EC 3.4.23.46 - memapsin 2

3D structures of EC 3.4.23.46 - memapsin 2 in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1fkn: Structure of Beta-secretase Complexed with Inhibitor
2. 3nsh: Bace-1 in Complex with Eln475957
3. 3n4l: Bace-1 in Complex with Eln380842
4. 3msl: Fragment Based Discovery and Optimisation of Bace-1 Inhibitors
5. 3msk: Fragment Based Discovery and Optimisation of Bace-1 Inhibitors
6. 3msj: Structure of Bace (beta Secretase) in Complex with Inhibitor
7. 3lpk: Structure of Bace Bound to Sch747123
8. 3lpj: Structure of Bace Bound to Sch743641
9. 3lpi: Structure of Bace Bound to Sch745132
10. 3lnk: Structure of Bace Bound to Sch743813
11. 3lhg: Bace1 in Complex with The Aminohydantoin Compound 4g
12. 3l5f: Structure of Bace Bound to Sch736201
13. 3l5e: Structure of Bace Bound to Sch736062
14. 3l5d: Structure of Bace Bound to Sch723873
15. 3l5c: Structure of Bace Bound to Sch723871
16. 3l5b: Structure of Bace Bound to Sch713601
17. 3l59: Structure of Bace Bound to Sch710413
18. 3l58: Structure of Bace Bound to Sch589432
19. 3l3a: Bace-1 with The Aminopyridine Compound 32
20. 3l38: Bace1 in Complex with The Aminopyridine Compound 44
21. 3kn0: Structure of Bace Bound to Sch708236
22. 3kmy: Structure of Bace Bound to Sch12472
23. 3kmx: Structure of Bace Bound to Sch346572
24. 3k5g: Human Bace-1 Complex with Bjc060
25. 3k5f: Human Bace-1 Complex with Ayh011
26. 3k5d: Crystal Structure of Bace-1 in Complex with Ahm178
27. 3k5c: Human Bace-1 Complex with Nb-216
28. 3ixk: Potent Beta-secretase 1 Inhibitor
29. 3ixj: Crystal Structure of Beta-secretase 1 in Complex with Selective Beta-secretase 1 Inhibitor
30. 3ivi: Design and Synthesis of Potent Bace-1 Inhibitors with Cellular Activity: Structure-activity Relationship of P1 Substituents
31. 3ivh: Design and Synthesis of Potent Bace-1 Inhibitors with Cellular Activity: Structure-activity Relationship of P1 Substituents
32. 3inh: Bace1 with The Aminohydantoin Compound R-58
33. 3inf: Bace1 with The Aminohydantoin Compound 37
34. 3ine: Bace1 with The Aminohydantoin Compound S-34
35. 3ind: Bace1 with The Aminohydantoin Compound 29
36. 3in4: Bace1 with Compound 38
37. 3in3: Bace1 with Compound 30
38. 3igb: Bace-1 with Compound 3
39. 3i25: Potent Beta-secretase 1 Hydroxyethylene Inhibitor
40. 3hw1: Structure of Bace (beta Secretase) in Complex with Ligand Ev2
41. 3hvg: Structure of Bace (beta Secretase) in Complex with Ev0
42. 3h0b: Discovery of Aminoheterocycles as a Novel Beta-secretase Inhibitor Class
43. 1sgz: Crystal Structure of Unbound Beta-secretase Catalytic Domain.
44. 3fkt: Crystal Structure of Human Beta Secretase Complexed with Spiropiperdine Iminohydantoin Inhibitor
45. 3exo: Crystal Structure of Bace1 Bound to Inhibitor
46. 1tqf: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
47. 3dv5: Crystal Structure of Human Beta-secretase in Complex with Nvp-bav544
48. 3dv1: Crystal Structure of Human Beta-secretase in Complex with Nvp-arv999
49. 3duy: Crystal Structure of Human Beta-secretase in Complex with Nvp-afj144
50. 3dm6: Beta-secretase 1 Complexed with Statine-based Inhibitor
51. 3ckr: Crystal Structure of Bace-1 in Complex with Inhibitor
52. 3ckp: Crystal Structure of Bace-1 in Complex with Inhibitor
53. 3cid: Structure of Bace Bound to Sch726222
54. 3cic: Structure of Bace Bound to Sch709583
55. 3cib: Structure of Bace Bound to Sch727596
56. 3buh: Bace-1 Complexed with Compound 4
57. 3bug: Bace-1 Complexed with Compound 3
58. 3buf: Bace-1 Complexed with Compound 2
59. 3bra: Bace-1 Complexed with Compound 1
60. 1w50: Apo Structure of Bace (beta Secretase)
61. 1w51: Bace (beta Secretase) in Complex with a Nanomolar Non- Peptidic Inhibitor
62. 2zjn: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)- Piperidin-4-yl]-2-(2-methyl-4-sulfamoyl-phenoxy)-acetamide
63. 2zjm: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)- Piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide
64. 2zjl: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with N-[1-(5-bromo-2,3-dimethoxy-benzyl)-piperidin- 4-yl]-4-mercapto-butyramide
65. 2zjk: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic Acid(3-mercapto-propyl)-amide
66. 2zjj: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic Acid (2-mercapto-ethyl)-amide
67. 2zji: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with N-[1-(2,6-dimethoxy-benzyl)-piperidin-4-yl]-4- Mercapto-butyramide
68. 2zjh: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with N-(1-benzyl-piperidin-4-yl)-4-mercapto- Butyramide
69. 2zhv: Crystal Structure of Bace1 at Ph 7.0
70. 2zhu: Crystal Structure of Bace1 at Ph 5.0
71. 2zht: Crystal Structure of Bace1 at Ph 4.5
72. 2zhs: Crystal Structure of Bace1 at Ph 4.0
73. 2zhr: Crystal Structure of Bace1 in Complex with Om99-2 at Ph 5.0
74. 2ze1: X-ray Structure of Bace-1 in Complex with Compound 6g
75. 2zdz: X-ray Structure of Bace-1 in Complex with Compound 3.b.10
76. 1xn2: New Substrate Binding Pockets for Beta-secretase.
77. 1xn3: Crystal Structure of Beta-secretase Bound to a Long Inhibitor with Additional Upstream Residues.
78. 1xs7: Crystal Structure of a Cycloamide-urethane-derived Novel Inhibitor Bound to Human Brain Memapsin 2 (beta-secretase).
