EC 2.7.11.21 - ATP:protein phosphotransferase (spindle- pole- dependent) (polo kinase)

3D structures of EC 2.7.11.21 - polo kinase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 3kb7: Crystal Structure of Polo-like Kinase 1 in Complex with a Pyrazoloquinazoline Inhibitor
2. 3hik: Structure of Human Plk1-pbd in Complex with Plhspt
3. 3hih: Structure of Human Plk1-pbd with Glycerol and Sulfate in The Phophopeptide Binding Site
4. 3fvh: Polo-like Kinase 1 Polo Box Domain in Complex with Ac- Lhspta-nh2 Peptide
5. 3fc2: Plk1 in Complex with Bi6727
6. 3dbf: Crystal Structure of an Activated (thr->asp) Polo-like Kinase 1 (plk1) Catalytic Domain in Complex with Compound 562
7. 3dbe: Crystal Structure of an Activated (thr->asp) Polo-like Kinase 1 (plk1) Catalytic Domain in Complex with Compound 557
8. 3dbd: Crystal Structure of an Activated (thr->asp) Polo-like Kinase 1 (plk1) Catalytic Domain in Complex with Compound 094
9. 3dbc: Crystal Structure of an Activated (thr->asp) Polo-like Kinase 1 (plk1) Catalytic Domain in Complex with Compound 257
10. 3db8: Crystal Structure of an Activated (thr->asp) Polo-like Kinase 1 (plk1) Catalytic Domain in Complex with Compound 041
11. 3db6: Crystal Structure of an Activated (thr->asp) Polo-like Kinase 1 (plk1) Catalytic Domain in Complex with Compound 902
12. 3d5x: Crystal Structure of an Activated (thr->asp) Polo-like Kinase 1 (plk1) Catalytic Domain in Complex with Wortmannin.
13. 3d5w: Crystal Structure of a Phosphorylated Polo-like Kinase 1 (plk1) Catalytic Domain in Complex with Adp.
14. 3d5v: Crystal Structure of an Activated (thr->asp) Polo-like Kinase 1 (plk1) Catalytic Domain.
15. 3d5u: Crystal Structure of a Wildtype Polo-like Kinase 1 (plk1) Catalytic Domain.
16. 3cok: Crystal Structure of Plk4 Kinase
17. 3c5l: Polo-like Kinase 1 Polo Box Domain in Complex with Pphspt Peptide
18. 3bzi: Molecular and Structural Basis of Polo-like Kinase 1 Substrate Recognition: Implications in Centrosomal Localization
19. 2v5q: Crystal Structure of Wild-type Plk-1 Kinase Domain in Complex with a Selective Darpin
20. 2rku: Structure of Plk1 in Complex with Bi2536
21. 2owb: Structure of The Catalytic Domain of Human Polo-like Kinase 1
22. 2ou7: Structure of The Catalytic Domain of Human Polo-like Kinase 1
23. 2ojx: Molecular and Structural Basis of Polo-like Kinase 1 Substrate Recognition: Implications in Centrosomal Localization
24. 2ogq: Molecular and Structural Basis of Plk1 Substrate Recognition: Implications in Centrosomal Localization
25. 6ax4: Plk-1 Polo-box Domain in Complex with Histidine N(tau)-cyclized Macrocycle 5b.
26. 6mf6: Crystal Structure of Budding Yeast Cdc5 Polo-box Domain in Complex with The Dbf4 Polo-interacting Region.
