EC 2.7.11.25 - ATP:protein phosphotransferase (MAPKKKK- activated) (mitogen- activated protein kinase kinase kinase)

3D structures of EC 2.7.11.25 - mitogen-activated protein kinase kinase kinase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 3dtc: Crystal Structure of Mixed-lineage Kinase Mlk1 Complexed with Compound 16
2. 2rf0: Crystal Structure of Human Mixed Lineage Kinase MAP3K10 Sh3 Domain
3. 2clq: Structure of Mitogen-activated Protein Kinase Kinase Kinase 5
4. 2pph: Solution Structure of Human Mekk3 Pb1 Domain
5. 6xih: Structure-guided Optimization of a Novel Class of Ask1 Inhibitors with Increased Sp3 Character and an Exquisite Selectivity Profile
6. 2o2v: Crystal Structure of The Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-PHOX) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-PHOX)
7. 6aqb: Structure of The Sh3 Domain of Mlk3 Bound to Peptide Generated from Phage Display
8. 2npt: Crystal Structure of The Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-PHOX) with Human Mitogen Activated Protein Kinase Kinase Kinase 2 Phox Domain (MAP3K2-PHOX)
9. 6wpp: Human Nik in Complex with Ligand Compound X
10. 2jrh: Solution Sturcture of Human Mekk3 Pb1 Domain Cis Isomer
11. 6whb: Mekk1 Tog Domain (548-867)
12. 6vre: Structure of Ask1 Bound to Bio-1772961
13. 6juu: Crystal Structure of Zak in Complex with Compound 6r
14. 6v0m: Sterile Alpha-motif from Apoptosis Signal-regulating Kinase 3
15. 6oyw: Ask1 Kinase Domain in Complex with Compound 11
16. 6oyt: Ask1 Kinase Domain in Complex with Gs-4997
17. 2yiy: Crystal Structure of Compound 8 Bound to Tak1-tab
18. 6myn: Crystal Structure of Murine Nf-kappab Inducing Kinase (nik) Bound to Inhibitor R7
19. 4dn5: Crystal Structure of Nf-kb-inducing Kinase (nik)
20. 4g3c: Crystal Structure of Apo Murine Nf-kappab Inducing Kinase (nik)
21. 4g3f: Crystal Structure of Murine Nf-kappab Inducing Kinase (nik) Bound to a 2-(aminothiazoly)phenol (cmp2)
22. 4g3g: Crystal Structure of Murine Nf-kappab Inducing Kinase (nik) V408L Bound to a 2-(aminothiazolyl)phenol (cmp3)
23. 4g3d: Crystal Structure of Human Nf-kappab Inducing Kinase (nik)
24. 4g3e: Crystal Structure of Murine Nf-kappab Inducing Kinase (nik) Bound to a 6-alkynylindoline (cmp1)
25. 6jut: Crystal Structure of Zak in Complex with Compound 6k
26. 3vw6: Crystal Structure of Human Apoptosis Signal-regulating Kinase 1 (ask1) with Imidazopyridine Inhibitor
27. 4gs6: Irreversible Inhibition of Tak1 Kinase by 5z-7-oxozeaenol
28. 4idt: Crystal Structure of Nik with 11-bromo-5,6,7,8-tetrahydropyrimido[4', 5':3,4]cyclohepta[1,2-b]indol-2-amine (t28)
29. 4idv: Crystal Structure of Nik with Compound 4-{3-[2-amino-5-(2- Methoxyethoxy)pyrimidin-4-yl]-1h-indol-5-yl}-2-methylbut-3-yn-2-ol (13v)
30. 6g4z: Crystal Structure of Murine Nf-kappab Inducing Kinase (nik) in Complex with Compound 2f
31. 6g4y: Crystal Structure of Murine Nf-kappab Inducing Kinase (nik) in Complex with Compound 1a
32. 4l3p: Crystal Structure of 2-(1-benzothiophen-7-yl)-4-[1-(piperidin-4-yl)- 1h-pyrazol-4-yl]furo[2,3-c]pyridin-7-amine Bound to Tak1-tab1
33. 4bhn: Crystal Structures of Ask1-inhibitor Complexes
34. 4bib: Crystal Structures of Ask1-inhibitor Complexes
35. 4bic: Crystal Structures of Ask1-inhibitor Complexes
36. 4bid: Crystal Structures of Ask1-inhibitor Complexes
37. 4bie: Crystal Structures of Ask1-inhibitor Complexes
38. 4l52: Crystal Structure of 1-(4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl) Furo[2,3-c]pyridin-4-yl]-1h-pyrazol-1-yl}piperidin-1-yl)ethan-1-one Bound to Tak1-tab1
39. 4l53: Crystal Structure of (1r,4r)-4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7- Yl)-3-chlorofuro[2,3-c]pyridin-4-yl]-1h-pyrazol-1-yl}cyclohexan-1-ol Bound to Tak1-tab1
40. 6ejl: Structure of 14-3-3 Zeta in Complex with Ask1 14-3-3 Binding Motif
41. 6e2o: Ask1 Kinase Domain Complex with Inhibitor
42. 6e2n: Ask1 Kinase Domain Complex with Inhibitor
43. 6e2m: Ask1 Kinase Domain Complex with Inhibitor