79. 2xfk: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(ethylamino)-5-((methylsulfonyl)( Phenyl)amino)benzamide
80. 2xfj: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1- Pyrrolidinyl)benzamide
81. 2xfi: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-((methylsulfonyl)(phenyl)amino) Benzamide
82. 1ym2: Crystal Structure of Human Beta Secretase Complexed with Nvp-aur200
83. 1ym4: Crystal Structure of Human Beta Secretase Complexed with Nvp-amk640
84. 2wjo: Human Bace (beta Secretase) in Complex with Cyclohexanecarboxylic Acid (2-(2-am Ino-6-phenoxy-4h- Quinazolin-3-yl)-2-cyclohexyl-ethyl)-amide
85. 2wf4: Human Bace-1 in Complex with 6-ethyl-1-methyl-n-((1s)-2-oxo- 1-(phenylmethyl)-3-(tetrahydro-2h-pyran-4-ylamino)propyl)- 1,3,4,6-tetrahydro(1,2)thiazepino(5,4,3-cd)indole-8- Carboxamide 2,2-dioxide
86. 2wf3: Human Bace-1 in Complex with 6-(ethylamino)-n-((1s,2r)-2- Hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-( Phenylmethyl)propyl)-1-methyl-1,3,4,5-tetrahydro-2,1- Benzothiazepine-8-carboxamide 2,2-dioxide
87. 2wf2: Human Bace-1 in Complex with 8-ethyl-n-((1s,2r)-2-hydroxy-3- (((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl) Propyl)-1-methyl-3,4,7,8-tetrahydro-1h,6h-(1,2,5) Thiadiazepino(5,4,3-de)quinoxaline-10-carboxamide 2,2- Dioxide
88. 2wf1: Human Bace-1 in Complex with 7-ethyl-n-((1s,2r)-2-hydroxy-3- (((3-(methyloxy)phenyl(methyl)amino)-1-(phenylmethyl) Propyl)-1-methyl-3,4-dihydro-1h-(1,2,5)thiadiazepino(3,4,5- Hi)indole-9-carboxamide 2,2-dioxide
89. 2wf0: Human Bace-1 in Complex with 4-ethyl-n-((1s,2r)-2-hydroxy-1- (phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino) Propyl)-8-(2-oxo-1-pyrrolidinyl)-6-quinolinecarboxamide
90. 2wez: Human Bace-1 in Complex with 1-ethyl-n-((1s,2r)-2-hydroxy-3- (((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl) Propyl)-4-(2-oxo-1-pyrrolidinyl)-1h-indole-6-carboxamide
91. 2vnn: Human Bace-1 in Complex with 7-ethyl-n-((1s,2r)-2-hydroxy-1- (phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino) Propyl)-1-methyl-3,4-dihydro-1h-(1,2,5)thiadiazepino(3,4,5- Hi)indole-9-carboxamide 2,2-dioxide
92. 2vnm: Human Bace-1 in Complex with 3-(1,1-dioxidotetrahydro-2h-1, 2-thiazin-2-yl)-5-(ethylamino)-n-((1s,2r)-2-hydroxy-1-( Phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino) Propyl)benzamide
93. 2vj9: Human Bace-1 in Complex with N-((1s,2r)-3-(cyclohexylamino)- 2-hydroxy-1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo- 1-pyrrolidinyl)benzamide
94. 2vj7: Human Bace-1 in Complex with 3-(ethylamino)-n-((1s,2r)-2- Hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl) Methyl)amino)propyl)-5-(2-oxo-1-pyrrolidinyl)benzamide
95. 2vj6: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1- Pyrrolidinyl)benzamide
96. 2viz: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(2-oxo-1-pyrrolidinyl)-5-(propyloxy) Benzamide
97. 2viy: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(pentylsulfonyl)benzamide
98. 2vij: Human Bace-1 in Complex with 3-(1,1-dioxidotetrahydro-2h-1, 2-thiazin-2-yl)-5-(ethylamino)-n-((1s,2r)-2-hydroxy-1-( Phenylmethyl)-3-(1,2,3,4-tetrahydro-1-naphthalenylamino) Propyl)benzamide
99. 2vie: Human Bace-1 in Complex with N-((1s,2r)-1-benzyl-2-hydroxy- 3-((1,1,5-trimethylhexyl)amino)propyl)-3-(ethylamino)-5-(2- Oxopyrrolidin-1-yl)benzamide
100. 2va7: X-ray Crystal Structure of Beta Secretase Complexed with Compound 27
101. 2va6: X-ray Crystal Structure of Beta Secretase Complexed with Compound 24
102. 2va5: X-ray Crystal Structure of Beta Secretase Complexed with Compound 8c
103. 2b8l: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
104. 2b8v: Crystal Structure of Human Beta-secretase Complexed with L- L000430,469
105. 2qzl: Crystal Structure of Human Beta Secretase Complexed with Ixs
106. 2qzk: Crystal Structure of Human Beta Secretase Complexed with I21
107. 2qu3: Bace1 with Compound 2
108. 2qu2: Bace1 with Compound 1
109. 2qp8: Structure of Bace Bound to Sch734723
110. 2qmg: Structure of Bace Bound to Sch745966
111. 2qmf: Structure of Bace Bound to Sch735310
112. 2qmd: Structure of Bace Bound to Sch722924
113. 2qk5: Structure of Bace1 Bound to Sch626485
114. 2q15: Structure of Bace Complexed to Compound 3a
115. 2q11: Structure of Bace Complexed to Compound 1
116. 2ph8: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
117. 2ph6: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
118. 2p8h: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
119. 2p83: Potent and Selective Isophthalamide S2 Hydroxyethylamine Inhibitor of Bace1
120. 2p4j: Crystal Structure of Beta-secretase Bond to an Inhibitor with Isophthalamide Derivatives at P2-p3
121. 2ohu: X-ray Crystal Structure of Beta Secretase Complexed with Compound 8b
122. 2oht: X-ray Crystal Structure of Beta Secretase Complexed with Compound 7
123. 2ohs: X-ray Crystal Structure of Beta Secretase Complexed with Compound 6b
124. 2ohr: X-ray Crystal Structure of Beta Secretase Complexed with Compound 6a
125. 2ohq: X-ray Crystal Structure of Beta Secretase Complexed with Compound 4
126. 2ohp: X-ray Crystal Structure of Beta Secretase Complexed with Compound 3
127. 2ohn: X-ray Crystal Structure of Beta Secretase Complexed with 4- (4-fluorobenzyl)piperidine
128. 2ohm: X-ray Crystal Structure of Beta Secretase Complexed with N~3~-benzylpyridine-2,3-diamine
129. 2ohl: X-ray Crystal Structure of Beta Secretase Complexed with 2- Aminoquinoline
130. 2ohk: X-ray Crystal Structure of Beta Secretase Complexed with 1- Amino-isoquinoline
131. 2of0: X-ray Crystal Structure of Beta Secretase Complexed with Compound 5
132. 2oah: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
133. 6c2i: Structure of Bace-1 (beta-secretase) in Complex with : N-(3-((1r,5s, 6r)-3-amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4- Fluorophenyl)-5-methoxypyrazine-2-carboxamide
134. 6bfx: Bace Crystal Structure with Hydroxy Pyrrolidine Inhibitor
135. 6bfw: Bace Crystal Structure with Hydroxy Morpholine Inhibitor
136. 6bfe: Bace Crystal Structure with Hydroxy Pyrrolidine Inhibitor
137. 6bfd: Bace Crystal Structure with Hydroxy Pyrrolidine Inhibitor
138. 2ntr: Crystal Structure of Human Bace-1 Bound to Inhibitor
139. 2f3e: Crystal Structure of The Bace Complex with Axq093, a Macrocyclic Inhibitor
140. 2f3f: Crystal Structure of The Bace Complex with Bdf488, a Macrocyclic Inhibitor
141. 2fdp: Crystal Structure of Beta-secretase Complexed with an Amino- Ethylene Inhibitor
142. 2g94: Crystal Structure of Beta-secretase Bound to a Potent and Highly Selective Inhibitor.
