex.
  305. 6tkl: Non-cleavable Tsetse Thrombin Inhibitor in Complex with Human Alpha- Thrombin
  306. 6tkj: Tsetse Thrombin Inhibitor in Complex with Human Alpha-thrombin - Tetragonal Form at 7kev
  307. 6tki: Tsetse Thrombin Inhibitor in Complex with Human Alpha-thrombin - Tetragonal Form at 12.7kev
  308. 6tkh: Tsetse Thrombin Inhibitor in Complex with Human Alpha-thrombin - Orthorhombic Form at 7kev
  309. 6tkg: Tsetse Thrombin Inhibitor in Complex with Human Alpha-thrombin - Orthorhombic Form at 12kev
  310. 6t8a: Thrombin in Complex with Diphenyl ((4-carbamimidoylphenyl)((s)-1-((r)- 3-cyclohexyl 2-((phenylmethyl)sulfonamido)propanoyl)pyrrolidine-2- Carboxamido)methyl)phosphonate (mi-492)
  311. 6t89: Thrombin in Complex with (s)-n-(tert-butyl)-4-(3-(3- Carbamimidoylphenyl)-2-((2',4'-dimethoxy-[1,1'-biphenyl])-3- Sulfonamido)propanoyl)piperazine-1-carboxamide (mi-498)
  312. 6t7h: Crystal Structure of Thrombin in Complex with Macrocycle N14-pr4-a
  313. 6t57: Thrombin in Complex with a D-phe-pro-n-amidinopiperidine Derivative
  314. 6t56: Thrombin in Complex with Benzylamine
  315. 6t55: Thrombin in Complex with Methylbenzylamine
  316. 6t54: Thrombin in Complex with a D-phe-pro-2-bromothiophene Derivative
  317. 6t53: Thrombin in Complex with a D-phe-pro-p-benzylamine Derivative
  318. 6t52: Thrombin in Complex with a D-phe-pro-imidazole Derivative
  319. 6t3m: Thrombin in Complex with a D-phe-pro-p-phenol Derivative
  320. 6v64: Crystal Structure of Human Thrombin Bound to Ppack with Tryptophans Replaced by 5-f-tryptophan
  321. 6v5t: Crystal Structure of Human Prethrombin-2 with Tryptophans Replaced by 5-f-tryptophan
  322. 6tdt: Thrombin in Complex with a D-diphe-pro-p-pyridine Derivative
  323. 6t4a: Thrombin in Complex with a D-phe-pro-p-aminopyridine Derivative
  324. 6t3q: Thrombin in Complex with a D-phe-pro-2-aminopyridine Derivative
  325. 3r3g: Structure of Human Thrombin with Residues 145-150 of Murine Thrombin.
  326. 3p6z: Structural Basis of Thrombin Mediated Factor V Activation: Essential Role of The Hirudin-like Sequence Glu666-glu672 for Processing at The Heavy Chain-b Domain Junction
  327. 3pma: 2.2 Angstrom Crystal Structure of The Complex between Bovine Thrombin and Sucrose Octasulfate
  328. 3pmb: 2.9 Angstrom Crystal Structure of Bovine Thrombin in Tetragonal Spacegroup
  329. 3pmh: Mechanism of Sulfotyrosine-mediated Glycoprotein Ib Interaction with Two Distinct Alpha-thrombin Sites
  330. 3qdz: Crystal Structure of The Human Thrombin Mutant D102N in Complex with The Extracellular Fragment of Human Par4.
