EC 1.1.1.146 - 11β- hydroxysteroid:NADP ⁺ 11- oxidoreductase (11\xCE\xB2- hydroxysteroid dehydrogenase)

3D structures of EC 1.1.1.146 - 11\xCE\xB2-hydroxysteroid dehydrogenase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 3hfg: Crystal Structure of Human 11-beta-hydroxysteroid- Dehydrogenase Bound to an Sulfonyl-piperazine Inhibitor
2. 3h6k: Crystal Structure of Human 11-beta-hydroxysteroid- Dehydrogenase Bound to an Ortho-chlro-sulfonyl-piperazine Inhibitor
3. 3gmd: Structure-based Design of 7-azaindole-pyrrolidines as Inhibitors of 11beta-hydroxysteroid-dehydrogenase Type I
4. 3g49: N-(pyridin-2-yl) Arylsulfonamide Inhibitors of 11b- Hydroxysteroid Dehydrogenase Type 1: Discovery of Pf-915275
5. 3frj: Crystal Structure of 11b-hydroxysteroid Dehydrogenase-1 (11b-hsd1) in Complex with Piperidyl Benzamide Inhibitor
6. 3fco: Crystal Structure of 11beta-hydroxysteroid Dehydrogenase 1 (11b-hsd1) in Complex with Benzamide Inhibitor
7. 3ey4: Further Studies with The 2-amino-1,3-thiazol-4(5h)-one Class of 11-hydroxysteroid Dehydrogenase Type 1 (11-hsd1) Inhibitors: Reducing Pregnane X Receptor (pxr) Activity and Exploring Activity in a Monkey Pharmacodynamic Model
8. 3dwf: Crystal Structure of The Guinea Pig 11beta-hydroxysteroid Dehydrogenase Type 1 Mutant F278E
9. 3d5q: Crystal Structure of 11b-hsd1 in Complex with Triazole Inhibitor
10. 3d4n: Crystal Structure of Human 11-beta-hydroxysteroid Dehydrogenase (hsd1) in Complex with Sulfonamide Inhibitor
11. 3d3e: Crystal Structure of Human 11-beta-hydroxysteroid Dehydrogenase (hsd1) in Complex with Benzamide Inhibitor
12. 3czr: Crystal Structure of Human 11-beta-hydroxysteroid Dehydrogenase (hsd1) in Complex with Arylsulfonylpiperazine Inhibitor
13. 3ch6: Crystal Structure of 11beta-hsd1 Double Mutant (L262R, F278E) Complexed with (3,3-dimethylpiperidin-1-yl)(6-(3- Fluoro-4-methylphenyl)pyridin-2-yl)methanone
14. 3bzu: Crystal Structure of Human 11-beta-hydroxysteroid Dehydrogenase(hsd1) in Complex with Nadp and Thiazolone Inhibitor
15. 3byz: 2-amino-1,3-thiazol-4(5h)-ones as Potent and Selective 11- Hydroxysteroid Dehydrogenase Type 1 Inhibitors
16. 1xse: Crystal Structure of Guinea Pig 11beta-hydroxysteroid Dehydrogenase Type 1
17. 1xu7: Crystal Structure of The Interface Open Conformation of Tetrameric 11b-hsd1
18. 1xu9: Crystal Structure of The Interface Closed Conformation of 11b-hydroxysteroid Dehydrogenase Isozyme 1
19. 1y5m: The Crystal Structure of Murine 11b-hydroxysteroid Dehydrogenase: an Important Therapeutic Target for Diabetes
20. 1y5r: The Crystal Structure of Murine 11b-hydroxysteroid Dehydrogenase Complexed with Corticosterone
21. 2bel: Structure of Human 11-beta-hydroxysteroid Dehydrogenase in Complex with Nadp and Carbenoxolone
22. 2rbe: The Discovery of 2-anilinothiazolones as 11beta-hsd1 Inhibitors
23. 2ilt: Human 11-beta-hydroxysteroid Dehydrogenase (hsd1) with Nadp and Adamantane Sulfone Inhibitor
24. 2irw: Human 11-beta-hydroxysteroid Dehydrogenase (hsd1) with Nadp and Adamantane Ether Inhibitor
25. 3lz6: Guinea Pig 11beta Hydroxysteroid Dehydrogenase with Pf-877423
26. 3oq1: Crystal Structure of 11beta-hydroxysteroid Dehydrogenase-1 (11b-hsd1) in Complex with Diarylsulfone Inhibitor
27. 3pdj: Crystal Structure of Human 11-beta-hydroxysteroid Dehydrogenase 1 (11b-hsd1) in Complex with 4,4-disubstituted Cyclohexylbenzamide Inhibitor
28. 3tfq: Crystal Structure of 11b-hsd1 Double Mutant (L262R, F278E) Complexed with 8-{[(2-cyanopyridin-3-yl)methyl]sulfanyl}-6-hydroxy-3,4-dihydro- 1h-pyrano[3,4-c]pyridine-5-carbonitrile
29. 3qqp: Crystal Structure of 11beta-hydroxysteroid Dehydrogenase 1 (11b-hsd1) in Complex with Urea Inhibitor
30. 6nj7: 11-beta Dehydrogenase Isozyme 1 in Complex with Colletoic Acid
31. 4hfr: Human 11beta-hydroxysteroid Dehydrogenase Type 1 in Complex with an Orally Bioavailable Acidic Inhibitor Azd4017.
