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enzyme (lysozyme)

 
Enzymes
  Enzyme classes:
  EC 1: Oxidoreductases
  EC 2: Transferases
    EC 2.1
    EC 2.2
    EC 2.3
    EC 2.4
    EC 2.5
    EC 2.6
    EC 2.7
      EC 2.7.1
        EC 2.7.1.1
        EC 2.7.1.2
        EC 2.7.1.3
        EC 2.7.1.4
        EC 2.7.1.5
        EC 2.7.1.6
        EC 2.7.1.7
        EC 2.7.1.8
        EC 2.7.1.9
        EC 2.7.1.10
        EC 2.7.1.11
        EC 2.7.1.12
        EC 2.7.1.13
        EC 2.7.1.14
        EC 2.7.1.15
        EC 2.7.1.16
        EC 2.7.1.17
        EC 2.7.1.18
        EC 2.7.1.19
        EC 2.7.1.20
        EC 2.7.1.21
        EC 2.7.1.22
        EC 2.7.1.23
        EC 2.7.1.24
        EC 2.7.1.25
        EC 2.7.1.26
        EC 2.7.1.27
        EC 2.7.1.28
        EC 2.7.1.29
        EC 2.7.1.30
        EC 2.7.1.31
        EC 2.7.1.32
        EC 2.7.1.33
        EC 2.7.1.34
        EC 2.7.1.35
        EC 2.7.1.36
        EC 2.7.1.37
        EC 2.7.1.38
        EC 2.7.1.39
        EC 2.7.1.40
        EC 2.7.1.41
        EC 2.7.1.42
        EC 2.7.1.43
        EC 2.7.1.44
        EC 2.7.1.45
        EC 2.7.1.46
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        EC 2.7.1.50
        EC 2.7.1.51
        EC 2.7.1.52
        EC 2.7.1.53
        EC 2.7.1.54
        EC 2.7.1.55
        EC 2.7.1.56
        EC 2.7.1.57
        EC 2.7.1.58
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        EC 2.7.1.60
        EC 2.7.1.61
        EC 2.7.1.62
        EC 2.7.1.63
        EC 2.7.1.64
        EC 2.7.1.65
        EC 2.7.1.66
        EC 2.7.1.67
        EC 2.7.1.68
        EC 2.7.1.69
        EC 2.7.1.70
        EC 2.7.1.71
        EC 2.7.1.72
        EC 2.7.1.73
        EC 2.7.1.74
        EC 2.7.1.75
        EC 2.7.1.76
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        EC 2.7.1.80
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        EC 2.7.1.82
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        EC 2.7.1.84
        EC 2.7.1.85
        EC 2.7.1.86
        EC 2.7.1.87
        EC 2.7.1.88
        EC 2.7.1.89
        EC 2.7.1.90
        EC 2.7.1.91
        EC 2.7.1.92
        EC 2.7.1.93
        EC 2.7.1.94
        EC 2.7.1.95
        EC 2.7.1.96
        EC 2.7.1.97
        EC 2.7.1.98
        EC 2.7.1.99
        EC 2.7.1.100
        EC 2.7.1.101
        EC 2.7.1.102
        EC 2.7.1.103
        EC 2.7.1.104
        EC 2.7.1.105
        EC 2.7.1.106
        EC 2.7.1.107
        EC 2.7.1.108
        EC 2.7.1.109
        EC 2.7.1.110
        EC 2.7.1.111
        EC 2.7.1.112
        EC 2.7.1.113
        EC 2.7.1.114
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        EC 2.7.1.116
        EC 2.7.1.117
        EC 2.7.1.118
        EC 2.7.1.119
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        EC 2.7.1.129
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        EC 2.7.1.131
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        EC 2.7.1.134
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        EC 2.7.1.136
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        EC 2.7.1.138
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        EC 2.7.1.141
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        EC 2.7.1.145
        EC 2.7.1.146
        EC 2.7.1.147
        EC 2.7.1.148
        EC 2.7.1.149
        EC 2.7.1.150
        EC 2.7.1.151
        EC 2.7.1.152
        EC 2.7.1.153
        EC 2.7.1.154
        EC 2.7.1.155
        EC 2.7.1.156
        EC 2.7.1.157
        EC 2.7.1.158
        EC 2.7.1.159
        EC 2.7.1.160
        EC 2.7.1.161
        EC 2.7.1.162
      EC 2.7.2
      EC 2.7.3
      EC 2.7.4
      EC 2.7.5
      EC 2.7.6
      EC 2.7.7
      EC 2.7.8
      EC 2.7.9
      EC 2.7.10
      EC 2.7.11
      EC 2.7.12
      EC 2.7.13
      EC 2.7.14
    EC 2.8
    EC 2.9
  EC 3: Hydrolases
  EC 4: Lyases
  EC 5: Isomerases
  EC 6: Ligases
  General information:
  Catalytic mechanism
  Enzyme kinetics
  Inhibitors
  Enzymes in industry

EC 2.7.1.153 - ATP:1- phosphatidyl- 1D- myo- inositol- 4,5- bisphosphate 3- phosphotransferase (phosphatidylinositol- 4,5- bisphosphate 3- kinase)



3D structures of EC 2.7.1.153 - phosphatidylinositol-4,5-bisphosphate 3-kinase in Protein Data Bank

updated: 29 May 2015, 1:12

In total: 114 PDB structures of EC 2.7.1.153 - phosphatidylinositol-4,5-bisphosphate 3-kinase:
  1. 3oaw: 4-methylpteridineones as Orally Active and Selective PI3K/MTOR Dual Inhibitors
  2. 3ml9: Discovery of The Highly Potent PI3K/MTOR Dual Inhibitor Pf-04691502 through Structure Based Drug Design
  3. 3ml8: Discovery of The Highly Potent PI3K/MTOR Dual Inhibitor Pf-04691502 through Structure Based Drug Design
  4. 3mjw: Pi3 Kinase Gamma with a Benzofuranone Inhibitor
  5. 3lj3: Pi3-kinase-gamma with a Pyrrolopyridine-benzofuran Inhibitor
  6. 3l54: Structure of PI3K Gamma with Inhibitor
  7. 3l17: Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-pi3-kinase and Dual Pan-pi3-kinase/mtor Inhibitors for The Treatment of Cancer
  8. 3l16: Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-pi3-kinase and Dual Pan-pi3-kinase/mtor Inhibitors for The Treatment of Cancer
  9. 3l13: Crystal Structures of Pan-pi3-kinase and Dual Pan-pi3- Kinase/mtor Inhibitors
  10. 3l08: Structure of PI3K Gamma with a Potent Inhibitor: Gsk2126458
  11. 3ibe: Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to Pi3 Kinase Gamma
  12. 3hiz: Crystal Structure of P110ALPHA H1047R Mutant in Complex with Nish2 of P85ALPHA
  13. 3hhm: Crystal Structure of P110ALPHA H1047R Mutant in Complex with Nish2 of P85ALPHA and The Drug Wortmannin
  14. 3ene: Complex of PI3K Gamma with an Inhibitor
  15. 3dpd: Achieving Multi-isoform PI3K Inhibition in a Series of Substituted 3,4-dihydro-2h-benzo[1,4]oxazines
  16. 3dbs: Structure of PI3K Gamma in Complex with Gdc0941
  17. 3cst: Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2
  18. 3csf: Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor Dw2
  19. 2x6k: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with Pi-103
  20. 2x6j: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with Pik-93
  21. 2x6i: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with Pik-90
  22. 2x6h: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34
  23. 2x6f: The Crystal Structure of The Drosophila Class III Pi3-kinase Vps34 in Complex with 3-methyladenine
  24. 2x38: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Ic87114.
  25. 2wxr: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA.
  26. 2wxq: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with As15.
  27. 2wxp: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Gdc-0941.
  28. 2wxo: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with As5.
  29. 2wxn: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Dl07.
  30. 2wxm: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Dl06.
  31. 2wxl: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Zstk474.
  32. 2wxk: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Ink666.
  33. 2wxj: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Ink654.
  34. 2wxi: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Sw30.
  35. 2wxh: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Sw14.
  36. 2wxg: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Sw13.
  37. 2wxf: The Crystal Structure of The Murine Class Ia Pi 3-kinase P110DELTA in Complex with Pik-39.
  38. 2a4z: Crystal Structure of Human PI3KGAMMA Complexed with As604850
  39. 2a5u: Crystal Structure of Human PI3KGAMMA Complexed with As605240
  40. 2v4l: Complex of Human Phosphoinositide 3-kinase Catalytic Subunit Gamma (p110 Gamma) with Pik-284
  41. 2v1y: Structure of a Phosphoinositide 3-kinase Alpha Adaptor- Binding Domain (abd) in a Complex with The Ish2 Domain from P85 Alpha
  42. 2rd0: Structure of a Human P110ALPHA/P85ALPHA Complex
  43. 2chw: A Pharmacological Map of The Pi3-k Family Defines a Role for P110 Alpha in Signaling: The Structure of Complex of Phosphoinositide 3-kinase Gamma with Inhibitor Pik-39
  44. 2chx: A Pharmacological Map of The Pi3-k Family Defines a Role for P110ALPHA in Signaling: The Structure of Complex of Phosphoinositide 3-kinase Gamma with Inhibitor Pik-90
  45. 2chz: A Pharmacological Map of The Pi3-k Family Defines a Role for P110ALPHA in Signaling: The Structure of Complex of Phosphoinositide 3-kinase Gamma with Inhibitor Pik-93
  46. 2enq: Solution Structure of The C2 Domain from Human Pi3-kinase P110 Subunit Alpha
  47. 3nzs: Structure-based Optimization of Pyrazolo -pyrimidine and -pyridine Inhibitors of Pi3-kinase
  48. 3nzu: Structure-based Optimization of Pyrazolo -pyrimidine and -pyridine Inhibitors of Pi3-kinase
  49. 3pre: Quinazolines with Intra-molecular Hydrogen Bonding Scaffold (imhbs) as PI3K/MTOR Dual Inhibitors.
