EC 2.7.1.137 - ATP:1- phosphatidyl- 1D- myo- inositol 3- phosphotransferase (phosphatidylinositol 3- kinase)

3D structures of EC 2.7.1.137 - phosphatidylinositol 3-kinase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1e7u: Structure Determinants of Phosphoinositide 3-kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine
2. 1e7v: Structure Determinants of Phosphoinositide 3-kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine
3. 1e8w: Structure Determinants of Phosphoinositide 3-kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine
4. 1e8x: Structural Insights into Phoshoinositide 3-kinase Enzymatic Mechanism and Signalling
5. 1e8y: Structure Determinants of Phosphoinositide 3-kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine
6. 1e8z: Structure Determinants of Phosphoinositide 3-kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine
7. 1e90: Structure Determinants of Phosphoinositide 3-kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine
8. 1he8: Ras G12V - Pi 3-kinase Gamma Complex
9. 3ls8: Crystal Structure of Human PIK3C3 in Complex with 3-[4-(4- Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol
10. 1pic: Phosphatidylinositol 3-kinase, P85-alpha Subunit: C- Terminal Sh2 Domain Complexed with a Tyr751 Phosphopeptide from The Pdgf Receptor, Nmr, Minimized Mean Structure
11. 1pks: Structure of The PI3K Sh3 Domain and Analysis of The Sh3 Family
12. 1pkt: Structure of The PI3K Sh3 Domain and Analysis of The Sh3 Family
13. 3ihy: Human PIK3C3 Crystal Structure
14. 1w1n: The Solution Structure of The Fatc Domain of The Protein Kinase Tor1 from Yeast
15. 2x6k: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with Pi-103
16. 2x6j: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with Pik-93
17. 2x6i: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with Pik-90
18. 2x6h: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34
19. 2x6f: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with 3-methyladenine
20. 2chw: A Pharmacological Map of The Pi3-k Family Defines a Role for P110 Alpha in Signaling: The Structure of Complex of Phosphoinositide 3-kinase Gamma with Inhibitor Pik-39
21. 2chx: A Pharmacological Map of The Pi3-k Family Defines a Role for P110ALPHA in Signaling: The Structure of Complex of Phosphoinositide 3-kinase Gamma with Inhibitor Pik-90
22. 2chz: A Pharmacological Map of The Pi3-k Family Defines a Role for P110ALPHA in Signaling: The Structure of Complex of Phosphoinositide 3-kinase Gamma with Inhibitor Pik-93
23. 2pnb: Structure of an Sh2 Domain of The P85 Alpha Subunit of Phosphatidylinositol-3-oh Kinase
24. 2pna: Structure of an Sh2 Domain of The P85 Alpha Subunit of Phosphatidylinositol-3-oh Kinase
25. 2iwl: Structure of The Px Domain of Phosphoinositide 3-kinase- C2ALPHA
26. 3zvv: Fragment Bound to PI3KINASE Gamma
27. 4anu: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
28. 4anv: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
29. 4anw: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
30. 4anx: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
31. 6i3u: Optimization of Potent and Selective Atm Inhibitors Suitable for a Proof-of-concept Study in Huntington's Disease Models
32. 6hoh: Structure of Vps34 Lir Motif (S249E) Bound to Gabarap
33. 6hog: Structure of Vps34 Lir Motif Bound to Gabarap
34. 4oys: Crystal Structure of Vps34 in Complex with Sar405.
35. 4ph4: The Crystal Structure of Human Vps34 in Complex with Pik-iii
36. 4uwf: Discovery of (2s)-8-((3r)-3-methylmorpholin-4-yl)-1-(3- Methyl-2-oxo-butyl)-2-(trifluoromethyl)-3,4-dihydro-2h- Pyrimido(1,2-a)pyrimidin-6-one: a Novel Potent and Selective Inhibitor of Vps34 for The Treatment of Solid Tumors
37. 4uwg: Discovery of (2s)-8-((3r)-3-methylmorpholin-4-yl)-1-(3- Methyl-2-oxo-butyl)-2-(trifluoromethyl)-3,4-dihydro-2h- Pyrimido(1,2-a)pyrimidin-6-one: a Novel Potent and Selective Inhibitor of Vps34 for The Treatment of Solid Tumors
38. 4uwh: Discovery of (2s)-8-((3r)-3-methylmorpholin-4-yl)-1-(3- Methyl-2-oxo-butyl)-2-(trifluoromethyl)-3,4-dihydro-2h- Pyrimido(1,2-a)pyrimidin-6-one: a Novel Potent and Selective Inhibitor of Vps34 for The Treatment of Solid Tumors
39. 4uwk: Discovery of (2s)-8-((3r)-3-methylmorpholin-4-yl)-1-(3- Methyl-2-oxo-butyl)-2-(trifluoromethyl)-3,4-dihydro-2h- Pyrimido(1,2-a)pyrimidin-6-one: a Novel Potent and Selective Inhibitor of Vps34 for The Treatment of Solid Tumors
40. 4uwl: Discovery of (2s)-8-((3r)-3-methylmorpholin-4-yl)-1-(3- Methyl-2-oxo-butyl)-2-(trifluoromethyl)-3,4-dihydro-2h- Pyrimido(1,2-a)pyrimidin-6-one: a Novel Potent and Selective Inhibitor of Vps34 for The Treatment of Solid Tumors
41. 5kc2: Negative Stain Structure of Vps15/vps34 Complex
42. 5g55: 3-quinoline Carboxamides Inhibitors of PI3K
43. 5g2n: X-ray Structure of PI3KINASE Gamma in Complex with Copanlisib
44. 5enn: The Crystal Structure of Human Vps34 in Complex with a Selective and Potent Inhibitor
45. 5dfz: Structure of Vps34 Complex II from S. Cerevisiae.
46. 5anl: Crystal Structure of Vps34 in Complex with (2s)-8-((3r)-3- Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- Butyl)-2-( Trifluoromethyl)-3,4-dihydro-2h-pyrimido(1,2-a)pyrimidin-6- One, Processed with The Crystaldirect Automated Mounting and Cryo-cooling Technology
47. 7mez: Structure of The Phosphoinositide 3-kinase P110 Gamma (PIK3CG) P101 (PIK3R5) Complex
48. 7rsj: Structure of The Vps34 Kinase Domain with Compound 14
49. 7rsp: Structure of The Vps34 Kinase Domain with Compound 14
50. 7rsv: Structure of The Vps34 Kinase Domain with Compound 5