Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy   |   
enzyme (lysozyme)

 
Enzymes
  Enzyme classes:
  EC 1: Oxidoreductases
  EC 2: Transferases
    EC 2.1
    EC 2.2
    EC 2.3
    EC 2.4
    EC 2.5
    EC 2.6
    EC 2.7
      EC 2.7.1
      EC 2.7.2
      EC 2.7.3
      EC 2.7.4
      EC 2.7.5
      EC 2.7.6
      EC 2.7.7
      EC 2.7.8
      EC 2.7.9
      EC 2.7.10
      EC 2.7.11
        EC 2.7.11.1
        EC 2.7.11.2
        EC 2.7.11.3
        EC 2.7.11.4
        EC 2.7.11.6
        EC 2.7.11.7
        EC 2.7.11.8
        EC 2.7.11.9
        EC 2.7.11.10
        EC 2.7.11.11
        EC 2.7.11.12
        EC 2.7.11.13
        EC 2.7.11.14
        EC 2.7.11.15
        EC 2.7.11.16
        EC 2.7.11.17
        EC 2.7.11.18
        EC 2.7.11.19
        EC 2.7.11.20
        EC 2.7.11.21
        EC 2.7.11.22
        EC 2.7.11.23
        EC 2.7.11.24
        EC 2.7.11.25
        EC 2.7.11.26
        EC 2.7.11.27
        EC 2.7.11.28
        EC 2.7.11.29
        EC 2.7.11.30
        EC 2.7.11.31
      EC 2.7.12
      EC 2.7.13
      EC 2.7.14
    EC 2.8
    EC 2.9
  EC 3: Hydrolases
  EC 4: Lyases
  EC 5: Isomerases
  EC 6: Ligases
  General information:
  Catalytic mechanism
  Enzyme kinetics
  Inhibitors
  Enzymes in industry

EC 2.7.11.24 - ATP:protein phosphotransferase (MAPKK- activated) (mitogen- activated protein kinase)



3D structures of EC 2.7.11.24 - mitogen-activated protein kinase in Protein Data Bank

updated: 3 March 2021, 5:15

In total: 581 PDB structures of EC 2.7.11.24 - mitogen-activated protein kinase:
  1. 6y4v: Crystal Structure of P38 in Complex with Sr68
  2. 1lew: Crystal Structure of Map Kinase P38 Complexed to The Docking Site on Its Nuclear Substrate MEF2A
  3. 3ocg: P38 Alpha Kinase Complexed with a 5-amino-pyrazole Based Inhibitor
  4. 3oc1: Conformational Plasticity of P38 Map Kinase Dfg Motif Mutants in Response to Inhibitor Binding
  5. 3obj: Conformational Plasticity of P38 Map Kinase Dfg Mutants in Response to Inhibitor Binding
  6. 3obg: Conformational Plasticity of P38 Map Kinase Dfg Mutants in Response to Inhibitor Binding
  7. 3o8u: Conformational Plasticity of P38 Map Kinase Dfg Motif Mutants in Response to Inhibitor Binding
  8. 3o8t: Conformational Plasticity of P38 Map Kinase Dfg-motif Mutants in Response to Inhibitor Binding
  9. 3o8p: Conformational Plasticity of P38 Map Kinase Dfg Motif Mutants in Response to Inhibitor Binding
  10. 3nww: P38 Alpha Kinase Complexed with a 2-aminothiazol-5-yl-pyrimidine Based Inhibitor
  11. 3npc: Crystal Structure of Jnk2 Complexed with Birb796
  12. 3nnx: Crystal Structure of Phosphorylated P38 Alpha in Complex with Dp802
  13. 3nnw: Crystal Structure of P38 Alpha in Complex with Dp802
  14. 3nnv: Crystal Structure of P38 Alpha in Complex with Dp437
  15. 3nnu: Crystal Structure of P38 Alpha in Complex with Dp1376
  16. 3new: P38-alpha Complexed with Compound 10
  17. 3mvm: P38 Alpha Map Kinase Complexed with Pyrrolotriazine Inhibitor 7v
  18. 3mvl: P38 Alpha Map Kinase Complexed with Pyrrolotriazine Inhibitor 7k
  19. 3mpt: Crystal Structure of P38 Kinase in Complex with a Pyrrole-2- Carboxamide Inhibitor
  20. 3mpa: Conformational Plasticity of P38 Map Kinase Dfg Motif Mutants in Response to Inhibitor Binding
  21. 3mh3: Mutagenesis of P38 Map Kinase Establishes Key Roles of Phe169 in Function and Structural Dynamics and Reveals a Novel Dfg-out State
  22. 3mh2: Mutagenesis of P38 Map Kinase Establishes Key Roles of Phe169 in Function and Structural Dynamics and Reveals a Novel Dfg-out State
  23. 3mh1: Mutagenesis of P38 Map Kinase Establishes Key Roles of Phe169 in Function and Structural Dynamics and Reveals a Novel Dfg-out State
  24. 3mh0: Mutagenesis of P38 Map Kinase Eshtablishes Key Roles of Phe169 in Function and Structural Dynamics and Reveals a Novel Dfg-out State
  25. 3mgy: Mutagenesis of P38 Map Kinase Eshtablishes Key Roles of Phe169 in Function and Structural Dynamics and Reveals a Novel Dfg-out State
  26. 3lhj: Crystal Structure of P38A Mitogen-activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor.
