EC 1.1.1.21 - alditol:NAD(P) ⁺ 1- oxidoreductase (aldehyde reductase)

3D structures of EC 1.1.1.21 - aldehyde reductase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1abn: The Crystal Structure of The Aldose Reductase Nadph Binary Complex
2. 1ads: An Unlikely Sugar Substrate Site in The 1.65 Angstroms Structure of The Human Aldose Reductase Holoenzyme Implicated in Diabetic Complications
3. 1ah0: Pig Aldose Reductase Complexed with Sorbinil
4. 1ah3: Aldose Reductase Complexed with Tolrestat Inhibitor
5. 1ah4: Pig Aldose Reductase, Holo Form
6. 1az1: Alrestatin Bound to C298A/W219Y Mutant Human Aldose Reductase
7. 1az2: Citrate Bound, C298A/W219Y Mutant Human Aldose Reductase
8. 1dla: Novel Nadph-binding Domain Revealed by The Crystal Structure of Aldose Reductase
9. 1ef3: Fidarestat Bound to Human Aldose Reductase
10. 1eko: Pig Aldose Reductase Complexed with Idd384 Inhibitor
11. 1el3: Human Aldose Reductase Complexed with Idd384 Inhibitor
12. 1iei: Crystal Structure of Human Aldose Reductase Complexed with The Inhibitor Zenarestat.
13. 1jez: The Structure of Xylose Reductase, a Dimeric Aldo-keto Reductase from Candida Tenuis
14. 1k8c: Crystal Structure of Dimeric Xylose Reductase in Complex with Nadp(h)
15. 1mar: Refined 1.8 Angstroms Structure of Human Aldose Reductase Complexed with The Potent Inhibitor Zopolrestat
16. 1mi3: 1.8 Angstrom Structure of Xylose Reductase from Candida Tenuis in Complex with Nadh
17. 3krb: Structure of Aldose Reductase from Giardia Lamblia at 1.75a Resolution
18. 1pwl: Crystal Structure of Human Aldose Reductase Complexed with Nadp and Minalrestat
19. 1pwm: Crystal Structure of Human Aldose Reductase Complexed with Nadp and Fidarestat
20. 1r38: Crystal Structure of H114A Mutant of Candida Tenuis Xylose Reductase
21. 3ghu: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Idd594. Investigation of Global Effects of Radiation Damage on Protein Structure. Forth Stage of Radiation Damage.
22. 3ght: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Idd594. Investigation of Global Effects of Radiation Damage on Protein Structure. Third Stage of Radiation Damage.
23. 3ghs: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Idd594. Investigation of Global Effects of Radiation Damage on Protein Structure. Second Stage of Radiation Damage.
24. 3ghr: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Idd594. Investigation of Global Effects of Radiation Damage on Protein Structure. First Stage of Radiation Damage
25. 3g5e: Human Aldose Reductase Complexed with Idd 740 Inhibitor
26. 1sm9: Crystal Structure of an Engineered K274RN276D Double Mutant of Xylose Reductase from Candida Tenuis Optimized to Utilize Nad
27. 1t40: Crystal Structure of Human Aldose Reductase Complexed with Nadp and Idd552 at Ph 5
28. 1t41: Crystal Structure of Human Aldose Reductase Complexed with Nadp and Idd552
29. 3dn5: Aldose Reductase in Complex with Novel Biarylic Inhibitor
30. 1us0: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Idd594 at 0.66 Angstrom
31. 3bcj: Crystal Structure of Aldose Reductase Complexed with 2S4R (stereoisomer of Fidarestat, 2S4S) at 0.78 a
32. 1x96: Crystal Structure of Aldose Reductase with Citrates Bound in The Active Site
33. 1x97: Crystal Structure of Aldose Reductase Complexed with 2R4S (stereoisomer of Fidarestat, 2S4S)
