Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy   |   
enzyme (lysozyme)

 
Enzymes
  Enzyme classes:
  EC 1: Oxidoreductases
    EC 1.1
      EC 1.1.1
        EC 1.1.1.1
        EC 1.1.1.2
        EC 1.1.1.3
        EC 1.1.1.4
        EC 1.1.1.5
        EC 1.1.1.6
        EC 1.1.1.7
        EC 1.1.1.8
        EC 1.1.1.9
        EC 1.1.1.10
        EC 1.1.1.11
        EC 1.1.1.12
        EC 1.1.1.13
        EC 1.1.1.14
        EC 1.1.1.15
        EC 1.1.1.16
        EC 1.1.1.17
        EC 1.1.1.18
        EC 1.1.1.19
        EC 1.1.1.20
        EC 1.1.1.21
        EC 1.1.1.22
        EC 1.1.1.23
        EC 1.1.1.24
        EC 1.1.1.25
        EC 1.1.1.26
        EC 1.1.1.27
        EC 1.1.1.28
        EC 1.1.1.29
        EC 1.1.1.30
        EC 1.1.1.31
        EC 1.1.1.32
        EC 1.1.1.33
        EC 1.1.1.34
        EC 1.1.1.35
        EC 1.1.1.36
        EC 1.1.1.37
        EC 1.1.1.38
        EC 1.1.1.39
        EC 1.1.1.40
        EC 1.1.1.41
        EC 1.1.1.42
        EC 1.1.1.43
        EC 1.1.1.44
        EC 1.1.1.45
        EC 1.1.1.46
        EC 1.1.1.47
        EC 1.1.1.48
        EC 1.1.1.49
        EC 1.1.1.50
        EC 1.1.1.51
        EC 1.1.1.52
        EC 1.1.1.53
        EC 1.1.1.54
        EC 1.1.1.55
        EC 1.1.1.56
        EC 1.1.1.57
        EC 1.1.1.58
        EC 1.1.1.59
        EC 1.1.1.60
        EC 1.1.1.61
        EC 1.1.1.62
        EC 1.1.1.63
        EC 1.1.1.64
        EC 1.1.1.65
        EC 1.1.1.66
        EC 1.1.1.67
        EC 1.1.1.68
        EC 1.1.1.69
        EC 1.1.1.70
        EC 1.1.1.71
        EC 1.1.1.72
        EC 1.1.1.73
        EC 1.1.1.74
        EC 1.1.1.75
        EC 1.1.1.76
        EC 1.1.1.77
        EC 1.1.1.78
        EC 1.1.1.79
        EC 1.1.1.80
        EC 1.1.1.81
        EC 1.1.1.82
        EC 1.1.1.83
        EC 1.1.1.84
        EC 1.1.1.85
        EC 1.1.1.86
        EC 1.1.1.87
        EC 1.1.1.88
        EC 1.1.1.89
        EC 1.1.1.90
        EC 1.1.1.91
        EC 1.1.1.92
        EC 1.1.1.93
        EC 1.1.1.94
        EC 1.1.1.95
        EC 1.1.1.96
        EC 1.1.1.97
        EC 1.1.1.98
        EC 1.1.1.99
        EC 1.1.1.100
        EC 1.1.1.101
        EC 1.1.1.102
        EC 1.1.1.103
        EC 1.1.1.104
        EC 1.1.1.105
        EC 1.1.1.106
        EC 1.1.1.107
        EC 1.1.1.108
        EC 1.1.1.109
        EC 1.1.1.110
        EC 1.1.1.111
        EC 1.1.1.112
        EC 1.1.1.113
        EC 1.1.1.114
        EC 1.1.1.115
        EC 1.1.1.116
        EC 1.1.1.117
        EC 1.1.1.118
        EC 1.1.1.119
        EC 1.1.1.120
        EC 1.1.1.121
        EC 1.1.1.122
        EC 1.1.1.123
        EC 1.1.1.124
        EC 1.1.1.125