32. 4bb5: Free-wilson and Structural Approaches to Co-optimising Human and Rodent Isoform Potency for 11b-hydroxysteroid Dehydrogenase Type 1 11b-hsd1 Inhibitors
33. 4bb6: Free-wilson and Structural Approaches to Co-optimising Human and Rodent Isoform Potency for 11b-hydroxysteroid Dehydrogenase Type 1 11b-hsd1 Inhibitors
34. 4hx5: Crystal Structure of 11 Beta-hsd1 in Complex with Sar184841
35. 4c7j: 11b-hydroxysteroid Dehydrogenase Type I in Complex with Inhibitor
36. 4c7k: 11b-hydroxysteroid Dehydrogenase Type I in Complex with Inhibitor
37. 4iju: Crystal Structure of 11b-hsd1 Double Mutant (L262R, F278E) in Complex with (1s,4s)-4-[8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridin-3- Yl]bicyclo[2.2.1]heptan-1-ol
38. 4ijv: Crystal Structure of 11b-hsd1 Double Mutant (L262R, F278E) in Complex with 3-[1-(4-chlorophenyl)cyclopropyl]-8-(2-fluorophenoxy)[1,2, 4]triazolo[4,3-a]pyridine
39. 4ijw: Crystal Structure of 11b-hsd1 Double Mutant (L262R, F278E) in Complex with 3-[1-(4-chlorophenyl)cyclopropyl]-8-cyclopropyl[1,2, 4]triazolo[4,3-a]pyridine
40. 4k1l: 4,4-dioxo-5,6-dihydro-[1,4,3]oxathiazines, a Novel Class of 11 Beta- Hsd1 Inhibitors for The Treatment of Diabetes
41. 4k26: 4,4-dioxo-5,6-dihydro-[1,4,3]oxathiazines, a Novel Class of 11 -hsd1 Inhibitors for The Treatment of Diabetes
42. 4nmh: 11-beta-hsd1 in Complex with a 3,3-di-methyl-azetidin-2-one
43. 4p38: Human 11beta-hydroxysteroid Dehydrogenase Type 1 in Complex with Azd8329
44. 5qij: Crystal Structure of Murine 11b- Hydroxysteroiddehydrogenase Complexed with 2-(3-(1-(4- Chlorophenyl)cyclopropyl)-[1,2,4]triazolo[4,3- A]pyridin-8- Yl)propan-2-ol
45. 5qii: Crystal Structure of 11beta-hsd1 Double Mutant (L262R, F278E) Complexed with 2-(3-(1-(4-chlorophenyl)cyclopropyl) -[1,2, 4]triazolo[4,3-a]pyridin-8-yl)propan-2-ol
46. 5pgz: Crystal Structure of Murine 11beta- Hydroxysteroiddehydrogenase Complexed with 2-[(5r,7s)-6-hydroxy-2-phenyladamantan-2-yl]-1-(3- Hydroxyazetidin-1-yl)ethan-1-one (bms-816336)
47. 5pgy: Crystal Structure of 11beta-hsd1 Double Mutant (L262R, F278E) Complexed with 2-[(5r,7s)-6-hydroxy-2-phenyladamantan-2-yl]-1-(3- Hydroxyazetidin-1-yl)ethan-1-one (bms-816336)
48. 5pgx: Crystal Structure of 11beta-hsd1 Double Mutant (L262R, F278E) Complexed with 2-(2-benzyl-6-hydroxyadamantan-2-yl)-1-(3- Hydroxyazetidin-1-yl)ethan-1-one
49. 5pgw: Crystal Structure of 11beta-hsd1 Double Mutant (L262R, F278E) Complexed with 2-[(1r,3s,5r,7s)-2-[4-(4-fluorophenyl)phenyl]-6- Hydroxyadamantan-2-yl]-1-(3- Hydroxyazetidin-1-yl)ethan-1-one
50. 5pgv: Crystal Structure of 11beta-hsd1 Double Mutant (L262R, F278E) Complexed with 1-(3-hydroxyazetidin-1-yl)-2-[(2s,5r)-2-(4- Fluorophenyl)-5-methoxyadamantan-2-yl]ethan-1-one
51. 5pgu: Crystal Structure of 11beta-hsd1 Double Mutant (L262R, F278E) Complexed with 2-[2-(4-fluorophenyl)-2-adamantyl]-1-(3- Methoxyazetidin-1-yl)ethanone
52. 4yyz: 11b-hydroxysteroid Dehydrogenase Type I in Complex with Inhibitor