EC 1.14.13.70 - sterol,NADPH:oxygen oxidoreductase (14- methyl cleaving) (sterol 14- demethylase)

3D structures of EC 1.14.13.70 - sterol 14-demethylase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1h5z: Cytochrome P450 14 Alpha-sterol Demethylase (cyp51) from Mycobacterium Tuberculosis in Ferric Low-spin State
2. 3ld6: Crystal Structure of Human Lanosterol 14alpha-demethylase (cyp51) in Complex with Ketoconazole
3. 3l4d: Crystal Structure of Sterol 14-alpha Demethylase (cyp51) from Leishmania Infantum in Complex with Fluconazole
4. 3ksw: Crystal Structure of Sterol 14alpha-demethylase (cyp51) from Trypanosoma Cruzi in Complex with an Inhibitor Vnf ((4-(4- Chlorophenyl)-n-[2-(1h-imidazol-1-yl)-1-phenylethyl]benzamide)
5. 3khm: Crystal Structure of Sterol 14alpha-demethylase (cyp51) from Trypanosoma Cruzi in Complex with Inhibitor Fluconazole
6. 3k1o: Crystal Structure of Sterol 14-alpha Demethylase (cyp51) from Trypanosoma Cruzi in Complex with a Potential Antichagasic Drug, Posaconazole
7. 3juv: Crystal Structure of Human Lanosterol 14alpha-demethylase (cyp51)
8. 3jus: Crystal Structure of Human Lanosterol 14alpha-demethylase (cyp51) in Complex with Econazole
9. 3gw9: Crystal Structure of Sterol 14-alpha Demethylase (cyp51) from Trypanosoma Brucei Bound to an Inhibitor N-(1-(2,4- Dichlorophenyl)-2-(1h-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3, 4-oxaziazol-2-yl)benzamide
10. 3g1q: Crystal Structure of Sterol 14-alpha Demethylase (cyp51) from Trypanosoma Brucei in Ligand Free State
11. 1u13: Crystal Structure Analysis of The C37L/C151T/C442A-TRIPLE Mutant of Cyp51 from Mycobacterium Tuberculosis
12. 1x8v: Estriol-bound and Ligand-free Structures of Sterol 14alpha- Demethylase (cyp51)
13. 2x2n: X-ray Structure of Cyp51 from Trypanosoma Brucei in Complex with Posaconazole in Two Different Conformations
14. 2wx2: X-ray Structure of Cyp51 from The Human Pathogen Trypanosoma Cruzi in Complex with Fluconazole
15. 2wv2: X-ray Structure of Cyp51 from The Human Pathogen Trypanosoma Brucei in Complex with Fluconazole
16. 2wuz: X-ray Structure of Cyp51 from Trypanosoma Cruzi in Complex with Fluconazole in Alternative Conformation
17. 2w0b: Cyp51 of M. Tuberculosis Bound to an Inhibitor 3-{[(4- Methylphenyl)sulfonyl]amino}propyl Pyridin-4-ylcarbamate
18. 2w0a: Cyp51 of M. Tuberculosis Bound to an Inhibitor N-[(1s)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl] Cyclohexanecarboxamide
19. 2w09: Cyp51 of M. Tuberculosis Bound to an Inhibitor Cis-4- Methyl-n-[(1s)-3-(methylsulfanyl)-1-(pyridin-4- Ylcarbamoyl)propyl]cyclohexanecarboxamide
20. 2vku: 4,4'-dihydroxybenzophenone Mimics Sterol Substrate in The Binding Site of Sterol 14alpha-demethylase (cyp51) in The X-ray Structure of The Complex
21. 2bz9: Ligand-free Structure of Sterol 14alpha-demethylase from Mycobacterium Tuberculosis in P2(1) Space Group
22. 2ci0: High Throughput Screening and X-ray Crystallography Assisted Evaluation of Small Molecule Scaffolds for Cyp51 Inhibitors
23. 2cib: High Throughput Screening and X-ray Crystallography Assisted Evaluation of Small Molecule Scaffolds for Cyp51 Inhibitors
24. 3p99: Sterol 14alpha-demethylase (cyp51) from Trypanosoma Brucei in Complex with Delta7-14alpha-methylene-cyclopropyl-dihydrolanosterol
