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enzyme (lysozyme)

 
Enzymes
  Enzyme classes:
  EC 1: Oxidoreductases
    EC 1.1
    EC 1.2
    EC 1.3
    EC 1.4
    EC 1.5
      EC 1.5.1
        EC 1.5.1.1
        EC 1.5.1.2
        EC 1.5.1.3
        EC 1.5.1.4
        EC 1.5.1.5
        EC 1.5.1.6
        EC 1.5.1.7
        EC 1.5.1.8
        EC 1.5.1.9
        EC 1.5.1.10
        EC 1.5.1.11
        EC 1.5.1.12
        EC 1.5.1.13
        EC 1.5.1.14
        EC 1.5.1.15
        EC 1.5.1.16
        EC 1.5.1.17
        EC 1.5.1.18
        EC 1.5.1.19
        EC 1.5.1.20
        EC 1.5.1.21
        EC 1.5.1.22
        EC 1.5.1.23
        EC 1.5.1.24
        EC 1.5.1.25
        EC 1.5.1.26
        EC 1.5.1.27
        EC 1.5.1.28
        EC 1.5.1.29
        EC 1.5.1.30
        EC 1.5.1.31
        EC 1.5.1.32
        EC 1.5.1.33
        EC 1.5.1.34
        EC 1.5.1.35
      EC 1.5.3
      EC 1.5.4
      EC 1.5.7
      EC 1.5.8
      EC 1.5.99
    EC 1.6
    EC 1.7
    EC 1.8
    EC 1.9
    EC 1.10
    EC 1.11
    EC 1.12
    EC 1.13
    EC 1.14
    EC 1.15
    EC 1.16
    EC 1.17
    EC 1.18
    EC 1.19
    EC 1.20
    EC 1.21
    EC 1.97
    EC 1.98
    EC 1.99
  EC 2: Transferases
  EC 3: Hydrolases
  EC 4: Lyases
  EC 5: Isomerases
  EC 6: Ligases
  General information:
  Catalytic mechanism
  Enzyme kinetics
  Inhibitors
  Enzymes in industry

EC 1.5.1.3 - 5,6,7,8- tetrahydrofolate:NADP + oxidoreductase (dihydrofolate reductase)



3D structures of EC 1.5.1.3 - dihydrofolate reductase in Protein Data Bank

updated: 22 January 2021, 10:45

In total: 464 PDB structures of EC 1.5.1.3 - dihydrofolate reductase:
  1. 1ai9: Candida Albicans Dihydrofolate Reductase
  2. 1ao8: Dihydrofolate Reductase Complexed with Methotrexate, Nmr, 21 Structures
  3. 1aoe: Candida Albicans Dihydrofolate Reductase Complexed with Dihydro-nicotinamide-adenine-dinucleotide Phosphate (nadph) and 1,3-diamino-7-(1-ethyepropye)-7h-pyrralo-[3,2- F]quinazoline (gw345)
  4. 1boz: Structure-based Design and Synthesis of Lipophilic 2,4- Diamino-6-substituted Quinazolines and Their Evaluation as Inhibitors of Dihydrofolate Reductase and Potential Antitumor Agents
  5. 1bzf: Nmr Solution Structure and Dynamics of The Complex of Lactobacillus Casei Dihydrofolate Reductase with The New Lipophilic Antifolate Drug Trimetrexate, 22 Structures
  6. 1cd2: Ligand Induced Conformational Changes in The Crystal Structures of Pneumocystis Carinii Dihydrofolate Reductase Complexes with Folate and Nadp+
  7. 1cz3: Dihydrofolate Reductase from Thermotoga Maritima
  8. 1d1g: Dihydrofolate Reductase from Thermotoga Maritima
  9. 1daj: Comparison of Ternary Complexes of Pneumocystis Carinii and Wild Type Human Dihydrofolate Reductase with Coenzyme Nadph and a Novel Classical Antitumor Furo[2,3d]pyrimidine Antifolate
  10. 1ddr: Molecule: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with Methotrexate and Urea
  11. 1dds: Molecule: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with Methotrexate
  12. 1df7: Dihydrofolate Reductase of Mycobacterium Tuberculosis Complexed with Nadph and Methotrexate
  13. 1dg5: Dihydrofolate Reductase of Mycobacterium Tuberculosis Complexed with Nadph and Trimethoprim
  14. 1dg7: Dihydrofolate Reductase of Mycobacterium Tuberculosis Complexed with Nadph and 4-bromo Wr99210
  15. 1dg8: Dihydrofolate Reductase of Mycobacterium Tuberculosis Complexed with Nadph
  16. 1dhf: Crystal Structures of Recombinant Human Dihydrofolate Reductase Complexed with Folate and 5-deazofolate
  17. 1dhi: Long-range Structural Effects in a Second-site Revertant of a Mutant Dihydrofolate Reductase
  18. 1dhj: Long-range Structural Effects in a Second-site Revertant of a Mutant Dihydrofolate Reductase
  19. 1dis: Dihydrofolate Reductase (e.c.1.5.1.3) Complex with Brodimoprim-4,6-dicarboxylate
  20. 1diu: Dihydrofolate Reductase (e.c.1.5.1.3) Complex with Brodimoprim-4,6-dicarboxylate
  21. 1dlr: Methotrexate-resistant Variants of Human Dihydrofolate Reductase with Substitution of Leucine 22: Kinetics, Crystallography and Potential as Selectable Markers
  22. 1dls: Methotrexate-resistant Variants of Human Dihydrofolate Reductase with Substitution of Leucine 22: Kinetics, Crystallography and Potential as Selectable Markers
  23. 1dr1: 2.2 Angstroms Crystal Structure of Chicken Liver Dihydrofolate Reductase Complexed with Nadp+ and Biopterin
  24. 1dr2: 2.3 Angstroms Crystal Structure of Chicken Liver Dihydrofolate Reductase Complexed with Thionadp+ and Biopterin
  25. 1dr3: 2.3 Angstroms Crystal Structure of Chicken Liver Dihydrofolate Reductase Complexed with Thionadp+ and Biopterin
  26. 1dr4: Crystal Structures of Organomercurial-activated Chicken Liver Dihydrofolate Reductase Complexes
  27. 1dr5: Crystal Structures of Organomercurial-activated Chicken Liver Dihydrofolate Reductase Complexes
  28. 1dr6: Crystal Structures of Organomercurial-activated Chicken Liver Dihydrofolate Reductase Complexes
  29. 1dr7: Crystal Structures of Organomercurial-activated Chicken Liver Dihydrofolate Reductase Complexes
  30. 1dra: Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-induced Conformational Changes and Cooperativity in Binding
  31. 1drb: Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-induced Conformational Changes and Cooperativity in Binding
  32. 1dre: Dihydrofolate Reductase Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  33. 1drf: Crystal Structure of Human Dihydrofolate Reductase Complexed with Folate
  34. 1drh: Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-dideazatetrahydrofolate: Mechanistic Implications
  35. 1dyh: Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-dideazatetrahydrofolate: Mechanistic Implications
  36. 1dyi: Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-dideazatetrahydrofolate: Mechanistic Implications
  37. 1dyj: Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-dideazatetrahydrofolate: Mechanistic Implications
  38. 1dyr: The Structure of Pneumocystis Carinii Dihydrofolate Reductase to 1.9 Angstroms Resolution
  39. 1e26: Design, Synthesis and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent.
