EC 2.7.1.153 - ATP:1- phosphatidyl- 1D- myo- inositol- 4,5- bisphosphate 3- phosphotransferase (phosphatidylinositol- 4,5- bisphosphate 3- kinase)

3D structures of EC 2.7.1.153 - phosphatidylinositol-4,5-bisphosphate 3-kinase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 3oaw: 4-methylpteridineones as Orally Active and Selective PI3K/MTOR Dual Inhibitors
2. 3ml9: Discovery of The Highly Potent PI3K/MTOR Dual Inhibitor Pf-04691502 through Structure Based Drug Design
3. 3ml8: Discovery of The Highly Potent PI3K/MTOR Dual Inhibitor Pf-04691502 through Structure Based Drug Design
4. 3mjw: Pi3 Kinase Gamma with a Benzofuranone Inhibitor
5. 3lj3: Pi3-kinase-gamma with a Pyrrolopyridine-benzofuran Inhibitor
6. 3l54: Structure of PI3K Gamma with Inhibitor
7. 3l17: Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-pi3-kinase and Dual Pan-pi3-kinase/mtor Inhibitors for The Treatment of Cancer
8. 3l16: Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-pi3-kinase and Dual Pan-pi3-kinase/mtor Inhibitors for The Treatment of Cancer
9. 3l13: Crystal Structures of Pan-pi3-kinase and Dual Pan-pi3- Kinase/mtor Inhibitors
10. 3l08: Structure of PI3K Gamma with a Potent Inhibitor: Gsk2126458
11. 3ibe: Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to Pi3 Kinase Gamma
12. 3hiz: Crystal Structure of P110ALPHA H1047R Mutant in Complex with Nish2 of P85ALPHA
13. 3hhm: Crystal Structure of P110ALPHA H1047R Mutant in Complex with Nish2 of P85ALPHA and The Drug Wortmannin
14. 3ene: Complex of PI3K Gamma with an Inhibitor
15. 3dpd: Achieving Multi-isoform PI3K Inhibition in a Series of Substituted 3,4-dihydro-2h-benzo[1,4]oxazines
16. 3dbs: Structure of PI3K Gamma in Complex with Gdc0941
17. 3cst: Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2
18. 3csf: Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor Dw2
19. 2x6k: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with Pi-103
20. 2x6j: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with Pik-93
21. 2x6i: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with Pik-90
22. 2x6h: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34
23. 2x6f: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with 3-methyladenine
24. 2x38: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Ic87114.
25. 2wxr: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA.
26. 2wxq: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with As15.
27. 2wxp: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Gdc-0941.
28. 2wxo: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with As5.
29. 2wxn: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Dl07.
30. 2wxm: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Dl06.
31. 2wxl: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Zstk474.
32. 2wxk: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Ink666.
33. 2wxj: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Ink654.
34. 2wxi: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Sw30.
35. 2wxh: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Sw14.
36. 2wxg: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Sw13.
37. 2wxf: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Pik-39.
