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enzyme (lysozyme)

 
Enzymes
  Enzyme classes:
  EC 1: Oxidoreductases
    EC 1.1
      EC 1.1.1
        EC 1.1.1.1
        EC 1.1.1.2
        EC 1.1.1.3
        EC 1.1.1.4
        EC 1.1.1.5
        EC 1.1.1.6
        EC 1.1.1.7
        EC 1.1.1.8
        EC 1.1.1.9
        EC 1.1.1.10
        EC 1.1.1.11
        EC 1.1.1.12
        EC 1.1.1.13
        EC 1.1.1.14
        EC 1.1.1.15
        EC 1.1.1.16
        EC 1.1.1.17
        EC 1.1.1.18
        EC 1.1.1.19
        EC 1.1.1.20
        EC 1.1.1.21
        EC 1.1.1.22
        EC 1.1.1.23
        EC 1.1.1.24
        EC 1.1.1.25
        EC 1.1.1.26
        EC 1.1.1.27
        EC 1.1.1.28
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      EC 1.1.2
      EC 1.1.3
      EC 1.1.4
      EC 1.1.5
      EC 1.1.99
    EC 1.2
    EC 1.3
    EC 1.4
    EC 1.5
    EC 1.6
    EC 1.7
    EC 1.8
    EC 1.9
    EC 1.10
    EC 1.11
    EC 1.12
    EC 1.13
    EC 1.14
    EC 1.15
    EC 1.16
    EC 1.17
    EC 1.18
    EC 1.19
    EC 1.20
    EC 1.21
    EC 1.97
    EC 1.98
    EC 1.99
  EC 2: Transferases
  EC 3: Hydrolases
  EC 4: Lyases
  EC 5: Isomerases
  EC 6: Ligases
  General information:
  Catalytic mechanism
  Enzyme kinetics
  Inhibitors
  Enzymes in industry

EC 1.1.1.21 - alditol:NAD(P) + 1- oxidoreductase (aldehyde reductase)



3D structures of EC 1.1.1.21 - aldehyde reductase in Protein Data Bank

updated: 22 January 2021, 10:45

In total: 167 PDB structures of EC 1.1.1.21 - aldehyde reductase:
  1. 1abn: The Crystal Structure of The Aldose Reductase Nadph Binary Complex
  2. 1ads: An Unlikely Sugar Substrate Site in The 1.65 Angstroms Structure of The Human Aldose Reductase Holoenzyme Implicated in Diabetic Complications
  3. 1ah0: Pig Aldose Reductase Complexed with Sorbinil
  4. 1ah3: Aldose Reductase Complexed with Tolrestat Inhibitor
  5. 1ah4: Pig Aldose Reductase, Holo Form
  6. 1az1: Alrestatin Bound to C298A/W219Y Mutant Human Aldose Reductase
  7. 1az2: Citrate Bound, C298A/W219Y Mutant Human Aldose Reductase
  8. 1dla: Novel Nadph-binding Domain Revealed by The Crystal Structure of Aldose Reductase
  9. 1ef3: Fidarestat Bound to Human Aldose Reductase
  10. 1eko: Pig Aldose Reductase Complexed with Idd384 Inhibitor
  11. 1el3: Human Aldose Reductase Complexed with Idd384 Inhibitor
  12. 1iei: Crystal Structure of Human Aldose Reductase Complexed with The Inhibitor Zenarestat.
  13. 1jez: The Structure of Xylose Reductase, a Dimeric Aldo-keto Reductase from Candida Tenuis
  14. 1k8c: Crystal Structure of Dimeric Xylose Reductase in Complex with Nadp(h)
  15. 1mar: Refined 1.8 Angstroms Structure of Human Aldose Reductase Complexed with The Potent Inhibitor Zopolrestat
  16. 1mi3: 1.8 Angstrom Structure of Xylose Reductase from Candida Tenuis in Complex with Nadh
  17. 3krb: Structure of Aldose Reductase from Giardia Lamblia at 1.75a Resolution
  18. 1pwl: Crystal Structure of Human Aldose Reductase Complexed with Nadp and Minalrestat
  19. 1pwm: Crystal Structure of Human Aldose Reductase Complexed with Nadp and Fidarestat
  20. 1r38: Crystal Structure of H114A Mutant of Candida Tenuis Xylose Reductase
  21. 3ghu: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Idd594. Investigation of Global Effects of Radiation Damage on Protein Structure. Forth Stage of Radiation Damage.
