EC 2.7.11.24 - ATP:protein phosphotransferase (MAPKK- activated) (mitogen- activated protein kinase)

3D structures of EC 2.7.11.24 - mitogen-activated protein kinase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 6y4v: Crystal Structure of P38 in Complex with Sr68
2. 1lew: Crystal Structure of Map Kinase P38 Complexed to The Docking Site on Its Nuclear Substrate MEF2A
3. 3ocg: P38 Alpha Kinase Complexed with a 5-amino-pyrazole Based Inhibitor
4. 3oc1: Conformational Plasticity of P38 Map Kinase Dfg Motif Mutants in Response to Inhibitor Binding
5. 3obj: Conformational Plasticity of P38 Map Kinase Dfg Mutants in Response to Inhibitor Binding
6. 3obg: Conformational Plasticity of P38 Map Kinase Dfg Mutants in Response to Inhibitor Binding
7. 3o8u: Conformational Plasticity of P38 Map Kinase Dfg Motif Mutants in Response to Inhibitor Binding
8. 3o8t: Conformational Plasticity of P38 Map Kinase Dfg-motif Mutants in Response to Inhibitor Binding
9. 3o8p: Conformational Plasticity of P38 Map Kinase Dfg Motif Mutants in Response to Inhibitor Binding
10. 3nww: P38 Alpha Kinase Complexed with a 2-aminothiazol-5-yl-pyrimidine Based Inhibitor
11. 3npc: Crystal Structure of Jnk2 Complexed with Birb796
12. 3nnx: Crystal Structure of Phosphorylated P38 Alpha in Complex with Dp802
13. 3nnw: Crystal Structure of P38 Alpha in Complex with Dp802
14. 3nnv: Crystal Structure of P38 Alpha in Complex with Dp437
15. 3nnu: Crystal Structure of P38 Alpha in Complex with Dp1376
16. 3new: P38-alpha Complexed with Compound 10
17. 3mvm: P38 Alpha Map Kinase Complexed with Pyrrolotriazine Inhibitor 7v
18. 3mvl: P38 Alpha Map Kinase Complexed with Pyrrolotriazine Inhibitor 7k
19. 3mpt: Crystal Structure of P38 Kinase in Complex with a Pyrrole-2- Carboxamide Inhibitor
20. 3mpa: Conformational Plasticity of P38 Map Kinase Dfg Motif Mutants in Response to Inhibitor Binding
21. 3mh3: Mutagenesis of P38 Map Kinase Establishes Key Roles of Phe169 in Function and Structural Dynamics and Reveals a Novel Dfg-out State
22. 3mh2: Mutagenesis of P38 Map Kinase Establishes Key Roles of Phe169 in Function and Structural Dynamics and Reveals a Novel Dfg-out State
23. 3mh1: Mutagenesis of P38 Map Kinase Establishes Key Roles of Phe169 in Function and Structural Dynamics and Reveals a Novel Dfg-out State
24. 3mh0: Mutagenesis of P38 Map Kinase Eshtablishes Key Roles of Phe169 in Function and Structural Dynamics and Reveals a Novel Dfg-out State
25. 3mgy: Mutagenesis of P38 Map Kinase Eshtablishes Key Roles of Phe169 in Function and Structural Dynamics and Reveals a Novel Dfg-out State
26. 3lhj: Crystal Structure of P38A Mitogen-activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor.
27. 3l8x: P38 Alpha Kinase Complexed with a Pyrazolo-pyrimidine Based Inhibitor
28. 3l8s: Human P38 Map Kinase in Complex with Cp-547632
29. 3kvx: Jnk3 Bound to Aminopyrimidine Inhibitor, Sr-3562
30. 3kq7: Structure of Human P38ALPHA with N-[4-methyl-3-(6-{[2-(1- Methylpyrrolidin-2-yl)ethyl]amino}pyridine-3-amido)phenyl]- 2-(morpholin-4-yl)pyridine-4-carboxamide
31. 3kf7: Crystal Structure of Human P38ALPHA Complexed with a Triazolopyrimidine Compound
32. 3k3j: P38ALPHA Bound to Novel Dfg-out Compound Pf-00416121
33. 3k3i: P38ALPHA Bound to Novel Dgf-out Compound Pf-00215955
34. 3iw8: Structure of Inactive Human P38 Map Kinase in Complex with a Thiazole-urea
35. 3iw7: Human P38 Map Kinase in Complex with an Imidazo-pyridine
36. 3iw6: Human P38 Map Kinase in Complex with a Benzylpiperazin- Pyrrol
37. 3iw5: Human P38 Map Kinase in Complex with an Indole Derivative
38. 3itz: Crystal Structure of P38A Mitogen-activated Protein Kinase in Complex with a Pyrazolopyridazine Inhibitor
39. 3iph: Crystal Structure of P38 in Complex with a Biphenylamide Inhibitor
40. 3i60: Crystal Structure of Erk2 Bound to (s)-4-(2-(2- Chlorophenylamino)-5-methylpyrimidin-4-yl)-n-(2-hydroxy-1- Phenylethyl)-1h-pyrrole-2-carboxamide
41. 3i5z: Crystal Structure of Erk2 Bound to (s)-n-(2-hydroxy-1- Phenylethyl)-4-(5-methyl-2-(phenylamino)pyrimidin-4-yl)-1h- Pyrrole-2-carboxamide
42. 3hvc: Crystal Structure of Human P38ALPHA Map Kinase
43. 3hv7: Human P38 Map Kinase in Complex with Rl38
44. 3hv6: Human P38 Map Kinase in Complex with Rl39
45. 3hv5: Human P38 Map Kinase in Complex with Rl24
46. 3hv4: Human P38 Map Kinase in Complex with Rl51
47. 3hv3: Human P38 Map Kinase in Complex with Rl49
48. 3huc: Human P38 Map Kinase in Complex with Rl40
49. 3hub: Human P38 Map Kinase in Complex with Scios-469
50. 3hrb: P38 Kinase Crystal Structure in Complex with Small Molecule Inhibitor
51. 3hp5: Crystal Structure of Human P38ALPHA Complexed with a Pyrimidopyridazinone Compound
52. 3hp2: Crystal Structure of Human P38ALPHA Complexed with a Pyridinone Compound
53. 3hll: Crystal Structure of Human P38ALPHA Complexed with Ph-797804
54. 3hl7: Crystal Structure of Human P38ALPHA Complexed with Sd-0006
55. 3heg: P38 in Complex with Sorafenib
56. 3hec: P38 in Complex with Imatinib
57. 3ha8: The Complex Structure of The Map Kinase P38/compound 14b
58. 3gp0: Crystal Structure of Human Mitogen Activated Protein Kinase 11 (p38 Beta) in Complex with Nilotinib
59. 3gi3: Crystal Structure of a N-phenyl-n'-naphthylurea Analog in Complex with P38 Map Kinase
60. 3gfe: Crystal Structure of P38A Mitogen-activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor
61. 3gcv: Human P38 Map Kinase in Complex with Rl62
62. 3gcu: Human P38 Map Kinase in Complex with Rl48
63. 3gcs: Human P38 Map Kinase in Complex with Sorafenib
64. 3gcq: Human P38 Map Kinase in Complex with Rl45
65. 3gcp: Human P38 Map Kinase in Complex with Sb203580
66. 3gc9: The Structure of P38BETA C119S, C162S in Complex with a Dihydroquinazolinone Inhibitor
67. 3gc8: The Structure of P38BETA C162S in Complex with a Dihydroquinazolinone
68. 3gc7: The Structure of P38ALPHA in Complex with a Dihydroquinazolinone
69. 3g9n: Jnk3 Bound to (z)-1-((6-fluoro-4h-benzo[d][1,3]dioxin-8-yl) Methyl)-3-(hydroxyimino)-4-phenylindolin-2-one
70. 3g9l: Jnk3 Bound to (z)-1-((6-fluoro-4h-benzo[d][1,3]dioxin-8-yl) Methyl)-3-(hydroxyimino)-4-styrylindolin-2-one
71. 3g90: Jnk-3 Bound to (z)-5-fluoro-1-((6-fluoro-4h-benzo[d][1, 3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one
72. 3fv8: Jnk3 Bound to Piperazine Amide Inhibitor, Sr2774.