38. 2a4z: Crystal Structure of Human PI3KGAMMA Complexed with As604850
39. 2a5u: Crystal Structure of Human PI3KGAMMA Complexed with As605240
40. 2v4l: Complex of Human Phosphoinositide 3-kinase Catalytic Subunit Gamma (p110 Gamma) with Pik-284
41. 2v1y: Structure of a Phosphoinositide 3-kinase Alpha Adaptor- Binding Domain (abd) in a Complex with The Ish2 Domain from P85 Alpha
42. 2rd0: Structure of a Human P110ALPHA/P85ALPHA Complex
43. 2chw: A Pharmacological Map of The Pi3-k Family Defines a Role for P110 Alpha in Signaling: The Structure of Complex of Phosphoinositide 3-kinase Gamma with Inhibitor Pik-39
44. 2chx: A Pharmacological Map of The Pi3-k Family Defines a Role for P110ALPHA in Signaling: The Structure of Complex of Phosphoinositide 3-kinase Gamma with Inhibitor Pik-90
45. 2chz: A Pharmacological Map of The Pi3-k Family Defines a Role for P110ALPHA in Signaling: The Structure of Complex of Phosphoinositide 3-kinase Gamma with Inhibitor Pik-93
46. 6zad: PI3K Delta in Complex with Methoxymethyloxathiatetraazatetracyclodocosahexaenedione
47. 6zac: PI3K Delta in Complex with [(dimethylamino) METHYLDIHYDROBENZOXAZIN2METHOXYPYRIDINYL]METHANESULFONAMIDE
48. 6zaa: PI3K Delta in Complex with Methoxy(methylsulfamoyl) Pyridinyln(methylpiperidinyl)dihydrobenzoxazinecarboxamide
49. 6xrm: Crystal Structure of Human PI3K-GAMMA in Complex with Compound 4
50. 6xrl: Crystal Structure of Human PI3K-GAMMA in Complex with Inhibitor Ipi- 549
51. 6c1s: Phosphoinositide 3-kinase Gamma Bound to an Pyrrolopyridinone Inhibitor
52. 6aud: PI3K-GAMMA K802T in Complex with Cpd 8 10-((1-(tert-butyl)piperidin-4- Yl)sulfinyl)-2-(1-isopropyl-1h-1,2,4-triazol-5-yl)-5,6- Dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine
53. 2enq: Solution Structure of The C2 Domain from Human Pi3-kinase P110 Subunit Alpha
54. 6g6w: Human PI3KDELTA in Complex with Ligand Lasw1976
55. 6tns: PI3K Delta in Complex with 2methoxyn[2methoxy5(7{[(2r)4(oxetan3 Yl) MORPHOLIN2YL]METHOXY}1,3DIHYDRO2 BENZOFURAN5YL)PYRIDIN3YL]ETHANE1 Sulfonamide
56. 6tnr: PI3K Delta in Complex with N[5(7{2[4(2HYDROXYPROPAN2YL)PIPERIDIN1 YL]ETHOXY}1,3DIHYDRO2BENZOFURAN5YL)2 METHOXYPYRIDIN3YL]METHANESULFONAMIDE
57. 6t3c: Crystal Structure of PI3KGAMMA in Complex with Dna-pk Inhibitor Azd7648
58. 6t3b: Crystal Structure of PI3KGAMMA with a Dihydropurinone Inhibitor (compound 4)
59. 3nzs: Structure-based Optimization of Pyrazolo -pyrimidine and -pyridine Inhibitors of Pi3-kinase
60. 3nzu: Structure-based Optimization of Pyrazolo -pyrimidine and -pyridine Inhibitors of Pi3-kinase
61. 3pre: Quinazolines with Intra-molecular Hydrogen Bonding Scaffold (imhbs) as PI3K/MTOR Dual Inhibitors.
62. 3prz: Quinazolines with Intra-molecular Hydrogen Bonding Scaffold (imhbs) as PI3K/MTOR Dual Inhibitors.
63. 3ps6: Quinazolines with Intra-molecular Hydrogen Bonding Scaffold (imhbs) as PI3K/MTOR Dual Inhibitors.
