EC 2.7.11.30 - ATP:[receptor- protein] phosphotransferase (receptor protein serine/threonine kinase)

3D structures of EC 2.7.11.30 - receptor protein serine/threonine kinase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 3oom: Crystal Structure of The Acvr1 Kinase Domain in Complex with The Imidazo[1,2-b]pyridazine Inhibitor K00507
2. 3nh7: Crystal Structure of The Neutralizing Fab Fragment Abd1556 Bound to The Bmp Type I Receptor Ia
3. 3my0: Crystal Structure of The Acvrl1 (alk1) Kinase Domain Bound to Ldn- 193189
4. 3mtf: Crystal Structure of The Acvr1 Kinase in Complex with a 2- Aminopyridine Inhibitor
5. 3mdy: Crystal Structure of The Cytoplasmic Domain of The Bone Morphogenetic Protein Receptor Type-1b (BMPR1B) in Complex with Fkbp12 and Ldn- 193189
6. 3kcf: Crystal Structure of Tgfbri Complexed with a Pyrazolone Inhibitor
7. 3hmm: Structure of Alk5 + Gw855857
8. 3h9r: Crystal Structure of The Kinase Domain of Type I Activin Receptor (acvr1) in Complex with Fkbp12 and Dorsomorphin
9. 3gxl: Alk-5 Kinase Complex with Gw857175
10. 3g2f: Crystal Structure of The Kinase Domain of Bone Morphogenetic Protein Receptor Type II (bmpr2) at 2.35 a Resolution
11. 3faa: Crystal Structure of Tgfbri Complexed with a 2- Aminoimidazole Inhibitor
12. 2x7o: Crystal Structure of Tgfbri Complexed with an Indolinone Inhibitor
13. 2wou: Alk5 in Complex with 4-((4-((2,6-dimethyl-3-pyridyl)oxy)-2- Pyridyl)amino)benzenesulfonamide
14. 2wot: Alk5 in Complex with 4-((5,6-dimethyl-2-(2-pyridyl)-3- Pyridyl)oxy)-n-(3,4,5-trimethoxyphenyl)pyridin-2-amine
15. 7a21: Crystal Structure of The Acvr1 (alk2) Kinase in Complex with The Compound M4K2158
16. 6zgc: Crystal Structure of The Acvr1 (alk2) Kinase in Complex with The Compound Saracatinib (azd0530)
17. 2qlu: Crystal Structure of Activin Receptor Type II Kinase Domain from Human
18. 2pjy: Structural Basis for Cooperative Assembly of The Tgf-beta Signaling Complex
19. 6b8y: Tgf-beta Receptor Type 1 Kinase Domain (T204D) in Complex with N-(3- Fluoropyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-2-yl]-7h-pyrrolo[2, 3-d]pyrimidin-4-amine
20. 6acr: Crystal Structure of Human Alk2 Kinase Domain with R206H Mutation in Complex with Rk-59638
21. 2goo: Ternary Complex of Bmp-2 Bound to Bmpr-ia-ecd and Actrii-ecd
22. 2h62: Crystal Structure of a Ternary Ligand-receptor Complex of Bmp-2
23. 2h64: Crystal Structure of a Ternary Ligand-receptor Complex of Bmp-2
24. 6tn8: Crystal Structure of The Acvr1 (alk2) Kinase in Complex with The Compound Bi-9564
25. 2hlq: Crystal Structure of The Extracellular Domain of The Type II Bmp Receptor
26. 2hlr: Crystal Structure of The Extracellular Domain of The Type II Bmp Receptor
27. 2k3g: Nmr Structure Analysis of a Bmp Receptor
28. 6z36: Crystal Structure of The Acvr1 (alk2) Kinase in Complex with The Compound M4K2118
29. 3q4t: Crystal Structure of Activin Receptor Type-iia (ACVR2A) Kinase Domain in Complex with Dorsomorphin
30. 3q4u: Crystal Structure of The Acvr1 Kinase Domain in Complex with Ldn- 193189
31. 6jux: Crystal Structure of Human Alk2 Kinase Domain with R206H Mutation in Complex with Rk-71807
32. 6sf3: Bone Morphogenetic Protein 10 (bmp10) in Complex with Extracellular Domain of Activin Receptor-like Kinase 1 (alk1) at 2.3 Angstrom
33. 6sf2: Ternary Complex of Human Bone Morphogenetic Protein 9 (bmp9) Growth Factor Domain, Its Prodomain and Extracellular Domain of Activin Receptor-like Kinase 1 (alk1).
34. 6sf1: Bone Morphogenetic Protein 10 (bmp10) Complexed with Extracellular Domain of Activin Receptor-like Kinase 1 (alk1).
