EC 2.7.11.22 - ATP:cyclin phosphotransferase (cyclin- dependent kinase)

3D structures of EC 2.7.11.22 - cyclin-dependent kinase in Protein Data Bank

updated: 6 January 2022, 2:15

1. 1fq1: Crystal Structure of Kinase Associated Phosphatase (kap) in Complex with Phospho-cdk2
2. 1h01: Cdk2 in Complex with a Disubstituted 2, 4-bis Anilino Pyrimidine Cdk4 Inhibitor
3. 3my5: Cdk2/cyclina in Complex with Drb
4. 3my1: Structure of Cdk9/cyclint1 in Complex with Drb
5. 3mtl: Crystal Structure of The Pctaire1 Kinase in Complex with Indirubin E804
6. 3mia: Crystal Structure of Hiv-1 Tat Complexed with Atp-bound Human P-tefb
7. 3mi9: Crystal Structure of Hiv-1 Tat Complexed with Human P-tefb
8. 3lfs: Crystal Structure of Cdk2 with Sar37, an Aminoindazole Type Inhibitor
9. 3lfq: Crystal Structure of Cdk2 with Sar60, an Aminoindazole Type Inhibitor
10. 3lfn: Crystal Structure of Cdk2 with Sar57, an Aminoindazole Type Inhibitor
11. 3le6: The Structure of Cyclin Dependent Kinase 2 (ckd2) with a Pyrazolobenzodiazepine Inhibitor
12. 3igg: Novel Cdk-5 Inhibitors - Crystal Structure of Inhibitor Efq with Cdk-2
13. 3ig7: Novel Cdk-5 Inhibitors - Crystal Structure of Inhibitor Efp with Cdk-2
14. 3gbz: Structure of The Cmgc Cdk Kinase from Giardia Lamblia
15. 3g33: Crystal Structure of Cdk4/cyclin D3
16. 3fz1: Crystal Structure of a Benzthiophene Inhibitor Bound to Human Cyclin-dependent Kinase-2 (cdk-2)
17. 3f5x: Cdk-2-cyclin Complex with Indazole Inhibitor 9 Bound at Its Active Site
18. 3ezv: Cdk-2 with Indazole Inhibitor 9 Bound at Its Active Site
19. 3ezr: Cdk-2 with Indazole Inhibitor 17 Bound at Its Active Site
20. 3eoc: Cdk2/cyclina Complexed with a Imidazo Triazin-2-amine
21. 3ej1: Cdk2/cyclina Complexed with a Pyrazolopyridazine Inhibitor
22. 3eid: Cdk2/cyclina Complexed with a Pyrazolopyridazine Inhibitor
23. 3dog: Structure of Thr 160 Phosphorylated Cdk2/cyclin a in Complex with The Inhibitor N-&-n1
24. 6jgm: Crystal Structure of Cdk2 in Complex with Inhibitor Nu-6140
25. 3ddq: Structure of Phosphorylated Thr160 Cdk2/cyclin a in Complex with The Inhibitor Roscovitine
26. 3ddp: Structure of Phosphorylated Thr160 Cdk2/cyclin a in Complex with The Inhibitor Cr8
27. 1ung: Structural Mechanism for The Inhibition of Cdk5-p25 by Roscovitine, Aloisine and Indirubin.
28. 1unh: Structural Mechanism for The Inhibition of Cdk5-p25 by Roscovitine, Aloisine and Indirubin.
