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enzyme (lysozyme)

 
Enzymes
  Enzyme classes:
  EC 1: Oxidoreductases
  EC 2: Transferases
    EC 2.1
    EC 2.2
    EC 2.3
    EC 2.4
    EC 2.5
    EC 2.6
    EC 2.7
      EC 2.7.1
        EC 2.7.1.1
        EC 2.7.1.2
        EC 2.7.1.3
        EC 2.7.1.4
        EC 2.7.1.5
        EC 2.7.1.6
        EC 2.7.1.7
        EC 2.7.1.8
        EC 2.7.1.9
        EC 2.7.1.10
        EC 2.7.1.11
        EC 2.7.1.12
        EC 2.7.1.13
        EC 2.7.1.14
        EC 2.7.1.15
        EC 2.7.1.16
        EC 2.7.1.17
        EC 2.7.1.18
        EC 2.7.1.19
        EC 2.7.1.20
        EC 2.7.1.21
        EC 2.7.1.22
        EC 2.7.1.23
        EC 2.7.1.24
        EC 2.7.1.25
        EC 2.7.1.26
        EC 2.7.1.27
        EC 2.7.1.28
        EC 2.7.1.29
        EC 2.7.1.30
        EC 2.7.1.31
        EC 2.7.1.32
        EC 2.7.1.33
        EC 2.7.1.34
        EC 2.7.1.35
        EC 2.7.1.36
        EC 2.7.1.37
        EC 2.7.1.38
        EC 2.7.1.39
        EC 2.7.1.40
        EC 2.7.1.41
        EC 2.7.1.42
        EC 2.7.1.43
        EC 2.7.1.44
        EC 2.7.1.45
        EC 2.7.1.46
        EC 2.7.1.47
        EC 2.7.1.48
        EC 2.7.1.49
        EC 2.7.1.50
        EC 2.7.1.51
        EC 2.7.1.52
        EC 2.7.1.53
        EC 2.7.1.54
        EC 2.7.1.55
        EC 2.7.1.56
        EC 2.7.1.57
        EC 2.7.1.58
        EC 2.7.1.59
        EC 2.7.1.60
        EC 2.7.1.61
        EC 2.7.1.62
        EC 2.7.1.63
        EC 2.7.1.64
        EC 2.7.1.65
        EC 2.7.1.66
        EC 2.7.1.67
        EC 2.7.1.68
        EC 2.7.1.69
        EC 2.7.1.70
        EC 2.7.1.71
        EC 2.7.1.72
        EC 2.7.1.73
        EC 2.7.1.74
        EC 2.7.1.75
        EC 2.7.1.76
        EC 2.7.1.77
        EC 2.7.1.78
        EC 2.7.1.79
        EC 2.7.1.80
        EC 2.7.1.81
        EC 2.7.1.82
        EC 2.7.1.83
        EC 2.7.1.84
        EC 2.7.1.85
        EC 2.7.1.86
        EC 2.7.1.87
        EC 2.7.1.88
        EC 2.7.1.89
        EC 2.7.1.90
        EC 2.7.1.91
        EC 2.7.1.92
        EC 2.7.1.93
        EC 2.7.1.94
        EC 2.7.1.95
        EC 2.7.1.96
        EC 2.7.1.97
        EC 2.7.1.98
        EC 2.7.1.99
        EC 2.7.1.100
        EC 2.7.1.101
        EC 2.7.1.102
        EC 2.7.1.103
        EC 2.7.1.104
        EC 2.7.1.105
        EC 2.7.1.106
        EC 2.7.1.107
        EC 2.7.1.108
        EC 2.7.1.109
        EC 2.7.1.110
        EC 2.7.1.111
        EC 2.7.1.112
        EC 2.7.1.113
        EC 2.7.1.114
        EC 2.7.1.115
        EC 2.7.1.116
        EC 2.7.1.117
        EC 2.7.1.118
        EC 2.7.1.119
        EC 2.7.1.120
        EC 2.7.1.121
        EC 2.7.1.122
        EC 2.7.1.123
        EC 2.7.1.124
        EC 2.7.1.125
        EC 2.7.1.126
        EC 2.7.1.127
        EC 2.7.1.128
        EC 2.7.1.129
        EC 2.7.1.130
        EC 2.7.1.131
        EC 2.7.1.132
        EC 2.7.1.133
        EC 2.7.1.134
        EC 2.7.1.135
        EC 2.7.1.136
        EC 2.7.1.137
        EC 2.7.1.138
        EC 2.7.1.139
        EC 2.7.1.140
        EC 2.7.1.141
        EC 2.7.1.142
        EC 2.7.1.143
        EC 2.7.1.144
        EC 2.7.1.145
