EC 3.4.23.16 - HIV- 1 retropepsin

3D structures of EC 3.4.23.16 - HIV-1 retropepsin in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1a30: Hiv-1 Protease Complexed with a Tripeptide Inhibitor
2. 1a8g: Hiv-1 Protease in Complex with Sdz283-910
3. 1a8k: Crystallographic Analysis of Human Immunodeficiency Virus 1 Protease with an Analog of The Conserved Ca-p2 Substrate: Interactions with Frequently Occurring Glutamic Acid Residue at P2' Position of Substrates
4. 1a94: Structural Basis for Specificity of Retroviral Proteases
5. 1aid: Structure of a Non-peptide Inhibitor Complexed with Hiv-1 Protease: Developing a Cycle of Structure-based Drug Design
6. 1ajv: Hiv-1 Protease in Complex with The Cyclic Sulfamide Inhibitor Aha006
7. 1ajx: Hiv-1 Protease in Complex with The Cyclic Urea Inhibitor Aha001
8. 1axa: Active-site Mobility in Human Immunodeficiency Virus Type 1 Protease as Demonstrated by Crystal Structure of A28S Mutant
9. 1az5: Unliganded Siv Protease Structure in an "open" Conformation
10. 1b11: Structure of Feline Immunodeficiency Virus Protease Complexed with Tl-3-093
11. 1b6j: Hiv-1 Protease Complexed with Macrocyclic Peptidomimetic Inhibitor 1
12. 1b6k: Hiv-1 Protease Complexed with Macrocyclic Peptidomimetic Inhibitor 5
13. 1b6l: Hiv-1 Protease Complexed with Macrocyclic Peptidomimetic Inhibitor 4
14. 1b6m: Hiv-1 Protease Complexed with Macrocyclic Peptidomimetic Inhibitor 6
15. 1b6p: Hiv-1 Protease Complexed with Macrocyclic Peptidomimetic Inhibitor 7
16. 1bdl: Hiv-1 (2:31-37) Protease Complexed with Inhibitor Sb203386
17. 1bdq: Hiv-1 (2:31-37, 47, 82) Protease Complexed with Inhibitor Sb203386
18. 1bdr: Hiv-1 (2: 31, 33-37) Protease Complexed with Inhibitor Sb203386
19. 1bv7: Counteracting Hiv-1 Protease Drug Resistance: Structural Analysis of Mutant Proteases Complexed with Xv638 and Sd146, Cyclic Urea Amides with Broad Specificities
20. 1bv9: Hiv-1 Protease (I84V) Complexed with Xv638 of Dupont Pharmaceuticals
21. 1bve: Hiv-1 Protease-dmp323 Complex in Solution, Nmr, 28 Structures
22. 1bvg: Hiv-1 Protease-dmp323 Complex in Solution, Nmr Minimized Average Structure
23. 1bwa: Hiv-1 Protease (V82F/I84V) Double Mutant Complexed with Xv638 of Dupont Pharmaceuticals
24. 1bwb: Hiv-1 Protease (V82F/I84V) Double Mutant Complexed with Sd146 of Dupont Pharmaceuticals
25. 1d4h: Hiv-1 Protease in Complex with The Inhibitor Bea435
26. 1d4i: Hiv-1 Protease in Complex with The Inhibitor Bea425
27. 1d4j: Hiv-1 Protease in Complex with The Inhibitor Msl370
28. 1d4k: Hiv-1 Protease Complexed with a Macrocyclic Peptidomimetic Inhibitor
29. 1d4l: Hiv-1 Protease Complexed with a Macrocyclic Peptidomimetic Inhibitor
30. 1d4s: Hiv-1 Protease V82F/I84V Double Mutant/tipranavir Complex
31. 1d4y: Hiv-1 Protease Triple Mutant/tipranavir Complex
32. 1daz: Structural and Kinetic Analysis of Drug Resistant Mutants of Hiv-1 Protease
33. 1dmp: Structure of Hiv-1 Protease Complex
34. 1dw6: Structural and Kinetic Analysis of Drug Resistant Mutants of Hiv-1 Protease
35. 1ebk: Structural and Kinetic Analysis of Drug Resistant Mutants of Hiv-1 Protease
36. 1ebw: Hiv-1 Protease in Complex with The Inhibitor Bea322
37. 1eby: Hiv-1 Protease in Complex with The Inhibitor Bea369
38. 1ebz: Hiv-1 Protease in Complex with The Inhibitor Bea388
39. 1ec0: Hiv-1 Protease in Complex with The Inhibitor Bea403
40. 1ec1: Hiv-1 Protease in Complex with The Inhibitor Bea409
41. 1ec2: Hiv-1 Protease in Complex with The Inhibitor Bea428
42. 1ec3: Hiv-1 Protease in Complex with The Inhibitor Msa367
43. 1f7a: How Does a Symmetric Dimer Recognize an Asymmetric Substrate? a Substrate Complex of Hiv-1 Protease.
44. 1fej: Structural Implications of Drug Resistant Mutants of Hiv-1 Protease: High Resolution Crystal Structures of The Mutant Protease/substrate Analog Complexes
45. 1ff0: Structural Implications of Drug Resistant Mutants of Hiv-1 Protease: High Resolution Crystal Structures of The Mutant Protease/substrate Analog Complexes.
46. 1fff: Structural Implications of Drug Resistant Mutants of Hiv-1 Protease : High Resolution Crystal Structures of The Mutant Protease/substrate Analog Complexes.
47. 1ffi: Structural Implications of Drug Resistant Mutants of Hiv-1 Protease: High Resolution Crystal Structures of The Mutant Protease/substrate Analog Complexes
48. 1fg6: Structural Implications of Drug Resistant Mutants of Hiv-1 Protease: High Resolution Crystal Structures of The Mutant Protease/substrate Analog Complexes
49. 1fg8: Structural Implications of Drug Resistant Mutants of Hiv-1 Protease: High Resolution Crystal Structures of The Mutant Protease/substrate Analog Complexes
50. 1fgc: Structural Implications of Drug Resistant Mutants of Hiv-1 Protease: High Resolution Crystal Structures of The Mutant Protease/substrate Analog Complexes
51. 1fiv: Structure of an Inhibitor Complex of Proteinase from Feline Immunodeficiency Virus
52. 1fmb: Eiav Protease Complexed with The Inhibitor Hby-793
53. 1fqx: Crystal Structure of The Complex of Hiv-1 Protease with a Peptidomimetic Inhibitor
54. 1g2k: Hiv-1 Protease with Cyclic Sulfamide Inhibitor, Aha047
55. 1g35: Crystal Structure of Hiv-1 Protease in Complex with Inhibitor, Aha024
56. 1g6l: 1.9a Crystal Structure of Tethered Hiv-1 Protease
57. 1hpo: Hiv-1 Protease Triple Mutant/u103265 Complex
58. 1hvh: Nonpeptide Cyclic Cyanoguanidines as Hiv Protease Inhibitors
59. 1hwr: Molecular Recognition of Cyclic Urea Hiv Protease Inhibitors
60. 1hxb: Hiv-1 Proteinase Complexed with Ro 31-8959
61. 1hxw: Hiv-1 Protease Dimer Complexed with A-84538
62. 1iiq: Crystal Structure of Hiv-1 Protease Complexed with a Hydroxyethylamine Peptidomimetic Inhibitor
63. 1izh: Inhibitor of Hiv Protease with Unusual Binding Mode Potently Inhibiting Multi-resistant Protease Mutants
64. 1izi: Inhibitor of Hiv Protease with Unusual Binding Mode Potently Inhibiting Multi-resistant Protease Mutants
65. 1jld: Potent Hiv Protease Inhibitors Containing a Novel (hydroxyethyl)amide Isostere
66. 1k1t: Combining Mutations in Hiv-1 Protease to Understand Mechanisms of Resistance
67. 1k1u: Combining Mutations in Hiv-1 Protease to Understand Mechanisms of Resistance
68. 1k2b: Combining Mutations in Hiv-1 Protease to Understand Mechanisms of Resistance
69. 1k2c: Combining Mutations in Hiv-1 Protease to Understand Mechanisms of Resistance
70. 1k6c: Lack of Synergy for Inhibitors Targeting a Multi-drug Resistant Hiv-1 Protease
71. 1k6p: Lack of Synergy for Inhibitors Targeting a Multi-drug Resistant Hiv-1 Protease
72. 1k6t: Lack of Synergy for Inhibitors Targeting a Multi-drug Resistant Hiv-1 Protease
73. 1k6v: Lack of Synergy for Inhibitors Targeting a Multi-drug Resistant Hiv-1 Protease
74. 7upj: Hiv-1 Protease/u101935 Complex
75. 6upj: Hiv-2 Protease/u99294 Complex
76. 6fiv: Structural Studies of Hiv and Fiv Proteases Complexed with an Efficient Inhibitor of Fiv Pr
77. 5upj: Hiv-2 Protease/u99283 Complex
78. 5fiv: Structural Studies of Hiv and Fiv Proteases Complexed with an Efficient Inhibitor of Fiv Pr
79. 4upj: Human Immunodeficiency Virus Type 2 Protease Mutant with Lys 57 Replaced by Leu (K57L) Complex with U097410 [4- Hydroxy-3-[1-[3-[[[[(tert-butyloxycarbonyl) Aminomethyl]carbonyl]amino]phenyl]propyl]coumarin
80. 4fiv: Fiv Protease Complexed with an Inhibitor Lp-130
81. 3upj: Human Immunodeficiency Virus Type 2 Protease Mutant with Lys 57 Replaced by Leu (K57L) Complex with U096333 [4- Hydroxy-3-[1-(phenyl)propyl]-7-methoxycoumarin]
