EC 3.4.21.5 - thrombin

3D structures of EC 3.4.21.5 - thrombin in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1a0h: The X-ray Crystal Structure of Ppack-meizothrombin Desf1: Kringle/thrombin and Carbohydrate/kringle/thrombin Interactions and Location of The Linker Chain
2. 1a2c: Structure of Thrombin Inhibited by Aeruginosin298-a from a Blue-green Alga
3. 1a3b: Complex of Human Alpha-thrombin with The Bifunctional Boronate Inhibitor Borolog1
4. 1a3e: Complex of Human Alpha-thrombin with The Bifunctional Boronate Inhibitor Borolog2
5. 1a46: Thrombin Complexed with Hirugen and a Beta-strand Mimetic Inhibitor
6. 1a4w: Crystal Structures of Thrombin with Thiazole-containing Inhibitors: Probes of The S1' Binding Site
7. 1a5g: Human Thrombin Complexed with Novel Synthetic Peptide Mimetic Inhibitor and Hirugen
8. 1a61: Thrombin Complexed with a Beta-mimetic Thiazole-containing Inhibitor
9. 1abi: Structure of The Hirulog 3-thrombin Complex and Nature of The S' Subsites of Substrates and Inhibitors
10. 1abj: Structure of The Hirulog 3-thrombin Complex and Nature of The S' Subsites of Substrates and Inhibitors
11. 1ad8: Complex of Thrombin with and Inhibitor Containing a Novel P1 Moiety
12. 1ae8: Human Alpha-thrombin Inhibition by Eoc-d-phe-pro-azalys-onp
13. 1afe: Human Alpha-thrombin Inhibition by Cbz-pro-azalys-onp
14. 1aht: Crystal Structure of Human Alpha-thrombin Complexed with Hirugen and P-amidinophenylpyruvate) at 1.6 Angstroms Resolution
15. 1ai8: Human Alpha-thrombin Ternary Complex with The Exosite Inhibitor Hirugen and Active Site Inhibitor PHCH2OCO-D-DPA- Pro-borompg
16. 1aix: Human Alpha-thrombin Ternary Complex with Exosite Inhibitor Hirugen and Active Site Inhibitor PHCH2OCO-D-DPA-PRO- Boroval
17. 1avg: Thrombin Inhibitor from Triatoma Pallidipennis
18. 1awf: Novel Covalent Thrombin Inhibitor from Plant Extract
19. 1awh: Novel Covalent Thrombin Inhibitor from Plant Extract
20. 1ay6: Thrombin Inhibitor from Theonalla, Cyclotheanamide-based Macrocyclic Tripeptide Motif
21. 1b5g: Human Thrombin Complexed with Novel Synthetic Peptide Mimetic Inhibitor and Hirugen
22. 1b7x: Structure of Human Alpha-thrombin Y225I Mutant Bound to D- Phe-pro-arg-chloromethylketone
23. 1ba8: Thrombin Inhibitor with a Rigid Tripeptidyl Aldehydes
24. 1bb0: Thrombin Inhibitors with Rigid Tripeptidyl Aldehydes
25. 1bbr: The Structure of Residues 7-16 of The a Alpha Chain of Human Fibrinogen Bound to Bovine Thrombin at 2.3 Angstroms Resolution
26. 1bcu: Alpha-thrombin Complexed with Hirugen and Proflavin
27. 1bhx: X-ray Structure of The Complex of Human Alpha Thrombin with The Inhibitor Sdz 229-357
28. 1bmm: Human Alpha-thrombin Complexed with [s-(r*,r*)]-4- [(aminoiminomethyl)amino]-n-[[1-[3-hydroxy-2-[(2- Naphthalenylsulfonyl)amino]-1-oxopropyl]-2-pyrrolidinyl] Methyl]butanamide (bms-186282)
29. 1bmn: Human Alpha-thrombin Complexed with [s-(r*,r*)]-1- (aminoiminomethyl)-n-[[1-[n-[(2-naphthalenylsulfonyl)-l- Seryl]-pyrrolidinyl]methyl]-3-piperidenecarboxamide (bms- 189090)
30. 1bth: Structure of Thrombin Complexed with Bovine Pancreatic Trypsin Inhibitor
31. 1c1u: Recruiting Zinc to Mediate Potent, Specific Inhibition of Serine Proteases
32. 1c1v: Recruiting Zinc to Mediate Potent, Specific Inhibition of Serine Proteases
33. 1c1w: Recruiting Zinc to Mediate Potent, Specific Inhibition of Serine Proteases
34. 1c4u: Selective Non Electrophilic Thrombin Inhibitors with Cyclohexyl Moieties.
35. 1c4v: Selective Non Electrophilic Thrombin Inhibitors with Cyclohexyl Moieties.