  27. 3l8x: P38 Alpha Kinase Complexed with a Pyrazolo-pyrimidine Based Inhibitor
  28. 3l8s: Human P38 Map Kinase in Complex with Cp-547632
  29. 3kvx: Jnk3 Bound to Aminopyrimidine Inhibitor, Sr-3562
  30. 3kq7: Structure of Human P38ALPHA with N-[4-methyl-3-(6-{[2-(1- Methylpyrrolidin-2-yl)ethyl]amino}pyridine-3-amido)phenyl]- 2-(morpholin-4-yl)pyridine-4-carboxamide
  31. 3kf7: Crystal Structure of Human P38ALPHA Complexed with a Triazolopyrimidine Compound
  32. 3k3j: P38ALPHA Bound to Novel Dfg-out Compound Pf-00416121
  33. 3k3i: P38ALPHA Bound to Novel Dgf-out Compound Pf-00215955
  34. 3iw8: Structure of Inactive Human P38 Map Kinase in Complex with a Thiazole-urea
  35. 3iw7: Human P38 Map Kinase in Complex with an Imidazo-pyridine
  36. 3iw6: Human P38 Map Kinase in Complex with a Benzylpiperazin- Pyrrol
  37. 3iw5: Human P38 Map Kinase in Complex with an Indole Derivative
  38. 3itz: Crystal Structure of P38A Mitogen-activated Protein Kinase in Complex with a Pyrazolopyridazine Inhibitor
  39. 3iph: Crystal Structure of P38 in Complex with a Biphenylamide Inhibitor
  40. 3i60: Crystal Structure of Erk2 Bound to (s)-4-(2-(2- Chlorophenylamino)-5-methylpyrimidin-4-yl)-n-(2-hydroxy-1- Phenylethyl)-1h-pyrrole-2-carboxamide
  41. 3i5z: Crystal Structure of Erk2 Bound to (s)-n-(2-hydroxy-1- Phenylethyl)-4-(5-methyl-2-(phenylamino)pyrimidin-4-yl)-1h- Pyrrole-2-carboxamide
  42. 3hvc: Crystal Structure of Human P38ALPHA Map Kinase
  43. 3hv7: Human P38 Map Kinase in Complex with Rl38
  44. 3hv6: Human P38 Map Kinase in Complex with Rl39
  45. 3hv5: Human P38 Map Kinase in Complex with Rl24
  46. 3hv4: Human P38 Map Kinase in Complex with Rl51
  47. 3hv3: Human P38 Map Kinase in Complex with Rl49
  48. 3huc: Human P38 Map Kinase in Complex with Rl40
  49. 3hub: Human P38 Map Kinase in Complex with Scios-469
  50. 3hrb: P38 Kinase Crystal Structure in Complex with Small Molecule Inhibitor
  51. 3hp5: Crystal Structure of Human P38ALPHA Complexed with a Pyrimidopyridazinone Compound
  52. 3hp2: Crystal Structure of Human P38ALPHA Complexed with a Pyridinone Compound
  53. 3hll: Crystal Structure of Human P38ALPHA Complexed with Ph-797804
  54. 3hl7: Crystal Structure of Human P38ALPHA Complexed with Sd-0006
  55. 3heg: P38 in Complex with Sorafenib
  56. 3hec: P38 in Complex with Imatinib
  57. 3ha8: The Complex Structure of The Map Kinase P38/compound 14b
  58. 3gp0: Crystal Structure of Human Mitogen Activated Protein Kinase 11 (p38 Beta) in Complex with Nilotinib
  59. 3gi3: Crystal Structure of a N-phenyl-n'-naphthylurea Analog in Complex with P38 Map Kinase
  60. 3gfe: Crystal Structure of P38A Mitogen-activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor
  61. 3gcv: Human P38 Map Kinase in Complex with Rl62
  62. 3gcu: Human P38 Map Kinase in Complex with Rl48
  63. 3gcs: Human P38 Map Kinase in Complex with Sorafenib
  64. 3gcq: Human P38 Map Kinase in Complex with Rl45
  65. 3gcp: Human P38 Map Kinase in Complex with Sb203580
  66. 3gc9: The Structure of P38BETA C119S, C162S in Complex with a Dihydroquinazolinone Inhibitor
  67. 3gc8: The Structure of P38BETA C162S in Complex with a Dihydroquinazolinone
  68. 3gc7: The Structure of P38ALPHA in Complex with a Dihydroquinazolinone
  69. 3g9n: Jnk3 Bound to (z)-1-((6-fluoro-4h-benzo[d][1,3]dioxin-8-yl) Methyl)-3-(hydroxyimino)-4-phenylindolin-2-one
  70. 3g9l: Jnk3 Bound to (z)-1-((6-fluoro-4h-benzo[d][1,3]dioxin-8-yl) Methyl)-3-(hydroxyimino)-4-styrylindolin-2-one
  71. 3g90: Jnk-3 Bound to (z)-5-fluoro-1-((6-fluoro-4h-benzo[d][1, 3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one
  72. 3fv8: Jnk3 Bound to Piperazine Amide Inhibitor, Sr2774.
  73. 3fsk: P38 Kinase Crystal Structure in Complex with Ro6257
  74. 3fsf: P38 Kinase Crystal Structure in Complex with 3-(2,6- Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]- 1-methyl-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one
  75. 3fmn: P38 Kinase Crystal Structure in Complex with Ro2530
  76. 3fmm: P38 Kinase Crystal Structure in Complex with Ro6226
  77. 3fml: P38 Kinase Crystal Structure in Complex with Ro6224
  78. 3fmk: P38 Kinase Crystal Structure in Complex with 6-(2,4- Difluoro-phenoxy)-8-methyl-2-((s)-1-methyl-2-tetrazol-2-yl- Ethylamino)-8h-pyrido[2,3-d]pyrimidin-7-one
  79. 3fmj: P38 Kinase Crystal Structure in Complex with 4-(5-methyl-3- Phenyl-isoxazol-4-yl)-pyrimidin-2-ylamine
  80. 3fmh: P38 Kinase Crystal Structure in Complex with 6-(2,4- Difluoro-phenoxy)-8-methyl-2-((r)-1-methyl-2-tetrazol-2-yl- Ethylamino)-8h-pyrido[2,3-d]pyrimidin-7-one
  81. 3flz: P38 Kinase Crystal Structure in Complex with 8-methyl-6- Phenoxy-2-(tetrahydro-pyran-4-ylamino)-8h-pyrido[2,3- D]pyrimidin-7-one
  82. 3fly: P38 Kinase Crystal Structure in Complex with 6-(2,4- Difluoro-phenoxy)-2-isopropylamino-8-methyl-8h-pyrido[2,3- D]pyrimidin-7-one
  83. 3flw: P38 Kinase Crystal Structure in Complex with Pamapimod
  84. 3fls: P38 Kinase Crystal Structure in Complex with 6-(2,4- Difluoro-phenoxy)-2-((r)-2-methanesulfonyl-1-methyl- Ethylamino)-8-methyl-8h-pyrido[2,3-d]pyrimidin-7-one
  85. 3flq: P38 Kinase Crystal Structure in Complex with 6-(2,4- Difluoro-phenoxy)-2-((s)-2-methanesulfonyl-1-methyl- Ethylamino)-8-methyl-8h-pyrido[2,3-d]pyrimidin
  86. 3fln: P38 Kinase Crystal Structure in Complex with R1487
  87. 3fl4: P38 Kinase Crystal Structure in Complex with Ro5634
  88. 3fko: P38 Kinase Crystal Structure in Complex with Ro3668
  89. 3fkn: P38 Kinase Crystal Structure in Complex with Ro7125
  90. 3fkl: P38 Kinase Crystal Structure in Complex with Ro9552
  91. 3fi4: P38 Kinase Crystal Structure in Complex with Ro4499
  92. 3fi3: Crystal Structure of Jnk3 with Indazole Inhibitor, Sr-3737
  93. 3fi2: Crystal Structure of Jnk3 with Amino-pyrazole Inhibitor, Sr- 3451
  94. 3fc1: Crystal Structure of P38 Kinase Bound to Pyrimido- Pyridazinone Inhibitor
  95. 6y4x: Crystal Structure of P38 in Complex with Sr72
  96. 3elj: Jnk1 Complexed with a Bis-anilino-pyrrolopyrimidine Inhibitor.