  22. 3ght: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Idd594. Investigation of Global Effects of Radiation Damage on Protein Structure. Third Stage of Radiation Damage.
  23. 3ghs: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Idd594. Investigation of Global Effects of Radiation Damage on Protein Structure. Second Stage of Radiation Damage.
  24. 3ghr: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Idd594. Investigation of Global Effects of Radiation Damage on Protein Structure. First Stage of Radiation Damage
  25. 3g5e: Human Aldose Reductase Complexed with Idd 740 Inhibitor
  26. 1sm9: Crystal Structure of an Engineered K274RN276D Double Mutant of Xylose Reductase from Candida Tenuis Optimized to Utilize Nad
  27. 1t40: Crystal Structure of Human Aldose Reductase Complexed with Nadp and Idd552 at Ph 5
  28. 1t41: Crystal Structure of Human Aldose Reductase Complexed with Nadp and Idd552
  29. 3dn5: Aldose Reductase in Complex with Novel Biarylic Inhibitor
  30. 1us0: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Idd594 at 0.66 Angstrom
  31. 3bcj: Crystal Structure of Aldose Reductase Complexed with 2S4R (stereoisomer of Fidarestat, 2S4S) at 0.78 a
  32. 1x96: Crystal Structure of Aldose Reductase with Citrates Bound in The Active Site
  33. 1x97: Crystal Structure of Aldose Reductase Complexed with 2R4S (stereoisomer of Fidarestat, 2S4S)
  34. 1x98: Crystal Structure of Aldose Reductase Complexed with 2S4R (stereoisomer of Fidarestat, 2S4S)
  35. 1xgd: Apo R268A Human Aldose Reductase
  36. 1z3n: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Lidorestat at 1.04 Angstrom
  37. 1z89: Human Aldose Reductase Complexed with Novel Sulfonyl- Pyridazinone Inhibitor
  38. 1z8a: Human Aldose Reductase Complexed with Novel Sulfonyl- Pyridazinone Inhibitor
  39. 2vdg: Barley Aldose Reductase 1 Complex with Butanol
  40. 2acq: An Anion Binding Site in Human Aldose Reductase: Mechanistic Implications for The Binding of Citrate, Cacodylate, and Glucose-6-phosphate
  41. 2acr: An Anion Binding Site in Human Aldose Reductase: Mechanistic Implications for The Binding of Citrate, Cacodylate, and Glucose-6-phosphate
  42. 2acs: An Anion Binding Site in Human Aldose Reductase: Mechanistic Implications for The Binding of Citrate, Cacodylate, and Glucose-6-phosphate
  43. 2acu: Tyrosine-48 Is The Proton Donor and Histidine-110 Directs Substrate Stereochemical Selectivity in The Reduction Reaction of Human Aldose Reductase: Enzyme Kinetics and The Crystal Structure of The Y48H Mutant Enzyme
  44. 2agt: Aldose Reductase Mutant Leu 300 pro Complexed with Fidarestat
  45. 2bgq: Apo Aldose Reductase from Barley
  46. 2bgs: Holo Aldose Reductase from Barley
  47. 2r24: Human Aldose Reductase Structure
  48. 2qxw: Perdeuterated Alr2 in Complex with Idd594
  49. 2pzn: The Crystallographic Structure of Aldose Reductase Idd393 Complex Confirms Leu300 as a Specificity Determinant
  50. 2pfh: Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and Idd594. Concentration of Fidarestat in Soaking Solution Is less than Concentration of Idd594.
  51. 2pf8: Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and Idd594. Concentration of Fidarestat in Soaking Solution Is Equal to Concentration of Idd594.
  52. 2pev: Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and Idd594. Concentration of Fidarestat in Soaking Solution Exceeds Concentration of Idd594.
  53. 2pdy: Human Aldose Reductase Double Mutant S302R-C303D Complexed with Fidarestat.
  54. 2pdx: Human Aldose Reductase Double Mutant S302R-C303D Complexed with Zopolrestat.
  55. 2pdw: Human Aldose Reductase Mutant C303D Complexed with Fidarestat.
  56. 2pdu: Human Aldose Reductase Mutant C303D Complexed with Idd393.