        EC 1.1.1.126
        EC 1.1.1.127
        EC 1.1.1.128
        EC 1.1.1.129
        EC 1.1.1.130
        EC 1.1.1.131
        EC 1.1.1.132
        EC 1.1.1.133
        EC 1.1.1.134
        EC 1.1.1.135
        EC 1.1.1.136
        EC 1.1.1.137
        EC 1.1.1.138
        EC 1.1.1.139
        EC 1.1.1.140
        EC 1.1.1.141
        EC 1.1.1.142
        EC 1.1.1.143
        EC 1.1.1.144
        EC 1.1.1.145
        EC 1.1.1.146
        EC 1.1.1.147
        EC 1.1.1.148
        EC 1.1.1.149
        EC 1.1.1.150
        EC 1.1.1.151
        EC 1.1.1.152
        EC 1.1.1.153
        EC 1.1.1.154
        EC 1.1.1.155
        EC 1.1.1.156
        EC 1.1.1.157
        EC 1.1.1.158
        EC 1.1.1.159
        EC 1.1.1.160
        EC 1.1.1.161
        EC 1.1.1.162
        EC 1.1.1.163
        EC 1.1.1.164
        EC 1.1.1.165
        EC 1.1.1.166
        EC 1.1.1.167
        EC 1.1.1.168
        EC 1.1.1.169
        EC 1.1.1.170
        EC 1.1.1.171
        EC 1.1.1.172
        EC 1.1.1.173
        EC 1.1.1.174
        EC 1.1.1.175
        EC 1.1.1.176
        EC 1.1.1.177
        EC 1.1.1.178
        EC 1.1.1.179
        EC 1.1.1.180
        EC 1.1.1.181
        EC 1.1.1.182
        EC 1.1.1.183
        EC 1.1.1.184
        EC 1.1.1.185
        EC 1.1.1.186
        EC 1.1.1.187
        EC 1.1.1.188
        EC 1.1.1.189
        EC 1.1.1.190
        EC 1.1.1.191
        EC 1.1.1.192
        EC 1.1.1.193
        EC 1.1.1.194
        EC 1.1.1.195
        EC 1.1.1.196
        EC 1.1.1.197
        EC 1.1.1.198
        EC 1.1.1.199
        EC 1.1.1.200
        EC 1.1.1.201
        EC 1.1.1.202
        EC 1.1.1.203
        EC 1.1.1.204
        EC 1.1.1.205
        EC 1.1.1.206
        EC 1.1.1.207
        EC 1.1.1.208
        EC 1.1.1.209
        EC 1.1.1.210
        EC 1.1.1.211
        EC 1.1.1.212
        EC 1.1.1.213
        EC 1.1.1.214
        EC 1.1.1.215
        EC 1.1.1.216
        EC 1.1.1.217
        EC 1.1.1.218
        EC 1.1.1.219
        EC 1.1.1.220
        EC 1.1.1.221
        EC 1.1.1.222
        EC 1.1.1.223
        EC 1.1.1.224
        EC 1.1.1.225
        EC 1.1.1.226
        EC 1.1.1.227
        EC 1.1.1.228
        EC 1.1.1.229
        EC 1.1.1.230
        EC 1.1.1.231
        EC 1.1.1.232
        EC 1.1.1.233
        EC 1.1.1.234
        EC 1.1.1.235
        EC 1.1.1.236
        EC 1.1.1.237
        EC 1.1.1.238
        EC 1.1.1.239
        EC 1.1.1.240
        EC 1.1.1.241
        EC 1.1.1.242
        EC 1.1.1.243
        EC 1.1.1.244
        EC 1.1.1.245
        EC 1.1.1.246
        EC 1.1.1.247
        EC 1.1.1.248
        EC 1.1.1.249
        EC 1.1.1.250
        EC 1.1.1.251
        EC 1.1.1.252