  97. 3e93: Crystal Structure of P38 Kinase in Complex with a Biaryl Amide Inhibitor
  98. 3e92: Crystal Structure of P38 Kinase in Complex with a Biaryl Amide Inhibitor
  99. 3e7o: Crystal Structure of Jnk2
  100. 3dt1: P38 Complexed with a Quinazoline Inhibitor
  101. 3ds6: P38 Complex with a Phthalazine Inhibitor
  102. 3da6: Crystal Structure of Human Jnk3 Complexed with N-(3-methyl- 4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy) Naphthalen-1-yl)-1h-benzo[d]imidazol-2-amine
  103. 3d83: Crystal Structure of P38 Kinase in Complex with a Biphenyl Amide Inhibitor
  104. 3d7z: Crystal Structure of P38 Kinase in Complex with a Biphenyl Amide Inhibitor
  105. 3ctq: Structure of Map Kinase P38 in Complex with a 1-o-tolyl-1,2, 3-triazole-4-carboxamide
  106. 3coi: Crystal Structure of P38DELTA Kinase
  107. 3cgo: Irak-4 Inhibitors (part Ii)- a Structure Based Assessment of Imidazo[1,2 A]pyridine Binding
  108. 3cgf: Irak-4 Inhibitors (part Ii)- a Structure Based Assessment of Imidazo[1,2 A]pyridine Binding
  109. 3c9w: Crystal Structure of Erk-2 with Hypothemycin Covalently Bound
  110. 3c5u: P38 Alpha Map Kinase Complexed with a Benzothiazole Based Inhibitor
  111. 3bx5: P38 Alpha Map Kinase Complexed with Bms-640994
  112. 3bv3: Morpholino Pyrrolotriazine P38 Alpha Map Kinase Inhibitor Compound 2
  113. 3bv2: Morpholino Pyrrolotriazine P38 Alpha Map Kinase Inhibitor Compound 30
  114. 2zoq: Structural Dissection of Human Mitogen-activated Kinase Erk1
  115. 2zdu: Crystal Structure of Human Jnk3 Complexed with an Isoquinolone Inhibitor
  116. 2zdt: Crystal Structure of Human Jnk3 Complexed with an Isoquinolone Inhibitor
  117. 2zb1: Crystal Structure of P38 in Complex with Biphenyl Amide Inhibitor
  118. 2zb0: Crystal Structure of P38 in Complex with Biphenyl Amide Inhibitor
  119. 2zaz: Crystal Structure of P38 in Complex with 4-anilino Quinoline Inhibitor
  120. 2z7l: Unphosphorylated Mitogen Activated Protein Kinase Erk2 in Complex with (4-{[5-carbamoyl-4-(3-methylanilino)pyrimidin 2-yl]amino}phenyl)acetic Acid
  121. 2waj: Crystal Structure of Human Jnk3 Complexed with a 1-aryl-3,4- Dihydroisoquinoline Inhibitor
  122. 7cml: The Crystal Structure of Human Jnk2 from Wuxi Biortus.
  123. 7aqb: Crystal Structure of Human Mitogen Activated Protein Kinase 6 (mapk6)
  124. 6zwr: P38A Bound with Sr92
  125. 6zwp: P38A Bound with Sr348
  126. 6zr5: Crystal Structure of Jnk1 in Complex with Atf2(19-58)
  127. 6zqs: Crystal Structure of Double-phosphorylated P38ALPHA with Atf2(83-102)
  128. 2rg6: Phenylalanine Pyrrolotriazine P38 Alpha Map Kinase Inhibitor Compound 11j
  129. 2rg5: Phenylalanine Pyrrolotriazine P38 Alpha Map Kinase Inhibitor Compound 11b
  130. 2r9s: C-jun N-terminal Kinase 3 with 3,5-disubstituted Quinoline Inhibitor
  131. 2qd9: P38 Alpha Map Kinase Inhibitor Based on Heterobicyclic Scaffolds
  132. 2q8y: Structural Insight into The Enzymatic Mechanism of The Phophothreonine Lyase
  133. 2puu: Crystal Structure of P38 Complex with 1-(5-tert-butyl-2-p- Tolyl-2h-pyrazol-3-yl)-3-[4-(6-morpholin-4-ylmethyl- Pyridin-3-yl)naphthalen-1-yl]urea
  134. 2p33: Synthesis and Sar of Aminopyrimidines as Novel C-jun N- Terminal Kinase (jnk) Inhibitors
  135. 2oza: Structure of P38ALPHA Complex
  136. 2onl: Crystal Structure of The P38A-MAPKAP Kinase 2 Heterodimer
  137. 2okr: Crystal Structure of The P38A-MAPKAP Kinase 2 Heterodimer
  138. 2ok1: Crystal Structure of Jnk3 Bound to N-benzyl-4-(4-(3- Chlorophenyl)-1h-pyrazol-3-yl)-1h-pyrrole-2-carboxamide
  139. 6yll: Biochemical, Cellular and Structural Characterization of Novel Erk3 Inhibitors
  140. 6ylc: Biochemical, Cellular and Structural Characterization of Novel Erk3 Inhibitors
  141. 2ojj: Crystal Structure of Erk2 in Complex with (s)-n-(1-(3- Chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3- Chlorophenyl)-1h-pyrazol-3-yl)-1h-pyrrole-2-carboxamide
  142. 2oji: Crystal Structure of Erk2 in Complex with N-benzyl-4-(4-(3- Chlorophenyl)-1h-pyrazol-3-yl)-1h-pyrrole-2-carboxamide
  143. 2ojg: Crystal Structure of Erk2 in Complex with N,n-dimethyl-4-(4- Phenyl-1h-pyrazol-3-yl)-1h-pyrrole-2-carboxamide
  144. 6yky: Biochemical, Cellular and Structural Characterization of Novel Erk3 Inhibitors
  145. 6yjc: Crystal Structure of P38ALPHA in Complex with Sr154
  146. 2o2u: Crystal Structure of Human Jnk3 Complexed with N-(3-cyano-4, 5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
  147. 2o0u: Crystal Structure of Human Jnk3 Complexed with N-{3-cyano-6- [3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3- C]pyridin-2-yl}-1-naphthalenecarboxamide
  148. 6anl: Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based P38 Map Kinase Inhibitors
  149. 2npq: A Novel Lipid Binding Site in The P38 Alpha Map Kinase
  150. 2no3: Novel 4-anilinopyrimidines as Potent Jnk1 Inhibitors
  151. 2gmx: Selective Aminopyridine-based C-jun N-terminal Kinase Inhibitors with Cellular Activity
  152. 2gph: Docking Motif Interactions in The Map Kinase Erk2
  153. 5z33: Crystal Structure of Mitogen-activated Protein Kinase Mps1 in Magnaporthe Oryzae
  154. 2gtm: Mutated Mouse P38 Map Kinase Domain in Complex with Inhibitor Pg-892579
  155. 2gtn: Mutated Map Kinase P38 (mus Musculus) in Complex with Inhbitor Pg-951717
  156. 2h96: Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun Nh2-terminal Kinase Inhibitors
  157. 2i0h: The Structure of P38ALPHA in Complex with an Arylpyridazinone
  158. 6tca: Phosphorylated P38 and Mapkapk2 Complex with Inhibitor
  159. 5ra1: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N08141B in Complex with Map Kinase P38-alpha
  160. 5ra0: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13421A in Complex with Map Kinase P38-alpha
  161. 5r9z: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13502A in Complex with Map Kinase P38-alpha
  162. 5r9y: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13619A in Complex with Map Kinase P38-alpha
  163. 5r9x: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13611A in Complex with Map Kinase P38-alpha
  164. 5r9w: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13598A in Complex with Map Kinase P38-alpha
  165. 5r9v: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13596A in Complex with Map Kinase P38-alpha
  166. 5r9u: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13475A in Complex with Map Kinase P38-alpha
  167. 5r9t: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13477A in Complex with Map Kinase P38-alpha
  168. 5r9s: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13470A in Complex with Map Kinase P38-alpha
  169. 5r9r: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13413A in Complex with Map Kinase P38-alpha
  170. 5r9q: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N07422B in Complex with Map Kinase P38-alpha
  171. 5r9p: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13430A in Complex with Map Kinase P38-alpha
  172. 5r9o: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N06122B in Complex with Map Kinase P38-alpha
  173. 5r9n: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13421A in Complex with Map Kinase P38-alpha
  174. 5r9m: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13418A in Complex with Map Kinase P38-alpha
  175. 5r9l: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N14274A in Complex with Map Kinase P38-alpha
