EC 2.5.1.10 - geranyl- diphosphate:isopentenyl- diphosphate geranyl trans transferase ((2 E ,6 E ) - farnesyl diphosphate synthase)

3D structures of EC 2.5.1.10 - (2E,6E)-farnesyl diphosphate synthase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1fps: Crystal Structure of Recombinant Farnesyl Diphosphate Synthase at 2.6 Angstroms Resolution
2. 3pde: Crystal Structure of Geranylgeranyl Pyrophosphate Synthase from Lactobacillus Brevis Atcc 367 Complexed with Isoprenyl Diphosphate and Magnesium
3. 3npk: The Crystal Structure of Geranyltranstransferase from Campylobacter Jejuni
4. 3n6k: Human Fpps Complex with Nov_823
5. 3n5j: Human Fpps Complex with Nov_311
6. 3n5h: Human Fpps Complex with Nov_304
7. 3n49: Human Fpps Complex with Nov_292
8. 3n46: Human Fpps Complex with Nov_980 and Zoledronic Acid/mg2+
9. 3n45: Human Fpps Complex with Fbs_04 and Zoledronic Acid/mg2+
10. 3n3l: Human Fpps Complex with Fbs_03
11. 3n1w: Human Fpps Complex with Fbs_02
12. 3n1v: Human Fpps Complex with Fbs_01
13. 3m9u: Crystal Structure of Geranylgeranyl Pyrophosphate Synthase from Lactobacillus Brevis Atcc 367
14. 3lom: Crystal Structure of Geranyltransferase from Legionella Pneumophila
15. 3id0: Trypanosoma Cruzi Farnesyl Diphosphate Synthase Homodimer in Complex with 3-fluoro-1-(2-hydroxy-2,2-bisphosphono-ethyl) Pyridinium
16. 3icz: Trypanosoma Cruzi Farnesyl Diphosphate Synthase Homodimer in Complex with 1-(2,2-bis-phosphono-ethyl)-3-butyl-pyridinium and Isopentenyl Pyrophosphate
17. 3icn: Trypanosoma Cruzi Farnesyl Diphosphate Synthase Homodimer in Complex with Isopentenyl Pyrophosphate and 3-fluoro-1-(2- Hydroxy-2,2-bis-phosphono-ethyl)-pyridinium
18. 3icm: Trypanosoma Cruzi Farnesyl Diphosphate Synthase Homodimer in Complex with Isopentenyl Pyrophosphate, Mg2+ and 1-(2- Hydroxy-2,2-bis-phosphono-ethyl)-3-phenyl-pyridinium
19. 3ick: Trypanosoma Cruzi Farnesyl Diphosphate Synthase Homodimer in Complex with Minodronate and Isopentenyl Disphosphate
20. 3iba: Crystal Structure of The Complex of Trypanosoma Cruzi Farnesyl Diphosphate Synthase with Zoledronate, Ipp and Mg2+
21. 1rqi: Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Dimethylallyl S- Thiolodiphosphate
22. 1rqj: Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Risedronate
23. 3egt: T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph-722
24. 3efq: T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph-714
25. 3dyh: T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph-721
26. 3dyg: T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph-461
27. 3dyf: T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph-461 and Isopentyl Diphosphate
28. 3cp6: Crystal Structure of Human Farnesyl Diphosphate Synthase (T201A Mutant) Complexed with Mg and Biphosphonate Inhibitor
29. 3b7l: Human Farnesyl Diphosphate Synthase Complexed with Mg and Minodronate
30. 2z7i: S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Inhibitor Bph-742
31. 2z7h: S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Inhibitor Bph-210
32. 2z78: S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Bph-806
33. 2z52: S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Magnesium and Bph-23
34. 2z50: S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Bph-28
35. 2z4z: S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Magnesium and Bph-sc01
