EC 2.7.11.26 - ATP:[ tau- protein] O- phosphotransferase ( tau- protein kinase)

3D structures of EC 2.7.11.26 - tau-protein kinase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 3l1s: 3-aryl-4-(arylhydrazono)-1h-pyrazol-5-ones: Highly Ligand Efficient and Potent Inhibitors of Gsk3
2. 3i4b: Crystal Structure of GSK3B in Complex with a Pyrimidylpyrrole Inhibitor
3. 3gb2: GSK3BETA Inhibitor Complex
4. 3f88: Glycogen Synthase Kinase 3beta Inhibitor Complex
5. 3f7z: X-ray Co-crystal Structure of Glycogen Synthase Kinase 3beta in Complex with an Inhibitor
6. 3du8: Crystal Structure of Gsk-3 Beta in Complex with Nms-869553a
7. 3cqw: Crystal Structure of Akt-1 Complexed with Substrate Peptide and Inhibitor
8. 3cqu: Crystal Structure of Akt-1 Complexed with Substrate Peptide and Inhibitor
9. 2xh5: Structure of 4-(4-tert-butylbenzyl)-1-(7h-pyrrolo(2,3-d) Pyrimidin-4-yl)piperidin-4-amine Bound to Pkb
10. 2x39: Structure of 4-amino-n-(4-chlorobenzyl)-1-(7h-pyrrolo(2,3-d) Pyrimidin-4-yl)piperidine-4-carboxamide Bound to Pkb
11. 7b6f: Gsk3-beta in Complex with Compound (s)-5c
12. 2uw9: Structure of Pkb-beta (akt2) Complexed with 4-(4-chloro- Phenyl)-4-(4-(1h-pyrazol-4-yl)-phenyl)-piperidine
13. 2ow3: Glycogen Synthase Kinase-3 Beta in Complex with Bis- (indole)maleimide Pyridinophane Inhibitor
14. 2o5k: Crystal Structure of GSK3BETA in Complex with a Benzoimidazol Inhibitor
15. 6b8j: Co-structure of Human Glycogen Synthase Kinase Beta with a Selective (5-imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino) Ethyl]amine Inhibitor
16. 6ae3: Crystal Structure of GSK3BETA Complexed with Morin
17. 6pxo: Human Casein Kinase 1 Delta (anion-free Crystallization Conditions)
18. 6pxp: Human Casein Kinase 1 Delta Site 2 Mutant (K171E)
19. 2jdo: Structure of Pkb-beta (akt2) Complexed with Isoquinoline-5- Sulfonic Acid (2-(2-(4-chlorobenzyloxy) Ethylamino)ethyl) Amide
20. 2jdr: Structure of Pkb-beta (akt2) Complexed with The Inhibitor A- 443654
21. 2jld: Extremely Tight Binding of Ruthenium Complex to Glycogen Synthase Kinase 3
22. 6tcu: Glycogen Synthase Kinase-3 Beta (GSK3B) in Complex with Ligand 1
23. 3m1s: Structure of Ruthenium Half-sandwich Complex Bound to Glycogen Synthase Kinase 3
24. 3pup: Structure of Glycogen Synthase Kinase 3 Beta (GSK3B) in Complex with a Ruthenium Octasporine Ligand (os1)
25. 6y9s: Crystal Structure of Gsk-3b in Complex with The Imidazo[1,5- A]pyridine-3-carboxamide Inhibitor 16
26. 6y9r: Crystal Structure of Gsk-3b in Complex with The 1h-indazole-3- Carboxamide Inhibitor 2
27. 6ru8: Crystal Structure of Casein Kinase I Delta (CK1D) in Complex with Triple Phosphorylated P63 PAD3P Peptide
28. 6ru7: Crystal Structure of Casein Kinase I Delta (CK1D) in Complex with Double Phosphorylated P63 PAD2P Peptide
29. 6ru6: Crystal Structure of Casein Kinase I Delta (CK1D) in Complex with Monophosphorylated P63 PAD1P Peptide