  176. 5r9k: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N14246A in Complex with Map Kinase P38-alpha
  177. 5r9j: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N14231A in Complex with Map Kinase P38-alpha
  178. 5r9i: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Tcj795 in Complex with Map Kinase P38-alpha
  179. 5r9h: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Tcj658 in Complex with Map Kinase P38-alpha
  180. 5r9g: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Pc587 in Complex with Map Kinase P38-alpha
  181. 5r9f: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13724A in Complex with Map Kinase P38-alpha
  182. 5r9e: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13693A in Complex with Map Kinase P38-alpha
  183. 5r9d: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment S00888C in Complex with Map Kinase P38-alpha
  184. 5r9c: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N14074A in Complex with Map Kinase P38-alpha
  185. 5r9b: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13866A in Complex with Map Kinase P38-alpha
  186. 5r9a: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13838A in Complex with Map Kinase P38-alpha
  187. 5r99: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13619A in Complex with Map Kinase P38-alpha
  188. 5r98: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N14109A in Complex with Map Kinase P38-alpha
  189. 5r97: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13662A in Complex with Map Kinase P38-alpha
  190. 5r96: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Kcl095 in Complex with Map Kinase P38-alpha
  191. 5r95: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Kcl093 in Complex with Map Kinase P38-alpha
  192. 5r94: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Kcl081 in Complex with Map Kinase P38-alpha
  193. 5r93: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Kcl077 in Complex with Map Kinase P38-alpha
  194. 5r92: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Kcl063 in Complex with Map Kinase P38-alpha
  195. 5r91: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Kcl057 in Complex with Map Kinase P38-alpha
  196. 5r90: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N11145A in Complex with Map Kinase P38-alpha
  197. 5r8z: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N01381C in Complex with Map Kinase P38-alpha
  198. 5r8y: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N08078B in Complex with Map Kinase P38-alpha
  199. 5r8x: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N11396A in Complex with Map Kinase P38-alpha
  200. 5r8w: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment K00283C in Complex with Map Kinase P38-alpha
  201. 5r8v: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N09139B in Complex with Map Kinase P38-alpha
  202. 5r8u: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N05703B in Complex with Map Kinase P38-alpha
  203. 3o17: Crystal Structure of Jnk1-alpha1 Isoform
  204. 3o2m: Crystal Structure of Jnk1-alpha1 Isoform Complex with a Biaryl Tetrazol (a-82118)
  205. 3od6: Crystal Structure of P38ALPHA Y323T Active Mutant
  206. 3ody: Crystal Structure of P38ALPHA Y323Q Active Mutant
  207. 3odz: Crystal Structure of P38ALPHA Y323R Active Mutant
  208. 3oef: Crystal Structure of Y323F Inactive Mutant of P38ALPHA Map Kinase
  209. 3p4k: The Third Conformation of P38A Map Kinase Observed in Phosphorylated P38A and in Solution
  210. 3ptg: Design and Synthesis of a Novel, Orally Efficacious Tri-substituted Thiophene Based Jnk Inhibitor
  211. 6v6a: Inhibitory Scaffolding of The Ancient Mapk, Erk7
  212. 6rfo: Erk2 Map Kinase with The Activation Loop of P38ALPHA
  213. 5ra7: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N11351A in Complex with Map Kinase P38-alpha
  214. 5ra8: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N05711B in Complex with Map Kinase P38-alpha
  215. 3lfa: Human P38 Map Kinase in Complex with Dasatinib
  216. 3lfb: Human P38 Map Kinase in Complex with Rl98
  217. 3lfc: Human P38 Map Kinase in Complex with Rl99
  218. 3lfd: Human P38 Map Kinase in Complex with Rl113
  219. 3lfe: Human P38 Map Kinase in Complex with Rl116
  220. 3lff: Human P38 Map Kinase in Complex with Rl166
  221. 3mw1: P38 Kinase Crystal Structure in Complex with Small Molecule Inhibitor
  222. 6rfp: Erk2 Map Kinase with Mutations at Helix-g
  223. 3py3: Crystal Structure of Phosphorylated P38ALPHA Map Kinase
  224. 3oxi: Design and Synthesis of Disubstituted Thiophene and Thiazole Based Inhibitors of Jnk for The Treatment of Neurodegenerative Diseases
  225. 6yk7: Crystal Structure of P38 in Complex with Sr43
  226. 6ycw: Fragment Kcl_k767 in Complex with Map Kinase P38-alpha
  227. 6ycu: Fragment Kcl_k777 in Complex with Map Kinase P38-alpha
  228. 6qyx: P38(alpha) Map Kinase with The Activation Loop of Erk2
  229. 3o71: Crystal Structure of Erk2/dcc Peptide Complex
  230. 6y8h: Novel P38-alpha Crystal Lattice with Highly Exposed P38/tab1 Non- Canonical Ppi Surface.
  231. 6y85: Fragment Kcl_1410 in Complex with Map Kinase P38-alpha
  232. 6y82: Fragment Kcl_804 in Complex with Map Kinase P38-alpha
  233. 6y81: Fragment Kcl_1088 in Complex with Map Kinase P38-alpha
  234. 6y80: Fragment Kcl_916 in Complex with Map Kinase P38-alpha
  235. 6y7z: Fragment Kcl_914 in Complex with Map Kinase P38-alpha
  236. 6y7y: Fragments Kcl_771 and Kcl_802 in Complex with Map Kinase P38-alpha
  237. 6y7x: Fragment Kcl_771 in Complex with Map Kinase P38-alpha
  238. 6y7w: Fragment Kcl_1337 in Complex with Map Kinase P38-alpha
  239. 6y6v: P38A Bound with Mcp-81
  240. 3roc: Crystal Structure of Human P38 Alpha Complexed with a Pyrimidinone Compound
  241. 3rp9: Crystal Structure of The Apo Mapk from Toxoplasma Gondii, 25.m01780 or Tgme49_007820
  242. 6y4u: Crystal Structure of P38 in Complex with Sr65
  243. 6una: Crystal Structure of Inactive P38GAMMA
  244. 3oy1: Highly Selective C-jun N-terminal Kinase (jnk) 2 and 3 Inhibitors with in Vitro Cns-like Pharmacokinetic Properties
  245. 3r63: Structure of Erk2 (spe) Mutant (S246E)
  246. 3qyw: Crystal Structure of Erk2 in Complex with an Inhibitor
  247. 3qyz: Crystal Structure of Erk2 in Complex with an Inhibitor
  248. 6y4t: Crystal Structure of P38 in Complex with Sr43
  249. 2xrw: Linear Binding Motifs for Jnk and for Calcineurin Antagonistically Control The Nuclear Shuttling of Nfat4
  250. 2xs0: Linear Binding Motifs for Jnk and for Calcineurin Antagonistically Control The Nuclear Shuttling of Nfat4
  251. 3p78: P38 Inhibitor-bound
  252. 3p79: P38 Inhibitor-bound
  253. 3p7a: P38 Inhibitor-bound
  254. 3p7b: P38 Inhibitor-bound
  255. 3p7c: P38 Inhibitor-bound
  256. 6spl: Fragment Kcl615 in Complex with Map Kinase P38-alpha
  257. 6sp9: Fragment Kcl802 in Complex with Map Kinase P38-alpha
  258. 6sov: Fragments Kcl_615 and Kcl_802 in Complex with Map Kinase P38-alpha
  259. 6sou: Fragment N13565A in Complex with Map Kinase P38-alpha
  260. 6sot: Fragment N11290A in Complex with Map Kinase P38-alpha
  261. 6soi: Fragment N13788A in Complex with Map Kinase P38-alpha
  262. 6sod: Fragment N14056A in Complex with Map Kinase P38-alpha
  263. 6so4: Fragment Rz132 in Complex with Map Kinase P38-alpha
  264. 6so2: Fragment N13460A in Complex with Map Kinase P38-alpha
  265. 6so1: Fragment N13569A in Complex with Map Kinase P38-alpha
  266. 6slg: Human Erk2 with Erk1/2 Inhibitor, Azd0364.