  331. 3qgn: The Allosteric E*-e Equilibrium Is a Key Property of The Trypsin Fold
  332. 3s7h: Structure of Thrombin Mutant Y225P in The E* Form
  333. 3s7k: Structure of Thrombin Mutant Y225P in The E Form
  334. 3ldx: Discovery and Clinical Evaluation of Rwj-671818, a Thrombin Inhibitor with an Oxyguanidine P1 Motif
  335. 6pxq: Crystal Structure of Human Thrombin Mutant D194A
  336. 6pxj: Crystal Structure of Human Thrombin Mutant I16T
  337. 3p70: Structural Basis of Thrombin-mediated Factor V Activation: Essential Role of The Hirudin-like Sequence Glu666-glu672 for Processing at The Heavy Chain-b Domain Junction
  338. 3tu7: Human Alpha-thrombin Complexed with N-(methylsulfonyl)-d-phenylalanyl- N-((1-carbamimidoyl-4-piperidinyl)methyl)-l-prolinamide (bms-189664)
  339. 3qlp: X-ray Structure of The Complex between Human Alpha Thrombin and a Modified Thrombin Binding Aptamer (mtba)
  340. 3p17: Thrombin Inhibition by Pyridin Derivatives
  341. 6rot: Thrombin in Complex with Mi2105
  342. 3b23: Crystal Structure of Thrombin-variegin Complex: Insights of a Novel Mechanism of Inhibition and Design of Tunable Thrombin Inhibitors
  343. 3po1: Thrombin in Complex with Benzothiazole Guanidine
  344. 3sqe: Crystal Structure of Prethrombin-2 Mutant S195A in The Alternative Form
  345. 3sqh: Crystal Structure of Prethrombin-2 Mutant S195A in The The Open Form
  346. 6px5: Crystal Structure of Human Meizothrombin Desf1 Mutant S195A Bound with Ppack
  347. 3qto: Thrombin Inhibition by Pyridin Derivatives
  348. 3qtv: Thrombin Inhibition by Pyridin Derivatives
  349. 6p9u: Crystal Structure of Human Thrombin Mutant W215A
  350. 3qwc: Thrombin Inhibition by Pyridin Derivatives
  351. 3qx5: Thrombin Inhibition by Pyridin Derivatives
  352. 3u69: Unliganded Wild-type Human Thrombin
  353. 3u8t: Human Thrombin Complexed with D-phe-pro-d-arg-cys
  354. 3rlw: Human Thrombin in Complex with Mi328
  355. 3rly: Human Thrombin in Complex with Mi329
  356. 3rm0: Human Thrombin in Complex with Mi354
  357. 3rm2: Human Thrombin in Complex with Mi003
  358. 3rml: Human Thrombin in Complex with Mi331
  359. 3rmm: Human Thrombin in Complex with Mi332
  360. 3rmn: Human Thrombin in Complex with Mi341
  361. 3rmo: Human Thrombin in Complex with Mi004
  362. 4dt7: Crystal Structure of Thrombin Bound to The Activation Domain Qedqvdprlidgkmtrrgds of Protein C
  363. 3u8o: Human Thrombin Complexed with D-phe-pro-d-arg-d-thr
  364. 3u8r: Human Thrombin Complexed with D-phe-pro-d-arg-ile
  365. 3sha: Human Thrombin in Complex with Ubthr97
  366. 3shc: Human Thrombin in Complex with Ubthr101
  367. 3si3: Human Thrombin in Complex with Ubthr103
  368. 3si4: Human Thrombin in Complex with Ubthr104
  369. 3sv2: Human Thrombin in Complex with Ubthr105
  370. 4ax9: Human Thrombin Complexed with Napsagatran, Ro0466240
  371. 4e7r: Thrombin in Complex with 3-amidinophenylalanine Inhibitor
  372. 4dih: X-ray Structure of The Complex between Human Alpha Thrombin and Thrombin Binding Aptamer in The Presence of Sodium Ions
  373. 4dii: X-ray Structure of The Complex between Human Alpha Thrombin and Thrombin Binding Aptamer in The Presence of Potassium Ions
  374. 3t5f: Human Thrombin in Complex with Mi340
  375. 4ayv: Human Thrombin - Inhibitor Complex
  376. 4ayy: Human Thrombin - Inhibitor Complex
  377. 4az2: Human Thrombin - Inhibitor Complex
  378. 4dy7: Crystal Structures of Protease Nexin-1 in Complex with S195A Thrombin
  379. 3utu: High Affinity Inhibitor of Human Thrombin
  380. 3u98: Human Thrombin in Complex with Mi001
  381. 3u9a: Human Thrombin in Complex with Mi330
  382. 6i51: Thrombin in Complex with Fragment J02
  383. 3uwj: Human Thrombin in Complex with Mi353
  384. 4e05: Anophelin from The Malaria Vector Inhibits Thrombin through a Novel Reverse-binding Mechanism
  385. 4e06: Anophelin from The Malaria Vector Inhibits Thrombin through a Novel Reverse-binding Mechanism
  386. 4bah: Thrombin in Complex with Inhibitor
  387. 4bak: Thrombin in Complex with Inhibitor
  388. 4bam: Thrombin in Complex with Inhibitor
  389. 4ban: Thrombin in Complex with Inhibitor
  390. 4bao: Thrombin in Complex with Inhibitor
  391. 4baq: Thrombin in Complex with Inhibitor
  392. 6hsx: Thrombin in Complex with a D-phe-pro-diaminopyridine Derivative
  393. 6gwe: Crystal Structure of Thrombin Bound to P2 Macrocycle
  394. 4h6s: Crystal Structure of Thrombin Mutant E14EA/D14LA/E18A/S195A
  395. 4h6t: Crystal Structure of Prethrombin-2 Mutant E14EA/D14LA/E18A/S195A
  396. 4hfp: Structure of Thrombin Mutant S195A Bound to The Active Site Inhibitor Argatroban
  397. 6gn7: X-ray Structure of The Complex between Human Alpha Thrombin and Nu172, a Duplex/quadruplex 26-mer Dna Aptamer, in The Presence of Sodium Ions.
