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enzyme (lysozyme)

 
Enzymes
  Enzyme classes:
  EC 1: Oxidoreductases
  EC 2: Transferases
  EC 3: Hydrolases
    EC 3.1
    EC 3.2
    EC 3.3
    EC 3.4
      EC 3.4.1
      EC 3.4.2
      EC 3.4.3
      EC 3.4.4
      EC 3.4.11
      EC 3.4.12
      EC 3.4.13
      EC 3.4.14
      EC 3.4.15
      EC 3.4.16
      EC 3.4.17
      EC 3.4.18
      EC 3.4.19
      EC 3.4.21
      EC 3.4.22
      EC 3.4.23
        EC 3.4.23.1
        EC 3.4.23.2
        EC 3.4.23.3
        EC 3.4.23.4
        EC 3.4.23.5
        EC 3.4.23.6
        EC 3.4.23.7
        EC 3.4.23.8
        EC 3.4.23.9
        EC 3.4.23.10
        EC 3.4.23.11
        EC 3.4.23.12
        EC 3.4.23.13
        EC 3.4.23.14
        EC 3.4.23.15
        EC 3.4.23.16
        EC 3.4.23.17
        EC 3.4.23.18
        EC 3.4.23.19
        EC 3.4.23.20
        EC 3.4.23.21
        EC 3.4.23.22
        EC 3.4.23.23
        EC 3.4.23.24
        EC 3.4.23.25
        EC 3.4.23.26
        EC 3.4.23.27
        EC 3.4.23.28
        EC 3.4.23.29
        EC 3.4.23.30
        EC 3.4.23.31
        EC 3.4.23.32
        EC 3.4.23.33
        EC 3.4.23.34
        EC 3.4.23.35
        EC 3.4.23.36
        EC 3.4.23.37
        EC 3.4.23.38
        EC 3.4.23.39
        EC 3.4.23.40
        EC 3.4.23.41
        EC 3.4.23.42
        EC 3.4.23.43
        EC 3.4.23.44
        EC 3.4.23.45
        EC 3.4.23.46
        EC 3.4.23.47
        EC 3.4.23.48
        EC 3.4.23.49
      EC 3.4.24
      EC 3.4.25
      EC 3.4.99
    EC 3.5
    EC 3.6
    EC 3.7
    EC 3.8
    EC 3.9
    EC 3.10
    EC 3.11
    EC 3.12
    EC 3.13
  EC 4: Lyases
  EC 5: Isomerases
  EC 6: Ligases
  General information:
  Catalytic mechanism
  Enzyme kinetics
  Inhibitors
  Enzymes in industry

EC 3.4.23.46 - memapsin 2



3D structures of EC 3.4.23.46 - memapsin 2 in Protein Data Bank

updated: 26 February 2021, 5:15

In total: 412 PDB structures of EC 3.4.23.46 - memapsin 2:
  1. 1fkn: Structure of Beta-secretase Complexed with Inhibitor
  2. 3nsh: Bace-1 in Complex with Eln475957
  3. 3n4l: Bace-1 in Complex with Eln380842
  4. 3msl: Fragment Based Discovery and Optimisation of Bace-1 Inhibitors
  5. 3msk: Fragment Based Discovery and Optimisation of Bace-1 Inhibitors
  6. 3msj: Structure of Bace (beta Secretase) in Complex with Inhibitor
  7. 3lpk: Structure of Bace Bound to Sch747123
  8. 3lpj: Structure of Bace Bound to Sch743641
  9. 3lpi: Structure of Bace Bound to Sch745132
  10. 3lnk: Structure of Bace Bound to Sch743813
  11. 3lhg: Bace1 in Complex with The Aminohydantoin Compound 4g
  12. 3l5f: Structure of Bace Bound to Sch736201
  13. 3l5e: Structure of Bace Bound to Sch736062
  14. 3l5d: Structure of Bace Bound to Sch723873
  15. 3l5c: Structure of Bace Bound to Sch723871
  16. 3l5b: Structure of Bace Bound to Sch713601
  17. 3l59: Structure of Bace Bound to Sch710413
  18. 3l58: Structure of Bace Bound to Sch589432
  19. 3l3a: Bace-1 with The Aminopyridine Compound 32
  20. 3l38: Bace1 in Complex with The Aminopyridine Compound 44
  21. 3kn0: Structure of Bace Bound to Sch708236
  22. 3kmy: Structure of Bace Bound to Sch12472
  23. 3kmx: Structure of Bace Bound to Sch346572
  24. 3k5g: Human Bace-1 Complex with Bjc060
  25. 3k5f: Human Bace-1 Complex with Ayh011
  26. 3k5d: Crystal Structure of Bace-1 in Complex with Ahm178
  27. 3k5c: Human Bace-1 Complex with Nb-216
  28. 3ixk: Potent Beta-secretase 1 Inhibitor
  29. 3ixj: Crystal Structure of Beta-secretase 1 in Complex with Selective Beta-secretase 1 Inhibitor
  30. 3ivi: Design and Synthesis of Potent Bace-1 Inhibitors with Cellular Activity: Structure-activity Relationship of P1 Substituents
  31. 3ivh: Design and Synthesis of Potent Bace-1 Inhibitors with Cellular Activity: Structure-activity Relationship of P1 Substituents
  32. 3inh: Bace1 with The Aminohydantoin Compound R-58
  33. 3inf: Bace1 with The Aminohydantoin Compound 37
  34. 3ine: Bace1 with The Aminohydantoin Compound S-34
  35. 3ind: Bace1 with The Aminohydantoin Compound 29
  36. 3in4: Bace1 with Compound 38
  37. 3in3: Bace1 with Compound 30
  38. 3igb: Bace-1 with Compound 3
  39. 3i25: Potent Beta-secretase 1 Hydroxyethylene Inhibitor
  40. 3hw1: Structure of Bace (beta Secretase) in Complex with Ligand Ev2
  41. 3hvg: Structure of Bace (beta Secretase) in Complex with Ev0
  42. 3h0b: Discovery of Aminoheterocycles as a Novel Beta-secretase Inhibitor Class
  43. 1sgz: Crystal Structure of Unbound Beta-secretase Catalytic Domain.