  267. 6sfo: Mapk14 with Bound Inhibitor Sr-318
  268. 6sfk: Crystal Structure of P38 Alpha in Complex with Compound 81 (mcp42)
  269. 6sfj: Crystal Structure of P38 Alpha in Complex with Compound 77 (mcp41)
  270. 6sfi: Crystal Structure of P38 Alpha in Complex with Compound 75 (mcp33)
  271. 3p5k: P38 Inhibitor-bound
  272. 3pg3: Human P38 Map Kinase in Complex with Rl182
  273. 6rq4: Inhibitor of Erk2
  274. 2yis: Triazolopyridine Inhibitors of P38 Kinase.
  275. 2yiw: Triazolopyridine Inhibitors of P38 Kinase
  276. 2yix: Triazolopyridine Inhibitors of P38
  277. 3pze: Jnk1 in Complex with Inhibitor
  278. 3sa0: Complex of Erk2 with Norathyriol
  279. 3zya: Human P38 Map Kinase in Complex with 2-amino-phenylamino- Dibenzosuberone
  280. 6qaw: Erk2 Mini-fragment Binding
  281. 6qaq: Erk2 Mini-fragment Binding
  282. 6qal: Erk2 Mini-fragment Binding
  283. 6qah: Erk2 Mini-fragment Binding
  284. 3que: Human P38 Map Kinase in Complex with Skepinone-l
  285. 6qag: Erk2 Mini-fragment Binding
  286. 6qa4: Erk2 Mini-fragment Binding
  287. 6qa3: Erk2 Mini-fragment Binding
  288. 6qa1: Erk2 Mini-fragment Binding
  289. 6q7t: Erk2 Mini-fragment Binding
  290. 6q7s: Erk2 Mini-fragment Binding
  291. 6q7k: Erk2 Mini-fragment Binding
  292. 3ttj: Crystal Structure of Jnk3 Complexed with Cc-359, a Jnk Inhibitor for The Prevention of Ischemia-reperfusion Injury
  293. 3s4q: P38 Alpha Kinase Complexed with a Pyrazolo-triazine Based Inhibitor
  294. 3tti: Crystal Structure of Jnk3 Complexed with Cc-930, an Orally Active Anti-fibrotic Jnk Inhibitor
  295. 3v6r: Discovery of Potent and Selective Covalent Inhibitors of Jnk
  296. 3v6s: Discovery of Potent and Selective Covalent Inhibitors of Jnk
  297. 2y8o: Crystal Structure of Human P38ALPHA Complexed with a Mapk Docking Peptide
  298. 2y9q: Crystal Structure of Human Erk2 Complexed with a Mapk Docking Peptide
  299. 3rin: P38 Kinase Crystal Structure in Complex with Small Molecule Inhibitor
  300. 3tg1: Crystal Structure of P38ALPHA in Complex with a Mapk Docking Partner
  301. 6ots: Rat Erk2 E320K
  302. 6ot6: Rat Erk2 D319N
  303. 6opk: Phosphorylated Erk2 with Vertex-11e
  304. 6opi: Phosphorylated Erk2 with Sch-cpd336
  305. 6oph: Phosphorylated Erk2 with Gdc-0994
  306. 6opg: Phosphorylated Erk2 with Amp-pnp
  307. 6ohd: P38 in Complex with T-3220137
  308. 3qud: Human P38 Map Kinase in Complex with 2-amino-phenylamino-benzophenone
  309. 3s3i: P38 Kinase Crystal Structure in Complex with Small Molecule Inhibitor
  310. 6y4w: Crystal Structure of P38 in Complex with Sr69
  311. 4a9y: P38ALPHA Map Kinase Bound to Cmpd 8
  312. 4aa0: P38ALPHA Map Kinase Bound to Cmpd 2
  313. 4aa4: P38ALPHA Map Kinase Bound to Cmpd 22
  314. 4aa5: P38ALPHA Map Kinase Bound to Cmpd 33
  315. 4aac: P38ALPHA Map Kinase Bound to Cmpd 29
  316. 6nbs: Wt Erk2 with Compound 2507-8
  317. 3zsg: X-ray Structure of P38ALPHA Bound to Tak-715
  318. 3zsh: X-ray Structure of P38ALPHA Bound to Scio-469
  319. 3zsi: X-ray Structure of P38ALPHA Bound to Vx-745
  320. 3zs5: Structural Basis for Kinase Selectivity of Three Clinical P38ALPHA Inhibitors
  321. 3zu7: Crystal Structure of a Designed Selected Ankyrin Repeat Protein in Complex with The Map Kinase Erk2
  322. 3zuv: Crystal Structure of a Designed Selected Ankyrin Repeat Protein in Complex with The Phosphorylated Map Kinase Erk2
  323. 4ewq: Human P38 Alpha Mapk in Complex with a Pyridazine Based Inhibitor
  324. 2lgc: Joint Nmr and X-ray Refinement Reveals The Structure of a Novel Dibenzo[a,d]cycloheptenone Inhibitor/p38 Map Kinase Complex in Solution
  325. 6m9l: Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one Based P38 Map Kinase Inhibitors by Scaffold Hopping - Compound 10
  326. 6m95: Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one Based P38 Map Kinase Inhibitors by Scaffold Hopping: Compound 1
  327. 6qdz: P38 Alpha Complex with Ar117045
  328. 6qe1: P38 Alpha Complex with Ar117046
  329. 3tei: Crystal Structure of Human Erk2 Complexed with a Mapk Docking Peptide
  330. 4fux: Crystal Structure of The Erk2 Complexed with E75
  331. 4fuy: Crystal Structure of The Erk2 Complexed with Ek2
  332. 4fv0: Crystal Structure of The Erk2 Complexed with Ek3
  333. 4fv1: Crystal Structure of The Erk2 Complexed with Ek4
  334. 3u8w: Crystal Structure of P38A Mitogen-activated Protein Kinase in Complex with a Triazolopyridazinone Inhibitor
  335. 4b99: Crystal Structure of Mapk7 (erk5) with Inhibitor
  336. 4fv2: Crystal Structure of The Erk2 Complexed with Ek5
  337. 4fv3: Crystal Structure of The Erk2 Complexed with Ek6
  338. 4fv4: Crystal Structure of The Erk2 Complexed with Ek7
  339. 4fv5: Crystal Structure of The Erk2 Complexed with Ek9
  340. 4fv6: Crystal Structure of The Erk2 Complexed with E57
  341. 4fv7: Crystal Structure of The Erk2 Complexed with E94
  342. 4fv8: Crystal Structure of The Erk2 Complexed with E63
  343. 4fv9: Crystal Structure of The Erk2 Complexed with E71
  344. 4g6n: Crystal Structure of The Erk2
  345. 4g6o: Crystal Structure of The Erk2
  346. 4gsb: Monoclinic Crystal Form of The Apo-erk2
  347. 4gt3: Atp-bound Form of The Erk2 Kinase
  348. 4gva: Adp-bound Form of The Erk2 Kinase
  349. 4e5a: The W197A Mutant of P38A Map Kinase
  350. 4e5b: Structure of P38A Map Kinase without Bog
  351. 4e6a: P38A-PIA23 Complex
  352. 4e6c: P38A-PERIFOSINE Complex
  353. 4e8a: The Crystal Structure of P38A Map Kinase in Complex with Pia24
  354. 4fmq: Crystal Structure of Human Erk2 Complexed with a Mapk Docking Peptide
  355. 3uvp: Human P38 Map Kinase in Complex with Km048
  356. 3uvq: Human P38 Map Kinase in Complex with Fs218
  357. 3v3v: Structural and Functional Analysis of Quercetagetin, a Natural Jnk1 Inhibitor
  358. 6hwv: Crystal Structure of P38ALPHA in Complex with a Photoswitchable 2- Azoimidazol-based Inhibitor (compound 3)
  359. 6hwu: Crystal Structure of P38ALPHA in Complex with a Photoswitchable 2- Azothiazol-based Inhibitor (compound 2)
  360. 6hwt: Crystal Structure of P38ALPHA in Complex with a Reduced Photoswitchable 2-azothiazol-based Inhibitor (compound 31)
  361. 4eh2: Human P38 Map Kinase in Complex with Np-f1 and Rl87
  362. 4eh3: Human P38 Map Kinase in Complex with Np-f2 and Rl87
  363. 4eh4: Human P38 Map Kinase in Complex with Np-f3 and Rl87
  364. 4eh5: Human P38 Map Kinase in Complex with Np-f4 and Rl87
  365. 4eh6: Human P38 Map Kinase in Complex with Np-f5 and Rl87
  366. 4eh7: Human P38 Map Kinase in Complex with Np-f6 and Rl87
  367. 4eh8: Human P38 Map Kinase in Complex with Np-f7 and Rl87
  368. 4eh9: Human P38 Map Kinase in Complex with Np-f11 and Rl87
  369. 4ehv: Human P38 Map Kinase in Complex with Np-f10 and Rl87