30. 6rch: Crystal Structure of Casein Kinase I Isoform Delta (ck1 Delta) Complexed with Sr4133 Inhibitor
31. 6rcg: Crystal Structure of Casein Kinase 1 Delta (ck1 Delta) Complexed with Sr3029 Inhibitor
32. 3q3b: 6-amino-4-(pyrimidin-4-yl)pyridones: Novel Glycogen Synthase Kinase-3 Inhibitors
33. 3zrk: Identification of 2-(4-pyridyl)thienopyridinones as Gsk-3beta Inhibitors
34. 3zrl: Identification of 2-(4-pyridyl)thienopyridinones as Gsk-3beta Inhibitors
35. 3zrm: Identification of 2-(4-pyridyl)thienopyridinones as Gsk- 3beta Inhibitors
36. 3sd0: Identification of a Glycogen Synthase Kinase-3b Inhibitor That Attenuates Hyperactivity in Clock Mutant Mice
37. 4dit: Crystal Structure of GSK3BETA in Complex with a Imidazolopyridine Inhibitor
38. 4afj: 5-aryl-4-carboxamide-1,3-oxazoles: Potent and Selective Gsk-3 Inhibitors
39. 4acc: GSK3B in Complex with Inhibitor
40. 4acd: GSK3B in Complex with Inhibitor
41. 4acg: GSK3B in Complex with Inhibitor
42. 4ach: GSK3B in Complex with Inhibitor
43. 4ekk: Akt1 with Amp-pnp
44. 3say: Crystal Structure of Human Glycogen Synthase Kinase 3 Beta (GSK3B) in Complex with Inhibitor 142
45. 4eai: Co-crystal Structure of an Ampk Core with Amp
46. 4eaj: Co-crystal of Ampk Core with Amp Soaked with Atp
47. 4eak: Co-crystal Structure of an Ampk Core with Atp
48. 4eal: Co-crystal of Ampk Core with Atp Soaked with Amp
49. 4hgt: Crystal Structure of CK1D with Compound 13
50. 4hnf: Crystal Structure of CK1D in Complex with Pf4800567
51. 3zdi: Glycogen Synthase Kinase 3 Beta Complexed with Axin Peptide and Inhibitor 7d
52. 4b7t: Glycogen Synthase Kinase 3 Beta Complexed with Axin Peptide and Leucettine L4
53. 6hmr: Crystal Structure of Human Casein Kinase I Delta in Complex with a Photoswitchable 2-azothiazole-based Inhibitor (compound 2)
54. 6hmp: Crystal Structure of Human Casein Kinase I Delta in Complex with a Photoswitchable 2-azoimidazole-based Inhibitor (compound 3)
55. 6hk7: Crystal Structure of Gsk-3b in Complex with Pyrazine Inhibitor C50
56. 6hk4: Crystal Structure of Gsk-3b in Complex with Pyrazine Inhibitor C22
57. 6hk3: Crystal Structure of Gsk-3b in Complex with Pyrazine Inhibitor C44
58. 6pxn: Human Casein Kinase 1 Delta Tau Mutant (R178C)
59. 6h0u: Glycogen Synthase Kinase-3 Beta (gsk3) Complex with a Covalent [1,2, 4]triazolo[1,5-a][1,3,5]triazine Inhibitor
60. 6gzm: Crystal Structure of Human Ckidelta with A86
61. 4j1r: Crystal Structure of GSK3B in Complex with Inhibitor 15r
62. 4j71: Crystal Structure of GSK3B in Complex with Inhibitor 1r
63. 6gn1: Crystal Structure of Glycogen Synthase Kinase-3 Beta (GSK3B) in Complex with Pik-75
64. 6gjo: Crystal Structure of Glycogen Synthase Kinase-3 Beta in Complex with Bi-91bs
65. 4iq6: Gsk-3beta with Inhibitor 6-chloro-n-cyclohexyl-4-(1h-pyrrolo[2,3- B]pyridin-3-yl)pyridin-2-amine
66. 4jjr: A P21 Crystal Form of Mammalian Casein Kinase 1d with a Novel Dimer Interface.