82. 3tlh: Structural Studies of Hiv and Fiv Proteases Complexed Withan Efficient Inhibitor of Fiv Pr
83. 1kj4: Substrate Shape Determines Specificity of Recognition Recognition for Hiv-1 Protease: Analysis of Crystal Structures of Six Substrate Complexes
84. 1kj7: Substrate Shape Determines Specificity of Recognition Recognition for Hiv-1 Protease: Analysis of Crystal Structures of Six Substrate Complexes
85. 1kjf: Substrate Shape Determines Specificity of Recognition Recognition for Hiv-1 Protease: Analysis of Crystal Structures of Six Substrate Complexes
86. 1kjg: Substrate Shape Determines Specificity of Recognition Recognition for Hiv-1 Protease: Analysis of Crystal Structures of Six Substrate Complexes
87. 1kjh: Substrate Shape Determines Specificity of Recognition Recognition for Hiv-1 Protease: Analysis of Crystal Structures of Six Substrate Complexes
88. 3oxc: Wild Type Hiv-1 Protease with Antiviral Drug Saquinavir
89. 1kzk: Je-2147-hiv Protease Complex
90. 3ok9: Crystal Structure of Wild-type Hiv-1 Protease with New Oxatricyclic Designed Inhibitor Grl-0519a
91. 3nuo: Crystal Structure of Hiv-1 Protease Mutant L90M with Antiviral Drug Amprenavir
92. 3nuj: Crystal Structure of Hiv-1 Protease Mutant I54V with Antiviral Drug Amprenavir
93. 3nu9: Crystal Structure of Hiv-1 Protease Mutant I84V with Antiviral Drug Amprenavir
94. 3nu6: Crystal Structure of Hiv-1 Protease Mutant I54M with Antiviral Drug Amprenavir
95. 3nu5: Crystal Structure of Hiv-1 Protease Mutant I50V with Antiviral Drug Amprenavir
96. 3nu4: Crystal Structure of Hiv-1 Protease Mutant V32I with Antiviral Drug Amprenavir
97. 3nu3: Wild Type Hiv-1 Protease with Antiviral Drug Amprenavir
98. 1lv1: Crystal Structure Analysis of The Non-active Site Mutant of Tethered Hiv-1 Protease to 2.1a Resolution
99. 1lzq: Crystal Structure of The Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with an Ethylenamine Peptidomimetic Inhibitor BOC-PHE-PSI[CH2CH2NH]-PHE-GLU-PHE-NH2
100. 1m0b: Hiv-1 Protease in Complex with an Ethyleneamine Inhibitor
101. 3n3i: Crystal Structure of G48V/C95F Tethered Hiv-1 Protease/saquinavir Complex
102. 1mer: Hiv-1 Mutant (I84V) Protease Complexed with Dmp450
103. 1mes: Hiv-1 Mutant (I84V) Protease Complexed with Dmp323
104. 1met: Hiv-1 Mutant (V82F) Protease Complexed with Dmp323
105. 1meu: Hiv-1 Mutant (V82F, I84V) Protease Complexed with Dmp323
106. 3mxe: Crystal Structure of Hiv-1 Protease Inhibitor, Kc32 Complexed with Wild-type Protease
107. 3mxd: Crystal Structure of Hiv-1 Protease Inhibitor Kc53 in Complex with Wild-type Protease
108. 1mrw: Structure of Hiv Protease (mutant Q7K L33I L63I) Complexed with Kni-577
109. 1mrx: Structure of Hiv Protease (mutant Q7K L33I L63I V82F I84V ) Complexed with Kni-577
110. 1msm: The Hiv Protease (mutant Q7K L33I L63I) Complexed with Kni- 764 (an Inhibitor)
111. 1msn: The Hiv Protease (mutant Q7K L33I L63I V82F I84V) Complexed with Kni-764 (an Inhibitor)
112. 1mt7: Viability of a Drug-resistant Hiv-1 Protease Mutant: Structural Insights for Better Antiviral Therapy
113. 1mt8: Viability of a Drug-resistant Hiv-1 Protease Mutant: Structural Insights for Better Antiviral Therapy
114. 1mt9: Viability of a Drug-resistant Hiv-1 Protease Mutant: Structural Insights for Better Antiviral Therapy
115. 1mtb: Viability of a Drug-resistant Hiv-1 Protease Mutant: Structural Insights for Better Antiviral Therapy
116. 1mtr: Hiv-1 Protease Complexed with a Cyclic Phe-ile-val Peptidomimetic Inhibitor
117. 1mui: Crystal Structure of Hiv-1 Protease Complexed with Lopinavir.
118. 1n49: Viability of a Drug-resistant Hiv-1 Protease Variant: Structural Insights for Better Anti-viral Therapy
119. 3lzv: Structure of Nelfinavir-resistant Hiv-1 Protease (D30N/N88D) in Complex with Darunavir.
120. 3lzu: Crystal Structure of a Nelfinavir Resistant Hiv-1 Crf01_ae Protease Variant (N88S) in Complex with The Protease Inhibitor Darunavir.
121. 3lzs: Crystal Structure of Hiv-1 Crf01_ae Protease in Complex with Darunavir
122. 1nh0: 1.03 a Structure of Hiv-1 Protease: Inhibitor Binding inside and outside The Active Site
123. 1npa: Crystal Structure of Hiv-1 Protease-hup
124. 1npv: Crystal Structure of Hiv-1 Protease Complexed with Ldc271
125. 1npw: Crystal Structure of Hiv Protease Complexed with Lgz479
126. 3kt2: Crystal Structure of N88D Mutant Hiv-1 Protease
127. 1odw: Native Hiv-1 Proteinase
128. 1odx: Hiv-1 Proteinase Mutant A71T, V82A
129. 1ody: Hiv-1 Protease Complexed with an Inhibitor Lp-130
130. 3kfs: Hiv Protease (pr) Dimer with Inhibitor Tl-3 Bound and Fragment 2f4 in The Outside/top of Flap
131. 3kfr: Hiv Protease (pr) Dimer with Inhibitor Tl-3 Bound and Fragment 1f1 in The Outside/top of Flap
132. 3kfp: Hiv Protease (pr) with Inhibitor Tl-3 Bound, and Dmsos in Exo Site
133. 3kfn: Hiv Protease (pr) with Inhibitor Tl-3 and Fragment Hit 4d9 by Soaking
134. 3kf0: Hiv Protease with Fragment 4d9 Bound
135. 3kdd: Crystal Structure of Hiv-1 Protease (Q7K, L33I, L63I) in Complex with Kni-10265
136. 3kdc: Crystal Structure of Hiv-1 Protease (Q7K, L33I, L63I) in Complex with Kni-10074
137. 3kdb: Crystal Structure of Hiv-1 Protease (Q7K, L33I, L63I) in Complex with Kni-10006
138. 3k4v: New Crystal Form of Hiv-1 Protease/saquinavir Structure Reveals Carbamylation of N-terminal Proline
139. 3jw2: Hiv-1 Protease Mutant G86S with Darunavir
140. 3jvy: Hiv-1 Protease Mutant G86A with Darunavir
141. 3jvw: Hiv-1 Protease Mutant G86A with Symmetric Inhibitor Dmp323
142. 1pro: Hiv-1 Protease Dimer Complexed with A-98881
143. 3i8w: Crystal Structure of a Metallacarborane Inhibitor Bound to Hiv Protease
144. 3i6o: Crystal Structure of Wild Type Hiv-1 Protease with Macrocyclic Inhibitor Grl-0216a
145. 1q94: Structures of Hla-a*1101 in Complex with Immunodominant Nonamer and Decamer Hiv-1 Epitopes Clearly Reveal The Presence of a Middle Anchor Residue
146. 1q9p: Solution Structure of The Mature Hiv-1 Protease Monomer
147. 1qbr: Hiv-1 Protease Inhibitors Wiih Low Nanomolar Potency
148. 1qbs: Hiv-1 Protease Inhibitors Wiih Low Nanomolar Potency
149. 1qbt: Hiv-1 Protease Inhibitors Wiih Low Nanomolar Potency
150. 1qbu: Hiv-1 Protease Inhibitors Wiih Low Nanomolar Potency
151. 3hdk: Crystal Structure of Chemically Synthesized [aib51/51']hiv-1 Protease
152. 3hbo: Crystal Structure of Chemically Synthesized [d-ala51/51']hiv-1 Protease
153. 3h5b: Crystal Structure of Wild Type Hiv-1 Protease with Novel P1'-ligand Grl-02031
154. 1rl8: Crystal Structure of The Complex of Resistant Strain of Hiv- 1 PROTEASE(V82A Mutant) with Ritonavir
155. 1rpi: Crystal Structures of a Multidrug-resistant Hiv-1 Protease Reveal an Expanded Active Site Cavity
156. 1rq9: Crystal Structures of a Multidrug-resistant Hiv-1 Protease Reveal an Expanded Active Site Cavity
157. 3ggu: Hiv Pr Drug Resistant Patient's Variant in Complex with Darunavir
158. 1rv7: Crystal Structures of a Multidrug-resistant Hiv-1 Protease Reveal an Expanded Active Site Cavity
159. 3fx5: Structure of Hiv-1 Protease in Complex with Potent Inhibitor Kni-272 Determined by High Resolution X-ray Crystallography
160. 3fsm: Crystal Structure of a Chemically Synthesized 203 Amino Acid 'covalent Dimer' [l-ala51,d-ala51'] Hiv-1 Protease Molecule
161. 1sdt: Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in Indinavir Binding Site.