  370. 4h36: Crystal Structure of Jnk3 in Complex with Atf2 Peptide
  371. 4h39: Crystal Structure of Jnk3 in Complex with Jip1 Peptide
  372. 4h3b: Crystal Structure of Jnk3 in Complex with Sab Peptide
  373. 3uvr: Human P38 Map Kinase in Complex with Km064
  374. 3vud: Crystal Structure of a Cysteine-deficient Mutant M1 in Map Kinase Jnk1
  375. 3vug: Crystal Structure of a Cysteine-deficient Mutant M2 in Map Kinase Jnk1
  376. 3vuh: Crystal Structure of a Cysteine-deficient Mutant M3 in Map Kinase Jnk1
  377. 3vui: Crystal Structure of a Cysteine-deficient Mutant M2 in Map Kinase Jnk1
  378. 3vuk: Crystal Structure of a Cysteine-deficient Mutant M5 in Map Kinase Jnk1
  379. 3vul: Crystal Structure of a Cysteine-deficient Mutant M1 in Map Kinase Jnk1
  380. 3vum: Crystal Structure of a Cysteine-deficient Mutant M7 in Map Kinase Jnk1
  381. 3w55: The Structure of Erk2 in Complex with Fr148083
  382. 4dli: Human P38 Map Kinase in Complex with Rl87
  383. 4dlj: Human P38 Map Kinase in Complex with Rl163
  384. 4eyj: Mapk13 Complex with Inhibitor
  385. 4eym: Mapk13 Complex with Inhibitor
  386. 4h3p: Crystal Structure of Human Erk2 Complexed with a Mapk Docking Peptide
  387. 4h3q: Crystal Structure of Human Erk2 Complexed with a Mapk Docking Peptide
  388. 6hkn: Crystal Structure of Compound 35 with Erk5
  389. 6hkm: Crystal Structure of Compound 1 with Erk5
  390. 4ic7: Crystal Structure of The Erk5 Kinase Domain in Complex with an Mkk5 Binding Fragment
  391. 4ic8: Crystal Structure of The Apo Erk5 Kinase Domain
  392. 4iz5: Structure of The Complex between Erk2 Phosphomimetic Mutant and Pea-15
  393. 4iz7: Structure of Non-phosphorylated Erk2 Bound to The Pea-15 Death Effector Domain
  394. 4iza: Structure of Dually Phosphorylated Erk2 Bound to The Pea-15 Death Effector Domain
  395. 3rtp: Design and Synthesis of Brain Penetrant Selective Jnk Inhibitors with Improved Pharmacokinetic Properties for The Prevention of Neurodegeneration
  396. 4awi: Human JNK1ALPHA Kinase with 4-phenyl-7-azaindole Ikk2 Inhibitor.
  397. 6gjd: Erk2 Signalling Protein
  398. 6gjb: Erk2 Signalling Protein
  399. 6ges: Crystal Structure of Erk1 Covalently Bound to Sm1-71
  400. 6ge0: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
  401. 6gdq: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
  402. 6gdm: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
  403. 6g9n: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
  404. 6g9m: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
  405. 6g9k: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
  406. 6g9j: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
  407. 6g9h: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
  408. 6g9d: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
  409. 6g9a: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
  410. 6g97: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
  411. 6g93: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
  412. 6g92: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
  413. 6g91: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
  414. 6g8x: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
  415. 6g54: Crystal Structure of Erk2 Covalently Bound to Sm1-71
  416. 4e73: Crystal Structure of JNK1BETA-JIP in Complex with an Azaquinolone Inhbitor
  417. 4f9w: Human P38ALPHA Mapk in Complex with a Novel and Selective Small Molecule Inhibitor
  418. 6fxv: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
  419. 4f9y: Human P38 Alpha Mapk in Complex with a Novel and Selective Small Molecule Inhibitor
  420. 4fa2: Human P38 Alpha Mitogen-activated Kinase in Complex with Sb239063
  421. 4geo: P38A Map Kinase Def-pocket Penta Mutant (M194A, L195A, H228A, I229A, Y258A)
  422. 6frp: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
  423. 6fr1: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
  424. 6fq7: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
  425. 6fn5: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
  426. 6fma: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
  427. 6flv: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
  428. 6fle: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
  429. 6fjz: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
  430. 6fjb: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
  431. 6fj0: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
  432. 4kin: Crystal Structure of Mitogen-activated Protein Kinase 14 (p38-h5) Complex with 5-(2-chlorophenyl)-n-(5-(cyclopropylcarbamoyl)-2- Methylphenyl)-2-thiophenecarboxamide
  433. 4kip: Crystal Structure of Mitogen-activated Protein Kinase 14 (p38-h5) Complex with 2-(2-chlorophenyl)-n-(5-(cyclopropylcarbamoyl)-2- Methylphenyl)-1,3-thiazole-5-carboxamide
  434. 4kiq: Crystal Structure of Mitogen-activated Protein Kinase 14 (p38-h5) Complex with Ethyl 6-((5-(cyclopropylcarbamoyl)-2-methylphenyl) Carbamoyl)-1h-indole-1-carboxylate
  435. 6fi6: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
  436. 6fi3: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
  437. 4ka3: Structure of Map Kinase in Complex with a Docking Peptide
  438. 6f5e: Crystal Structure of Darpin-darpin Rigid Fusion, Variant Dd_d12_10_47 in Complex JNK1A1 and Jip1 Peptide
  439. 4i5h: Crystal Structure of a Double Mutant Rat Erk2 Complexed with a Type II Quinazoline Inhibitor
  440. 6eq9: Crystal Structure of Jnk3 in Complex with Amp-pcp
  441. 6emh: Crystal Structure of Jnk3 in Complex with a Pyridinylimidazole Inhibitor
  442. 6ekd: Crystal Structure of Jnk3 in Complex with a Pyridinylimidazole Inhibitor
  443. 6dtl: Mitogen-activated Protein Kinase 6
  444. 6dmg: A Multiconformer Ligand Model of Ek6 Bound to Erk2
  445. 6dcg: Discovery of Mk-8353: an Orally Bioavailable Dual Mechanism Erk Inhibitor for Oncology
  446. 6d5y: Crystal Structure of Erk2 G169D Mutant
  447. 5ra4: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N11337A in Complex with Map Kinase P38-alpha
  448. 5ra3: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N10836B in Complex with Map Kinase P38-alpha
  449. 5ra2: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N09036B in Complex with Map Kinase P38-alpha
  450. 5ra6: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N11338A in Complex with Map Kinase P38-alpha
  451. 6cpw: Discovery of 3(s)-thiomethyl Pyrrolidine Erk Inhibitors for Oncology
  452. 5ra5: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N11302A in Complex with Map Kinase P38-alpha
  453. 5ra9: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N08051B in Complex with Map Kinase P38-alpha
  454. 4kke: The Crystal Structure of Amp-bound Jnk3