        EC 2.7.1.146
        EC 2.7.1.147
        EC 2.7.1.148
        EC 2.7.1.149
        EC 2.7.1.150
        EC 2.7.1.151
        EC 2.7.1.152
        EC 2.7.1.153
        EC 2.7.1.154
        EC 2.7.1.155
        EC 2.7.1.156
        EC 2.7.1.157
        EC 2.7.1.158
        EC 2.7.1.159
        EC 2.7.1.160
        EC 2.7.1.161
        EC 2.7.1.162
      EC 2.7.2
      EC 2.7.3
      EC 2.7.4
      EC 2.7.5
      EC 2.7.6
      EC 2.7.7
      EC 2.7.8
      EC 2.7.9
      EC 2.7.10
      EC 2.7.11
      EC 2.7.12
      EC 2.7.13
      EC 2.7.14
    EC 2.8
    EC 2.9
  EC 3: Hydrolases
  EC 4: Lyases
  EC 5: Isomerases
  EC 6: Ligases
  General information:
  Catalytic mechanism
  Enzyme kinetics
  Inhibitors
  Enzymes in industry

EC 2.7.1.153 - ATP:1- phosphatidyl- 1D- myo- inositol- 4,5- bisphosphate 3- phosphotransferase (phosphatidylinositol- 4,5- bisphosphate 3- kinase)



3D structures of EC 2.7.1.153 - phosphatidylinositol-4,5-bisphosphate 3-kinase in Protein Data Bank

updated: 27 October 2021, 5:15

In total: 228 PDB structures of EC 2.7.1.153 - phosphatidylinositol-4,5-bisphosphate 3-kinase:
  1. 3oaw: 4-methylpteridineones as Orally Active and Selective PI3K/MTOR Dual Inhibitors
  2. 3ml9: Discovery of The Highly Potent PI3K/MTOR Dual Inhibitor Pf-04691502 through Structure Based Drug Design
  3. 3ml8: Discovery of The Highly Potent PI3K/MTOR Dual Inhibitor Pf-04691502 through Structure Based Drug Design
  4. 3mjw: Pi3 Kinase Gamma with a Benzofuranone Inhibitor
  5. 3lj3: Pi3-kinase-gamma with a Pyrrolopyridine-benzofuran Inhibitor
  6. 3l54: Structure of PI3K Gamma with Inhibitor
  7. 3l17: Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-pi3-kinase and Dual Pan-pi3-kinase/mtor Inhibitors for The Treatment of Cancer
  8. 3l16: Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-pi3-kinase and Dual Pan-pi3-kinase/mtor Inhibitors for The Treatment of Cancer
  9. 3l13: Crystal Structures of Pan-pi3-kinase and Dual Pan-pi3- Kinase/mtor Inhibitors
  10. 3l08: Structure of PI3K Gamma with a Potent Inhibitor: Gsk2126458
  11. 3ibe: Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to Pi3 Kinase Gamma
  12. 3hiz: Crystal Structure of P110ALPHA H1047R Mutant in Complex with Nish2 of P85ALPHA
  13. 3hhm: Crystal Structure of P110ALPHA H1047R Mutant in Complex with Nish2 of P85ALPHA and The Drug Wortmannin
  14. 3ene: Complex of PI3K Gamma with an Inhibitor
  15. 3dpd: Achieving Multi-isoform PI3K Inhibition in a Series of Substituted 3,4-dihydro-2h-benzo[1,4]oxazines
  16. 3dbs: Structure of PI3K Gamma in Complex with Gdc0941
  17. 3cst: Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2
  18. 3csf: Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor Dw2
  19. 2x6k: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with Pi-103
  20. 2x6j: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with Pik-93
  21. 2x6i: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with Pik-90
  22. 2x6h: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34
  23. 2x6f: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with 3-methyladenine
  24. 2x38: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Ic87114.