  44. 3fkt: Crystal Structure of Human Beta Secretase Complexed with Spiropiperdine Iminohydantoin Inhibitor
  45. 3exo: Crystal Structure of Bace1 Bound to Inhibitor
  46. 1tqf: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
  47. 3dv5: Crystal Structure of Human Beta-secretase in Complex with Nvp-bav544
  48. 3dv1: Crystal Structure of Human Beta-secretase in Complex with Nvp-arv999
  49. 3duy: Crystal Structure of Human Beta-secretase in Complex with Nvp-afj144
  50. 3dm6: Beta-secretase 1 Complexed with Statine-based Inhibitor
  51. 3ckr: Crystal Structure of Bace-1 in Complex with Inhibitor
  52. 3ckp: Crystal Structure of Bace-1 in Complex with Inhibitor
  53. 3cid: Structure of Bace Bound to Sch726222
  54. 3cic: Structure of Bace Bound to Sch709583
  55. 3cib: Structure of Bace Bound to Sch727596
  56. 3buh: Bace-1 Complexed with Compound 4
  57. 3bug: Bace-1 Complexed with Compound 3
  58. 3buf: Bace-1 Complexed with Compound 2
  59. 3bra: Bace-1 Complexed with Compound 1
  60. 1w50: Apo Structure of Bace (beta Secretase)
  61. 1w51: Bace (beta Secretase) in Complex with a Nanomolar Non- Peptidic Inhibitor
  62. 2zjn: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)- Piperidin-4-yl]-2-(2-methyl-4-sulfamoyl-phenoxy)-acetamide
  63. 2zjm: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)- Piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide
  64. 2zjl: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with N-[1-(5-bromo-2,3-dimethoxy-benzyl)-piperidin- 4-yl]-4-mercapto-butyramide
  65. 2zjk: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic Acid(3-mercapto-propyl)-amide
  66. 2zjj: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic Acid (2-mercapto-ethyl)-amide
  67. 2zji: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with N-[1-(2,6-dimethoxy-benzyl)-piperidin-4-yl]-4- Mercapto-butyramide
  68. 2zjh: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with N-(1-benzyl-piperidin-4-yl)-4-mercapto- Butyramide
  69. 2zhv: Crystal Structure of Bace1 at Ph 7.0
  70. 2zhu: Crystal Structure of Bace1 at Ph 5.0
  71. 2zht: Crystal Structure of Bace1 at Ph 4.5
  72. 2zhs: Crystal Structure of Bace1 at Ph 4.0
  73. 2zhr: Crystal Structure of Bace1 in Complex with Om99-2 at Ph 5.0
  74. 2ze1: X-ray Structure of Bace-1 in Complex with Compound 6g
  75. 2zdz: X-ray Structure of Bace-1 in Complex with Compound 3.b.10
  76. 1xn2: New Substrate Binding Pockets for Beta-secretase.
  77. 1xn3: Crystal Structure of Beta-secretase Bound to a Long Inhibitor with Additional Upstream Residues.
  78. 1xs7: Crystal Structure of a Cycloamide-urethane-derived Novel Inhibitor Bound to Human Brain Memapsin 2 (beta-secretase).
  79. 2xfk: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(ethylamino)-5-((methylsulfonyl)( Phenyl)amino)benzamide
  80. 2xfj: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1- Pyrrolidinyl)benzamide
  81. 2xfi: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-((methylsulfonyl)(phenyl)amino) Benzamide
  82. 1ym2: Crystal Structure of Human Beta Secretase Complexed with Nvp-aur200
  83. 1ym4: Crystal Structure of Human Beta Secretase Complexed with Nvp-amk640
  84. 2wjo: Human Bace (beta Secretase) in Complex with Cyclohexanecarboxylic Acid (2-(2-am Ino-6-phenoxy-4h- Quinazolin-3-yl)-2-cyclohexyl-ethyl)-amide
  85. 2wf4: Human Bace-1 in Complex with 6-ethyl-1-methyl-n-((1s)-2-oxo- 1-(phenylmethyl)-3-(tetrahydro-2h-pyran-4-ylamino)propyl)- 1,3,4,6-tetrahydro(1,2)thiazepino(5,4,3-cd)indole-8- Carboxamide 2,2-dioxide
  86. 2wf3: Human Bace-1 in Complex with 6-(ethylamino)-n-((1s,2r)-2- Hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-( Phenylmethyl)propyl)-1-methyl-1,3,4,5-tetrahydro-2,1- Benzothiazepine-8-carboxamide 2,2-dioxide
  87. 2wf2: Human Bace-1 in Complex with 8-ethyl-n-((1s,2r)-2-hydroxy-3- (((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl) Propyl)-1-methyl-3,4,7,8-tetrahydro-1h,6h-(1,2,5) Thiadiazepino(5,4,3-de)quinoxaline-10-carboxamide 2,2- Dioxide
  88. 2wf1: Human Bace-1 in Complex with 7-ethyl-n-((1s,2r)-2-hydroxy-3- (((3-(methyloxy)phenyl(methyl)amino)-1-(phenylmethyl) Propyl)-1-methyl-3,4-dihydro-1h-(1,2,5)thiadiazepino(3,4,5- Hi)indole-9-carboxamide 2,2-dioxide
  89. 2wf0: Human Bace-1 in Complex with 4-ethyl-n-((1s,2r)-2-hydroxy-1- (phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino) Propyl)-8-(2-oxo-1-pyrrolidinyl)-6-quinolinecarboxamide
  90. 2wez: Human Bace-1 in Complex with 1-ethyl-n-((1s,2r)-2-hydroxy-3- (((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl) Propyl)-4-(2-oxo-1-pyrrolidinyl)-1h-indole-6-carboxamide
  91. 2vnn: Human Bace-1 in Complex with 7-ethyl-n-((1s,2r)-2-hydroxy-1- (phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino) Propyl)-1-methyl-3,4-dihydro-1h-(1,2,5)thiadiazepino(3,4,5- Hi)indole-9-carboxamide 2,2-dioxide
  92. 2vnm: Human Bace-1 in Complex with 3-(1,1-dioxidotetrahydro-2h-1, 2-thiazin-2-yl)-5-(ethylamino)-n-((1s,2r)-2-hydroxy-1-( Phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino) Propyl)benzamide
  93. 2vj9: Human Bace-1 in Complex with N-((1s,2r)-3-(cyclohexylamino)- 2-hydroxy-1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo- 1-pyrrolidinyl)benzamide
  94. 2vj7: Human Bace-1 in Complex with 3-(ethylamino)-n-((1s,2r)-2- Hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl) Methyl)amino)propyl)-5-(2-oxo-1-pyrrolidinyl)benzamide
  95. 2vj6: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1- Pyrrolidinyl)benzamide