25. 6q2t: Human Sterol 14a-demethylase (cyp51) in Complex with The Functionally Irreversible Inhibitor (r)-n-(1-(3-chloro-4'-fluoro-[1,1'-biphenyl]- 4-yl)-2-(1h-imidazol-1-yl)ethyl)-4-(5-(3-fluoro-5-(5-fluoropyrimidin- 4-yl)phenyl)-1,3,4-oxadiazol-2-yl)benzamide
26. 6mi0: Crystal Structure of The P450 Domain of The Cyp51-ferredoxin Fusion Protein from Methylococcus Capsulatus, Ligand-free State
27. 3tik: Sterol 14-alpha Demethylase (cyp51) from Trypanosoma Brucei in Complex with The Tipifarnib Derivative 6-((4-chlorophenyl)(methoxy)(1-methyl- 1h-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin- 2(1h)-one
28. 6mcw: Crystal Structure of The P450 Domain of The Cyp51-ferredoxin Fusion Protein from Methylococcus Capsulatus, Complex with The Detergent Anapoe-x-114
29. 4h6o: Sterol 14-alpha Demethylase (cyp51)from Trypanosoma Cruzi in Complex with The Inhibitor Neu321 (1-(3-(4-chloro-3,5-dimethylphenoxy) Benzyl)-1h-imidazole
30. 6fmo: Crystal Structure of The Substrate (obtusifoliol)-bound and Ligand- Free I105F Mutant of Sterol 14-alpha Demethylase (cyp51) from Trypanosoma Cruzi
31. 4g3j: Sterol 14-alpha Demethylase (cyp51) from Trypanosoma Brucei in Complex with The Vni Derivative (r)-n-(1-(2,4-dichlorophenyl)-2-(1h-1,2,4- Triazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide [r- Vni-triazole (vnt)]
32. 4g7g: Sterol 14-alpha Demethylase (cyp51) from Trypanosoma Brucei in Complex with The Vni Derivative (r)-n-(1-(3,4'-difluorobiphenyl-4-yl)-2-(1h- Imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide [vni/vnf (vfv)]
33. 6cr2: Crystal Structure of Sterol 14-alpha Demethylase (CYP51B) from Aspergillus Fumigatus in Complex with The Vni Derivative N-(1-(2,4- Dichlorophenyl)-2-(1h-imidazol-1-yl)ethyl)-4-(5-(2-fluoro-4-(2,2,2- Trifluoroethoxy)phenyl)-1,3,4-oxadiazol-2-yl)benzamide
34. 3zg2: Sterol 14 Alpha-demethylase (cyp51) from Trypanosoma Cruzi in Complex with The Pyridine Inhibitor (s)-2-(4-chlorophenyl)-2- (pyridin-3-yl)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl) Ethanone (epl-bs1246,udo)
35. 3zg3: Sterol 14-alpha Demethylase (cyp51) from Trypanosoma Cruzi in Complex with The Pyridine Inhibitor N-(1-(5-( Trifluoromethyl)(pyridin-2-yl))piperidin-4yl)-n-(4-( Trifluoromethyl)phenyl)pyridin-3-amine (epl-bs967, Udd)
36. 4bjk: Cyp51 of Trypanosoma Brucei Bound to (s)-n-(3-(1h-indol-3- Yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-( 1,1'-biphenyl)-4-carboxamide
37. 4bmm: Crystal Structure of Trypanosoma Cruzi Cyp51 Bound to The Inhibitor (r)-n-(3-(1h-indol-3-yl)-1-oxo-1-(pyridin-4- Ylamino)propan-2-yl)- 2',3,5'-trifluoro-(1,1'-biphenyl)-4-carboxamide
38. 4by0: Crystal Structure of Trypanosoma Cruzi Cyp51 Bound to The Inhibitor (r)-n-(3-(1h-indol-3-yl)-1-oxo-1-(pyridin-4- Ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4- Carboxamide
39. 4c0c: Crystal Structure of Trypanosoma Cruzi Cyp51 Bound to The Inhibitor (r)-n-(3-(1h-indol-3-yl)-1-oxo-1-(pyridin-4- Ylamino)propan-2-yl)-4-(4-(2,4-difluorophenyl)piperazin-1- Yl)-2-fluorobenzamide.
40. 4c27: Crystal Structure of Trypanosoma Cruzi Cyp51 Bound to The Inhibitor (r)-n-(3-(1h-indol-3-yl)-1-oxo-1-(pyridin-4- 4-ylamino)propan-2-yl)-2-fluoro-4-(4-(4-(trifluoromethyl) Phenyl)piperazin-1-yl)benzamide
41. 4c28: Crystal Structure of Trypanosoma Cruzi Cyp51 Bound to The Inhibitor (r)-n-(3-(1h-indol-3-yl)-1-oxo-1-(pyridin-4- Ylamino)propan-2-yl)-4-(4-(4-chlorophenyl)piperazin-1-yl)- 2-fluorobenzamide.
