EC 3.5.1.98 - histone amidohydrolase (histone deacetylase)

3D structures of EC 3.5.1.98 - histone deacetylase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 3mz7: Crystal Structure of D101L Co2+ Hdac8 Complexed with M344
2. 3mz6: Crystal Structure of D101L Fe2+ Hdac8 Complexed with M344
3. 3mz4: Crystal Structure of D101L Mn2+ Hdac8 Complexed with M344
4. 3mz3: Crystal Structure of Co2+ Hdac8 Complexed with M344
5. 3max: Crystal Structure of Human Hdac2 Complexed with an N-(2-aminophenyl) Benzamide
6. 3gv4: Crystal Structure of Human Hdac6 Zinc Finger Domain and Ubiquitin C-terminal Peptide Rlrgg
7. 3f0r: Crystal Structure Analysis of Human Hdac8 Complexed with Trichostatin a in a New Monoclinic Crystal Form
8. 3f07: Crystal Structure Analysis of Human Hdac8 Complexed with Apha in a New Monoclinic Crystal Form
9. 3f06: Crystal Structure Analysis of Human Hdac8 D101A Variant.
10. 3ezt: Crystal Structure Analysis of Human Hdac8 D101E Variant
11. 3ezp: Crystal Structure Analysis of Human Hdac8 D101N Variant
12. 3ewf: Crystal Structure Analysis of Human Hdac8 H143A Variant Complexed with Substrate.
13. 3ew8: Crystal Structure Analysis of Human Hdac8 D101L Variant
14. 2vqw: Structure of Inhibitor-free Hdac4 Catalytic Domain (with Gain-of-function Mutation HIS332TYR)
15. 7jvw: Crystal Structure of Human Histone Deacetylase 8 (hdac8) G320R Mutation Complexed with M344
16. 7jvv: Crystal Structure of Human Histone Deacetylase 8 (hdac8) E66D/Y306F Double Mutation Complexed with a Tetrapeptide Substrate
17. 7jvu: Crystal Structure of Human Histone Deacetylase 8 (hdac8) I45T Mutation Complexed with Saha
18. 7aoa: Structure of The Extended Mta1/hdac1/mbd2/rbbp4 Nurd Deacetylase Complex
19. 7ao9: Structure of The Core Mta1/hdac1/mbd2 Nurd Deacetylase Complex
20. 7ao8: Structure of The Mta1/hdac1/mbd2 Nurd Deacetylase Complex
21. 6z2k: The Structure of The Tetrameric Hdac1/mideas/dnttip1 Midac Deacetylase Complex
22. 6z2j: The Structure of The Dimeric Hdac1/mideas/dnttip1 Midac Deacetylase Complex
23. 5zop: Crystal Structure of Histone Deacetylase 4 (hdac4) in Complex with a Smrt Corepressor Sp2 Fragment
24. 5zoo: Crystal Structure of Histone Deacetylase 4 (hdac4) in Complex with a Smrt Corepressor Sp1 Fragment
25. 6xec: Structure of Human Hdac2 in Complex with Ketone Inhibitor (compound O)
26. 6xeb: Structure of Human Hdac2 in Complex with Ketone Inhibitor (compound E)
27. 6xdm: Structure of Human Hdac2 in Complex with an Aryl Ketone Inhibitor
28. 3phd: Crystal Structure of Human Hdac6 in Complex with Ubiquitin
29. 6wbz: Structure of Human Hdac2 in Complex with an Ethyl Ketone Inhibitor Containing a Spiro-bicyclic Group
30. 6wbw: Structure of Human Hdac2 in Complex with an Ethyl Ketone Inhibitor
31. 6odc: Crystal Structure of Hdac8 in Complex with Compound 30
32. 6odb: Crystal Structure of Hdac8 in Complex with Compound 3
33. 6oda: Crystal Structure of Hdac8 in Complex with Compound 2
34. 3sff: Crystal Structure of Human Hdac8 Inhibitor Complex, an Amino Acid Derived Inhibitor
35. 3sfh: Crystal Structure of Human Hdac8 Inhibitor Complex, an Amino Acid Derived Inhibitor
36. 3rqd: Ideal Thiolate-zinc Coordination Geometry in Depsipeptide Binding to Histone Deacetylase 8
37. 4a69: Structure of Hdac3 Bound to Corepressor and Inositol Tetraphosphate
38. 3uzd: Crystal Structure of 14-3-3 Gamma
39. 3v31: Crystal Structure of The Peptide Bound Complex of The Ankyrin Repeat Domains of Human Ankra2