  96. 2viz: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(2-oxo-1-pyrrolidinyl)-5-(propyloxy) Benzamide
  97. 2viy: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(pentylsulfonyl)benzamide
  98. 2vij: Human Bace-1 in Complex with 3-(1,1-dioxidotetrahydro-2h-1, 2-thiazin-2-yl)-5-(ethylamino)-n-((1s,2r)-2-hydroxy-1-( Phenylmethyl)-3-(1,2,3,4-tetrahydro-1-naphthalenylamino) Propyl)benzamide
  99. 2vie: Human Bace-1 in Complex with N-((1s,2r)-1-benzyl-2-hydroxy- 3-((1,1,5-trimethylhexyl)amino)propyl)-3-(ethylamino)-5-(2- Oxopyrrolidin-1-yl)benzamide
  100. 2va7: X-ray Crystal Structure of Beta Secretase Complexed with Compound 27
  101. 2va6: X-ray Crystal Structure of Beta Secretase Complexed with Compound 24
  102. 2va5: X-ray Crystal Structure of Beta Secretase Complexed with Compound 8c
  103. 2b8l: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
  104. 2b8v: Crystal Structure of Human Beta-secretase Complexed with L- L000430,469
  105. 2qzl: Crystal Structure of Human Beta Secretase Complexed with Ixs
  106. 2qzk: Crystal Structure of Human Beta Secretase Complexed with I21
  107. 2qu3: Bace1 with Compound 2
  108. 2qu2: Bace1 with Compound 1
  109. 2qp8: Structure of Bace Bound to Sch734723
  110. 2qmg: Structure of Bace Bound to Sch745966
  111. 2qmf: Structure of Bace Bound to Sch735310
  112. 2qmd: Structure of Bace Bound to Sch722924
  113. 2qk5: Structure of Bace1 Bound to Sch626485
  114. 2q15: Structure of Bace Complexed to Compound 3a
  115. 2q11: Structure of Bace Complexed to Compound 1
  116. 2ph8: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
  117. 2ph6: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
  118. 2p8h: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
  119. 2p83: Potent and Selective Isophthalamide S2 Hydroxyethylamine Inhibitor of Bace1
  120. 2p4j: Crystal Structure of Beta-secretase Bond to an Inhibitor with Isophthalamide Derivatives at P2-p3
  121. 2ohu: X-ray Crystal Structure of Beta Secretase Complexed with Compound 8b
  122. 2oht: X-ray Crystal Structure of Beta Secretase Complexed with Compound 7
  123. 2ohs: X-ray Crystal Structure of Beta Secretase Complexed with Compound 6b
  124. 2ohr: X-ray Crystal Structure of Beta Secretase Complexed with Compound 6a
  125. 2ohq: X-ray Crystal Structure of Beta Secretase Complexed with Compound 4
  126. 2ohp: X-ray Crystal Structure of Beta Secretase Complexed with Compound 3
  127. 2ohn: X-ray Crystal Structure of Beta Secretase Complexed with 4- (4-fluorobenzyl)piperidine
  128. 2ohm: X-ray Crystal Structure of Beta Secretase Complexed with N~3~-benzylpyridine-2,3-diamine
  129. 2ohl: X-ray Crystal Structure of Beta Secretase Complexed with 2- Aminoquinoline
  130. 2ohk: X-ray Crystal Structure of Beta Secretase Complexed with 1- Amino-isoquinoline
  131. 2of0: X-ray Crystal Structure of Beta Secretase Complexed with Compound 5
  132. 2oah: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
  133. 6c2i: Structure of Bace-1 (beta-secretase) in Complex with : N-(3-((1r,5s, 6r)-3-amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4- Fluorophenyl)-5-methoxypyrazine-2-carboxamide
  134. 6bfx: Bace Crystal Structure with Hydroxy Pyrrolidine Inhibitor
  135. 6bfw: Bace Crystal Structure with Hydroxy Morpholine Inhibitor
  136. 6bfe: Bace Crystal Structure with Hydroxy Pyrrolidine Inhibitor
  137. 6bfd: Bace Crystal Structure with Hydroxy Pyrrolidine Inhibitor
  138. 2ntr: Crystal Structure of Human Bace-1 Bound to Inhibitor
  139. 2f3e: Crystal Structure of The Bace Complex with Axq093, a Macrocyclic Inhibitor
  140. 2f3f: Crystal Structure of The Bace Complex with Bdf488, a Macrocyclic Inhibitor
  141. 2fdp: Crystal Structure of Beta-secretase Complexed with an Amino- Ethylene Inhibitor
  142. 2g94: Crystal Structure of Beta-secretase Bound to a Potent and Highly Selective Inhibitor.
  143. 2hiz: Crystal Structure of Human Beta-secretase (bace) in The Presence of an Inhibitor
  144. 2hm1: Crystal Structure of Human Beta-secretase (bace) in The Presence of an Inhibitor (2)
  145. 2iqg: Crystal Structure of Hydroxyethyl Secondary Amine-based Peptidomimetic Inhibitor of Human Beta-secretase (bace)
  146. 2irz: Crystal Structure of Human Beta-secretase Complexed with Inhibitor
  147. 2is0: Crystal Structure of Human Beta-secretase Complexed with Inhibitor
  148. 3kyr: Bace-1 in Complex with a Norstatine Type Inhibitor
  149. 6wny: Crystal Structure of Bace1 in Complex with (z)-fluoro-olefin Containing Compound 15
  150. 5qdd: Crystal Structure of Bace Complex with Bmc020 Hydrolyzed
  151. 5qdc: Crystal Structure of Bace Complex with Bmc019 Hydrolyzed
  152. 5qda: Crystal Structure of Bace Complex with Bmc013
  153. 5qd9: Crystal Structure of Bace Complex with Bmc005
  154. 5qd8: Crystal Structure of Bace Complex with Bmc003
  155. 5qd7: Crystal Structure of Bace Complex with Bmc014
  156. 5qd6: Crystal Structure of Bace Complex with Bmc004
  157. 5qd5: Crystal Structure of Bace Complex with Bmc009
  158. 5qd4: Crystal Structure of Bace Complex with Bmc023
  159. 5qd3: Crystal Structure of Bace Complex with Bmc010
  160. 5qd2: Crystal Structure of Bace Complex with Bmc017
  161. 5qd1: Crystal Structure of Bace Complex with Bmc011
  162. 5qd0: Crystal Structure of Bace Complex Withbmc006
  163. 5qcz: Crystal Structure of Bace Complex with Bmc015
  164. 5qcy: Crystal Structure of Bace Complex with Bmc008