36. 1c4y: Selective Non-electrophilic Thrombin Inhibitors
37. 1c5l: Structural Basis for Selectivity of a Small Molecule, S1- Binding, Sub-micromolar Inhibitor of Urokinase Type Plasminogen Activator
38. 1c5n: Structural Basis for Selectivity of a Small Molecule, S1- Binding, Sub-micromolar Inhibitor of Urokinase Type Plasminogen Activator
39. 1c5o: Structural Basis for Selectivity of a Small Molecule, S1- Binding, Sub-micromolar Inhibitor of Urokinase Type Plasminogen Activator
40. 1ca8: Thrombin Inhibitors with Rigid Tripeptidyl Aldehydes
41. 1d3d: Crystal Structure of Human Alpha Thrombin in Complex with Benzothiophene Inhibitor 4
42. 1d3p: Crystal Structure of Human Aplha-thrombin in Complex with Benzo[b]thiophene Inhibitor 3
43. 1d3q: Crystal Structure of Human Alpha Thrombin in Complex with Benzo[b]thiophene Inhibitor 2
44. 1d3t: Crystal Structure of Human Alpha Thrombin in Complex with Benzo[b]thiophene Inhibitor 1
45. 1d4p: Crystal Structure of Human Alpha Thrombin in Complex with 5- Amidinoindole-4-benzylpiperidine Inhibitor
46. 1d6w: Structure of Thrombin Complexed with Selective Non- Electrophilic Inhibitors Having Cyclohexyl Moieties at P1
47. 1d9i: Structure of Thrombin Complexed with Selective Non- Electophilic Inhibitors Having Cyclohexyl Moieties at P1
48. 1de7: Interaction of Factor XIII Activation Peptide with Alpha- Thrombin: Crystal Structure of The Enzyme-substrate Complex
49. 1dit: Complex of a Divalent Inhibitor with Thrombin
50. 1doj: Crystal Structure of Human Alpha-thrombin*rwj-51438 Complex at 1.7 a
51. 1dwb: Crystallographic Analysis at 3.0-angstroms Resolution of The Binding to Human Thrombin of Four Active Site-directed Inhibitors
52. 1dwc: Crystallographic Analysis at 3.0-angstroms Resolution of The Binding to Human Thrombin of Four Active Site-directed Inhibitors
53. 1dwd: Crystallographic Analysis at 3.0-angstroms Resolution of The Binding to Human Thrombin of Four Active Site-directed Inhibitors
54. 1dwe: Crystallographic Analysis at 3.0-angstroms Resolution of The Binding to Human Thrombin of Four Active Site-directed Inhibitors
55. 1dx5: Crystal Structure of The Thrombin-thrombomodulin Complex
56. 1e0f: Crystal Structure of The Human Alpha-thrombin-haemadin Complex: an Exosite Ii-binding Inhibitor
57. 1eb1: Complex Structure of Human Thrombin with N-methyl-arginine Inhibitor
58. 1eoj: Design of P1' and P3' Residues of Trivalent Thrombin Inhibitors and Their Crystal Structures
59. 1eol: Design of P1' and P3' Residues of Trivalent Thrombin Inhibitors and Their Crystal Structures
60. 1etr: Refined 2.3 Angstroms X-ray Crystal Structure of Bovine Thrombin Complexes Formed with The Benzamidine and Arginine-based Thrombin Inhibitors Napap, 4-tapap and Mqpa: a Starting Point for Improving Antithrombotics
61. 1ets: Refined 2.3 Angstroms X-ray Crystal Structure of Bovine Thrombin Complexes Formed with The Benzamidine and Arginine-based Thrombin Inhibitors Napap, 4-tapap and Mqpa: a Starting Point for Improving Antithrombotics
62. 1ett: Refined 2.3 Angstroms X-ray Crystal Structure of Bovine Thrombin Complexes Formed with The Benzamidine and Arginine-based Thrombin Inhibitors Napap, 4-tapap and Mqpa: a Starting Point for Improving Antithrombotics
63. 1fpc: Active Site Mimetic Inhibition of Thrombin
64. 1fph: The Interaction of Thrombin with Fibrinogen: a Structural Basis for Its Specificity
65. 1g30: Thrombin Inhibitor Complex
66. 1g32: Thrombin Inhibitor Complex
67. 1g37: Crystal Structure of Human Alpha-thrombin Complexed with Bch-10556 and Exosite-directed Peptide
68. 1ghv: A Novel Serine Protease Inhibition Motif Involving a Multi- Centered Short Hydrogen Bonding Network at The Active Site
69. 1ghw: A Novel Serine Protease Inhibition Motif Involving a Multi- Centered Short Hydrogen Bonding Network at The Active Site
70. 1ghx: A Novel Serine Protease Inhibition Motif Involving a Multi- Centered Short Hydrogen Bonding Network at The Active Site
71. 1ghy: A Novel Serine Protease Inhibition Motif Involving a Multi- Centered Short Hydrogen Bonding Network at The Active Site
72. 1gj4: Selectivity at S1, H2O Displacement, Upa, Tpa, Ser190/ala190 Protease, Structure-based Drug Design
73. 1gj5: Selectivity at S1, H2O Displacement, Upa, Tpa, Ser190/ala190 Protease, Structure-based Drug Design
74. 1h8d: X-ray Structure of The Human Alpha-thrombin Complex with a Tripeptide Phosphonate Inhibitor.
75. 1h8i: X-ray Crystal Structure of Human Alpha-thrombin with a Tripeptide Phosphonate Inhibitor.
76. 1hag: The Isomorphous Structures of Prethrombin2, Hirugen-and Ppack-thrombin: Changes Accompanying Activation and Exosite Binding to Thrombin
77. 1hah: The Isomorphous Structures of Prethrombin2, Hirugen-and Ppack-thrombin: Changes Accompanying Activation and Exosite Binding to Thrombin
78. 1hai: The Isomorphous Structures of Prethrombin2, Hirugen-and Ppack-thrombin: Changes Accompanying Activation and Exosite Binding to Thrombin
79. 1hao: Complex of Human Alpha-thrombin with a 15mer Oligonucleotide Ggttggtgtggttgg (based on Nmr Model of Dna
80. 1hap: Complex of Human Alpha-thrombin with a 15mer Oligonucleotide Ggttggtgtggttgg (based on X-ray Model of Dna)
81. 1hbt: Human Alpha-thrombin Complexed with a Peptidyl Pyridinium Methyl Ketone Containing Bivalent Inhibitor
82. 1hdt: Structure of a Retro-binding Peptide Inhibitor Complexed with Human Alpha-thrombin
83. 1hgt: Structure of The Hirugen and Hirulog 1 Complexes of Alpha- Thrombin
84. 1hrt: The Structure of a Complex of Bovine Alpha-thrombin and Recombinant Hirudin at 2.8 Angstroms Resolution
85. 1hut: The Structure of Alpha-thrombin Inhibited by a 15-mer Single-stranded Dna Aptamer
86. 1hxe: Serine Protease
87. 1hxf: Human Thrombin Complex with Hirudin Variant
88. 1id5: Crystal Structure of Bovine Thrombin Complex with Protease Inhibitor Ecotin
89. 1ihs: Crystal Structure of The Complex of Human Alpha-thrombin and Non-hydrolyzable Bifunctional Inhibitors, Hirutonin-2 and Hirutonin-6
90. 1iht: Crystal Structure of The Complex of Human Alpha-thrombin and Non-hydrolyzable Bifunctional Inhibitors, Hirutonin-2 and Hirutonin-6
91. 1jmo: Crystal Structure of The Heparin Cofactor II-S195A Thrombin Complex
92. 1jwt: Crystal Structure of Thrombin in Complex with a Novel Bicyclic Lactam Inhibitor
93. 1k21: Human Thrombin-inhibitor Complex
94. 1k22: Human Thrombin-inhibitor Complex
95. 8kme: Crystal Structure of Human Alpha-thrombin Inhibited with Sel2770.
96. 7kme: Crystal Structure of Human Alpha-thrombin Inhibited with Sel2711.