  40. 1hfp: Comparison of Ternary Crystal Complexes of Human Dihydrofolate Reductase with Nadph and a Classical Antitumor Furopyrimdine
  41. 1hfq: Comparison of Ternary Crystal Complexes of Human Dihydrofolate Reductase with Nadph and a Classical Antitumor Furopyrimdine
  42. 1hfr: Comparison of Ternary Crystal Complexes of Human Dihydrofolate Reductase with Nadph and a Classical Antitumor Furopyrimdine
  43. 1ia1: Candida Albicans Dihydrofolate Reductase Complexed with Dihydro-nicotinamide-adenine-dinucleotide Phosphate (nadph) and 5-(phenylsulfanyl)-2,4-quinazolinediamine (gw997)
  44. 1ia2: Candida Albicans Dihydrofolate Reductase Complexed with Dihydro-nicotinamide-adenine-dinucleotide Phosphate (nadph) and 5-[(4-methylphenyl)sulfanyl]-2,4- Quinazolinediamine (gw578)
  45. 1ia3: Candida Albicans Dihydrofolate Reductase Complex in Which The Dihydronicotinamide Moiety of Dihydro-nicotinamide- Adenine-dinucleotide Phosphate (nadph) Is Displaced by 5- [(4-tert-butylphenyl)sulfanyl]-2,4-quinazolinediamine (gw995)
  46. 1ia4: Candida Albicans Dihydrofolate Reductase Complex in Which The Dihydronicotinamide Moiety of Dihydro-nicotinamide- Adenine-dinucleotide Phosphate (nadph) Is Displaced by 5- {[4-(4-morpholinyl)phenyl]sulfanyl}-2,4-quinazolinediamin (gw2021)
  47. 1j3i: Wild-type Plasmodium Falciparum Dihydrofolate Reductase- Thymidylate Synthase (pfdhfr-ts) Complexed with Wr99210, Nadph, and Dump
  48. 1j3j: Double Mutant (C59R+S108N) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts) Complexed with Pyrimethamine, Nadph, and Dump
  49. 1j3k: Quadruple Mutant (N51I+C59R+S108N+I164L) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts) Complexed with Wr99210, Nadph, and Dump
  50. 1jol: The Crystal Structure of The Binary Complex between Folinic Acid (leucovorin) and E. Coli Dihydrofolate Reductase
  51. 1jom: The Crystal Structure of The Binary Complex between Folinic Acid (leucovorin) and E. Coli Dihydrofolate Reductase
  52. 1juv: Crystal Structure Analysis of Dihydrofolate Reductase from Bacteriophage T4
  53. 8dfr: Refined Crystal Structures of Chicken Liver Dihydrofolate Reductase. 3 Angstroms Apo-enzyme and 1.7 Angstroms Nadph Holo-enzyme Complex
  54. 7dfr: Crystal Structures of Escherichia Coli Dihydrofolate Reductase. The Nadp+ Holoenzyme and The Folate(dot)nadp+ Ternary Complex. Substrate Binding and a Model for The Transition State
  55. 6dfr: Crystal Structures of Escherichia Coli Dihydrofolate Reductase. The Nadp+ Holoenzyme and The Folate(dot)nadp+ Ternary Complex. Substrate Binding and a Model for The Transition State
  56. 5dfr: Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-induced Conformational Changes and Cooperativity in Binding
  57. 4dfr: Crystal Structures of Escherichia Coli and Lactobacillus Casei Dihydrofolate Reductase Refined at 1.7 Angstroms Resolution. I. General Features and Binding of Methotrexate
  58. 4cd2: Ligand Induced Conformational Changes in The Crystal Structures of Pneumocystis Carinii Dihydrofolate Reductase Complexes with Folate and Nadp+
  59. 1klk: Crystal Structure of Pneumocystis Carinii Dihydrofolate Reductase Ternary Complex with Pt653 and Nadph
  60. 1kms: Human Dihydrofolate Reductase Complexed with Nadph and 6- ([5-quinolylamino]methyl)-2,4-diamino-5-methylpyrido[2,3- D]pyrimidine (sri-9439), a Lipophilic Antifolate
  61. 1kmv: Human Dihydrofolate Reductase Complexed with Nadph and (z)- 6-(2-[2,5-dimethoxyphenyl]ethen-1-yl)-2,4-diamino-5- Methylpyrido[2,3-d]pyrimidine (sri-9662), a Lipophilic Antifolate
  62. 3nxv: Preferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for The E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes with Nadph and Human Dihydrofolate Reductase
  63. 3nxt: Preferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for The E-and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2m,3-d]pyrimidines as Ternary Complexes with Nadph and Human Dihydrofolate Reductase
  64. 3nxr: Perferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for The E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes with Nadph and Human Dihydrofolate Reductase
  65. 3nxo: Perferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for The E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes with Nadph and Human Dihydrofolate Reductase
  66. 1lud: Solution Structure of Dihydrofolate Reductase Complexed with Trimethoprim and Nadph, 24 Structures
  67. 1ly3: Analysis of Quinazoline and Pyridopyrimidine N9-c10 Reversed Bridge Antifolates in Complex with Nadp+ and Pneumocystis Carinii Dihydrofolate Reductase
  68. 1ly4: Analysis of Quinazoline and Pyrido[2,3d]pyrimidine N9-c10 Reversed Bridge Antifolates in Complex with Nadp+ and Pneumocystis Carinii Dihydrofolate Reductase
  69. 1m78: Candida Albicans Dihydrofolate Reductase Complexed with Dihydro-nicotinamide-adenine-dinucleotide Phosphate (nadph) and 5-chloryl-2,4,6-quinazolinetriamine (gw1225)
  70. 1m79: Candida Albicans Dihydrofolate Reductase Complexed with Dihydro-nicotinamide-adenine-dinucleotide Phosphate (nadph) and 5-(4-methoxyphenoxy)-2,4-quinazolinediamine (gw1466)
  71. 1m7a: Candida Albicans Dihydrofolate Reductase Complexed with Dihydro-nicotinamide-adenine-dinucleotide Phosphate (nadph) and 7-[2-methoxy-1-(methoxymethyl)ethyl]-7h- Pyrrolo[3,2-f] Quinazoline-1,3-diamine (gw557)
  72. 1mvs: Analysis of Two Polymorphic Forms of a Pyrido[2,3- D]pyrimidine N9-c10 Reverse-bridge Antifolate Binary Complex with Human Dihydrofolate Reductase
  73. 1mvt: Analysis of Two Polymorphic Forms of a Pyrido[2,3- D]pyrimidine N9-c10 Reverse-bridge Antifolate Binary Complex with Human Dihydrofolate Reductase
  74. 3m09: F98Y Tmp-resistant Dihydrofolate Reductase from Staphylococcus Aureus with Inhibitor Rab1
  75. 3m08: Wild Type Dihydrofolate Reductase from Staphylococcus Aureus with Inhibitor Rab1
  76. 3lg4: Staphylococcus Aureus V31Y, F92I Mutant Dihydrofolate Reductase Complexed with Nadph and 5-[(3s)-3-(5-methoxy-2',6'-dimethylbiphenyl- 3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
  77. 3kjs: Crystal Structure of T. Cruzi Dhfr-ts with 3 High Affinity Dhfr Inhibitors: Dq1 Inhibitor Complex
  78. 1ohj: Human Dihydrofolate Reductase, Monoclinic (p21) Crystal Form
  79. 1ohk: Human Dihydrofolate Reductase, Orthorhombic (p21 21 21) Crystal Form
  80. 3k74: Disruption of Protein Dynamics by an Allosteric Effector Antibody
  81. 3k47: Alternate Binding Modes Observed for The E- and Z-isomers of 2,4- Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with Nadph and Mouse Dihydrofolate Reductase
  82. 3k45: Alternate Binding Modes Observed for The E- and Z-isomers of 2,4- Diaminofuro[2,3d]pyrimidines as Ternary Complexes with Nadph and Mouse Dihydrofolate Reductase
  83. 3jwm: Crystal Structure of Bacillus Anthracis Dihydrofolate Reductase Complexed with Nadph and (s)-2,4-diamino-5-(3-methoxy-3-(3,4,5- Trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (UCP114A)
  84. 3jwk: Crystal Structure of Bacillus Anthracis (Y102F) Dihydrofolate Reductase Complexed with Nadph and (s)-2,4-diamino-5-(3-methoxy-3-(3, 4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (UCP114A)