  165. 5qcx: Crystal Structure of Bace Complex with Bmc007
  166. 5qcw: Crystal Structure of Bace Complex with Bmc021
  167. 5qcv: Crystal Structure of Bace Complex with Bmc023
  168. 5qcu: Crystal Structure of Bace Complex with Bmc022
  169. 5qct: Crystal Structure of Bace Complex with Bmc001
  170. 5qcs: Crystal Structure of Bace Complex with Bmc024
  171. 5qcr: Crystal Structure of Bace Complex with Bmc026
  172. 5qcq: Crystal Structure of Bace Complex with Bmc025
  173. 5qcp: Crystal Structure of Bace Complex with Bmc018
  174. 5qco: Crystal Structure of Bace Complex with Bmc016
  175. 3ohf: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with Bms-655295 Aka N~3~-((1s,2r)-1- Benzyl-2-hydroxy-3-((3- Methoxybenzyl)amino)propyl)-n~1~, N~1~-dibutyl-1h-indole-1,3- Dicarboxamide
  176. 3ohh: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with Bms-681889 Aka N~1~-butyl-5-cyano- N~3~-((1s,2r)-1-(3,5- Difluorobenzyl)-2-hydroxy-3-((3- Methoxybenzyl)amino)propyl)-n~1~- Methyl-1h-indole-1,3- Dicarboxamide
  177. 3pi5: Crystal Structure of Human Beta Secretase in Complex with Bfg356
  178. 3qbh: Structure Based Design, Synthesis and Sar of Cyclic Hydroxyethylamine (hea) Bace-1 Inhibitors
  179. 3r1g: Structure Basis of Allosteric Inhibition of Bace1 by an Exosite- Binding Antibody
  180. 3s2o: Fragment Based Discovery and Optimisation of Bace-1 Inhibitors
  181. 6uwv: Bace-1 in Complex with Compound #34
  182. 6uwp: Bace-1 in Complex with Compound #32
  183. 6uvy: Bace-1 in Complex with Compound #18
  184. 6uvv: Bace-1 in Complex with Compound #17
  185. 6uvp: Bace-1 in Complex with Compound #3
  186. 3ooz: Bace1 in Complex with The Aminohydantoin Compound 102
  187. 3r2f: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with Bms-693391 Aka (2s)-2-((3r)-3-acetamido-3-isobutyl-2-oxo-1- Pyrrolidinyl)-n-((1s,2r)-1-(3,5-difluorobenzyl)-2-hydroxy-2-((2r,4r)- 4-propoxy-2-pyrrolidinyl)ethyl)-4-phenylbutanamide
  188. 3rsv: Structure of Bace-1 (beta-secretase) in Complex with (r)-3-(2-amino-6- O-tolylquinolin-3-yl)-n-((r)-2,2-dimethyltetrahydro-2h-pyran-4-yl)-2- Methylpropanamide
  189. 3rsx: Structure of Bace-1 (beta-secretase) in Complex with 6-(thiophen-3- Yl)quinolin-2-amine
  190. 3rth: Structure of Bace-1 (beta-secretase) in Complex with 6-(2-(3,3- Dimethylbut-1-ynyl)phenyl)quinolin-2-amine
  191. 3rtm: Structure of Bace-1 (beta-secretase) in Complex with 3-(2- Aminoquinolin-3-yl)-n-cyclohexyl-n-methylpropanamide
  192. 3rtn: Structure of Bace-1 (beta-secretase) in Complex with 3-(2-amino-6-o- Tolylquinolin-3-yl)-n-cyclohexylpropanamide
  193. 3ru1: Structure of Bace-1 (beta-secretase) in Complex with 3-(2- Aminoquinolin-3-yl)-n-(cyclohexylmethyl)propanamide
  194. 3rvi: Structure of Bace-1 (beta-secretase) in Complex with 2-((2-amino-6-o- Tolylquinolin-3-yl)methyl)-n-(cyclohexylmethyl)pentanamide
  195. 3s7l: Pyrazolyl and Thienyl Aminohydantoins as Potent Bace1 Inhibitors
  196. 3s7m: Pyrazolyl and Thienyl Aminohydantoins as Potent Bace1 Inhibitors
  197. 3skf: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with (2s)-2-((3s)-3-(acetylamino)-3-(butan-2-yl)-2-oxopyrrolidin-1- Yl)-n-((2s,3r)-3-hydroxy-4-((3-methoxybenzyl)amino)-1-phenylbutan-2- Yl)-4-phenylbutanamide
  198. 3skg: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with (2s)-2-((3r)-3-acetamido-3-isobutyl-2-oxo-1-pyrrolidinyl)-n- ((1s,2r)-1-(3,5-difluorobenzyl)-2-hydroxy-2-(1,2,3,4-tetrahydro-3- Isoquinolinyl)ethyl)-4-phenylbutanamide
  199. 3u6a: Rational Design and Synthesis of Aminopiperazinones as Beta Secretase (bace) Inhibitors
  200. 3tpj: Apo Structure of Bace1
  201. 3tpl: Apo Structure of Bace1
  202. 3tpp: Crystal Structure of Bace1 Complexed with an Inhibitor
  203. 3tpr: Crystal Structure of Bace1 Complexed with an Inhibitor
  204. 3ufl: Discovery of Pyrrolidine-based B-secretase Inhibitors: Lead Advancement through Conformational Design for Maintenance of Ligand Binding Efficiency
  205. 6pz4: Co-crystal Structure of Bace with Inhibitor Am-6494
  206. 4acu: Aminoimidazoles as Bace-1 Inhibitors. X-ray Crystal Structure of Beta Secretase Complexed with Compound 14
  207. 4acx: Aminoimidazoles as Bace-1 Inhibitors. X-ray Crystal Structure of Beta Secretase Complexed with Compound 23
  208. 6od6: Structure of Bace-1 in Complex with Ligand 13
  209. 4dju: Structure of Bace Bound to 2-imino-3-methyl-5,5-diphenylimidazolidin- 4-one
  210. 4djv: Structure of Bace Bound to 2-imino-5-(3'-methoxy-[1,1'-biphenyl]-3- Yl)-3-methyl-5-phenylimidazolidin-4-one
  211. 4djw: Structure of Bace Bound to 2-imino-3-methyl-5-phenyl-5-(3-(pyridin-3- Yl)phenyl)imidazolidin-4-one
  212. 4djx: Structure of Bace Bound to 5-(3-(5-chloropyridin-3-yl)phenyl)-5- Cyclopropyl-2-imino-3-methylimidazolidin-4-one
  213. 4djy: Structure of Bace Bound to (r)-5-cyclopropyl-2-imino-3-methyl-5-(3-(5- (prop-1-yn-1-yl)pyridin-3-yl)phenyl)imidazolidin-4-one
  214. 3qi1: Design and Synthesis of Hydroxyethylamine (hea) Bace-1 Inhibitors: Prime Side Chromane-containing Inhibitors
  215. 3udh: Crystal Structure of Bace with Compound 1
  216. 3udj: Crystal Structure of Bace with Compound 5
  217. 3udk: Crystal Structure of Bace with Compound 6
  218. 3udm: Crystal Structure of Bace with Compound 8
  219. 3udn: Crystal Structure of Bace with Compound 9
  220. 3udp: Crystal Structure of Bace with Compound 12
  221. 3udq: Crystal Structure of Bace with Compound 13
  222. 3udr: Crystal Structure of Bace with Compound 14