  455. 4kkg: Crystal Structure of Apo and Amp-bound Jnk3
  456. 4kkh: The Crystal Structure of Inhibitor-bound Jnk3
  457. 4l7f: Co-crystal Structure of Jnk1 and Ax13587
  458. 4l8m: Human P38 Map Kinase in Complex with a Dibenzoxepinone
  459. 4loo: Structural Basis of Autoactivation of P38 Alpha Induced by Tab1 (monoclinic Crystal Form)
  460. 4lop: Structural Basis of Autoactivation of P38 Alpha Induced by Tab1 (tetragonal Crystal Form)
  461. 4loq: Structural Basis of Autoactivation of P38 Alpha Induced by Tab1 (tetragonal Crystal Form with Bound Sulphate)
  462. 4n0s: Complex of Erk2 with Caffeic Acid
  463. 4n4s: A Double Mutant Rat Erk2 in Complex with a Pyrazolo[3,4-d]pyrimidine Inhibitor
  464. 4nif: Heterodimeric Structure of Erk2 and Rsk1
  465. 4o6e: Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine Inhibitors of Erk2
  466. 5xyy: The Structure of P38 Alpha in Complex with a Triazol Inhibitor
  467. 5xyx: The Structure of P38 Alpha in Complex with a Triazol Inhibitor
  468. 5wp1: Complex of Erk2 with 5,7-dihydroxychromone
  469. 5wjj: Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based P38 Map Kinase Inhibitors
  470. 4qta: Structure of Human Erk2 in Complex with Sch772984 Revealing a Novel Inhibitor-induced Binding Pocket
  471. 4qtb: Structure of Human Erk1 in Complex with Sch772984 Revealing a Novel Inhibitor-induced Binding Pocket
  472. 4qtd: Structure of Human Jnk1 in Complex with Sch772984 and The Amppnp- Hydrolysed Triphosphate Revealing The Second Type-i Binding Mode
  473. 4qte: Structure of Erk2 in Complex with Vtx-11e, 4-{2-[(2-chloro-4- Fluorophenyl)amino]-5-methylpyrimidin-4-yl}-n-[(1s)-1-(3- Chlorophenyl)-2-hydroxyethyl]-1h-pyrrole-2-carboxamide
  474. 4qyy: Discovery of Novel, Dual Mechanism Erk Inhibitors by Affinity Selection Screening of an Inactive Kinase State
  475. 4u79: Crystal Structure of Human Jnk3 in Complex with a Benzenesulfonamide Inhibitor.
  476. 5v62: Phospho-erk2 Bound to Bivalent Inhibitor Sbp3
  477. 5v61: Phospho-erk2 Bound to Bivalent Inhibitor Sbp2
  478. 5v60: Phospho-erk2 Bound to Amp-pcp
  479. 4whz: Design and Synthesis of Highly Potent and Isoform Selective Jnk3 Inhibitors: Sar Studies on Aminopyrazole Derivatives
  480. 5uoj: The Structure of The Map Kinase P38 at 2.1 Angstroms Resolution
  481. 5umo: Structure of Extracellular Signal-regulated Kinase
  482. 4qum: Crystal Structure of Ptpn3 (ptph1) in Complex with a Dually Phosphorylated Mapk12 Peptide
  483. 5u6i: Discovery of Mli-2, an Orally Available and Selective Lrrk2 Inhibitor That Reduces Brain Kinase Activity
  484. 5tco: Human P38 Map Kinase in Complex with Dibenzosuberone Compound 1
  485. 5tbe: Human P38ALPHA Map Kinase in Complex with Dibenzosuberone Compound 2
  486. 5omh: P38ALPHA in Complex with Pyrazolobenzothiazine Inhibitor Coxh11
  487. 5omg: P38ALPHA in Complex with Pyrazolobenzothiazine Inhibitor COXP4M12
  488. 5o90: Crystal Structure of a P38ALPHA T185G Mutant in Complex with Tab1 Peptide.
  489. 5o8v: Covalent Inhibitor 4a Bound to The Lipid Pocket of P38ALPHA Mutant S251C
  490. 5o8u: Covalent Inhibitor 4b Bound to The Lipid Pocket of P38ALPHA Mutant S252C
  491. 5o7i: Erk5 in Complex with a Pyrrole Inhibitor
  492. 5nzz: Crystal Structure of Phosphorylated P38AMAPK in Complex with Tab1
  493. 5nhv: Human Erk2 with an Erk1/2 Inhibitor
  494. 5nhp: Human Erk2 with an Erk1/2 Inhibitor
  495. 5nho: Human Erk2 with an Erk1/2 Inhibitor
  496. 5nhl: Human Erk2 with an Erk1/2 Inhibitor
  497. 5nhj: Human Erk2 with an Erk1/2 Inhibitor
  498. 5nhh: Human Erk2 with an Erk1/2 Inhibitor
  499. 5nhf: Human Erk2 with an Erk1/2 Inhibitor
  500. 5ngu: Human Erk2 with an Erk1/2 Inhibitor
  501. 5n68: Crystal Structure of P38ALPHA in Complex with Lipid Pocket Ligand 9m
  502. 5n67: Crystal Structure of P38ALPHA in Complex with Lipid Pocket Ligand 9l
  503. 5n66: Crystal Structure of P38ALPHA in Complex with Lipid Pocket Ligand 9j
  504. 5n65: Crystal Structure of P38ALPHA in Complex with Lipid Pocket Ligand 9h
  505. 5n64: Crystal Structure of P38ALPHA in Complex with Lipid Pocket Ligand 9g
  506. 5n63: Crystal Structure of P38ALPHA in Complex with Lipid Pocket Ligand 9c
  507. 5mz3: P38 Alpha Mutant C162S in Complex with Cmpd2 [n-(4-methyl-3-(4,4,5,5- Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(trifluoromethyl) Benzamide]
  508. 5mty: Dibenzosuberone Inhibitor 8e in Complex with P38 Mapk
  509. 5mtx: Dibenzooxepinone Inhibitor 12b in Complex with P38 Mapk
  510. 5ml5: Human P38ALPHA Mapk in Complex with Imidazolyl Pyridine Inhibitor 11b
  511. 5lw1: Crystal Structure of Darpin-darpin Rigid Fusion, Variant Dd_232_11_d12 in Complex JNK1A1 and Jip1 Peptide
  512. 5lck: A Clickable Covalent Erk 1/2 Inhibitor
  513. 5lcj: In-gel Activity-based Protein Profiling of a Clickable Covalent Erk 1/2 Inhibitor
  514. 5lar: Crystal Structure of P38 Alpha Mapk14 in Complex with Vpc00628
  515. 5ke0: Discovery of 1-1h-pyrazolo 4,3-c Pyridine-6-yl Urea Inhibitors of Extracellular Signal Regulated Kinase Erk for The Treatment of Cancers
  516. 5k4i: Crystal Structure of Erk2 in Complex with Compound 22
  517. 5hd7: Dissecting Therapeutic Resistance to Erk Inhibition Rat Mutant Sch772984 in Complex with (3r)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl) Phenyl]piperazin-1-yl}ethyl)-n-[3-(pyridin-4-yl)-2h-indazol-5- Yl]pyrrolidine-3-carboxamide
  518. 5hd4: Dissecting Therapeutic Resistance to Erk Inhibition Rat Wild Type Sch772984 in Complex with (3r)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl) Phenyl]piperazin-1-yl}ethyl)-n-[3-(pyridin-4-yl)-2h-indazol-5- Yl]pyrrolidine-3-carboxamide
  519. 5eti: Structure of Dead Kinase Mapk14
  520. 5etf: Structure of Dead Kinase Mapk14 with Bound The Kim Domain of Mkk6
  521. 5etc: Structure of Inactive Mapk14 with Ordered Activation Loop
  522. 5eta: Structure of Mapk14 with Bound The Kim Domain of The Toxoplasma Protein Gra24
  523. 5eko: Crystal Structure of Mapk13 Complex with Inhibitor
  524. 5ekn: Crystal Structure of Mapk13 Complex with Inhibitor
  525. 5ci6: Crystal Structure of Arabidopsis Thaliana Mpk6
  526. 5byz: Erk5 in Complex with Small Molecule
  527. 5byy: Erk5 in Complex with Small Molecule
  528. 5bvf: Tetrahydropyrrolo-diazepenones as Inhibitors of Erk2 Kinase
  529. 5bve: Tetrahydropyrrolo-diazepenones as Inhibitors of Erk2 Kinase
  530. 5bvd: Tetrahydropyrrolo-diazepenones as Inhibitors of Erk2 Kinase
  531. 5buj: Erk2 Complexed with a N-h Tetrahydroazaindazole
  532. 5bui: Erk2 Complexed with 2-pyridiyl Tetrahydroazaindazole
  533. 5bue: Erk2 Complexed with N-benzylpyridone Tetrahydroazaindazole
  534. 5ax3: Crystal Structure of Erk2 Complexed with Allosteric and Atp- Competitive Inhibitors.