97. 5gds: Hirunorms Are True Hirudin Mimetics. The Crystal Structure of Human Alpha-thrombin:hirunorm V Complex
98. 4thn: The Crystal Structure of Alpha-thrombin-hirunorm IV Complex Reveals a Novel Specificity Site Recognition Mode.
99. 4htc: The Refined Structure of The Hirudin-thrombin Complex
100. 1kts: Thrombin Inhibitor Complex
101. 1ktt: Thrombin Inhibitor Complex
102. 1lhc: Human Alpha-thrombin Complexed with Ac-(d)phe-pro-boroarg-oh
103. 1lhd: Human Alpha-thrombin Complexed with Ac-(d)phe-pro-borolys-oh
104. 1lhe: Human Alpha-thrombin Complexed with Ac-(d)phe-pro-boro-n- Butyl-amidino-glycine-oh
105. 1lhf: Human Alpha-thrombin Complexed with Ac-(d)phe-pro-boro- Homolys-oh
106. 1lhg: Human Alpha-thrombin Complexed with Ac-(d)phe-pro- Boroornithine-oh
107. 3nxp: Crystal Structure of Human Prethrombin-1
108. 1mh0: Crystal Structure of The Anticoagulant Slow Form of Thrombin
109. 1mkw: The Co-crystal Structure of Unliganded Bovine Alpha- Thrombin and Prethrombin-2: Movement of The Yppw Segment and Active Site Residues upon Ligand Binding
110. 1mkx: The Co-crystal Structure of Unliganded Bovine Alpha- Thrombin and Prethrombin-2: Movement of The Yppw Segment and Active Site Residues upon Ligand Binding
111. 1mu6: Crystal Structure of Thrombin in Complex with L-378,622
112. 1mu8: Thrombin-hirugen_l-378,650
113. 1mue: Thrombin-hirugen-l405,426
114. 3lu9: Crystal Structure of Human Thrombin Mutant S195A in Complex with The Extracellular Fragment of Human Par1
115. 1nl1: Bovine Prothrombin Fragment 1 in Complex with Calcium Ion
116. 1nl2: Bovine Prothrombin Fragment 1 in Complex with Calcium and Lysophosphotidylserine
117. 1nm6: Thrombin in Complex with Selective Macrocyclic Inhibitor at 1.8a
118. 1no9: Design of Weakly Basic Thrombin Inhibitors Incorporating Novel P1 Binding Functions: Molecular and X-ray Crystallographic Studies.
119. 1nrn: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
120. 1nro: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
121. 1nrp: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
122. 1nrq: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
123. 1nrr: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
124. 1nrs: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
125. 1nt1: Thrombin in Complex with Selective Macrocyclic Inhibitor
126. 1nu7: Staphylocoagulase-thrombin Complex
127. 1nu9: Staphylocoagulase-prethrombin-2 Complex
128. 1ny2: Human Alpha Thrombin Inhibited by Rppgf and Hirugen
129. 1nzq: D-phe-pro-arg-type Thrombin Inhibitor
130. 1o0d: Human Thrombin Complexed with a D-phe-pro-arg-type Inhibitor and a C-terminal Hirudin Derived Exo-site Inhibitor
131. 1o2g: Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors
132. 1o5g: Dissecting and Designing Inhibitor Selectivity Determinants at The S1 Site Using an Artificial Ala190 Protease (ala190 Upa)
133. 1ook: Crystal Structure of The Complex of Platelet Receptor Gpib- Alpha and Human Alpha-thrombin
134. 3k65: Crystal Structure of Prethombin-2/fragment-2 Complex
135. 3jz2: Crystal Structure of Human Thrombin Mutant N143P in E* Form
136. 3jz1: Crystal Structure of Human Thrombin Mutant N143P in E:na+ Form
137. 1oyt: Complex of Recombinant Human Thrombin with a Designed Fluorinated Inhibitor
138. 1p8v: Crystal Structure of The Complex of Platelet Receptor Gpib- Alpha and Alpha-thrombin at 2.6a
139. 1ppb: The Refined 1.9 Angstroms Crystal Structure of Human Alpha- Thrombin: Interaction with D-phe-pro-arg Chloromethylketone and Significance of The Tyr-pro-pro-trp Insertion Segment
140. 1qbv: Crystal Structure of Thrombin Complexed with an Guanidine- Mimetic Inhibitor
141. 3htc: The Structure of a Complex of Recombinant Hirudin and Human Alpha-thrombin
142. 1qhr: Novel Covalent Active Site Thrombin Inhibitors
143. 1qj1: Novel Covalent Active Site Thrombin Inhibitors
144. 1qj6: Novel Covalent Active Site Thrombin Inhibitors
145. 1qj7: Novel Covalent Active Site Thrombin Inhibitors
146. 3hkj: Crystal Structure of Human Thrombin Mutant W215A/E217A in Complex with The Extracellular Fragment of Human Par1
147. 3hki: Crystal Structure of Murine Thrombin Mutant W215A/E217A in Complex with The Extracellular Fragment of Human Par1
148. 3hk6: Crystal Structure of Murine Thrombin Mutant W215A/E217A (two Molecules in The Asymmetric Unit)
149. 3hk3: Crystal Structure of Murine Thrombin Mutant W215A/E217A (one Molecule in The Asymmetric Unit)
150. 3hat: Active Site Mimetic Inhibition of Thrombin
151. 1rd3: 2.5a Structure of Anticoagulant Thrombin Variant E217K
152. 1riw: Thrombin in Complex with Natural Product Inhibitor Oscillarin
153. 3gis: Crystal Structure of Na-free Thrombin in Complex with Thrombomodulin
154. 3gic: Structure of Thrombin Mutant Delta(146-149e) in The Free Form
155. 1sb1: Novel Non-covalent Thrombin Inhibitors Incorporating P1 4,5, 6,7-tetrahydrobenzothiazole Arginine Side Chain Mimetics
156. 1sfq: Fast Form of Thrombin Mutant R(77a)a Bound to Ppack