  25. 2wxr: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA.
  26. 2wxq: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with As15.
  27. 2wxp: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Gdc-0941.
  28. 2wxo: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with As5.
  29. 2wxn: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Dl07.
  30. 2wxm: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Dl06.
  31. 2wxl: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Zstk474.
  32. 2wxk: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Ink666.
  33. 2wxj: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Ink654.
  34. 2wxi: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Sw30.
  35. 2wxh: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Sw14.
  36. 2wxg: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Sw13.
  37. 2wxf: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Pik-39.
  38. 2a4z: Crystal Structure of Human PI3KGAMMA Complexed with As604850
  39. 2a5u: Crystal Structure of Human PI3KGAMMA Complexed with As605240
  40. 2v4l: Complex of Human Phosphoinositide 3-kinase Catalytic Subunit Gamma (p110 Gamma) with Pik-284
  41. 2v1y: Structure of a Phosphoinositide 3-kinase Alpha Adaptor- Binding Domain (abd) in a Complex with The Ish2 Domain from P85 Alpha
  42. 2rd0: Structure of a Human P110ALPHA/P85ALPHA Complex
  43. 2chw: A Pharmacological Map of The Pi3-k Family Defines a Role for P110 Alpha in Signaling: The Structure of Complex of Phosphoinositide 3-kinase Gamma with Inhibitor Pik-39
  44. 2chx: A Pharmacological Map of The Pi3-k Family Defines a Role for P110ALPHA in Signaling: The Structure of Complex of Phosphoinositide 3-kinase Gamma with Inhibitor Pik-90
  45. 2chz: A Pharmacological Map of The Pi3-k Family Defines a Role for P110ALPHA in Signaling: The Structure of Complex of Phosphoinositide 3-kinase Gamma with Inhibitor Pik-93
  46. 6zad: PI3K Delta in Complex with Methoxymethyloxathiatetraazatetracyclodocosahexaenedione
  47. 6zac: PI3K Delta in Complex with [(dimethylamino) METHYLDIHYDROBENZOXAZIN2METHOXYPYRIDINYL]METHANESULFONAMIDE
  48. 6zaa: PI3K Delta in Complex with Methoxy(methylsulfamoyl) Pyridinyln(methylpiperidinyl)dihydrobenzoxazinecarboxamide
  49. 6xrm: Crystal Structure of Human PI3K-GAMMA in Complex with Compound 4
  50. 6xrl: Crystal Structure of Human PI3K-GAMMA in Complex with Inhibitor Ipi- 549
  51. 6c1s: Phosphoinositide 3-kinase Gamma Bound to an Pyrrolopyridinone Inhibitor
  52. 6aud: PI3K-GAMMA K802T in Complex with Cpd 8 10-((1-(tert-butyl)piperidin-4- Yl)sulfinyl)-2-(1-isopropyl-1h-1,2,4-triazol-5-yl)-5,6- Dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine
  53. 2enq: Solution Structure of The C2 Domain from Human Pi3-kinase P110 Subunit Alpha
  54. 6g6w: Human PI3KDELTA in Complex with Ligand Lasw1976
  55. 6tns: PI3K Delta in Complex with 2methoxyn[2methoxy5(7{[(2r)4(oxetan3 Yl) MORPHOLIN2YL]METHOXY}1,3DIHYDRO2 BENZOFURAN5YL)PYRIDIN3YL]ETHANE1 Sulfonamide
  56. 6tnr: PI3K Delta in Complex with N[5(7{2[4(2HYDROXYPROPAN2YL)PIPERIDIN1 YL]ETHOXY}1,3DIHYDRO2BENZOFURAN5YL)2 METHOXYPYRIDIN3YL]METHANESULFONAMIDE
  57. 6t3c: Crystal Structure of PI3KGAMMA in Complex with Dna-pk Inhibitor Azd7648
  58. 6t3b: Crystal Structure of PI3KGAMMA with a Dihydropurinone Inhibitor (compound 4)
  59. 3nzs: Structure-based Optimization of Pyrazolo -pyrimidine and -pyridine Inhibitors of Pi3-kinase
  60. 3nzu: Structure-based Optimization of Pyrazolo -pyrimidine and -pyridine Inhibitors of Pi3-kinase
  61. 3pre: Quinazolines with Intra-molecular Hydrogen Bonding Scaffold (imhbs) as PI3K/MTOR Dual Inhibitors.