  85. 3jwf: Crystal Structure of Bacillus Anthracis (Y102F) Dihydrofolate Reductase Complexed with Nadph and (r)-2,4-diamino-5-(3-hydroxy-3-(3, 4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (UCP113A)
  86. 3jwc: Crystal Structure of Bacillus Anthracis (Y102F) Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-(3-(3,4,5- Trimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120A)
  87. 3jw5: Crystal Structure of Bacillus Anthracis (Y102F) Dihydrofolate Reductase Complexed with Nadph and Trimethoprim
  88. 3jw3: Crystal Structure of Bacillus Anthracis (F96I) Dihydrofolate Reductase Complexed with Nadph and Trimethoprim
  89. 3jvx: Crystal Structure of Bacillus Anthracis Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl) Prop-1-ynyl)-6-ethylpyrimidine (UCP120A)
  90. 3jsu: Quadruple MUTANT(N51I+C59R+S108N+I164L) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase(pfdhfr-ts) Complexed with Qn254, Nadph, and Dump
  91. 3ix9: Crystal Structure of Streptococcus Pneumoniae Dihydrofolate Reductase - Sp9 Mutant
  92. 1pd8: Analysis of Three Crystal Structure Determinations of a 5- Methyl-6-n-methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase
  93. 1pd9: Analysis of Three Crystal Structure Determinations of a 5- Methyl-6-n-methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase
  94. 1pdb: Analysis of Three Crystal Structure Determinations of a 5- Methyl-6-n-methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase
  95. 3iro: Trypanosoma Cruzi Dihydrofolate Reductase-thymidylate Synthase Complexed with Nadph and Q-8 Antifolate
  96. 3irn: Trypanosoma Cruzi Dihydrofolate Reductase-thymidylate Synthase Complexed with Nadph and Cycloguanil
  97. 3irm: Trypanosoma Cruzi Dihydrofolate Reductase-thymidylate Synthase Complexed with Cycloguanil
  98. 3inv: Trypanosoma Cruzi Dihydrofolate Reductase-thymidylate Synthase Complexed with Nadph, Dump and C-448 Antifolate
  99. 3ia5: Moritella Profunda Dihydrofolate Reductase (dhfr)
  100. 3ia4: Moritella Profunda Dihydrofolate Reductase (dhfr) in Complex with Nadph and Methotrexate (mtx)
  101. 3i8a: Staphylococcus Aureus H30N, F98Y Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-(3-(2,5- Dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)
  102. 3hbb: Structures of Dihydrofolate Reductase-thymidylate Synthase of Trypanosoma Cruzi in The Folate-free State and in Complex with Two Antifolate Drugs, Trimetrexate and Methotrexate
  103. 1qzf: Crystal Structure of Dhfr-ts from Cryptosporidium Hominis
  104. 3gyf: Human Dhfr with Z-isomer in Orthorhombic Lattice
  105. 1ra1: Dihydrofolate Reductase Complexed with Nicotinamide Adenine Dinucleotide Phosphate (reduced Form)
  106. 1ra2: Dihydrofolate Reductase Complexed with Folate and Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  107. 1ra3: Dihydrofolate Reductase Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  108. 1ra8: Dihydrofolate Reductase Complexed with Folate and 2- Monophosphoadenosine 5'-diphosphoribose
  109. 1ra9: Dihydrofolate Reductase Complexed with Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  110. 1rb2: Dihydrofolate Reductase Complexed with Folate and Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  111. 1rb3: Dihydrofolate Reductase Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  112. 1rc4: Dihydrofolate Reductase Complexed with 5,10- Dideazatetrahydrofolate and Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  113. 1rd7: Dihydrofolate Reductase Complexed with Folate
  114. 1re7: Dihydrofolate Reductase Complexed with Folate
  115. 1rf7: Structure of Dihydrofolate Reductase Complexed with Dihydrofolate
  116. 1rg7: Dihydrofolate Reductase Complexed with Methotrexate
  117. 1rh3: Dihydrofolate Reductase Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (reduced Form)
  118. 3gi2: Human Dihydrofolate Reductase Q35K Mutant Inhibitor Complex
  119. 3ghw: Human Dihydrofolate Reductase Inhibitor Complex
  120. 3ghv: Human Dihydrofolate Reductase Q35K/N64F Double Mutant Inhibitor Complex
  121. 3ghc: Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-amino-4-oxo-5-substituted-6-thieno[2,3- D]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agenst
  122. 1rx1: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with Nicotinamide Adenine Dinucleotide Phosphate (reduced Form)
  123. 1rx2: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with with Folate and Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  124. 1rx3: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (reduced Form)
  125. 1rx4: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with 5,10- Dideazatetrahydrofolate and 2'-monophosphoadenosine 5'- Diphosphoribose
  126. 1rx5: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with 5,10- Dideazatetrahydrofolate
  127. 1rx6: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with 5,10- Dideazatetrahydrofolate and Nicotinamide Adenine Dinucleotide Phosphate (reduced Form)
  128. 1rx7: Structure of Dihydrofolate Reductase Complexed with Folate
  129. 1rx8: Dihydrofolate Reductase Complexed with Folate and 2'- Monophosphoadenosine 5'-diphosphoribose
  130. 1rx9: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  131. 1s3u: Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis Carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
  132. 1s3v: Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis Carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
  133. 1s3w: Structure Determination of Tetrahydroquinazoline Antifoaltes in Complex with Human and Pneumocystis Carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
  134. 1s3y: Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis Carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
  135. 3fyw: Staph. Aureus Dhfr Complexed with Nadph and Ar-101
  136. 3fyv: Staph. Aureus Dhfr Complexed with Nadph and Ar-102
  137. 3fy9: Staph. Aureus Dhfr F98Y Complexed with Ar-102
  138. 3fy8: Crystal Structure of Staph. Aureus Dhfr Complexed with Nadph and Ar-101
  139. 3fs6: Correlations of Inhibitor Kinetics for Pneumocystis Jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes
  140. 3frf: S. Aureus Dhfr Complexed with Nadph and Iclaprim
  141. 3fre: S. Aureus Dhfr Complexed with Nadph and Tmp
  142. 3frd: S. Aureus Dhfr Complexed with Nadph and Folate
  143. 3frb: S. Aureus F98Y Dhfr Complexed with Tmp
  144. 3fra: Staphylococcus Aureus F98Y Dhfr Complexed with Iclaprim
  145. 3fqz: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-4-phenylphenyl) But-1-ynyl]-6-methylpyrimidine
  146. 3fqv: Staphylococcus Aureus F98Y Mutant Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-4- Phenylphenyl)but-1-ynyl]-6-methylpyrimidine
  147. 3fqo: Staphylococcus Aureus F98Y Mutant Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(2,5- Dimethoxyphenyl)prop-1-ynyl]-6-ethylpyrimidine (UCP120B)
  148. 3fqf: Staphylococcus Aureus F98Y Mutant Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3,4,5- Trimethoxyphenyl)pent-1-ynyl]-6-methylpyrimidine (UCP115A)
  149. 3fqc: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3,4,5-trimethoxyphenyl) Pent-1-ynyl]-6-methylpyrimidine (UCP115A)
  150. 3fq0: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop- 1-ynyl)-6-ethylpyrimidine (UCP120B)
  151. 1sej: Crystal Structure of Dihydrofolate Reductase-thymidylate Synthase from Cryptosporidium Hominis Bound to 1843u89/nadph/dump