64. 3apc: Crystal Structure of Human PI3K-GAMMA in Complex with Ch5132799
65. 3apd: Crystal Structure of Human PI3K-GAMMA in Complex with Ch5108134
66. 3apf: Crystal Structure of Human PI3K-GAMMA in Complex with Ch5039699
67. 3qaq: Crystal Structure of PI3K-GAMMA in Complex with Triazine-benzimidazole 1
68. 3qar: Crystal Structure of PI3K-GAMMA in Complex with Triazine-benzimidazole 32
69. 3qjz: Crystal Structure of PI3K-GAMMA in Complex with Benzothiazole 1
70. 3qk0: Crystal Structure of PI3K-GAMMA in Complex with Benzothiazole 82
71. 3s2a: Crystal Structure of PI3K-GAMMA in Complex with a Quinoline Inhibitor
72. 3r7q: Structure-based Design of Thienobenzoxepin Inhibitors of Pi3- Kinase
73. 3r7r: Structure-based Design of Thienobenzoxepin Inhibitors of Pi3-kinase
74. 3p2b: Crystal Structure of PI3K Gamma with 3-(2-morpholino-6-(pyridin-3- Ylamino)pyrimidin-4-yl)phenol
75. 6ocu: Human PI3KDELTA in Complex with Compound 29
76. 6oco: Human PI3KDELTA in Complex with Compound 6
77. 3zvv: Fragment Bound to PI3KINASE Gamma
78. 3zw3: Fragment Based Discovery of a Novel and Selective Pi3 Kinase Inhibitor
79. 3tl5: Discovery of Gdc-0980: a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-kinase (PI3K)/MAMMALIAN Target of Rapamycin (mtor) Kinase Inhibitor for The Treatment of Cancer
80. 3t8m: Rational Design of PI3K-ALPHA Inhibitors That Exhibit Selectivity over The PI3K-BETA Isoform
81. 4a55: Crystal Structure of P110ALPHA in Complex with Ish2 of P85ALPHA and The Inhibitor Pik-108
82. 3sd5: Crystal Structure of PI3K Gamma with 5-(2,4-dimorpholinopyrimidin-6- Yl)-4-(trifluoromethyl)pyridin-2-amine
83. 6q74: PI3K Delta in Complex with 1BENZYLN[5(3,6DIHYDRO2HPYRAN4YL) 2METHOXYPYRIDIN3YL]2METHYL1HIMIDAZOLE4SULFONAMIDE
84. 6q73: PI3K Delta in Complex with N[2CHLORO5(3,6DIHYDRO2HPYRAN4YL) PYRIDIN3YL]METHANESULFONAMIDE
85. 6q6y: PI3K Delta in Complex with N(2CHLORO5PHENYLPYRIDIN3YL) Benzenesulfonamide
86. 6pyu: Human PI3KDELTA in Complex with Compound 4-2 ((3s)-1'- (cyclopropanecarbonyl)-5-(quinoxalin-6-yl)spiro[indole-3,2'- Pyrrolidin]-2(1h)-one)
87. 6pys: Human PI3KALPHA in Complex with Compound 2-10 ((3s)-3-benzyl-3-methyl- 5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3- Dihydro-2h-indol-2-one)
88. 6pyr: Human PI3KDELTA in Complex with Compound 2-10 ((3s)-3-benzyl-3-methyl- 5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3- Dihydro-2h-indol-2-one)
89. 6oac: Pqr530 [(s)-4-(difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino- 1,3,5-triazin-2-yl)pyridin-2-amine] Bound to The PI3KA Catalytic Subunit P110ALPHA
90. 4anu: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
91. 4anv: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
92. 4anw: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
93. 4anx: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
94. 4aof: Selective Small Molecule Inhibitor Discovered by Chemoproteomic Assay Platform Reveals Regulation of Th17 Cell Differentiation by PI3KGAMMA