        EC 1.1.1.253
        EC 1.1.1.254
        EC 1.1.1.255
        EC 1.1.1.256
        EC 1.1.1.257
        EC 1.1.1.258
        EC 1.1.1.259
        EC 1.1.1.260
        EC 1.1.1.261
        EC 1.1.1.262
        EC 1.1.1.263
        EC 1.1.1.264
        EC 1.1.1.265
        EC 1.1.1.266
        EC 1.1.1.267
        EC 1.1.1.273
        EC 1.1.1.274
        EC 1.1.1.275
        EC 1.1.1.276
        EC 1.1.1.277
        EC 1.1.1.278
        EC 1.1.1.281
        EC 1.1.1.282
        EC 1.1.1.283
        EC 1.1.1.284
        EC 1.1.1.285
        EC 1.1.1.286
        EC 1.1.1.287
        EC 1.1.1.288
        EC 1.1.1.289
        EC 1.1.1.290
        EC 1.1.1.291
        EC 1.1.1.292
        EC 1.1.1.293
        EC 1.1.1.294
        EC 1.1.1.295
        EC 1.1.1.296
        EC 1.1.1.297
      EC 1.1.2
      EC 1.1.3
      EC 1.1.4
      EC 1.1.5
      EC 1.1.99
    EC 1.2
    EC 1.3
    EC 1.4
    EC 1.5
    EC 1.6
    EC 1.7
    EC 1.8
    EC 1.9
    EC 1.10
    EC 1.11
    EC 1.12
    EC 1.13
    EC 1.14
    EC 1.15
    EC 1.16
    EC 1.17
    EC 1.18
    EC 1.19
    EC 1.20
    EC 1.21
    EC 1.97
    EC 1.98
    EC 1.99
  EC 2: Transferases
  EC 3: Hydrolases
  EC 4: Lyases
  EC 5: Isomerases
  EC 6: Ligases
  General information:
  Catalytic mechanism
  Enzyme kinetics
  Inhibitors
  Enzymes in industry

EC 1.1.1.146 - 11β- hydroxysteroid:NADP + 11- oxidoreductase (11\xCE\xB2- hydroxysteroid dehydrogenase)



3D structures of EC 1.1.1.146 - 11\xCE\xB2-hydroxysteroid dehydrogenase in Protein Data Bank

updated: 6 January 2022, 2:15

In total: 52 PDB structures of EC 1.1.1.146 - 11\xCE\xB2-hydroxysteroid dehydrogenase:
  1. 3hfg: Crystal Structure of Human 11-beta-hydroxysteroid- Dehydrogenase Bound to an Sulfonyl-piperazine Inhibitor
  2. 3h6k: Crystal Structure of Human 11-beta-hydroxysteroid- Dehydrogenase Bound to an Ortho-chlro-sulfonyl-piperazine Inhibitor
  3. 3gmd: Structure-based Design of 7-azaindole-pyrrolidines as Inhibitors of 11beta-hydroxysteroid-dehydrogenase Type I
  4. 3g49: N-(pyridin-2-yl) Arylsulfonamide Inhibitors of 11b- Hydroxysteroid Dehydrogenase Type 1: Discovery of Pf-915275
  5. 3frj: Crystal Structure of 11b-hydroxysteroid Dehydrogenase-1 (11b-hsd1) in Complex with Piperidyl Benzamide Inhibitor
  6. 3fco: Crystal Structure of 11beta-hydroxysteroid Dehydrogenase 1 (11b-hsd1) in Complex with Benzamide Inhibitor
  7. 3ey4: Further Studies with The 2-amino-1,3-thiazol-4(5h)-one Class of 11-hydroxysteroid Dehydrogenase Type 1 (11-hsd1) Inhibitors: Reducing Pregnane X Receptor (pxr) Activity and Exploring Activity in a Monkey Pharmacodynamic Model
  8. 3dwf: Crystal Structure of The Guinea Pig 11beta-hydroxysteroid Dehydrogenase Type 1 Mutant F278E