  152. 3fl9: Crystal Structure of B. Anthracis Dihydrofolate Reductase (dhfr) with Trimethoprim
  153. 3fl8: Crystal Structure of B. Anthracis Dihydrofolate Reductase (dhfr) with Rab1, a Tmp-dihydrophthalazine Derivative
  154. 3f91: Structural Data for Human Active Site Mutant Enzyme Complexes
  155. 3f8z: Human Dihydrofolate Reductase Structural Data with Active Site Mutant Enzyme Complexes
  156. 3f8y: Correlations of Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes
  157. 3f0x: Staphylococcus Aureus F98Y Mutant Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-5-(3, 5-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine
  158. 3f0v: Staphylococcus Aureus F98Y Mutant Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-5-(2, 6-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine
  159. 3f0u: Staphylococcus Aureus F98Y Mutant Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-5- Phenylphenyl)but-1-ynyl]-6-methylpyrimidine
  160. 3f0s: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-5-(3,5- Dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine
  161. 3f0q: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)but-1-ynyl]- 6-methylpyrimidine
  162. 3f0b: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-5-phenylphenyl) But-1-ynyl]-6-methylpyrimidine
  163. 1tdr: Expression, Characterization, and Crystallographic Analysis of Telluromethionyl Dihydrofolate Reductase
  164. 3eig: Crystal Structure of a Methotrexate-resistant Mutant of Human Dihydrofolate Reductase
  165. 3e0b: Bacillus Anthracis Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1- Ynyl)-6-ethylpyrimidine (UCP120B)
  166. 3drc: Investigation of The Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase by Site-directed Mutagenesis
  167. 1u70: Understanding The Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and LEU22ARG Variant Mouse and Human Dihydrofolate Reductase
  168. 1u71: Understanding The Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and LEU22ARG Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and Nadph
  169. 1u72: Understanding The Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and LEU22ARG Variant Mouse and Human Dihydrfolate Reductase Ternary Crystal Complexes with Methotrexate and Nadph
  170. 3dl6: Crystal Structure of The A287F/S290G Active Site Mutant of Ts-dhfr from Cryptosporidium Hominis
  171. 3dl5: Crystal Structure of The A287F Active Site Mutant of Ts- Dhfr from Cryptosporidium Hominis
  172. 3dga: Wild-type Plasmodium Falciparum Dihydrofolate Reductase- Thymidylate Synthase (pfdhfr-ts) Complexed with Rjf01302, Nadph, and Dump
  173. 3dg8: Quadruple Mutant (N51I+C59R+S108N+I164L) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts) Complexed with Rjf670, Nadph, and Dump
  174. 3dfr: Crystal Structures of Escherichia Coli and Lactobacillus Casei Dihydrofolate Reductase Refined at 1.7 Angstroms Resolution. I. General Features and Binding of Methotrexate
  175. 3dau: Crystal Structure of The Ternary Mtx Nadph Complex of Escherichia Coli Dihydrofolate Reductase
  176. 3dat: Crystal Structure of The Ternary Mtx Nadph Complex of Bacillus Anthracis Dihydrofolate Reductase
  177. 3d84: Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with Nadph and a Ternary Complex with The Potent and Selective Inhibitor 2.4-diamino-6-(-2'- Hydroxydibenz[b,f]azepin-5-yl)methylpteridine
  178. 3d80: Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with Nadph and a Ternary Complex Wtih The Potent and Selective Inhibitor 2,4-diamino-6-(2'- Hydroxydibenz[b,f]azepin-5-yl)methylpteridine
  179. 3cse: Candida Glabrata Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1- Ynyl)-6-ethylpyrimidine (UCP120B)
  180. 3clb: Structure of Bifunctional Tcdhfr-ts in Complex with Tmq
  181. 3cl9: Structure of Bifunctional Tcdhfr-ts in Complex with Mtx
  182. 3cd2: Ligand Induced Conformational Changes in The Crystal Structures of Pneumocystis Carinii Dihydrofolate Reductase Complexes with Folate and Nadp+
  183. 1vdr: Dihydrofolate Reductase
  184. 1vie: Structure of Dihydrofolate Reductase
  185. 1vif: Structure of Dihydrofolate Reductase
  186. 1vj3: Structural Studies on Bio-active Compounds. Crystal Structure and Molecular Modeling Studies on The Pneumocystis Carinii Dihydrofolate Reductase Cofactor Complex with Tab, a Highly Selective Antifolate.
  187. 2zza: Moritella Profunda Dihydrofolate Reductase Complex with Nadp+ and Folate
  188. 1yho: Solution Structure of Human Dihydrofolate Reductase Complexed with Trimethoprim and Nadph, 25 Structures
  189. 2w9t: Staphylococcus Aureus S1:dhfr
  190. 2w9s: Staphylococcus Aureus S1:dhfr in Complex with Trimethoprim
  191. 2w9h: Wild-type Staphylococcus Aureus Dhfr in Complex with Trimethoprim
  192. 2w9g: Wild-type Staphylococcus Aureus Dhfr in Complex with Nadph and Trimethoprim
  193. 1zdr: Dhfr from Bacillus Stearothermophilus
  194. 2w3w: Mycobacterium Avium Dihydrofolate Reductase Complexed with Nadph and a Lipophilic Antifolate Selective for M. Avium Dhfr, 6-((2,5-diethoxyphenyl)aminomethyl)-2,4-diamino-5- Methylpyrido(2,3-d)pyrimidine (sri-8686)
  195. 2w3v: Mycobacterium Avium Dihydrofolate Reductase Complexed with Nadph and Trimethoprim
  196. 2w3m: Human Dihydrofolate Reductase Complexed with Nadph and Folate
  197. 2w3b: Human Dihydrofolate Reductase Complexed with Nadph and a Lipophilic Antifolate Selective for Mycobacterium Avium Dhfr, 6-((2,5-diethoxyphenyl)aminomethyl)-2,4-diamino-5- Methylpyrido(2,3-d)pyrimidine (sri-8686)
  198. 2w3a: Human Dihydrofolate Reductase Complexed with Nadph and Trimethoprim
  199. 2ano: Crystal Structure of E.coli Dihydrofolate Reductase in Complex with Nadph and The Inhibitor Ms-sh08-17
  200. 2anq: Crystal Structure of E.coli Dhfr in Complex with Nadph and The Inhibitor Compound 10a.
  201. 2rk2: Dhfr R-67 Complexed with Nadp
  202. 2rk1: Dhfr R67 Complexed with Nadp and Dihydrofolate
  203. 2rh2: High Resolution Dhfr R-67
  204. 2bl9: X-ray Crystal Structure of Plasmodium Vivax Dihydrofolate Reductase in Complex with Pyrimethamine and Its Derivative
  205. 2bla: Sp21 Double Mutant P. Vivax Dihydrofolate Reductase in Complex with Pyrimethamine
  206. 2blb: X-ray Crystal Structure of Plasmodium Vivax Dihydrofolate Reductase in Complex with Pyrimethamine and Its Derivative
  207. 2blc: Sp21 Double Mutant P. Vivax Dihydrofolate Reductase in Complex with Des-chloropyrimethamine
  208. 2c2s: Human Dihydrofolate Reductase Complexed with Nadph and 2,4- Diamino-5-(1-o-carboranylmethyl)-6-methylpyrimidine, a Novel Boron Containing, Nonclassical Antifolate
  209. 2c2t: Human Dihydrofolate Reductase Complexed with Nadph and 2,4- Diamino-5-((7,8-dicarbaundecaboran-7-yl)methyl)-6- Methylpyrimidine, a Novel Boron Containing, Nonclassical Antifolate
  210. 2qk8: Crystal Structure of The Anthrax Drug Target, Bacillus Anthracis Dihydrofolate Reductase
  211. 2cd2: Ligand Induced Conformational Changes in The Crystal Structures of Pneumocystis Carinii Dihydrofolate Reductase Complexes with Folate and Nadp+
  212. 2cig: Dihydrofolate Reductase from Mycobacterium Tuberculosis Inhibited by The Acyclic 4r Isomer of Inh-nadp a Derivative of The Prodrug Isoniazid.