95. 4ajw: Discovery and Optimization of New Benzimidazole- and Benzoxazole- Pyrimidone Selective PI3KBETA Inhibitors for The Treatment of Phosphatase and Tensin Homologue (pten)-deficient Cancers
96. 4dk5: Crystal Structure of Human PI3K-GAMMA in Complex with a Pyridyl- Triazine Inhibitor
97. 6nct: Structure of P110ALPHA/NISH2 - Vector Data Collection
98. 6mum: Murine PI3K Delta Kinsae Domain - Cpd 3
99. 6mul: Murine PI3K Delta Kinsae Domain - Cpd 1
100. 4fhj: Crystal Structure of PI3K-GAMMA in Complex with Imidazopyridine 2
101. 4f1s: Crystal Structure of Human PI3K-GAMMA in Complex with a Pyridyl- Triazine-sulfonamide Inhibitor
102. 4gb9: Potent and Highly Selective Benzimidazole Inhibitors of PI3K-DELTA
103. 3tjp: Crystal Structure of PI3K Gamma with N6-(3,4-dimethoxyphenyl)-2- Morpholino-[4,5'-bipyrimidine]-2',6-diamine
104. 4flh: Crystal Structure of Human PI3K-GAMMA in Complex with Amg511
105. 4ful: Pi3 Kinase Gamma Bound to a Pyrmidine Inhibitor
106. 4fjy: Crystal Structure of PI3K-GAMMA in Complex with Quinoline-indoline Inhibitor 24f
107. 4fjz: Crystal Structure of PI3K-GAMMA in Complex with Pyrrolo-pyridine Inhibitor 63
108. 4g11: X-ray Structure of PI3K-GAMMA Bound to a 4-(morpholin-4-yl)- (6-oxo-1, 6-dihydropyrimidin-2-yl)amide Inhibitor
109. 3zim: Discovery of a Potent and Isoform-selective Targeted Covalent Inhibitor of The Lipid Kinase PI3KALPHA
110. 4hle: Compound 21 (1-alkyl-substituted 1,2,4-triazoles)
111. 6hi2: Pi3 Kinase Delta in Complex with 3{6[(1s,6r) 3OXABICYCLO[4.1.0]HEPTAN6YL]PYRIDIN2YL}PHENOL
112. 6hi1: Pi3 Kinase Delta in Complex with 3[6(MORPHOLIN4YL)PYRIDIN2YL]PHENOL
113. 4ezj: Potent and Selective Inhibitors of PI3K-DELTA: Obtaining Isoform Selectivity from The Affinity Pocket and Tryptophan Shelf
114. 4ezk: Potent and Selective Inhibitors of PI3K-DELTA: Obtaining Isoform Selectivity from The Affinity Pocket and Tryptophan Shelf
115. 4ezl: Potent and Selective Inhibitors of PI3K-DELTA: Obtaining Isoform Selectivity from The Affinity Pocket and Tryptophan Shelf
116. 4fa6: Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3KA and Mtor
117. 4fad: Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3KA and Mtor
118. 6gy0: MPI3KD in Complex with Az3
119. 4fhk: Crystal Structure of PI3K-GAMMA in Complex with Imidazopyridazine 19e
120. 6gvi: Crystal Structure of PI3K Alpha in Complex with 3-(2-amino- Benzooxazol-5-yl)-1-isopropyl-1h-pyrazolo[3,4-d]pyrimidine-4,6- Diamine
121. 6gvh: Crystal Structure of PI3K Alpha in Complex with 3-(2-amino- Benzooxazol-5-yl)-4-chloro-1-isopropyl-1h-pyrazolo[3,4-d]pyrimidin-6- Ylamine
122. 6gvg: Crystal Structure of PI3K Alpha in Complex with 3-(2-amino- Benzooxazol-5-yl)-1-isopropyl-4-methyl-1h-pyrazolo[3,4-d]pyrimidin-6- Ylamine
123. 6gvf: Crystal Structure of PI3K Alpha in Complex with 3-(2-amino- Benzooxazol-5-yl)-1-isopropyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine
124. 6gq7: PI3KG in Complex with Inh
125. 6fh5: PI3KG in Complex with Compound 7