143. 2hiz: Crystal Structure of Human Beta-secretase (bace) in The Presence of an Inhibitor
144. 2hm1: Crystal Structure of Human Beta-secretase (bace) in The Presence of an Inhibitor (2)
145. 2iqg: Crystal Structure of Hydroxyethyl Secondary Amine-based Peptidomimetic Inhibitor of Human Beta-secretase (bace)
146. 2irz: Crystal Structure of Human Beta-secretase Complexed with Inhibitor
147. 2is0: Crystal Structure of Human Beta-secretase Complexed with Inhibitor
148. 3kyr: Bace-1 in Complex with a Norstatine Type Inhibitor
149. 6wny: Crystal Structure of Bace1 in Complex with (z)-fluoro-olefin Containing Compound 15
150. 5qdd: Crystal Structure of Bace Complex with Bmc020 Hydrolyzed
151. 5qdc: Crystal Structure of Bace Complex with Bmc019 Hydrolyzed
152. 5qda: Crystal Structure of Bace Complex with Bmc013
153. 5qd9: Crystal Structure of Bace Complex with Bmc005
154. 5qd8: Crystal Structure of Bace Complex with Bmc003
155. 5qd7: Crystal Structure of Bace Complex with Bmc014
156. 5qd6: Crystal Structure of Bace Complex with Bmc004
157. 5qd5: Crystal Structure of Bace Complex with Bmc009
158. 5qd4: Crystal Structure of Bace Complex with Bmc023
159. 5qd3: Crystal Structure of Bace Complex with Bmc010
160. 5qd2: Crystal Structure of Bace Complex with Bmc017
161. 5qd1: Crystal Structure of Bace Complex with Bmc011
162. 5qd0: Crystal Structure of Bace Complex Withbmc006
163. 5qcz: Crystal Structure of Bace Complex with Bmc015
164. 5qcy: Crystal Structure of Bace Complex with Bmc008
165. 5qcx: Crystal Structure of Bace Complex with Bmc007
166. 5qcw: Crystal Structure of Bace Complex with Bmc021
167. 5qcv: Crystal Structure of Bace Complex with Bmc023
168. 5qcu: Crystal Structure of Bace Complex with Bmc022
169. 5qct: Crystal Structure of Bace Complex with Bmc001
170. 5qcs: Crystal Structure of Bace Complex with Bmc024
171. 5qcr: Crystal Structure of Bace Complex with Bmc026
172. 5qcq: Crystal Structure of Bace Complex with Bmc025
173. 5qcp: Crystal Structure of Bace Complex with Bmc018
174. 5qco: Crystal Structure of Bace Complex with Bmc016
175. 3ohf: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with Bms-655295 Aka N~3~-((1s,2r)-1- Benzyl-2-hydroxy-3-((3- Methoxybenzyl)amino)propyl)-n~1~, N~1~-dibutyl-1h-indole-1,3- Dicarboxamide
176. 3ohh: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with Bms-681889 Aka N~1~-butyl-5-cyano- N~3~-((1s,2r)-1-(3,5- Difluorobenzyl)-2-hydroxy-3-((3- Methoxybenzyl)amino)propyl)-n~1~- Methyl-1h-indole-1,3- Dicarboxamide
177. 3pi5: Crystal Structure of Human Beta Secretase in Complex with Bfg356
178. 3qbh: Structure Based Design, Synthesis and Sar of Cyclic Hydroxyethylamine (hea) Bace-1 Inhibitors
179. 3r1g: Structure Basis of Allosteric Inhibition of Bace1 by an Exosite- Binding Antibody
180. 3s2o: Fragment Based Discovery and Optimisation of Bace-1 Inhibitors
181. 6uwv: Bace-1 in Complex with Compound #34
182. 6uwp: Bace-1 in Complex with Compound #32
183. 6uvy: Bace-1 in Complex with Compound #18
184. 6uvv: Bace-1 in Complex with Compound #17
185. 6uvp: Bace-1 in Complex with Compound #3
186. 3ooz: Bace1 in Complex with The Aminohydantoin Compound 102
187. 3r2f: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with Bms-693391 Aka (2s)-2-((3r)-3-acetamido-3-isobutyl-2-oxo-1- Pyrrolidinyl)-n-((1s,2r)-1-(3,5-difluorobenzyl)-2-hydroxy-2-((2r,4r)- 4-propoxy-2-pyrrolidinyl)ethyl)-4-phenylbutanamide
188. 3rsv: Structure of Bace-1 (beta-secretase) in Complex with (r)-3-(2-amino-6- O-tolylquinolin-3-yl)-n-((r)-2,2-dimethyltetrahydro-2h-pyran-4-yl)-2- Methylpropanamide
189. 3rsx: Structure of Bace-1 (beta-secretase) in Complex with 6-(thiophen-3- Yl)quinolin-2-amine
190. 3rth: Structure of Bace-1 (beta-secretase) in Complex with 6-(2-(3,3- Dimethylbut-1-ynyl)phenyl)quinolin-2-amine
191. 3rtm: Structure of Bace-1 (beta-secretase) in Complex with 3-(2- Aminoquinolin-3-yl)-n-cyclohexyl-n-methylpropanamide
192. 3rtn: Structure of Bace-1 (beta-secretase) in Complex with 3-(2-amino-6-o- Tolylquinolin-3-yl)-n-cyclohexylpropanamide
193. 3ru1: Structure of Bace-1 (beta-secretase) in Complex with 3-(2- Aminoquinolin-3-yl)-n-(cyclohexylmethyl)propanamide
194. 3rvi: Structure of Bace-1 (beta-secretase) in Complex with 2-((2-amino-6-o- Tolylquinolin-3-yl)methyl)-n-(cyclohexylmethyl)pentanamide
195. 3s7l: Pyrazolyl and Thienyl Aminohydantoins as Potent Bace1 Inhibitors
196. 3s7m: Pyrazolyl and Thienyl Aminohydantoins as Potent Bace1 Inhibitors
197. 3skf: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with (2s)-2-((3s)-3-(acetylamino)-3-(butan-2-yl)-2-oxopyrrolidin-1- Yl)-n-((2s,3r)-3-hydroxy-4-((3-methoxybenzyl)amino)-1-phenylbutan-2- Yl)-4-phenylbutanamide