73. 3fsk: P38 Kinase Crystal Structure in Complex with Ro6257
74. 3fsf: P38 Kinase Crystal Structure in Complex with 3-(2,6- Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]- 1-methyl-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one
75. 3fmn: P38 Kinase Crystal Structure in Complex with Ro2530
76. 3fmm: P38 Kinase Crystal Structure in Complex with Ro6226
77. 3fml: P38 Kinase Crystal Structure in Complex with Ro6224
78. 3fmk: P38 Kinase Crystal Structure in Complex with 6-(2,4- Difluoro-phenoxy)-8-methyl-2-((s)-1-methyl-2-tetrazol-2-yl- Ethylamino)-8h-pyrido[2,3-d]pyrimidin-7-one
79. 3fmj: P38 Kinase Crystal Structure in Complex with 4-(5-methyl-3- Phenyl-isoxazol-4-yl)-pyrimidin-2-ylamine
80. 3fmh: P38 Kinase Crystal Structure in Complex with 6-(2,4- Difluoro-phenoxy)-8-methyl-2-((r)-1-methyl-2-tetrazol-2-yl- Ethylamino)-8h-pyrido[2,3-d]pyrimidin-7-one
81. 3flz: P38 Kinase Crystal Structure in Complex with 8-methyl-6- Phenoxy-2-(tetrahydro-pyran-4-ylamino)-8h-pyrido[2,3- D]pyrimidin-7-one
82. 3fly: P38 Kinase Crystal Structure in Complex with 6-(2,4- Difluoro-phenoxy)-2-isopropylamino-8-methyl-8h-pyrido[2,3- D]pyrimidin-7-one
83. 3flw: P38 Kinase Crystal Structure in Complex with Pamapimod
84. 3fls: P38 Kinase Crystal Structure in Complex with 6-(2,4- Difluoro-phenoxy)-2-((r)-2-methanesulfonyl-1-methyl- Ethylamino)-8-methyl-8h-pyrido[2,3-d]pyrimidin-7-one
85. 3flq: P38 Kinase Crystal Structure in Complex with 6-(2,4- Difluoro-phenoxy)-2-((s)-2-methanesulfonyl-1-methyl- Ethylamino)-8-methyl-8h-pyrido[2,3-d]pyrimidin
86. 3fln: P38 Kinase Crystal Structure in Complex with R1487
87. 3fl4: P38 Kinase Crystal Structure in Complex with Ro5634
88. 3fko: P38 Kinase Crystal Structure in Complex with Ro3668
89. 3fkn: P38 Kinase Crystal Structure in Complex with Ro7125
90. 3fkl: P38 Kinase Crystal Structure in Complex with Ro9552
91. 3fi4: P38 Kinase Crystal Structure in Complex with Ro4499
92. 3fi3: Crystal Structure of Jnk3 with Indazole Inhibitor, Sr-3737
93. 3fi2: Crystal Structure of Jnk3 with Amino-pyrazole Inhibitor, Sr- 3451
94. 3fc1: Crystal Structure of P38 Kinase Bound to Pyrimido- Pyridazinone Inhibitor
95. 6y4x: Crystal Structure of P38 in Complex with Sr72
96. 3elj: Jnk1 Complexed with a Bis-anilino-pyrrolopyrimidine Inhibitor.
97. 3e93: Crystal Structure of P38 Kinase in Complex with a Biaryl Amide Inhibitor
98. 3e92: Crystal Structure of P38 Kinase in Complex with a Biaryl Amide Inhibitor
99. 3e7o: Crystal Structure of Jnk2
100. 3dt1: P38 Complexed with a Quinazoline Inhibitor
101. 3ds6: P38 Complex with a Phthalazine Inhibitor
102. 3da6: Crystal Structure of Human Jnk3 Complexed with N-(3-methyl- 4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy) Naphthalen-1-yl)-1h-benzo[d]imidazol-2-amine
103. 3d83: Crystal Structure of P38 Kinase in Complex with a Biphenyl Amide Inhibitor
104. 3d7z: Crystal Structure of P38 Kinase in Complex with a Biphenyl Amide Inhibitor
105. 3ctq: Structure of Map Kinase P38 in Complex with a 1-o-tolyl-1,2, 3-triazole-4-carboxamide
106. 3coi: Crystal Structure of P38DELTA Kinase
107. 3cgo: Irak-4 Inhibitors (part Ii)- a Structure Based Assessment of Imidazo[1,2 A]pyridine Binding
108. 3cgf: Irak-4 Inhibitors (part Ii)- a Structure Based Assessment of Imidazo[1,2 A]pyridine Binding
109. 3c9w: Crystal Structure of Erk-2 with Hypothemycin Covalently Bound
110. 3c5u: P38 Alpha Map Kinase Complexed with a Benzothiazole Based Inhibitor
111. 3bx5: P38 Alpha Map Kinase Complexed with Bms-640994
112. 3bv3: Morpholino Pyrrolotriazine P38 Alpha Map Kinase Inhibitor Compound 2
113. 3bv2: Morpholino Pyrrolotriazine P38 Alpha Map Kinase Inhibitor Compound 30
114. 2zoq: Structural Dissection of Human Mitogen-activated Kinase Erk1
115. 2zdu: Crystal Structure of Human Jnk3 Complexed with an Isoquinolone Inhibitor
116. 2zdt: Crystal Structure of Human Jnk3 Complexed with an Isoquinolone Inhibitor
117. 2zb1: Crystal Structure of P38 in Complex with Biphenyl Amide Inhibitor
118. 2zb0: Crystal Structure of P38 in Complex with Biphenyl Amide Inhibitor
119. 2zaz: Crystal Structure of P38 in Complex with 4-anilino Quinoline Inhibitor
120. 2z7l: Unphosphorylated Mitogen Activated Protein Kinase Erk2 in Complex with (4-{[5-carbamoyl-4-(3-methylanilino)pyrimidin 2-yl]amino}phenyl)acetic Acid
121. 2waj: Crystal Structure of Human Jnk3 Complexed with a 1-aryl-3,4- Dihydroisoquinoline Inhibitor
122. 7cml: The Crystal Structure of Human Jnk2 from Wuxi Biortus.