29. 1urc: Cyclin a Binding Groove Inhibitor Ace-arg-lys-leu- Phe-gly
30. 3blr: Crystal Structure of Human Cdk9/cyclint1 in Complex with Flavopiridol
31. 3blq: Crystal Structure of Human Cdk9/cyclint1 in Complex with Atp
32. 3blh: Crystal Structure of Human Cdk9/cyclint1
33. 3bhv: Structure of Phosphorylated Thr160 Cdk2/cyclin a in Complex with The Inhibitor Variolin B
34. 3bhu: Structure of Phosphorylated Thr160 Cdk2/cyclin a in Complex with The Inhibitor Meriolin 5
35. 3bht: Structure of Phosphorylated Thr160 Cdk2/cyclin a in Complex with The Inhibitor Meriolin 3
36. 2xnb: Discovery and Characterisation of 2-anilino-4-(thiazol-5-yl) Pyrimidine Transcriptional Cdk Inhibitors as Anticancer Agents
37. 2xmy: Discovery and Characterisation of 2-anilino-4-(thiazol-5-yl) Pyrimidine Transcriptional Cdk Inhibitors as Anticancer Agents
38. 2wmb: Structural and Thermodynamic Consequences of Cyclization of Peptide Ligands for The Recruitment Site of Cyclin a
39. 2wma: Structural and Thermodynamic Consequences of Cyclization of Peptide Ligands for The Recruitment Site of Cyclin a
40. 2w9z: Crystal Structure of Cdk4 in Complex with a D-type Cyclin
41. 2w9f: Crystal Structure of Cdk4 in Complex with a D-type Cyclin
42. 2w99: Crystal Structure of Cdk4 in Complex with a D-type Cyclin
43. 2w96: Crystal Structure of Cdk4 in Complex with a D-type Cyclin
44. 2w17: Cdk2 in Complex with The Imidazole Pyrimidine Amide, Compound (s)-8b
45. 2w06: Structure of Cdk2 in Complex with an Imidazolyl Pyrimidine, Compound 5c
46. 2w05: Structure of Cdk2 in Complex with an Imidazolyl Pyrimidine, Compound 5b
47. 2vv9: Cdk2 in Complex with an Imidazole Piperazine
48. 2vu3: Identification of N-(4-piperidinyl)-4-(2,6- Dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment- Based X-ray Crystallography and Structure Based Drug Design.
49. 2vtt: Identification of N-(4-piperidinyl)-4-(2,6- Dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment- Based X-ray Crystallography and Structure Based Drug Design.
50. 2vts: Identification of N-(4-piperidinyl)-4-(2,6- Dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment- Based X-ray Crystallography and Structure Based Drug Design.
51. 2vtr: Identification of N-(4-piperidinyl)-4-(2,6- Dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment- Based X-ray Crystallography and Structure Based Drug Design.
52. 2vtq: Identification of N-(4-piperidinyl)-4-(2,6- Dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment- Based X-ray Crystallography and Structure Based Drug Design.
53. 2vtp: Identification of N-(4-piperidinyl)-4-(2,6- Dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment- Based X-ray Crystallography and Structure Based Drug Design.
54. 2vto: Identification of N-(4-piperidinyl)-4-(2,6- Dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment- Based X-ray Crystallography and Structure Based Drug Design.
55. 2vtn: Identification of N-(4-piperidinyl)-4-(2,6- Dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment- Based X-ray Crystallography and Structure Based Drug Design.
56. 2vtm: Identification of N-(4-piperidinyl)-4-(2,6- Dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment- Based X-ray Crystallography and Structure Based Drug Design.
57. 2vtl: Identification of N-(4-piperidinyl)-4-(2,6- Dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment- Based X-ray Crystallography and Structure Based Drug Design.
58. 2vtj: Identification of N-(4-piperidinyl)-4-(2,6- Dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment- Based X-ray Crystallography and Structure Based Drug Design.
59. 2vti: Identification of N-(4-piperidinyl)-4-(2,6- Dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment- Based X-ray Crystallography and Structure Based Drug Design.
60. 2vth: Identification of N-(4-piperidinyl)-4-(2,6- Dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment- Based X-ray Crystallography and Structure Based Drug Design
61. 2vta: Identification of N-(4-piperidinyl)-4-(2,6- Dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment- Based X-ray Crystallography and Structure Based Drug Design.