126. 6ez6: Pi3 Kinase Delta in Complex with Methyl 5-(4-(5-((4- Isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1h-indazol-6-yl)-2- Methoxynicotinate
127. 4kz0: Structure of PI3K Gamma with Imidazopyridine Inhibitors
128. 4kzc: Structure of PI3K Gamma with Imidazopyridine Inhibitors
129. 6dgt: Selective PI3K Beta Inhibitor Bound to PI3K Delta
130. 4bfr: Discovery and Optimization of Pyrimidone Indoline Amide PI3KBETA Inhibitors for The Treatment of Phosphatase and Tensin Homologue (pten)-deficient Cancers
131. 4hvb: Catalytic Unit of PI3KG in Complex with PI3K/MTOR Dual Inhibitor Pf- 04979064
132. 4j6i: Discovery of Thiazolobenzoxepin Pi3-kinase Inhibitors That Spare The Pi3-kinase Beta Isoform
133. 4jps: Co-crystal Structures of The Lipid Kinase PI3K Alpha with Pan and Isoform Selective Inhibitors
134. 4l1b: Crystal Structure of P110ALPHA Complexed with Nish2 of P85ALPHA
135. 4l23: Crystal Structure of P110ALPHA Complexed with Nish2 of P85ALPHA and Pi-103
136. 4l2y: Crystal Structure of P110ALPHA Complexed with Nish2 of P85ALPHA and Compound 9d
137. 4ovu: Crystal Structure of P110ALPHA in Complex with Nish2 of P85ALPHA
138. 4ovv: Crystal Structure of PI3KALPHA in Complex with Dic4-pip2
139. 4ps3: Structure of PI3K Gamma in Complex with 1-[6-(5-methoxypyridin-3-yl)- 1,3-benzothiazol-2-yl]-3-[2-(1-propyl-1h-imidazol-4-yl)ethyl]urea
140. 4ps7: Structure of PI3K Gamma in Complex with N-[6-(pyridin-3-yl)-1,3- Benzothiazol-2-yl]acetamide
141. 4ps8: Structure of PI3K Gamma in Complex with N-[6-(5,6-dimethoxypyridin-3- Yl)-1,3-benzothiazol-2-yl]acetamide
142. 5xgj: Crystal Structure of PI3K Complex with an Inhibitor
143. 5xgi: Crystal Structure of PI3K Complex with an Inhibitor
144. 5xgh: Crystal Structure of PI3K Complex with an Inhibitor
145. 5vlr: Crystal Structure of PI3K Delta in Complex with a Trifluoro-ethyl- Pyrazol-pyrolotriazine Inhibitor
146. 4tuu: Isolated P110A Subunit of PI3KA Provides a Platform for Structure- Based Drug Design
147. 4tv3: Isolated P110A Subunit of PI3KA Provides a Platform for Structure- Based Drug Design
148. 4urk: PI3KG in Complex with Azd6482
149. 5ul1: The Co-structure of 3-amino-6-(4-((1-(dimethylamino)propan-2-yl) Sulfonyl)phenyl)-n-phenylpyrazine-2-carboxamide and a Rationally Designed PI3K-ALPHA Mutant That Mimics Atr
150. 5ukj: The Co-structure of N,n-dimethyl-4-[(6r)-6-methyl-5-(1h-pyrrolo[2,3- B]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5- A]pyrazin-3- Yl]benzenesulfonamide and a Rationally Designed PI3K-ALPHA Mutant That Mimics Atr
151. 5uk8: The Co-structure of (r)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2- (1h-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine and a Rationally Designed PI3K-ALPHA Mutant That Mimics Atr
152. 5ubt: Crystal Structure of PI3K Delta in Complex with a 7-(3-(piperazin-1- Yl)phenyl)pyrrolo[2,1-f][1,2,4] Triazin-4-amine Deriviatine
153. 5ubr: Crystal Structure of PI3K Alpha in Complex with a 7-(3-(piperazin-1- Yl)phenyl)pyrrolo[2,1-f][1,2,4] Triazin-4-amine Deriviatine
154. 5t8i: PI3KDELTA in Complex with The Inhibitor Gs-9901