35. 3soc: Crystal Structure of Activin Receptor Type-iia (ACVR2A) Kinase Domain in Complex with a Quinazolin
36. 6t8n: Crystal Structure of The Acvr1 (alk2) Kinase in Complex with The Compound M4K3007
37. 6t6d: Crystal Structure of The Acvr1 (alk2) Kinase in Complex with The Compound M4K2149
38. 6szm: Crystal Structure of The Acvr1 (alk2) Kinase in Complex with The Compound M4K2009
39. 6srh: Crystal Structure of The Acvr1 (alk2) Kinase in Complex with The Compound M4K2117
40. 2l5s: Solution Structure of The Extracellular Domain of The Tgf-beta Type I Receptor
41. 3qb4: Crystal Structure of a Tgf-beta Ligand-receptor Complex
42. 4dym: Crystal Structure of The Acvr1 Kinase Domain in Complex with The Imidazo[1,2-b]pyridazine Inhibitor K00135
43. 3tzm: Tgf-beta Receptor Type 1 in Complex with Sb431542
44. 4asx: Crystal Structure of Activin Receptor Type-iia (ACVR2A) Kinase Domain in Complex with Dihydro-bauerine C
45. 2lcr: Nmr Structure of Alk1 Extracellular Domain
46. 6mac: Ternary Structure of Gdf11 Bound to Actriib-ecd and Alk5-ecd
47. 6i1s: Crystal Structure of The Acvr1 (alk2) Kinase in Complex with Fkbp12 and The Inhibitor E6201
48. 4bgg: Crystal Structure of The Acvr1 Kinase in Complex with Ldn-213844
49. 6gip: Crystal Structure of The Acvr1 (alk2) Kinase in Complex with a Quinazolinone Based Alk2 Inhibitor with a 2, 5-dimethyl Core.
50. 6gin: Crystal Structure of The Acvr1 (alk2) Kinase in Complex with an Quinazolinone Based Alk2 Inhibitor with a 4-morpholinophenyl Solvent Accessible Group.
51. 6gi6: Crystal Structure of The Acvr1 (alk2) Kinase in Complex with a Quinazolinone Based Alk2 Inhibitor with a 5-methyl Core.
52. 6eix: Crystal Structure of The Kinase Domain of The Q207E Mutant of Acvr1 (alk2) in Complex with a 2-aminopyridine Inhibitor K02288
53. 4c02: Crystal Structure of Human Acvr1 (alk2) in Complex with Fkbp12.6 and Dorsomorphin
54. 5qtz: Tgf-beta Receptor Type 1 Kinase Domain (T204D) in Complex with 6-[1- (2,2-difluoroethyl)-4-(6-methylpyridin-2-yl)-1h-imidazol-5- Yl]imidazo[1,2-a]pyridine
55. 5qu0: Tgf-beta Receptor Type 1 Kinase Domain (T204D) in Complex with 6-[4- (3-chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-1h-imidazol-5- Yl]imidazo[1,2-b]pyridazine-3-carbonitrile
56. 5usq: Alk-5 Kinase Inhibitor Complex
57. 5ty4: Microed Structure of a Complex between Monomeric Tgf-b and Its Receptor, Tbrii, at 2.9 a Resolution
58. 5tx4: Derivative of Mouse Tgf-beta2, with a Deletion of Residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V Single Amino Acid Substitutions, Bound to Human Tgf-beta Type II Receptor Ectodomain Residues 15-130
59. 5qin: Tgf-beta Receptor Type 2 Kinase Domain in Complex with N- {4-[3-(6- Methoxypyridin-3-yl)-1h-pyrrolo[3,2-b]pyridin-2- Yl]pyridin-2- Yl}acetamide
60. 5qim: Tgf-beta Receptor Type 1 Kinase Domain (T204D) in Complex with N-{4- [3-(5-methoxypyridin-2-yl)-1h-pyrrolo[3,2-b] Pyridin-2-yl]pyridin-2- Yl}acetamide
61. 5qil: Tgf-beta Receptor Type 1 Kinase Domain (T204D) in Complex with N-{4- [3-(6-methoxypyridin-3-yl)-1h-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2- Yl}acetamide
62. 5qik: Tgf-beta Receptor Type 1 Kinase Domain (T204D) in Complex with N-{4- [3-(6-fluoropyridin-3-yl)-4-oxo-4,5,6,7-tetrahydro-1h-pyrrolo[3,2- C]pyridin-2-yl]pyridin-2-yl}acetamide
63. 5oy6: Crystal Structure of The Acvr1 (alk2) Kinase in Complex with Cyclical Inhibitor Od36.
64. 5oxg: Crystal Structure of The Acvr1 (alk2) Kinase in Complex with Ldn- 212854
65. 5nhr: Crystal Structure of The Activin Receptor Type-2b Ligand Binding Domain in Complex with Bimagrumab Fv, Cubic Crystal Form
66. 5nh3: Crystal Structure of The Activin Receptor Type-2a Ligand Binding Domain in Complex with Bimagrumab Fv
67. 5ngv: Crystal Structure of The Activin Receptor Type-2b Ligand Binding Domain in Complex with Bimagrumab Fv, Orthorhombic Crystal Form
68. 5fri: Alk5 in Complex Witha an N-(4-anilino-2-pyridyl)acetamide Inhibitor.