  213. 2d0k: Methionine-free Mutant of Escherichia Coli Dihydrofolate Reductase
  214. 2p4t: Structure of The Q67H Mutant of R67 Dihydrofolate Reductase- Nadp+ Complex Reveals a Novel Cofactor Binding Mode
  215. 2dhf: Crystal Structures of Recombinant Human Dihydrofolate Reductase Complexed with Folate and 5-deazofolate
  216. 2oip: Crystal Structure of The S290G Active Site Mutant of Ts- Dhfr from Cryptosporidium Hominis
  217. 2drc: Investigation of The Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase by Site-directed Mutagenesis
  218. 6aoi: Crystal Structure of Toxoplasma Gondii Ts-dhfr Complexed with Nadph, Dump, Pddf, and 5-(4-phenylpiperazin-1-yl)-6-propylpyrimidine-2,4- Diamine (trc-2528)
  219. 6aoh: Crystal Structure of Toxoplasma Gondii Ts-dhfr Complexed with Nadph, Dump, Pddf, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1- Yl)pyrimidine-2,4-diamine (trc-2533)
  220. 6aog: Crystal Structure of Toxoplasma Gondii Ts-dhfr Complexed with Nadph, Dump, Pddf, and 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine (pyrimethamine)
  221. 6a7e: Human Dihydrofolate Reductase Complexed with Nadph and Bt2
  222. 6a7c: Human Dihydrofolate Reductase Complexed with Nadph and Bt1
  223. 2fzh: New Insights into Dihydrofolate Reductase Interactions: Analysis of Pneumocystis Carinii and Mouse Dhfr Complexes with Nadph and Two Highly Potent Trimethoprim Derivatives
  224. 2fzi: New Insights into Dhfr Interactions: Analysis of Pneumocystis Carinii and Mouse Dhfr Complexes with Nadph and Two Highly Potent Trimethoprim Derivatives
  225. 2fzj: New Insights into Dhfr Interactions: Analysis of Pneumocystis Carinii and Mouse Dhfr Complexes with Nadph and Two Highly Potent Trimethoprim Derivatives
  226. 5z6m: High-pressure Crystal Structure Analysis of M20 Loop Closed Dhfr at 800 Mpa
  227. 5z6l: High-pressure Crystal Structure Analysis of M20 Loop Closed Dhfr at 650 Mpa
  228. 5z6k: High-pressure Crystal Structure Analysis of M20 Loop Closed Dhfr at 400 Mpa
  229. 5z6j: High-pressure Crystal Structure Analysis of M20 Loop Closed Dhfr at 220 Mpa
  230. 5z6f: High-pressure Crystal Structure Analysis of Dhfr(0.1 Mpa)
  231. 2gqv: High-resolution Structure of a Plasmid-encoded Dihydrofolate Reductase: Pentagonal Network of Water Molecules in The D2-symmetric Active Site
  232. 2h2q: Crystal Structure of Trypanosoma Cruzi Dihydrofolate Reductase-thymidylate Synthase
  233. 2hm9: Solution Structure of Dihydrofolate Reductase Complexed with Trimethoprim, 33 Structures
  234. 2hqp: Solution Structure of L.casei Dihydrofolate Reductase Complexed with Nadph, 32 Structures
  235. 2inq: Neutron Crystal Structure of Escherichia Coli Dihydrofolate Reductase Bound to The Anti-cancer Drug, Methotrexate
  236. 2ith: Nmr Structure of Haloferax Volcanii Dhfr
  237. 6vvb: Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with 6- Methyl-5-(4-phenylthiazol-2-yl)-2- (trifluoromethyl)nicotinic Acid (fragment 10)
  238. 6vv9: Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with Jeb300
  239. 6vv8: Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with Jeb285
  240. 6vv7: Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with Jeb136
  241. 6vv6: Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with Jeb113
  242. 6vsg: Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with 4- (trifluoromethyl)benzene-1,2-diamine(fragment 17)
  243. 6vsf: Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with 4- (3,4-dihydro-2h-benzo[b][1,4]dioxepin-7-yl)-4-oxobutanoic Acid(fragment 16)
  244. 6vse: Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with 3- (phenoxymethyl)benzoic Acid(fragment 14)
  245. 6vsd: Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with 3- ((thiophen-2-ylthio)methyl)benzoic Acid (fragment 13)
  246. 6vs9: Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with 3- (piperidin-1-ylmethyl)benzoic Acid(fragment 11)
  247. 6vs8: Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with Ethyl 2-methyl Thiazole-4-carboxylate(fragment 3)
  248. 6vs6: Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with 3- (furan-2-yl)-1-methyl-1h-pyrazole-5-carboxylic Acid (fragment 2)
  249. 6vs5: Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with 5- Methyl-1-phenyl-1h-pyrazole-4-carboxylic Acid (fragment 1)
  250. 2jyb: Binary Hvdhfr1:folate Complex
  251. 6vcj: Crystal Structure of Hsdhfr in Complex with Nadp+, Dap, and R-naproxen
  252. 6uww: Crystal Structure of Dihydrofolate Reductase from Mycobacterium Ulcerans with P218 Inhibitor
  253. 6uwq: Crystal Structure of Dihydrofolate Reductase from Mycobacterium Ulcerans with Sddc-0001565 Inhibitor
  254. 3kfy: Dynamic Switching and Partial Occupancies of a Small Molecule Inhibitor Complex of Dhfr
  255. 3och: Chemically Self-assembled Antibody Nanorings (csans): Design and Characterization of an Anti-cd3 Igm Biomimetic
  256. 6prd: S. Aureus Dihydrofolate Reductase Co-crystallized with Para- Methoxyphenyl-dimethyoxydihydropthalazine Inhibitor and Nadp(h)
  257. 6prb: S. Aureus Dihydrofolate Reductase Co-crystallized with Cyclopropyl- Dimethyoxydihydropthalazine Inhibitor and Nadp(h)
  258. 6pra: S. Aureus Dihydrofolate Reductase with Nadp(h) and Empty Folate Pocket
  259. 6pr9: S. Aureus Dihydrofolate Reductase Co-crystallized with 1-ethylpropyl- Dihydropthalazine Inhibitor and Nadp(h)
  260. 6pr8: S. Aureus Dihydrofoate Reductase Co-crystallized with 3,5- Dimethylphenyl-dihydropthalazine Inhibitor and Nadp(h)
  261. 6pr7: S. Aureus Dihydrofolate Reductase Co-crystallized with Benzyl- Dihydropthalazine Inhibitor and Nadp(h)
  262. 6pr6: S. Aureus Dihydrofolate Reductase Co-crystallized with Para-tolyl- Dihydropthalazine Inhibitor and Nadp(h)
  263. 3l3r: Structural, Computational and Kinetic Data for Antifolate Interactions against Pneumocystis Jirovecii, Pneumocystis Carinii and Human Dihydrofolate Reductase and Their Active Site Mutants
  264. 3nxx: Preferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for The E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro-2,3-d]pyrimidines as Ternary Complexes with Nadph and Human Dihydrofolate Reductase
  265. 3nxy: Preferential Selection of Isomer Binding from Chiral Mixtures: Alernate Binding Modes Observed Fro The E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes with Nadph and Human Dihydrofolate Reductase
  266. 3nz6: Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and a Series of Five Potent 5-(omega-carboxy(alkyloxy) Pyrido[2,3-d]pyrimidine Derivatives
  267. 3nz9: Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and a Series of Five Potent 5-(omega-carboxy(alkyloxy) Pyrido[2,3-d]pyrimidine Derivatives
  268. 3nza: Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and a Series of Five Potent 5-(omega-carboxy(alkyloxy) Pyrido[2,3-d]pyrimidine Derivatives
  269. 3nzb: Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and a Series of Potent 5-(omega-carboxyl(alkyloxy) Pyrido[2,-d]pyrimidine Derivatives
  270. 3nzc: Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and a Series of Five Potent 5-(omega-carboxy(alkyloxy) Pyrido[2,3-d]pyridine Derivativea
  271. 3nzd: Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and a Series of Five 5-(omega-carboxy(alkyloxy(pyrido[2,3- D]pyrimidine Derivatives
  272. 3q1h: Crystal Structure of Dihydrofolate Reductase from Yersinia Pestis