  57. 2pdq: Human Aldose Reductase Mutant C303D Complexed with Uracil- Type Inhibitor.
  58. 2pdp: Human Aldose Reductase Mutant S302R Complexed with Idd 393.
  59. 2pdn: Human Aldose Reductase Mutant S302R Complexed with Uracil- Type Inhibitor.
  60. 2pdm: Human Aldose Reductase Mutant S302R Complexed with Zopolrestat.
  61. 2pdl: Human Aldose Reductase Mutant L301M Complexed with Tolrestat.
  62. 2pdk: Human Aldose Reductase Mutant L301M Complexed with Sorbinil.
  63. 2pdj: Human Aldose Reductase Mutant L300A Complexed with Idd393.
  64. 2pdi: Human Aldose Reductase Mutant L300A Complexed with Zopolrestat at 1.55 A.
  65. 2pdh: Human Aldose Reductase Mutant L300P Complexed with Uracil- Type Inhibitor at 1.45 A.
  66. 2pdg: Human Aldose Reductase with Uracil-type Inhibitor at 1.42a.
  67. 2pdf: Human Aldose Reductase Mutant L300P Complexed with Zopolrestat.
  68. 2pdc: Human Aldose Reductase Mutant F121P Complexed with Idd393.
  69. 2pdb: Human Aldose Reductase Mutant F121P Complexed with Zopolrestat.
  70. 2pd9: Human Aldose Reductase Mutant V47I Complexed with Fidarestat.
  71. 2pd5: Human Aldose Reductase Mutant V47I Complexed with Zopolrestat
  72. 2dux: Crystal Structure of Human Aldose Reductase Complexed with Zopolrestat after 3 Days Soaking (3days_soaked_1)
  73. 2duz: Human Aldose Reductase Complexed with Inhibitor Zopolrestat after 3 Days Soaking (3days_soaked_2)
  74. 2dv0: Human Aldose Reductase Complexed with Zopolrestat after 6 Days Soaking(6days_soaked_2)
  75. 2nvd: Human Aldose Reductase Complexed with Novel Naphtho[1,2- D]isothiazole Acetic Acid Derivative (2)
  76. 2nvc: Human Aldose Reductase Complexed with Novel Naphtho[1,2- D]isothiazole Acetic Acid Derivative (3)
  77. 2f2k: Aldose Reductase Tertiary Complex with Nadph and Deg
  78. 2fz8: Human Aldose Reductase Complexed with Inhibitor Zopolrestat at 1.48 A(1 Day Soaking).
  79. 2fz9: Human Aldose Reductase Complexed with Inhibitor Zopolrestat after Six Days Soaking.
  80. 2fzb: Human Aldose Reductase Complexed with Four Tolrestat Molecules at 1.5 a Resolution.
  81. 2fzd: Human Aldose Reductase Complexed with Tolrestat at 1.08 a Resolution.
  82. 5zcm: Crystal Structure of Xylose Reductase from Debaryomyces Nepalensis in Complex with Nadp-dtt Adduct
  83. 5zci: Crystal Structure of Apo Form of Xylose Reductase from Debaryomyces Nepalensis
  84. 2hv5: Human Aldose Reductase Complexed with Inhibitor Zopolrestat after Three Days Soaking (3days_soaked_3)
  85. 2hvn: Human Aldose Reductase-zopolrestat Complex Obtained by Cocrystallisation after One Day (1day_cocryst)
  86. 2hvo: Human Aldose Reductase-zopolrestat Complex Obtained by Cocrystallisation (10days_cocryst)
  87. 2i16: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Idd594 at Temperature of 15k
  88. 2i17: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Idd594 at Temperature of 60k
  89. 2ikg: Aldose Reductase Complexed with Nitrophenyl-oxadiazol Type Inhibitor at 1.43 a
  90. 2ikh: Human Aldose Reductase Complexed with Nitrofuryl-oxadiazol Inhibitor at 1.55 a
  91. 2iki: Human Aldose Reductase Complexed with Halogenated Idd-type Inhibitor
  92. 2ikj: Human Aldose Reductase Complexed with Nitro-substituted Idd- Type Inhibitor
  93. 2ine: Crystal Structure of Aldose Reductase Complexed with Phenylacetic Acid
  94. 2inz: Crystal Structure of Aldose Reductase Complexed with 2- Hydroxyphenylacetic Acid
  95. 2ipw: Crystal Structure of C298A W219Y Aldose Reductase Complexed with Dichlorophenylacetic Acid