123. 7aqb: Crystal Structure of Human Mitogen Activated Protein Kinase 6 (mapk6)
124. 6zwr: P38A Bound with Sr92
125. 6zwp: P38A Bound with Sr348
126. 6zr5: Crystal Structure of Jnk1 in Complex with Atf2(19-58)
127. 6zqs: Crystal Structure of Double-phosphorylated P38ALPHA with Atf2(83-102)
128. 2rg6: Phenylalanine Pyrrolotriazine P38 Alpha Map Kinase Inhibitor Compound 11j
129. 2rg5: Phenylalanine Pyrrolotriazine P38 Alpha Map Kinase Inhibitor Compound 11b
130. 2r9s: C-jun N-terminal Kinase 3 with 3,5-disubstituted Quinoline Inhibitor
131. 2qd9: P38 Alpha Map Kinase Inhibitor Based on Heterobicyclic Scaffolds
132. 2q8y: Structural Insight into The Enzymatic Mechanism of The Phophothreonine Lyase
133. 2puu: Crystal Structure of P38 Complex with 1-(5-tert-butyl-2-p- Tolyl-2h-pyrazol-3-yl)-3-[4-(6-morpholin-4-ylmethyl- Pyridin-3-yl)naphthalen-1-yl]urea
134. 2p33: Synthesis and Sar of Aminopyrimidines as Novel C-jun N- Terminal Kinase (jnk) Inhibitors
135. 2oza: Structure of P38ALPHA Complex
136. 2onl: Crystal Structure of The P38A-MAPKAP Kinase 2 Heterodimer
137. 2okr: Crystal Structure of The P38A-MAPKAP Kinase 2 Heterodimer
138. 2ok1: Crystal Structure of Jnk3 Bound to N-benzyl-4-(4-(3- Chlorophenyl)-1h-pyrazol-3-yl)-1h-pyrrole-2-carboxamide
139. 6yll: Biochemical, Cellular and Structural Characterization of Novel Erk3 Inhibitors
140. 6ylc: Biochemical, Cellular and Structural Characterization of Novel Erk3 Inhibitors
141. 2ojj: Crystal Structure of Erk2 in Complex with (s)-n-(1-(3- Chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3- Chlorophenyl)-1h-pyrazol-3-yl)-1h-pyrrole-2-carboxamide
142. 2oji: Crystal Structure of Erk2 in Complex with N-benzyl-4-(4-(3- Chlorophenyl)-1h-pyrazol-3-yl)-1h-pyrrole-2-carboxamide
143. 2ojg: Crystal Structure of Erk2 in Complex with N,n-dimethyl-4-(4- Phenyl-1h-pyrazol-3-yl)-1h-pyrrole-2-carboxamide
144. 6yky: Biochemical, Cellular and Structural Characterization of Novel Erk3 Inhibitors
145. 6yjc: Crystal Structure of P38ALPHA in Complex with Sr154
146. 2o2u: Crystal Structure of Human Jnk3 Complexed with N-(3-cyano-4, 5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
147. 2o0u: Crystal Structure of Human Jnk3 Complexed with N-{3-cyano-6- [3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3- C]pyridin-2-yl}-1-naphthalenecarboxamide
148. 6anl: Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based P38 Map Kinase Inhibitors
149. 2npq: A Novel Lipid Binding Site in The P38 Alpha Map Kinase
150. 2no3: Novel 4-anilinopyrimidines as Potent Jnk1 Inhibitors
151. 2gmx: Selective Aminopyridine-based C-jun N-terminal Kinase Inhibitors with Cellular Activity
152. 2gph: Docking Motif Interactions in The Map Kinase Erk2
153. 5z33: Crystal Structure of Mitogen-activated Protein Kinase Mps1 in Magnaporthe Oryzae
154. 2gtm: Mutated Mouse P38 Map Kinase Domain in Complex with Inhibitor Pg-892579
155. 2gtn: Mutated Map Kinase P38 (mus Musculus) in Complex with Inhbitor Pg-951717
156. 2h96: Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun Nh2-terminal Kinase Inhibitors
157. 2i0h: The Structure of P38ALPHA in Complex with an Arylpyridazinone
158. 6tca: Phosphorylated P38 and Mapkapk2 Complex with Inhibitor
159. 5ra1: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N08141B in Complex with Map Kinase P38-alpha
160. 5ra0: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13421A in Complex with Map Kinase P38-alpha
161. 5r9z: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13502A in Complex with Map Kinase P38-alpha
162. 5r9y: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13619A in Complex with Map Kinase P38-alpha
163. 5r9x: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13611A in Complex with Map Kinase P38-alpha
164. 5r9w: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13598A in Complex with Map Kinase P38-alpha
165. 5r9v: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13596A in Complex with Map Kinase P38-alpha
166. 5r9u: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13475A in Complex with Map Kinase P38-alpha
167. 5r9t: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13477A in Complex with Map Kinase P38-alpha
168. 5r9s: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13470A in Complex with Map Kinase P38-alpha
169. 5r9r: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13413A in Complex with Map Kinase P38-alpha
170. 5r9q: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N07422B in Complex with Map Kinase P38-alpha
171. 5r9p: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13430A in Complex with Map Kinase P38-alpha
172. 5r9o: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N06122B in Complex with Map Kinase P38-alpha
173. 5r9n: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13421A in Complex with Map Kinase P38-alpha
174. 5r9m: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13418A in Complex with Map Kinase P38-alpha
175. 5r9l: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N14274A in Complex with Map Kinase P38-alpha
176. 5r9k: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N14246A in Complex with Map Kinase P38-alpha
177. 5r9j: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N14231A in Complex with Map Kinase P38-alpha
178. 5r9i: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Tcj795 in Complex with Map Kinase P38-alpha
179. 5r9h: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Tcj658 in Complex with Map Kinase P38-alpha
180. 5r9g: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Pc587 in Complex with Map Kinase P38-alpha
181. 5r9f: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13724A in Complex with Map Kinase P38-alpha
182. 5r9e: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13693A in Complex with Map Kinase P38-alpha
183. 5r9d: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment S00888C in Complex with Map Kinase P38-alpha
184. 5r9c: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N14074A in Complex with Map Kinase P38-alpha
185. 5r9b: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13866A in Complex with Map Kinase P38-alpha
186. 5r9a: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13838A in Complex with Map Kinase P38-alpha
187. 5r99: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13619A in Complex with Map Kinase P38-alpha
188. 5r98: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N14109A in Complex with Map Kinase P38-alpha