  9. 3d5q: Crystal Structure of 11b-hsd1 in Complex with Triazole Inhibitor
  10. 3d4n: Crystal Structure of Human 11-beta-hydroxysteroid Dehydrogenase (hsd1) in Complex with Sulfonamide Inhibitor
  11. 3d3e: Crystal Structure of Human 11-beta-hydroxysteroid Dehydrogenase (hsd1) in Complex with Benzamide Inhibitor
  12. 3czr: Crystal Structure of Human 11-beta-hydroxysteroid Dehydrogenase (hsd1) in Complex with Arylsulfonylpiperazine Inhibitor
  13. 3ch6: Crystal Structure of 11beta-hsd1 Double Mutant (L262R, F278E) Complexed with (3,3-dimethylpiperidin-1-yl)(6-(3- Fluoro-4-methylphenyl)pyridin-2-yl)methanone
  14. 3bzu: Crystal Structure of Human 11-beta-hydroxysteroid Dehydrogenase(hsd1) in Complex with Nadp and Thiazolone Inhibitor
  15. 3byz: 2-amino-1,3-thiazol-4(5h)-ones as Potent and Selective 11- Hydroxysteroid Dehydrogenase Type 1 Inhibitors
  16. 1xse: Crystal Structure of Guinea Pig 11beta-hydroxysteroid Dehydrogenase Type 1
  17. 1xu7: Crystal Structure of The Interface Open Conformation of Tetrameric 11b-hsd1
  18. 1xu9: Crystal Structure of The Interface Closed Conformation of 11b-hydroxysteroid Dehydrogenase Isozyme 1
  19. 1y5m: The Crystal Structure of Murine 11b-hydroxysteroid Dehydrogenase: an Important Therapeutic Target for Diabetes
  20. 1y5r: The Crystal Structure of Murine 11b-hydroxysteroid Dehydrogenase Complexed with Corticosterone
  21. 2bel: Structure of Human 11-beta-hydroxysteroid Dehydrogenase in Complex with Nadp and Carbenoxolone
  22. 2rbe: The Discovery of 2-anilinothiazolones as 11beta-hsd1 Inhibitors
  23. 2ilt: Human 11-beta-hydroxysteroid Dehydrogenase (hsd1) with Nadp and Adamantane Sulfone Inhibitor
  24. 2irw: Human 11-beta-hydroxysteroid Dehydrogenase (hsd1) with Nadp and Adamantane Ether Inhibitor
  25. 3lz6: Guinea Pig 11beta Hydroxysteroid Dehydrogenase with Pf-877423
  26. 3oq1: Crystal Structure of 11beta-hydroxysteroid Dehydrogenase-1 (11b-hsd1) in Complex with Diarylsulfone Inhibitor
  27. 3pdj: Crystal Structure of Human 11-beta-hydroxysteroid Dehydrogenase 1 (11b-hsd1) in Complex with 4,4-disubstituted Cyclohexylbenzamide Inhibitor
  28. 3tfq: Crystal Structure of 11b-hsd1 Double Mutant (L262R, F278E) Complexed with 8-{[(2-cyanopyridin-3-yl)methyl]sulfanyl}-6-hydroxy-3,4-dihydro- 1h-pyrano[3,4-c]pyridine-5-carbonitrile
  29. 3qqp: Crystal Structure of 11beta-hydroxysteroid Dehydrogenase 1 (11b-hsd1) in Complex with Urea Inhibitor
  30. 6nj7: 11-beta Dehydrogenase Isozyme 1 in Complex with Colletoic Acid
  31. 4hfr: Human 11beta-hydroxysteroid Dehydrogenase Type 1 in Complex with an Orally Bioavailable Acidic Inhibitor Azd4017.