198. 3skg: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with (2s)-2-((3r)-3-acetamido-3-isobutyl-2-oxo-1-pyrrolidinyl)-n- ((1s,2r)-1-(3,5-difluorobenzyl)-2-hydroxy-2-(1,2,3,4-tetrahydro-3- Isoquinolinyl)ethyl)-4-phenylbutanamide
199. 3u6a: Rational Design and Synthesis of Aminopiperazinones as Beta Secretase (bace) Inhibitors
200. 3tpj: Apo Structure of Bace1
201. 3tpl: Apo Structure of Bace1
202. 3tpp: Crystal Structure of Bace1 Complexed with an Inhibitor
203. 3tpr: Crystal Structure of Bace1 Complexed with an Inhibitor
204. 3ufl: Discovery of Pyrrolidine-based B-secretase Inhibitors: Lead Advancement through Conformational Design for Maintenance of Ligand Binding Efficiency
205. 6pz4: Co-crystal Structure of Bace with Inhibitor Am-6494
206. 4acu: Aminoimidazoles as Bace-1 Inhibitors. X-ray Crystal Structure of Beta Secretase Complexed with Compound 14
207. 4acx: Aminoimidazoles as Bace-1 Inhibitors. X-ray Crystal Structure of Beta Secretase Complexed with Compound 23
208. 6od6: Structure of Bace-1 in Complex with Ligand 13
209. 4dju: Structure of Bace Bound to 2-imino-3-methyl-5,5-diphenylimidazolidin- 4-one
210. 4djv: Structure of Bace Bound to 2-imino-5-(3'-methoxy-[1,1'-biphenyl]-3- Yl)-3-methyl-5-phenylimidazolidin-4-one
211. 4djw: Structure of Bace Bound to 2-imino-3-methyl-5-phenyl-5-(3-(pyridin-3- Yl)phenyl)imidazolidin-4-one
212. 4djx: Structure of Bace Bound to 5-(3-(5-chloropyridin-3-yl)phenyl)-5- Cyclopropyl-2-imino-3-methylimidazolidin-4-one
213. 4djy: Structure of Bace Bound to (r)-5-cyclopropyl-2-imino-3-methyl-5-(3-(5- (prop-1-yn-1-yl)pyridin-3-yl)phenyl)imidazolidin-4-one
214. 3qi1: Design and Synthesis of Hydroxyethylamine (hea) Bace-1 Inhibitors: Prime Side Chromane-containing Inhibitors
215. 3udh: Crystal Structure of Bace with Compound 1
216. 3udj: Crystal Structure of Bace with Compound 5
217. 3udk: Crystal Structure of Bace with Compound 6
218. 3udm: Crystal Structure of Bace with Compound 8
219. 3udn: Crystal Structure of Bace with Compound 9
220. 3udp: Crystal Structure of Bace with Compound 12
221. 3udq: Crystal Structure of Bace with Compound 13
222. 3udr: Crystal Structure of Bace with Compound 14
223. 3udy: Crystal Structure of Bace with Compound 11
224. 4dh6: Structure of Bace-1 (beta-secretase) in Complex with (2r)-n-((2s,3r)- 1-(benzo[d][1,3]dioxol-5-yl)-3-hydroxy-4-((s)-6'-neopentyl-3',4'- Dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridine]-4'-ylamino) Butan-2-yl)-2-methoxypropanamide
225. 6nw3: Bace1 in Complex with a Macrocyclic Inhibitor
226. 6nv9: Bace1 in Complex with a Macrocyclic Inhibitor
227. 6nv7: Bace1 in Complex with a Macrocyclic Inhibitor
228. 4dpf: Bace-1 in Complex with a Hea-macrocyclic Type Inhibitor
229. 4dpi: Bace-1 in Complex with Hea-macrocyclic Inhibitor, Mv078512
230. 4frs: Structure of Bace in Complex with (s)-4-(3-chloro-5-(5-(prop-1-yn-1- Yl)pyridin-3-yl)thiophen-2-yl)-1,4-dimethyl-6-oxotetrahydropyrimidin- 2(1h)-iminium
231. 6jt3: Crystal Structure of Bace1 in Complex with N-{3-[(4r,5r,6r)-2-amino-5- Fluoro-4,6-dimethyl-5,6-dihydro-4h-1,3-thiazin-4-yl]-4-fluorophenyl}- 5-(fluoromethoxy)pyrazine-2-carboxamide
232. 6jsn: Crystal Structure of Bace1 in Complex with N-{3-[(5r)-3-amino-5- Methyl-9,9-dioxo-2,9lambda6-dithia-4-azaspiro[5.5]undec-3-en-5-yl]-4- Fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide
233. 6jsg: Crystal Structure of Bace1 in Complex with N-{3-[(4s)-2-amino-4- Methyl-5,6-dihydro-4h-1,3-thiazin-4-yl]-4-fluorophenyl}-5- Chloropyridine-2-carboxamide
234. 6jsf: Crystal Structure of Bace1 in Complex with N-(3-((4s,5s)-2-amino-4- Methyl-5-phenyl-5,6-dihydro-4h-1,3-thiazin-4-yl)-4-fluorophenyl)-5- (fluoromethoxy)pyrazine-2-carboxamide
235. 6jse: Crystal Structure of Bace1 in Complex with N-(3-((4s,5r)-2-amino-4- Methyl-5-phenyl-5,6-dihydro-4h-1,3-thiazin-4-yl)-4-fluorophenyl)-5- (fluoromethoxy)pyrazine-2-carboxamide
236. 4fri: Crystal Structure of Bace1 in Complex with Biarylspiro Aminooxazoline 6
237. 4frj: Crystal Structure of Bace1 in Complex with Aminooxazoline Xanthene 9l
238. 4frk: Crystal Structure of Bace1 in Complex with Aminooxazoline Xanthene 11a
239. 4azy: Design and Synthesis of Bace1 Inhibitors with in Vivo Brain Reduction of Beta-amyloid Peptides (compound 10)
240. 4b00: Design and Synthesis of Bace1 Inhibitors with in Vivo Brain Reduction of Beta-amyloid Peptides (compound (r)-41)
241. 4b05: Preclinical Characterization of Azd3839, a Novel Clinical Candidate Bace1 Inhibitor for The Treatment of Alzheimer Disease