189. 5r97: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N13662A in Complex with Map Kinase P38-alpha
190. 5r96: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Kcl095 in Complex with Map Kinase P38-alpha
191. 5r95: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Kcl093 in Complex with Map Kinase P38-alpha
192. 5r94: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Kcl081 in Complex with Map Kinase P38-alpha
193. 5r93: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Kcl077 in Complex with Map Kinase P38-alpha
194. 5r92: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Kcl063 in Complex with Map Kinase P38-alpha
195. 5r91: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment Kcl057 in Complex with Map Kinase P38-alpha
196. 5r90: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N11145A in Complex with Map Kinase P38-alpha
197. 5r8z: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N01381C in Complex with Map Kinase P38-alpha
198. 5r8y: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N08078B in Complex with Map Kinase P38-alpha
199. 5r8x: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N11396A in Complex with Map Kinase P38-alpha
200. 5r8w: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment K00283C in Complex with Map Kinase P38-alpha
201. 5r8v: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N09139B in Complex with Map Kinase P38-alpha
202. 5r8u: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N05703B in Complex with Map Kinase P38-alpha
203. 3o17: Crystal Structure of Jnk1-alpha1 Isoform
204. 3o2m: Crystal Structure of Jnk1-alpha1 Isoform Complex with a Biaryl Tetrazol (a-82118)
205. 3od6: Crystal Structure of P38ALPHA Y323T Active Mutant
206. 3ody: Crystal Structure of P38ALPHA Y323Q Active Mutant
207. 3odz: Crystal Structure of P38ALPHA Y323R Active Mutant
208. 3oef: Crystal Structure of Y323F Inactive Mutant of P38ALPHA Map Kinase
209. 3p4k: The Third Conformation of P38A Map Kinase Observed in Phosphorylated P38A and in Solution
210. 3ptg: Design and Synthesis of a Novel, Orally Efficacious Tri-substituted Thiophene Based Jnk Inhibitor
211. 6v6a: Inhibitory Scaffolding of The Ancient Mapk, Erk7
212. 6rfo: Erk2 Map Kinase with The Activation Loop of P38ALPHA
213. 5ra7: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N11351A in Complex with Map Kinase P38-alpha
214. 5ra8: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N05711B in Complex with Map Kinase P38-alpha
215. 3lfa: Human P38 Map Kinase in Complex with Dasatinib
216. 3lfb: Human P38 Map Kinase in Complex with Rl98
217. 3lfc: Human P38 Map Kinase in Complex with Rl99
218. 3lfd: Human P38 Map Kinase in Complex with Rl113
219. 3lfe: Human P38 Map Kinase in Complex with Rl116
220. 3lff: Human P38 Map Kinase in Complex with Rl166
221. 3mw1: P38 Kinase Crystal Structure in Complex with Small Molecule Inhibitor
222. 6rfp: Erk2 Map Kinase with Mutations at Helix-g
223. 3py3: Crystal Structure of Phosphorylated P38ALPHA Map Kinase
224. 3oxi: Design and Synthesis of Disubstituted Thiophene and Thiazole Based Inhibitors of Jnk for The Treatment of Neurodegenerative Diseases
225. 6yk7: Crystal Structure of P38 in Complex with Sr43
226. 6ycw: Fragment Kcl_k767 in Complex with Map Kinase P38-alpha
227. 6ycu: Fragment Kcl_k777 in Complex with Map Kinase P38-alpha
228. 6qyx: P38(alpha) Map Kinase with The Activation Loop of Erk2
229. 3o71: Crystal Structure of Erk2/dcc Peptide Complex
230. 6y8h: Novel P38-alpha Crystal Lattice with Highly Exposed P38/tab1 Non- Canonical Ppi Surface.
231. 6y85: Fragment Kcl_1410 in Complex with Map Kinase P38-alpha
232. 6y82: Fragment Kcl_804 in Complex with Map Kinase P38-alpha
233. 6y81: Fragment Kcl_1088 in Complex with Map Kinase P38-alpha
234. 6y80: Fragment Kcl_916 in Complex with Map Kinase P38-alpha
235. 6y7z: Fragment Kcl_914 in Complex with Map Kinase P38-alpha
236. 6y7y: Fragments Kcl_771 and Kcl_802 in Complex with Map Kinase P38-alpha
237. 6y7x: Fragment Kcl_771 in Complex with Map Kinase P38-alpha
238. 6y7w: Fragment Kcl_1337 in Complex with Map Kinase P38-alpha
239. 6y6v: P38A Bound with Mcp-81
240. 3roc: Crystal Structure of Human P38 Alpha Complexed with a Pyrimidinone Compound
241. 3rp9: Crystal Structure of The Apo Mapk from Toxoplasma Gondii, 25.m01780 or Tgme49_007820
242. 6y4u: Crystal Structure of P38 in Complex with Sr65
243. 6una: Crystal Structure of Inactive P38GAMMA
244. 3oy1: Highly Selective C-jun N-terminal Kinase (jnk) 2 and 3 Inhibitors with in Vitro Cns-like Pharmacokinetic Properties
245. 3r63: Structure of Erk2 (spe) Mutant (S246E)
246. 3qyw: Crystal Structure of Erk2 in Complex with an Inhibitor
247. 3qyz: Crystal Structure of Erk2 in Complex with an Inhibitor
248. 6y4t: Crystal Structure of P38 in Complex with Sr43
249. 2xrw: Linear Binding Motifs for Jnk and for Calcineurin Antagonistically Control The Nuclear Shuttling of Nfat4
250. 2xs0: Linear Binding Motifs for Jnk and for Calcineurin Antagonistically Control The Nuclear Shuttling of Nfat4
251. 3p78: P38 Inhibitor-bound
252. 3p79: P38 Inhibitor-bound
253. 3p7a: P38 Inhibitor-bound
254. 3p7b: P38 Inhibitor-bound
255. 3p7c: P38 Inhibitor-bound
256. 6spl: Fragment Kcl615 in Complex with Map Kinase P38-alpha
257. 6sp9: Fragment Kcl802 in Complex with Map Kinase P38-alpha
258. 6sov: Fragments Kcl_615 and Kcl_802 in Complex with Map Kinase P38-alpha
259. 6sou: Fragment N13565A in Complex with Map Kinase P38-alpha
260. 6sot: Fragment N11290A in Complex with Map Kinase P38-alpha
261. 6soi: Fragment N13788A in Complex with Map Kinase P38-alpha
262. 6sod: Fragment N14056A in Complex with Map Kinase P38-alpha
263. 6so4: Fragment Rz132 in Complex with Map Kinase P38-alpha
264. 6so2: Fragment N13460A in Complex with Map Kinase P38-alpha
265. 6so1: Fragment N13569A in Complex with Map Kinase P38-alpha
266. 6slg: Human Erk2 with Erk1/2 Inhibitor, Azd0364.
267. 6sfo: Mapk14 with Bound Inhibitor Sr-318
268. 6sfk: Crystal Structure of P38 Alpha in Complex with Compound 81 (mcp42)
269. 6sfj: Crystal Structure of P38 Alpha in Complex with Compound 77 (mcp41)
270. 6sfi: Crystal Structure of P38 Alpha in Complex with Compound 75 (mcp33)
271. 3p5k: P38 Inhibitor-bound
272. 3pg3: Human P38 Map Kinase in Complex with Rl182
273. 6rq4: Inhibitor of Erk2
274. 2yis: Triazolopyridine Inhibitors of P38 Kinase.