  62. 3prz: Quinazolines with Intra-molecular Hydrogen Bonding Scaffold (imhbs) as PI3K/MTOR Dual Inhibitors.
  63. 3ps6: Quinazolines with Intra-molecular Hydrogen Bonding Scaffold (imhbs) as PI3K/MTOR Dual Inhibitors.
  64. 3apc: Crystal Structure of Human PI3K-GAMMA in Complex with Ch5132799
  65. 3apd: Crystal Structure of Human PI3K-GAMMA in Complex with Ch5108134
  66. 3apf: Crystal Structure of Human PI3K-GAMMA in Complex with Ch5039699
  67. 3qaq: Crystal Structure of PI3K-GAMMA in Complex with Triazine-benzimidazole 1
  68. 3qar: Crystal Structure of PI3K-GAMMA in Complex with Triazine-benzimidazole 32
  69. 3qjz: Crystal Structure of PI3K-GAMMA in Complex with Benzothiazole 1
  70. 3qk0: Crystal Structure of PI3K-GAMMA in Complex with Benzothiazole 82
  71. 3s2a: Crystal Structure of PI3K-GAMMA in Complex with a Quinoline Inhibitor
  72. 3r7q: Structure-based Design of Thienobenzoxepin Inhibitors of Pi3- Kinase
  73. 3r7r: Structure-based Design of Thienobenzoxepin Inhibitors of Pi3-kinase
  74. 3p2b: Crystal Structure of PI3K Gamma with 3-(2-morpholino-6-(pyridin-3- Ylamino)pyrimidin-4-yl)phenol
  75. 6ocu: Human PI3KDELTA in Complex with Compound 29
  76. 6oco: Human PI3KDELTA in Complex with Compound 6
  77. 3zvv: Fragment Bound to PI3KINASE Gamma
  78. 3zw3: Fragment Based Discovery of a Novel and Selective Pi3 Kinase Inhibitor
  79. 3tl5: Discovery of Gdc-0980: a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-kinase (PI3K)/MAMMALIAN Target of Rapamycin (mtor) Kinase Inhibitor for The Treatment of Cancer
  80. 3t8m: Rational Design of PI3K-ALPHA Inhibitors That Exhibit Selectivity over The PI3K-BETA Isoform
  81. 4a55: Crystal Structure of P110ALPHA in Complex with Ish2 of P85ALPHA and The Inhibitor Pik-108
  82. 3sd5: Crystal Structure of PI3K Gamma with 5-(2,4-dimorpholinopyrimidin-6- Yl)-4-(trifluoromethyl)pyridin-2-amine
  83. 6q74: PI3K Delta in Complex with 1BENZYLN[5(3,6DIHYDRO2HPYRAN4YL) 2METHOXYPYRIDIN3YL]2METHYL1HIMIDAZOLE4SULFONAMIDE
  84. 6q73: PI3K Delta in Complex with N[2CHLORO5(3,6DIHYDRO2HPYRAN4YL) PYRIDIN3YL]METHANESULFONAMIDE
  85. 6q6y: PI3K Delta in Complex with N(2CHLORO5PHENYLPYRIDIN3YL) Benzenesulfonamide
  86. 6pyu: Human PI3KDELTA in Complex with Compound 4-2 ((3s)-1'- (cyclopropanecarbonyl)-5-(quinoxalin-6-yl)spiro[indole-3,2'- Pyrrolidin]-2(1h)-one)
  87. 6pys: Human PI3KALPHA in Complex with Compound 2-10 ((3s)-3-benzyl-3-methyl- 5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3- Dihydro-2h-indol-2-one)
  88. 6pyr: Human PI3KDELTA in Complex with Compound 2-10 ((3s)-3-benzyl-3-methyl- 5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3- Dihydro-2h-indol-2-one)
  89. 6oac: Pqr530 [(s)-4-(difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino- 1,3,5-triazin-2-yl)pyridin-2-amine] Bound to The PI3KA Catalytic Subunit P110ALPHA
  90. 4anu: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
  91. 4anv: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
  92. 4anw: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
  93. 4anx: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