242. 4b1c: New Aminoimidazoles as Bace-1 Inhibitors: from Rational Design to Ab-lowering in Brain
243. 4b1d: New Aminoimidazoles as Bace-1 Inhibitors: from Rational Design to Ab-lowering in Brain
244. 4b1e: New Aminoimidazoles as Bace-1 Inhibitors: from Rational Design to Ab-lowering in Brain
245. 4di2: Crystal Structure of Bace1 in Complex with Hydroxyethylamine Inhibitor 37
246. 4dus: Structure of Bace-1 (beta-secretase) in Complex with N-((2s,3r)-1-(4- Fluorophenyl)-3-hydroxy-4-((6'-neopentyl-3',4'- Dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino) Butan-2-yl)acetamide
247. 4fm7: Crystal Structure of Bace with Compound 14g
248. 4fm8: Crystal Structure of Bace with Compound 12a
249. 4fs4: Structure of Bace Bound to (s)-4-(3'-methoxy-[1,1'-biphenyl]-3-yl)-1, 4-dimethyl-6-oxotetrahydropyrimidin-2(1h)-iminium
250. 4fse: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with N-(n-(4-amino-3,5- Dichlorobenzyl)carbamimidoyl)-3-(4- Methoxyphenyl)-5- Methyl-4-isothiazolecarboxamide
251. 4fsl: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-db-mut) Complex with N-(n-(4- Acetamido-3-chloro-5-methylbenzyl) Carbamimidoyl)-3-(4- Methoxyphenyl)-5-methyl-4-isothiazolecarboxamide
252. 4gid: Structure of Beta-secretase Complexed with Inhibitor
253. 4h1e: Structure of Bace-1 Bound to (7ar)-6-benzoyl-7a-(4-(3-cyanophenyl) Thiophen-2-yl)-3-methyl-4-oxohexahydro-1h-pyrrolo[3,4-d]pyrimidin- 2(3h)-iminium
254. 4h3j: Structure of Bace Bound to 2-fluoro-5-(5-(2-imino-3-methyl-4-oxo-6- Phenyloctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-2-yl) Benzonitrile
255. 4ha5: Structure of Bace Bound to (s)-3-(5-(2-imino-1,4-dimethyl-6- Oxohexahydropyrimidin-4-yl)thiophen-3-yl)benzonitrile
256. 3vv6: Crystal Structure of Beta Secetase in Complex with 2-amino-3-methyl-6- ((1s, 2r)-2-phenylcyclopropyl)pyrimidin-4(3h)-one
257. 3vv7: Crystal Structure of Beta Secetase in Complex with 2-amino-6-((1s,2r)- 2-(3'-methoxybiphenyl-3-yl)cyclopropyl)-3-methylpyrimidin-4(3h)-one
258. 3vv8: Crystal Structure of Beta Secetase in Complex with 2-amino-3-methyl-6- ((1s,2r)-2-(3'-methylbiphenyl-4-yl)cyclopropyl)pyrimidin-4(3h)-one
259. 4ewo: Design and Synthesis of Potent Hydroxyethylamine (hea) Bace-1 Inhibitors
260. 4exg: Design and Synthesis of Potent Hydroxyethylamine (hea) Bace-1 Inhibitors
261. 3uqp: Crystal Structure of Bace1 with Its Inhibitor
262. 3uqr: Crystal Structure of Bace1 with Its Inhibitor
263. 3uqu: Crystal Structure of Bace1 with Its Inhibitor
264. 3uqw: Crystal Structure of Bace1 with Its Inhibitor
265. 3uqx: Crystal Structure of Bace1 with Its Inhibitor
266. 3veu: Crystal Structure of Human Beta Secretase in Complex with Nvp-avi326
267. 3vf3: Crystal Structure of Human Beta Secretase in Complex with Nvp-bqq711
268. 3vg1: Crystal Structure of Human Beta Secretase in Complex with Nvp-bur436, Derived from a Soaking Experiment
269. 4d83: Crystal Structure of Human Beta Secretase in Complex with Nvp-bur436, Derived from a Co-crystallization Experiment
270. 4d85: Crystal Structure of Human Beta Secretase in Complex with Nvp-bvi151
271. 4d88: Crystal Structure of Human Beta Secretase in Complex with Nvp-bxq490
272. 4d89: Crystal Structure of Human Beta Secretase in Complex with Nvp-bxd552, Derived from a Soaking Experiment
273. 4d8c: Crystal Structure of Human Beta Secretase in Complex with Nvp-bxd552, Derived from a Co-crystallization Experiment
274. 4h3f: Structure of Bace Bound to 3-(5-((7ar)-2-imino-6-(6-methoxypyridin-2- Yl)-3-methyl-4-oxooctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl) Thiophen-3-yl)benzonitrile
275. 4h3g: Structure of Bace Bound to 2-((7ar)-7a-(4-(3-cyanophenyl)thiophen-2- Yl)-2-imino-3-methyl-4-oxohexahydro-1h-pyrrolo[3,4-d]pyrimidin-6(2h)- Yl)nicotinonitrile
276. 4h3i: Structure of Bace Bound to 3-(5-((7ar)-2-imino-6-(3-methoxypyridin-2- Yl)-3-methyl-4-oxooctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl) Thiophen-3-yl)benzonitrile
277. 4dv9: Crystal Structure of Bace1 with Its Inhibitor
278. 4dvf: Crystal Structure of Bace1 with Its Inhibitor
279. 4fgx: Crystal Structure of Bace1 with Novel Inhibitor
280. 4hzt: Structure-based Design of Novel Dihydroisoquinoline Bace-1 Inhibitors That Do Not Engage The Catalytic Aspartates
281. 4i0e: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel Bace-1 Inhibitors
282. 4i0f: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel Bace-1 Inhibitors
283. 4i0g: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel Bace-1 Inhibitors
284. 4i0h: Spr and Structural Analysis Yield Insight towards Mechanism of Inhibition of Bace Inhibitors.