40. 3uxg: Crystal Structure of Rfxank
41. 6hu3: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with a Triazole Hydroxamate Inhibitor
42. 6hu2: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with a Benzohydroxamate Inhibitor 11
43. 6hu1: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with a Benzohydroxamate Inhibitor 10
44. 6hu0: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with a Benzohydroxamate Inhibitor 9
45. 6htz: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with a Benzohydroxamate Inhibitor 8
46. 6htt: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with a Benzohydroxamate Inhibitor 7
47. 6hti: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with a Benzohydroxamate Inhibitor 6
48. 6hth: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with a Benzohydroxamate Inhibitor 5
49. 6htg: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with a Benzohydroxamate Inhibitor 4
50. 6ht8: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with a Benzohydroxamate Inhibitor 3
51. 6hsz: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with a Benzohydroxamate Inhibitor 2
52. 6hsk: Crystal Structure of a Human Hdac8 L6 Loop Mutant Complexed with Quisinostat
53. 6hsh: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with Quisinostat
54. 6hsg: Crystal Structure of Schistosoma Mansoni Hdac8 H292M Mutant Complexed with Ncc-149
55. 6hsf: Crystal Structure of Schistosoma Mansoni Hdac8 Mutant H292M Complexed with Pci-34051
56. 6hrq: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with Ncc-149
57. 6hqy: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with Pci- 34051
58. 3znr: Hdac7 Bound with Inhibitor Tmp269
59. 3zns: Hdac7 Bound with Tfmo Inhibitor Tmp942
60. 6gxw: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with an Hydroxamate 4
61. 6gxu: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with an Hydroxamate 3
62. 6gxa: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with an Hydroxamate 2
63. 6gx3: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with an Hydroxamate 1
64. 6g3o: Crystal Structure of Human Hdac2 in Complex with (r)-6-[3,4-dioxo-2- (4-trifluoromethoxy-phenylamino)-cyclobut-1-enylamino]-heptanoic Acid Hydroxyamide
65. 6fyz: Development and Characterization of a Cns-penetrant Benzhydryl Hydroxamic Acid Class Iia Histone Deacetylase Inhibitor
66. 6fu1: Crystal Structure of Schistosoma Mansoni Hdac8 Complexed with a N- Alkyl Hydroxamate
67. 4bkx: The Structure of Hdac1 in Complex with The Dimeric Elm2-sant Domain of Mta1 from The Nurd Complex
68. 6cef: Crystal Structure of Fragment 3-(1,3-benzothiazol-2-yl)propanoic Acid Bound in The Ubiquitin Binding Pocket of The Hdac6 Zinc-finger Domain
69. 6cee: Crystal Structure of Fragment 3-(1-methyl-2-oxo-1,2-dihydroquinoxalin- 3-yl)propionic Acid Bound in The Ubiquitin Binding Pocket of The Hdac6 Zinc-finger Domain
70. 6ced: Crystal Structure of Fragment 3-(3-methyl-4-oxo-3,4-dihydroquinazolin- 2-yl)propanoic Acid Bound in The Ubiquitin Binding Pocket of The Hdac6 Zinc-finger Domain
71. 6cec: Crystal Structure of Fragment 3-(3-methoxy-2-quinoxalinyl)propanoic Acid Bound in The Ubiquitin Binding Pocket of The Hdac6 Zinc-finger Domain
72. 6cea: Crystal Structure of Fragment 3-(quinolin-2-yl)propanoic Acid Bound in The Ubiquitin Binding Pocket of The Hdac6 Zinc-finger Domain
73. 6ce8: Crystal Structure of Fragment 2-(benzo[d]thiazol-2-yl)acetic Acid Bound in The Ubiquitin Binding Pocket of The Hdac6 Zinc-finger Domain