44. 6cq7: The Sh3 Domain of Mlk3 in Complex with Poly-proline Peptide Derived from Htt
45. 4o91: Crystal Structure of Type II Inhibitor Ng25 Bound to Tak1-tab1
46. 5x5o: Crystal Structure of Zak in Complex with Compound D2829
47. 5vo2: Dlk in Complex with Inhibitor 5-(1-isopropyl-5-(1-(oxetan-3-yl) Piperidin-4-yl)-1h-pyrazol-3-yl)-3-(trifluoromethyl)pyridin-2-amine (compound 7)
48. 5vo1: Dlk in Complex with Compound 10 (5-(1-isopropyl-5-(3-(oxetan-3-yl)-3- Azabicyclo[3.1.0]hexan-6-yl)-1h-pyrazol-3-yl)-3-(trifluoromethyl) Pyridin-2-amine)
49. 5vio: Crystal Structure of Ask1 Kinase Domain with a Potent Inhibitor (analog 13)
50. 5vil: Crystal Structure of Ask1 Kinase Domain with a Potent Inhibitor (analog 6)
51. 5v5n: Crystal Structure of Takinib Bound to Tak1
52. 5v24: Structure-based Drug Design of Novel Ask1 Inhibitors Using a Fully Integrated Lead Optimization Strategy
53. 5v19: Structure-based Drug Design of Novel Ask1 Inhibitors Using a Fully Integrated Lead Optimization Strategy
54. 5up3: Structure-based Design of Ask1 Inhibitors as Potential First-in-class Agents for Heart Failure
55. 5uox: Structure-based Design of Ask1 Inhibitors as Potential First-in-class Agents for Heart Failure
56. 5uor: Structure-based Design of Ask1 Inhibitors as Potential First-in-class Agents for Heart Failure
57. 5ulm: Structure of The Ask1 Central Regulatory Region
58. 5t8q: Crystal Structure of Murine Nf-kappab Inducing Kinase (nik) Bound to Aryl Pyrrole Fragment 17
59. 5t8p: Crystal Structure of Murine Nf-kappab Inducing Kinase (nik) Bound to Benzoxepin Compound 2
60. 5t8o: Crystal Structure of Murine Nf-kappab Inducing Kinase (nik) Bound to Imidazobenzoxepin Compound 3
61. 5k28: Structure of The Unbound Sh3 Domain of Mlk3
62. 5k26: Structure of The Sh3 Domain of Mlk3 Bound to Peptide Generated from Phage Display
63. 5jk3: Crystal Structure of Tl11-128 Bound to Tak1-tab1
64. 5jh6: Crystal Structure of Tl10-92 Bound to Tak1-tab1
65. 5jgd: Crystal Structure of Human Tak1/tab1 Fusion Protein in Complex with Ligand 12
66. 5jgb: Crystal Structure of Human Tak1/tab1 Fusion Protein in Complex with Ligand 10
67. 5jga: Crystal Structure of Human Tak1/tab1 Fusion Protein in Complex with Ligand 11c
68. 5j9l: Crystal Structure of Cpt1691 Bound to Tak1-tab1
69. 5j8i: Crystal Structure of Tl11-113 Bound to Tak1-tab1
70. 5j7s: Crystal Structure of Sm1-71 Bound to Tak1-tab1
71. 5iu2: Discovery of Imidazoquinolines as a Novel Class of Potent, Selective and in Vivo Efficacious Cot Kinase Inhibitors
72. 5hes: Human Leucine Zipper- and Sterile Alpha Motif-containing Kinase (zak, Mlt, Hccs-4, Mrk, Azk, Mltk) in Complex with Vemurafenib
73. 5gjg: Crystal Structure of Human Tak1/tab1 Fusion Protein in Complex with Ligand 4
74. 5gjf: Crystal Structure of Human Tak1/tab1 Fusion Protein in Complex with Ligand 3
75. 5gjd: Crystal Structure of Human Tak1/tab1 Fusion Protein in Complex with Ligand 2
76. 5e7r: Crystal Structure of Tl10-81 Bound to Tak1-tab1
77. 5ceq: Dlk in Complex with Inhibitor 2-((1-cyclopentyl-5-(1-(oxetan-3-yl) Piperidin-4-yl)-1h-pyrazol-3-yl)amino)isonicotinonitrile
78. 5cep: Dlk in Complex with Inhibitor N-(1-isopropyl-5-(piperidin-4-yl)-1h- Pyrazol-3-yl)-4-(trifluoromethyl)pyridin-2-amine
79. 5ceo: Dlk in Complex with Inhibitor 2-((6-(3,3-difluoropyrrolidin-1-yl)-4- (1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile
80. 5cen: Crystal Structure of Dlk (kinase Domain)
81. 4y83: Crystal Structure of Cot Kinase Domain in Complex with 5-(2-amino-5- (quinolin-3-yl)pyridin-3-yl)-1,3,4-oxadiazole-2(3h)-thione
82. 4y85: Crystal Structure of Cot Kinase Domain in Complex with 5-(5-(1h-indol- 3-yl)-1h-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine
83. 4uy9: Structure of Mlk1 Kinase Domain with Leucine Zipper 1
84. 4uya: Structure of Mlk4 Kinase Domain with Atpgammas
85. 4y5o: Ccm2 Hhd in Complex with Mekk3 Npb1
86. 7nth: Structure of Tak1 in Complex with Compound 54
87. 7nti: Structure of Tak1 in Complex with Compound 22