285. 4i0j: Spr and Structural Analysis Yield Insight towards Mechanism of Inhibition of Bace Inhibitors
286. 4i0z: Structure-based Design of Novel Dihydroisoquinoline Bace-1 Inhibitors That Do Not Engage The Catalytic Aspartates
287. 4i10: Structure-based Design of Novel Dihydroisoquinoline Bace-1 Inhibitors That Do Not Engage The Catalytic Aspartates
288. 4i11: Structure-based Design of Novel Dihydroisoquinoline Bace-1 Inhibitors That Do Not Engage The Catalytic Aspartates.
289. 4i12: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel Bace-1 Inhibitors
290. 4i1c: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel Bace-1 Inhibitors
291. 4joo: Spirocyclic Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
292. 4jp9: Spirocyclic Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
293. 4jpc: Spirocyclic Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
294. 4jpe: Spirocyclic Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
295. 3zmg: Crystal Structure of Bace-1 in Complex with Chemical Ligand
296. 4j0t: Crystal Structure of Bace-1 in Complex with 5-ethoxy-pyridine-2- Carboxylic Acid [3-((r)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4h- [1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
297. 4j0v: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4r,5r)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4h- [1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
298. 4j0y: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4r,5s)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4h- [1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
299. 4j0z: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4s,5r)-2-amino-5-fluoro-4-fluoromethyl-5,6- Dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
300. 4j17: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((s)-2-amino-4-difluoromethyl-5,6-dihydro-4h-[1, 3]oxazin-4-yl)-4-fluoro-phenyl]-amide
301. 4j1c: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((s)-2-amino-5,5-difluoro-4-fluoromethyl-5,6- Dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
302. 4j1e: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4s,6s)-2-amino-4-fluoromethyl-6-trifluoromethyl- 5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
303. 4j1f: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4s,6s)-2-amino-4-methyl-6-trifluoromethyl-5,6- Dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
304. 4j1h: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4s,6r)-2-amino-4-methyl-6-trifluoromethyl-5,6- Dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
305. 4j1i: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4r,5r,6r)-2-amino-5-fluoro-4-methyl-6- Trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]- Amide
306. 4j1k: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4r,5r,6s)-2-amino-5-fluoro-4-methyl-6- Trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]- Amide
307. 3zov: Crystal Structure of Bace-1 in Complex with Chemical Ligand
308. 4fco: Crystal Structure of Bace1 with Its Inhibitor
309. 6fgy: Crystal Structure of Human Bace-1 in Complex with Amino-1,4-oxazine Compound 4
310. 4bek: Crystal Structure of Bace-1 in Complex with Chemical Ligand
311. 4bfd: Crystal Structure of Bace-1 in Complex with Chemical Ligand
312. 4b70: Aminoimidazoles as Bace-1 Inhibitors: from De Novo Design to Ab-lowering in Brain
313. 4b72: Aminoimidazoles as Bace-1 Inhibitors: from De Novo Design to Ab-lowering in Brain
314. 4b77: Aminoimidazoles as Bace-1 Inhibitors: from De Novo Design to Ab-lowering in Brain
315. 4b78: Aminoimidazoles as Bace-1 Inhibitors: from De Novo Design to Ab-lowering in Brain
316. 4k8s: Hydroxyethylamine-based Inhibitors of Bace1: P1-p3 Macrocyclization Can Improve Potency, Selectivity, and Cell Activity
317. 4k9h: Bace-1 Inhibitor Complex
318. 4ke0: Crystal Structure of Bace1 in Complex with Hydroxyethylamine- Macrocyclic Inhibitor 13
319. 4ke1: Crystal Structure of Bace1 in Complex with Hydroxyethylamine- Macrocyclic Inhibitor 19
320. 4b0q: Lead Generation of Bace1 Inhibitors by Coupling Non-amidine New Warheads to a Known Binding Scaffold
321. 6eqm: Crystal Structure of Human Bace-1 in Complex with Cnp520
322. 6ej3: Bace1 Compound 23
323. 6ej2: Bace1 Compound 28
324. 6jt4: Crystal Structure of Bace1 in Complex with N-{3-[(4s,6s)-2-amino-4- Methyl-6-(trifluoromethyl)-5,6-dihydro-4h-1,3-thiazin-4-yl]-4- Fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide
325. 6e3z: Structure of Bace-1 in Complex with Ligand 8
326. 6dmi: A Multiconformer Ligand Model of 5t5 Bound to Bace-1
327. 6dhc: X-ray Structure of Bace1 in Complex with a Bicyclic Isoxazoline Carboxamide as The P3 Ligand
328. 3wb4: Crystal Structure of Beta Secetase in Complex with 2-amino-3,6- Dimethyl-6-(2-phenylethyl)-3,4,5,6-tetrahydropyrimidin-4-one
329. 3wb5: Crystal Structure of Beta Secetase in Complex with (6s)-2-amino-3,6- Dimethyl-6-[(1r,2r)-2-phenylcyclopropyl]-3,4,5,6-tetrahydropyrimidin- 4-one
330. 4gmi: Bace-1 in Complex with Hea-type Macrocyclic Inhibitor, Mv078571
331. 4i0d: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel Bace-1 Inhibitors
332. 4i0i: Spr and Structural Analysis Yield Insight towards Mechanism of Inhibition of Bace Inhibitors