67. 4f2l: Structure of a Regulatory Domain of Ampk
68. 6f26: Crystal Structure of Human Casein Kinase I Delta in Complex with Compound 31b
69. 6f1w: Crystal Structure of Human Casein Kinase I Delta in Complex with Compound 31a
70. 6e4w: Structure of Ampk Bound to Activator
71. 6e4u: Structure of Ampk Bound to Activator
72. 6e4t: Structure of Ampk Bound to Activator
73. 4btj: Ttbk1 in Complex with Atp
74. 4btk: Ttbk1 in Complex with Inhibitor
75. 4btm: Ttbk1 in Complex with Inhibitor
76. 6c9j: Amp-activated Protein Kinase Bound to Pharmacological Activator R734
77. 6c9h: Non-phosphorylated Amp-activated Protein Kinase Bound to Pharmacological Activator R734
78. 6c9g: Amp-activated Protein Kinase Bound to Pharmacological Activator R739
79. 6c9f: Amp-activated Protein Kinase Bound to Pharmacological Activator R734
80. 6c9d: Crystal Structure of Ka1-autoinhibited Mark1 Kinase
81. 4kb8: CK1D in Complex with 1-{4-[3-(4-fluorophenyl)-1-methyl-1h-pyrazol-4- Yl]pyridin-2-yl}-n-methylmethanamine Ligand
82. 4kba: CK1D in Complex with 9-[3-(4-fluorophenyl)-1-methyl-1h-pyrazol-4-yl]- 2,3,4,5-tetrahydropyrido[2,3-f][1,4]oxazepine Inhibitor
83. 4kbc: CK1D in Complex with {4-[3-(4-fluorophenyl)-1h-pyrazol-4-yl]pyridin-2- Yl}methanol Inhibitor
84. 4kbk: CK1D in Complex with (3s)-3-{4-[3-(4-fluorophenyl)-1-methyl-1h- Pyrazol-4-yl]pyridin-2-yl}morpholine Inhibitor
85. 6v6l: Co-structure of Human Glycogen Synthase Kinase Beta with 1-(6-((2-((6- Amino-5-nitropyridin-2-yl)amino)ethyl)amino)-2-(2,4-dichlorophenyl) Pyridin-3-yl)-4-methylpiperazin-2-one
86. 4nm0: Crystal Structure of Peptide Inhibitor-free Gsk-3/axin Complex
87. 4nm3: Crystal Structure of Gsk-3/axin Complex Bound to Phosphorylated N- Terminal Auto-inhibitory Ps9 Peptide
88. 4nm5: Crystal Structure of Gsk-3/axin Complex Bound to Phosphorylated Wnt Receptor Lrp6 C-motif
89. 4nm7: Crystal Structure of Gsk-3/axin Complex Bound to Phosphorylated Wnt Receptor Lrp6 E-motif
90. 4nu1: Crystal Structure of a Transition State Mimic of The Gsk-3/axin Complex Bound to Phosphorylated N-terminal Auto-inhibitory Ps9 Peptide
91. 4qfg: Structure of Ampk in Complex with Staurosporine Inhibitor and in The Absence of a Synthetic Activator
92. 4qfr: Structure of Ampk in Complex with Cl-a769662 Activator and Staurosporine Inhibitor
93. 4qfs: Structure of Ampk in Complex with BR2-A769662CORE Activator and Staurosporine Inhibitor
94. 5x17: Crystal Structure of Murine CK1D in Complex with Adp
95. 5w4w: Identification and Profiling of a Selective and Brain Penetrant Radioligand for in Vivo Target Occupancy Measurement of Casein Kinase 1 (ck1) Inhibitors
96. 4tw9: Difluoro-dioxolo-benzoimidazol-benzamides as Potent Inhibitors of CK1DELTA and Epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation
97. 4twc: 2-benzamido-n-(1h-benzo[d]imidazol-2-yl)thiazole-4- Carboxamide Derivatives as Potent Inhibitors of CK1D/E
98. 5t5t: Ampk Bound to Allosteric Activator
99. 5t31: Exploiting an Asp-glu Switch in Glycogen Synthase Kinase 3 to Design Paralog Selective Inhibitors for Use in Acute Myeloid Leukemia