275. 2yiw: Triazolopyridine Inhibitors of P38 Kinase
276. 2yix: Triazolopyridine Inhibitors of P38
277. 3pze: Jnk1 in Complex with Inhibitor
278. 3sa0: Complex of Erk2 with Norathyriol
279. 3zya: Human P38 Map Kinase in Complex with 2-amino-phenylamino- Dibenzosuberone
280. 6qaw: Erk2 Mini-fragment Binding
281. 6qaq: Erk2 Mini-fragment Binding
282. 6qal: Erk2 Mini-fragment Binding
283. 6qah: Erk2 Mini-fragment Binding
284. 3que: Human P38 Map Kinase in Complex with Skepinone-l
285. 6qag: Erk2 Mini-fragment Binding
286. 6qa4: Erk2 Mini-fragment Binding
287. 6qa3: Erk2 Mini-fragment Binding
288. 6qa1: Erk2 Mini-fragment Binding
289. 6q7t: Erk2 Mini-fragment Binding
290. 6q7s: Erk2 Mini-fragment Binding
291. 6q7k: Erk2 Mini-fragment Binding
292. 3ttj: Crystal Structure of Jnk3 Complexed with Cc-359, a Jnk Inhibitor for The Prevention of Ischemia-reperfusion Injury
293. 3s4q: P38 Alpha Kinase Complexed with a Pyrazolo-triazine Based Inhibitor
294. 3tti: Crystal Structure of Jnk3 Complexed with Cc-930, an Orally Active Anti-fibrotic Jnk Inhibitor
295. 3v6r: Discovery of Potent and Selective Covalent Inhibitors of Jnk
296. 3v6s: Discovery of Potent and Selective Covalent Inhibitors of Jnk
297. 2y8o: Crystal Structure of Human P38ALPHA Complexed with a Mapk Docking Peptide
298. 2y9q: Crystal Structure of Human Erk2 Complexed with a Mapk Docking Peptide
299. 3rin: P38 Kinase Crystal Structure in Complex with Small Molecule Inhibitor
300. 3tg1: Crystal Structure of P38ALPHA in Complex with a Mapk Docking Partner
301. 6ots: Rat Erk2 E320K
302. 6ot6: Rat Erk2 D319N
303. 6opk: Phosphorylated Erk2 with Vertex-11e
304. 6opi: Phosphorylated Erk2 with Sch-cpd336
305. 6oph: Phosphorylated Erk2 with Gdc-0994
306. 6opg: Phosphorylated Erk2 with Amp-pnp
307. 6ohd: P38 in Complex with T-3220137
308. 3qud: Human P38 Map Kinase in Complex with 2-amino-phenylamino-benzophenone
309. 3s3i: P38 Kinase Crystal Structure in Complex with Small Molecule Inhibitor
310. 6y4w: Crystal Structure of P38 in Complex with Sr69
311. 4a9y: P38ALPHA Map Kinase Bound to Cmpd 8
312. 4aa0: P38ALPHA Map Kinase Bound to Cmpd 2
313. 4aa4: P38ALPHA Map Kinase Bound to Cmpd 22
314. 4aa5: P38ALPHA Map Kinase Bound to Cmpd 33
315. 4aac: P38ALPHA Map Kinase Bound to Cmpd 29
316. 6nbs: Wt Erk2 with Compound 2507-8
317. 3zsg: X-ray Structure of P38ALPHA Bound to Tak-715
318. 3zsh: X-ray Structure of P38ALPHA Bound to Scio-469
319. 3zsi: X-ray Structure of P38ALPHA Bound to Vx-745
320. 3zs5: Structural Basis for Kinase Selectivity of Three Clinical P38ALPHA Inhibitors
321. 3zu7: Crystal Structure of a Designed Selected Ankyrin Repeat Protein in Complex with The Map Kinase Erk2
322. 3zuv: Crystal Structure of a Designed Selected Ankyrin Repeat Protein in Complex with The Phosphorylated Map Kinase Erk2
323. 4ewq: Human P38 Alpha Mapk in Complex with a Pyridazine Based Inhibitor
324. 2lgc: Joint Nmr and X-ray Refinement Reveals The Structure of a Novel Dibenzo[a,d]cycloheptenone Inhibitor/p38 Map Kinase Complex in Solution
325. 6m9l: Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one Based P38 Map Kinase Inhibitors by Scaffold Hopping - Compound 10
326. 6m95: Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one Based P38 Map Kinase Inhibitors by Scaffold Hopping: Compound 1
327. 6qdz: P38 Alpha Complex with Ar117045
328. 6qe1: P38 Alpha Complex with Ar117046
329. 3tei: Crystal Structure of Human Erk2 Complexed with a Mapk Docking Peptide
330. 4fux: Crystal Structure of The Erk2 Complexed with E75
331. 4fuy: Crystal Structure of The Erk2 Complexed with Ek2
332. 4fv0: Crystal Structure of The Erk2 Complexed with Ek3
333. 4fv1: Crystal Structure of The Erk2 Complexed with Ek4
334. 3u8w: Crystal Structure of P38A Mitogen-activated Protein Kinase in Complex with a Triazolopyridazinone Inhibitor
335. 4b99: Crystal Structure of Mapk7 (erk5) with Inhibitor
336. 4fv2: Crystal Structure of The Erk2 Complexed with Ek5
337. 4fv3: Crystal Structure of The Erk2 Complexed with Ek6
338. 4fv4: Crystal Structure of The Erk2 Complexed with Ek7
339. 4fv5: Crystal Structure of The Erk2 Complexed with Ek9
340. 4fv6: Crystal Structure of The Erk2 Complexed with E57
341. 4fv7: Crystal Structure of The Erk2 Complexed with E94
342. 4fv8: Crystal Structure of The Erk2 Complexed with E63
343. 4fv9: Crystal Structure of The Erk2 Complexed with E71
344. 4g6n: Crystal Structure of The Erk2
345. 4g6o: Crystal Structure of The Erk2
346. 4gsb: Monoclinic Crystal Form of The Apo-erk2
347. 4gt3: Atp-bound Form of The Erk2 Kinase
348. 4gva: Adp-bound Form of The Erk2 Kinase
349. 4e5a: The W197A Mutant of P38A Map Kinase
350. 4e5b: Structure of P38A Map Kinase without Bog
351. 4e6a: P38A-PIA23 Complex
352. 4e6c: P38A-PERIFOSINE Complex
353. 4e8a: The Crystal Structure of P38A Map Kinase in Complex with Pia24
354. 4fmq: Crystal Structure of Human Erk2 Complexed with a Mapk Docking Peptide
355. 3uvp: Human P38 Map Kinase in Complex with Km048
356. 3uvq: Human P38 Map Kinase in Complex with Fs218
357. 3v3v: Structural and Functional Analysis of Quercetagetin, a Natural Jnk1 Inhibitor
358. 6hwv: Crystal Structure of P38ALPHA in Complex with a Photoswitchable 2- Azoimidazol-based Inhibitor (compound 3)
359. 6hwu: Crystal Structure of P38ALPHA in Complex with a Photoswitchable 2- Azothiazol-based Inhibitor (compound 2)
360. 6hwt: Crystal Structure of P38ALPHA in Complex with a Reduced Photoswitchable 2-azothiazol-based Inhibitor (compound 31)
361. 4eh2: Human P38 Map Kinase in Complex with Np-f1 and Rl87
362. 4eh3: Human P38 Map Kinase in Complex with Np-f2 and Rl87
363. 4eh4: Human P38 Map Kinase in Complex with Np-f3 and Rl87
364. 4eh5: Human P38 Map Kinase in Complex with Np-f4 and Rl87
365. 4eh6: Human P38 Map Kinase in Complex with Np-f5 and Rl87
366. 4eh7: Human P38 Map Kinase in Complex with Np-f6 and Rl87
367. 4eh8: Human P38 Map Kinase in Complex with Np-f7 and Rl87
368. 4eh9: Human P38 Map Kinase in Complex with Np-f11 and Rl87
369. 4ehv: Human P38 Map Kinase in Complex with Np-f10 and Rl87
370. 4h36: Crystal Structure of Jnk3 in Complex with Atf2 Peptide
371. 4h39: Crystal Structure of Jnk3 in Complex with Jip1 Peptide
372. 4h3b: Crystal Structure of Jnk3 in Complex with Sab Peptide
373. 3uvr: Human P38 Map Kinase in Complex with Km064
374. 3vud: Crystal Structure of a Cysteine-deficient Mutant M1 in Map Kinase Jnk1
375. 3vug: Crystal Structure of a Cysteine-deficient Mutant M2 in Map Kinase Jnk1
376. 3vuh: Crystal Structure of a Cysteine-deficient Mutant M3 in Map Kinase Jnk1
377. 3vui: Crystal Structure of a Cysteine-deficient Mutant M2 in Map Kinase Jnk1
378. 3vuk: Crystal Structure of a Cysteine-deficient Mutant M5 in Map Kinase Jnk1
379. 3vul: Crystal Structure of a Cysteine-deficient Mutant M1 in Map Kinase Jnk1
380. 3vum: Crystal Structure of a Cysteine-deficient Mutant M7 in Map Kinase Jnk1
381. 3w55: The Structure of Erk2 in Complex with Fr148083
382. 4dli: Human P38 Map Kinase in Complex with Rl87
383. 4dlj: Human P38 Map Kinase in Complex with Rl163
384. 4eyj: Mapk13 Complex with Inhibitor
385. 4eym: Mapk13 Complex with Inhibitor
386. 4h3p: Crystal Structure of Human Erk2 Complexed with a Mapk Docking Peptide
387. 4h3q: Crystal Structure of Human Erk2 Complexed with a Mapk Docking Peptide
388. 6hkn: Crystal Structure of Compound 35 with Erk5
389. 6hkm: Crystal Structure of Compound 1 with Erk5
390. 4ic7: Crystal Structure of The Erk5 Kinase Domain in Complex with an Mkk5 Binding Fragment
391. 4ic8: Crystal Structure of The Apo Erk5 Kinase Domain
392. 4iz5: Structure of The Complex between Erk2 Phosphomimetic Mutant and Pea-15
393. 4iz7: Structure of Non-phosphorylated Erk2 Bound to The Pea-15 Death Effector Domain
394. 4iza: Structure of Dually Phosphorylated Erk2 Bound to The Pea-15 Death Effector Domain
395. 3rtp: Design and Synthesis of Brain Penetrant Selective Jnk Inhibitors with Improved Pharmacokinetic Properties for The Prevention of Neurodegeneration
396. 4awi: Human JNK1ALPHA Kinase with 4-phenyl-7-azaindole Ikk2 Inhibitor.
