EC 1.1.1.42 - isocitrate:NADP ⁺ oxidoreductase (decarboxylating) (isocitrate dehydrogenase (NADP ⁺ ) )

3D structures of EC 1.1.1.42 - isocitrate dehydrogenase (NADP+) in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1ai2: Isocitrate Dehydrogenase Complexed with Isocitrate, Nadp+, and Calcium (flash-cooled)
2. 1ai3: Orbital Steering in The Catalytic Power of Enzymes: Small Structural Changes with Large Catalytic Consequences
3. 1bl5: Isocitrate Dehydrogenase from E. Coli Single Turnover Laue Structure of Rate-limited Product Complex, 10 Msec Time Resolution
4. 1cw1: Crystal Structure of Isocitrate Dehydrogenase Mutant K230M Bound to Isocitrate and Mn2+
5. 1cw4: Crystal Structure of K230M Isocitrate Dehydrogenase in Complex with Alpha-ketoglutarate
6. 1cw7: Low Temperature Structure of Wild-type Idh Complexed with Mg-isocitrate
7. 1gro: Regulatory and Catalytic Mechanisms in Escherichia Coli Isocitrate Dehydrogenase: Multiple Roles for N115
8. 1grp: Regulatory and Catalytic Mechanisms in Escherichia Coli Isocitrate Dehydrogenase: Multiple Roles for N115
9. 1hj6: Isocitrate Dehydrogenase S113E Mutant Complexed with Isopropylmalate, Nadp+ and Magnesium (flash-cooled)
10. 1hqs: Crystal Structure of Isocitrate Dehydrogenase from Bacillus Subtilis
11. 1idc: Isocitrate Dehydrogenase from E.coli (mutant K230M), Steady- State Intermediate Complex Determined by Laue Crystallography
12. 1idd: Isocitrate Dehydrogenase Y160F Mutant Apo Enzyme
13. 1ide: Isocitrate Dehydrogenase Y160F Mutant Steady-state Intermediate Complex (laue Determination)
14. 1idf: Isocitrate Dehydrogenase K230M Mutant Apo Enzyme
15. 1ika: Structure of Isocitrate Dehydrogenase with Alpha- Ketoglutarate at 2.7 Angstroms Resolution: Conformational Changes Induced by Decarboxylation of Isocitrate
16. 1iso: Isocitrate Dehydrogenase: Structure of an Engineered Nadp+-- > Nad+ Specificity-reversal Mutant
17. 1itw: Crystal Structure of The Monomeric Isocitrate Dehydrogenase in Complex with Isocitrate and Mn
18. 1j1w: Crystal Structure of The Monomeric Isocitrate Dehydrogenase in Complex with Nadp+
19. 9icd: Catalytic Mechanism of Nadp+-dependent Isocitrate Dehydrogenase: Implications from The Structures of Magnesium-isocitrate and Nadp+ Complexes
20. 8icd: Regulation of an Enzyme by Phosphorylation at The Active Site
21. 7icd: Regulation of an Enzyme by Phosphorylation at The Active Site
22. 6icd: Regulation of an Enzyme by Phosphorylation at The Active Site
23. 5icd: Regulation of an Enzyme by Phosphorylation at The Active Site
24. 4icd: Regulation of Isocitrate Dehydrogenase by Phosphorylation Involves No Long-range Conformational Change in The Free Enzyme
25. 1lwd: Crystal Structure of Nadp-dependent Isocitrate Dehydrogenase from Porcine Heart Mitochondria
26. 3mas: Crystal Structure of Heterodimeric R132H Mutant of Human Cytosolic Nadp(+)-dependent Isocitrate Dehydrogenase in Complex with Nadp and Isocitrate
27. 3mar: Crystal Structure of Homodimeric R132H Mutant of Human Cytosolic Nadp(+)-dependent Isocitrate Dehydrogenase in Complex with Nadp
28. 3map: Crystal Structure of Homodimeric R132H Mutant of Human Cytosolic Nadp(+)-dependent Isocitrate Dehydrogenase in Complex with Nadp and Isocitrate
29. 3lcb: The Crystal Structure of Isocitrate Dehydrogenase Kinase/phosphatase in Complex with Its Substrate, Isocitrate Dehydrogenase, from Escherichia Coli.
30. 1p8f: A Four Location Model to Explain The Stereospecificity of Proteins.