34. 1x98: Crystal Structure of Aldose Reductase Complexed with 2S4R (stereoisomer of Fidarestat, 2S4S)
35. 1xgd: Apo R268A Human Aldose Reductase
36. 1z3n: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Lidorestat at 1.04 Angstrom
37. 1z89: Human Aldose Reductase Complexed with Novel Sulfonyl- Pyridazinone Inhibitor
38. 1z8a: Human Aldose Reductase Complexed with Novel Sulfonyl- Pyridazinone Inhibitor
39. 2vdg: Barley Aldose Reductase 1 Complex with Butanol
40. 2acq: An Anion Binding Site in Human Aldose Reductase: Mechanistic Implications for The Binding of Citrate, Cacodylate, and Glucose-6-phosphate
41. 2acr: An Anion Binding Site in Human Aldose Reductase: Mechanistic Implications for The Binding of Citrate, Cacodylate, and Glucose-6-phosphate
42. 2acs: An Anion Binding Site in Human Aldose Reductase: Mechanistic Implications for The Binding of Citrate, Cacodylate, and Glucose-6-phosphate
43. 2acu: Tyrosine-48 Is The Proton Donor and Histidine-110 Directs Substrate Stereochemical Selectivity in The Reduction Reaction of Human Aldose Reductase: Enzyme Kinetics and The Crystal Structure of The Y48H Mutant Enzyme
44. 2agt: Aldose Reductase Mutant Leu 300 pro Complexed with Fidarestat
45. 2bgq: Apo Aldose Reductase from Barley
46. 2bgs: Holo Aldose Reductase from Barley
47. 2r24: Human Aldose Reductase Structure
48. 2qxw: Perdeuterated Alr2 in Complex with Idd594
49. 2pzn: The Crystallographic Structure of Aldose Reductase Idd393 Complex Confirms Leu300 as a Specificity Determinant
50. 2pfh: Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and Idd594. Concentration of Fidarestat in Soaking Solution Is less than Concentration of Idd594.
51. 2pf8: Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and Idd594. Concentration of Fidarestat in Soaking Solution Is Equal to Concentration of Idd594.
52. 2pev: Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and Idd594. Concentration of Fidarestat in Soaking Solution Exceeds Concentration of Idd594.
53. 2pdy: Human Aldose Reductase Double Mutant S302R-C303D Complexed with Fidarestat.
54. 2pdx: Human Aldose Reductase Double Mutant S302R-C303D Complexed with Zopolrestat.
55. 2pdw: Human Aldose Reductase Mutant C303D Complexed with Fidarestat.
56. 2pdu: Human Aldose Reductase Mutant C303D Complexed with Idd393.
57. 2pdq: Human Aldose Reductase Mutant C303D Complexed with Uracil- Type Inhibitor.
58. 2pdp: Human Aldose Reductase Mutant S302R Complexed with Idd 393.
59. 2pdn: Human Aldose Reductase Mutant S302R Complexed with Uracil- Type Inhibitor.
60. 2pdm: Human Aldose Reductase Mutant S302R Complexed with Zopolrestat.
61. 2pdl: Human Aldose Reductase Mutant L301M Complexed with Tolrestat.
62. 2pdk: Human Aldose Reductase Mutant L301M Complexed with Sorbinil.
63. 2pdj: Human Aldose Reductase Mutant L300A Complexed with Idd393.
64. 2pdi: Human Aldose Reductase Mutant L300A Complexed with Zopolrestat at 1.55 A.
65. 2pdh: Human Aldose Reductase Mutant L300P Complexed with Uracil- Type Inhibitor at 1.45 A.
66. 2pdg: Human Aldose Reductase with Uracil-type Inhibitor at 1.42a.
67. 2pdf: Human Aldose Reductase Mutant L300P Complexed with Zopolrestat.
68. 2pdc: Human Aldose Reductase Mutant F121P Complexed with Idd393.
69. 2pdb: Human Aldose Reductase Mutant F121P Complexed with Zopolrestat.
70. 2pd9: Human Aldose Reductase Mutant V47I Complexed with Fidarestat.