  223. 3udy: Crystal Structure of Bace with Compound 11
  224. 4dh6: Structure of Bace-1 (beta-secretase) in Complex with (2r)-n-((2s,3r)- 1-(benzo[d][1,3]dioxol-5-yl)-3-hydroxy-4-((s)-6'-neopentyl-3',4'- Dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridine]-4'-ylamino) Butan-2-yl)-2-methoxypropanamide
  225. 6nw3: Bace1 in Complex with a Macrocyclic Inhibitor
  226. 6nv9: Bace1 in Complex with a Macrocyclic Inhibitor
  227. 6nv7: Bace1 in Complex with a Macrocyclic Inhibitor
  228. 4dpf: Bace-1 in Complex with a Hea-macrocyclic Type Inhibitor
  229. 4dpi: Bace-1 in Complex with Hea-macrocyclic Inhibitor, Mv078512
  230. 4frs: Structure of Bace in Complex with (s)-4-(3-chloro-5-(5-(prop-1-yn-1- Yl)pyridin-3-yl)thiophen-2-yl)-1,4-dimethyl-6-oxotetrahydropyrimidin- 2(1h)-iminium
  231. 6jt3: Crystal Structure of Bace1 in Complex with N-{3-[(4r,5r,6r)-2-amino-5- Fluoro-4,6-dimethyl-5,6-dihydro-4h-1,3-thiazin-4-yl]-4-fluorophenyl}- 5-(fluoromethoxy)pyrazine-2-carboxamide
  232. 6jsn: Crystal Structure of Bace1 in Complex with N-{3-[(5r)-3-amino-5- Methyl-9,9-dioxo-2,9lambda6-dithia-4-azaspiro[5.5]undec-3-en-5-yl]-4- Fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide
  233. 6jsg: Crystal Structure of Bace1 in Complex with N-{3-[(4s)-2-amino-4- Methyl-5,6-dihydro-4h-1,3-thiazin-4-yl]-4-fluorophenyl}-5- Chloropyridine-2-carboxamide
  234. 6jsf: Crystal Structure of Bace1 in Complex with N-(3-((4s,5s)-2-amino-4- Methyl-5-phenyl-5,6-dihydro-4h-1,3-thiazin-4-yl)-4-fluorophenyl)-5- (fluoromethoxy)pyrazine-2-carboxamide
  235. 6jse: Crystal Structure of Bace1 in Complex with N-(3-((4s,5r)-2-amino-4- Methyl-5-phenyl-5,6-dihydro-4h-1,3-thiazin-4-yl)-4-fluorophenyl)-5- (fluoromethoxy)pyrazine-2-carboxamide
  236. 4fri: Crystal Structure of Bace1 in Complex with Biarylspiro Aminooxazoline 6
  237. 4frj: Crystal Structure of Bace1 in Complex with Aminooxazoline Xanthene 9l
  238. 4frk: Crystal Structure of Bace1 in Complex with Aminooxazoline Xanthene 11a
  239. 4azy: Design and Synthesis of Bace1 Inhibitors with in Vivo Brain Reduction of Beta-amyloid Peptides (compound 10)
  240. 4b00: Design and Synthesis of Bace1 Inhibitors with in Vivo Brain Reduction of Beta-amyloid Peptides (compound (r)-41)
  241. 4b05: Preclinical Characterization of Azd3839, a Novel Clinical Candidate Bace1 Inhibitor for The Treatment of Alzheimer Disease
  242. 4b1c: New Aminoimidazoles as Bace-1 Inhibitors: from Rational Design to Ab-lowering in Brain
  243. 4b1d: New Aminoimidazoles as Bace-1 Inhibitors: from Rational Design to Ab-lowering in Brain
  244. 4b1e: New Aminoimidazoles as Bace-1 Inhibitors: from Rational Design to Ab-lowering in Brain
  245. 4di2: Crystal Structure of Bace1 in Complex with Hydroxyethylamine Inhibitor 37
  246. 4dus: Structure of Bace-1 (beta-secretase) in Complex with N-((2s,3r)-1-(4- Fluorophenyl)-3-hydroxy-4-((6'-neopentyl-3',4'- Dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino) Butan-2-yl)acetamide
  247. 4fm7: Crystal Structure of Bace with Compound 14g
  248. 4fm8: Crystal Structure of Bace with Compound 12a
  249. 4fs4: Structure of Bace Bound to (s)-4-(3'-methoxy-[1,1'-biphenyl]-3-yl)-1, 4-dimethyl-6-oxotetrahydropyrimidin-2(1h)-iminium
  250. 4fse: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with N-(n-(4-amino-3,5- Dichlorobenzyl)carbamimidoyl)-3-(4- Methoxyphenyl)-5- Methyl-4-isothiazolecarboxamide
  251. 4fsl: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-db-mut) Complex with N-(n-(4- Acetamido-3-chloro-5-methylbenzyl) Carbamimidoyl)-3-(4- Methoxyphenyl)-5-methyl-4-isothiazolecarboxamide
  252. 4gid: Structure of Beta-secretase Complexed with Inhibitor
  253. 4h1e: Structure of Bace-1 Bound to (7ar)-6-benzoyl-7a-(4-(3-cyanophenyl) Thiophen-2-yl)-3-methyl-4-oxohexahydro-1h-pyrrolo[3,4-d]pyrimidin- 2(3h)-iminium
  254. 4h3j: Structure of Bace Bound to 2-fluoro-5-(5-(2-imino-3-methyl-4-oxo-6- Phenyloctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-2-yl) Benzonitrile
  255. 4ha5: Structure of Bace Bound to (s)-3-(5-(2-imino-1,4-dimethyl-6- Oxohexahydropyrimidin-4-yl)thiophen-3-yl)benzonitrile
  256. 3vv6: Crystal Structure of Beta Secetase in Complex with 2-amino-3-methyl-6- ((1s, 2r)-2-phenylcyclopropyl)pyrimidin-4(3h)-one
  257. 3vv7: Crystal Structure of Beta Secetase in Complex with 2-amino-6-((1s,2r)- 2-(3'-methoxybiphenyl-3-yl)cyclopropyl)-3-methylpyrimidin-4(3h)-one
  258. 3vv8: Crystal Structure of Beta Secetase in Complex with 2-amino-3-methyl-6- ((1s,2r)-2-(3'-methylbiphenyl-4-yl)cyclopropyl)pyrimidin-4(3h)-one
  259. 4ewo: Design and Synthesis of Potent Hydroxyethylamine (hea) Bace-1 Inhibitors
  260. 4exg: Design and Synthesis of Potent Hydroxyethylamine (hea) Bace-1 Inhibitors
  261. 3uqp: Crystal Structure of Bace1 with Its Inhibitor
  262. 3uqr: Crystal Structure of Bace1 with Its Inhibitor
  263. 3uqu: Crystal Structure of Bace1 with Its Inhibitor
  264. 3uqw: Crystal Structure of Bace1 with Its Inhibitor
  265. 3uqx: Crystal Structure of Bace1 with Its Inhibitor
  266. 3veu: Crystal Structure of Human Beta Secretase in Complex with Nvp-avi326
  267. 3vf3: Crystal Structure of Human Beta Secretase in Complex with Nvp-bqq711
  268. 3vg1: Crystal Structure of Human Beta Secretase in Complex with Nvp-bur436, Derived from a Soaking Experiment
  269. 4d83: Crystal Structure of Human Beta Secretase in Complex with Nvp-bur436, Derived from a Co-crystallization Experiment