  94. 4aof: Selective Small Molecule Inhibitor Discovered by Chemoproteomic Assay Platform Reveals Regulation of Th17 Cell Differentiation by PI3KGAMMA
  95. 4ajw: Discovery and Optimization of New Benzimidazole- and Benzoxazole- Pyrimidone Selective PI3KBETA Inhibitors for The Treatment of Phosphatase and Tensin Homologue (pten)-deficient Cancers
  96. 4dk5: Crystal Structure of Human PI3K-GAMMA in Complex with a Pyridyl- Triazine Inhibitor
  97. 6nct: Structure of P110ALPHA/NISH2 - Vector Data Collection
  98. 6mum: Murine PI3K Delta Kinsae Domain - Cpd 3
  99. 6mul: Murine PI3K Delta Kinsae Domain - Cpd 1
  100. 4fhj: Crystal Structure of PI3K-GAMMA in Complex with Imidazopyridine 2
  101. 4f1s: Crystal Structure of Human PI3K-GAMMA in Complex with a Pyridyl- Triazine-sulfonamide Inhibitor
  102. 4gb9: Potent and Highly Selective Benzimidazole Inhibitors of PI3K-DELTA
  103. 3tjp: Crystal Structure of PI3K Gamma with N6-(3,4-dimethoxyphenyl)-2- Morpholino-[4,5'-bipyrimidine]-2',6-diamine
  104. 4flh: Crystal Structure of Human PI3K-GAMMA in Complex with Amg511
  105. 4ful: Pi3 Kinase Gamma Bound to a Pyrmidine Inhibitor
  106. 4fjy: Crystal Structure of PI3K-GAMMA in Complex with Quinoline-indoline Inhibitor 24f
  107. 4fjz: Crystal Structure of PI3K-GAMMA in Complex with Pyrrolo-pyridine Inhibitor 63
  108. 4g11: X-ray Structure of PI3K-GAMMA Bound to a 4-(morpholin-4-yl)- (6-oxo-1, 6-dihydropyrimidin-2-yl)amide Inhibitor
  109. 3zim: Discovery of a Potent and Isoform-selective Targeted Covalent Inhibitor of The Lipid Kinase PI3KALPHA
  110. 4hle: Compound 21 (1-alkyl-substituted 1,2,4-triazoles)
  111. 6hi2: Pi3 Kinase Delta in Complex with 3{6[(1s,6r) 3OXABICYCLO[4.1.0]HEPTAN6YL]PYRIDIN2YL}PHENOL
  112. 6hi1: Pi3 Kinase Delta in Complex with 3[6(MORPHOLIN4YL)PYRIDIN2YL]PHENOL
  113. 4ezj: Potent and Selective Inhibitors of PI3K-DELTA: Obtaining Isoform Selectivity from The Affinity Pocket and Tryptophan Shelf
  114. 4ezk: Potent and Selective Inhibitors of PI3K-DELTA: Obtaining Isoform Selectivity from The Affinity Pocket and Tryptophan Shelf
  115. 4ezl: Potent and Selective Inhibitors of PI3K-DELTA: Obtaining Isoform Selectivity from The Affinity Pocket and Tryptophan Shelf
  116. 4fa6: Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3KA and Mtor
  117. 4fad: Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3KA and Mtor
  118. 6gy0: MPI3KD in Complex with Az3
  119. 4fhk: Crystal Structure of PI3K-GAMMA in Complex with Imidazopyridazine 19e
  120. 6gvi: Crystal Structure of PI3K Alpha in Complex with 3-(2-amino- Benzooxazol-5-yl)-1-isopropyl-1h-pyrazolo[3,4-d]pyrimidine-4,6- Diamine
  121. 6gvh: Crystal Structure of PI3K Alpha in Complex with 3-(2-amino- Benzooxazol-5-yl)-4-chloro-1-isopropyl-1h-pyrazolo[3,4-d]pyrimidin-6- Ylamine
  122. 6gvg: Crystal Structure of PI3K Alpha in Complex with 3-(2-amino- Benzooxazol-5-yl)-1-isopropyl-4-methyl-1h-pyrazolo[3,4-d]pyrimidin-6- Ylamine
  123. 6gvf: Crystal Structure of PI3K Alpha in Complex with 3-(2-amino- Benzooxazol-5-yl)-1-isopropyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine
  124. 6gq7: PI3KG in Complex with Inh
  125. 6fh5: PI3KG in Complex with Compound 7
  126. 6ez6: Pi3 Kinase Delta in Complex with Methyl 5-(4-(5-((4- Isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1h-indazol-6-yl)-2- Methoxynicotinate
  127. 4kz0: Structure of PI3K Gamma with Imidazopyridine Inhibitors
  128. 4kzc: Structure of PI3K Gamma with Imidazopyridine Inhibitors
  129. 6dgt: Selective PI3K Beta Inhibitor Bound to PI3K Delta
  130. 4bfr: Discovery and Optimization of Pyrimidone Indoline Amide PI3KBETA Inhibitors for The Treatment of Phosphatase and Tensin Homologue (pten)-deficient Cancers
  131. 4hvb: Catalytic Unit of PI3KG in Complex with PI3K/MTOR Dual Inhibitor Pf- 04979064
  132. 4j6i: Discovery of Thiazolobenzoxepin Pi3-kinase Inhibitors That Spare The Pi3-kinase Beta Isoform
  133. 4jps: Co-crystal Structures of The Lipid Kinase PI3K Alpha with Pan and Isoform Selective Inhibitors
  134. 4l1b: Crystal Structure of P110ALPHA Complexed with Nish2 of P85ALPHA
  135. 4l23: Crystal Structure of P110ALPHA Complexed with Nish2 of P85ALPHA and Pi-103
  136. 4l2y: Crystal Structure of P110ALPHA Complexed with Nish2 of P85ALPHA and Compound 9d
  137. 4ovu: Crystal Structure of P110ALPHA in Complex with Nish2 of P85ALPHA
  138. 4ovv: Crystal Structure of PI3KALPHA in Complex with Dic4-pip2
  139. 4ps3: Structure of PI3K Gamma in Complex with 1-[6-(5-methoxypyridin-3-yl)- 1,3-benzothiazol-2-yl]-3-[2-(1-propyl-1h-imidazol-4-yl)ethyl]urea
  140. 4ps7: Structure of PI3K Gamma in Complex with N-[6-(pyridin-3-yl)-1,3- Benzothiazol-2-yl]acetamide
  141. 4ps8: Structure of PI3K Gamma in Complex with N-[6-(5,6-dimethoxypyridin-3- Yl)-1,3-benzothiazol-2-yl]acetamide
  142. 5xgj: Crystal Structure of PI3K Complex with an Inhibitor
  143. 5xgi: Crystal Structure of PI3K Complex with an Inhibitor
  144. 5xgh: Crystal Structure of PI3K Complex with an Inhibitor
  145. 5vlr: Crystal Structure of PI3K Delta in Complex with a Trifluoro-ethyl- Pyrazol-pyrolotriazine Inhibitor
  146. 4tuu: Isolated P110A Subunit of PI3KA Provides a Platform for Structure- Based Drug Design
  147. 4tv3: Isolated P110A Subunit of PI3KA Provides a Platform for Structure- Based Drug Design
  148. 4urk: PI3KG in Complex with Azd6482
  149. 5ul1: The Co-structure of 3-amino-6-(4-((1-(dimethylamino)propan-2-yl) Sulfonyl)phenyl)-n-phenylpyrazine-2-carboxamide and a Rationally Designed PI3K-ALPHA Mutant That Mimics Atr
  150. 5ukj: The Co-structure of N,n-dimethyl-4-[(6r)-6-methyl-5-(1h-pyrrolo[2,3- B]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5- A]pyrazin-3- Yl]benzenesulfonamide and a Rationally Designed PI3K-ALPHA Mutant That Mimics Atr
  151. 5uk8: The Co-structure of (r)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2- (1h-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine and a Rationally Designed PI3K-ALPHA Mutant That Mimics Atr
  152. 5ubt: Crystal Structure of PI3K Delta in Complex with a 7-(3-(piperazin-1- Yl)phenyl)pyrrolo[2,1-f][1,2,4] Triazin-4-amine Deriviatine