36. 2z4y: S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Magnesium and Bph-252
37. 2z4x: S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Magnesium and Bph-252 (p21)
38. 2z4w: S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Magnesium and Bph-749
39. 2z4v: S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Magnesium and Ggpp (inhibitory Site)
40. 1yhk: Trypanosoma Cruzi Farnesyl Diphosphate Synthase
41. 1yhm: Structure of The Complex of Trypanosoma Cruzi Farnesyl Disphosphate Synthase with Alendronate, Isopentenyl Diphosphate and Mg+2
42. 1yq7: Human Farnesyl Diphosphate Synthase Complexed with Risedronate
43. 1yv5: Human Farnesyl Diphosphate Synthase Complexed with Mg and Risedronate
44. 1zw5: X-ray Structure of Farnesyl Diphosphate Synthase Protein
45. 2rah: Human Fdps Synthase in Complex with Novel Inhibitor
46. 2qis: Crystal Structure of Human Farnesyl Pyrophosphate Synthase T210S Mutant Bound to Risedronate
47. 2q80: Crystal Structure of Human Geranylgeranyl Pyrophosphate Synthase Bound to Ggpp
48. 2p1c: T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph-210
49. 2opn: Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph-527
50. 2opm: Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph-461
51. 2ogd: T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph-527
52. 6c57: Crystal Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D) in Complex with Bisphosphonate Inhibitor Fv0109
53. 6c56: Crystal Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D) in Its Apo Form
54. 2ewg: T. Brucei Farnesyl Diphosphate Synthase Complexed with Minodronate
55. 2f7m: Crystal Structure of Unliganded Human Fpps
56. 2f89: Crystal Structure of Human Fpps in Complex with Pamidronate
57. 2f8c: Crystal Structure of Fpps in Complex with Zoledronate
58. 2f8z: Crystal Structure of Human Fpps in Complex with Zoledronate and Isopentenyl Diphosphate
59. 2f92: Crystal Structure of Human Fpps in Complex with Alendronate
60. 2f94: Crystal Structure of Human Fpps in Complex with Ibandronate
61. 2f9k: Crystal Structure of Human Fpps in Complex with Zoledronate and Zn2+
62. 2for: Crystal Structure of The Shigella Flexneri Farnesyl Pyrophosphate Synthase Complex with an Isopentenyl Pyrophosphate
63. 2ftz: Crystal Structure of Geranyltranstransferase (ec 2.5.1.10) (tm0161) from Thermotoga Maritima at 1.90 a Resolution
64. 2h8o: The 1.6a Crystal Structure of The Geranyltransferase from Agrobacterium Tumefaciens
65. 2i19: T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate
66. 6ww1: Crystal Structure of The Lmfpps Mutant E97Y
67. 6w7i: Lmfpps Mutant T164W in Complex with 476a, Ipp & Ca
68. 6vjc: Lmfpps Mutant T164Y in Complex with 476a, Ipp & Ca
69. 3rye: Human Fdps Synthase in Complex with a N-methyl Pyridinum Bisphosphonate
70. 3s4j: Human Fdps Synthase in Complex with a Rigid Analog of Risedronate
71. 3ts7: Crystal Structure of Farnesyl Diphosphate Synthase (target Efi-501951) from Methylococcus Capsulatus
72. 6r4v: Crystal Structure of Human Geranylgeranyl Diphosphate Synthase Bound to Ibandronate
73. 6oah: Crystal Structure of Human Fpps in Complex with an Allosteric Inhibitor Yf-02-78
74. 6oag: Crystal Structure of Human Fpps in Complex with an Allosteric Inhibitor Yf-02-82