157. 1sg8: Crystal Structure of The Procoagulant Fast Form of Thrombin
158. 1sgi: Crystal Structure of The Anticoagulant Slow Form of Thrombin
159. 1shh: Slow Form of Thrombin Bound with Ppack
160. 1sl3: Crystal Structue of Thrombin in Complex with a Potent P1 Heterocycle-aryl Based Inhibitor
161. 1sr5: Antithrombin-anhydrothrombin-heparin Ternary Complex Structure
162. 3f68: Thrombin Inhibition
163. 1t4u: Crystal Structure Analysis of a Novel Oxyguanidine Bound to Thrombin
164. 1t4v: Crystal Structure Analysis of a Novel Oxyguanidine Bound to Thrombin
165. 3eq0: Thrombin Inhibitor
166. 1ta2: Crystal Structure of Thrombin in Complex with Compound 1
167. 1ta6: Crystal Structure of Thrombin in Complex with Compound 14b
168. 1tb6: 2.5a Crystal Structure of The Antithrombin-thrombin-heparin Ternary Complex
169. 1tbq: Crystal Structure of Insect Derived Double Domain Kazal Inhibitor Rhodniin in Complex with Thrombin
170. 1tbr: Crystal Structure of Insect Derived Double Domain Kazal Inhibitor Rhodniin in Complex with Thrombin
171. 1tbz: Human Thrombin with Active Site N-methyl-d Phenylalanyl-n- [5-(aminoiminomethyl)amino]-1-{{benzothiazolyl)carbonyl] Butyl]-l-prolinamide Trifluroacetate and Exosite-hirugen
172. 1thp: Structure of Human Alpha-thrombin Y225P Mutant Bound to D- Phe-pro-arg-chloromethylketone
173. 1thr: Structures of Thrombin Complexes with a Designed and a Natural Exosite Inhibitor
174. 1ths: Structures of Thrombin Complexes with a Designed and a Natural Exosite Inhibitor
175. 3egk: Knoble Inhibitor
176. 3ee0: Crystal Structure of The W215A/E217A Mutant of Human Thrombin (space Group P2(1)2(1)2(1))
177. 3edx: Crystal Structure of The W215A/E217A Mutant of Murine Thrombin
178. 1tmb: Molecular Basis for The Inhibition of Human Alpha-thrombin by The Macrocyclic Peptide Cyclotheonamide a
179. 1tmt: Changes in Interactions in Complexes of Hirudin Derivatives and Human Alpha-thrombin due to Different Crystal Forms
180. 1tmu: Changes in Interactions in Complexes of Hirudin Derivatives and Human Alpha-thrombin due to Different Crystal Forms
181. 1toc: Structure of Serine Proteinase
182. 3e6p: Crystal Structure of Human Meizothrombin Desf1
183. 1tom: Alpha-thrombin Complexed with Hirugen
184. 1tq0: Crystal Structure of The Potent Anticoagulant Thrombin Mutant W215A/E217A in Free Form
185. 1tq7: Crystal Structure of The Anticoagulant Thrombin Mutant W215A/E217A Bound to Ppack
186. 1twx: Crystal Structure of The Thrombin Mutant D221A/D222K
187. 3dux: Understanding Thrombin Inhibition
188. 3dt0: Understanding Thrombin Inhibition
189. 3dhk: Bisphenylic Thrombin Inhibitors
190. 1ucy: Thrombin Complexed with Fibrinopeptide a Alpha (residues 7- 19). Three Complexes, One with Epsilon-thrombin and Two with Alpha-thrombin
191. 3dd2: Crystal Structure of an Rna Aptamer Bound to Human Thrombin
192. 3da9: Crystal Structure of Thrombin in Complex with Inhibitor
193. 3d49: Thrombin Inhibition
194. 1uma: Alpha-thrombin (hirugen) Complexed with Na-(n,n- Dimethylcarbamoyl)-alpha-azalysine
195. 1uvs: Bovine Thrombin--bm51.1011 Complex
196. 1uvt: Bovine Thrombin--bm14.1248 Complex
197. 1uvu: Bovine Thrombin--bm12.1700 Complex
198. 1vit: Thrombin:hirudin 51-65 Complex
199. 3c27: Cyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors
200. 3c1k: Crystal Structure of Thrombin in Complex with Inhibitor 15
201. 3bv9: Structure of Thrombin Bound to The Inhibitor Fm19
202. 1vr1: Specifity for Plasminogen Activator Inhibitor-1
203. 1vzq: Complex of Thrombin with Designed Inhibitor 7165
204. 3biv: Human Thrombin-in Complex with Ub-thr11
205. 3biu: Human Thrombin-in Complex with Ub-thr10
206. 3bf6: Thrombin:suramin Complex
207. 3bei: Crystal Structure of The Slow Form of Thrombin in a Self_inhibited Conformation
208. 3bef: Crystal Structure of Thrombin Bound to The Extracellular Fragment of Par1
209. 1w7g: Alpha-thrombin Complex with Sulfated Hirudin (residues 54- 65) and L-arginine Template Inhibitor Cs107
210. 3b9f: 1.6 a Structure of The Pci-thrombin-heparin Complex
211. 1way: Active Site Thrombin Inhibitors
212. 1wbg: Active Site Thrombin Inhibitors
213. 2zo3: Bisphenylic Thrombin Inhibitors
214. 2znk: Thrombin Inhibition
215. 2ziq: Thrombin Inhibition
216. 2zi2: Thrombin Inhibition
217. 2zhw: Exploring Thrombin S3 Pocket
218. 2zhq: Thrombin Inhibition
219. 2zhf: Exploring Thrombin S3 Pocket
220. 2zhe: Exploring Thrombin S3 Pocket
221. 2zgx: Thrombin Inhibition
222. 2zgb: Thrombin Inhibition
223. 2zg0: Exploring Thrombin S3 Pocket
224. 2zfr: Exploring Thrombin S3 Pocket
225. 2zfq: Exploring Thrombin S3 Pocket
226. 2zfp: Thrombin Inibition
227. 2zff: Exploring Thrombin S1-pocket
228. 2zf0: Exploring Thrombin S1 Pocket
229. 2zdv: Exploring Thrombin S1 Pocket
230. 2zda: Exploring Thrombin S1 Pocket
231. 2zc9: Thrombin in Complex with Inhibitor
232. 1xm1: Nonbasic Thrombin Inhibitor Complex
233. 1xmn: Crystal Structure of Thrombin Bound to Heparin
