EC 1.1.1.27 - ( S ) - lactate:NAD ⁺ oxidoreductase ( L - lactate dehydrogenase)

3D structures of EC 1.1.1.27 - L-lactate dehydrogenase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1a5z: Lactate Dehydrogenase from Thermotoga Maritima (tmldh)
2. 1ceq: Chloroquine Binds in The Cofactor Binding Site of Plasmodium Falciparum Lactate Dehydrogenase.
3. 1cet: Chloroquine Binds in The Cofactor Binding Site of Plasmodium Falciparum Lactate Dehydrogenase.
4. 1ez4: Crystal Structure of Non-allosteric L-lactate Dehydrogenase from Lactobacillus Pentosus at 2.3 Angstrom Resolution
5. 1hye: Crystal Structure of The Mj0490 Gene Product, The Family of Lactate/malate Dehydrogenase, Dimeric Structure
6. 1hyg: Crystal Structure of Mj0490 Gene Product, The Family of Lactate/malate Dehydrogenase
7. 1hyh: Crystal Structure of L-2-hydroxyisocaproate Dehydrogenase from Lactobacillus Confusus at 2.2 Angstroms Resolution-an Example of Strong Asymmetry between Subunits
8. 1i0z: Human Heart L-lactate Dehydrogenase H Chain, Ternary Complex with Nadh and Oxamate
9. 1i10: Human Muscle L-lactate Dehydrogenase M Chain, Ternary Complex with Nadh and Oxamate
10. 9ldt: Design and Synthesis of New Enzymes Based on The Lactate Dehydrogenase Framework
11. 9ldb: Design and Synthesis of New Enzymes Based on The Lactate Dehydrogenase Framework
12. 8ldh: Refined Crystal Structure of Dogfish M4 Apo-lactate Dehydrogenase
13. 6ldh: Refined Crystal Structure of Dogfish M4 Apo-lactate Dehydrogenase
14. 5ldh: Structure of The Active Ternary Complex of Pig Heart Lactate Dehydrogenase with S-lac-nad at 2.7 Angstroms Resolution
15. 3om9: T. Gondii Bradyzoite-specific Ldh (ldh1) in Complex with Nad and Oxq
16. 1ldb: Structure Determination and Refinement of Bacillus Stearothermophilus Lactate Dehydrogenase
17. 1ldg: Plasmodium Falciparum L-lactate Dehydrogenase Complexed with Nadh and Oxamate
18. 1ldm: Refined Crystal Structure of Dogfish M4 Apo-lactate Dehydrogenase
19. 1ldn: Structure of a Ternary Complex of an Allosteric Lactate Dehydrogenase from Bacillus Stearothermophilus at 2.5 Angstroms Resolution
20. 1llc: Structure Determination of The Allosteric L-lactate Dehydrogenase from Lactobacillus Casei at 3.0 Angstroms Resolution
21. 1lld: Molecular Basis of Allosteric Activation of Bacterial L- Lactate Dehydrogenase
22. 1lth: T and R States in The Crystals of Bacterial L-lactate Dehydrogenase Reveal The Mechanism for Allosteric Control
23. 3ldh: A Comparison of The Structures of Apo Dogfish M4 Lactate Dehydrogenase and Its Ternary Complexes
24. 1oc4: Lactate Dehydrogenase from Plasmodium Berghei
25. 1pze: T.gondii Ldh1 Apo Form
26. 1pzf: T.gondii Ldh1 Ternary Complex with Apad+ and Oxalate
27. 1pzg: T.gondii Ldh1 Complexed with Apad and Sulfate at 1.6 Angstroms
28. 1pzh: T.gondii Ldh1 Ternary Complex with Nad and Oxalate