75. 4dem: Crystal Structure of Human Fpps in Complex with Ys_04_70
76. 6n83: Crystal Structure of Human Fpps in Complex with an Allosteric Inhibitor Yf-02037
77. 6n82: Crystal Structure of Human Fpps in Complex with an Allosteric Inhibitor Yf-02037
78. 6n7z: Crystal Structure of Human Fpps in Complex with an Allosteric Inhibitor Yf-02037
79. 6n7y: Crystal Structure of Human Fpps in Complex with an Allosteric Inhibitor Mit-01-102
80. 4dwb: Crystal Structure of Trypanosoma Cruzi Farnesyl Diphosphate Synthase in Complex with [2-(n-pentylamino)ethane-1,1-diyl]bisphosphonic Acid and Mg2+
81. 4dwg: Crystal Structure of Trypanosome Cruzi Farnesyl Diphosphate Synthase in Complex with [2-(n-heptylamino)ethane-1,1-diyl]bisphosphonic Acid and Mg2+
82. 4dxj: Crystal Structure of Trypanosome Cruzi Farnesyl Diphosphate Synthase in Complex with [2-(n-propylamino)ethane-1,1-diyl]bisphosphonic Acid and Mg2+
83. 4dzw: Crystal Structure of Trypanosome Cruzi Farnesyl Diphosphate Synthase in Complex with [2-(cyclohexylamino)ethane-1,1-diyl]bisphosphonic Acid and Mg2+
84. 4e1e: Crystal Structure of Trypanosome Cruzi Farnesyl Diphosphate Synthase in Complex with [2-(n-hexylamino)ethane-1,1-diyl]bisphosphonic Acid and Mg2+
85. 4h5c: Crystal Structure of Human Fpps in Ternary Complex with Ys0470 and Inorganic Phosphate
86. 4h5d: Crystal Structure of Human Fpps in Ternary Complex with Ys0470 and Inorganic Pyrophosphate
87. 4h5e: Crystal Structure of Human Fpps in Ternary Complex with Ys0470 and Isopentenyl Pyrophosphate
88. 4ga3: Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with Bph-1260
89. 6g32: Crystal Structure of Human Geranylgeranyl Diphosphate Synthase Mutant D188Y
90. 6g31: Crystal Structure of Human Geranylgeranyl Diphosphate Synthase Mutant D188Y Bound to Zoledronate
91. 4kkm: Crystal Structure of a Fpp/gfpp Synthase (target Efi-501952) from Zymomonas Mobilis, Apo Structure
92. 4kk2: Crystal Structure of a Chimeric Fpp/gfpp Synthase (target Efi-502313c) from Artemisia Spiciformis (1-72:gi751454468,73-346:gi75233326), Apo Structure
93. 4lfe: Crystal Structure of Geranylgeranyl Diphosphate Synthase Sub1274 (target Efi-509455) from Streptococcus Uberis 0140j with Bound Magnesium and Isopentyl Diphosphate, Partially Liganded Complex;
94. 4lfg: Crystal Structure of Geranylgeranyl Diphosphate Synthase Sub1274 (target Efi-509455) from Streptococcus Uberis 0140j with Bound Magnesium and Isopentyl Diphosphate, Fully Liganded Complex;
95. 4lls: Crystal Structure of a Farnesyl Diphosphate Synthase from Roseobacter Denitrificans Och 114, Target Efi-509393, with Ipp, Gspp, and Calcium Bound in Active Site
96. 4llt: Crystal Structure of a Farnesyl Diphosphate Synthase from Roseobacter Denitrificans Och 114, Target Efi-509393, with Two Ipp and Calcium Bound in Active Site
97. 3zcd: Native Structure of Farnesyl Pyrophosphate Synthase from Pseudomonas Aeruginosa Pa01.
98. 3zl6: Native Structure of Farnesyl Pyrophosphate Synthase from Pseudomonas Aeruginosa Pao1, with Bound Fragment Km10833.
99. 3zmb: Native Structure of Farnesyl Pyrophosphate Synthase from Pseudomonas Aeruginosa Pa01, with Bound Fragment Spb02696.
100. 3zmc: Native Structure of Farnesyl Pyrophosphate Synthase from Pseudomonas Aeruginosa Pa01, with Bound Substrate Molecule Geranyl Pyrophosphate.