  96. 2iq0: Crystal Structure of Aldose Reductase Complexed with Hexanoic Acid
  97. 2iqd: Crystal Structure of Aldose Reductase Complexed with Lipoic Acid
  98. 2is7: Crystal Structure of Aldose Reductase Complexed with Dichlorophenylacetic Acid
  99. 2isf: Crystal Structure of C298A W219Y Aldose Reductase Complexed with Phenylacetic Acid
  100. 2j8t: Human Aldose Reductase in Complex with Nadp and Citrate at 0.82 Angstrom
  101. 6td8: Human Aldose Reductase Mutant L301A in Complex with a Ligand with an Idd Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic Acid)
  102. 6t7q: Human Aldose Reductase Mutant L301A in Complex with a Ligand with an Idd Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl) Benzoic Acid)
  103. 6t5g: Structure of Human Aldose Reductase Mutant L300A with a Citrate Molecule Bound in The Anion Binding Pocket
  104. 6t3p: Human Aldose Reductase Mutant L300A in Complex with a Ligand with an Idd Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic Acid)
  105. 6t27: Structure of Human Aldose Reductase Mutant L301A with a Citrate Molecule Bound in The Anion Binding Pocket
  106. 6syw: Human Aldose Reductase in Complex with Sar25
  107. 3lbo: Human Aldose Reductase Mutant T113C Complexed with Idd594
  108. 3ld5: Human Aldose Reductase Mutant T113S Complexed with Idd594
  109. 3len: Human Aldose Reductase Mutant T113S Complexed with Zopolrestat
  110. 3lep: Human Aldose Reductase Mutant T113C in Complex with Idd388
  111. 3lqg: Human Aldose Reductase Mutant T113A Complexed with Idd388
  112. 3lql: Human Aldose Reductase Mutant T113A Complexed with Idd 594
  113. 3lz3: Human Aldose Reductase Mutant T113S Complexed with Idd388
  114. 3lz5: Human Aldose Reductase Mutant T113V Complexed with Idd594
  115. 3m4h: Human Aldose Reductase Mutant T113V Complexed with Idd388
  116. 3q65: Human Aldose Reductase in Complex with Nadp+ in Space Group P212121
  117. 3q67: Human Aldose Reductase C298S Mutant in Complex with Nadp+ in Space Group P212121
  118. 3m0i: Human Aldose Reductase Mutant T113V in Complex with Zopolrestat
  119. 3m64: Human Aldose Reductase Mutant T113V Complexed with Idd393
  120. 3mb9: Human Aldose Reductase Mutant T113A Complexed with Zopolrestat
  121. 3mc5: Human Aldose Reductase Mutant T113V in Complex with Idd393 Crystallized in Spacegroup P1
  122. 3onb: Bond Breakage and Relocation of a Covalently Bound Bromine of Idd594 in a Complex with Har T113A Mutant after Extensive Radiation Dose
  123. 3onc: Bond Breakage and Relocation of a Covalently Bound Bromine of Idd594 in a Complex with Har T113A Mutant after Moderate Radiation Dose
  124. 3p2v: Novel Benzothiazepine Inhibitor in Complex with Human Aldose Reductase
  125. 3t42: Human Aldose Reductase in Complex with a Nitrile-containing Idd Inhibitor
  126. 3u2c: Aldose Reductase in Complex with Nsaid-type Inhibitor at 1.0 a Resolution
  127. 3rx2: Crystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfone
  128. 3rx3: Crystal Structure of Human Aldose Reductase Complexed with Sulindac
  129. 3rx4: Crystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfide
  130. 3s3g: Crystal Structure of Human Aldose Reductase Complexed with Tolmetin
  131. 3v35: Aldose Reductase Complexed with a Nitro Compound
  132. 3v36: Aldose Reductase Complexed with Glceraldehyde
  133. 4hbk: Structure of The Aldose Reductase from Schistosoma Japonicum
  134. 6f8o: AKR1B1 at 3.45 Mgy Radiation Dose.
  135. 6f84: AKR1B1 at 2.55 Mgy Radiation Dose.
  136. 6f82: AKR1B1 at 1.65 Mgy Radiation Dose.