27. 2yac: Crystal Structure of Polo-like Kinase 1 in Complex with Nms-p937
28. 3p2w: Unliganded Form of Polo-like Kinase I Polo-box Domain
29. 3p2z: Polo-like Kinase I Polo-box Domain in Complex with Plhspta Phosphopeptide from Pbip1
30. 3p34: Polo-like Kinase I Polo-box Domain in Complex with Mqsptpl Phosphopeptide
31. 3p35: Polo-like Kinase I Polo-box Domain in Complex with Mqspspl Phosphopeptide
32. 3p36: Polo-like Kinase I Polo-box Domain in Complex with Dpplhspta Phosphopeptide from Pbip1
33. 3p37: Polo-like Kinase I Polo-box Domain in Complex with Fdpplhspta Phosphopeptide from Pbip1
34. 3q1i: Polo-like Kinase I Polo-box Domain in Complex with Fmpppmspsm Phosphopeptide from Tcerg1
35. 6w3j: Crystal Structure of The FAM46C/PLK4/CEP192 Complex
36. 6w3i: Crystal Structure of a FAM46C Mutant in Complex with Plk4
37. 6w38: Crystal Structure of The FAM46C/PLK4 Complex
38. 3rq7: Polo-like Kinase 1 Polo Box Domain in Complex with a C6H5(CH2)8- Derivatized Peptide Inhibitor
39. 3thb: Structure of Plk1 Kinase Domain in Complex with a Benzolactam-derived Inhibitor
40. 4a4l: Crystal Structure of Polo-like Kinase 1 in Complex with a 5-(2-amino-pyrimidin-4-yl)-1h-pyrrole Inhibitor
41. 4a4o: Crystal Structure of Polo-like Kinase 1 in Complex with a 2- (2-amino-pyrimidin-4-yl)-1,5,6,7-tetrahydro-pyrrolopyridin- 4-one Inhibitor
42. 4dfw: Oxime-based post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (plk1) Polo-box Domain Binding Peptides
43. 6n46: Crystal Structure of The Cryptic Polo Box Domain of a Human Activated Plk4
44. 6n45: Crystal Structure of The Cryptic Polo Box Domain of Human Activated Plk4 Variant 1
45. 4e67: The Structure of The Polo-box Domain (pbd) of Polo-like Kinase 1 (plk1) in Complex with Hydrocinnamoyl-derivatized Plhspta Peptide
46. 4e9c: The Structure of The Polo-box Domain (pbd) of Polo-like Kinase 1 (plk1) in Complex with Ldpplhspta Phosphopeptide
47. 4e9d: The Structure of The Polo-box Domain (pbd) of Polo-like Kinase 1 (plk1) in Complex with 3-(1-benzothiophen-2-yl)propanoyl-derivatized Dpplhspta Peptide
48. 4g7n: The Structure of The Plk4 Cryptic Polo Box Reveals Two Tandem Polo Boxes Required for Centriole Duplication
49. 4h5x: Human Plk1-pbd with a Glycerol Bound at The Phophopeptide Binding Site
50. 4h71: Human Plk1-pbd in Complex with Poloxime ((e)-4-(hydroxyimino)-2- Isopropyl-5-methylcyclohexa-2,5-dienone)
51. 4hco: Human Plk1-pbd in Complex with Thymoquinone at The Phophopeptide Binding Site
52. 6mf4: Crystal Structure of The Polo-box Domain of Cdc5 from Budding Yeast.
53. 6gy2: Crystal Structure of Human Plk1-pbd in Complex with Wssslatpptlssptvli Phosphopeptide from Brca2
54. 4hab: Crystal Structure of Plk1 Polo-box Domain in Complex with Pl-49
55. 4hy2: Crystal Structure of Plk1 Polo-box Domain in Complex with Pl-42
56. 4j52: Crystal Structure of Plk1 in Complex with a Pyrimidodiazepinone Inhibitor
57. 4j53: Crystal Structure of Plk1 in Complex with Tak-960
58. 4j7b: Crystal Structure of Polo-like Kinase 1
59. 4b6l: Discovery of Oral Polo-like Kinase (plk) Inhibitors with Enhanced Selectivity Profile Using Residue Targeted Drug Design
60. 6mf5: Crystal Structure of Budding Yeast Cdc5 Polo-box Domain in Complex with Spc72 Phosphopeptide.