397. 6gjd: Erk2 Signalling Protein
398. 6gjb: Erk2 Signalling Protein
399. 6ges: Crystal Structure of Erk1 Covalently Bound to Sm1-71
400. 6ge0: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
401. 6gdq: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
402. 6gdm: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
403. 6g9n: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
404. 6g9m: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
405. 6g9k: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
406. 6g9j: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
407. 6g9h: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
408. 6g9d: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
409. 6g9a: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
410. 6g97: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
411. 6g93: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
412. 6g92: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
413. 6g91: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
414. 6g8x: Fragment-based Discovery of a Highly Potent, Orally Bioavailable Inhibitor Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
415. 6g54: Crystal Structure of Erk2 Covalently Bound to Sm1-71
416. 4e73: Crystal Structure of JNK1BETA-JIP in Complex with an Azaquinolone Inhbitor
417. 4f9w: Human P38ALPHA Mapk in Complex with a Novel and Selective Small Molecule Inhibitor
418. 6fxv: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
419. 4f9y: Human P38 Alpha Mapk in Complex with a Novel and Selective Small Molecule Inhibitor
420. 4fa2: Human P38 Alpha Mitogen-activated Kinase in Complex with Sb239063
421. 4geo: P38A Map Kinase Def-pocket Penta Mutant (M194A, L195A, H228A, I229A, Y258A)
422. 6frp: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
423. 6fr1: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
424. 6fq7: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
425. 6fn5: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
426. 6fma: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
427. 6flv: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
428. 6fle: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
429. 6fjz: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
430. 6fjb: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
431. 6fj0: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
432. 4kin: Crystal Structure of Mitogen-activated Protein Kinase 14 (p38-h5) Complex with 5-(2-chlorophenyl)-n-(5-(cyclopropylcarbamoyl)-2- Methylphenyl)-2-thiophenecarboxamide
433. 4kip: Crystal Structure of Mitogen-activated Protein Kinase 14 (p38-h5) Complex with 2-(2-chlorophenyl)-n-(5-(cyclopropylcarbamoyl)-2- Methylphenyl)-1,3-thiazole-5-carboxamide
434. 4kiq: Crystal Structure of Mitogen-activated Protein Kinase 14 (p38-h5) Complex with Ethyl 6-((5-(cyclopropylcarbamoyl)-2-methylphenyl) Carbamoyl)-1h-indole-1-carboxylate
435. 6fi6: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
436. 6fi3: Crystal Structure of Erk2 in Complex with an Adenosine Derivative
437. 4ka3: Structure of Map Kinase in Complex with a Docking Peptide
438. 6f5e: Crystal Structure of Darpin-darpin Rigid Fusion, Variant Dd_d12_10_47 in Complex JNK1A1 and Jip1 Peptide
439. 4i5h: Crystal Structure of a Double Mutant Rat Erk2 Complexed with a Type II Quinazoline Inhibitor
440. 6eq9: Crystal Structure of Jnk3 in Complex with Amp-pcp
441. 6emh: Crystal Structure of Jnk3 in Complex with a Pyridinylimidazole Inhibitor
442. 6ekd: Crystal Structure of Jnk3 in Complex with a Pyridinylimidazole Inhibitor
443. 6dtl: Mitogen-activated Protein Kinase 6
444. 6dmg: A Multiconformer Ligand Model of Ek6 Bound to Erk2
445. 6dcg: Discovery of Mk-8353: an Orally Bioavailable Dual Mechanism Erk Inhibitor for Oncology
446. 6d5y: Crystal Structure of Erk2 G169D Mutant
447. 5ra4: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N11337A in Complex with Map Kinase P38-alpha
448. 5ra3: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N10836B in Complex with Map Kinase P38-alpha
449. 5ra2: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N09036B in Complex with Map Kinase P38-alpha
450. 5ra6: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N11338A in Complex with Map Kinase P38-alpha
451. 6cpw: Discovery of 3(s)-thiomethyl Pyrrolidine Erk Inhibitors for Oncology
452. 5ra5: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N11302A in Complex with Map Kinase P38-alpha
453. 5ra9: Pandda Analysis Group Deposition Form1 Map Kinase P38-alpha -- Fragment N08051B in Complex with Map Kinase P38-alpha
454. 4kke: The Crystal Structure of Amp-bound Jnk3
455. 4kkg: Crystal Structure of Apo and Amp-bound Jnk3
456. 4kkh: The Crystal Structure of Inhibitor-bound Jnk3
457. 4l7f: Co-crystal Structure of Jnk1 and Ax13587
458. 4l8m: Human P38 Map Kinase in Complex with a Dibenzoxepinone
459. 4loo: Structural Basis of Autoactivation of P38 Alpha Induced by Tab1 (monoclinic Crystal Form)
460. 4lop: Structural Basis of Autoactivation of P38 Alpha Induced by Tab1 (tetragonal Crystal Form)
461. 4loq: Structural Basis of Autoactivation of P38 Alpha Induced by Tab1 (tetragonal Crystal Form with Bound Sulphate)
462. 4n0s: Complex of Erk2 with Caffeic Acid
463. 4n4s: A Double Mutant Rat Erk2 in Complex with a Pyrazolo[3,4-d]pyrimidine Inhibitor
464. 4nif: Heterodimeric Structure of Erk2 and Rsk1
465. 4o6e: Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine Inhibitors of Erk2
466. 5xyy: The Structure of P38 Alpha in Complex with a Triazol Inhibitor
467. 5xyx: The Structure of P38 Alpha in Complex with a Triazol Inhibitor
468. 5wp1: Complex of Erk2 with 5,7-dihydroxychromone
469. 5wjj: Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based P38 Map Kinase Inhibitors
470. 4qta: Structure of Human Erk2 in Complex with Sch772984 Revealing a Novel Inhibitor-induced Binding Pocket
471. 4qtb: Structure of Human Erk1 in Complex with Sch772984 Revealing a Novel Inhibitor-induced Binding Pocket
472. 4qtd: Structure of Human Jnk1 in Complex with Sch772984 and The Amppnp- Hydrolysed Triphosphate Revealing The Second Type-i Binding Mode
473. 4qte: Structure of Erk2 in Complex with Vtx-11e, 4-{2-[(2-chloro-4- Fluorophenyl)amino]-5-methylpyrimidin-4-yl}-n-[(1s)-1-(3- Chlorophenyl)-2-hydroxyethyl]-1h-pyrrole-2-carboxamide
474. 4qyy: Discovery of Novel, Dual Mechanism Erk Inhibitors by Affinity Selection Screening of an Inactive Kinase State
475. 4u79: Crystal Structure of Human Jnk3 in Complex with a Benzenesulfonamide Inhibitor.