62. 6z45: Cdk9-cyclin-t1 Complex Bound by Compound 24
63. 2v0d: Crystal Structure of Human Cdk2 Complexed with a Thiazolidinone Inhibitor
64. 2uzo: Crystal Structure of Human Cdk2 Complexed with a Thiazolidinone Inhibitor
65. 2uzn: Crystal Structure of Human Cdk2 Complexed with a Thiazolidinone Inhibitor
66. 2uzl: Crystal Structure of Human Cdk2 Complexed with a Thiazolidinone Inhibitor
67. 2uze: Crystal Structure of Human Cdk2 Complexed with a Thiazolidinone Inhibitor
68. 2uzd: Crystal Structure of Human Cdk2 Complexed with a Thiazolidinone Inhibitor
69. 2uzb: Crystal Structure of Human Cdk2 Complexed with a Thiazolidinone Inhibitor
70. 2r64: Crystal Structure of a 3-aminoindazole Compound with Cdk2
71. 2r3r: Crystal Structure of Cyclin-dependent Kinase 2 with Inhibitor
72. 2r3q: Crystal Structure of Cyclin-dependent Kinase 2 with Inhibitor
73. 2r3p: Crystal Structure of Cyclin-dependent Kinase 2 with Inhibitor
74. 2r3o: Crystal Structure of Cyclin-dependent Kinase 2 with Inhibitor
75. 2r3n: Crystal Structure of Cyclin-dependent Kinase 2 with Inhibitor
76. 2r3m: Crystal Structure of Cyclin-dependent Kinase 2 with Inhibitor
77. 2r3l: Crystal Structure of Cyclin-dependent Kinase 2 with Inhibitor
78. 2r3k: Crystal Structure of Cyclin-dependent Kinase 2 with Inhibitor
79. 2r3j: Crystal Structure of Cyclin-dependent Kinase 2 with Inhibitor
80. 2r3i: Crystal Structure of Cyclin-dependent Kinase 2 with Inhibitor
81. 2r3h: Crystal Structure of Cyclin-dependent Kinase 2 with Inhibitor
82. 2r3g: Crystal Structure of Cyclin-dependent Kinase 2 with Inhibitor
83. 2r3f: Crystal Structure of Cyclin-dependent Kinase 2 with Inhibitor
84. 2qkr: Cryptosporidium Parvum Cyclin-dependent Kinase Cgd5_2510 with Indirubin 3'-monoxime Bound
85. 2cci: Crystal Structure of Phospho-cdk2 Cyclin a in Complex with a Peptide Containing Both The Substrate and Recruitment Sites of Cdc6
86. 2clx: 4-arylazo-3,5-diamino-1h-pyrazole Cdk Inhibitors: Sar Study, Crystal Structure in Complex with Cdk2, Selectivity, and Cellular Effects
87. 2pmi: Structure of The Pho85-pho80 Cdk-cyclin Complex of The Phosphate-responsive Signal Transduction Pathway with Bound Atp-gamma-s
88. 2pk9: Structure of The Pho85-pho80 Cdk-cyclin Complex of The Phosphate-responsive Signal Transduction Pathway
89. 6ylk: CDK2(F80C) with Covalent Adduct Tk22 at F80C
90. 6yl6: CDK2(F80C)
91. 6yl1: CDK2(F80C) with Covalent Adduct Tk37 at F80C
92. 2ds1: Human Cyclin Dependent Kinase 2 Complexed with The Cdk4 Inhibitor
93. 2duv: Structure of Cdk2 with a 3-hydroxychromones
94. 6b3e: Crystal Structure of Human Cdk12/cyclink in Complex with an Inhibitor
95. 6ath: Cdk2/cyclin A/p27-kid-deltac
96. 6t41: Cdk8/cyclin C in Complex with N-(4-chlorobenzyl)isoquinolin-4-amine
97. 2i40: Cdk2/cyclin a Complexed with a Thiophene Carboxamide Inhibitor
98. 6xd3: Structure of The Human Cak in Complex with Thz1