29. 3h3j: Crystal Structure of Lactate Dehydrogenase Mutant (A85R) from Staphylococcus Aureus Complexed with Nad and Pyruvate
30. 3h3f: Rabbit Muscle L-lactate Dehydrogenase in Complex with Nadh and Oxamate
31. 1sov: Toxoplasma Gondii Bradyzoite-specific Ldh (ldh2) Apo Form
32. 1sow: T. Gondii Bradyzoite-specific Ldh (ldh2) in Complex with Nad and Oxalate
33. 1t24: Plasmodium Falciparum Lactate Dehydrogenase Complexed with Nad+ and 4-hydroxy-1,2,5-oxadiazole-3-carboxylic Acid
34. 1t25: Plasmodium Falciparum Lactate Dehydrogenase Complexed with Nadh and 3-hydroxyisoxazole-4-carboxylic Acid
35. 1t26: Plasmodium Falciparum Lactate Dehydrogenase Complexed with Nadh and 4-hydroxy-1,2,5-thiadiazole-3-carboxylic Acid
36. 1t2c: Plasmodium Falciparum Lactate Dehydrogenase Complexed with Nadh
37. 1t2d: Plasmodium Falciparum Lactate Dehydrogenase Complexed with Nad+ and Oxalate
38. 1t2e: Plasmodium Falciparum Lactate Dehydrogenase S245A, A327P Mutant Complexed with Nadh and Oxamate
39. 1t2f: Human B Lactate Dehydrogenase Complexed with Nad+ and 4- Hydroxy-1,2,5-oxadiazole-3-carboxylic Acid
40. 1u4o: Plasmodium Falciparum Lactate Dehydrogenase Complexed with 2,6-naphthalenedicarboxylic Acid
41. 1u4s: Plasmodium Falciparum Lactate Dehydrogenase Complexed with 2,6-naphthalenedisulphonic Acid
42. 1u5a: Plasmodium Falciparum Lactate Dehydrogenase Complexed with 3,5-dihydroxy-2-naphthoic Acid
43. 1u5c: Plasmodium Falciparum Lactate Dehydrogenase Complexed with 3,7-dihydroxynaphthalene-2-carboxylic Acid and Nad+
44. 3d4p: Crystal Structure of Lactate Dehydrogenase from Staphylococcus Aureus Complexed with Nad and Pyruvate
45. 3d0o: Crystal Structure of Lactate Dehydrogenase from Staphylococcus Aureus
46. 3czm: T. Gondii Bradyzoite-specific Ldh (ldh2) in Complex with Nad and Oxq
47. 1v6a: Crystal Structure of L-lactate Dehydrogenase from Cyprinus Carpio
48. 1vbi: Crystal Structure of Type 2 Malate/lactate Dehydrogenase from Thermus Thermophilus Hb8
49. 2zqz: R-state Structure of Allosteric L-lactate Dehydrogenase from Lactobacillus Casei
50. 2zqy: T-state Structure of Allosteric L-lactate Dehydrogenase from Lactobacillus Casei
51. 1x0a: Crystal Structure of Type II Malate/lactate Dehydrogenase from Thermus Thermophilus Hb8
52. 1xiv: Plasmodium Falciparum Lactate Dehydrogenase Complexed with 2-({4-chloro-[hydroxy(methoxy)methyl]cyclohexyl}amino) Ethane-1,1,2-triol
53. 2xxj: Penta Mutant of Lactate Dehydrogenase from Thermus Thermophilus, Ternary Complex
54. 2xxb: Penta-mutant of Thermus Thermophilus Lactate Dehydrogenase, Complex with Amp
55. 2x8l: Plasmodium Falciparum Lactate Dehydrogenase Apo Structure
56. 1y6j: L-lactate Dehydrogenase from Clostridium Thermocellum Cth- 1135
57. 2a92: Crystal Structure of Lactate Dehydrogenase from Plasmodium Vivax: Complex with Nadh
58. 2a94: Structure of Plasmodium Falciparum Lactate Dehydrogenase Complexed to Apadh.