  137. 6f81: AKR1B1 at 0.75 Mgy Radiation Dose.
  138. 6f7r: AKR1B1 at 0.03 Mgy Radiation Dose.
  139. 4gca: Complex of Aldose Reductase with Inhibitor Idd 1219
  140. 4igs: Crystal Structure of Human Aldose Reductase Complexed with Nadp+ and Jf0064
  141. 4jir: Crystal Structure of Aldose Reductase (AKR1B1) Complexed with Nadp+ and Epalrestat
  142. 4lau: Crystal Structure of Human Ar Complexed with Nadp+ and {2-[(4- Bromobenzyl)carbamoyl]-5-chlorophenoxy}acetic Acid
  143. 4laz: Crystal Structure of Human Ar Complexed with Nadp+ and {5-chloro-2- [(4-iodobenzyl)carbamoyl]phenoxy}acetic Acid
  144. 4lb3: Crystal Structure of Human Ar Complexed with Nadp+ and {5-chloro-2- [(2-fluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic Acid
  145. 4lb4: Crystal Structure of Human Ar Complexed with Nadp+ and {2-[(4-bromo-2, 3,5,6-tetrafluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic Acid
  146. 4lbr: Crystal Structure of Human Ar Complexed with Nadp+ and {5-chloro-2- [(2,6-difluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic Acid
  147. 4lbs: Crystal Structure of Human Ar Complexed with Nadp+ and {2-[(4-bromo-2, 6-difluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic Acid
  148. 5ouk: Crystal Structure of Human AKR1B1 Complexed with Nadp+ and Compound 41
  149. 5ouj: Crystal Structure of Human AKR1B1 Complexed with Nadp+ and Compound 39
  150. 5ou0: Crystal Structure of Human AKR1B1 Complexed with Nadp+ and Compound 37
  151. 5ha7: Human Aldose Reductase in Complex with Nadp+ and Wy14643 in Space Group P212121
  152. 4nkc: Human Aldose Reductase Complexed with Schl7764 at 1.12 a
  153. 4qx4: Human Aldose Reductase Complexed with a Ligand with a New Scaffold at 1.26 a
  154. 4pr4: Human Aldose Reductase Complexed with Schl7802 at 1.06 a
  155. 4prr: Human Aldose Reductase Complexed with Schl7815 ((3-[3-(5-nitrofuran-2- Yl)phenyl]propanoic Acid)at 1.01 a
  156. 4prt: Human Aldose Reductase Complexed with Schl12221 ({2-[5-(3- Nitrophenyl)furan-2-yl]phenyl}acetic Acid) at 0.96 a
  157. 4puu: Human Aldose Reductase Complexed with a Ligand with an Idd Structure (2-(2-carbamoyl-5-fluoro-phenoxy)acetic Acid) at 1.14 a
  158. 4puw: Human Aldose Reductase Complexed with a Ligand with an Idd Structure (2-[5-fluoro-2-(prop-2-ynylcarbamoyl)phenoxy]acetic Acid) at 1.12 a
  159. 4yu1: Human Aldose Reductase Complexed with Schl12134 (3-[5-(3-nitrophenyl)- 2-thienyl]propanoic Acid) at 1.02 a
  160. 4ys1: Human Aldose Reductase Complexed with a Ligand with an Idd Structure (2) at 1.07 A.
  161. 4q7b: Human Aldose Reductase Complexed with a Ligand with an Idd Structure ([2-(benzylcarbamoyl)-5-fluorophenoxy]acetic Acid) at 1.19 a
  162. 4qbx: Human Aldose Reductase Complexed with a Ligand with an Idd Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic Acid) at 0.98 a
  163. 4qr6: Human Aldose Reductase Complexed with a Ligand with an Idd Structure (2-[2-(1,3-benzothiazol-2-ylmethylcarbamoyl)-5-fluoro-phenoxy]acetic Acid) at 1.05 a
  164. 4qxi: Crystal Structure of Human Ar Complexed with Nadp+ and Ak198
  165. 4rpq: Human Aldose Reductase Complexed with a Ligand with an Idd Structure at 1.20 a (1)
  166. 4xzh: Crystal Structure of Human Aldose Reductase Complexed with Nadp+ and Jf0048
  167. 4xzi: Crystal Structure of Human Aldose Reductase Complexed with Nadp+ and Jf0049
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