476. 5v62: Phospho-erk2 Bound to Bivalent Inhibitor Sbp3
477. 5v61: Phospho-erk2 Bound to Bivalent Inhibitor Sbp2
478. 5v60: Phospho-erk2 Bound to Amp-pcp
479. 4whz: Design and Synthesis of Highly Potent and Isoform Selective Jnk3 Inhibitors: Sar Studies on Aminopyrazole Derivatives
480. 5uoj: The Structure of The Map Kinase P38 at 2.1 Angstroms Resolution
481. 5umo: Structure of Extracellular Signal-regulated Kinase
482. 4qum: Crystal Structure of Ptpn3 (ptph1) in Complex with a Dually Phosphorylated Mapk12 Peptide
483. 5u6i: Discovery of Mli-2, an Orally Available and Selective Lrrk2 Inhibitor That Reduces Brain Kinase Activity
484. 5tco: Human P38 Map Kinase in Complex with Dibenzosuberone Compound 1
485. 5tbe: Human P38ALPHA Map Kinase in Complex with Dibenzosuberone Compound 2
486. 5omh: P38ALPHA in Complex with Pyrazolobenzothiazine Inhibitor Coxh11
487. 5omg: P38ALPHA in Complex with Pyrazolobenzothiazine Inhibitor COXP4M12
488. 5o90: Crystal Structure of a P38ALPHA T185G Mutant in Complex with Tab1 Peptide.
489. 5o8v: Covalent Inhibitor 4a Bound to The Lipid Pocket of P38ALPHA Mutant S251C
490. 5o8u: Covalent Inhibitor 4b Bound to The Lipid Pocket of P38ALPHA Mutant S252C
491. 5o7i: Erk5 in Complex with a Pyrrole Inhibitor
492. 5nzz: Crystal Structure of Phosphorylated P38AMAPK in Complex with Tab1
493. 5nhv: Human Erk2 with an Erk1/2 Inhibitor
494. 5nhp: Human Erk2 with an Erk1/2 Inhibitor
495. 5nho: Human Erk2 with an Erk1/2 Inhibitor
496. 5nhl: Human Erk2 with an Erk1/2 Inhibitor
497. 5nhj: Human Erk2 with an Erk1/2 Inhibitor
498. 5nhh: Human Erk2 with an Erk1/2 Inhibitor
499. 5nhf: Human Erk2 with an Erk1/2 Inhibitor
500. 5ngu: Human Erk2 with an Erk1/2 Inhibitor
501. 5n68: Crystal Structure of P38ALPHA in Complex with Lipid Pocket Ligand 9m
502. 5n67: Crystal Structure of P38ALPHA in Complex with Lipid Pocket Ligand 9l
503. 5n66: Crystal Structure of P38ALPHA in Complex with Lipid Pocket Ligand 9j
504. 5n65: Crystal Structure of P38ALPHA in Complex with Lipid Pocket Ligand 9h
505. 5n64: Crystal Structure of P38ALPHA in Complex with Lipid Pocket Ligand 9g
506. 5n63: Crystal Structure of P38ALPHA in Complex with Lipid Pocket Ligand 9c
507. 5mz3: P38 Alpha Mutant C162S in Complex with Cmpd2 [n-(4-methyl-3-(4,4,5,5- Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(trifluoromethyl) Benzamide]
508. 5mty: Dibenzosuberone Inhibitor 8e in Complex with P38 Mapk
509. 5mtx: Dibenzooxepinone Inhibitor 12b in Complex with P38 Mapk
510. 5ml5: Human P38ALPHA Mapk in Complex with Imidazolyl Pyridine Inhibitor 11b
511. 5lw1: Crystal Structure of Darpin-darpin Rigid Fusion, Variant Dd_232_11_d12 in Complex JNK1A1 and Jip1 Peptide
512. 5lck: A Clickable Covalent Erk 1/2 Inhibitor
513. 5lcj: In-gel Activity-based Protein Profiling of a Clickable Covalent Erk 1/2 Inhibitor
514. 5lar: Crystal Structure of P38 Alpha Mapk14 in Complex with Vpc00628
515. 5ke0: Discovery of 1-1h-pyrazolo 4,3-c Pyridine-6-yl Urea Inhibitors of Extracellular Signal Regulated Kinase Erk for The Treatment of Cancers
516. 5k4i: Crystal Structure of Erk2 in Complex with Compound 22
517. 5hd7: Dissecting Therapeutic Resistance to Erk Inhibition Rat Mutant Sch772984 in Complex with (3r)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl) Phenyl]piperazin-1-yl}ethyl)-n-[3-(pyridin-4-yl)-2h-indazol-5- Yl]pyrrolidine-3-carboxamide
518. 5hd4: Dissecting Therapeutic Resistance to Erk Inhibition Rat Wild Type Sch772984 in Complex with (3r)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl) Phenyl]piperazin-1-yl}ethyl)-n-[3-(pyridin-4-yl)-2h-indazol-5- Yl]pyrrolidine-3-carboxamide
519. 5eti: Structure of Dead Kinase Mapk14
520. 5etf: Structure of Dead Kinase Mapk14 with Bound The Kim Domain of Mkk6
521. 5etc: Structure of Inactive Mapk14 with Ordered Activation Loop
522. 5eta: Structure of Mapk14 with Bound The Kim Domain of The Toxoplasma Protein Gra24
523. 5eko: Crystal Structure of Mapk13 Complex with Inhibitor
524. 5ekn: Crystal Structure of Mapk13 Complex with Inhibitor
525. 5ci6: Crystal Structure of Arabidopsis Thaliana Mpk6
526. 5byz: Erk5 in Complex with Small Molecule
527. 5byy: Erk5 in Complex with Small Molecule
528. 5bvf: Tetrahydropyrrolo-diazepenones as Inhibitors of Erk2 Kinase
529. 5bve: Tetrahydropyrrolo-diazepenones as Inhibitors of Erk2 Kinase
530. 5bvd: Tetrahydropyrrolo-diazepenones as Inhibitors of Erk2 Kinase
531. 5buj: Erk2 Complexed with a N-h Tetrahydroazaindazole
532. 5bui: Erk2 Complexed with 2-pyridiyl Tetrahydroazaindazole
533. 5bue: Erk2 Complexed with N-benzylpyridone Tetrahydroazaindazole
534. 5ax3: Crystal Structure of Erk2 Complexed with Allosteric and Atp- Competitive Inhibitors.