31. 1pb1: A Four Location Model to Explain The Stereospecificity of Proteins.
32. 1pb3: Sites of Binding and Orientation in a Four Location Model for Protein Stereospecificity.
33. 3inm: Crystal Structure of Human Cytosolic Nadp(+)-dependent Isocitrate Dehydrogenase R132H Mutant in Complex with Nadph, Alpha-ketoglutarate and Calcium(2+)
34. 3icd: Structure of a Bacterial Enzyme Regulated by Phosphorylation, Isocitrate Dehydrogenase
35. 1sjs: Access to Phosphorylation in Isocitrate Dehydrogenase May Occur by Domain Shifting
36. 1t09: Crystal Structure of Human Cytosolic Nadp(+)-dependent Isocitrate Dehydrogenase in Complex Nadp
37. 1t0l: Crystal Structure of Human Cytosolic Nadp(+)-dependent Isocitrate Dehydrogenase in Complex with Nadp, Isocitrate, and Calcium(2+)
38. 1tyo: Isocitrate Dehydrogenase from The Hyperthermophile Aeropyrum Pernix in Complex with Etheno-nadp
39. 3dms: 1.65a Crystal Structure of Isocitrate Dehydrogenase from Burkholderia Pseudomallei
40. 1v94: Crystal Structure of Isocitrate Dehydrogenase from Aeropyrum Pernix
41. 1xgv: Isocitrate Dehydrogenase from The Hyperthermophile Aeropyrum Pernix
42. 1xkd: Ternary Complex of Isocitrate Dehydrogenase from The Hyperthermophile Aeropyrum Pernix
43. 1zor: Isocitrate Dehydrogenase from The Hyperthermophile Thermotoga Maritima
44. 2b0t: Structure of Monomeric Nadp Isocitrate Dehydrogenase
45. 2qfy: Crystal Structure of Saccharomyces Cerevesiae Mitochondrial Nadp(+)-dependent Isocitrate Dehydrogenase in Complex with A-ketoglutarate
46. 2qfx: Crystal Structure of Saccharomyces Cerevesiae Mitochondrial Nadp(+)-dependent Isocitrate Dehydrogenase in Complex with Nadph, A-ketoglutarate and Ca(2+)
47. 2qfw: Crystal Structure of Saccharomyces Cerevesiae Mitochondrial Nadp(+)-dependent Isocitrate Dehydrogenase in Complex with Isocitrate
48. 2qfv: Crystal Structure of Saccharomyces Cerevesiae Mitochondrial Nadp(+)-dependent Isocitrate Dehydrogenase in Complex with Nadp(+)
49. 2d1c: Crystal Structure of Tt0538 Protein from Thermus Thermophilus Hb8
50. 2dht: Crystal Structure of Isocitrate Dehydrogenase from Sulfolobus Tokodaii Strain7
51. 6c0e: Crystal Structure of Isocitrate Dehydrogenase from Legionella Pneumophila with Bound Nadph with an Alpha-ketoglutarate Adduct
52. 6bl2: Novel Modes of Inhibition of Wild-type Idh1: Direct Covalent Modification of His315 with Cmpd15
53. 6bl1: Novel Modes of Inhibition of Wild-type Idh1: Direct Covalent Modification of His315 with Cmpd13
54. 6bl0: Novel Modes of Inhibition of Wild-type Idh1:direct Covalent Modification of His315 with Cmpd11
55. 6bkz: Novel Modes of Inhibition of Wild-type Idh1: Non-equivalent Allosteric Inhibition with Cmpd3
56. 6bky: Novel Binding Modes of Inhibition of Wild-type Idh1: Allosteric Inhibition with Cmpd2
57. 6bkx: Novel Modes of Inhibition of Wild-type Idh1: Direct Covalent Modification of His315 with Cmpd1
58. 2e0c: Crystal Structure of Isocitrate Dehydrogenase from Sulfolobus Tokodaii Strain7 at 2.0 a Resolution