  153. 5ubr: Crystal Structure of PI3K Alpha in Complex with a 7-(3-(piperazin-1- Yl)phenyl)pyrrolo[2,1-f][1,2,4] Triazin-4-amine Deriviatine
  154. 5t8i: PI3KDELTA in Complex with The Inhibitor Gs-9901
  155. 5t8f: P110DELTA/P85ALPHA with Taselisib (gdc-0032)
  156. 5t7f: PI3KDELTA in Complex with The Inhibitor Gs-643624
  157. 5t2m: MPI3KD in Complex with 7m
  158. 5t2l: MPI3KD in Complex with 7l
  159. 5t2i: MPI3KD in Complex with 7k
  160. 5t2g: MPI3KD in Complex with 7i
  161. 5t2d: MPI3KD in Complex with 7j
  162. 5t2b: MPI3KD in Complex with 5e
  163. 5t28: MPI3KD in Complex with 5k
  164. 5t27: MPI3KD in Complex with 5d
  165. 5t23: PI3KG in Complex with 5d
  166. 5sxk: Crystal Structure of PI3KALPHA in Complex with Fragment 18
  167. 5sxj: Crystal Structure of PI3KALPHA in Complex with Fragment 29
  168. 5sxi: Crystal Structure of PI3KALPHA in Complex with Fragment 13
  169. 5sxf: Crystal Structure of PI3KALPHA in Complex with Fragment 9
  170. 5sxe: Crystal Structure of PI3KALPHA in Complex with Fragments 19 and 28
  171. 5sxd: Crystal Structure of PI3KALPHA in Complex with Fragment 22
  172. 5sxc: Crystal Structure of PI3KALPHA in Complex with Fragment 8
  173. 5sxb: Crystal Structure of PI3KALPHA in Complex with Fragment 23
  174. 5sxa: Crystal Structure of PI3KALPHA in Complex with Fragment 10
  175. 5sx9: Crystal Structure of PI3KALPHA in Complex with Fragment 14
  176. 5sx8: Crystal Structure of PI3KALPHA in Complex with Fragments 12 and 15
  177. 5swt: Crystal Structure of PI3KALPHA in Complex with Fragments 17 and 27
  178. 5swr: Crystal Structure of PI3KALPHA in Complex with Fragments 20 and 26
  179. 5swp: Crystal Structure of PI3KALPHA in Complex with Fragments 6 and 24
  180. 5swo: Crystal Structure of PI3KALPHA in Complex with Fragments 4 and 19
  181. 5swg: Crystal Structure of PI3KALPHA in Complex with Fragments 5 and 21
  182. 5sw8: Crystal Structure of PI3KALPHA in Complex with Fragments 7 and 11
  183. 5oq4: Pqr309 - a Potent, Brain-penetrant, Orally Bioavailable, Pan-class I PI3K/MTOR Inhibitor as Clinical Candidate in Oncology
  184. 5o83: Discovery of Cdz173 (leniolisib), Representing a Structurally Novel Class of PI3K Delta-selective Inhibitors
  185. 5ncz: MPI3KD in Complex with Inh1
  186. 5ncy: MPI3KD in Complex with Inh1
  187. 5m6u: Human PI3KDELTA in Complex with Lasw1579
  188. 5kae: Crystal Structure of Human PI3K-GAMMA in Complex with Quinoline- Containing Inhibitor 5g
  189. 5jhb: Structure of Phosphoinositide 3-kinase Gamma (PI3K) Bound to The Potent Inhibitor Pikin3
  190. 5jha: Structure of Phosphoinositide 3-kinase Gamma (PI3K) Bound to The Potent Inhibitor Pikin2
  191. 5itd: Crystal Structure of PI3K Alpha with PI3K Delta Inhibitor
  192. 5is5: Discovery and Pharmacological Characterization of Novel Quinazoline- Based PI3K Delta-selective Inhibitors
  193. 5i6u: The Crystal Structure of PI3KDELTA with Compound 32
  194. 5i4u: The Crystal Structure of PI3KDELTA with Compound 34
  195. 5g55: 3-quinoline Carboxamides Inhibitors of PI3K
  196. 5g2n: X-ray Structure of PI3KINASE Gamma in Complex with Copanlisib