71. 2pd5: Human Aldose Reductase Mutant V47I Complexed with Zopolrestat
72. 2dux: Crystal Structure of Human Aldose Reductase Complexed with Zopolrestat after 3 Days Soaking (3days_soaked_1)
73. 2duz: Human Aldose Reductase Complexed with Inhibitor Zopolrestat after 3 Days Soaking (3days_soaked_2)
74. 2dv0: Human Aldose Reductase Complexed with Zopolrestat after 6 Days Soaking(6days_soaked_2)
75. 2nvd: Human Aldose Reductase Complexed with Novel Naphtho[1,2- D]isothiazole Acetic Acid Derivative (2)
76. 2nvc: Human Aldose Reductase Complexed with Novel Naphtho[1,2- D]isothiazole Acetic Acid Derivative (3)
77. 2f2k: Aldose Reductase Tertiary Complex with Nadph and Deg
78. 2fz8: Human Aldose Reductase Complexed with Inhibitor Zopolrestat at 1.48 A(1 Day Soaking).
79. 2fz9: Human Aldose Reductase Complexed with Inhibitor Zopolrestat after Six Days Soaking.
80. 2fzb: Human Aldose Reductase Complexed with Four Tolrestat Molecules at 1.5 a Resolution.
81. 2fzd: Human Aldose Reductase Complexed with Tolrestat at 1.08 a Resolution.
82. 5zcm: Crystal Structure of Xylose Reductase from Debaryomyces Nepalensis in Complex with Nadp-dtt Adduct
83. 5zci: Crystal Structure of Apo Form of Xylose Reductase from Debaryomyces Nepalensis
84. 2hv5: Human Aldose Reductase Complexed with Inhibitor Zopolrestat after Three Days Soaking (3days_soaked_3)
85. 2hvn: Human Aldose Reductase-zopolrestat Complex Obtained by Cocrystallisation after One Day (1day_cocryst)
86. 2hvo: Human Aldose Reductase-zopolrestat Complex Obtained by Cocrystallisation (10days_cocryst)
87. 2i16: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Idd594 at Temperature of 15k
88. 2i17: Human Aldose Reductase in Complex with Nadp+ and The Inhibitor Idd594 at Temperature of 60k
89. 2ikg: Aldose Reductase Complexed with Nitrophenyl-oxadiazol Type Inhibitor at 1.43 a
90. 2ikh: Human Aldose Reductase Complexed with Nitrofuryl-oxadiazol Inhibitor at 1.55 a
91. 2iki: Human Aldose Reductase Complexed with Halogenated Idd-type Inhibitor
92. 2ikj: Human Aldose Reductase Complexed with Nitro-substituted Idd- Type Inhibitor
93. 2ine: Crystal Structure of Aldose Reductase Complexed with Phenylacetic Acid
94. 2inz: Crystal Structure of Aldose Reductase Complexed with 2- Hydroxyphenylacetic Acid
95. 2ipw: Crystal Structure of C298A W219Y Aldose Reductase Complexed with Dichlorophenylacetic Acid
96. 2iq0: Crystal Structure of Aldose Reductase Complexed with Hexanoic Acid
97. 2iqd: Crystal Structure of Aldose Reductase Complexed with Lipoic Acid
98. 2is7: Crystal Structure of Aldose Reductase Complexed with Dichlorophenylacetic Acid
99. 2isf: Crystal Structure of C298A W219Y Aldose Reductase Complexed with Phenylacetic Acid
100. 2j8t: Human Aldose Reductase in Complex with Nadp and Citrate at 0.82 Angstrom
101. 6td8: Human Aldose Reductase Mutant L301A in Complex with a Ligand with an Idd Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic Acid)