59. 2aa3: Crystal Structure of Plasmodium Vivax Lactate Dehydrogenase Complex with Apadh
60. 2v7p: Crystal Structure of Lactate Dehydrogenase from Thermus Thermophilus Hb8 (holo Form)
61. 2v6m: Crystal Structure of Lactate Dehydrogenase from Thermus Thermophilus Hb8 (apo Form)
62. 2v6b: Crystal Structure of Lactate Dehydrogenase from Deinococcus Radiodurans (apo Form)
63. 2v65: Apo Ldh from The Psychrophile C. Gunnari
64. 6bb3: Lactate Dehydrogenase in Complex with Inhibitor 3-((2-chlorophenyl) Thio)-6-(6-((4-fluorophenyl)amino)pyridin-2-yl)-4-hydroxy-6- (thiophen-3-yl)-5,6-dihydro-2h-pyran-2-one
65. 6bb2: Lactate Dehydrogenase in Complex with Inhibitor (s)-5-((2- Chlorophenyl)thio)-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)- 2,3-dihydro-[2,2'-bipyridin]-6(1h)-one
66. 6bb1: Lactate Dehydrogenase in Complex with Inhibitor (r)-5-((2- Chlorophenyl)thio)-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)- 2,3-dihydro-[2,2'-bipyridin]-6(1h)-one
67. 6bb0: Lactate Dehydrogenase in Complex with Inhibitor (r)-3-((2- Chlorophenyl)thio)-6-(3-((4-fluorophenyl)amino)phenyl)-4-hydroxy-6- (thiophen-3-yl)-5,6-dihydro-2h-pyran-2-one
68. 6baz: Lactate Dehydrogenase in Complex with Inhibitor (s)-5-((2- Chlorophenyl)thio)-6'-((4-fluorophenyl)amino)-4-hydroxy-2-(thiophen- 3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1h)-one
69. 6bax: Lactate Dehydrogenase in Complex with Inhibitor 6-(3-aminophenyl)-3- ((2-chlorophenyl)thio)-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2h- Pyran-2-one
70. 6bag: Lactate Dehydrogenase in Complex with Inhibitor (r)-5-((2- Chlorophenyl)thio)-6'-((4-fluorophenyl)amino)-4-hydroxy-2-(thiophen- 3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1h)-one
71. 6bad: Lactate Dehydrogenase in Complex with Inhibitor (r)-3-((2- Chlorophenyl)thio)-6-(3-((4-fluorophenyl)amino)phenyl)-4-hydroxy-6- (thiophen-3-yl)-5,6-dihydro-2h-pyran-2-one
72. 2e37: Structure of Tt0471 Protein from Thermus Thermophilus
73. 2ldx: Characterization of The Antigenic Sites on The Refined 3- Angstroms Resolution Structure of Mouse Testicular Lactate Dehydrogenase C4
74. 2ldb: Structure Determination and Refinement of Bacillus Stearothermophilus Lactate Dehydrogenase
75. 5zjf: Ldha-ma
76. 5zje: Ldha-mla
77. 5zjd: Lactate Dehydrogenase with Nadh and Mla
78. 2fn7: Crystal Structure of The Lactate Dehydrogenase from Cryptosporidium Parvum Complexed with Substrate (lactic Acid) and Cofactor (b-nicotinamide Adenine Dinucleotide)
79. 5yta: Pig Heart Lactate Dehydrogenase in Complex with Nadh and Oxamate
80. 6txr: Structural Insights into Cubane-modified Aptamer Recognition of a Malaria Biomarker
81. 6q13: Crystal Structure of Ldha in Complex with Compound Ncgc00420737-09 at 2.00 a Resolution
82. 6q0d: Crystal Structure of Ldha in Complex with Compound Ncgc00384414-01 at 2.05 a Resolution
83. 6p6u: Crystal Structure of Monoclinic Rabbit Muscle Lactate Dehydrogenase with Four Tetramers as The Asymmetric Unit