  270. 4d85: Crystal Structure of Human Beta Secretase in Complex with Nvp-bvi151
  271. 4d88: Crystal Structure of Human Beta Secretase in Complex with Nvp-bxq490
  272. 4d89: Crystal Structure of Human Beta Secretase in Complex with Nvp-bxd552, Derived from a Soaking Experiment
  273. 4d8c: Crystal Structure of Human Beta Secretase in Complex with Nvp-bxd552, Derived from a Co-crystallization Experiment
  274. 4h3f: Structure of Bace Bound to 3-(5-((7ar)-2-imino-6-(6-methoxypyridin-2- Yl)-3-methyl-4-oxooctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl) Thiophen-3-yl)benzonitrile
  275. 4h3g: Structure of Bace Bound to 2-((7ar)-7a-(4-(3-cyanophenyl)thiophen-2- Yl)-2-imino-3-methyl-4-oxohexahydro-1h-pyrrolo[3,4-d]pyrimidin-6(2h)- Yl)nicotinonitrile
  276. 4h3i: Structure of Bace Bound to 3-(5-((7ar)-2-imino-6-(3-methoxypyridin-2- Yl)-3-methyl-4-oxooctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl) Thiophen-3-yl)benzonitrile
  277. 4dv9: Crystal Structure of Bace1 with Its Inhibitor
  278. 4dvf: Crystal Structure of Bace1 with Its Inhibitor
  279. 4fgx: Crystal Structure of Bace1 with Novel Inhibitor
  280. 4hzt: Structure-based Design of Novel Dihydroisoquinoline Bace-1 Inhibitors That Do Not Engage The Catalytic Aspartates
  281. 4i0e: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel Bace-1 Inhibitors
  282. 4i0f: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel Bace-1 Inhibitors
  283. 4i0g: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel Bace-1 Inhibitors
  284. 4i0h: Spr and Structural Analysis Yield Insight towards Mechanism of Inhibition of Bace Inhibitors.
  285. 4i0j: Spr and Structural Analysis Yield Insight towards Mechanism of Inhibition of Bace Inhibitors
  286. 4i0z: Structure-based Design of Novel Dihydroisoquinoline Bace-1 Inhibitors That Do Not Engage The Catalytic Aspartates
  287. 4i10: Structure-based Design of Novel Dihydroisoquinoline Bace-1 Inhibitors That Do Not Engage The Catalytic Aspartates
  288. 4i11: Structure-based Design of Novel Dihydroisoquinoline Bace-1 Inhibitors That Do Not Engage The Catalytic Aspartates.
  289. 4i12: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel Bace-1 Inhibitors
  290. 4i1c: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel Bace-1 Inhibitors
  291. 4joo: Spirocyclic Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
  292. 4jp9: Spirocyclic Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
  293. 4jpc: Spirocyclic Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
  294. 4jpe: Spirocyclic Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
  295. 3zmg: Crystal Structure of Bace-1 in Complex with Chemical Ligand
  296. 4j0t: Crystal Structure of Bace-1 in Complex with 5-ethoxy-pyridine-2- Carboxylic Acid [3-((r)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4h- [1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
  297. 4j0v: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4r,5r)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4h- [1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
  298. 4j0y: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4r,5s)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4h- [1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
  299. 4j0z: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4s,5r)-2-amino-5-fluoro-4-fluoromethyl-5,6- Dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
  300. 4j17: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((s)-2-amino-4-difluoromethyl-5,6-dihydro-4h-[1, 3]oxazin-4-yl)-4-fluoro-phenyl]-amide
  301. 4j1c: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((s)-2-amino-5,5-difluoro-4-fluoromethyl-5,6- Dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
  302. 4j1e: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4s,6s)-2-amino-4-fluoromethyl-6-trifluoromethyl- 5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
  303. 4j1f: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4s,6s)-2-amino-4-methyl-6-trifluoromethyl-5,6- Dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
  304. 4j1h: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4s,6r)-2-amino-4-methyl-6-trifluoromethyl-5,6- Dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
  305. 4j1i: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4r,5r,6r)-2-amino-5-fluoro-4-methyl-6- Trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]- Amide
  306. 4j1k: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((4r,5r,6s)-2-amino-5-fluoro-4-methyl-6- Trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]- Amide
  307. 3zov: Crystal Structure of Bace-1 in Complex with Chemical Ligand
  308. 4fco: Crystal Structure of Bace1 with Its Inhibitor
  309. 6fgy: Crystal Structure of Human Bace-1 in Complex with Amino-1,4-oxazine Compound 4
  310. 4bek: Crystal Structure of Bace-1 in Complex with Chemical Ligand
  311. 4bfd: Crystal Structure of Bace-1 in Complex with Chemical Ligand
  312. 4b70: Aminoimidazoles as Bace-1 Inhibitors: from De Novo Design to Ab-lowering in Brain
  313. 4b72: Aminoimidazoles as Bace-1 Inhibitors: from De Novo Design to Ab-lowering in Brain
  314. 4b77: Aminoimidazoles as Bace-1 Inhibitors: from De Novo Design to Ab-lowering in Brain
  315. 4b78: Aminoimidazoles as Bace-1 Inhibitors: from De Novo Design to Ab-lowering in Brain
  316. 4k8s: Hydroxyethylamine-based Inhibitors of Bace1: P1-p3 Macrocyclization Can Improve Potency, Selectivity, and Cell Activity