162. 1sdu: Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in Indinavir Binding Site.
163. 1sdv: Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in Indinavir Binding Site.
164. 1sgu: Comparing The Accumulation of Active Site and Non-active Site Mutations in The Hiv-1 Protease
165. 1sh9: Comparing The Accumulation of Active Site and Non-active Site Mutations in The Hiv-1 Protease
166. 3fiv: Crystal Structure of Feline Immunodeficiency Virus Protease Complexed with a Substrate
167. 1sp5: Crystal Structure of Hiv-1 Protease Complexed with a Product of Autoproteolysis
168. 1t3r: Hiv Protease Wild-type in Complex with Tmc114 Inhibitor
169. 1t7i: The Structural and Thermodynamic Basis for The Binding of Tmc114, a Next-generation Hiv-1 Protease Inhibitor.
170. 1t7j: Crystal Structure of Inhibitor Amprenavir in Complex with a Multi-drug Resistant Variant of Hiv-1 Protease (L63P/V82T/I84V)
171. 1t7k: Crystal Structure of Hiv Protease Complexed with Arylsulfonamide Azacyclic Urea
172. 3em6: Crystal Structure of I50L/A71V Mutant of Hiv-1 Protease in Complex with Inhibitor Darunavir
173. 3em4: Crystal Structure of Atazanavir (atv) in Complex with I50L/A71V Drug-resistant Hiv-1 Protease
174. 3em3: Crystal Structure of Amprenavir (apv) in Complex with a Drug Resistant Hiv-1 Protease Variant (I50L/A71V).
175. 1tcw: Siv Protease Complexed with Inhibitor Sb203386
176. 1tcx: Hiv Triple Mutant Protease Complexed with Inhibitor Sb203386
177. 3el9: Crystal Structure of Atazanavir (atv) in Complex with a Multidrug Hiv-1 Protease (V82T/I84V)
178. 3el4: Crystal Structure of Inhibitor Saquinavir (sqv) Complexed with The Multidrug Hiv-1 Protease Variant L63P/V82T/I84V
179. 3el1: Crystal Structure of Wild-type Hiv Protease in Complex with The Inhibitor, Atazanavir
180. 3el0: Crystal Structure of The Inhibitor Nelfinavir (nfv) in Complex with a Multi-drug Resistant Hiv-1 Protease Variant (L10I/G48V/I54V/V64I/V82A) (refer: Flap+ in Citation)
181. 3eky: Crystal Structure of Wild-type Hiv Protease in Complex with The Inhibitor, Atazanavir
182. 3ekx: Crystal Structure of The Wild-type Hiv-1 Protease with The Inhibitor, Nelfinavir
183. 3ekw: Crystal Structure of The Inhibitor Atazanavir (atv) in Complex with a Multi-drug Resistance Hiv-1 Protease Variant (L10I/G48V/I54V/V64I/V82A) Refer: Flap+ in Citation.
184. 3ekv: Crystal Structure of The Wild Type Hiv-1 Protease with The Inhibitor, Amprenavir
185. 3ekt: Crystal Structure of The Inhibitor Darunavir (drv) in Complex with a Multi-drug Resistant Hiv-1 Protease Variant (L10F/G48V/I54V/V64I/V82A) (refer: Flap+ in Citation.)
186. 3ekq: Crystal Structure of Inhibitor Saquinavir (sqv) in Complex with Multi-drug Resistant Hiv-1 Protease (L63P/V82T/I84V) (referred to as Act in Paper)
187. 3ekp: Crystal Structure of The Inhibitor Amprenavir (apv) in Complex with a Multi-drug Resistant Hiv-1 Protease Variant (L10I/G48V/I54V/V64I/V82A)REFER: Flap+ in Citation
188. 1tsq: Crystal Structure of AP2V Substrate Variant of Nc-p1 Decamer Peptide in Complex with V82A/D25N Hiv-1 Protease Mutant
189. 1tsu: Crystal Structure of Decamer Ncp1 Substrate Peptide in Complex with Wild-type D25N Hiv-1 Protease Variant
190. 1tw7: Wide Open 1.3a Structure of a Multi-drug Resistant Hiv-1 Protease Represents a Novel Drug Target
191. 3dox: X-ray Structure of Hiv-1 Protease in Situ Product Complex
192. 1u8g: Crystal Structure of a Hiv-1 Protease in Complex with Peptidomimetic Inhibitor Ki2-phe-glu-glu-nh2
193. 3dk1: Wild Type Hiv-1 Protease with Potent Antiviral Inhibitor Grl-0105a
194. 3djk: Wild Type Hiv-1 Protease with Potent Antiviral Inhibitor Grl-0255a
195. 3dcr: X-ray Structure of Hiv-1 Protease and Hydrated Form of Ketomethylene Isostere Inhibitor
196. 3dck: X-ray Structure of D25N Chemical Analogue of Hiv-1 Protease Complexed with Ketomethylene Isostere Inhibitor
197. 3d3t: Crystal Structure of Hiv-1 Crf01_ae in Complex with The Substrate P1-p6
198. 3d20: Crystal Structure of Hiv-1 Mutant I54V and Inhibitor Darunavia
199. 3d1z: Crystal Structure of Hiv-1 Mutant I54M and Inhibitor Darunavir
200. 3d1y: Crystal Structure of Hiv-1 Mutant I54V and Inhibitor Saquina
201. 3d1x: Crystal Structure of Hiv-1 Mutant I54M and Inhibitor Saquinavir
202. 3cyx: Crystal Structure of Hiv-1 Mutant I50V and Inhibitor Saquinavira
203. 3cyw: Effect of Flap Mutations on Structure of Hiv-1 Protease and Inhibition by Saquinavir and Darunavir
204. 3ckt: Hiv-1 Protease in Complex with a Dimethylallyl Decorated Pyrrolidine Based Inhibitor (orthorombic Space Group)
205. 1vij: Hiv-1 Protease Complexed with The Inhibitor Hoe/bay 793 Hexagonal Form
206. 1vik: Hiv-1 Protease Complexed with The Inhibitor Hoe/bay 793 Orthorhombic Form
207. 3bxs: Crystal Structures of Highly Constrained Substrate and Hydrolysis Products Bound to Hiv-1 Protease. Implications for Catalytic Mechanism
208. 3bxr: Crystal Structures of Highly Constrained Substrate and Hydrolysis Products Bound to Hiv-1 Protease. Implications for Catalytic Mechanism
209. 3bvb: Cystal Structure of Hiv-1 Active Site Mutant D25N and Inhibitor Darunavir
210. 3bva: Cystal Structure of Hiv-1 Active Site Mutant D25N and P2-nc Analog Inhibitor
211. 3bhe: Hiv-1 Protease in Complex with a Three Armed Pyrrolidine Derivative
212. 3bgc: Hiv-1 Protease in Complex with a Benzyl Decorated Oligoamine
213. 3bgb: Hiv-1 Protease in Complex with a Isobutyl Decorated Oligoamine
214. 1w5v: Hiv-1 Protease in Complex with Fluoro Substituted Diol- Based C2-symmetric Inhibitor
215. 1w5w: Hiv-1 Protease in Complex with Fluoro Substituted Diol- Based C2-symmetric Inhibitor
216. 1w5x: Hiv-1 Protease in Complex with Fluoro Substituted Diol- Based C2-symmetric Inhibitor
217. 1w5y: Hiv-1 Protease in Complex with Fluoro Substituted Diol- Based C2-symmetric Inhibitor
218. 3bc4: I84V Hiv-1 Protease in Complex with a Pyrrolidine Diester