  273. 2l28: Solution Structure of Lactobacillus Casei Dihydrofolate Reductase Apo- Form, 25 Conformers
  274. 3ql0: Crystal Structure of N23PP/S148A Mutant of E. Coli Dihydrofolate Reductase
  275. 3ql3: Re-refined Coordinates for Pdb Entry 1rx2
  276. 3ntz: Design, Synthesis, Biological Evaluation and X-ray Crystal Structures of Novel Classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors
  277. 3nu0: Design, Synthesis, Biological Evaluation and X-ray Crystal Structure of Novel Classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors
  278. 3qfx: Trypanosoma Brucei Dihydrofolate Reductase Pyrimethamine Complex
  279. 3qg2: Plasmodium Falciparum Dhfr-ts Qradruple Mutant (N51I+C59R+S108N+I164L, V1/s) Pyrimethamine Complex
  280. 3qgt: Crystal Structure of Wild-type Pfdhfr-ts Complexed with Nadph, Dump and Pyrimethamine
  281. 3rg9: Trypanosoma Brucei Dihydrofolate Reductase (tbdhfr) in Complex with Wr99210
  282. 3oaf: Structural and Kinetic Data for Antifolate Interactions against Pneumocystis Jirovecii, Pneumocystis Carinii and Human Dihydrofolate Reductase and Thier Active Site Mutants
  283. 3sqy: S. Aureus Dihydrofolate Reductase Complexed with Novel 7-aryl-2,4- Diaminoquinazolines
  284. 3sr5: S. Aureus Dihydrofolate Reductase Complexed with Novel 7-aryl-2,4- Diaminoquinazolines
  285. 3srq: S. Aureus Dihydrofolate Reductase Complexed with Novel 7-aryl-2,4- Diaminoquinazolines
  286. 3srr: S. Aureus Dihydrofolate Reductase Complexed with Novel 7-aryl-2,4- Diaminoquinazolines
  287. 3srs: S. Aureus Dihydrofolate Reductase Complexed with Novel 7-aryl-2,4- Diaminoquinazolines
  288. 3sru: S. Aureus Dihydrofolate Reductase Complexed with Novel 7-aryl-2,4- Diaminoquinazolines
  289. 3srw: S. Aureus Dihydrofolate Reductase Complexed with Novel 7-aryl-2,4- Diaminoquinazolines
  290. 3n0h: Hdhfr Double Mutant Q35S/N64F Trimethoprim Binary Complex
  291. 3s3v: Human Dihydrofolate Reductase Q35K/N64F Double Mutant Binary Complex with Trimethoprim
  292. 3s7a: Human Dihydrofolate Reductase Binary Complex with Pt684
  293. 3sfm: Novel Crystallization Conditions for Tandem Variant R67 Dhfr Yields Wild-type Crystal Structure
  294. 3tq8: Structure of The Dihydrofolate Reductase (fola) from Coxiella Burnetii in Complex with Trimethoprim
  295. 3tq9: Structure of The Dihydrofolate Reductase (fola) from Coxiella Burnetii in Complex with Methotrexate
  296. 3tqa: Structure of The Dihydrofolate Reductase (fola) from Coxiella Burnetii in Complex with Nadph
  297. 3tqb: Structure of The Dihydrofolate Reductase (fola) from Coxiella Burnetii in Complex with Folate
  298. 2lf1: Solution Structure of L. Casei Dihydrofolate Reductase Complexed with Nadph, 30 Structures
  299. 3qyl: Sensitivity of Receptor Internal Motions to Ligand Binding Affinity and Kinetic Off-rate
  300. 3qyo: Sensitivity of Receptor Internal Motions to Ligand Binding Affinity and Kinetic Off-rate
  301. 3r33: Evidence for Dynamic Motion in Proteins as a Mechanism for Ligand Dissociation
  302. 6pbo: Staphylococcus Aureus Dihydrofolate Reductase in Complex with Nadph and Ucp1232
  303. 6p9z: Staphylococcus Aureus Dihydrofolate Reductase in Complex with Nadph and Methotrexate
  304. 3sgy: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 6-ethyl-5-[(3s)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1- Yl]pyrimidine-2,4-diamine (ucp1006)
  305. 3sh2: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 6-ethyl-5-(3-(4-methoxybiphenyl-3-yl)prop-1-ynyl)pyrimidine-2,4- Diamine (UCP120J)
  306. 3td8: Structural Analysis of Pneumocystis Carinii Dihydrofolate Reductase Complex with Nadph and 2,4-diamino-5-methyl-6-[2'-(4-carboxy-1- Pentynyl)-5'-methoxybenzyl]pyrido[2,3-d]pyrimidine
  307. 6ny0: Crystal Structure of Trimethoprim-resistant Type II Dihydrofolate Reductase in Complex with a Bisbenzimidazole Inhibitor
  308. 6nxz: Crystal Structure of Trimethoprim-resistant Type II Dihydrofolate Reductase in Complex with a Bisbenzimidazole Inhibitor
  309. 6nni: Structure of Closed State of Dihydrofolate Reductase from Mycobacterium Tuberculosis in Complex with Nadph and Pyrimethamine
  310. 6nnh: Structure of Closed State of Dihydrofolate Reductase from Mycobacterium Tuberculosis in Complex with Nadph and Cycloguanil
  311. 6nne: Crystal Structure of Dihydrofolate Reductase from Mycobacterium Tuberculosis in Complex with Diaverdine
  312. 6nnd: Structure of Dihydrofolate Reductase from Mycobacterium Tuberculosis in Complex with Nadph and Dihydrofolate
  313. 6nnc: Structure of Dihydrofolate Reductase from Mycobacterium Tuberculosis in Complex with Nadph and Pemetrexed
  314. 6nd2: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 6-ethyl-5-[(3r)-3-[2-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1- Yl]pyrimidine-2,4-diamine (ucp1063)
  315. 6n1t: Toxoplasma Gondii Ts-dhfr in Complex with Selective Inhibitor 3
  316. 6n1s: Toxoplasma Gondii Ts-dhfr in Complex with Selective Inhibitor 29
  317. 3s9u: Bacillus Anthracis Dihydrofolate Reductase Bound to Propargyl-linked Tmp Analog, UCP120J
  318. 3sa1: Bacuills Anthracis Dihydrofolate Reductase Bound Propargyl-linked Tmp Analog, Ucp1021
  319. 3sa2: Bacuills Anthracis Dihydrofolate Reductase Bound Propargyl-linked Tmp Analog, Ucp1014
  320. 3sai: Bacuills Anthracis Dihydrofolate Reductase Bound to Propargyl-linked Tmp Analog, Ucp1015
  321. 6mth: E. Coli Dhfr Complex Modeled with Three Ligand States
  322. 6mt8: E. Coli Dhfr Complex Modeled with Two Ligand States
  323. 6mr9: E. Coli Dhfr Complex with a Reaction Intermediate
  324. 3um5: Double Mutant (A16V+S108T) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts-t9/94) Complexed with Pyrimethamine, Nadph, and Dump
  325. 3um6: Double Mutant (A16V+S108T) Plasmodium Falciparum Dhfr-ts (t9/94) Complexed with Cycloguanil, Nadph and Dump
  326. 3um8: Wild-type Plasmodium Falciparum Dhfr-ts Complexed with Cycloguanil and Nadph
  327. 4ddr: Human Dihydrofolate Reductase Complexed with Nadph and P218
  328. 4dp3: Quadruple Mutant (N51I+C59R+S108N+I164L) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts) Complexed with P218 and Nadph
  329. 4dpd: Wild Type Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts), Dhf Complex, Nadp+, Dump
  330. 4dph: Quadruple Mutant (N51I+C59R+S108N+I164L) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts) Complexed with P65 and Nadph
  331. 4elb: Structure-activity Relationship Guides Enantiomeric Preference among Potent Inhibitors of B. Anthracis Dihydrofolate Reductase
  332. 4ele: Structure-activity Relationship Guides Enantiomeric Preference among Potent Inhibitors of B. Anthracis Dihydrofolate Reductase
  333. 4elf: Structure-activity Relationship Guides Enantiomeric Preference among Potent Inhibitors of B. Anthracis Dihydrofolate Reductase
  334. 4elg: Structure-activity Relationship Guides Enantiomeric Preference among Potent Inhibitors of B. Anthracis Dihydrofolate Reductase
  335. 4elh: Structure-activity Relationship Guides Enantiomeric Preference among Potent Inhibitors of B. Anthracis Dihydrofolate Reductase
  336. 4fgg: S. Aureus Dihydrofolate Reductase Co-crystallized with Propyl-dap Isobutenyl-dihydrophthalazine Inhibitor
  337. 4fgh: S. Aureus Dihydrofolate Reductase Co-crystallized with Ethyl-dap Isobutenyl-dihydrophthalazine Inhibitor