102. 6t7q: Human Aldose Reductase Mutant L301A in Complex with a Ligand with an Idd Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl) Benzoic Acid)
103. 6t5g: Structure of Human Aldose Reductase Mutant L300A with a Citrate Molecule Bound in The Anion Binding Pocket
104. 6t3p: Human Aldose Reductase Mutant L300A in Complex with a Ligand with an Idd Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic Acid)
105. 6t27: Structure of Human Aldose Reductase Mutant L301A with a Citrate Molecule Bound in The Anion Binding Pocket
106. 6syw: Human Aldose Reductase in Complex with Sar25
107. 3lbo: Human Aldose Reductase Mutant T113C Complexed with Idd594
108. 3ld5: Human Aldose Reductase Mutant T113S Complexed with Idd594
109. 3len: Human Aldose Reductase Mutant T113S Complexed with Zopolrestat
110. 3lep: Human Aldose Reductase Mutant T113C in Complex with Idd388
111. 3lqg: Human Aldose Reductase Mutant T113A Complexed with Idd388
112. 3lql: Human Aldose Reductase Mutant T113A Complexed with Idd 594
113. 3lz3: Human Aldose Reductase Mutant T113S Complexed with Idd388
114. 3lz5: Human Aldose Reductase Mutant T113V Complexed with Idd594
115. 3m4h: Human Aldose Reductase Mutant T113V Complexed with Idd388
116. 3q65: Human Aldose Reductase in Complex with Nadp+ in Space Group P212121
117. 3q67: Human Aldose Reductase C298S Mutant in Complex with Nadp+ in Space Group P212121
118. 3m0i: Human Aldose Reductase Mutant T113V in Complex with Zopolrestat
119. 3m64: Human Aldose Reductase Mutant T113V Complexed with Idd393
120. 3mb9: Human Aldose Reductase Mutant T113A Complexed with Zopolrestat
121. 3mc5: Human Aldose Reductase Mutant T113V in Complex with Idd393 Crystallized in Spacegroup P1
122. 3onb: Bond Breakage and Relocation of a Covalently Bound Bromine of Idd594 in a Complex with Har T113A Mutant after Extensive Radiation Dose
123. 3onc: Bond Breakage and Relocation of a Covalently Bound Bromine of Idd594 in a Complex with Har T113A Mutant after Moderate Radiation Dose
124. 3p2v: Novel Benzothiazepine Inhibitor in Complex with Human Aldose Reductase
125. 3t42: Human Aldose Reductase in Complex with a Nitrile-containing Idd Inhibitor
126. 3u2c: Aldose Reductase in Complex with Nsaid-type Inhibitor at 1.0 a Resolution
127. 3rx2: Crystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfone
128. 3rx3: Crystal Structure of Human Aldose Reductase Complexed with Sulindac
129. 3rx4: Crystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfide
130. 3s3g: Crystal Structure of Human Aldose Reductase Complexed with Tolmetin
131. 3v35: Aldose Reductase Complexed with a Nitro Compound
132. 3v36: Aldose Reductase Complexed with Glceraldehyde
133. 4hbk: Structure of The Aldose Reductase from Schistosoma Japonicum
134. 6f8o: AKR1B1 at 3.45 Mgy Radiation Dose.
135. 6f84: AKR1B1 at 2.55 Mgy Radiation Dose.
136. 6f82: AKR1B1 at 1.65 Mgy Radiation Dose.
137. 6f81: AKR1B1 at 0.75 Mgy Radiation Dose.
138. 6f7r: AKR1B1 at 0.03 Mgy Radiation Dose.