535. 5awm: The Crystal Structure of Jnk from Drosophila Melanogaster Reveals an Evolutionarily Conserved Topology with That of Mammalian Jnk Proteins.
536. 4w4v: Jnk2/3 in Complex with 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1h- Pyrazol-1-yl)-n-(2-methylpyridin-4-yl)benzamide
537. 4w4w: Jnk2/3 in Complex with N-(2-methylpyridin-4-yl)-3-{4- [(phenylcarbamoyl)amino]-1h-pyrazol-1-yl}benzamide
538. 4w4x: Jnk2/3 in Complex with 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1h- Pyrazol-1-yl)-n-(2-methylpyridin-4-yl)benzamide
539. 4w4y: Jnk2/3 in Complex with 3-(4-{[(4-methylphenyl)carbamoyl]amino}-1h- Pyrazol-1-yl)-n-(2-methylpyridin-4-yl)benzamide
540. 4zxt: Complex of Erk2 with Catechol
541. 4zth: Structure of Human P38AMAPK-ARYLPYRIDAZINYLPYRIDINE Fragment Complex Used in Inhibitor Discovery
542. 4zsl: Mitogen Activated Protein Kinase 7 in Complex with Inhibitor
543. 4zsj: Mitogen Activated Protein Kinase 7 in Complex with Inhibitor
544. 4zsg: Mitogen Activated Protein Kinase 7 in Complex with Inhibitor
545. 4r3c: Crystal Structure of P38 Alpha Map Kinase in Complex with a Novel Isoform Selective Drug Candidate
546. 4myg: Mapk13, Active Form
547. 4ux9: Crystal Structure of Jnk1 Bound to a Mkk7 Docking Motif
548. 4yno: Crystal Structure of Mapk13 at Inactive Form
549. 4yr8: Crystal Structure of Jnk in Complex with a Regulator Protein
550. 4y46: Pyridopyrimidinone Derivatives as Potent and Selective C-jun N- Terminal Kinase (jnk) Inhibitors
551. 4y5h: Pyridopyrimidinone Derivatives as Potent and Selective C-jun N- Terminal Kinase (jnk) Inhibitors
552. 4z9l: The Structure of Jnk3 in Complex with an Imidazole-pyrimidine Inhibitor
553. 4zzm: Human Erk2 in Complex with an Irreversible Inhibitor
554. 4zzn: Human Erk2 in Complex with an Inhibitor
555. 4zzo: Human Erk2 in Complex with an Irreversible Inhibitor
556. 4qp1: Crystal Structure of Erk2 in Complex with N-cyclohexyl-9h-purin-6- Amine
557. 4qp2: Crystal Structure of Erks in Complex with 5-chlorobenzo[d]oxazol-2- Amine
558. 4qp3: Crystal Structure of Erk2 in Complex with (s)-2-((9h-purin-6-yl) Amino)-3-phenylpropan-1-ol
559. 4qp4: Crystal Structure of Erk2 in Complex with N-cyclohexyl-9h-purin-6- Amine
560. 4qp6: Crystal Structure of Erk2 in Complex with 5h-pyrrolo[2,3-b]pyrazine
561. 4qp7: Crystal Structure of Erk2 in Complex with 2-(1h-pyrazol-4-yl)-5h- Pyrrolo[2,3-b]pyrazine
562. 4qp8: Crystal Structure of Erk2 in Complex with 2-(1h-pyrazol-4-yl)-7- (pyridin-3-yl)-5h-pyrrolo[2,3-b]pyrazine
563. 4qp9: Crystal Structure of Erk2 in Complex with 7-(1-propyl-1h-pyrazol-4- Yl)-2-(pyridin-4-yl)-5h-pyrrolo[2,3-b]pyrazine
564. 4qpa: Crystal Structure of Erk2 in Complex with 7-(1-benzyl-1h-pyrazol-4- Yl)-2-(pyridin-4-yl)-5h-pyrrolo[2,3-b]pyrazine
565. 4s2z: Erk2 Intrinsically Active Mutant R65S
566. 4s30: Erk2 Intrinsically Active Mutant (I84A)
567. 4s31: Crystal Structure of Mitogen-activated Protein Kinase 1 Wterk2 at 1.45a
568. 4s32: Crystal Structure of Erk2 Amp-pnp Complex
569. 4s33: Erk2 R65S Mutant Complexed with Amp-pnp
570. 4s34: Erk2 (I84A) in Complex with Amp-pnp
571. 4tyh: Ternary Complex of P38 and Mk2 with a P38 Inhibitor
572. 4x21: The Map Kinase Jnk3 as Target for Halogen Bonding
573. 4xj0: Crystal Structure of Erk2 in Complex with an Inhibitor 14k
574. 4xne: Crystal Structure of Erk2 in Complex with an Inhibitor
575. 4xoy: Crystal Structure of Erk2 in Complex with an Inhibitor
576. 4xoz: Crystal Structure of Erk2 in Complex with an Inhibitor
577. 4xp0: Crystal Structure of Erk2 in Complex with an Inhibitor
578. 4xp2: Crystal Structure of Erk2 in Complex with an Inhibitor
579. 4xp3: Crystal Structure of Erk2 in Complex with an Inhibitor
580. 4xrj: Crystal Structure of Erk2 in Complex with an Inhibitor
581. 4xrl: Crystal Structure at Room Temperature of Erk2 in Complex with an Inhibitor
582. 7bdo: Mapk14 Bound with Sr302
583. 7bdq: Mapk14 Bound with Sr300
584. 7be4: Crystal Structure of Map Kinase P38 Alpha in Complex with Inhibitor Sr159
585. 7be5: Crystal Structure of Map Kinase P38 Alpha in Complex with Inhibitor Sr276
586. 7ksi: Thiophenyl-pyrazolourea Derivatives as Potent, Brian Penetrant, Orally Bioavailable, and Isoform-selective Jnk3 Inhibitors
587. 7ksj: Thiophenyl-pyrazolourea Derivatives as Potent, Brian Penetrant, Orally Bioavailable, and Isoform-selective Jnk3 Inhibitors
588. 7ksk: Thiophenyl-pyrazolourea Derivatives as Potent, Brian Penetrant, Orally Bioavailable, and Isoform-selective Jnk3 Inhibitors
589. 7cga: Crystal Structure of Human Unphosphorylated P38GAMMA
590. 7ore: Crystal Structure of Jnk3 in Complex with Light-activated Covalent Inhibitor Mr-ii-249 with Both Non-covalent and Covalent Binding Modes (compound 4)
591. 7orf: Crystal Structure of Jnk3 in Complex with Fmu-001-367 (compound 1)
592. 7auv: The Structure of Erk2 in Complex with Dual Inhibitor Astx029
593. 7nqq: Discovery of Astx029, a Clinical Candidate Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
594. 7nqw: Discovery of Astx029, a Clinical Candidate Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
595. 7nr3: Discovery of Astx029, a Clinical Candidate Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
596. 7nr5: Discovery of Astx029, a Clinical Candidate Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
597. 7nr8: Discovery of Astx029, a Clinical Candidate Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
598. 7nr9: Discovery of Astx029, a Clinical Candidate Which Modulates The Phosphorylation and Catalytic Activity of Erk1/2
599. 7s1n: N-aromatic-substituted Indazole Derivatives as Brain Penetrant and Orally Bioavailable Jnk3 Inhibitors