234. 1ycp: The Crystal Structure of Fibrinogen-aa Peptide 1-23 (F8Y) Bound to Bovine Thrombin Explains Why The Mutation of Phe- 8 to Tyrosine Strongly Inhibits Normal Cleavage at Arginine-16
235. 1ype: Thrombin Inhibitor Complex
236. 1ypg: Thrombin Inhibitor Complex
237. 1ypj: Thrombin Inhibitor Complex
238. 1ypk: Thrombin Inhibitor Complex
239. 1ypl: X-ray Crystal Structure of Thrombin Inhibited by Synthetic Cyanopeptide Analogue Ra-1008
240. 1ypm: X-ray Crystal Structure of Thrombin Inhibited by Synthetic Cyanopeptide Analogue Ra-1014
241. 1z71: Thrombin and P2 Pyridine N-oxide Inhibitor Complex Structure
242. 1z8i: Crystal Structure of The Thrombin Mutant G193A Bound to Ppack
243. 1z8j: Crystal Structure of The Thrombin Mutant G193P Bound to Ppack
244. 1zgi: Thrombin in Complex with an Oxazolopyridine Inhibitor 21
245. 1zgv: Thrombin in Complex with an Oxazolopyridine Inhibitor 2
246. 1zrb: Thrombin in Complex with an Azafluorenyl Inhibitor 23b
247. 2a0q: Structure of Thrombin in 400 Mm Potassium Chloride
248. 2a1d: Staphylocoagulase Bound to Bovine Thrombin
249. 2a2x: Orally Active Thrombin Inhibitors in Complex with Thrombin Inh12
250. 2a45: Crystal Structure of The Complex between Thrombin and The Central "e" Region of Fibrin
251. 2afq: 1.9 Angstrom Crytal Structure of Wild-type Human Thrombin in The Sodium Free State
252. 2v3o: Thrombin with 3-cycle with F
253. 2v3h: Thrombin with 3-cycle No F
254. 2ank: Orally Active Thrombin Inhibitors in Complex with Thrombin and an Exosite Decapeptide
255. 2anm: Ternary Complex of an Orally Active Thrombin Inhibitor with Human Thrombin and a C-terminal Hirudin Derived Exo-sit Inhibitor
256. 6zv8: Crystal Structure of Thrombin in Complex with Compound51
257. 6zv7: Crystal Structure of Thrombin in Complex with COMPOUND42B
258. 6zux: Crystal Structure of Thrombin in Complex with COMPOUND42A
259. 6zuw: Crystal Structure of Thrombin in Complex with Compound40
260. 6zuu: Crystal Structure of Thrombin in Complex with Compound30
261. 6zun: Crystal Structure of Thrombin in Complex with COMPOUND20A
262. 6zuh: Crystal Structure of Thrombin in Complex with Compound17
263. 6zug: Crystal Structure of Thrombin in Complex with Compound10
264. 2uuk: Thrombin-hirugen-gw420128 Ternary Complex at 1.39a Resolution
265. 2uuj: Thrombin-hirugen-gw473178 Ternary Complex at 1.32a Resolution
266. 2uuf: Thrombin-hirugen Binary Complex at 1.26a Resolution
267. 2thf: Structure of Human Alpha-thrombin Y225F Mutant Bound to D- Phe-pro-arg-chloromethylketone
268. 2spt: Differences in The Metal Ion Structure between Sr-and Ca- Prothrombin Fragment 1
269. 2b5t: 2.1 Angstrom Structure of a Nonproductive Complex between Antithrombin, Synthetic Heparin Mimetic Sr123781 and Two S195A Thrombin Molecules
270. 2bdy: Thrombin in Complex with Inhibitor
271. 2bvr: Human Thrombin Complexed with Fragment-based Small Molecules Occupying The S1 Pocket
272. 2bvs: Human Thrombin Complexed with Fragment-based Small Molecules Occupying The S1 Pocket
273. 2bvx: Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-p2-linker
274. 2r2m: 2-(2-chloro-6-fluorophenyl)acetamides as Potent Thrombin Inhibitors
275. 2bxt: Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-p2-linker
276. 2bxu: Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-p2-linker
277. 2c8w: Thrombin Inhibitors
278. 2c8x: Thrombin Inhibitors
279. 2c8y: Thrombin Inhibitors
280. 2c8z: Thrombin Inhibitors
281. 2c90: Thrombin Inhibitors
282. 2c93: Thrombin Inhibitors
283. 2cf8: Complex of Recombinant Human Thrombin with a Inhibitor
284. 2cf9: Complex of Recombinant Human Thrombin with a Inhibitor
285. 2cn0: Complex of Recombinant Human Thrombin with a Designed Inhibitor
286. 2pgq: Human Thrombin Mutant C191A-C220A in Complex with The Inhibitor Ppack
287. 2pgb: Inhibitor-free Human Thrombin Mutant C191A-C220A
288. 2ody: Thrombin-bound Boophilin Displays a Functional and Accessible Reactive-site Loop
289. 6c2w: Crystal Structure of Human Prothrombin Mutant S101C/A470C
290. 6bjr: Crystal Structure of Prothrombin Mutant S101C/A470C
291. 2feq: Orally Active Thrombin Inhibitors
292. 2fes: Orally Active Thrombin Inhibitors
293. 2gde: Thrombin in Complex with Inhibitor
294. 2gp9: Crystal Structure of The Slow Form of Thrombin in a Self- Inhibited Conformation
295. 5z5x: Hvf18 in Complex with Lps Micelles
296. 5z5w: Vfr12 in Complex with Lps Micelles
297. 2h9t: Crystal Structure of Human Alpha-thrombin in Complex with Suramin
298. 2hgt: Structure of The Hirugen and Hirulog 1 Complexes of Alpha- Thrombin
299. 2hpp: Structures of The Noncovalent Complexes of Human and Bovine Prothrombin Fragment 2 with Human Ppack-thrombin
300. 2hpq: Structures of The Noncovalent Complexes of Human and Bovine Prothrombin Fragment 2 with Human Ppack-thrombin
301. 2hwl: Crystal Structure of Thrombin in Complex with Fibrinogen Gamma' Peptide
302. 2jh0: Human Thrombin Hirugen Inhibitor Complex.
303. 2jh5: Human Thrombin Hirugen Inhibitor Complex.
304. 2jh6: Human Thrombin Hirugen Inhibitor Complex.