219. 3b80: Hiv-1 Protease Mutant I54V Complexed with Gem-diol-amine Intermediate Nlltqi
220. 3b7v: Hiv-1 Protease Complexed with Gem-diol-amine Tetrahedral Intermediate Nlltqi
221. 3aid: A New Class of Hiv-1 Protease Inhibitor: The Crystallographic Structure, Inhibition and Chemical Synthesis of an Aminimide Peptide Isostere
222. 3a2o: Crystal Structure of Hiv-1 Protease Complexed with Kni-1689
223. 2zye: Structure of Hiv-1 Protease in Complex with Potent Inhibitor Kni-272 Determined by Neutron Crystallography
224. 2zga: Hiv-1 Protease in Complex with a Dimethylallyl Decorated Pyrrolidine Based Inhibitor (hexagonal Space Group)
225. 2z54: The Influence of I47A Mutation on Reduced Susceptibility to The Protease Inhibitor Lopinavir
226. 2z4o: Wild Type Hiv-1 Protease with Potent Antiviral Inhibitor Grl-98065
227. 1xl2: Hiv-1 Protease in Complex with Pyrrolidinmethanamine
228. 1xl5: Hiv-1 Protease in Complex with Amidhyroxysulfone
229. 2wl0: Hiv-1 Protease Inhibitors Containing a Tertiary Alcohol in The Transition-state Mimic with Improved Cell-based Antiviral Activity
230. 2wkz: Hiv-1 Protease Inhibitors Containing a Tertiary Alcohol in The Transition-state Mimic with Improved Cell-based Antiviral Activity
231. 1ytg: Siv Protease Crystallized with Peptide Product
232. 1yth: Siv Protease Crystallized with Peptide Product
233. 1yti: Siv Protease Crystallized with Peptide Product
234. 1ytj: Siv Protease Crystallized with Peptide Product
235. 2whh: Hiv-1 Protease Tethered Dimer Q-product Complex along with Nucleophilic Water Molecule
236. 1z1h: Hiv-1 Protease Complexed with Macrocyclic Peptidomimetic Inhibitor 3
237. 1z1r: Hiv-1 Protease Complexed with Macrocyclic Peptidomimetic Inhibitor 2
238. 1z8c: Crystal Structure of The Complex of Mutant Hiv-1 Protease (L63P, A71V, V82T, I84V) with a Hydroxyethylamine Peptidomimetic Inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE- Glu-phe-nh2
239. 1zbg: Crystal Structure of a Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with a Hydroxyethylamine Peptidomimetic Inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
240. 1zj7: Crystal Structure of a Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with a Hydroxyethylamine Peptidomimetic Inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
241. 1zlf: Crystal Structure of a Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with a Hydroxyethylamine Peptidomimetic Inhibitor
242. 1zp8: Hiv Protease with Inhibitor Ab-2
243. 1zpa: Hiv Protease with Scripps Ab-3 Inhibitor
244. 1zpk: Crystal Structure of The Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with a Hydroxyethylamine Peptidomimetic Inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
245. 1zsf: Crystal Structure of Complex of a Hydroxyethylamine Inhibitor with Hiv-1 Protease at 2.0a Resolution
246. 1zsr: Crystal Structure of Wild Type Hiv-1 Protease (bru Isolate) with a Hydroxyethylamine Peptidomimetic Inhibitor Boc-phe- PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
247. 1ztz: Crystal Structure of Hiv Protease- Metallacarborane Complex
248. 2a1e: High Resolution Structure of Hiv-1 Pr with Ts-126
249. 2a4f: Synthesis and Activity of N-axyl Azacyclic Urea Hiv-1 Protease Inhibitors with High Potency against Multiple Drug Resistant Viral Strains.
250. 2aid: Structure of a Non-peptide Inhibitor Complexed with Hiv-1 Protease: Developing a Cycle of Structure-based Drug Design
251. 2aoc: Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with a Substrate Analog P2-nc
252. 2aod: Crystal Structure Analysis of Hiv-1 Protease with a Substrate Analog P2-nc
253. 2aoe: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with a Substrate Analog Ca-p2
254. 2aof: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with a Substrate Analog P1-p6
255. 2aog: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with a Substrate Analog P2-nc
256. 2aoh: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with a Substrate Analog P6-pr
257. 2aoi: Crystal Structure Analysis of Hiv-1 Protease with a Substrate Analog P1-p6
258. 2aoj: Crystal Structure Analysis of Hiv-1 Protease with a Substrate Analog P6-pr
259. 2uy0: Two-carbon-elongated Hiv-1 Protease Inhibitors with a Tertiary-alcohol-containing Transition-state Mimic
260. 2uxz: Two-carbon-elongated Hiv-1 Protease Inhibitors with a Tertiary-alcohol-containing Transition-state Mimic
261. 2aqu: Structure of Hiv-1 Protease Bound to Atazanavir
262. 2avm: Kinetics, Stability, and Structural Changes in High Resolution Crystal Structures of Hiv-1 Protease with Drug Resistant Mutations L24I, I50V, and G73S
263. 2avo: Kinetics, Stability, and Structural Changes in High Resolution Crystal Structures of Hiv-1 Protease with Drug Resistant Mutations L24I, I50V, and G73S
264. 2avq: Kinetics, Stability, and Structural Changes in High Resolution Crystal Structures of Hiv-1 Protease with Drug Resistant Mutations L24I, I50V, and G73S
265. 2avs: Kinetics, Stability, and Structural Changes in High Resolution Crystal Structures of Hiv-1 Protease with Drug Resistant Mutations L24I, I50V, and G73S
266. 2avv: Kinetics, Stability, and Structural Changes in High Resolution Crystal Structures of Hiv-1 Protease with Drug Resistant Mutations L24I, I50V, and G73S
267. 2upj: Hiv-1 Protease Complex with U100313 ([3-[[3-[cyclopropyl [4- Hydroxy-2oxo-6-[1-(phenylmethyl)propyl]-2h-pyran-3-yl] Methyl]phenyl]amino]-3-oxo-propyl]carbamic Acid Tert-butyl Ester)
268. 2az8: Hiv-1 Protease Nl4-3 in Complex with Inhibitor, Tl-3
269. 2az9: Hiv-1 Protease Nl4-3 1x Mutant
270. 2azb: Hiv-1 Protease Nl4-3 3x Mutant in Complex with Inhibitor, Tl-3
271. 2azc: Hiv-1 Protease Nl4-3 6x Mutant
272. 2bb9: Structure of Hiv1 Protease and AKC4P_133A Complex.
273. 2bbb: Structure of Hiv1 Protease and Hh1_173_3a Complex.