  50. 3prz: Quinazolines with Intra-molecular Hydrogen Bonding Scaffold (imhbs) as PI3K/MTOR Dual Inhibitors.
  51. 3ps6: Quinazolines with Intra-molecular Hydrogen Bonding Scaffold (imhbs) as PI3K/MTOR Dual Inhibitors.
  52. 3apc: Crystal Structure of Human PI3K-GAMMA in Complex with Ch5132799
  53. 3apd: Crystal Structure of Human PI3K-GAMMA in Complex with Ch5108134
  54. 3apf: Crystal Structure of Human PI3K-GAMMA in Complex with Ch5039699
  55. 3qaq: Crystal Structure of PI3K-GAMMA in Complex with Triazine-benzimidazole 1
  56. 3qar: Crystal Structure of PI3K-GAMMA in Complex with Triazine-benzimidazole 32
  57. 3qjz: Crystal Structure of PI3K-GAMMA in Complex with Benzothiazole 1
  58. 3qk0: Crystal Structure of PI3K-GAMMA in Complex with Benzothiazole 82
  59. 3s2a: Crystal Structure of PI3K-GAMMA in Complex with a Quinoline Inhibitor
  60. 3r7q: Structure-based Design of Thienobenzoxepin Inhibitors of Pi3- Kinase
  61. 3r7r: Structure-based Design of Thienobenzoxepin Inhibitors of Pi3-kinase
  62. 3p2b: Crystal Structure of PI3K Gamma with 3-(2-morpholino-6-(pyridin-3- Ylamino)pyrimidin-4-yl)phenol
  63. 3zvv: Fragment Bound to PI3KINASE Gamma
  64. 3zw3: Fragment Based Discovery of a Novel and Selective Pi3 Kinase Inhibitor
  65. 3tl5: Discovery of Gdc-0980: a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-kinase (PI3K)/MAMMALIAN Target of Rapamycin (mtor) Kinase Inhibitor for The Treatment of Cancer
  66. 3t8m: Rational Design of PI3K-ALPHA Inhibitors That Exhibit Selectivity over The PI3K-BETA Isoform
  67. 4a55: Crystal Structure of P110ALPHA in Complex with Ish2 of P85ALPHA and The Inhibitor Pik-108
  68. 3sd5: Crystal Structure of PI3K Gamma with 5-(2,4-dimorpholinopyrimidin-6- Yl)-4-(trifluoromethyl)pyridin-2-amine
  69. 4anu: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
  70. 4anv: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
  71. 4anw: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
  72. 4anx: Complexes of PI3KGAMMA with Isoform Selective Inhibitors.