101. 3zou: Native Structure of Farnesyl Pyrophosphate Synthase from Pseudomonas Aeruginosa Pa01, with Bound Fragment Spb02696, and Substrate Geranyl Pyrophosphate.
102. 4jvj: Crystal Structure of Human Fpps in Complex with Magnesium, Cl01131, and Sulfate
103. 4jzb: Crystal Structure of Leshmaniasis Major Farnesyl Diphosphate Synthase in Complex with 1-(2-hydroxy-2,2-diphosphonoethyl)-3- Phenylpyridinium, Ipp and Ca2+
104. 4jzx: Crystal Structure of Leshmaniasis Major Farnesyl Diphosphate Synthase in Complex with 3-butyl-1-(2,2-diphosphonoethyl)pyridinium, Ipp and Ca2+
105. 4k10: Crystal Structure of Leshmaniasis Major Farnesyl Diphosphate Synthase in Complex with 3-fluoro-1-(2-hydroxy-2,2-diphosphonoethyl)pyridinium and Mg2+
106. 4kfa: Crystal Structure of Human Farnesyl Pyrophosphate Synthase (T201A Mutant) Complexed with Mg and Zoledronate
107. 4kpd: Crystal Structure of Human Farnesyl Pyrophosphate Synthase (Y204F) Mutant Complexed with Mg, Risedronate and Isopentenyl Pyrophosphate
108. 4kpj: Crystal Structure of Farnesyl Pyrophosphate Synthase (Y204A) Mutant Complexed with Mg, Pamidronate
109. 4kq5: Crystal Structure of Human Farnesyl Pyrophosphate Synthase Mutant (Y204A) Complexed with Mg and Zoledronate
110. 4kqs: Crystal Structure of Farnesyl Pyrophosphate Synthase Mutant (Y204A) Complexed with Mg, Risedronate and Isopentenyl Pyrophosphate
111. 4kqu: Crystal Structure of Farnesyl Synthase Mutant (Y204A) Complexed with Mg, Alendronate and Isopentenyl Pyrophosphate
112. 4l2x: Crystal Structure of Human Fpps in Complex with Magnesium, Cl02134, and Inorganic Pyrophosphate
113. 4lfv: Crystal Structure of Human Fpps in Complex with Ys0470 and Two Molecules of Inorganic Phosphate
114. 4lpg: Crystal Structure of Human Fpps in Complex with Cl01131
115. 4lph: Crystal Structure of Human Fpps in Complex with Cl03093
116. 4n9u: The Role of Lysine 200 in The Human Farnesyl Pyrophosphate Synthase Catalytic Mechanism and The Mode of Inhibition by The Nitrogen- Containing Bisphosphonates
117. 4ng6: The Effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (fpps) Mutations on The Catalytic Activity, Crystal Structure and Inhibition by Nitrogen Containing Bisphosphonates
118. 4nke: The Effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (fpps) Mutations on The Catalytic Activity, Crystal Structure and Inhibition by Nitrogen Containing Bisphosphonates
119. 4nkf: The Effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (fpps) Mutations on The Catalytic Activity, Crystal Structure and Inhibition by Nitrogen Containing Bisphosphonates
120. 4nua: The Effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (fpps) Mutations on The Catalytic Activity, Crystal Structure and Inhibition by Nitrogen Containing Bisphosphonates
121. 4p0v: Crystal Structure of Human Farnesyl Diphosphoate Synthase in Complex with Zoledronate and Taxodione
122. 4p0w: Human Farnesyl Diphosphate Synthase in Complex with Arenarone and Zoledronate
123. 4p0x: Human Farnesyl Diphosphate Synthase in Complex with Taxodione
124. 5ygi: Crystal Structure of Human Fpps in Complex with an Inhibitor Thz93
125. 4n1z: Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with Bph-1222
126. 5ksx: Crystal Structure of Human Fpps in Complex with an Allosteric Inhibitor Am-02-072
127. 5jv2: Crystal Structure of Human Fpps in Complex with an Allosteric Inhibitor Mit-01-055