305. 6tkl: Non-cleavable Tsetse Thrombin Inhibitor in Complex with Human Alpha- Thrombin
306. 6tkj: Tsetse Thrombin Inhibitor in Complex with Human Alpha-thrombin - Tetragonal Form at 7kev
307. 6tki: Tsetse Thrombin Inhibitor in Complex with Human Alpha-thrombin - Tetragonal Form at 12.7kev
308. 6tkh: Tsetse Thrombin Inhibitor in Complex with Human Alpha-thrombin - Orthorhombic Form at 7kev
309. 6tkg: Tsetse Thrombin Inhibitor in Complex with Human Alpha-thrombin - Orthorhombic Form at 12kev
310. 6t8a: Thrombin in Complex with Diphenyl ((4-carbamimidoylphenyl)((s)-1-((r)- 3-cyclohexyl 2-((phenylmethyl)sulfonamido)propanoyl)pyrrolidine-2- Carboxamido)methyl)phosphonate (mi-492)
311. 6t89: Thrombin in Complex with (s)-n-(tert-butyl)-4-(3-(3- Carbamimidoylphenyl)-2-((2',4'-dimethoxy-[1,1'-biphenyl])-3- Sulfonamido)propanoyl)piperazine-1-carboxamide (mi-498)
312. 6t7h: Crystal Structure of Thrombin in Complex with Macrocycle N14-pr4-a
313. 6t57: Thrombin in Complex with a D-phe-pro-n-amidinopiperidine Derivative
314. 6t56: Thrombin in Complex with Benzylamine
315. 6t55: Thrombin in Complex with Methylbenzylamine
316. 6t54: Thrombin in Complex with a D-phe-pro-2-bromothiophene Derivative
317. 6t53: Thrombin in Complex with a D-phe-pro-p-benzylamine Derivative
318. 6t52: Thrombin in Complex with a D-phe-pro-imidazole Derivative
319. 6t3m: Thrombin in Complex with a D-phe-pro-p-phenol Derivative
320. 6v64: Crystal Structure of Human Thrombin Bound to Ppack with Tryptophans Replaced by 5-f-tryptophan
321. 6v5t: Crystal Structure of Human Prethrombin-2 with Tryptophans Replaced by 5-f-tryptophan
322. 6tdt: Thrombin in Complex with a D-diphe-pro-p-pyridine Derivative
323. 6t4a: Thrombin in Complex with a D-phe-pro-p-aminopyridine Derivative
324. 6t3q: Thrombin in Complex with a D-phe-pro-2-aminopyridine Derivative
325. 3r3g: Structure of Human Thrombin with Residues 145-150 of Murine Thrombin.
326. 3p6z: Structural Basis of Thrombin Mediated Factor V Activation: Essential Role of The Hirudin-like Sequence Glu666-glu672 for Processing at The Heavy Chain-b Domain Junction
327. 3pma: 2.2 Angstrom Crystal Structure of The Complex between Bovine Thrombin and Sucrose Octasulfate
328. 3pmb: 2.9 Angstrom Crystal Structure of Bovine Thrombin in Tetragonal Spacegroup
329. 3pmh: Mechanism of Sulfotyrosine-mediated Glycoprotein Ib Interaction with Two Distinct Alpha-thrombin Sites
330. 3qdz: Crystal Structure of The Human Thrombin Mutant D102N in Complex with The Extracellular Fragment of Human Par4.
331. 3qgn: The Allosteric E*-e Equilibrium Is a Key Property of The Trypsin Fold
332. 3s7h: Structure of Thrombin Mutant Y225P in The E* Form
333. 3s7k: Structure of Thrombin Mutant Y225P in The E Form
334. 3ldx: Discovery and Clinical Evaluation of Rwj-671818, a Thrombin Inhibitor with an Oxyguanidine P1 Motif
335. 6pxq: Crystal Structure of Human Thrombin Mutant D194A
336. 6pxj: Crystal Structure of Human Thrombin Mutant I16T
337. 3p70: Structural Basis of Thrombin-mediated Factor V Activation: Essential Role of The Hirudin-like Sequence Glu666-glu672 for Processing at The Heavy Chain-b Domain Junction
338. 3tu7: Human Alpha-thrombin Complexed with N-(methylsulfonyl)-d-phenylalanyl- N-((1-carbamimidoyl-4-piperidinyl)methyl)-l-prolinamide (bms-189664)
339. 3qlp: X-ray Structure of The Complex between Human Alpha Thrombin and a Modified Thrombin Binding Aptamer (mtba)
340. 3p17: Thrombin Inhibition by Pyridin Derivatives
341. 6rot: Thrombin in Complex with Mi2105
342. 3b23: Crystal Structure of Thrombin-variegin Complex: Insights of a Novel Mechanism of Inhibition and Design of Tunable Thrombin Inhibitors
343. 3po1: Thrombin in Complex with Benzothiazole Guanidine
344. 3sqe: Crystal Structure of Prethrombin-2 Mutant S195A in The Alternative Form
345. 3sqh: Crystal Structure of Prethrombin-2 Mutant S195A in The The Open Form
346. 6px5: Crystal Structure of Human Meizothrombin Desf1 Mutant S195A Bound with Ppack
347. 3qto: Thrombin Inhibition by Pyridin Derivatives
348. 3qtv: Thrombin Inhibition by Pyridin Derivatives
349. 6p9u: Crystal Structure of Human Thrombin Mutant W215A
350. 3qwc: Thrombin Inhibition by Pyridin Derivatives
351. 3qx5: Thrombin Inhibition by Pyridin Derivatives
352. 3u69: Unliganded Wild-type Human Thrombin
353. 3u8t: Human Thrombin Complexed with D-phe-pro-d-arg-cys
354. 3rlw: Human Thrombin in Complex with Mi328
355. 3rly: Human Thrombin in Complex with Mi329
356. 3rm0: Human Thrombin in Complex with Mi354
357. 3rm2: Human Thrombin in Complex with Mi003
358. 3rml: Human Thrombin in Complex with Mi331
359. 3rmm: Human Thrombin in Complex with Mi332
360. 3rmn: Human Thrombin in Complex with Mi341
361. 3rmo: Human Thrombin in Complex with Mi004
362. 4dt7: Crystal Structure of Thrombin Bound to The Activation Domain Qedqvdprlidgkmtrrgds of Protein C
363. 3u8o: Human Thrombin Complexed with D-phe-pro-d-arg-d-thr
364. 3u8r: Human Thrombin Complexed with D-phe-pro-d-arg-ile
365. 3sha: Human Thrombin in Complex with Ubthr97
366. 3shc: Human Thrombin in Complex with Ubthr101
367. 3si3: Human Thrombin in Complex with Ubthr103
368. 3si4: Human Thrombin in Complex with Ubthr104
369. 3sv2: Human Thrombin in Complex with Ubthr105
370. 4ax9: Human Thrombin Complexed with Napsagatran, Ro0466240
371. 4e7r: Thrombin in Complex with 3-amidinophenylalanine Inhibitor
372. 4dih: X-ray Structure of The Complex between Human Alpha Thrombin and Thrombin Binding Aptamer in The Presence of Sodium Ions
373. 4dii: X-ray Structure of The Complex between Human Alpha Thrombin and Thrombin Binding Aptamer in The Presence of Potassium Ions