  73. 4aof: Selective Small Molecule Inhibitor Discovered by Chemoproteomic Assay Platform Reveals Regulation of Th17 Cell Differentiation by PI3KGAMMA
  74. 4ajw: Discovery and Optimization of New Benzimidazole- and Benzoxazole- Pyrimidone Selective PI3KBETA Inhibitors for The Treatment of Phosphatase and Tensin Homologue (pten)-deficient Cancers
  75. 4dk5: Crystal Structure of Human PI3K-GAMMA in Complex with a Pyridyl- Triazine Inhibitor
  76. 4fhj: Crystal Structure of PI3K-GAMMA in Complex with Imidazopyridine 2
  77. 4f1s: Crystal Structure of Human PI3K-GAMMA in Complex with a Pyridyl- Triazine-sulfonamide Inhibitor
  78. 4gb9: Potent and Highly Selective Benzimidazole Inhibitors of PI3K-DELTA
  79. 3tjp: Crystal Structure of PI3K Gamma with N6-(3,4-dimethoxyphenyl)-2- Morpholino-[4,5'-bipyrimidine]-2',6-diamine
  80. 4flh: Crystal Structure of Human PI3K-GAMMA in Complex with Amg511
  81. 4ful: Pi3 Kinase Gamma Bound to a Pyrmidine Inhibitor
  82. 4fjy: Crystal Structure of PI3K-GAMMA in Complex with Quinoline-indoline Inhibitor 24f
  83. 4fjz: Crystal Structure of PI3K-GAMMA in Complex with Pyrrolo-pyridine Inhibitor 63
  84. 4g11: X-ray Structure of PI3K-GAMMA Bound to a 4-(morpholin-4-yl)- (6-oxo-1, 6-dihydropyrimidin-2-yl)amide Inhibitor
  85. 3zim: Discovery of a Potent and Isoform-selective Targeted Covalent Inhibitor of The Lipid Kinase PI3KALPHA
  86. 4hle: Compound 21 (1-alkyl-substituted 1,2,4-triazoles)
  87. 4ezj: Potent and Selective Inhibitors of PI3K-DELTA: Obtaining Isoform Selectivity from The Affinity Pocket and Tryptophan Shelf
  88. 4ezk: Potent and Selective Inhibitors of PI3K-DELTA: Obtaining Isoform Selectivity from The Affinity Pocket and Tryptophan Shelf
  89. 4ezl: Potent and Selective Inhibitors of PI3K-DELTA: Obtaining Isoform Selectivity from The Affinity Pocket and Tryptophan Shelf
  90. 4fa6: Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3KA and Mtor
  91. 4fad: Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3KA and Mtor
  92. 4fhk: Crystal Structure of PI3K-GAMMA in Complex with Imidazopyridazine 19e
  93. 4kz0: Structure of PI3K Gamma with Imidazopyridine Inhibitors
  94. 4kzc: Structure of PI3K Gamma with Imidazopyridine Inhibitors
  95. 4bfr: Discovery and Optimization of Pyrimidone Indoline Amide PI3KBETA Inhibitors for The Treatment of Phosphatase and Tensin Homologue (pten)-deficient Cancers
  96. 4hvb: Catalytic Unit of PI3KG in Complex with PI3K/MTOR Dual Inhibitor Pf- 04979064
  97. 4j6i: Discovery of Thiazolobenzoxepin Pi3-kinase Inhibitors That Spare The Pi3-kinase Beta Isoform
  98. 4jps: Co-crystal Structures of The Lipid Kinase PI3K Alpha with Pan and Isoform Selective Inhibitors
  99. 4l1b: Crystal Structure of P110ALPHA Complexed with Nish2 of P85ALPHA
  100. 4l23: Crystal Structure of P110ALPHA Complexed with Nish2 of P85ALPHA and Pi-103
  101. 4l2y: Crystal Structure of P110ALPHA Complexed with Nish2 of P85ALPHA and Compound 9d
  102. 4ovu: Crystal Structure of P110ALPHA in Complex with Nish2 of P85ALPHA
  103. 4ovv: Crystal Structure of PI3KALPHA in Complex with Dic4-pip2
  104. 4ps3: Structure of PI3K Gamma in Complex with 1-[6-(5-methoxypyridin-3-yl)- 1,3-benzothiazol-2-yl]-3-[2-(1-propyl-1h-imidazol-4-yl)ethyl]urea
  105. 4ps7: Structure of PI3K Gamma in Complex with N-[6-(pyridin-3-yl)-1,3- Benzothiazol-2-yl]acetamide
  106. 4ps8: Structure of PI3K Gamma in Complex with N-[6-(5,6-dimethoxypyridin-3- Yl)-1,3-benzothiazol-2-yl]acetamide
  107. 4tuu: Isolated P110A Subunit of PI3KA Provides a Platform for Structure- Based Drug Design
  108. 4tv3: Isolated P110A Subunit of PI3KA Provides a Platform for Structure- Based Drug Design
  109. 4urk: PI3KG in Complex with Azd6482
  110. 4wwn: Crystal Structure of Human PI3K-GAMMA in Complex with (s)-n-(1-(7- Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9h-purin-6-amine Amg319 Inhibitor
  111. 4wwo: Crystal Structure of Human PI3K-GAMMA in Complex with Phenylquinoline Inhibitor N-{(1s)-1-[8-chloro-2-(3-fluorophenyl)quinolin-3-yl]ethyl}- 9h-purin-6-amine
  112. 4wwp: Crystal Structure of Human PI3K-GAMMA in Complex with Pyridinylquinoline Inhibitor N-{(1s)-1-[8-chloro-2-(2-methylpyridin- 3-yl)quinolin-3-yl]ethyl}-9h-purin-6-amine
  113. 4waf: Crystal Structure of a Novel Tetrahydropyrazolo[1,5-a]pyrazine in an Engineered PI3K Alpha
  114. 4xe0: Idelalisib Bound to The P110 Subunit of PI3K Delta
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