84. 6sbv: X-ray Structure of Human Ldh-a with an Allosteric Inhibitor (compound 7)
85. 6sbu: X-ray Structure of Human Ldha with an Allosteric Inhibitor (compound 3)
86. 6jml: Re-refined Structure of R-state L-lactate Dehydrogenase Fromlactobacillus Casei
87. 3pqe: Crystal Structure of L-lactate Dehydrogenase from Bacillus Subtilis with H171C Mutation
88. 4a73: Single Point Mutant of Thermus Thermophilus Lactate Dehydrogenase
89. 3pqf: Crystal Structure of L-lactate Dehydrogenase from Bacillus Subtilis Mutation H171C Complexed with Nad+
90. 3pqd: Crystal Structure of L-lactate Dehydrogenase from Bacillus Subtilis Complexed with Fbp and Nad+
91. 3zzn: 5-mutant (R79W, R151A, E279A, E299A,E313A) Lactate-dehydrogenase from Thermus Thermophillus
92. 4aj1: Rat Ldha in Complex with N-(2-(methylamino)-1,3- Benzothiazol-6-yl)acetamide
93. 4aj2: Rat Ldha in Complex with 5-(2-chlorophenyl)-1h-tetrazole
94. 4aj4: Rat Ldha in Complex with 4-((2-allylsulfanyl-1,3-benzothizol-6-yl) Amino)-4-oxo-butanoic Acid
95. 4aje: Rat Ldha in Complex with 2-(4-bromophenoxy)propanedioic Acid
96. 4ajh: Rat Ldha in Complex with N-(2-methyl-1,3-benzothiazol-6-yl)-3-ureido- Propanamide and 2-(4-bromophenoxy)propanedioic Acid
97. 4aji: Rat Ldha in Complex with 2-((3,4-dimethoxyphenyl)methyl)) Propanedioic Acid
98. 4ajj: Rat Ldha in Complex with 2-((3,4-dimethoxyphenyl)methyl)) Propanedioic Acid and N-(2-methyl-1,3-benzothiazol-6-yl)-3- Ureido-propanamide
99. 4ajk: Rat Ldha in Complex with N-(2-(methylamino)-1,3-benzothiazol-6-yl) Acetamide
100. 4ajl: Rat Ldha in Complex with 3-(ethylcarbamoylamino)-n-(2-methyl-1,3- Benzothiazol-6-yl)propanamide
101. 4ajn: Rat Ldha in Complex with 2-((4-(2-((3-((2-methyl-1,3- Benzothiazol-6-yl)amino)-3-oxo-propyl)carbamoylamino)ethyl) Phenyl)methyl)propanedioic Acid
102. 4ajo: Rat Ldha in Complex with 2-((4-(4-((3-((2-methyl-1,3- Benzothiazol-6yl)amino)-3-oxo-propyl)amino)-4-oxo-butyl) Phenyl)methyl)propanedioic Acid
103. 4ajp: Human Ldha in Complex with 2-((4-(4-((3-((2-methyl-1,3- Benzothiazol-6yl)amino)-3-oxo-propyl)amino)-4-oxo-butyl) Phenyl)methyl)propanedioic Acid
104. 4al4: Rat Ldha in Complex with 2-((4-(2-((3-((2-methyl-1,3-benzothiazol-6- Yl)amino)3-oxo-propyl)carbamoylamino)ethoxy) Phenyl) Methylpropanedioic Acid
105. 6mva: Ldha Structure in Complex with Inhibitor 14
106. 6mv8: Ldha Structure in Complex with Inhibitor 14
107. 6k13: Crystal Structure Basis for Bmldh Complex
108. 6k12: Babesia Microti Lactate Dehydrogenase Apo Form (bmldh)
109. 6j9u: Complex Structure of Lactobacillus Casei Lactate Dehydrogenase Penta Mutant with Pyruvate
110. 6j9t: Complex Structure of Lactobacillus Casei Lactate Dehydrogenase with Fructose-1,6-bisphosphate
111. 6j9s: Penta Mutant of Lactobacillus Casei Lactate Dehydrogenase
112. 6j9d: Babesia Microti Lactate Dehydrogenase R99A (BMLDHR99A)
113. 4b7u: Plasmodium Falciparum L-lactate Dehydrogenase Complexed with Bicine