74. 6ce6: Structure of Hdac6 Zinc-finger Ubiquitin Binding Domain Soaked with 3, 3'-(benzo[1,2-d:5,4-d']bis(thiazole)-2,6-diyl)dipropionic Acid
75. 4cbt: Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors as a Potential Therapy for Huntingtons Disease
76. 4cby: Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors as a Potential Therapy for Huntingtons Disease
77. 4lxz: Structure of Human Hdac2 in Complex with Saha (vorinostat)
78. 4ly1: Structure of Human Hdac2 in Complex with Inhibitor 4-(acetylamino)-n- [2-amino-5-(thiophen-2-yl)phenyl]benzamide
79. 4qa0: Crystal Structure of C153F Hdac8 in Complex with Saha
80. 4qa1: Crystal Structure of A188T Hdac8 in Complex with M344
81. 4qa2: Crystal Structure of I243N Hdac8 in Complex with Saha
82. 4qa3: Crystal Structure of T311M Hdac8 in Complex with Trichostatin a (tsa)
83. 4qa4: Crystal Structure of H334R Hdac8 in Complex with M344
84. 4qa5: Crystal Structure of A188T/Y306F Hdac8 in Complex with a Tetrapeptide Substrate
85. 4qa6: Crystal Structure of I243N/Y306F Hdac8 in Complex with a Tetrapeptide Substrate
86. 4qa7: Crystal Structure of H334R/Y306F Hdac8 in Complex with a Tetrapeptide Substrate
87. 5wpb: Crystal Structure of Fragment 3-(3-(pyridin-2-ylmethoxy)quinoxalin-2- Yl)propanoic Acid Bound in The Ubiquitin Binding Pocket of The Hdac6 Zinc-finger Domain
88. 5wbn: Crystal Structure of Fragment 3-(3-benzyl-2-oxo-2h-[1,2,4]triazino[2, 3-c]quinazolin-6-yl)propanoic Acid Bound in The Ubiquitin Binding Pocket of The Hdac6 Zinc-finger Domain
89. 6pzo: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Yx-153
90. 6pzr: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Resminostat
91. 6pzs: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Jr005
92. 6j6t: Crystal Structure of Hda15 Hd Domain
93. 5vi6: Crystal Structure of Histone Deacetylase 8 in Complex with Trapoxin a
94. 5thv: Crystal Structure of G305A Hdac8 in Complex with M344
95. 5thu: Crystal Structure of G304A Hdac8 in Complex with M344
96. 5tht: Crystal Structure of G303A Hdac8 in Complex with M344
97. 5ths: Crystal Structure of G302A Hdac8 in Complex with M344
98. 5kh9: Crystal Structure of a Low Occupancy Fragment Candidate (5-[(4- Isopropylphenyl)amino]-6-methyl-1,2,4-triazin-3(2h)-one) Bound in The Ubiquitin Binding Pocket of The Hdac6 Zinc-finger Domain
99. 5kh7: Crystal Structure of Fragment (3-[6-oxo-3-(3-pyridinyl)-1(6h)- Pyridazinyl]propanoic Acid) Bound in The Ubiquitin Binding Pocket of The Hdac6 Zinc-finger Domain
100. 5kh3: Crystal Structure of Fragment (3-(5-chloro-1,3-benzothiazol-2-yl) Propanoic Acid) Bound in The Ubiquitin Binding Pocket of The Hdac6 Zinc-finger Domain
101. 5j8j: A Histone Deacetylase from Saccharomyces Cerevisiae
102. 5ix0: Hdac2 with Ligand Brd7232
103. 5iwg: Hdac2 with Ligand Brd4884
104. 5ikk: Structure of The Histone Deacetylase Clr3
105. 5icn: Hdac1:mta1 in Complex with Inositol-6-phosphate and a Novel Peptide Inhibitor Based on Histone H4
106. 5fcw: Hdac8 Complexed with a Hydroxamic Acid
107. 5efn: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 (H574A) in Complex with Histone H4 Lys6 Tripeptide Substrate
108. 5efk: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 (Y745F Mutant) in Complex with Alpha Tubulin K40 Tripeptide Substrate
109. 5efj: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 in Complex with Hc Toxin
110. 5efh: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 in Complex with Trifluoroketone Transition State Analogue