  197. 5fi4: Discovery of Imidazo[1,2-a]-pyridine Inhibitors of Pan-pi3 Kinases That Are Efficacious in a Mouse Xenograft Model
  198. 5eds: Crystal Structure of Human PI3K-GAMMA in Complex with Benzimidazole Inhibitor 5
  199. 5dxu: P110DELTA/P85ALPHA with Gdc-0326
  200. 5dxt: P110ALPHA with Gdc-0326
  201. 5dxh: P110ALPHA/P85ALPHA with Compound 5
  202. 4wwn: Crystal Structure of Human PI3K-GAMMA in Complex with (s)-n-(1-(7- Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9h-purin-6-amine Amg319 Inhibitor
  203. 4wwo: Crystal Structure of Human PI3K-GAMMA in Complex with Phenylquinoline Inhibitor N-{(1s)-1-[8-chloro-2-(3-fluorophenyl)quinolin-3-yl]ethyl}- 9h-purin-6-amine
  204. 4wwp: Crystal Structure of Human PI3K-GAMMA in Complex with Pyridinylquinoline Inhibitor N-{(1s)-1-[8-chloro-2-(2-methylpyridin- 3-yl)quinolin-3-yl]ethyl}-9h-purin-6-amine
  205. 4waf: Crystal Structure of a Novel Tetrahydropyrazolo[1,5-a]pyrazine in an Engineered PI3K Alpha
  206. 4xe0: Idelalisib Bound to The P110 Subunit of PI3K Delta
  207. 4zop: Co-crystal Structure of Lipid Kinase PI3K Alpha with a Selective Phosphatidylinositol-3 Kinase Alpha Inhibitor
  208. 4ykn: PI3K Alpha Lipid Kinase with Active Site Inhibitor
  209. 4v0i: Water Network Determines Selectivity for a Series of Pyrimidone Indoline Amide PI3KBETA Inhibitors over PI3K-DELTA
  210. 4xx5: Structure of PI3K Gamma in Complex with an Inhibitor
  211. 4xz4: Structure of PI3K Gamma in Complex with an Inhibitor
  212. 7jis: Human PI3KDELTA in Complex with Compound 2f
  213. 7k6m: Crystal Structure of PI3KALPHA Selective Inhibitor Pf-06843195
  214. 7k6n: Crystal Structure of PI3KALPHA Selective Inhibitor 11-1575
  215. 7k6o: Crystal Structure of PI3KALPHA Inhibitor 10-5429
  216. 7k71: Crystal Structure of PI3KALPHA Inhibitor 4-0686
  217. 6vo7: Crystal Structure of PI3K-ALPHA Ras Binding Domain (rbd)
  218. 7jwe: Gedatolisib Bound to The PI3KG Catalytic Subunit P110 Gamma
  219. 7jwz: Ipi-549 Bound to The PI3KG Catalytic Subunit P110 Gamma
  220. 7jx0: Nvs-pi3-4 Bound to The PI3KG Catalytic Subunit P110 Gamma
  221. 7kke: Phosphoinositide 3-kinase Gamma Bound to a Thiazole Inhibitor
  222. 7lm2: Human PI3KDELTA in Complex with Compound 3c
  223. 7jiu: Human PI3KDELTA in Complex with Compound 2f
  224. 7mez: Structure of The Phosphoinositide 3-kinase P110 Gamma (PIK3CG) P101 (PIK3R5) Complex
  225. 7pop: Pi3 Kinase Delta in Complex with 5-[3,6-dihydro-2h-pyran-4-yl]-2- Methoxy-n-[2-methylpyridin-4-yl]pyridine-3-sulfonamide
  226. 7por: Pi3 Kinase Delta in Complex with N-[2-(2-fluoro-4-{[4-(propan-2-yl) Piperazin-1-yl]methyl}phenyl)pyridin-4-yl]-2-methoxy-5-(morpholin-4- Yl)pyridine-3-sulfonamide
  227. 7pos: Pi3 Kinase Delta in Complex with 5-(3,6-dihydro-2h-pyran-4-yl)-2- Methoxy-n-(5-{3-[4-(propan-2-yl)piperazin-1-yl]prop-1-yn-1- Yl}pyridin-3-yl)pyridine-3-sulfonamide
  228. 7pot: Pi3 Kinase Delta in Complex with N-[5-(3,6-dihydro-2h-pyran-4-yl)-2- Methoxypyridin-3-yl]benzenesulfonamide
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