114. 4i8x: Crystal Structure of Rabbit Ldha in Complex with Ap27460
115. 4i9h: Crystal Structure of Rabbit Ldha in Complex with Ap28669
116. 4i9n: Crystal Structure of Rabbit Ldha in Complex with Ap28161 and Ap28122
117. 4i9u: Crystal Structure of Rabbit Ldha in Complex with a Fragment Inhibitor Ap26256
118. 6h9s: Crystal Dimeric Structure of Petrotoga Mobilis Lactate Dehydrogenase with Nadh
119. 3vpg: L-lactate Dehydrogenase from Thermus Caldophilus Gk24
120. 3vph: L-lactate Dehydrogenase from Thermus Caldophilus Gk24 Complexed with Oxamate, Nadh and Fbp
121. 4jnk: Lactate Dehydrogenase a in Complex with Inhibitor Compound 22
122. 4ln1: Crystal Structure of L-lactate Dehydrogenase from Bacillus Cereus Atcc 14579 Complexed with Calcium, Nysgrc Target 029452
123. 4lmr: Crystal Structure of L-lactate Dehydrogenase from Bacillus Cereus Atcc 14579, Nysgrc Target 029452
124. 3wsv: Crystal Structure of Minor L-lactate Dehydrogenase from Enterococcus Mundtii in The Ligands-unbound Form
125. 3wsw: Crystal Structure of Minor L-lactate Dehydrogenase from Enterococcus Mundtii in The Ligands-bound Form
126. 3zh2: Structure of Plasmodium Falciparum Lactate Dehydrogenase in Complex with a Dna Aptamer
127. 6cep: Sus Scrofa Heart L-lactate Dehydrogenase Ternary Complex with Nadh and Oxamate
128. 4l4r: Structural Characterisation of The Apo-form of Human Lactate Dehydrogenase M Isozyme
129. 4l4s: Structural Characterisation of The Nadh Binary Complex of Human Lactate Dehydrogenase M Isozyme
130. 4m1q: Crystal Structure of L-lactate Dehydrogenase from Bacillus Selenitireducens Mls10, Nysgrc Target 029814.
131. 4m49: Lactate Dehydrogenase a in Complex with a Substituted Pyrazine Inhibitor Compound 18
132. 4plz: Crystal Structure of Plasmodium Falciparum Lactate Dehydrogenase Mutant W107FA.
133. 5w8l: Crystal Structure of Lactate Dehydrogenase a in Complex with Inhibitor Compound 59 and Nadh
134. 5w8k: Crystal Structure of Lactate Dehydrogenase a in Complex with Inhibitor Compound 29 and Nadh
135. 5w8j: Crystal Structure of Lactate Dehydrogenase a in Complex with Inhibitor Compound 29
136. 5w8i: Crystal Structure of Lactate Dehydrogenase a in Complex with Inhibitor Compound 23 and Zinc
137. 5w8h: Crystal Structure of Lactate Dehydrogenase a in Complex with Inhibitor Compound 11
138. 4qo7: Lactate Dehydrogenase a in Complex with Substituted 3-hydroxy-2- Mercaptocyclohex-2-enone Compound 7
139. 4qo8: Lactate Dehydrogenase a in Complex with Substituted 3-hydroxy-2- Mercaptocyclohex-2-enone Compound 104
140. 4rls: Lactate Dehydrogenase in Complex with Inhibitor Compound 47
141. 4ojn: Crystal Structure of Human Muscle L-lactate Dehydrogenase
142. 4okn: Crystal Structure of Human Muscle L-lactate Dehydrogenase, Ternary Complex with Nadh and Oxalate
143. 4qsm: Crystal Structure of Human Muscle L-lactate Dehydrogenase in Complex with Inhibitor 2, 3-{[7-(2,4-dimethoxypyrimidin-5-yl)-3- Sulfamoylquinolin-4-yl]amino}benzoic Acid