  338. 3vco: Schistosoma Mansoni Dihydrofolate Reductase
  339. 4h95: Candida Albicans Dihydrofolate Reductase Complexed with Nadph and 6- Ethyl-5-{3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1- Yl}pyrimidine-2,4-diamine (ucp1006)
  340. 4h96: Candida Albicans Dihydrofolate Reductase Complexed with Nadph and 5- {3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1- Yl}-6-ethylpyrimidine-2,4-diamine (ucp1018)
  341. 4h97: Candida Albicans Dihydrofolate Reductase Complexed with Nadph and 5- {3-[3-methoxy-5-(4-methylphenyl)phenyl]but-1-yn-1-yl}-6- Methylpyrimidine-2,4-diamine (UCP111D4M)
  342. 4h98: Candida Glabrata Dihydrofolate Reductase Complexed with Nadph and 5- {3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1- Yl}-6-ethylpyrimidine-2,4-diamine (ucp1018)
  343. 4eig: Ca1698 Camel Antibody Fragment in Complex with Dhfr
  344. 4eiz: Structure of Nb113 Bound to Apodhfr
  345. 4ej1: Binding of Nb113 Camelid Antibody Fragment with The Binary Dhfr:folate Complex
  346. 6rul: Crystal Structure of Gfp-lama-f98 - a Gfp Enhancer Nanobody with Cpdhfr Insertion and Tmp and Nadph
  347. 6rum: Crystal Structure of Gfp-lama-g97 - a Gfp Enhancer Nanobody with Cpdhfr Insertion and Tmp and Nadph
  348. 4fhb: Enhancing Dhfr Catalysis by Binding of an Allosteric Regulator Nanobody (nb179)
  349. 4g8z: Pcdhfr K37S/F69N Double Mutant Tmp Nadph Ternary Complex
  350. 4gh8: Crystal Structure of a 'humanized' E. Coli Dihydrofolate Reductase
  351. 4ixe: Pcdhfr-nadph-270
  352. 4ixf: Pcdhfr-269 F69N Variant
  353. 4ixg: PCDHFR-268-K37S-N69F Variant
  354. 6e4e: Crystal Structure of Dihydrofolate Reductase from Staphylococcus Aureus Mw2 Bound to Nadp and P218
  355. 6de4: Homo Sapiens Dihydrofolate Reductase Complexed with Beta-nadph and 3'- [(2r)-4-(2,4-diamino-6-ethylphenyl)but-3-yn-2-yl]-5'-methoxy-[1,1'- Biphenyl]-4-carboxylic Acid
  356. 6ddw: Mycobacterium Tuberculosis Dihydrofolate Reductase Complexed with Beta-nadph and N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl) Methyl]amino}-2-hydroxybenzene-1-carbonyl)-l-glutamic Acid
  357. 6dds: Mycobacterium Tuberculosis Dihydrofolate Reductase Complexed with Beta-nadph and 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop- 2-ynyl]-5-methoxy-phenyl]benzoic Acid
  358. 6ddp: Mycobacterium Tuberculosis Dihydrofolate Reductase Complexed with Beta-nadph and 3'-[(2r)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3- Yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic Acid
  359. 6dav: Crystal Structure of Human Dhfr Complexed with Nadp and N10FORMYLTETRAHYDROFOLATE
  360. 6cyv: E. Coli Dhfr Ternary Complex with Nadp and Dihydrofolate
  361. 6cxm: Crystal Structure of a Dihydrofolate Reductase from Mycobacterium Smegmatis in Complex with Nadp and P218
  362. 6cxk: E. Coli Dhfr Substrate Complex with Dihydrofolate
  363. 6cw7: E. Coli Dhfr Product Complex with (6s)-5,6,7,8-tetrahydrofolate
  364. 6cqa: E. Coli Dhfr Complex with Inhibitor Ampqd
  365. 4eck: Crystal Structure of The Toxoplasma Gondii Ts-dhfr
  366. 4eil: Crystal Structure of The Loop Truncated Toxoplasma Gondii Ts-dhfr
  367. 4g95: Hdhfr-oag Binary Complex
  368. 4hoe: Candida Albicans Dihydrofolate Reductase Complexed with Nadph and 5- [3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2, 4-diamine (UCP111E)
  369. 4hof: Candida Albicans Dihydrofolate Reductase Complexed with Nadph and 5- [3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4- Diamine (UCP111H)
  370. 4i13: Nanobody Ca1697 Binding to The Dhfr.folate Binary Complex
  371. 4i1n: R104A-CA1697 Nanobody Binding to The Binary Dhfr.folate Complex
  372. 4kak: Crystal Structure of Human Dihydrofolate Reductase Complexed with Nadph and 6-ethyl-5-[(3s)-3-[3-methoxy-5-(pyridine-4-yl)phenyl]but-1- Yn-1-yl]pyrimidine-2,4-diamine (ucp1006)
  373. 4kbn: Human Dihydrofolate Reductase Complexed with Nadph and 5-{3-[3-(3,5- Pyrimidine)]-phenyl-prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4diamine
  374. 4kd7: Human Dihydrofolate Reductase Complexed with Nadph and 5-{3-[3- Methoxy-5(pyridine-4-yl)phenyl]prop-1-yn-1-yl}-6-ethyl-pyrimidine-2, 4-diamine
  375. 4keb: Human Dihydrofolate Reductase Complexed with Nadph and 5-{3-[3- Methoxy-5-(isoquin-5-yl)phenyl]but-1-yn-1-yl}6-ethylpyrimidine-2,4- Diamine
  376. 4kfj: Human Dihydrofolate Reductase Complexed with Nadph and 5-{3-[3- Methoxy-5-(isoquin-5-yl)phenyl]prop-1-yn-1-yl}6-ethylprimidine-2,4- Diamine
  377. 4kjj: Cryogenic Wt Dhfr
  378. 4kjk: Room Temperature Wt Dhfr
  379. 4kjl: Room Temperature N23PPS148A Dhfr
  380. 4kl9: Crystal Structure of Dihydrofolate Reductase from Mycobacterium Tuberculosis in The Space Group C2
  381. 4klx: Crystal Structure of Dihydrofolate Reductase from Mycobacterium Tuberculosis in an Open Conformation.
  382. 4km0: Crystal Structure of Dihydrofolate Reductase from Mycobacterium Tuberculosis in Complex with Pyrimethamine
  383. 4km2: Crystal Structure of Dihydrofolate Reductase from Mycobacterium Tuberculosis in an Open Conformation in Complex with Trimethoprim
  384. 4kne: Crystal Structure of Dihydrofolate Reductase from Mycobacterium Tuberculosis in Complex with Cycloguanil
  385. 4ky4: Crystal Structure of Non-classical Ts Inhibitor 2 in Complex with Toxoplasma Gondii Ts-dhfr
  386. 4ky8: Crystal Structure of Ts-dhfr from Cryptosporidium Hominis in Complex with Nadph, Methotrexate, Fdump and 4-((2-amino-6-methyl-4-oxo-4,7- Dihydro-3h-pyrrolo[2,3-d]pyrimidin-5-yl)thio)-2-chlorophenyl)-l- Glutamic Acid
  387. 4kya: Crystal Structure of Non-classical Ts Inhibitor 3 in Complex with Toxoplasma Gondii Ts-dhfr
  388. 4lae: Structure-based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines
  389. 4lag: Structure-based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines
  390. 4lah: Structure-based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines
  391. 4lek: Structure-based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines
  392. 4m2x: Mycobacterium Tuberculosis Dihydrofolate Reductase Complexed with Trimetrexate (tmq)
  393. 4m6j: Crystal Structure of Human Dihydrofolate Reductase (dhfr) Bound to Nadph
  394. 4m6k: Crystal Structure of Human Dihydrofolate Reductase (dhfr) Bound to Nadp+ and Folate
  395. 4m6l: Crystal Structure of Human Dihydrofolate Reductase (dhfr) Bound to Nadp+ and 5,10-dideazatetrahydrofolic Acid
  396. 4m7u: Dihydrofolate Reductase from Enterococcus Faecalis Complexed with Nadp(h)
  397. 4m7v: Dihydrofolate Reductase from Enterococcus Faecalis Complexed with Nadp(h)and Rab-propyl
  398. 4nx6: Single Room Temperature Model of Dhfr
  399. 4nx7: Single Cryogenic Temperature Model of Dhfr
  400. 4p3q: Room-temperature Wt Dhfr, Time-averaged Ensemble
  401. 4p3r: Cryogenic Wt Dhfr, Time-averaged Ensemble
  402. 4p66: Electrostatics of Active Site Microenvironments of E. Coli Dhfr
  403. 4p68: Electrostatics of Active Site Microenvironments for E. Coli Dhfr
  404. 4pth: Ensemble Model for Escherichia Coli Dihydrofolate Reductase at 100k
  405. 4ptj: Ensemble Model for Escherichia Coli Dihydrofolate Reductase at 277k
  406. 4q0d: Crystal Structure of Ts-dhfr from Cryptosporidium Hominis in Complex with Nadph, Fdump, Methotrexate and 2-amino-4-oxo-4,7-dihydro- Pyrrolo[2,3-d]pyrimidine-methyl-phenyl-l-glutamic Acid.