  317. 4k9h: Bace-1 Inhibitor Complex
  318. 4ke0: Crystal Structure of Bace1 in Complex with Hydroxyethylamine- Macrocyclic Inhibitor 13
  319. 4ke1: Crystal Structure of Bace1 in Complex with Hydroxyethylamine- Macrocyclic Inhibitor 19
  320. 4b0q: Lead Generation of Bace1 Inhibitors by Coupling Non-amidine New Warheads to a Known Binding Scaffold
  321. 6eqm: Crystal Structure of Human Bace-1 in Complex with Cnp520
  322. 6ej3: Bace1 Compound 23
  323. 6ej2: Bace1 Compound 28
  324. 6jt4: Crystal Structure of Bace1 in Complex with N-{3-[(4s,6s)-2-amino-4- Methyl-6-(trifluoromethyl)-5,6-dihydro-4h-1,3-thiazin-4-yl]-4- Fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide
  325. 6e3z: Structure of Bace-1 in Complex with Ligand 8
  326. 6dmi: A Multiconformer Ligand Model of 5t5 Bound to Bace-1
  327. 6dhc: X-ray Structure of Bace1 in Complex with a Bicyclic Isoxazoline Carboxamide as The P3 Ligand
  328. 3wb4: Crystal Structure of Beta Secetase in Complex with 2-amino-3,6- Dimethyl-6-(2-phenylethyl)-3,4,5,6-tetrahydropyrimidin-4-one
  329. 3wb5: Crystal Structure of Beta Secetase in Complex with (6s)-2-amino-3,6- Dimethyl-6-[(1r,2r)-2-phenylcyclopropyl]-3,4,5,6-tetrahydropyrimidin- 4-one
  330. 4gmi: Bace-1 in Complex with Hea-type Macrocyclic Inhibitor, Mv078571
  331. 4i0d: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel Bace-1 Inhibitors
  332. 4i0i: Spr and Structural Analysis Yield Insight towards Mechanism of Inhibition of Bace Inhibitors
  333. 4ivs: Crystal Structure of Bace1 with Its Inhibitor
  334. 4ivt: Crystal Structure of Bace1 with Its Inhibitor
  335. 4j0p: Crystal Structure of Bace-1 in Complex with 5-cyano-pyridine-2- Carboxylic Acid [3-((s)-2-amino-4-methyl-5,6-dihydro-4h-[1,3]oxazin- 4-yl)-4-fluoro-phenyl]-amide
  336. 4l7g: Diethylaminosulfur Trifluoride-mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity against Beta-secretase-1 (bace1)
  337. 4l7h: Diethylaminosulfur Trifluoride-mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity against Beta-secretase-1 (bace-1)
  338. 4l7j: Diethylaminosulfur Trifluoride-mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity against Beta-secretase-1 (bace-1)
  339. 4lc7: Aminooxazoline Inhibitor of Bace-1
  340. 4lxa: Crystal Structure of Human Beta Secretase in Complex with Compound 11a
  341. 4lxk: Crystal Structure of Human Beta Secretase in Complex with Compound 11d
  342. 4lxm: Crystal Structure of Human Beta Secretase in Complex with Compound 12a
  343. 4n00: Discovery of 7-thp Chromans: Bace1 Inhibitors That Reduce A-beta in The Cns
  344. 5ygy: Crystal Structure of Bace1 in Complex with (s)-n-(3-(2-amino-6- (fluoromethyl)-4 -methyl-4h-1,3-oxazin-4-yl)-4-fluorophenyl)-5- Cyanopicolinamide
  345. 5ygx: Structure of Bace1 in Complex with N-(3-((4r,5r,6s)-2-amino-6-(1,1- Difluoroethyl)-5-fluoro-4-methyl-5,6-dihydro-4h-1,3-oxazin-4-yl)-4- Fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide
  346. 4pzw: Synthesis, Characterization and Pk/pd Studies of a Series of Spirocyclic Pyranochromene Bace1 Inhibitors
  347. 4pzx: Synthesis, Characterization and Pk/pd Studies of a Series of Spirocyclic Pyranochromene Bace1 Inhibitors
  348. 4r8y: Bace-1 in Complex with (r)-4-(2-cyclohexylethyl)-4-(((r)-1-(2- Cyclopentylacetyl)pyrrolidin-3-yl)methyl)-1-methyl-5-oxoimidazolidin- 2-iminium
  349. 4r91: Bace-1 in Complex with (r)-4-(2-cyclohexylethyl)-4-(((1s,3r)-3- (cyclopentylamino)cyclohexyl)methyl)-1-methyl-5-oxoimidazolidin-2- Iminium
  350. 4r92: Bace-1 in Complex with (r)-4-(2-cyclohexylethyl)-4-(((1s,3r)-3- (isonicotinamido)cyclohexyl)methyl)-1-methyl-5-oxoimidazolidin-2- Iminium
  351. 4r93: Bace-1 in Complex with (r)-4-(2-cyclohexylethyl)-1-methyl-5-oxo-4- (((1s,3r)-3-(3-phenylureido)cyclohexyl)methyl)imidazolidin-2-iminium
  352. 4r95: Bace-1 in Complex with 2-(((1r,3s)-3-(((r)-4-(2-cyclohexylethyl)-2- Iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino) Quinolin-1-ium
  353. 5v0n: Bace1 in Complex with Inhibitor 5g
  354. 5uyu: Crystal Structure of Bace1 in Complex with 2-aminooxazoline-3- Azaxanthene Compound 12
  355. 4r5n: 8-tetrahydropyran-2-yl Chromans: Highly Selective Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
  356. 4rrn: 8-tetrahydropyran-2-yl Chromans: Highly Selective Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
  357. 4rro: 8-tetrahydropyran-2-yl Chromans: Highly Selective Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
  358. 4rrs: 8-tetrahydropyran-2-yl Chromans: Highly Selective Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
  359. 5tol: Crystal Structure of Beta-site App-cleaving Enzyme 1 Complexed with N- (3-((4as,7as)-2-amino-4,4a,5,6-tetrahydro-7ah-furo[2,3-d][1, 3]thiazin-7a-yl)-4-fluorophenyl)-5-bromo-2-pyridinecarboxamide
  360. 5t1w: Aminomethyl-derived Beta Secretase (bace1) Inhibitors: Engaging Gly230 without an Anilide Functionality
  361. 5t1u: Aminomethyl-derived Beta Secretase (bace1) Inhibitors: Engaging Gly230 without an Anilide Functionality
  362. 5mxd: Bace-1 in Complex with Ligand 32397778
  363. 5mcq: Crystal Structure of Bace-1 in Complex with Active Site and Exosite Binding Peptide Inhibitor
  364. 5mco: Crystal Structure of Bace-1 in Complex with Active Site Inhibitor Grl- 8234 and Exosite Peptide
  365. 5mbw: Crystal Structure of Bace-1 in Complex with Pep