99. 6xbz: Structure of The Human Cdk-activating Kinase
100. 6tpa: Cdk8/cyclinc in Complex with Drug Etp-50775
101. 6rij: Cdk2/cyclin A2 in Complex with Open-ring 5-nitrosopyrimidine Inhibitor Lc436
102. 6oqo: Cdk6 in Complex with Cpd24 N-(5-(6-ethyl-2,6-diazaspiro[3.3]heptan-2- Yl)pyridin-2-yl)-5-fluoro-4-(4-methyl-5,6,7,8-tetrahydro-4h- Pyrazolo[1,5-a]azepin-3-yl)pyrimidin-2-amine
103. 6oql: Cdk6 in Complex with Cpd13 (r)-5-fluoro-4-(4-methyl-5,6,7,8- Tetrahydro-4h-pyrazolo[1,5-a]azepin-3-yl)-n-(5-(4-methylpiperazin-1- Yl)pyridin-2-yl)pyrimidin-2-amine
104. 6oqi: Cdk2 in Complex with Cpd14 (5-fluoro-4-(4-methyl-5,6,7,8-tetrahydro- 4h-pyrazolo[1,5-a]azepin-3-yl)-n-(5-(4-methylpiperazin-1-yl)pyridin- 2-yl)pyrimidin-2-amine)
105. 3ns9: Crystal Structure of Cdk2 in Complex with Inhibitor Bs-194
106. 6td3: Structure of Ddb1 Bound to Cr8-engaged Cdk12-cyclink
107. 3lq5: Structure of Cdk9/cyclint in Complex with S-cr8
108. 3nup: Cdk6 (monomeric) in Complex with Inhibitor
109. 3nux: Cdk6 (monomeric) in Complex with Inhibitor
110. 3o0g: Crystal Structure of Cdk5:p25 in Complex with an Atp Analogue
111. 3pxf: Cdk2 in Complex with Two Molecules of 8-anilino-1-naphthalene Sulfonate
112. 3pxq: Cdk2 in Complex with 3 Molecules of 8-anilino-1-naphthalene Sulfonate
113. 3pxr: Apo Cdk2 Crystallized from Jeffamine
114. 3pxy: Cdk2 in Complex with Inhibitor Jws648
115. 3pxz: Cdk2 Ternary Complex with Jws648 and Ans
116. 3py0: Cdk2 in Complex with Inhibitor Su9516
117. 3py1: Cdk2 Ternary Complex with Su9516 and Ans
118. 3pj8: Structure of Cdk2 in Complex with a Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine.
119. 3qhr: Structure of a Pcdk2/cyclina Transition-state Mimic
120. 3qhw: Structure of a Pcdk2/cyclina Transition-state Mimic
121. 6r3s: Crystal Structure of Cdk8-cycc in Complex with Compound 1
122. 6qtj: Crystal Structure of Human Cdk8/cycc in Complex with Bi 919811
123. 6qtg: Crystal Structure of Human Cdk8/cycc in Complex with Bi-1347
124. 3s2p: Crystal Structure of Cdk2 with a 2-aminopyrimidine Compound
125. 3rgf: Crystal Structure of Human Cdk8/cycc
126. 6p8h: Crystal Structure of Cdk4 in Complex with Cyclind1 and P21
127. 6p8g: Crystal Structure of Cdk4 in Complex with Cyclind1 and P27
128. 6p8f: Crystal Structure of Cdk4 in Complex with Cyclind1 and P27
129. 6p8e: Crystal Structure of Cdk4 in Complex with Cyclind1 and P27
130. 4aaa: Crystal Structure of The Human Cdkl2 Kinase Domain
131. 6q4k: Cdk2 in Complex with Fraglite38
132. 6q4j: Cdk2 in Complex with Fraglite34
133. 6q4i: Cdk2 in Complex with Fraglite35
134. 6q4h: Cdk2 in Complex with Fraglite36
135. 6q4g: Cdk2 in Complex with Fraglite37
136. 6q4f: Cdk2 in Complex with Fraglite32
137. 6q4e: Cdk2 in Complex with Fraglite33
138. 6q4d: Cdk2 in Complex with Fraglite31
139. 6q4c: Cdk2 in Complex with Fraglite16
140. 6q4b: Cdk2 in Complex with Fraglite13
141. 6q49: Cdk2 in Complex with Fraglite6
142. 6q48: Cdk2 in Complex with Fraglite7