128. 5jv1: Crystal Structure of Human Fpps in Complex with an Allosteric Inhibitor Cl-08-066
129. 5jv0: Crystal Structure of Human Fpps in Complex with an Allosteric Inhibitor Cl-08-038
130. 5juz: Crystal Structure of Human Fpps in Complex with an Allosteric Inhibitor Cl-06-057
131. 5ja0: Crystal Structure of Human Fpps with Allosterically Bound Fpp
132. 5e8l: Crystal Structure of Geranylgeranyl Pyrophosphate Synthase 11 from Arabidopsis Thaliana
133. 5e8k: Crystal Structure of Polyprenyl Pyrophosphate Synthase 2 from Arabidopsis Thaliana
134. 5e8h: Crystal Structure of Geranylfarnesyl Pyrophosphate Synthases 2 from Arabidopsis Thaliana
135. 5djv: Crystal Structure of Human Fpps in Complex with Biaryl Compound 8e
136. 5djr: Crystal Structure of Human Fpps in Complex with Biaryl Compound 6
137. 5djp: Crystal Structure of Human Fpps in Complex with Biaryl Compound 5
138. 5diq: Crystal Structure of Human Fpps in Complex with Salicylic Acid Derivative 3a
139. 5dgs: Crystal Structure of Human Fpps in Complex with The Monophosphonate Compound 15
140. 5dgn: Crystal Structure of Human Fpps in Complex with Compound 13
141. 5dgm: Crystal Structure of Human Fpps in Complex with Monophosphonate Compound 7
142. 5cg6: Neutron Crystal Structure of Human Farnesyl Pyrophosphate Synthase in Complex with Risedronate and Isopentenyl Pyrophosphate
143. 5cg5: Neutron Crystal Structure of Human Farnesyl Pyrophosphate Synthase in Complex with Risedronate
144. 4nfi: Crystal Structure of Human Fpps in Complex with Magnesium and Jds05120
145. 4nfj: Crystal Structure of Human Fpps in Complex with Magnesium, Jds05120, and Sulfate
146. 4nfk: Crystal Structure of Human Fpps in Complex with Nickel, Jds05120, and Sulfate
147. 4ogu: The Effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (fpps) Mutations on The Catalytic Activity, Crystal Structure and Inhibition by Nitrogen Containing Bisphosphonates
148. 5ayp: Crystal Structure of Bacillus Stearothermophilus Farnesyl Pyrophosphate Synthase
149. 5ahu: T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph-1326
150. 5ael: T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph-597
151. 4qxs: Crystal Structure of Human Fpps in Complex with Wc01088
152. 4umj: Native Structure of Farnesyl Pyrophosphate Synthase from Pseudomonas Aeruginosa Pa01, with Bound Ibandronic Acid Molecules.
153. 4q23: The Role of Threonine 201 and Tyrosine 204 in The Human Farnesyl Pyrophosphate Synthase Catalytic Mechanism and The Mode of Inhibition by The Nitrogen-containing Bisphosphonates
154. 4pvx: Crystal Structure of Human Fpps in Complex with [({4-[4- (cyclopropyloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic Acid)
155. 4pvy: Crystal Structure of Human Fpps in Complex with [({5-[4-(propan-2- Yloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic Acid)
156. 4rxa: Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with Bph-1358
157. 4qpf: New Lower Bone Affinity Bisphosphonate Drug Design for Effective Use in Diseases Characterized by Abnormal Bone Resorption
158. 4xqr: Crystal Structure of Unliganded Human Fpps at 2.15 Angstrom Resolution
159. 4xqs: Crystal Structure of Human Fpps in Complex with One Magnesium Ion
160. 4xqt: Crystal Structure of Human Fpps in Complex with Three Magnesium Ions
161. 7lbj: Crystal Structure of Octaprenyl Diphosphate Synthase from Stenotrophomonas Maltophilia