59. 2e5m: Crystal Structure of Isocitrate Dehydrogenase from Sulfolobus Tokodaii Strain 7
60. 6b0z: Idh1 R132H Mutant in Complex with Idh305
61. 6ajc: Crystal Structure of Trypanosoma Cruzi Cytosolic Isocitrate Dehydrogenase in Complex with Nadp+, Isocitrate and Ca2+
62. 6ajb: Crystal Structure of Trypanosoma Brucei Glycosomal Isocitrate Dehydrogenase in Complex with Nadh, Alpha-ketoglutarate and Ca2+
63. 6aja: Crystal Structure of Trypanosoma Brucei Glycosomal Isocitrate Dehydrogenase in Complex with Nadph, Alpha-ketoglutarate and Ca2+
64. 6aj8: Crystal Structure of Trypanosoma Brucei Glycosomal Isocitrate Dehydrogenase in Complex with Nadp+, Alpha-ketoglutarate and Ca2+
65. 6aj6: Crystal Structure of Trypanosoma Brucei Glycosomal Isocitrate Dehydrogenase in Complex with Nadp+
66. 6adi: Crystal Structures of Idh2 R140Q in Complex with Ag-881
67. 6adg: Crystal Structures of Idh1 R132H in Complex with Ag-881
68. 5z16: A Novel Dimeric Isocitrate Dehydrogenase from Acinetobacter Baumannii
69. 5yzi: Crystal Structure of Mouse Cytosolic Isocitrate Dehydrogenase Complexed with Cadmium
70. 5yzh: Crystal Structure of Mouse Cytosolic Isocitrate Dehydrogenase
71. 2iv0: Thermal Stability of Isocitrate Dehydrogenase from Archaeoglobus Fulgidus Studied by Crystal Structure Analysis and Engineering of Chimers
72. 3mbc: Crystal Structure of Monomeric Isocitrate Dehydrogenase from Corynebacterium Glutamicum in Complex with Nadp
73. 6u4j: Crystal Structure of Idh1 R132H Mutant in Complex with Ft-2102
74. 3us8: Crystal Structure of an Isocitrate Dehydrogenase from Sinorhizobium Meliloti 1021
75. 6q6f: Crystal Structure of Idh1 R132H in Complex with Hms101
76. 6pay: Structure of Hsicdh1:mg(ii):ict:nadph(50%) Complex Reveals Structural Basis for Observation of Half-sites Reactivity
77. 6vei: Crystal Structure of Human Cytosolic Isocitrate Dehydrogenase (idh1) R132H Mutant in Complex with Nadph and Ag-881 (vorasidenib) Inhibitor
78. 6vfz: Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase (idh2) R140Q Mutant Homodimer in Complex with Nadph and Ag-881 (vorasidenib) Inhibitor.
79. 6vg0: Crystal Structure of Human Cytosolic Isocitrate Dehydrogenase (idh1) R132H Mutant in Complex with Nadph and Agi-15056
80. 6o2z: Crystal Structure of Idh1 R132H Mutant in Complex with Compound 32
81. 6o2y: Crystal Structure of Idh1 R132H Mutant in Complex with Compound 24
82. 4aoy: Open Ctidh. The Complex Structures of Isocitrate Dehydrogenase from Clostridium Thermocellum and Desulfotalea Psychrophila, Support a New Active Site Locking Mechanism
83. 4aou: Ctidh Bound to Nadp. The Complex Structures of Isocitrate Dehydrogenase from Clostridium Thermocellum and Desulfotalea Psychrophila, Support a New Active Site Locking Mechanism
84. 4aov: Dpidh-nadp. The Complex Structures of Isocitrate Dehydrogenase from Clostridium Thermocellum and Desulfotalea Psychrophila, Support a New Active Site Locking Mechanism
85. 6io0: Human Idh1 R132C Mutant Complexed with Compound A.