374. 3t5f: Human Thrombin in Complex with Mi340
375. 4ayv: Human Thrombin - Inhibitor Complex
376. 4ayy: Human Thrombin - Inhibitor Complex
377. 4az2: Human Thrombin - Inhibitor Complex
378. 4dy7: Crystal Structures of Protease Nexin-1 in Complex with S195A Thrombin
379. 3utu: High Affinity Inhibitor of Human Thrombin
380. 3u98: Human Thrombin in Complex with Mi001
381. 3u9a: Human Thrombin in Complex with Mi330
382. 6i51: Thrombin in Complex with Fragment J02
383. 3uwj: Human Thrombin in Complex with Mi353
384. 4e05: Anophelin from The Malaria Vector Inhibits Thrombin through a Novel Reverse-binding Mechanism
385. 4e06: Anophelin from The Malaria Vector Inhibits Thrombin through a Novel Reverse-binding Mechanism
386. 4bah: Thrombin in Complex with Inhibitor
387. 4bak: Thrombin in Complex with Inhibitor
388. 4bam: Thrombin in Complex with Inhibitor
389. 4ban: Thrombin in Complex with Inhibitor
390. 4bao: Thrombin in Complex with Inhibitor
391. 4baq: Thrombin in Complex with Inhibitor
392. 6hsx: Thrombin in Complex with a D-phe-pro-diaminopyridine Derivative
393. 6gwe: Crystal Structure of Thrombin Bound to P2 Macrocycle
394. 4h6s: Crystal Structure of Thrombin Mutant E14EA/D14LA/E18A/S195A
395. 4h6t: Crystal Structure of Prethrombin-2 Mutant E14EA/D14LA/E18A/S195A
396. 4hfp: Structure of Thrombin Mutant S195A Bound to The Active Site Inhibitor Argatroban
397. 6gn7: X-ray Structure of The Complex between Human Alpha Thrombin and Nu172, a Duplex/quadruplex 26-mer Dna Aptamer, in The Presence of Sodium Ions.
398. 6gbw: Thrombin in Complex with Mi2100 ((s)-n-(2-(aminomethyl)-5- Chlorobenzyl)-1-((benzylsulfonyl)-l-arginyl)pyrrolidine-2- Carboxamide)
399. 6fjt: 4-chloro-benzamidine in Complex with Thrombin
400. 4hzh: Structure of Recombinant Gla-domainless Prothrombin Mutant S525A
401. 6evv: X-ray Structure of The Complex between Human Alpha Thrombin and Nu172, a Duplex/quadruplex 26-mer Dna Aptamer, in The Presence of Potassium Ions.
402. 6eo9: Crystal Structure of Thrombin in Complex with a Novel Glucose- Conjugated Potent Inhibitor
403. 6eo8: Crystal Structure of Thrombin in Complex with a Novel Glucose- Conjugated Potent Inhibitor
404. 6eo7: X-ray Structure of The Complex between Human Alpha-thrombin and Modified 15-mer Dna Aptamer Containing 5-(3-(acetamide-n-yl)-1- Propen-1-yl)-2'-deoxyuridine Residue
405. 6eo6: X-ray Structure of The Complex between Human Alpha-thrombin and Modified 15-mer Dna Aptamer Containing 5-(3-(2-(1h-indol-3-yl) Acetamide-n-yl)-1-propen-1-yl)-2'-deoxyuridine Residue
406. 3vxe: Human Alpha-thrombin-bivalirudin Complex at Pd5.0
407. 3vxf: X/n Joint Refinement of Human Alpha-thrombin-bivalirudin Complex Pd5
408. 6cym: Reversible Covalent Direct Thrombin Inhibitors
409. 4boh: Madanins (merops I53) Are Cleaved by Thrombin and Factor Xa
410. 4ch2: Low-salt Crystal Structure of a Thrombin-gpibalpha Peptide Complex
411. 4ch8: High-salt Crystal Structure of a Thrombin-gpibalpha Peptide Complex
412. 4i7y: Crystal Structure of Human Alpha Thrombin in Complex with a 27-mer Aptamer Bound to Exosite II
413. 4loy: Crystal Structure Analysis of Thrombin in Complex with Compound D57, 5-chlorothiophene-2-carboxylic Acid [(s)-2-[2-methyl-3-(2- Oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1- Yl)- 3-oxopropyl]amide (sar107375)
414. 4lxb: Crystal Structure Analysis of Thrombin in Complex with Compound D58
415. 4lz1: X-ray Structure of The Complex between Human Thrombin and The Tba Deletion Mutant Lacking Thymine 12 Nucleobase
416. 4lz4: X-ray Structure of The Complex between Human Thrombin and The Tba Deletion Mutant Lacking Thymine 3 Nucleobase
417. 4mlf: Crystal Structure for The Complex of Thrombin Mutant D102N and Hirudin
418. 4nzq: Crystal Structure of Ca2+-free Prothrombin Deletion Mutant Residues 146-167
419. 4o03: Crystal Structure of Ca2+ Bound Prothrombin Deletion Mutant Residues 146-167
420. 4rn6: Structure of Prethrombin-2 Mutant S195A Bound to The Active Site Inhibitor Argatroban
421. 5to3: Crystal Structure of Thrombin Mutant W215A/E217A Fused to Egf456 of Thrombomodulin via a 31-residue Linker and Bound to Ppack
422. 5nhu: Human Alpha Thrombin Complexed with Anopheles Gambiae Ce5 Anticoagulant
423. 5mm6: Thrombin Mutant A190S in Complex with (s)-1-(d-phenylalanyl)-n-(4- Carbamimidoylbenzyl)pyrrolidine-2-carboxamide
424. 5mls: Thrombin Mutant A190S in Complex with (s)-1-(d-phenylalanyl)-n-(3- Chlorobenzyl)pyrrolidine-2-carboxamide
425. 5mjt: Thrombin Mutant A190S in Complex with (s) -1 - ((r) -2-amino-3,3- Diphenylpropanoyl) -n- (3-chlorobenzyl) Pyrrolidine-2-carboxamide
426. 5lpd: Thrombin in Complex with (s)-1-((r)-2-amino-3-cyclohexylpropanoyl)-n- (2-(aminomethyl)-5-chlorobenzyl) Pyrrolidine-2-carboxamide
427. 5lce: Thrombin in Complex with (s)-1-((r)-2-amino-3-cyclohexylpropanoyl)-n- (5-chloro-2-(hydroxymethyl)benzy L)pyrrolidine-2-carboxamide
428. 5l6n: Disulfated Madanin-thrombin Complex
429. 5jzy: Thrombin in Complex with (s)-1-((r)-2-amino-3-cyclohexylpropanoyl)-n- (4-carbamimidoylbenzyl)pyrrolidine-2-carboxamide
430. 5jfd: Thrombin in Complex with (s)-n-(2-(aminomethyl)-5-chlorobenzyl)-1- ((benzylsulfonyl)-d-arginyl)pyrrolidine-2-carboxamide
431. 5jdu: Crystal Structure for Human Thrombin Mutant D189A
432. 5gim: Crystal Structure of Thrombin-avathrin Complex
433. 5ew2: Human Thrombin Sandwiched between Two Dna Aptamers: Hd22 and Hd1- Deltat12
434. 5ew1: Human Thrombin Sandwiched between Two Dna Aptamers: Hd22 and Hd1- Deltat3
435. 5edm: Crystal Structure of Prothrombin Deletion Mutant Residues 154-167 ( Form I )
436. 5edk: Crystal Structure of Prothrombin Deletion Mutant Residues 146-167 ( Form II ).