  407. 4q0e: Crystal Structure of Ts-dhfr from Cryptosporidium Hominis in Complex with Nadph, Fdump and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3- D]pyrimidine-methyl-phenyl-l-glutamic Acid.
  408. 4qi9: Crystal Structure of Dihydrofolate Reductase from Yersinia Pestis Complexed with Methotrexate
  409. 5w3q: L28F E.coli Dhfr in Complex with Nadph
  410. 4rgc: 277k Crystal Structure of Escherichia Coli Dihydrofolate Reductase
  411. 4qle: Crystal Structure of I14A Dhfr Mutant Complexed with Folate and Nadp+
  412. 4qlf: Crystal Structure of I14G Dhfr Mutant Complexed with Folate and Nadp+
  413. 4qlg: Crystal Structure of I14V Dhfr Mutant Complexed with Folate and Nadp+
  414. 4or7: Klebsiella Pneumoniae Dihydrofolate Reductase Complexed with Nadph and 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4- Diamine
  415. 4osg: Klebsiella Pneumoniae Complexed with Nadph and 6-ethyl-5-[(3r)-3-[3- Methoxyl-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (ucp1006)
  416. 5ujx: Crystal Structure of Dhfr in 20% Isopropanol
  417. 5ujf: Crystal Structure of Mycobacterium Tuberculosis Dihydrofolate Reductase Bound P218 Inhibitor
  418. 5uip: Structure of Dhfr with Bound Dap, P-abg and Nadp
  419. 5uio: Structure of Dhfr with Bound Dap, P-abg and Nadp
  420. 5uii: Structure of Dhfr with Bound Buformin and Nadp
  421. 5uih: Structure of Dhfr with Bound Phenformin and Nadp
  422. 5u27: Crystal Structure of Mycobacterium Tuberculosis Dihydrofolate Reductase Bound to Nadp and P65 Inhibitor
  423. 5u26: Crystal Structure of Mycobacterium Tuberculosis Dihydrofolate Reductase Bound to Nadp and P218 Inhibitor
  424. 5t0l: Crystal Structure of Toxoplasma Gondii Ts-dhfr Complexed with Nadph, Dump, Pddf and 5-(4-(3,4-dichlorophenyl)piperazin-1-yl)pyrimidine-2, 4-diamine (trc-15)
  425. 5jg0: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Beta- Nadph and Ucp1191
  426. 5ja3: Mycobacterium Tuberculosis Dihydrofolate Reductase Complexed with Beta- Nadph and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1- Yl)-4'-methoxy-[1,1'-b Iphenyl]-4-carboxylic Acid (ucp1106)
  427. 5ist: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Beta- Nadph, Cyclic Alpha-nadph Anomer and 3'-(3-(2,4-diamino-6- Ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4- Carboxylic Acid (ucp1106)
  428. 5isq: Staphylococcus Aureus H30N, F98Y Dihydrofolate Reductase Mutant Complexed with Beta-nadph and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5- Yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic Acid (ucp1106)
  429. 5isp: Staphylococcus Aureus F98Y Dihydrofolate Reductase Mutant Complexed with Beta-nadph and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2- Yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic Acid (ucp1106)
  430. 5hve: 5-methyl-6-(3'-trifluromethoxyphenylthio)[2,3-d]pyrimidine 2,4-diamine
  431. 5hvb: 5-methyl-6-(1-naphthylthio)thieno[2,3-d]pyrimidine 2,4-diamine
  432. 5hui: 6-substituted Pyrido[3,2-d]pyrimidine--6-4'-trifluoromethoxyphenyl)
  433. 5ht5: 6-substituted Pyrrolo[2,3-d]pyrimidine 6-thieno-(4-methoxyphenyl)
  434. 5ht4: 6-substituted Pyrrolo[2,3-d]pyrimidine 6-thieno-(4-methoxyphenyl)
  435. 5hsu: Fluorine Substituted 5-methyl-6-(2',4'-difluoromethoxyphenythio) Thieno[2,3-d]pyrimidine-2,4-diamine
  436. 5hsr: Fluorine Substituted 5-methyl-6-(3',4'-difluoromethoxyphenythio) Thieno[2,3-d]pyrimidine-2,4-diamine
  437. 5hqz: Fluorine Substituted 5-methyl-6-(4'-trifluoromethoxyphenythio) Thieno[2,3-d]pyrimidine-2,4-diamine
  438. 5hqy: Human Dihydrofolate Reductase Complex with Nadph and 5-methyl-6-(2', 3',4'-trifluorophenylthio)thieno[2,3-d]pyrimidine-2,4-diamine
  439. 5hpb: Human Dihydrofolate Reductase Complex with Nadph and 5-methyl-6- (phenylthio-4'trifluoromethyl)thieno[2,3-d]pyrimidine-2,4-diamine
  440. 5hi6: The High Resolution Structure of Dihydrofolate Reductase from Yersinia Pestis Complex with Methotrexate as Closed Form
  441. 5hf2: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Cyclized Alpha-nadph Anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop- 2-yn-1-yl)-5'-methoxy-[1,1'-biphenyl]-4-carboxylic Acid (ucp1175)
  442. 5hf0: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Beta- Nadph, Cyclic Alpha-nadph Anomer and 3'-(3-(2,4-diamino-6- Ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4- Carboxylic Acid (ucp1106)
  443. 5fda: The High Resolution Structure of Apo Form Dihydrofolate Reductase from Yersinia Pestis at 1.55 a
  444. 5eaj: Crystal Structure of Dhfr in 0% Isopropanol
  445. 5e8q: Crystal Structure of Dhfr in 20% Isopropanol
  446. 5ccc: Wild-type E.coli Dihydrofolate Reductase Complexed with 5,10- Dideazatetrahydrofolate and Oxidized Nicotinamide Adenine Dinucleotide Phosphate
  447. 5cc9: L28F E.coli Dihydrofolate Reductase Complexed with 5,10- Dideazatetrahydrofolate and Oxidized Nicotinamide Adenine Dinucleotide Phosphate
  448. 4q67: Staphylococcus Aureus F98Y Mutant Dihydrofolate Reductase Complexed with Nadph
  449. 4q6a: Staphylococcus Aureus V31L, F98Y Mutant Dihydrofolate Reductase Complexed with Nadph
  450. 4d3d: Structure of Imine Reductase Bcsired from Bacillus Cereus BAG3X2
  451. 4d3f: Bcsired from Bacillus Cereus in Complex with Nadph
  452. 4d3s: Imine Reductase from Nocardiopsis Halophila
  453. 4pdj: Neutron Crystal Structure of E.coli Dihydrofolate Reductase Complexed with Folate and Nadp+
  454. 4qhv: Crystal Structure of Human Dihydrofolate Reductase as Complex with Pyridopyrimidine 22 (n~6~-methyl-n~6~-[4-(propan-2-yl) Phenyl]pyrido[2,3-d]pyrimidine-2,4,6-triamine)
  455. 4qjc: Human Dihydrofolate Reductase Ternary Complex with Nadph and Inhibitor 26 (n~6~-methyl-n~6~-(3,4,5-trifluorophenyl)pyrido[2,3-d]pyrimidine- 2,4,6-triamine)
  456. 4qjz: Pneumocystis Carinii Dihydrofolate Reductase Ternary Complex with Nadph and The Inhibitor 24, (n~6~-methyl-n~6~-(naphthalen-1-yl) Pyrido[2,3-d]pyrimidine-2,4,6-triamine)
  457. 4tu5: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 6-ethyl-5-[(3s)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1- Yl]pyrimidine-2,4-diamine (ucp1062)
  458. 4x5f: Ecdhfr Complexed with Folate and Nadp+ at 0.1 Mpa
  459. 4x5g: Ecdhfr Complexed with Folate and Nadp+ at 270 Mpa
  460. 4x5h: Ecdhfr Complexed with Folate and Nadp+ at 500 Mpa
  461. 4x5i: Ecdhfr Complexed with Folate and Nadp+ at 660 Mpa
  462. 4x5j: Ecdhfr Complexed with Folate and Nadp+ at 750 Mpa
  463. 4xe6: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 6-ethyl-5-[(3r)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1- Yl]pyrimidine-2,4-diamine (ucp1061)
  464. 4xec: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 6-ethyl-5-[(3r)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1- Yl]pyrimidine-2,4-diamine (ucp1061)
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