  32. 4bb5: Free-wilson and Structural Approaches to Co-optimising Human and Rodent Isoform Potency for 11b-hydroxysteroid Dehydrogenase Type 1 11b-hsd1 Inhibitors
  33. 4bb6: Free-wilson and Structural Approaches to Co-optimising Human and Rodent Isoform Potency for 11b-hydroxysteroid Dehydrogenase Type 1 11b-hsd1 Inhibitors
  34. 4hx5: Crystal Structure of 11 Beta-hsd1 in Complex with Sar184841
  35. 4c7j: 11b-hydroxysteroid Dehydrogenase Type I in Complex with Inhibitor
  36. 4c7k: 11b-hydroxysteroid Dehydrogenase Type I in Complex with Inhibitor
  37. 4iju: Crystal Structure of 11b-hsd1 Double Mutant (L262R, F278E) in Complex with (1s,4s)-4-[8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridin-3- Yl]bicyclo[2.2.1]heptan-1-ol
  38. 4ijv: Crystal Structure of 11b-hsd1 Double Mutant (L262R, F278E) in Complex with 3-[1-(4-chlorophenyl)cyclopropyl]-8-(2-fluorophenoxy)[1,2, 4]triazolo[4,3-a]pyridine
  39. 4ijw: Crystal Structure of 11b-hsd1 Double Mutant (L262R, F278E) in Complex with 3-[1-(4-chlorophenyl)cyclopropyl]-8-cyclopropyl[1,2, 4]triazolo[4,3-a]pyridine
  40. 4k1l: 4,4-dioxo-5,6-dihydro-[1,4,3]oxathiazines, a Novel Class of 11 Beta- Hsd1 Inhibitors for The Treatment of Diabetes
  41. 4k26: 4,4-dioxo-5,6-dihydro-[1,4,3]oxathiazines, a Novel Class of 11 -hsd1 Inhibitors for The Treatment of Diabetes
  42. 4nmh: 11-beta-hsd1 in Complex with a 3,3-di-methyl-azetidin-2-one
  43. 4p38: Human 11beta-hydroxysteroid Dehydrogenase Type 1 in Complex with Azd8329
  44. 5qij: Crystal Structure of Murine 11b- Hydroxysteroiddehydrogenase Complexed with 2-(3-(1-(4- Chlorophenyl)cyclopropyl)-[1,2,4]triazolo[4,3- A]pyridin-8- Yl)propan-2-ol
  45. 5qii: Crystal Structure of 11beta-hsd1 Double Mutant (L262R, F278E) Complexed with 2-(3-(1-(4-chlorophenyl)cyclopropyl) -[1,2, 4]triazolo[4,3-a]pyridin-8-yl)propan-2-ol
  46. 5pgz: Crystal Structure of Murine 11beta- Hydroxysteroiddehydrogenase Complexed with 2-[(5r,7s)-6-hydroxy-2-phenyladamantan-2-yl]-1-(3- Hydroxyazetidin-1-yl)ethan-1-one (bms-816336)
  47. 5pgy: Crystal Structure of 11beta-hsd1 Double Mutant (L262R, F278E) Complexed with 2-[(5r,7s)-6-hydroxy-2-phenyladamantan-2-yl]-1-(3- Hydroxyazetidin-1-yl)ethan-1-one (bms-816336)
  48. 5pgx: Crystal Structure of 11beta-hsd1 Double Mutant (L262R, F278E) Complexed with 2-(2-benzyl-6-hydroxyadamantan-2-yl)-1-(3- Hydroxyazetidin-1-yl)ethan-1-one
  49. 5pgw: Crystal Structure of 11beta-hsd1 Double Mutant (L262R, F278E) Complexed with 2-[(1r,3s,5r,7s)-2-[4-(4-fluorophenyl)phenyl]-6- Hydroxyadamantan-2-yl]-1-(3- Hydroxyazetidin-1-yl)ethan-1-one
  50. 5pgv: Crystal Structure of 11beta-hsd1 Double Mutant (L262R, F278E) Complexed with 1-(3-hydroxyazetidin-1-yl)-2-[(2s,5r)-2-(4- Fluorophenyl)-5-methoxyadamantan-2-yl]ethan-1-one
  51. 5pgu: Crystal Structure of 11beta-hsd1 Double Mutant (L262R, F278E) Complexed with 2-[2-(4-fluorophenyl)-2-adamantyl]-1-(3- Methoxyazetidin-1-yl)ethanone
  52. 4yyz: 11b-hydroxysteroid Dehydrogenase Type I in Complex with Inhibitor
© Copyright 2008-2009 by enzymes.me.uk