274. 2rkg: Hiv-1 Pr Resistant Mutant + Lpv
275. 2rkf: Hiv-1 Pr Resistant Mutant + Lpv
276. 2bpv: Hiv-1 Protease-inhibitor Complex
277. 2bpw: Hiv-1 Protease-inhibitor Complex
278. 2bpx: Hiv-1 Protease-inhibitor Complex
279. 2bpy: Hiv-1 Protease-inhibitor Complex
280. 2bpz: Hiv-1 Protease-inhibitor Complex
281. 2bqv: Hiv-1 Protease in Complex with Inhibitor Aha455
282. 2r43: I50V Hiv-1 Protease in Complex with an Amino Decorated Pyrrolidine-based Inhibitor
283. 2r3w: I84V Hiv-1 Protease in Complex with a Amino Decorated Pyrrolidine-based Inhibitor
284. 2r3t: I50V Hiv-1 Protease Mutant in Complex with a Carbamoyl Decorated Pyrrolidine-based Inhibitor
285. 2r38: I84V Hiv-1 Protease Mutant in Complex with a Carbamoyl Decorated Pyrrolidine-based Inhibitor
286. 2qnq: Hiv-1 Protease in Complex with a Chloro Decorated Pyrrolidine-based Inhibitor
287. 2qnp: Hiv-1 Protease in Complex with a Iodo Decorated Pyrrolidine- Based Inhibitor
288. 2qnn: Hiv-1 Protease in Complex with a Multiple Decorated Pyrrolidine-based Inhibitor
289. 2qmp: Crystal Structure of Hiv-1 Protease Complexed with Pl-100
290. 2cej: P1' Extended Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol in The Transition-state Mimicking Scaffold
291. 2cem: P1' Extended Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol in The Transition-state Mimicking Scaffold
292. 2cen: P1' Extended Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol in The Transition-state Mimicking Scaffold
293. 2qhc: The Influence of I47A Mutation on Reduced Susceptibility to The Protease Inhibitor Lopinavir
294. 2qd8: Hiv-1 Protease Mutant I84V with Potent Antiviral Inhibitor Grl-98065
295. 2qd7: Hiv-1 Protease Mutant V82A with Potent Antiviral Inhibitor Grl-98065
296. 2qd6: Hiv-1 Protease Mutant I50V with Potent Antiviral Inhibitor Grl-98065
297. 2qci: Hiv-1 Protease Mutant D30N with Potent Antiviral Inhibitor Grl-98065
298. 2qak: Hiv-1 Pr Mutant in Complex with Nelfinavir
299. 2q64: Hiv-1 Pr Mutant in Complex with Nelfinavir
300. 2q63: Hiv-1 Pr Mutant in Complex with Nelfinavir
301. 2pyn: Hiv-1 Pr Mutant in Complex with Nelfinavir
302. 2pym: Hiv-1 Pr Mutant in Complex with Nelfinavir
303. 2pwr: Hiv-1 Protease in Complex with a Carbamoyl Decorated Pyrrolidine-based Inhibitor
304. 2pwc: Hiv-1 Protease in Complex with a Amino Decorated Pyrrolidine-based Inhibitor
305. 2pqz: Hiv-1 Protease in Complex with a Pyrrolidine-based Inhibitor
306. 2pc0: Apo Wild-type Hiv Protease in The Open Conformation
307. 2p3d: Crystal Structure of The Multi-drug Resistant Mutant Subtype F Hiv Protease Complexed with Tl-3 Inhibitor
308. 2p3c: Crystal Structure of The Subtype F Wild Type Hiv Protease Complexed with Tl-3 Inhibitor
309. 2p3b: Crystal Structure of The Subtype B Wild Type Hiv Protease Complexed with Tl-3 Inhibitor
310. 2p3a: Crystal Structure of The Multi-drug Resistant Mutant Subtype B Hiv Protease Complexed with Tl-3 Inhibitor
311. 6y9z: Structure of The Native Full-length Hiv-1 Capsid Protein in Complex with Cyclophilin a from Helical Assembly (-13,9)
312. 6y9y: Structure of The Native Full-length Hiv-1 Capsid Protein in Complex with Cyclophilin a from Helical Assembly (-7,13)
313. 6y9x: Structure of The Native Full-length Hiv-1 Capsid Protein in Complex with Cyclophilin a from Helical Assembly (-13,7)
314. 6y9w: Structure of The Native Full-length Hiv-1 Capsid Protein in Complex with Cyclophilin a from Helical Assembly (-13,8)
315. 6y9v: Structure of The Native Full-length Hiv-1 Capsid Protein in Complex with Cyclophilin a from Helical Assembly (-8,13)
316. 2o40: Crystal Structure of a Chemically Synthesized 203 Amino Acid 'covalent Dimer' Hiv-1 Protease Molecule
317. 6b3h: Crystal Structure of Hiv Protease Complexed with N-(2-(2-((6r,9s)-2,2- Dioxido-2-thia-1,7-diazabicyclo[4.3.1]decan-9-yl)ethyl)-3- Fluorophenyl)-3,3-bis(4-fluorophenyl)propanamide
318. 6b3g: Crystal Structure of Hiv Protease Complexed with N-(3-fluoro-2-(2- ((2s,6s)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3- Bis(4-fluorophenyl)propanamide
319. 6b3f: Crystal Structure of Hiv Protease Complexed with N-(3-fluoro-2-(2- ((2s,5s)-5-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3- Bis(4-fluorophenyl)propanamide
320. 6b3c: Crystal Structure of Hiv Protease Complexed with N-(3-fluoro-2-(2- ((2s,6r)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3- Bis(4-fluorophenyl)propanamide
321. 6b38: Crystal Structure of Hiv Protease Complexed with N-(3-fluoro-2-(2- ((2s,6r)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3- Bis(4-fluorophenyl)propanamide
322. 6b36: Crystal Structure of Hiv Protease Complexed with (s)-n-(3-fluoro-2-(2- (1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4- Fluorophenyl)propanamide
323. 2nxm: Structure of Hiv-1 Protease D25N Complexed with The Rt-rh Analogue Peptide Gly-ala-gln-thr-phe*tyr-val-asp-gly-ala
324. 2nxl: Structure of Hiv-1 Protease D25N Complexed with The Rt-rh Analogue Peptide Gly-ala-glu-val-phe*tyr-val-asp-gly-ala
325. 2nxd: Structure of Hiv-1 Protease D25N Complexed with Rt-rh Analogue Peptide Gly-ala-asp-ile-phe*tyr-leu-asp-gly-ala
326. 2nph: Crystal Structure of Hiv1 Protease in Situ Product Complex
327. 2nnp: Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with a Inhibitor Saquinavir
328. 2nnk: Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with a Inhibitor Saquinavir
329. 2nmz: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with a Inhibitor Saquinavir
330. 2nmy: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with a Inhibitor Saquinavir
331. 2f3k: Substrate Envelope and Drug Resistance: Crystal Structure of R01 in Complex with Wild-type Hiv-1 Protease
332. 2f80: Hiv-1 Protease Mutant D30N Complexed with Inhibitor Tmc114
333. 2f81: Hiv-1 Protease Mutant L90M Complexed with Inhibitor Tmc114
334. 2f8g: Hiv-1 Protease Mutant I50V Complexed with Inhibitor Tmc114
335. 2fdd: Crystal Structure of Hiv Protease D545701 Bound with Gw0385
336. 2fde: Wild Type Hiv Protease Bound with Gw0385
337. 2fgu: X-ray Crystal Structure of Hiv-1 Protease T80S Variant in Complex with The Inhibitor Saquinavir Used to Explore The Role of Invariant Thr80 in Hiv-1 Protease Structure, Function, and Viral Infectivity.
338. 2fgv: X-ray Crystal Structure of Hiv-1 Protease T80N Variant in Complex with The Inhibitor Saquinavir Used to Explore The Role of Invariant Thr80 in Hiv-1 Protease Structure, Function, and Viral Infectivity.
339. 2fiv: Crystal Structure of Feline Immunodeficiency Virus Protease Complexed with a Substrate
340. 2fns: Crystal Structure of Wild-type Inactive (D25N) Hiv-1 Protease Complexed with Wild-type Hiv-1 Nc-p1 Substrate.
341. 2fnt: Crystal Structure of a Drug-resistant (V82A) Inactive (D25N) Hiv-1 Protease Complexed with AP2V Variant of Hiv-1 Nc-p1 Substrate.
342. 2fxd: X-ray Crystal Structure of Hiv-1 Protease Irm Mutant Complexed with Atazanavir (bms-232632)
343. 2fxe: X-ray Crystal Structure of Hiv-1 Protease Crm Mutant Complexed with Atazanavir (bms-232632)
344. 2g69: Structure of Unliganded Hiv-1 Protease F53L Mutant
345. 5yrs: X-ray Snapshot of Hiv-1 Protease in Action: Observation of Tetrahedral Intermediate and Its Sihb with Catalytic Aspartate
346. 5yoj: Structure of A17 Hiv-1 Protease in Complex with Inhibitor Kni-1657
347. 2hah: The Structure of Fiv 12s Protease in Complex with Tl-3
348. 2hb2: Structure of Hiv Protease 6x Mutant in Apo Form
349. 2hb4: Structure of Hiv Protease Nl4-3 in an Unliganded State
350. 2hc0: Structure of Hiv Protease 6x Mutant in Complex with Ab-2.
351. 2hs1: Ultra-high Resolution X-ray Crystal Structure of Hiv-1 Protease V32I Mutant with Tmc114 (darunavir) Inhibitor
352. 2hs2: Crystal Structure of M46L Mutant of Hiv-1 Protease Complexed with Tmc114 (darunavir)
353. 2i4d: Crystal Structure of Wt Hiv-1 Protease with Gs-8373
354. 2i4u: Hiv-1 Protease with Tmc-126
355. 2i4v: Hiv-1 Protease I84V, L90M with Tmc126
356. 2i4w: Hiv-1 Protease Wt with Gs-8374
357. 2i4x: Hiv-1 Protease I84V, L90M with Gs-8374
358. 2idw: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with a Potent Non-peptide Inhibitor (uic-94017)
359. 2ien: Crystal Structure Analysis of Hiv-1 Protease with a Potent Non-peptide Inhibitor (uic-94017)
360. 2ieo: Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with a Potent Non-peptide Inhibitor (uic-94017)
361. 2jo0: The Solution Structure of The Monomeric Species of The C Terminal Domain of The Ca Protein of Hiv-1
362. 3oy4: Crystal Structure of Hiv-1 L76V Protease in Complex with The Protease Inhibitor Darunavir.