139. 4gca: Complex of Aldose Reductase with Inhibitor Idd 1219
140. 4igs: Crystal Structure of Human Aldose Reductase Complexed with Nadp+ and Jf0064
141. 4jir: Crystal Structure of Aldose Reductase (AKR1B1) Complexed with Nadp+ and Epalrestat
142. 4lau: Crystal Structure of Human Ar Complexed with Nadp+ and {2-[(4- Bromobenzyl)carbamoyl]-5-chlorophenoxy}acetic Acid
143. 4laz: Crystal Structure of Human Ar Complexed with Nadp+ and {5-chloro-2- [(4-iodobenzyl)carbamoyl]phenoxy}acetic Acid
144. 4lb3: Crystal Structure of Human Ar Complexed with Nadp+ and {5-chloro-2- [(2-fluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic Acid
145. 4lb4: Crystal Structure of Human Ar Complexed with Nadp+ and {2-[(4-bromo-2, 3,5,6-tetrafluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic Acid
146. 4lbr: Crystal Structure of Human Ar Complexed with Nadp+ and {5-chloro-2- [(2,6-difluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic Acid
147. 4lbs: Crystal Structure of Human Ar Complexed with Nadp+ and {2-[(4-bromo-2, 6-difluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic Acid
148. 5ouk: Crystal Structure of Human AKR1B1 Complexed with Nadp+ and Compound 41
149. 5ouj: Crystal Structure of Human AKR1B1 Complexed with Nadp+ and Compound 39
150. 5ou0: Crystal Structure of Human AKR1B1 Complexed with Nadp+ and Compound 37
151. 5ha7: Human Aldose Reductase in Complex with Nadp+ and Wy14643 in Space Group P212121
152. 4nkc: Human Aldose Reductase Complexed with Schl7764 at 1.12 a
153. 4qx4: Human Aldose Reductase Complexed with a Ligand with a New Scaffold at 1.26 a
154. 4pr4: Human Aldose Reductase Complexed with Schl7802 at 1.06 a
155. 4prr: Human Aldose Reductase Complexed with Schl7815 ((3-[3-(5-nitrofuran-2- Yl)phenyl]propanoic Acid)at 1.01 a
156. 4prt: Human Aldose Reductase Complexed with Schl12221 ({2-[5-(3- Nitrophenyl)furan-2-yl]phenyl}acetic Acid) at 0.96 a
157. 4puu: Human Aldose Reductase Complexed with a Ligand with an Idd Structure (2-(2-carbamoyl-5-fluoro-phenoxy)acetic Acid) at 1.14 a
158. 4puw: Human Aldose Reductase Complexed with a Ligand with an Idd Structure (2-[5-fluoro-2-(prop-2-ynylcarbamoyl)phenoxy]acetic Acid) at 1.12 a
159. 4yu1: Human Aldose Reductase Complexed with Schl12134 (3-[5-(3-nitrophenyl)- 2-thienyl]propanoic Acid) at 1.02 a
160. 4ys1: Human Aldose Reductase Complexed with a Ligand with an Idd Structure (2) at 1.07 A.
161. 4q7b: Human Aldose Reductase Complexed with a Ligand with an Idd Structure ([2-(benzylcarbamoyl)-5-fluorophenoxy]acetic Acid) at 1.19 a
162. 4qbx: Human Aldose Reductase Complexed with a Ligand with an Idd Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic Acid) at 0.98 a
163. 4qr6: Human Aldose Reductase Complexed with a Ligand with an Idd Structure (2-[2-(1,3-benzothiazol-2-ylmethylcarbamoyl)-5-fluoro-phenoxy]acetic Acid) at 1.05 a
164. 4qxi: Crystal Structure of Human Ar Complexed with Nadp+ and Ak198
165. 4rpq: Human Aldose Reductase Complexed with a Ligand with an Idd Structure at 1.20 a (1)
166. 4xzh: Crystal Structure of Human Aldose Reductase Complexed with Nadp+ and Jf0048
167. 4xzi: Crystal Structure of Human Aldose Reductase Complexed with Nadp+ and Jf0049
168. 6tuc: Human Aldose Reductase in Complex with Alr25
169. 6tuf: Human Aldose Reductase in Complex with Alr43
170. 6txp: Human Aldose Reductase Mutant L300A in Complex with a Ligand with an Idd Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl) Benzoic Acid)
171. 6xum: Human Aldose Reductase Mutant L300/301a in Complex with a Ligand with an Idd Structure ({5-fluoro-2-[(3-nitrobenzyl) Carbamoyl]phenoxy}acetic Acid)
172. 6y03: Structure of Human Aldose Reductase Mutant L300/301a with a Citrate Molecule Bound in The Anion Binding Pocket
173. 6y1p: Human Aldose Reductase Mutant L300/301a in Complex with a Ligand with an Idd Structure (3-({[2-(carboxymethoxy)-4- Fluorobenzoyl]amino}methyl)benzoic Acid)