  398. 6gbw: Thrombin in Complex with Mi2100 ((s)-n-(2-(aminomethyl)-5- Chlorobenzyl)-1-((benzylsulfonyl)-l-arginyl)pyrrolidine-2- Carboxamide)
  399. 6fjt: 4-chloro-benzamidine in Complex with Thrombin
  400. 4hzh: Structure of Recombinant Gla-domainless Prothrombin Mutant S525A
  401. 6evv: X-ray Structure of The Complex between Human Alpha Thrombin and Nu172, a Duplex/quadruplex 26-mer Dna Aptamer, in The Presence of Potassium Ions.
  402. 6eo9: Crystal Structure of Thrombin in Complex with a Novel Glucose- Conjugated Potent Inhibitor
  403. 6eo8: Crystal Structure of Thrombin in Complex with a Novel Glucose- Conjugated Potent Inhibitor
  404. 6eo7: X-ray Structure of The Complex between Human Alpha-thrombin and Modified 15-mer Dna Aptamer Containing 5-(3-(acetamide-n-yl)-1- Propen-1-yl)-2'-deoxyuridine Residue
  405. 6eo6: X-ray Structure of The Complex between Human Alpha-thrombin and Modified 15-mer Dna Aptamer Containing 5-(3-(2-(1h-indol-3-yl) Acetamide-n-yl)-1-propen-1-yl)-2'-deoxyuridine Residue
  406. 3vxe: Human Alpha-thrombin-bivalirudin Complex at Pd5.0
  407. 3vxf: X/n Joint Refinement of Human Alpha-thrombin-bivalirudin Complex Pd5
  408. 6cym: Reversible Covalent Direct Thrombin Inhibitors
  409. 4boh: Madanins (merops I53) Are Cleaved by Thrombin and Factor Xa
  410. 4ch2: Low-salt Crystal Structure of a Thrombin-gpibalpha Peptide Complex
  411. 4ch8: High-salt Crystal Structure of a Thrombin-gpibalpha Peptide Complex
  412. 4i7y: Crystal Structure of Human Alpha Thrombin in Complex with a 27-mer Aptamer Bound to Exosite II
  413. 4loy: Crystal Structure Analysis of Thrombin in Complex with Compound D57, 5-chlorothiophene-2-carboxylic Acid [(s)-2-[2-methyl-3-(2- Oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1- Yl)- 3-oxopropyl]amide (sar107375)
  414. 4lxb: Crystal Structure Analysis of Thrombin in Complex with Compound D58
  415. 4lz1: X-ray Structure of The Complex between Human Thrombin and The Tba Deletion Mutant Lacking Thymine 12 Nucleobase
  416. 4lz4: X-ray Structure of The Complex between Human Thrombin and The Tba Deletion Mutant Lacking Thymine 3 Nucleobase
  417. 4mlf: Crystal Structure for The Complex of Thrombin Mutant D102N and Hirudin
  418. 4nzq: Crystal Structure of Ca2+-free Prothrombin Deletion Mutant Residues 146-167
  419. 4o03: Crystal Structure of Ca2+ Bound Prothrombin Deletion Mutant Residues 146-167
  420. 4rn6: Structure of Prethrombin-2 Mutant S195A Bound to The Active Site Inhibitor Argatroban
  421. 5to3: Crystal Structure of Thrombin Mutant W215A/E217A Fused to Egf456 of Thrombomodulin via a 31-residue Linker and Bound to Ppack
  422. 5nhu: Human Alpha Thrombin Complexed with Anopheles Gambiae Ce5 Anticoagulant
  423. 5mm6: Thrombin Mutant A190S in Complex with (s)-1-(d-phenylalanyl)-n-(4- Carbamimidoylbenzyl)pyrrolidine-2-carboxamide
  424. 5mls: Thrombin Mutant A190S in Complex with (s)-1-(d-phenylalanyl)-n-(3- Chlorobenzyl)pyrrolidine-2-carboxamide
  425. 5mjt: Thrombin Mutant A190S in Complex with (s) -1 - ((r) -2-amino-3,3- Diphenylpropanoyl) -n- (3-chlorobenzyl) Pyrrolidine-2-carboxamide