100. 5oy4: GSK3BETA Complex with N-(6-(3,4-dihydroxyphenyl)-1h-pyrazolo[3,4- B]pyridin-3-yl)acetamide
101. 5okt: Crystal Structure of Human Casein Kinase I Delta in Complex with Iwp-2
102. 5mqv: Crystal Structure of Human Casein Kinase I Delta in Complex with 4-(2, 5-dimethoxyphenyl)-n-(4-(5-(4-fluorphenyl)-2-(methylthio)-1h- Imidazol-4-yl)-pyridin-2-yl)-1-methyl-1h-pyrrole-2-carboxamide
103. 5kz8: Mark2 Complex with 7-[(1s)-1-(4-fluorophenyl)ethyl]-5,5-dimethyl-2-(3- Pyridylamino)pyrrolo[2,3-d]pyrimidin-6-one
104. 5kz7: Mark2 Complex with 7-[(1s)-1-(4-fluorophenyl)ethyl]-5,5-dimethyl-2-(3- Pyridylamino)pyrrolo[2,3-d]pyrimidin-6-one
105. 5kq5: Ampk Bound to Allosteric Activator
106. 5kpm: Glycogen Synthase Kinase 3 Beta Complexed with Brd3731
107. 5kpl: Glycogen Synthase Kinase 3 Beta Complexed with Brd0705
108. 5kpk: Glycogen Synthase Kinase 3 Beta Complexed with Brd0209
109. 5k5n: Crystal Structure of Gsk-3beta Complexed with Pf-04802367, a Highly Selective Brain-penetrant Kinase Inhibitor
110. 5iri: Structure of The Mouse Sad-b Ais-ka1 Fragment
111. 5ih6: Human Casein Kinase 1 Isoform Delta (kinase Domain) in Complex with Epiblastin a Derivative
112. 5ih5: Human Casein Kinase 1 Isoform Delta (kinase Domain) in Complex with Epiblastin a
113. 5ih4: Human Casein Kinase 1 Isoform Delta Apo (kinase Domain)
114. 5hlp: X-ray Crystal Structure of GSK3B in Complex with Brd3937
115. 5hln: X-ray Crystal Structure of GSK3B in Complex with Chir99021
116. 5f95: Crystal Structure of GSK3B in Complex with Compound 18: 2- [(cyclopropylcarbonyl)amino]-n-(4-phenylpyridin-3-yl)pyridine-4- Carboxamide
117. 5f94: Crystal Structure of GSK3B in Complex with Compound 15: 2- [(cyclopropylcarbonyl)amino]-n-(4-methoxypyridin-3-yl)pyridine-4- Carboxamide
118. 5eak: Optimization of Microtubule Affinity Regulating Kinase (mark) Inhibitors with Improved Physical Properties
119. 4red: Crystal Structure of Human Ampk Alpha1 Kd-aid with K43A Mutation
120. 4rer: Crystal Structure of The Phosphorylated Human Alpha1 Beta2 Gamma1 Holo-ampk Complex Bound to Amp and Cyclodextrin
121. 4rew: Crystal Structure of The Non-phosphorylated Human Alpha1 Beta2 Gamma1 Holo-ampk Complex
122. 5air: Structural Analysis of Mouse GSK3BETA Fused with Lrp6 Peptide.
123. 4ptc: Structure of a Carboxamide Compound (3) (2-{2-[(cyclopropylcarbonyl) Amino]pyridin-4-yl}-4-oxo-4h-1lambda~4~,3-thiazole-5-carboxamide) to GSK3B
124. 4pte: Structure of a Carvoxamide Compound (15) (n-[4-(isoquinolin-7-yl) Pyridin-2-yl]cyclopropanecarboxamide) to GSK3B
125. 4ptg: Structure of a Carboxamine Compound (26) (2-{2-[(cyclopropylcarbonyl) Amino]pyridin-4-yl}-4-methoxypyrimidine-5-carboxamide) to GSK3B
126. 4yom: Structure of Sad Kinase
127. 4ynz: Structure of The N-terminal Domain of Sad
128. 4tn6: CK1D in Complex with Inhibitor
129. 7jhg: Cryo-em Structure of Atp-bound Fully Inactive Ampk in Complex with Dorsomorphin (compound C) and Fab-nanobody
130. 7jhh: Cryo-em Structure of Atp-bound Fully Inactive Ampk in Complex with Fab and Nanobody
131. 7jij: Atp-bound Amp-activated Protein Kinase
132. 7m74: Atp-bound Amp-activated Protein Kinase