333. 4ivs: Crystal Structure of Bace1 with Its Inhibitor
334. 4ivt: Crystal Structure of Bace1 with Its Inhibitor
335. 4j0p: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((s)-2-amino-4-methyl-5,6-dihydro-4h-[1,3]oxazin- 4-yl)-4-fluoro-phenyl]-amide
336. 4l7g: Diethylaminosulfur Trifluoride-mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity against Beta-secretase-1 (bace1)
337. 4l7h: Diethylaminosulfur Trifluoride-mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity against Beta-secretase-1 (bace-1)
338. 4l7j: Diethylaminosulfur Trifluoride-mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity against Beta-secretase-1 (bace-1)
339. 4lc7: Aminooxazoline Inhibitor of Bace-1
340. 4lxa: Crystal Structure of Human Beta Secretase in Complex with Compound 11a
341. 4lxk: Crystal Structure of Human Beta Secretase in Complex with Compound 11d
342. 4lxm: Crystal Structure of Human Beta Secretase in Complex with Compound 12a
343. 4n00: Discovery of 7-thp Chromans: Bace1 Inhibitors That Reduce A-beta in The Cns
344. 5ygy: Crystal Structure of Bace1 in Complex with (s)-n-(3-(2-amino-6- (fluoromethyl)-4 -methyl-4h-1,3-oxazin-4-yl)-4-fluorophenyl)-5- Cyanopicolinamide
345. 5ygx: Structure of Bace1 in Complex with N-(3-((4r,5r,6s)-2-amino-6-(1,1- Difluoroethyl)-5-fluoro-4-methyl-5,6-dihydro-4h-1,3-oxazin-4-yl)-4- Fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide
346. 4pzw: Synthesis, Characterization and Pk/pd Studies of a Series of Spirocyclic Pyranochromene Bace1 Inhibitors
347. 4pzx: Synthesis, Characterization and Pk/pd Studies of a Series of Spirocyclic Pyranochromene Bace1 Inhibitors
348. 4r8y: Bace-1 in Complex with (r)-4-(2-cyclohexylethyl)-4-(((r)-1-(2- Cyclopentylacetyl)pyrrolidin-3-yl)methyl)-1-methyl-5-oxoimidazolidin- 2-iminium
349. 4r91: Bace-1 in Complex with (r)-4-(2-cyclohexylethyl)-4-(((1s,3r)-3- (cyclopentylamino)cyclohexyl)methyl)-1-methyl-5-oxoimidazolidin-2- Iminium
350. 4r92: Bace-1 in Complex with (r)-4-(2-cyclohexylethyl)-4-(((1s,3r)-3- (isonicotinamido)cyclohexyl)methyl)-1-methyl-5-oxoimidazolidin-2- Iminium
351. 4r93: Bace-1 in Complex with (r)-4-(2-cyclohexylethyl)-1-methyl-5-oxo-4- (((1s,3r)-3-(3-phenylureido)cyclohexyl)methyl)imidazolidin-2-iminium
352. 4r95: Bace-1 in Complex with 2-(((1r,3s)-3-(((r)-4-(2-cyclohexylethyl)-2- Iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino) Quinolin-1-ium
353. 5v0n: Bace1 in Complex with Inhibitor 5g
354. 5uyu: Crystal Structure of Bace1 in Complex with 2-aminooxazoline-3- Azaxanthene Compound 12
355. 4r5n: 8-tetrahydropyran-2-yl Chromans: Highly Selective Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
356. 4rrn: 8-tetrahydropyran-2-yl Chromans: Highly Selective Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
357. 4rro: 8-tetrahydropyran-2-yl Chromans: Highly Selective Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
358. 4rrs: 8-tetrahydropyran-2-yl Chromans: Highly Selective Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
359. 5tol: Crystal Structure of Beta-site App-cleaving Enzyme 1 Complexed with N- (3-((4as,7as)-2-amino-4,4a,5,6-tetrahydro-7ah-furo[2,3-d][1, 3]thiazin-7a-yl)-4-fluorophenyl)-5-bromo-2-pyridinecarboxamide
360. 5t1w: Aminomethyl-derived Beta Secretase (bace1) Inhibitors: Engaging Gly230 without an Anilide Functionality
361. 5t1u: Aminomethyl-derived Beta Secretase (bace1) Inhibitors: Engaging Gly230 without an Anilide Functionality
362. 5mxd: Bace-1 in Complex with Ligand 32397778
363. 5mcq: Crystal Structure of Bace-1 in Complex with Active Site and Exosite Binding Peptide Inhibitor
364. 5mco: Crystal Structure of Bace-1 in Complex with Active Site Inhibitor Grl- 8234 and Exosite Peptide
365. 5mbw: Crystal Structure of Bace-1 in Complex with Pep
366. 5kr8: (4~{s},6~{s})-4-[2,4-bis(fluoranyl)phenyl]-6-(3,5-dimethyl-1,2-oxazol- 4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine (compound 5) Bound to Bace1
367. 5kqf: (4~{s},6~{s})-4-[2,4-bis(fluoranyl)phenyl]-4-methyl-6-pyrimidin-5-yl- 5,6-dihydro-1,3-thiazin-2-amine (compound 12) Bound to Bace1
368. 5ie1: Crystal Structure of Bace1 in Complex with 3-(2-amino-6-(o-tolyl) Quinolin-3-yl)-n-(3,3-dimethylbutyl)propanamide
369. 5i3y: Crystal Structure of Bace1 in Complex with Aminoquinoline Inhibitor 9
370. 5i3x: Crystal Structure of Bace1 in Complex with Aminoquinoline Inhibitor 6
371. 5i3w: Crystal Structure of Bace1 in Complex with 2-aminooxazoline-3- Azaxanthene Inhibitor 2
372. 5i3v: Crystal Structure of Bace1 in Complex with Aminoquinoline Compound 1
373. 5hu1: Bace1 in Complex with (r)-n-(3-(3-amino-2,5-dimethyl-1,1-dioxido-5,6- Dihydro-2h-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5- Fluoropicolinamide
374. 5hu0: Bace1 in Complex with 4-(3-(furan-2-carboxamido)phenyl)-1-methyl-5- Oxo-4-phenylimidazolidin-2-iminium
375. 5htz: Bace1 in Complex with (s)-5-(3-chloro-5-(5-(prop-1-yn-1-yl)pyridin-3- Yl)thiophen-2-yl)-2,5-dimethyl-1,2,4-thiadiazinan-3-iminium 1,1- Dioxide
376. 5he7: Bace-1 in Complex with (4ar,7as)-7a-(2,4-difluorophenyl)-6-(5-fluoro- 4-methoxy-6-methylpyrimidin-2-yl)-2-imino-3-methyloctahydro-4h- Pyrrolo[3,4-d]pyrimidin-4-one