  366. 5kr8: (4~{s},6~{s})-4-[2,4-bis(fluoranyl)phenyl]-6-(3,5-dimethyl-1,2-oxazol- 4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine (compound 5) Bound to Bace1
  367. 5kqf: (4~{s},6~{s})-4-[2,4-bis(fluoranyl)phenyl]-4-methyl-6-pyrimidin-5-yl- 5,6-dihydro-1,3-thiazin-2-amine (compound 12) Bound to Bace1
  368. 5ie1: Crystal Structure of Bace1 in Complex with 3-(2-amino-6-(o-tolyl) Quinolin-3-yl)-n-(3,3-dimethylbutyl)propanamide
  369. 5i3y: Crystal Structure of Bace1 in Complex with Aminoquinoline Inhibitor 9
  370. 5i3x: Crystal Structure of Bace1 in Complex with Aminoquinoline Inhibitor 6
  371. 5i3w: Crystal Structure of Bace1 in Complex with 2-aminooxazoline-3- Azaxanthene Inhibitor 2
  372. 5i3v: Crystal Structure of Bace1 in Complex with Aminoquinoline Compound 1
  373. 5hu1: Bace1 in Complex with (r)-n-(3-(3-amino-2,5-dimethyl-1,1-dioxido-5,6- Dihydro-2h-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5- Fluoropicolinamide
  374. 5hu0: Bace1 in Complex with 4-(3-(furan-2-carboxamido)phenyl)-1-methyl-5- Oxo-4-phenylimidazolidin-2-iminium
  375. 5htz: Bace1 in Complex with (s)-5-(3-chloro-5-(5-(prop-1-yn-1-yl)pyridin-3- Yl)thiophen-2-yl)-2,5-dimethyl-1,2,4-thiadiazinan-3-iminium 1,1- Dioxide
  376. 5he7: Bace-1 in Complex with (4ar,7as)-7a-(2,4-difluorophenyl)-6-(5-fluoro- 4-methoxy-6-methylpyrimidin-2-yl)-2-imino-3-methyloctahydro-4h- Pyrrolo[3,4-d]pyrimidin-4-one
  377. 5he5: Bace-1 in Complex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4- Methyl-6-(methylamino)pyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h- Pyrrolo[3,4-d]pyrimidin-2-iminium
  378. 5he4: Bace-1 in Complex with (4ar,7as)-7a-(2,6-difluorophenyl)-6-(5-fluoro- 4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h- Pyrrolo[3,4-d]pyrimidin-2-iminium
  379. 5hdz: Bace-1 in Complex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4- Methyl-6-(methylthio)pyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h- Pyrrolo[3,4-d]pyrimidin-2-iminium
  380. 5hdx: Bace-1 in Complex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(4-ethoxy-5- Fluoro-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3, 4-d]pyrimidin-2-iminium
  381. 5hdv: Bace-1 Incomplex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4- Methoxy-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3, 4-d]pyrimidin-2-iminium
  382. 5hdu: Bace-1 Incomplex with (7ar)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-6-(5- Fluoro-4-methoxypyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3, 4-d]pyrimidin-2-iminium
  383. 5hd0: Bace-1 in Complex with (7ar)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-6-(5- Fluoropyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4- D]pyrimidin-2-iminium
  384. 5f01: Crystal Structure of Bace-1 in Complex with (1sr,2sr)-2-((r)-2-amino- 5,5-difluoro-4-methyl-5,6-dihydro-4h-1,3-oxazin-4-yl)-n-(3- Chloroquinolin-8-yl)cyclopropanecarboxamide
  385. 5f00: Crystal Structure of Bace-1 in Complex with 5-[3-[(3-chloro-8- Quinolyl)amino]phenyl]-5-methyl-2,6-dihydro-1,4-oxazin-3-amine
  386. 5ezz: Crystal Structure of Bace-1 in Complex with (4s)-4-[3-(5-chloro-3- Pyridyl)phenyl]-4-[4-(difluoromethoxy)-3-methyl-phenyl]-5h-oxazol-2- Amine
  387. 5ezx: Crystal Structure of Bace-1 in Complex with {(1r,2r)-2-[(r)-2-amino-4- (4-difluoromethoxy-phenyl)-4,5-dihydro-oxazol-4-yl]-cyclopropyl}-(5- Chloro-pyridin-3-yl)-methanone
  388. 5enm: Compound 10
  389. 5enk: Compound 18
  390. 5dqc: Co-crystal of Bace1 with Compound 0211
  391. 5clm: 1,4-oxazine Bace1 Inhibitors
  392. 4rce: Crystal Structure of Bace1 in Complex with Aminooxazoline Xanthene Inhibitor 2
  393. 4rcf: Crystal Structure of Bace1 in Complex with 2-aminooxazoline 4- Fluoroxanthene Inhibitor 49
  394. 4x7i: Crystal Structure of Bace with Amino Thiazine Inhibitor Ly2886721
  395. 4rcd: Crystal Structure of Bace1 in Complex with a 2-aminooxazoline 4- Azaxanthene Inhibitor
  396. 4xkx: Crystal Structure of Bace1 in Complex with 2-aminooxazoline 3- Azaxanthene Inhibitor 28
  397. 4zsr: Bace Crystal Structure with Tricyclic Aminothiazine Inhibitor
  398. 4zsq: Bace Crystal Structure with Tricyclic Aminothiazine Inhibitor
  399. 4zsp: Bace Crystal Structure with Bicyclic Aminothiazine Inhibitor
  400. 4zsm: Bace Crystal Structure with Bicyclic Aminothiazine Fragment
  401. 4zpg: Bace1 in Complex with 8-benzyl-4-(cyclohexylamino)-1-(3-fluorophenyl)- 7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one
  402. 4zpf: Bace1 in Complex with 8-(3-((1-aminopropan-2-yl)oxy)benzyl)-4- (cyclohexylamino)-1-(3-fluorophenyl)-1,3,8-triazaspiro[4.5]dec-3-en- 2-one
  403. 4zpe: Bace1 in Complex with 4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3- Isopropoxybenzyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one
  404. 4wtu: Crystal Structure of Bace1 in Complex with 2-aminooxazoline 3-aza-4- Fluoro-xanthene Inhibitor 22
  405. 4wy1: Crystal Structure of Human Bace-1 Bound to Compound 24b
  406. 4wy6: Crystal Structure of Human Bace-1 Bound to Compound 36
  407. 4x2l: Crystal Structure of Human Bace-1 Bound to Compound 6
  408. 4xxs: Crystal Structure of Bace1 with a Pyrazole-substituted Tetrahydropyran Thioamidine
  409. 4ybi: Crystal Structure of Bace with Amino Thiazine Inhibitor Ly2811376
  410. 4trw: Structure of Bace1 Complex with a Syn-hea-type Inhibitor
  411. 4try: Structure of Bace1 Complex with a Hea-type Inhibitor
  412. 4trz: Structure of Bace1 Complex with 2-thiophenyl Hea-type Inhibitor
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