  426. 5lpd: Thrombin in Complex with (s)-1-((r)-2-amino-3-cyclohexylpropanoyl)-n- (2-(aminomethyl)-5-chlorobenzyl) Pyrrolidine-2-carboxamide
  427. 5lce: Thrombin in Complex with (s)-1-((r)-2-amino-3-cyclohexylpropanoyl)-n- (5-chloro-2-(hydroxymethyl)benzy L)pyrrolidine-2-carboxamide
  428. 5l6n: Disulfated Madanin-thrombin Complex
  429. 5jzy: Thrombin in Complex with (s)-1-((r)-2-amino-3-cyclohexylpropanoyl)-n- (4-carbamimidoylbenzyl)pyrrolidine-2-carboxamide
  430. 5jfd: Thrombin in Complex with (s)-n-(2-(aminomethyl)-5-chlorobenzyl)-1- ((benzylsulfonyl)-d-arginyl)pyrrolidine-2-carboxamide
  431. 5jdu: Crystal Structure for Human Thrombin Mutant D189A
  432. 5gim: Crystal Structure of Thrombin-avathrin Complex
  433. 5ew2: Human Thrombin Sandwiched between Two Dna Aptamers: Hd22 and Hd1- Deltat12
  434. 5ew1: Human Thrombin Sandwiched between Two Dna Aptamers: Hd22 and Hd1- Deltat3
  435. 5edm: Crystal Structure of Prothrombin Deletion Mutant Residues 154-167 ( Form I )
  436. 5edk: Crystal Structure of Prothrombin Deletion Mutant Residues 146-167 ( Form II ).
  437. 5e8e: Crystal Structure of Thrombin Bound to an Exosite 1-specific Iga Fab
  438. 5do4: Thrombin-rna Aptamer Complex
  439. 5cmx: X-ray Structure of The Complex between Human Alpha Thrombin and a Duplex/quadruplex 31-mer Dna Aptamer
  440. 5ahg: Thrombin in Complex with ((4-chlorophenyl)sulfamoyl))diemethylamine
  441. 5afz: Thrombin in Complex with (2r)-2-(benzylsulfonylamino)-n-(2-( (4-carbamimidoylphenyl)methylamino)-2-oxo-propyl)-3-phenyl- Propanamide
  442. 5afy: Thrombin in Complex with 3-chloro-benzamide
  443. 5af9: Thrombin in Complex with 4-methoxy-n-(2-pyridinyl)benzamide
  444. 5a2m: Thrombin Inhibitor
  445. 4rkj: Crystal Structure of Thrombin Mutant S195T (free Form)
  446. 4rko: Crystal Structure of Thrombin Mutant S195T Bound with Ppack
  447. 4yes: Thrombin in Complex with (s)-(4-chloro-2-((1-(5-methyl-1h-pyrrole-2- Carbonyl)pyrrolidine-2-carboxamido)methyl)phenyl)methanaminium
  448. 4ud9: Thrombin in Complex with 5-chlorothiophene-2-carboxamide
  449. 4udw: Thrombin in Complex with 1-(2r)-2-amino-3-phenyl-propanoyl-n-(2, 5dichlorophenyl)methylpyrrolidine-2-carboxamide
  450. 4ue7: Thrombin in Complex with 1-amidinopiperidine
  451. 4ueh: Thrombin in Complex with Benzamidine
  452. 4ufd: Thrombin in Complex with 4-(((1-((2s)-1-((2r)-2-( Benzylsulfonylamino)-3-phenyl-propanoyl)pyrrolidin-2-yl)-1- Oxo-ethyl)amino)methyl)benzamidine
  453. 4ufe: Thrombin in Complex with (2r)-2-(benzylsulfonylamino)-n-(2-( (4-carbamimidoylphenyl)methylamino)-2-oxo-butyl)-3-phenyl- Propanamide
  454. 4uff: Thrombin in Complex with (2r)-2-(benzylsulfonylamino)-n-(2-( (4-carbamimidoylphenyl)methylamino)-2-oxo-ethyl)-n-methyl- 3-phenyl-propanamide
  455. 4ufg: Thrombin in Complex with (2r)-2-(benzylsulfonylamino)-n-(( 1s)-2-((4-carbamimidoylphenyl)methylamino)-1-methyl-2-oxo- Ethyl)-n-methyl-3-phenyl-propanamide Ethane
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