155. 5t8f: P110DELTA/P85ALPHA with Taselisib (gdc-0032)
156. 5t7f: PI3KDELTA in Complex with The Inhibitor Gs-643624
157. 5t2m: MPI3KD in Complex with 7m
158. 5t2l: MPI3KD in Complex with 7l
159. 5t2i: MPI3KD in Complex with 7k
160. 5t2g: MPI3KD in Complex with 7i
161. 5t2d: MPI3KD in Complex with 7j
162. 5t2b: MPI3KD in Complex with 5e
163. 5t28: MPI3KD in Complex with 5k
164. 5t27: MPI3KD in Complex with 5d
165. 5t23: PI3KG in Complex with 5d
166. 5sxk: Crystal Structure of PI3KALPHA in Complex with Fragment 18
167. 5sxj: Crystal Structure of PI3KALPHA in Complex with Fragment 29
168. 5sxi: Crystal Structure of PI3KALPHA in Complex with Fragment 13
169. 5sxf: Crystal Structure of PI3KALPHA in Complex with Fragment 9
170. 5sxe: Crystal Structure of PI3KALPHA in Complex with Fragments 19 and 28
171. 5sxd: Crystal Structure of PI3KALPHA in Complex with Fragment 22
172. 5sxc: Crystal Structure of PI3KALPHA in Complex with Fragment 8
173. 5sxb: Crystal Structure of PI3KALPHA in Complex with Fragment 23
174. 5sxa: Crystal Structure of PI3KALPHA in Complex with Fragment 10
175. 5sx9: Crystal Structure of PI3KALPHA in Complex with Fragment 14
176. 5sx8: Crystal Structure of PI3KALPHA in Complex with Fragments 12 and 15
177. 5swt: Crystal Structure of PI3KALPHA in Complex with Fragments 17 and 27
178. 5swr: Crystal Structure of PI3KALPHA in Complex with Fragments 20 and 26
179. 5swp: Crystal Structure of PI3KALPHA in Complex with Fragments 6 and 24
180. 5swo: Crystal Structure of PI3KALPHA in Complex with Fragments 4 and 19
181. 5swg: Crystal Structure of PI3KALPHA in Complex with Fragments 5 and 21
182. 5sw8: Crystal Structure of PI3KALPHA in Complex with Fragments 7 and 11
183. 5oq4: Pqr309 - a Potent, Brain-penetrant, Orally Bioavailable, Pan-class I PI3K/MTOR Inhibitor as Clinical Candidate in Oncology
184. 5o83: Discovery of Cdz173 (leniolisib), Representing a Structurally Novel Class of PI3K Delta-selective Inhibitors
185. 5ncz: MPI3KD in Complex with Inh1
186. 5ncy: MPI3KD in Complex with Inh1
187. 5m6u: Human PI3KDELTA in Complex with Lasw1579
188. 5kae: Crystal Structure of Human PI3K-GAMMA in Complex with Quinoline- Containing Inhibitor 5g
189. 5jhb: Structure of Phosphoinositide 3-kinase Gamma (PI3K) Bound to The Potent Inhibitor Pikin3
190. 5jha: Structure of Phosphoinositide 3-kinase Gamma (PI3K) Bound to The Potent Inhibitor Pikin2
191. 5itd: Crystal Structure of PI3K Alpha with PI3K Delta Inhibitor
192. 5is5: Discovery and Pharmacological Characterization of Novel Quinazoline- Based PI3K Delta-selective Inhibitors
193. 5i6u: The Crystal Structure of PI3KDELTA with Compound 32
194. 5i4u: The Crystal Structure of PI3KDELTA with Compound 34
195. 5g55: 3-quinoline Carboxamides Inhibitors of PI3K
196. 5g2n: X-ray Structure of PI3KINASE Gamma in Complex with Copanlisib
197. 5fi4: Discovery of Imidazo[1,2-a]-pyridine Inhibitors of Pan-pi3 Kinases That Are Efficacious in a Mouse Xenograft Model