363. 3hau: Crystal Structure of Chemically Synthesized Hiv-1 Protease with Reduced Isostere Mvt-101 Inhibitor
364. 3haw: Crystal Structure of [l-ala51/51']hiv-1 Protease with Reduced Isostere Mvt-101 Inhibitor
365. 3hzc: Crystal Structure of a Chemically Synthesized 203 Amino Acid 'covalent Dimer' [gly51;aib51']hiv-1 Protease Molecule Complexed with Mvt-101 Reduced Isostere Inhibitor
366. 3i2l: Crystal Structure of a Chemically Synthesized [allo-ile50/50']hiv-1 Protease Molecule Complexed with Mvt-101 Reduced Isostere Inhibitor
367. 3iaw: Crystal Structure of a Chemically Synthesized 203 Amino Acid 'covalent Dimer' [gly51;aib51']hiv-1 Protease Molecule Complexed with Mvt-101 Reduced Isostere Inhibitor at 1.6 a Resolution
368. 3ka2: Crystal Structure of Chemically Synthesized 203 Amino Acid 'covalent Dimer' [l-ala;gly51']hiv-1 Protease Molecule Complexed with Mvt-101 Reduced Isostere Inhibitor at 1.4 a Resolution
369. 3mws: Crystal Structure of Group N Hiv-1 Protease
370. 3pwm: Hiv-1 Protease Mutant L76V with Darunavir
371. 3pwr: Hiv-1 Protease Mutant L76V Complexed with Saquinavir
372. 3qin: Crystal Structure of Hiv-1 Rnase H P15 with Engineered E. Coli Loop and Pyrimidinol Carboxylic Acid Inhibitor
373. 3qio: Crystal Structure of Hiv-1 Rnase H with Engineered E. Coli Loop and N- Hydroxy Quinazolinedione Inhibitor
374. 3qip: Structure of Hiv-1 Reverse Transcriptase in Complex with an Rnase H Inhibitor and Nevirapine
375. 6p9b: Hiv-1 Protease Multiple Drug Resistant Mutant PRS5B with Amprenavir
376. 6p9a: Hiv-1 Protease Multiple Mutant PRS5B with Darunavir
377. 3hlo: Crystal Structure of Chemically Synthesized 'covalent Dimer' [gly51/d- Ala51']hiv-1 Protease
378. 3ia9: Crystal Structure of a Chemically Synthesized [D25N]HIV-1 Protease Molecule Complexed with Mvt-101 Reduced Isostere Inhibitor
379. 3ndt: Hiv-1 Protease Saquinavir:ritonavir 1:1 Complex Structure
380. 3ndu: Hiv-1 Protease Saquinavir:ritonavir 1:5 Complex Structure
381. 3ndw: Hiv-1 Protease Saquinavir:ritonavir 1:15 Complex Structure
382. 3ndx: Hiv-1 Protease Saquinavir:ritonavir 1:50 Complex Structure
383. 6ujx: Hiv-1 Wild-type Reverse Transcriptase-dna Complex with (-)-ftc-tp
384. 3gi0: Crystal Structure of a Chemically Synthesized 203 Amino Acid 'covalent Dimer' [l-ala51,d-ala51'] Hiv-1 Protease Molecule Complexed with Jg- 365 Inhibitor
385. 3st5: Crystal Structure of Wild-type Hiv-1 Protease with C3-substituted Hexahydrocyclopentafuranyl Urethane as P2-ligand, Grl-0489a
386. 3nls: Crystal Structure of Hiv-1 Protease in Complex with Kni-10772
387. 3oxv: Crystal Structure of Hiv-1 I50V, A71 Protease in Complex with The Protease Inhibitor Amprenavir.
388. 3oxw: Crystal Structure of Hiv-1 I50V, A71V Protease in Complex with The Protease Inhibitor Darunavir
389. 3oxx: Crystal Structure of Hiv-1 I50V, A71V Protease in Complex with The Protease Inhibitor Atazanavir
390. 3th9: Crystal Structure of Hiv-1 Protease Mutant Q7K V32I L63I with a Cyclic Sulfonamide Inhibitor
391. 3so9: Darunavir in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
392. 3spk: Tipranavir in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
393. 3tam: Crystal Structure of Hiv-1 Reverse Transcriptase (K103N Mutant) in Complex with Inhibitor M06
394. 3nwq: X-ray Structure of Ester Chemical Analogue [o-ile50,o-ile50']hiv-1 Protease Complexed with Mvt-101
395. 3nwx: X-ray Structure of Ester Chemical Analogue [o-ile50,o-ile50']hiv-1 Protease Complexed with Kvs-1 Inhibitor
396. 3nxe: X-ray Structure of Ester Chemical Analogue 'covalent Dimer' [ile50,o- Ile50']hiv-1 Protease Complexed with Mvt-101 Inhibitor
397. 3nxn: X-ray Structure of Ester Chemical Analogue 'covalent Dimer' [ile50,o- Ile50']hiv-1 Protease Complexed with Kvs-1 Inhibitor
398. 3nyg: X-ray Structure of Ester Chemical Analogue [o-gly51,o-gly51']hiv-1 Protease Complexed with Mvt-101 Inhibitor
399. 2xye: Hiv-1 Inhibitors with a Tertiary-alcohol-containing Transition-state Mimic and Various P2 and P1 Prime Substituents
400. 2xyf: Hiv-1 Inhibitors with a Tertiary-alcohol-containing Transition-state Mimic and Various P2 and P1 Prime Substituents
401. 3psu: Hiv-1 Protease in Complex with an Isobutyl Decorated Oligoamine (symmetric Binding Mode)
402. 3qaa: Hiv-1 Wild Type Protease with a Substituted Bis-tetrahydrofuran Inhibitor, Grl-044-10a
403. 3qbf: Hiv-1 Protease (mutant Q7K L33I L63I) in Complex with a Three-armed Pyrrolidine-based Inhibitor
404. 3u7s: Hiv Pr Drug Resistant Patient's Variant in Complex with Darunavir
405. 3qih: Hiv-1 Protease (mutant Q7K L33I L63I) in Complex with a Novel Inhibitor
406. 6prf: Hiv-1 Protease Multiple Drug Resistant Clinical Isolate Mutant Pr20 with Grl-14213a
407. 3qn8: Hiv-1 Protease (mutant Q7K L33I L63I) in Complex with a Novel Inhibitor
408. 3qp0: Hiv-1 Protease (mutant Q7K L33I L63I) in Complex with a Novel Inhibitor
409. 3qpj: Hiv-1 Protease (mutant Q7K L33I L63I) in Complex with a Three-armed Pyrrolidine-based Inhibitor
410. 3qrm: Hiv-1 Protease (mutant Q7K L33I L63I) in Complex with a Three-armed Pyrrolidine-based Inhibitor
411. 3qro: Hiv-1 Protease (mutant Q7K L33I L63I) in Complex with a Three-armed Pyrrolidine-based Inhibitor
412. 3qrs: Hiv-1 Protease (mutant Q7K L33I L63I) in Complex with a Three-armed Pyrrolidine-based Inhibitor
413. 3s43: Hiv-1 Protease Triple Mutants V32I, I47V, V82I with Antiviral Drug Amprenavir
414. 3s53: Hiv-1 Protease Triple Mutants V32I, I47V, V82I with Antiviral Drug Darunavir in Space Group P212121
415. 3s54: Hiv-1 Protease Triple Mutants V32I, I47V, V82I with Antiviral Drug Darunavir in Space Group P21212
416. 3s56: Hiv-1 Protease Triple Mutants V32I, I47V, V82I with Antiviral Drug Saquinavir
417. 6o9e: Structure of Hiv-1 Reverse Transcriptase in Complex with Dna and Indopy-1
418. 4dfg: Crystal Structure of Wild-type Hiv-1 Protease with Cyclopentyltetrahydro- Furanyl Urethanes as P2-ligand, Grl-0249a
419. 3uhl: Crystal Structure of Multidrug Resistant Hiv-1 Protease Clinical Isolate Pr20 in Complex with P2-nc Substrate Analog
420. 3tkg: Crystal Structure of Hiv Model Protease Precursor/saquinavir Complex
421. 3tkw: Crystal Structure of Hiv Protease Model Precursor/darunavir Complex
422. 3tl9: Crystal Structure of Hiv Protease Model Precursor/saquinavir Complex
423. 4a6b: Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based Hiv-1 Protease Inhibitors
424. 4a6c: Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based Hiv-1 Protease Inhibitors
425. 4ep2: Crystal Structure of Inactive Single Chain Wild-type Hiv-1 Protease in Complex with The Substrate Rt-rh
426. 4ep3: Crystal Structure of Inactive Single Chain Wild-type Hiv-1 Protease in Complex with The Substrate Ca-p2
427. 4epj: Crystal Structure of Inactive Single Chain Wild-type Hiv-1 Protease in Complex with The Substrate P2-nc
428. 4eq0: Crystal Structure of Inactive Single Chain Variant of Hiv-1 Protease in Complex with The Substrate P2-nc
429. 4eqj: Crystal Structure of Inactive Single Chain Variant of Hiv-1 Protease in Complex with The Substrate Rt-rh
430. 3t3c: Structure of Hiv Pr Resistant Patient Derived Mutant (comprising 22 Mutations) in Complex with Drv
431. 4fe6: Crystal Structure of Hiv-1 Protease in Complex with an Enamino- Oxindole Inhibitor
432. 3tof: Hiv-1 Protease - Epoxydic Inhibitor Complex (ph 6 - Orthorombic Crystal Form P212121)
433. 3tog: Hiv-1 Protease - Epoxydic Inhibitor Complex (ph 9 - Monoclinic Crystal Form P21)
434. 3toh: Hiv-1 Protease - Epoxydic Inhibitor Complex (ph 9 - Orthorombic Crystal Form P212121)
435. 3t11: Dimeric Inhibitor of Hiv-1 Protease.