  535. 5awm: The Crystal Structure of Jnk from Drosophila Melanogaster Reveals an Evolutionarily Conserved Topology with That of Mammalian Jnk Proteins.
  536. 4w4v: Jnk2/3 in Complex with 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1h- Pyrazol-1-yl)-n-(2-methylpyridin-4-yl)benzamide
  537. 4w4w: Jnk2/3 in Complex with N-(2-methylpyridin-4-yl)-3-{4- [(phenylcarbamoyl)amino]-1h-pyrazol-1-yl}benzamide
  538. 4w4x: Jnk2/3 in Complex with 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1h- Pyrazol-1-yl)-n-(2-methylpyridin-4-yl)benzamide
  539. 4w4y: Jnk2/3 in Complex with 3-(4-{[(4-methylphenyl)carbamoyl]amino}-1h- Pyrazol-1-yl)-n-(2-methylpyridin-4-yl)benzamide
  540. 4zxt: Complex of Erk2 with Catechol
  541. 4zth: Structure of Human P38AMAPK-ARYLPYRIDAZINYLPYRIDINE Fragment Complex Used in Inhibitor Discovery
  542. 4zsl: Mitogen Activated Protein Kinase 7 in Complex with Inhibitor
  543. 4zsj: Mitogen Activated Protein Kinase 7 in Complex with Inhibitor
  544. 4zsg: Mitogen Activated Protein Kinase 7 in Complex with Inhibitor
  545. 4r3c: Crystal Structure of P38 Alpha Map Kinase in Complex with a Novel Isoform Selective Drug Candidate
  546. 4myg: Mapk13, Active Form
  547. 4ux9: Crystal Structure of Jnk1 Bound to a Mkk7 Docking Motif
  548. 4yno: Crystal Structure of Mapk13 at Inactive Form
  549. 4yr8: Crystal Structure of Jnk in Complex with a Regulator Protein
  550. 4y46: Pyridopyrimidinone Derivatives as Potent and Selective C-jun N- Terminal Kinase (jnk) Inhibitors
  551. 4y5h: Pyridopyrimidinone Derivatives as Potent and Selective C-jun N- Terminal Kinase (jnk) Inhibitors
  552. 4z9l: The Structure of Jnk3 in Complex with an Imidazole-pyrimidine Inhibitor
  553. 4zzm: Human Erk2 in Complex with an Irreversible Inhibitor
  554. 4zzn: Human Erk2 in Complex with an Inhibitor
  555. 4zzo: Human Erk2 in Complex with an Irreversible Inhibitor
  556. 4qp1: Crystal Structure of Erk2 in Complex with N-cyclohexyl-9h-purin-6- Amine
  557. 4qp2: Crystal Structure of Erks in Complex with 5-chlorobenzo[d]oxazol-2- Amine
  558. 4qp3: Crystal Structure of Erk2 in Complex with (s)-2-((9h-purin-6-yl) Amino)-3-phenylpropan-1-ol
  559. 4qp4: Crystal Structure of Erk2 in Complex with N-cyclohexyl-9h-purin-6- Amine
  560. 4qp6: Crystal Structure of Erk2 in Complex with 5h-pyrrolo[2,3-b]pyrazine
  561. 4qp7: Crystal Structure of Erk2 in Complex with 2-(1h-pyrazol-4-yl)-5h- Pyrrolo[2,3-b]pyrazine
  562. 4qp8: Crystal Structure of Erk2 in Complex with 2-(1h-pyrazol-4-yl)-7- (pyridin-3-yl)-5h-pyrrolo[2,3-b]pyrazine
  563. 4qp9: Crystal Structure of Erk2 in Complex with 7-(1-propyl-1h-pyrazol-4- Yl)-2-(pyridin-4-yl)-5h-pyrrolo[2,3-b]pyrazine
  564. 4qpa: Crystal Structure of Erk2 in Complex with 7-(1-benzyl-1h-pyrazol-4- Yl)-2-(pyridin-4-yl)-5h-pyrrolo[2,3-b]pyrazine
  565. 4s2z: Erk2 Intrinsically Active Mutant R65S
  566. 4s30: Erk2 Intrinsically Active Mutant (I84A)
  567. 4s31: Crystal Structure of Mitogen-activated Protein Kinase 1 Wterk2 at 1.45a
  568. 4s32: Crystal Structure of Erk2 Amp-pnp Complex
  569. 4s33: Erk2 R65S Mutant Complexed with Amp-pnp
  570. 4s34: Erk2 (I84A) in Complex with Amp-pnp
  571. 4tyh: Ternary Complex of P38 and Mk2 with a P38 Inhibitor
  572. 4x21: The Map Kinase Jnk3 as Target for Halogen Bonding
  573. 4xj0: Crystal Structure of Erk2 in Complex with an Inhibitor 14k
  574. 4xne: Crystal Structure of Erk2 in Complex with an Inhibitor
  575. 4xoy: Crystal Structure of Erk2 in Complex with an Inhibitor
  576. 4xoz: Crystal Structure of Erk2 in Complex with an Inhibitor
  577. 4xp0: Crystal Structure of Erk2 in Complex with an Inhibitor
  578. 4xp2: Crystal Structure of Erk2 in Complex with an Inhibitor
  579. 4xp3: Crystal Structure of Erk2 in Complex with an Inhibitor
  580. 4xrj: Crystal Structure of Erk2 in Complex with an Inhibitor
  581. 4xrl: Crystal Structure at Room Temperature of Erk2 in Complex with an Inhibitor
© Copyright 2008-2009 by enzymes.me.uk