198. 5eds: Crystal Structure of Human PI3K-GAMMA in Complex with Benzimidazole Inhibitor 5
199. 5dxu: P110DELTA/P85ALPHA with Gdc-0326
200. 5dxt: P110ALPHA with Gdc-0326
201. 5dxh: P110ALPHA/P85ALPHA with Compound 5
202. 4wwn: Crystal Structure of Human PI3K-GAMMA in Complex with (s)-n-(1-(7- Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9h-purin-6-amine Amg319 Inhibitor
203. 4wwo: Crystal Structure of Human PI3K-GAMMA in Complex with Phenylquinoline Inhibitor N-{(1s)-1-[8-chloro-2-(3-fluorophenyl)quinolin-3-yl]ethyl}- 9h-purin-6-amine
204. 4wwp: Crystal Structure of Human PI3K-GAMMA in Complex with Pyridinylquinoline Inhibitor N-{(1s)-1-[8-chloro-2-(2-methylpyridin- 3-yl)quinolin-3-yl]ethyl}-9h-purin-6-amine
205. 4waf: Crystal Structure of a Novel Tetrahydropyrazolo[1,5-a]pyrazine in an Engineered PI3K Alpha
206. 4xe0: Idelalisib Bound to The P110 Subunit of PI3K Delta
207. 4zop: Co-crystal Structure of Lipid Kinase PI3K Alpha with a Selective Phosphatidylinositol-3 Kinase Alpha Inhibitor
208. 4ykn: PI3K Alpha Lipid Kinase with Active Site Inhibitor
209. 4v0i: Water Network Determines Selectivity for a Series of Pyrimidone Indoline Amide PI3KBETA Inhibitors over PI3K-DELTA
210. 4xx5: Structure of PI3K Gamma in Complex with an Inhibitor
211. 4xz4: Structure of PI3K Gamma in Complex with an Inhibitor
212. 7jis: Human PI3KDELTA in Complex with Compound 2f
213. 7k6m: Crystal Structure of PI3KALPHA Selective Inhibitor Pf-06843195
214. 7k6n: Crystal Structure of PI3KALPHA Selective Inhibitor 11-1575
215. 7k6o: Crystal Structure of PI3KALPHA Inhibitor 10-5429
216. 7k71: Crystal Structure of PI3KALPHA Inhibitor 4-0686
217. 6vo7: Crystal Structure of PI3K-ALPHA Ras Binding Domain (rbd)
218. 7jwe: Gedatolisib Bound to The PI3KG Catalytic Subunit P110 Gamma
219. 7jwz: Ipi-549 Bound to The PI3KG Catalytic Subunit P110 Gamma
220. 7jx0: Nvs-pi3-4 Bound to The PI3KG Catalytic Subunit P110 Gamma
221. 7kke: Phosphoinositide 3-kinase Gamma Bound to a Thiazole Inhibitor
222. 7lm2: Human PI3KDELTA in Complex with Compound 3c
223. 7jiu: Human PI3KDELTA in Complex with Compound 2f
224. 7mez: Structure of The Phosphoinositide 3-kinase P110 Gamma (PIK3CG) P101 (PIK3R5) Complex
225. 7pop: Pi3 Kinase Delta in Complex with 5-[3,6-dihydro-2h-pyran-4-yl]-2- Methoxy-n-[2-methylpyridin-4-yl]pyridine-3-sulfonamide
226. 7por: Pi3 Kinase Delta in Complex with N-[2-(2-fluoro-4-{[4-(propan-2-yl) Piperazin-1-yl]methyl}phenyl)pyridin-4-yl]-2-methoxy-5-(morpholin-4- Yl)pyridine-3-sulfonamide
227. 7pos: Pi3 Kinase Delta in Complex with 5-(3,6-dihydro-2h-pyran-4-yl)-2- Methoxy-n-(5-{3-[4-(propan-2-yl)piperazin-1-yl]prop-1-yn-1- Yl}pyridin-3-yl)pyridine-3-sulfonamide
228. 7pot: Pi3 Kinase Delta in Complex with N-[5-(3,6-dihydro-2h-pyran-4-yl)-2- Methoxypyridin-3-yl]benzenesulfonamide
229. 6xrn: Crystal Structure of Human PI3K-GAMMA in Complex with Compound 17
230. 7myn: Cryo-em Structure of P110ALPHA in Complex with P85ALPHA
231. 7myo: Cryo-em Structure of P110ALPHA in Complex with P85ALPHA Inhibited by Byl-719