437. 5e8e: Crystal Structure of Thrombin Bound to an Exosite 1-specific Iga Fab
438. 5do4: Thrombin-rna Aptamer Complex
439. 5cmx: X-ray Structure of The Complex between Human Alpha Thrombin and a Duplex/quadruplex 31-mer Dna Aptamer
440. 5ahg: Thrombin in Complex with ((4-chlorophenyl)sulfamoyl))diemethylamine
441. 5afz: Thrombin in Complex with (2r)-2-(benzylsulfonylamino)-n-(2-( (4-carbamimidoylphenyl)methylamino)-2-oxo-propyl)-3-phenyl- Propanamide
442. 5afy: Thrombin in Complex with 3-chloro-benzamide
443. 5af9: Thrombin in Complex with 4-methoxy-n-(2-pyridinyl)benzamide
444. 5a2m: Thrombin Inhibitor
445. 4rkj: Crystal Structure of Thrombin Mutant S195T (free Form)
446. 4rko: Crystal Structure of Thrombin Mutant S195T Bound with Ppack
447. 4yes: Thrombin in Complex with (s)-(4-chloro-2-((1-(5-methyl-1h-pyrrole-2- Carbonyl)pyrrolidine-2-carboxamido)methyl)phenyl)methanaminium
448. 4ud9: Thrombin in Complex with 5-chlorothiophene-2-carboxamide
449. 4udw: Thrombin in Complex with 1-(2r)-2-amino-3-phenyl-propanoyl-n-(2, 5dichlorophenyl)methylpyrrolidine-2-carboxamide
450. 4ue7: Thrombin in Complex with 1-amidinopiperidine
451. 4ueh: Thrombin in Complex with Benzamidine
452. 4ufd: Thrombin in Complex with 4-(((1-((2s)-1-((2r)-2-( Benzylsulfonylamino)-3-phenyl-propanoyl)pyrrolidin-2-yl)-1- Oxo-ethyl)amino)methyl)benzamidine
453. 4ufe: Thrombin in Complex with (2r)-2-(benzylsulfonylamino)-n-(2-( (4-carbamimidoylphenyl)methylamino)-2-oxo-butyl)-3-phenyl- Propanamide
454. 4uff: Thrombin in Complex with (2r)-2-(benzylsulfonylamino)-n-(2-( (4-carbamimidoylphenyl)methylamino)-2-oxo-ethyl)-n-methyl- 3-phenyl-propanamide
455. 4ufg: Thrombin in Complex with (2r)-2-(benzylsulfonylamino)-n-(( 1s)-2-((4-carbamimidoylphenyl)methylamino)-1-methyl-2-oxo- Ethyl)-n-methyl-3-phenyl-propanamide Ethane
456. 6z8v: X-ray Structure of The Complex between Human Alpha Thrombin and a Thrombin Binding Aptamer Variant (tba-3l), Which Contains 1-beta-d- Lactopyranosyl Residue in The Side Chain of Thy3 at N3.
457. 6z8w: X-ray Structure of The Complex between Human Alpha Thrombin and a Thrombin Binding Aptamer Variant (tba-3g), Which Contains 1-beta-d- Glucopyranosyl Residue in The Side Chain of Thy3 at N3.
458. 6z8x: X-ray Structure of The Complex between Human Alpha Thrombin and a Thrombin Binding Aptamer Variant (tba-3leu), Which Contains Leucyl Amide in The Side Chain of Thy3 at N3.
459. 6y02: Thrombin in Complex with 13k
460. 6y9h: Thrombin in Complex with D-phe-pro-m-trifluoromethylbenzylamide Derivative (phe2)
461. 6yb6: Thrombin in Complex with D-phe-pro-3-chloro-1,3-dihydroxybenzylamide Derivative (13c)
462. 6yhg: Thrombin in Complex with D-phe-pro-m-methoxybenzylamide Derivative (16a)
463. 6yhj: Thrombin in Complex with D-phe-pro-2-chlorothiophen Derivative (16e)
464. 6ymp: Thrombin in Complex with 3-((5-(tert-butyl)isoxazol-3-yl)methyl) Oxetan-3-amine (j54)
465. 6yn3: Thrombin in Complex with 4-hydroxybenzamide (j89)
466. 6yqv: Thrombin in Complex with 5-chlorothiophene-2-sulfonamide (j94)
467. 7ntu: X-ray Structure of The Complex between Human Alpha Thrombin and Two Duplex/quadruplex Aptamers: Nu172 and Hd22_27mer
468. 6ysj: Thrombin in Complex with 2-amino-1-(4-bromophenyl)ethan-1-one (j10)
469. 6ysx: Thrombin in Complex with 4-amino-n-(5-methylisoxazol-3-yl) Benzenesulfonamide (j80)
470. 6zgo: Thrombin in Complex with D-phe-pro-2-chlorofuran Derivative (13l)
471. 7ac9: Thrombin in Complex with D-arginine (j77)
472. 7mj5: Complex of Human Thrombin with Xc-43