377. 5he5: Bace-1 in Complex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4- Methyl-6-(methylamino)pyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h- Pyrrolo[3,4-d]pyrimidin-2-iminium
378. 5he4: Bace-1 in Complex with (4ar,7as)-7a-(2,6-difluorophenyl)-6-(5-fluoro- 4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h- Pyrrolo[3,4-d]pyrimidin-2-iminium
379. 5hdz: Bace-1 in Complex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4- Methyl-6-(methylthio)pyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h- Pyrrolo[3,4-d]pyrimidin-2-iminium
380. 5hdx: Bace-1 in Complex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(4-ethoxy-5- Fluoro-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3, 4-d]pyrimidin-2-iminium
381. 5hdv: Bace-1 Incomplex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4- Methoxy-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3, 4-d]pyrimidin-2-iminium
382. 5hdu: Bace-1 Incomplex with (7ar)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-6-(5- Fluoro-4-methoxypyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3, 4-d]pyrimidin-2-iminium
383. 5hd0: Bace-1 in Complex with (7ar)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-6-(5- Fluoropyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4- D]pyrimidin-2-iminium
384. 5f01: Crystal Structure of Bace-1 in Complex with (1sr,2sr)-2-((r)-2-amino- 5,5-difluoro-4-methyl-5,6-dihydro-4h-1,3-oxazin-4-yl)-n-(3- Chloroquinolin-8-yl)cyclopropanecarboxamide
385. 5f00: Crystal Structure of Bace-1 in Complex with 5-[3-[(3-chloro-8- Quinolyl)amino]phenyl]-5-methyl-2,6-dihydro-1,4-oxazin-3-amine
386. 5ezz: Crystal Structure of Bace-1 in Complex with (4s)-4-[3-(5-chloro-3- Pyridyl)phenyl]-4-[4-(difluoromethoxy)-3-methyl-phenyl]-5h-oxazol-2- Amine
387. 5ezx: Crystal Structure of Bace-1 in Complex with {(1r,2r)-2-[(r)-2-amino-4- (4-difluoromethoxy-phenyl)-4,5-dihydro-oxazol-4-yl]-cyclopropyl}-(5- Chloro-pyridin-3-yl)-methanone
388. 5enm: Compound 10
389. 5enk: Compound 18
390. 5dqc: Co-crystal of Bace1 with Compound 0211
391. 5clm: 1,4-oxazine Bace1 Inhibitors
392. 4rce: Crystal Structure of Bace1 in Complex with Aminooxazoline Xanthene Inhibitor 2
393. 4rcf: Crystal Structure of Bace1 in Complex with 2-aminooxazoline 4- Fluoroxanthene Inhibitor 49
394. 4x7i: Crystal Structure of Bace with Amino Thiazine Inhibitor Ly2886721
395. 4rcd: Crystal Structure of Bace1 in Complex with a 2-aminooxazoline 4- Azaxanthene Inhibitor
396. 4xkx: Crystal Structure of Bace1 in Complex with 2-aminooxazoline 3- Azaxanthene Inhibitor 28
397. 4zsr: Bace Crystal Structure with Tricyclic Aminothiazine Inhibitor
398. 4zsq: Bace Crystal Structure with Tricyclic Aminothiazine Inhibitor
399. 4zsp: Bace Crystal Structure with Bicyclic Aminothiazine Inhibitor
400. 4zsm: Bace Crystal Structure with Bicyclic Aminothiazine Fragment
401. 4zpg: Bace1 in Complex with 8-benzyl-4-(cyclohexylamino)-1-(3-fluorophenyl)- 7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one
402. 4zpf: Bace1 in Complex with 8-(3-((1-aminopropan-2-yl)oxy)benzyl)-4- (cyclohexylamino)-1-(3-fluorophenyl)-1,3,8-triazaspiro[4.5]dec-3-en- 2-one
403. 4zpe: Bace1 in Complex with 4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3- Isopropoxybenzyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one
404. 4wtu: Crystal Structure of Bace1 in Complex with 2-aminooxazoline 3-aza-4- Fluoro-xanthene Inhibitor 22
405. 4wy1: Crystal Structure of Human Bace-1 Bound to Compound 24b
406. 4wy6: Crystal Structure of Human Bace-1 Bound to Compound 36
407. 4x2l: Crystal Structure of Human Bace-1 Bound to Compound 6
408. 4xxs: Crystal Structure of Bace1 with a Pyrazole-substituted Tetrahydropyran Thioamidine
409. 4ybi: Crystal Structure of Bace with Amino Thiazine Inhibitor Ly2811376
410. 4trw: Structure of Bace1 Complex with a Syn-hea-type Inhibitor
411. 4try: Structure of Bace1 Complex with a Hea-type Inhibitor
412. 4trz: Structure of Bace1 Complex with 2-thiophenyl Hea-type Inhibitor
413. 7dcz: Crystal Structure of Bace1 in Complex with N-{3-[(4s)-2-amino-4- Methyl-4h-1,3-thiazin-4-yl]-4- Fluorophenyl}-5-cyanopyridine-2- Carboxamide
414. 7d2v: Crystal Structure of Bace1 in Complex with N-{3-[(5r)-3-amino-2,5- Dimethyl-1,1-dioxo-5,6-dihydro-2h-1lambda6,2,4-thiadiazin-5-yl]-4- Fluorophenyl}-5-fluoropyridine-2-carboxamide
415. 7d2x: Crystal Structure of Bace1 in Complex with N-{3-[(4r)-2-amino-4-(prop- 1-yn-1-yl)-5,6-dihydro-4h-1,3-oxazin-4-yl]-4-fluorophenyl}-5- Cyanopyridine-2-carboxamide
416. 7d5a: Crystal Structure of Bace1 in Complex with N-{3-[(9s)-7-amino-2,2- Difluoro-9-(prop-1-yn-1-yl)-6-oxa-8-azaspiro[3.5]non-7-en-9-yl]-4- Fluorophenyl}-5-cyanopyridine-2-carboxamide
417. 7b1e: Bace1 in Complex with Compound 3 (nb-641)
418. 7b1p: Crystal Structure of Human Bace-1 in Complex with Compound 38a (nb- 854)
419. 7b1q: Crystal Structure of Human Bace-1 in Complex with Compound Nb-360 (compound 54)
420. 7myr: Bace-1 in Complex with Compound #18
421. 7myi: Bace-1 in Complex with Compound #6
422. 7myu: Bace-1 in Complex with Compound #22
423. 7d36: Crystal Structure of Bace1 in Complex with N-{3-[(3s)-1-amino-5- Fluoro-3-methyl-3,4-dihydro-2,6-naphthyridin-3-yl]-4-fluorophenyl}-5- Cyano-3-methylpyridine-2-carboxamide
424. 7n66: Bace-1 in Complex with Ligand 12