69. 5e92: Tgf-beta Receptor Type 2 Kinase Domain (E431A,R433A,E485A,K488A,R493A, R495A) in Complex with Amppnp
70. 5e91: Tgf-beta Receptor Type 2 Kinase Domain (E431A,R433A,E485A,K488A,R493A, R495A) in Complex with 3-amino-6-[4-(2- Hydroxyethyl)phenyl]-n-[4- (morpholin-4-yl)pyridin-3-yl] Pyrazine-2-carboxamide
71. 5e90: Tgf-beta Receptor Type 1 Kinase Domain (T204D,I211V,Y249F, S280T, Y282F,S287N,A350C,L352F) in Complex with 3-amino-6- [4-(2- Hydroxyethyl)phenyl]-n-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2- Carboxamide
72. 5e8z: Tgf-beta Receptor Type 1 Kinase Domain (T204D) in Complex with 3- Amino-6-[4-(2-hydroxyethyl)phenyl]-n-[4-(morpholin-4-yl)pyridin-3- Yl]pyrazine-2-carboxamide
73. 5e8y: Tgf-beta Receptor Type 2 Kinase Domain (E431A,R433A,E485A,K488A,R493A, R495A) in Complex with Staurosporine
74. 5e8x: Tgf-beta Receptor Type 1 Kinase Domain (T204D,I211V,Y249F,S280T, Y282F,S287N,A350C,L352F) in Complex with Staurosporine
75. 5e8w: Tgf-beta Receptor Type 1 Kinase Domain (T204D) in Complex with Staurosporine
76. 5e8v: Tgf-beta Receptor Type 2 Kinase Domain (E431A,R433A,E485A,K488A,R493A, R495A)
77. 5e8u: Tgf-beta Receptor Type 1 Kinase Domain (T204D,I211V,Y249F,S280T, Y282F,S287N,A350C,L352F)
78. 5e8t: Tgf-beta Receptor Type 1 Kinase Domain (T204D)
79. 5e8s: Tgf-beta Receptor Type 1 Kinase Domain (wt)
80. 4x0m: Selection of Fragments for Kinase Inhibitor Design: Decoration Is Key
81. 4x2j: Selection of Fragments for Kinase Inhibitor Design: Decoration Is Key
82. 4x2k: Selection of Fragments for Kinase Inhibitor Design: Decoration Is Key
83. 4x2n: Selection of Fragments for Kinase Inhibitor Design: Decoration Is Key
84. 4p7u: Extracellular Domain of Type II Transforming Growth Factor Beta Receptor in Complex with Ndsb-201
85. 4x2f: Selection of Fragments for Kinase Inhibitor Design: Decoration Is Key
86. 4x2g: Selection of Fragments for Kinase Inhibitor Design: Decoration Is Key
87. 4xjj: Extracellular Domain of Type II Transforming Growth Factor Beta Receptor in Complex with 2-(2-hydroxyethyl)ndsb-201
88. 5s75: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010913A
89. 7c3g: Crystal Structure of Human Alk2 Kinase Domain with R206H Mutation in Complex with a Bicyclic Pyrazole Inhibitor Rk-73134
90. 7nns: Crystal Structure of The Acvr1 (alk2) Kinase in Complex with The Compound Momelotinib
91. 7dv6: Discovery of Functionally Selective Transforming Growth Factor Beta Type II Receptor (tgf-beta Rii) Inhibitors as Anti-fibrosis Agents
92. 5s76: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010916A
93. 5s77: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with XS035133B
94. 5s78: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010934A
95. 5s79: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010910A
96. 5s7a: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with PK012456B
97. 5s7b: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM000329D
98. 5s7c: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM000274C
99. 5s7d: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010923A
100. 5s7e: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010930A
101. 5s7f: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010935A
102. 5s7g: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with XS035844B
103. 5s7h: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010914A
104. 5s7i: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010928A
105. 5s7j: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM000893D
106. 5s7k: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010936A
107. 5s7l: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010943A
108. 5s7m: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM000275D
109. 5s7n: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010920A
110. 5s7o: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM007391C
111. 5s7p: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010937A
112. 5s7q: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010944A
113. 5s7r: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010918A
114. 5s7s: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010921A
115. 5s7t: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010926A
116. 5s7u: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010938A
117. 5s7v: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010942A
118. 5s7w: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with HM000007H
119. 5s7x: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM000376D
120. 5s7y: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010933A
121. 5s7z: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with NU074488B
122. 5s80: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010946A
123. 5s81: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010947A
124. 5s82: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with XS035128C
125. 5s83: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010948A
126. 5s84: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010949A
127. 5s85: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM000884C
128. 5s86: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010952A
129. 5s87: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010953A
130. 5s88: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010954A
131. 5s89: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010957A
132. 5s8a: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with NU074484B
133. 5s8b: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010960A
134. 5s9k: Xchem Group Deposition -- Crystal Structure of Human Acvr1 in Complex with FM010955A
135. 7l0j: Structure of Amh Bound to Amhr2-ecd
136. 6unp: Crystal Structure of The Kinase Domain of BMPR2-D485G
137. 6unq: Kinase Domain of ALK2-K493A with Amppnp
138. 6unr: Kinase Domain of ALK2-K492A/K493A with Amppnp
139. 6uns: Kinase Domain of ALK2-K492A/K493A with Ldn-193189