436. 3ttp: Structure of Multiresistant Hiv-1 Protease in Complex with Darunavir
437. 4fae: Substrate P2/nc in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
438. 4faf: Substrate Ca/p2 in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
439. 6ixd: X-ray Crystal Structure of Bpi-11 Hiv-1 Protease Complex
440. 4fl8: Hiv-1 Protease Complexed with Gem-diol-amine Tetrahedral Intermediate
441. 4flg: Hiv-1 Protease Mutant I47V Complexed with Reaction Intermediate
442. 4fm6: Hiv-1 Protease Mutant V32I Complexed with Reaction Intermediate
443. 3vf5: Crystal Structure of Hiv-1 Protease Mutant I47V with Novel P1'-ligands Grl-02031
444. 3vf7: Crystal Structure of Hiv-1 Protease Mutant L76V with Novel P1'-ligands Grl-02031
445. 3vfa: Crystal Structure of Hiv-1 Protease Mutant V82A with Novel P1'-ligands Grl-02031
446. 3vfb: Crystal Structure of Hiv-1 Protease Mutant N88D with Novel P1'-ligands Grl-02031
447. 4a4q: Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based Hiv-1 Protease Inhibitors
448. 2fmb: Eiav Protease Complexed with an Inhibitor Lp-130
449. 4b3o: Structures of Hiv-1 Rt and Rna-dna Complex Reveal a Unique Rt Conformation and Substrate Interface
450. 4b3p: Structures of Hiv-1 Rt and Rna-dna Complex Reveal a Unique Rt Conformation and Substrate Interface
451. 4b3q: Structures of Hiv-1 Rt and Rna-dna Complex Reveal a Unique Rt Conformation and Substrate Interface
452. 4i2p: Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with Rilpivirine (tmc278) Based Analogue
453. 4i2q: Crystal Structure of K103N/Y181C Mutant of Hiv-1 Reverse Transcriptase in Complex with Rilpivirine (tmc278) Analogue
454. 6hak: Crystal Structure of Hiv-1 Reverse Transcriptase (rt) in Complex with a Double Stranded Rna Represents The Rt Transcription Initiation Complex Prior to Nucleotide Incorporation
455. 4ej8: Apo Hiv Protease (pr) Dimer in Closed Form with Fragment 1f1 in The Outside/top of Flap
456. 4ejd: Hiv Protease (pr) Dimer in Closed Form with Pepstatin in Active Site and Fragment 1f1 in The Outside/top of Flap
457. 4ejk: Hiv Protease (pr) Dimer in Closed Form with Pepstatin in Active Site and Fragment 1f1-n in The Outside/top of Flap
458. 4ejl: Apo Hiv Protease (pr) Dimer in Closed Form with Fragment 1f1-n in The Outside/top of Flap
459. 4gvm: Hiv-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor
460. 4gw6: Hiv-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor
461. 4id1: Hiv-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor
462. 4f73: Crystal Structure of Active Hiv-1 Protease in Complex with The N Terminal Product of Ca-p2 Cleavage Site
463. 4f74: Crystal Structure of Active Hiv-1 Protease in Complex with The N Terminal Product of The Substrate Ma-ca.
464. 4f75: Crystal Structure of Active Hiv-1 Protease in Complex with The N Terminal Product of The Substrate Rh-in
465. 4f76: Crystal Structure of The Active Hiv-1 Protease in Complex with The Products of P1-p6 Substrate
466. 4j54: Crystal Structure of Multidrug Resistant Hiv-1 Protease Clinical Isolate Pr20 with The Potent Antiviral Inhibitor Grl-0519a
467. 4j55: Crystal Structure of Multidrug Resistant Hiv-1 Protease Clinical Isolate Pr20 with The Potent Antiviral Inhibitor Grl-02031
468. 4j5j: Crystal Structure of Multidrug Resistant Hiv-1 Protease Clinical Isolate Pr20 in Complex with Amprenavir
469. 4hla: Crystal Structure of Wild Type Hiv-1 Protease in Complex with Darunavir
470. 4i8w: Crystal Structure of Wild Type Hiv-1 Protease in Complex with Non- Peptidic Inhibitor, Grl007
471. 4i8z: Crystal Structure of Wild Type Hiv-1 Protease in Complex with Non- Peptidic Inhibitor, Grl008
472. 4jec: Joint Neutron and X-ray Structure of Per-deuterated Hiv-1 Protease in Complex with Clinical Inhibitor Amprenavir
473. 4gb2: Hiv-1 Protease (mutant Q7K L33I L63I) in Complex with a Bicyclic Pyrrolidine Inhibitor
474. 3zps: Design and Synthesis of P1-p3 Macrocyclic Tertiary Alcohol Comprising Hiv-1 Protease Inhibitors
475. 3zpt: Design and Synthesis of P1-p3 Macrocyclic Tertiary Alcohol Comprising Hiv-1 Protease Inhibitors
476. 3zpu: Design and Synthesis of P1-p3 Macrocyclic Tertiary Alcohol Comprising Hiv-1 Protease Inhibitors
477. 6cdl: Hiv-1 Wild Type Protease with Grl-03214a, 6-5-5-ring Fused Umbrella- like Tetrahydropyranofuran as The P2-ligand, a Cyclopropylaminobenzothiazole as The P2'-ligand and 3,5- Difluorophenylmethyl as The P1-ligand
478. 4gye: Mdr 769 Hiv-1 Protease in Complex with Reduced P1F
479. 4gzf: Multi-drug Resistant Hiv-1 Protease 769 Variant with Reduced Lrf Peptide
480. 4hdb: Crystal Structure of Hiv-1 Protease Mutants D30N Complexed with Inhibitor Grl-0519
481. 4hdf: Crystal Structure of Hiv-1 Protease Mutants V82A Complexed with Inhibitor Grl-0519
482. 4hdp: Crystal Structure of Hiv-1 Protease Mutants I50V Complexed with Inhibitor Grl-0519
483. 4he9: Crystal Structure of Hiv-1 Protease Mutants I54M Complexed with Inhibitor Grl-0519
484. 4heg: Crystal Structure of Hiv-1 Protease Mutants R8Q Complexed with Inhibitor Grl-0519
485. 4jmu: Crystal Structure of Hiv Matrix Residues 1-111 in Complex with Inhibitor
486. 4k4p: Tl-3 Inhibited TRP6ALA Hiv Protease
487. 4k4q: Tl-3 Inhibited TRP6ALA Hiv Protease with 3-bromo-2,6-dimethoxybenzoic Acid Bound in Flap Site
488. 4k4r: Tl-3 Inhibited TRP6ALA Hiv Protease with 1-bromo-2-napthoic Acid Bound in Exosite
489. 4kb9: Crystal Structure of Wild-type Hiv-1 Protease with Novel Tricyclic P2- Ligands Grl-0739a
490. 4m8x: Gs-8374, a Novel Phosphonate-containing Inhibitor of Hiv-1 Protease, Effectively Inhibits Hiv Pr Mutants with Amino Acid Insertions
491. 4m8y: Gs-8374, a Novel Phosphonate-containing Inhibitor of Hiv-1 Protease, Effectively Inhibits Hiv Pr Mutants with Amino Acid Insertions
492. 4mc1: Hiv Protease in Complex with SA526P
493. 4mc2: Hiv Protease in Complex with SA525P
494. 4mc6: Hiv Protease in Complex with Sa499
495. 4mc9: Hiv Protease in Complex with Aa74
496. 4qgi: X-ray Crystal Structure of Hiv-1 Protease Variant G48T/L89M in Complex with Saquinavir
497. 4qj2: Crystal Structure of Inactive Hiv-1 Protease Variant (I50V/A71V) in Complex with Wt P1-p6 Substrate
498. 4qj6: Crystal Structure of Inactive Hiv-1 Protease Variant (I50V/A71V) in Complex with P1-p6 Substrate Variant (L449F)
499. 4qj7: Crystal Structure of Inactive Hiv-1 Protease Variant (I50V/A71V) in Complex with P1-p6 Substrate Variant (R452S)
500. 4qj8: Crystal Structure of Inactive Hiv-1 Protease Variant (I50V/A71V) in Complex with P1-p6 Substrate Variant (P453L)
501. 4qj9: Crystal Structure of Inactive Hiv-1 Protease in Complex with P1-p6 Substrate Variant (R452S)
502. 4qja: Crystal Structure of Inactive Hiv-1 Protease in Complex with P1-p6 Substrate Variant (P453L)
503. 4qlh: Crystal Structure of Drug Resistant V82S/V1082S Hiv-1 Protease
504. 5vj3: Hiv Protease (pr) in Open Form with Mg2+ in Active Site and Hive-9 in Eye Site
505. 4u8w: Hiv-1 Wild Type Protease with Grl-050-10a (a Gem-difluoro-bis- Tetrahydrofuran as P2-ligand)
506. 5vea: Hiv Protease (pr) with Tl-3 in Active Site and 4-methylbenzene-1,2- Diamine in Exosite
507. 5vck: Hiv Protease (pr) with Tl-3 in The Active Site and (z)-n-(thiazol-2- Yl)-n'-tosylcarbamimidate in The Exosite
508. 4obd: Crystal Structure of Nelfinavir-resistant, Inactive Hiv-1 Protease (D30N/N88D) in Complex with The P1-p6 Substrate Variant (L449F/S451N)
509. 4obf: Crystal Structure of Nelfinavir-resistant, Inactive Hiv-1 Protease Variant (D30N/N88D) in Complex with The P1-p6 Substrate Variant (S451N)
510. 4obg: Crystal Structure of Nelfinavir-resistant, Inactive Hiv-1 Protease (D30N/N88D) in Complex with The P1-p6 Substrate.