42. 4ck8: Sterol 14-alpha Demethylase (cyp51)from Trypanosoma Cruzi in Complex with (r)-1-(2,4-dichlorophenyl)-2-(1h-imidazol-1-yl)ethyl 4-(4-(3,4-dichlorophenyl)piperazin-1-yl)phenylcarbamate (lfd)
43. 4ck9: Sterol 14-alpha Demethylase (cyp51)from Trypanosoma Cruzi in Complex with (s)-1-(4-chlorophenyl)-2-(1h-imidazol-1-yl) Ethyl 4-isopropylphenylcarbamate (lft)
44. 4cka: Sterol 14-alpha Demethylase (cyp51)from Trypanosoma Cruzi in Complex with (s)-1-(4-fluorophenyl)-2-(1h-imidazol-1-yl) Ethyl 4-isopropylphenylcarbamate (lfs)
45. 4coh: Crystal Structure of Trypanosoma Cruzi Cyp51 Bound to The Sulfonamide Derivative of The 4-aminopyridyl-based Inhibitor
46. 4lxj: Saccharomyces Cerevisiae Lanosterol 14-alpha Demethylase with Lanosterol Bound
47. 4uqh: Crystal Structure of Trypanosoma Cruzi Cyp51 Bound to The Inhibitor (r)-n-(3-(1h-indol-3-yl)-1-oxo-1-(pyridin-4- Ylamino)propan-2-yl)-4-(4-(3,4-difluorophenyl)piperazin-1- Yl)-2-fluorobenzamide.
48. 5v5z: Structure of Cyp51 from The Pathogen Candida Albicans
49. 4uvr: Binding Mode, Selectivity and Potency of N-indolyl- Oxopyridinyl-4-amino-propanyl-based Inhibitors Targeting Trypanosoma Cruzi Cyp51
50. 5tz1: Crystal Structure of Sterol 14-alpha Demethylase (cyp51) from Candida Albicans in Complex with The Tetrazole-based Antifungal Drug Candidate Vt1161 (vt1)
51. 5jlc: Structure of Cyp51 from The Pathogen Candida Glabrata
52. 5fsa: Crystal Structure of Sterol 14-alpha Demethylase (cyp51) from a Pathogenic Yeast Candida Albicans in Complex with The Antifungal Drug Posaconazole
53. 5frb: Crystal Structure of Sterol 14-alpha Demethylase (CYP51B) from a Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with a Tetrazole-based Inhibitor Vt-1598
54. 5esn: Saccharomyces Cerevisiae Cyp51 (lanosterol 14-alpha Demethylase) T322I Mutant Structure
55. 5esm: Saccharomyces Cerevisiae Cyp51 (lanosterol 14-alpha Demethylase) T322I Mutant Complexed with Fluconazole
56. 5esh: Saccharomyces Cerevisiae Cyp51 (lanosterol 14-alpha Demethylase) G73W Mutant in Complex with Itraconazole
57. 5esg: Saccharomyces Cerevisiae Cyp51 (lanosterol 14-alpha Demethylase) G73E Mutant Complexed with Itraconazole
58. 5esf: Saccharomyces Cerevisiae Cyp51 (lanosterol 14-alpha Demethylase) G73E Mutant Complexed with Fluconazole
59. 5ese: Saccharomyces Cerevisiae Cyp51 (lanosterol 14-alpha Demethylase) G73R Mutant Complexed with Fluconazole
60. 5eqb: Crystal Structure of Lanosterol 14-alpha Demethylase with Intact Transmembrane Domain Bound to Itraconazole
61. 5ajr: Sterol 14-alpha Demethylase (cyp51) from Trypanosoma Cruzi in Complex with The 1-tetrazole Derivative Vt-1161 ((r)-2-( 2,4-difluorophenyl)-1,1-difluoro-3-(1h-tetrazol-1-yl)-1-(5- (4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol)
62. 4uhi: Human Sterol 14-alpha Demethylase (cyp51) in Complex with Vfv in C121 Space Group
63. 4uhl: Human Sterol 14-alpha Demethylase (cyp51) in Complex with Vfv in P1 Space Group
64. 4uyl: Crystal Structure of Sterol 14-alpha Demethylase (CYP51B) from a Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Vni
65. 4uym: Crystal Structure of Sterol 14-alpha Demethylase (CYP51B) from a Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Voriconazole
66. 7jj1: Crystal Structure of The Sterol 14alpha-demethylase-ferredoxin (cyp51- Fx) Heme Domain and Architectural Comparison to The Whole Fusion Protein