61. 4i5m: Selective & Brain-permeable Polo-like Kinase-2 (plk-2) Inhibitors That Reduce -synuclein Phosphorylation in Rat Brain
62. 4i5p: Selective & Brain-permeable Polo-like Kinase-2 (plk-2) Inhibitors That Reduce -synuclein Phosphorylation in Rat Brain
63. 4i6b: Selective & Brain-permeable Polo-like Kinase-2 (plk-2) Inhibitors That Reduce -synuclein Phosphorylation in Rat Brain
64. 4i6f: Selective & Brain-permeable Polo-like Kinase-2 (plk-2) Inhibitors That Reduce -synuclein Phosphorylation in Rat Brain
65. 4i6h: Selective & Brain-permeable Polo-like Kinase-2 (plk-2) Inhibitors That Reduce Alpha-synuclein Phosphorylation in Rat Brain
66. 4jxf: Crystal Structure of Plk4 Kinase with an Inhibitor: 400631 ((1r,2s)-2- {3-[(e)-2-{4-[(dimethylamino)methyl]phenyl}ethenyl]-2h-indazol-6-yl}- 5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'h)-one)
67. 4lkl: Crystal Structure of Plk1 Polo-box Domain in Complex with Pl-55
68. 4lkm: Crystal Structure of Plk1 Polo-box Domain in Complex with Pl-74
69. 4n7v: Crystal Structure of Human Plk4 Cryptic Polo Box (cpb) in Complex with a Cep152 N-terminal Fragment
70. 4n7z: Crystal Structure of Human Plk4 Cryptic Polo Box (cpb) in Complex with a Cep192 N-terminal Fragment
71. 4n9j: Crystal Structure of The Cryptic Polo Box Domain of Human Plk4
72. 4nk7: Crystal Structure of The D. Melanogaster Plk4 Cryptic Polo Box (cpb)
73. 4o9w: Crystal Structure of Polo-like Kinase(plk1)pbd in Complex with Phospho Peptide
74. 5x3s: Crystal Structure of Mouse Plk1-pbd in Complex with Phosphopeptide from Hef1 (799-809)
75. 4rcp: Crystal Structure of Plk1 Polo-box Domain in Complex with Pl-2
76. 4o6w: Peptide-based Inhibitors of Plk1 Polo-box Domain
77. 4rs6: Crystal Structure of The C Domain of Polo like Kinase II in Homo Sapiens
78. 4whh: A New Class of Peptidomimetics Targeting The Polo-box Domain of Polo- like Kinase 1
79. 4whk: A New Class of Peptidomimetics Targeting The Polo-box Domain of Polo- like Kinase 1
80. 4whl: A New Class of Peptidomimetics Targeting The Polo-box Domain of Polo- like Kinase 1
81. 5ta8: Crystal Structure of Plk1 in Complex with a Novel 5,6- Dihydroimidazolo[1,5-f]pteridine Inhibitor
82. 5ta6: Crystal Structure of Plk1 in Complex with a Novel 5,6- Dihydroimidazolo[1,5-f]pteridine Inhibitor.
83. 5nn2: The Structure of The Polo-box Domain (pbd) of Plk1 in Complex with Z228588490
84. 5nn1: The Structure of The Polo-box Domain (pbd) of Polo-like Kinase 1 (plk1)
85. 5nmm: The Structure of The Polo-box Domain (pbd) of Plk1 in Complex with Alpha-bromo-3-iodotoluene.
86. 5nje: The Structure of The Polo-box Domain (pbd) of Polo-like Kinase 1 (plk1) in Complex with Alpha-bromo-3-iodotoluene.
87. 5nfu: The Structure of The Polo-box Domain (pbd) of Polo-like Kinase 1 (plk1) in Complex with Lhspta Peptide.
88. 5nei: The Structure of The Polo-box Domain (pbd) of Polo-like Kinase 1 (plk1) in Complex with Jes107
89. 5lhz: Pb3 Domain of Human Plk4 in Complex with Coiled-coil Domain of Stil
90. 5lhy: Pb3 Domain of Human Plk4 (apo)
91. 5lhx: Pb3 Domain of Drosophila Melanogaster Plk4 (sak)
92. 5j19: Phospho-pon Binding-induced Plk1 Dimerization
93. 5dnj: Mouse Polo-box Domain and Peptide Analog 702
94. 5dmv: Polo-box Domain of Mouse Polo-like Kinase 1 Complexed with Emi2 (146- 177)
95. 5dms: Mouse Polo-box Domain and Emi2 (169-177)
96. 4o56: Structure of Plk1 in Complex with Peptide
97. 4yyp: Crystal Structure of Human Plk4-pb3 in Complex with Stil-cc
98. 4yur: Crystal Structure of Plk4 Kinase Domain Bound to Centrinone
99. 4xb0: Structure of The Plk2 Polo-box Domain
100. 2n19: Stil Binding to The Polo-box Domain 3 of Plk4 Regulates Centriole Duplication
101. 4x9r: Plk-1 Polo-box Domain in Complex with Bioactive Imidazolium-containing Phosphopeptide Macrocycle 3b
102. 4x9v: Plk-1 Polo-box Domain in Complex with Bioactive Imidazolium-containing Phosphopeptide Macrocycle 3c
103. 4x9w: Plk-1 Polo-box Domain in Complex with Bioactive Imidazolium-containing Phosphopeptide Macrocycle 4c