86. 4aj3: 3d Structure of E. Coli Isocitrate Dehydrogenase in Complex with Isocitrate, Calcium(ii) and Nadp - The Pseudo-michaelis Complex
87. 4aja: 3d Structure of E. Coli Isocitrate Dehydrogenase in Complex with Isocitrate, Calcium(ii) and Thionadp
88. 4ajb: 3d Structure of E. Coli Isocitrate Dehydrogenase K100M Mutant in Complex with Isocitrate, Magnesium(ii) and Thionadp
89. 4ajc: 3d Structure of E. Coli Isocitrate Dehydrogenase K100M Mutant in Complex with Alpha-ketoglutarate, Calcium(ii) and Adenine Nucleotide Phosphate
90. 4ajr: 3d Structure of E. Coli Isocitrate Dehydrogenase K100M Mutant in Complex with Alpha-ketoglutarate, Magnesium(ii) and Nadph - The Product Complex
91. 4hcx: Structure of Icdh-1 from M.tuberculosis Complexed with Nadph & Mn2+
92. 4ja8: Complex of Mitochondrial Isocitrate Dehydrogenase R140Q Mutant with Agi-6780 Inhibitor
93. 4i3k: Crystal Structure of a Metabolic Reductase with 1-hydroxy-6-(4- Hydroxybenzyl)-4-methylpyridin-2(1h)-one
94. 4i3l: Crystal Structure of a Metabolic Reductase with 6-benzyl-1-hydroxy-4- Methylpyridin-2(1h)-one
95. 4kzo: Crystal Structure Analysis of Human Idh1 Mutants in Complex with Nadp+ and Ca2+/alpha-ketoglutarate
96. 4l03: Crystal Structure Analysis of Human Idh1 Mutants in Complex with Nadp+ and Ca2+/alpha-ketoglutarate
97. 4l06: Crystal Structure Analysis of Human Idh1 Mutants in Complex with Nadp+ and Ca2+/alpha-ketoglutarate
98. 4l04: Crystal Structure Analysis of Human Idh1 Mutants in Complex with Nadp+ and Ca2+/alpha-ketoglutarate
99. 4bnp: 3d Structure of E. Coli Isocitrate Dehydrogenase K100M Mutant in Complex with Isocitrate and Magnesium(ii)
100. 5yfn: Human Isocitrate Dehydrogenase 1 Bound with Isocitrate
101. 5yfm: Human Isocitrate Dehydrogenase 1 Bound with Nadp
102. 4p69: Acek (D477A) Icdh Complex
103. 4umx: Idh1 R132H in Complex with Cpd 1
104. 4umy: Idh1 R132H in Complex with Cpd 1
105. 5tqh: Idh1 R132H Mutant in Complex with Idh889
106. 5svo: Structure of Idh2 Mutant R140Q
107. 5svn: Structure of Idh2 Mutant R172K
108. 5svf: Idh1 R132H in Complex with Idh125
109. 5sun: Idh1 R132H in Complex with Idh146
110. 5m2e: Apo Structure of Pseudomonas Aeruginosa Isocitrate Dehydrogenase, Icd.
111. 5lge: Crystal Structure of Human Idh1 Mutant (R132H) in Complex with Nadp+ and an Inhibitor Related to Bay 1436032
112. 5l58: Crystal Structure of Iso-citrate Dehydrogenase 1 [idh1 (R132H)] in Complex with a Novel Inhibitor (compound 2)
113. 5l57: Crystal Structure of Iso-citrate Dehydrogenase R132H in Complex with a Novel Inhibitor (compound 13a)
114. 5kvu: Crystal Structure of Isocitrate Dehydrogenase-2 in Complex with Nadp(+) from Mycobacterium Tuberculosis
115. 5k11: Cryo-em Structure of Isocitrate Dehydrogenase (idh1) in Inhibitor- Bound State
116. 5k10: Cryo-em Structure of Isocitrate Dehydrogenase (idh1)
117. 5i96: Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase (idh2) R140Q Mutant Homodimer in Complex with Ag-221 (enasidenib) Inhibitor.
118. 5i95: Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Homodimer Bound to Nadph and Alpha-ketoglutaric Acid
119. 5h3f: Crystal Structure of Mouse Isocitrate Dehydrogenases 2 Complexed with Isocitrate
120. 5h3e: Crystal Structure of Mouse Isocitrate Dehydrogenases 2 K256Q Mutant Complexed with Isocitrate
121. 5de1: Crystal Structure of Human Idh1 in Complex with GSK321A
122. 4zda: Crystal Structure of Isocitrate Dehydrogenase in Complex with Isocitrate and Mn from M. Smegmatis
123. 4xrx: Crystal Structure of a Metabolic Reductase with (e)-5-((1-methyl-5- Oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1h)-one
124. 4xs3: Crystal Structure of a Metabolic Reductase with (e)-1-benzyl-5-((1- Methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1h)-one
125. 6uj7: Crystal Structure of Hla-b*07:02 with R140Q Mutant Idh2 Peptide
126. 6uj8: Crystal Structure of Hla-b*07:02 with Wild-type Idh2 Peptide
127. 6uj9: Crystal Structure of Hla-b*07:02 with R140Q Mutant Idh2 Peptide in Complex with Fab