111. 5efg: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 in Complex with Acetate
112. 5efb: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 in Complex with Oxamflatin
113. 5ef8: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 in Complex with Panobinostat
114. 5ef7: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 in Complex with Hpob
115. 5een: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 in Complex with Belinostat
116. 5eem: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2
117. 5eek: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 in Complex with Trichostatin a
118. 5eei: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 in Complex with Saha
119. 5edu: Crystal Structure of Human Histone Deacetylase 6 Catalytic Domain 2 in Complex with Trichostatin a
120. 5dc8: Crystal Structure of H142A-Y306F Hdac8 in Complex with a Tetrapeptide Substrate
121. 5dc7: Crystal Structure of D176A-Y306F Hdac8 in Complex with a Tetrapeptide Substrate
122. 5dc6: Crystal Structure of D176N-Y306F Hdac8 in Complex with a Tetrapeptide Substrate
123. 5dc5: Crystal Structure of D176N Hdac8 in Complex with M344
124. 5d1d: Crystal Structure of P91L-Y306F Hdac8 in Complex with a Tetrapeptide Substrate
125. 5d1c: Crystal Structure of D233G-Y306F Hdac8 in Complex with a Tetrapeptide Substrate
126. 5d1b: Crystal Structure of G117E Hdac8 in Complex with Tsa
127. 5bwz: Crystal Structure of S39E Hdac8 in Complex with Droxinostat
128. 5b8d: Crystal Structure of a Low Occupancy Fragment Candidate (n-(4-methyl- 1,3-thiazol-2-yl)propanamide) Bound Adjacent to The Ubiquitin Binding Pocket of The Hdac6 Zinc-finger Domain
129. 5a2s: Potent, Selective and Cns-penetrant Tetrasubstituted Cyclopropane Class Iia Histone Deacetylase (hdac) Inhibitors
130. 4rn0: Crystal Structure of S39D Hdac8 in Complex with a Largazole Analogue.
131. 4rn1: Crystal Structure of S39D Hdac8 in Complex with a Largazole Analogue.
132. 4rn2: Crystal Structure of S39D Hdac8 in Complex with a Largazole Analogue.
133. 7kbg: Structure of Human Hdac2 in Complex with a 2-substituted Benzamide Inhibitor (compound 20)
134. 7kbh: Structure of Human Hdac2 in Complex with a 2-substituted Benzamide Inhibitor (compound 16)
135. 6z6f: Hdac-pc
136. 6z6h: Hdac-dc
137. 6z6o: Hdac-tc
138. 6z6p: Hdac-pc-nuc
139. 6whn: Histone Deacetylases Complex with Peptide Macrocycles
140. 6who: Histone Deacetylases Complex with Peptide Macrocycles
141. 6whq: Histone Deacetylases Complex with Peptide Macrocycles
142. 6whz: Histone Deacetylases Complex with Peptide Macrocycles
143. 6wi3: Histone Deacetylases Complex with Peptide Macrocycles
144. 7ltg: Structure of Human Hdac2 in Complex with Apicidin
145. 7ltk: Structure of Human Hdac2 in Complex with an Inhibitor That Lacks a Zinc Binding Group (compound 12)
146. 7ltl: Structure of Human Hdac2 in Complex with an Inhibitor Lacking a Zinc Binding Group (compound 19)
147. 7mos: Structure of Hdac2 in Complex with a Macrocyclic Inhibitor (compound 4)
148. 7mot: Structure of Hdac2 in Complex with an Inhibitor (compound 9)
149. 7mox: Structure of Hdac2 in Complex with an Inhibitor (compound 14)
150. 7moy: Structure of Hdac2 in Complex with an Inhibitor (compound 19)
151. 7moz: Structure of Hdac2 in Complex with a Macrocyclic Inhibitor (compound 25)
152. 7js8: Structure of Human Hdac2 in Complex with an Ethyl Ketone Inhibitor Containing a Spiro-bicyclic Group (compound 22)