511. 4obh: Crystal Structure of Inactive Hiv-1 Protease in Complex with The P1-p6 Substrate Variant (L449F)
512. 4obj: Crystal Structure of Inactive Hiv-1 Protease in Complex with The P1-p6 Substrate Variant (S451N)
513. 4obk: Crystal Structure of Inactive Hiv-1 Protease in Complex with The P1-p6 Substrate Variant (L449F/S451N)
514. 4we1: Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5-(2- (2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-2- Naphthonitrile (jlj600)
515. 4coe: Macrocyclic Transition-state Mimicking Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol
516. 4cp7: Macrocyclic Transition-state Mimicking Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol
517. 4cpq: Macrocyclic Transition-state Mimicking Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol
518. 4cpr: Macrocyclic Transition-state Mimicking Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol
519. 4cps: Macrocyclic Transition-state Mimicking Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol
520. 4cpt: Macrocyclic Transition-state Mimicking Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol
521. 4cpu: Macrocyclic Transition-state Mimicking Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol
522. 4cpw: Macrocyclic Transition-state Mimicking Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol
523. 4cpx: Macrocyclic Transition-state Mimicking Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol
524. 5tw3: Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5-(2- (2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)-4-fluorophenoxy)- 7-fluoro-2-naphthonitrile (jlj636), a Non-nucleoside Inhibitor
525. 5tuq: Crystal Structure of a 6-cyclohexylmethyl-3-hydroxypyrimidine-2,4- Dione Inhibitor in Complex with Hiv Reverse Transcriptase
526. 5ter: Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5- Chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy) Phenoxy)-8-methyl-2-naphthonitrile (jlj651), a Non-nucleoside Inhibitor
527. 5e5k: Joint X-ray/neutron Structure of Hiv-1 Protease Triple Mutant (V32I, I47V,V82I) with Darunavir at Ph 4.3
528. 5c42: Crystal Structure of Hiv-1 Reverse Transcriptase (K101P) Variant in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl) Ethoxy)phenoxy)indolizine-2-carbonitrile (jlj555), a Non-nucleoside Inhibitor
529. 5c25: Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 6- ((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-5,7-dimethyl-2- Naphthonitrile (jlj639), a Non-nucleoside Inhibitor
530. 5c24: Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 7- ((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-6,8- Dimethylindolizine-2-carbonitrile (jlj605), a Non-nucleoside Inhibitor
531. 5bs4: Hiv-1 Wild Type Protease with Grl-047-11a (a Methylamine Bis- Tetrahydrofuran P2-ligand, 4-amino Sulfonamide Derivative)
532. 5bry: Hiv-1 Wild Type Protease with Grl-011-11a (a Methylamine Bis- Tetrahydrofuran P2-ligand, Sulfonamide Isostere Derivate)
533. 4q1w: Mutations outside The Active Site of Hiv-1 Protease Alter Enzyme Structure and Dynamic Ensemble of The Active Site to Confer Drug Resistance
534. 4q1x: Mutations outside The Active Site of Hiv-1 Protease Alter Enzyme Structure and Dynamic Ensemble of The Active Site to Confer Drug Resistance
535. 4q1y: Mutations outside The Active Site of Hiv-1 Protease Alter Enzyme Structure and Dynamic Ensemble of The Active Site to Confer Drug Resistance
536. 5ah7: Disubstituted Bis-thf Moieties as New P2 Ligands in Non-peptidal Hiv-1 Protease Inhibitors (ii)
537. 4zls: Hiv-1 Wild Type Protease with Grl-096-13a (a Boc-derivative P2-ligand, 3,-5-dimethylbiphenyl P1-ligand)
538. 4zip: Hiv-1 Wild Type Protease with Grl-0648a (a Isophthalamide-derived P2- Ligand)
539. 4q5m: D30N Tethered Hiv-1 Protease Dimer/saquinavir Complex
540. 4yhq: Crystal Structure of Multidrug Resistant Clinical Isolate Pr20 with Grl-5010a
541. 4ye3: Crystal Structure of Multidrug Resistant Hiv-1 Protease Clinical Isolate Pr20 with Inhibitor Grl-4410a
542. 5agz: Disubstituted Bis-thf Moieties as New P2 Ligands in Non- Peptidal Hiv-1 Protease Inhibitors (ii)
543. 5ah6: Disubstituted Bis-thf Moieties as New P2 Ligands in Non- Peptidal Hiv-1 Protease Inhibitors (ii)
544. 5ah8: Disubstituted Bis-thf Moieties as New P2 Ligands in Non-peptidal Hiv-1 Protease Inhibitors (ii)
545. 5ah9: Disubstituted Bis-thf Moieties as New P2 Ligands in Non- Peptidal Hiv-1 Protease Inhibitors (ii)
546. 5aha: Disubstituted Bis-thf Moieties as New P2 Ligands in Non- Peptidal Hiv-1 Protease Inhibitors (ii)
547. 5ahb: Disubstituted Bis-thf Moieties as New P2 Ligands in Non-peptidal Hiv-1 Protease Inhibitors (ii)
548. 5ahc: Disubstituted Bis-thf Moieties as New P2 Ligands in Non- Peptidal Hiv-1 Protease Inhibitors (ii)
549. 7ahx: Hiv-1 Reverse Transcriptase Complex with Dna and D-aspartate Tenofovir with Bound Manganese
550. 7aid: Hiv-1 Reverse Transcriptase Complex with Dna and D-aspartate Tenofovir
551. 7aif: Hiv-1 Reverse Transcriptase Complex with Dna and L-glutamate Tenofovir with Bound Manganese
552. 7aig: Hiv-1 Reverse Transcriptase Complex with Dna and L-glutamate Tenofovir
553. 7aii: Hiv-1 Reverse Transcriptase Complex with Dna and L-methionine Tenofovir with Bound Manganese
554. 7aij: Hiv-1 Reverse Transcriptase Complex with Dna and L-methionine Tenofovir
555. 6vug: Diabody Bound to a Reverse Transcriptase Aptamer Complex
556. 7n6t: Crystal Structure of Inhibitor-free Hiv-1 Prs17 Revertant Mutant Prs17 V48G
557. 7n6v: Crystal Structure of Hiv-1 Protease Multiple Mutants Prs17 with Revertant Mutation V48G Bound to Inhibitor Amprenavir
558. 7n6x: Crystal Structure of Hiv-1 Protease Multiple Mutants Prs17 Bound to Inhibitor Amprenavir
559. 7oxq: Crystal Structure of Hiv-1 Reverse Transcriptase with a Double Stranded Dna in Complex with Fragment 048 at The Transient P-pocket.
560. 7oz2: Crystal Structure of Hiv-1 Reverse Transcriptase with a Double Stranded Dna Showing a Transient P-pocket
561. 7oz5: Crystal Structure of Hiv-1 Reverse Transcriptase with a Double Stranded Dna in Complex with Fragment 166 at The Transient P-pocket.