144. 4qt0: Crystal Structure of Human Muscle L-lactate Dehydrogenase in Complex with Inhibitor 1, 3-{[3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl) Quinolin-4-yl]amino}benzoic Acid
145. 4nd1: Crystal Structure of The Lactate Dehydrogenase from Cryptosporidium Parvum Complexed with Cofactor (b-nicotinamide Adenine Dinucleotide) and Inhibitor (oxamic Acid)
146. 4nd2: Crystal Structure of The Lactate Dehydrogenase from Cryptosporidium Parvum Complexed with Substrate (pyruvic Acid) and Cofactor Analog (3-acetylpyridine Adenine Dinucleotide)
147. 4nd3: Crystal Structure of The Lactate Dehydrogenase from Cryptosporidium Parvum Complexed with Substrate (l-lactic Acid) and Cofactor (b- Nicotinamide Adenine Dinucleotide)
148. 4nd4: Crystal Structure of The Lactate Dehydrogenase from Cryptosporidium Parvum Complexed with Substrate (pyruvic Acid) and Cofactor (b- Nicotinamide Adenine Dinucleotide)
149. 4nd5: Crystal Structure of The Lactate Dehydrogenase from Cryptosporidium Parvum
150. 5nqq: Rabbit Muscle L-lactate Dehydrogenase in Complex with Nadh and Oxaloacetate
151. 5nqb: Rabbit Muscle L-lactate Dehydrogenase in Complex with Malonate
152. 5kkc: L-lactate Dehydrogenase from Rabbit Muscle with The Inhibitor 6dhnad
153. 5k0z: Cryo-em Structure of Lactate Dehydrogenase (ldh) in Inhibitor-bound State
154. 5ixy: Lactate Dehydrogenase in Complex with Hydroxylactam Inhibitor Compound 31: (2~{s})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4- Oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one
155. 5ixs: Lactate Dehydrogenase in Complex with Hydroxylactam Inhibitor Compound 9: (6r)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6- (thiophen-3-yl)-5,6-dihydropyridin-2(1h)-one
156. 5hto: Crystal Structure of Plasmodium Vivax Ldh in Complex with a Dna Aptamer Called Pl1 (tetrameric Ldh in an Asymmetric Unit)
157. 5hs4: Plasmdoium Vivax Lactate Dehydrogenase
158. 5hru: Crystal Structure of Plasmodium Vivax Ldh in Complex with a Dna Aptamer Called Pl1
159. 5es3: Co-crystal Structure of Ldh Liganded with Oxamate
160. 4r68: Lactate Dehydrogenase in Complex with Inhibitor Compound 31
161. 4r69: Lactate Dehydrogenase in Complex with Inhibitor Compound 13
162. 5a1t: Trichomonas Vaginalis Lactate Dehydrogenase in Complex with Nadh and Oxamate
163. 4zvv: Lactate Dehydrogenase a in Complex with a Trisubstituted Piperidine-2, 4-dione Inhibitor Gne-140
164. 4uul: Apo Trichomonas Vaginalis Lactate Dehydrogenase L91R
165. 4uum: Apo Trichomonas Vaginalis Lactate Dehydrogenase
166. 4uun: Trichomonas Vaginalis Lactate Dehydrogenase in Complex with Nadh
167. 7nay: Crystal Structure of Lactate Dehydrogenase from Selenomonas Ruminantium with Nadh.
168. 7m2n: Crystal Structure of Human Lactate Dehydrogenase a with Inhibitor Compound 15
169. 7dbj: Crystal Structure of Human Ldhb in Complex with Nadh, Oxamate, and Axko-0046
170. 7dbk: Crystal Structure of Human Ldhb in Complex with Nadh