143. 6q3f: Cdk2 in Complex with Fraglite2
144. 6q3c: Cdk2 in Complex with Fraglite1
145. 6q3b: Cdk2 in Complex with Fraglite2
146. 3unj: Cdk2 in Complex with Inhibitor Yl1-038-31
147. 3unk: Cdk2 in Complex with Inhibitor Yl5-083
148. 3tn8: Cdk9/cyclin T in Complex with Can508
149. 3tnh: Cdk9/cyclin T in Complex with Can508
150. 3tni: Structure of Cdk9/cyclin T F241L
151. 3tnw: Structure of Cdk2/cyclin a in Complex with Can508
152. 6p3w: Crystal Structure of The Cyclin A-cdk2-orc1 Complex
153. 6o9l: Human Holo-pic in The Closed State
154. 4acm: Cdk2 in Complex with 3-amino-6-(4-{[2-(dimethylamino)ethyl] Sulfamoyl}-phenyl)-n-pyridin-3-ylpyrazine-2-carboxamide
155. 3sw4: Crystal Structure of The Cdk2 in Complex with Thiazolylpyrimidine Inhibitor
156. 3sw7: Crystal Structure of The Cdk2 in Complex with Thiazolylpyrimidine Inhibitor
157. 3ql8: Cdk2 in Complex with Inhibitor Jws-6-260
158. 3qqf: Cdk2 in Complex with Inhibitor L1
159. 3qqg: Cdk2 in Complex with Inhibitor L2-5
160. 3qqh: Cdk2 in Complex with Inhibitor L2-2
161. 3qqj: Cdk2 in Complex with Inhibitor L2
162. 3qql: Cdk2 in Complex with Inhibitor L3
163. 3qrt: Cdk2 in Complex with Inhibitor Nsk-mc2-55
164. 3qru: Cdk2 in Complex with Inhibitor Nsk-mc1-12
165. 3qwj: Cdk2 in Complex with Inhibitor Kvr-1-142
166. 3qwk: Cdk2 in Complex with Inhibitor Kvr-1-150
167. 3qx2: Cdk2 in Complex with Inhibitor Kvr-1-190
168. 3qx4: Cdk2 in Complex with Inhibitor Kvr-1-78
169. 3qxo: Cdk2 in Complex with Inhibitor Kvr-1-84
170. 3qzf: Cdk2 in Complex with Inhibitor Jws-6-52
171. 3qzg: Cdk2 in Complex with Inhibitor Jws-6-76
172. 3qzh: Cdk2 in Complex with Inhibitor Kvr-1-124
173. 3qzi: Cdk2 in Complex with Inhibitor Kvr-1-126
174. 3r1q: Cdk2 in Complex with Inhibitor Kvr-1-102
175. 3r1s: Cdk2 in Complex with Inhibitor Kvr-1-127
176. 3r1y: Cdk2 in Complex with Inhibitor Kvr-1-134
177. 3r28: Cdk2 in Complex with Inhibitor Kvr-1-140
178. 3r6x: Cdk2 in Complex with Inhibitor Kvr-1-158
179. 3r71: Cdk2 in Complex with Inhibitor Kvr-1-162
180. 3r73: Cdk2 in Complex with Inhibitor Kvr-1-164
181. 3r7e: Cdk2 in Complex with Inhibitor Kvr-1-67
182. 3r7i: Cdk2 in Complex with Inhibitor Kvr-1-74
183. 3r7u: Cdk2 in Complex with Inhibitor Kvr-1-75
184. 3r7v: Cdk2 in Complex with Inhibitor Kvr-1-9
185. 3r7y: Cdk2 in Complex with Inhibitor Kvr-2-88
186. 3r83: Cdk2 in Complex with Inhibitor Kvr-2-92
187. 3r8l: Cdk2 in Complex with Inhibitor L3-4
188. 3r8m: Cdk2 in Complex with Inhibitor L3-3
189. 3r8p: Cdk2 in Complex with Inhibitor Nsk-mc1-6
190. 3rai: Cdk2 in Complex with Inhibitor Kvr-1-160
191. 3rm6: Cdk2 in Complex with Inhibitor Kvr-2-80
192. 3rm7: Cdk2 in Complex with Inhibitor Kvr-1-91
193. 3roy: Cdk2 in Complex with Inhibitor Kvr-1-154
194. 3rpo: Cdk2 in Complex with Inhibitor Kvr-1-156
195. 3ti1: Cdk2 in Complex with Sunitinib
196. 3tiy: Cdk2 in Complex with Nsc 35676
197. 3tiz: Cdk2 in Complex with Nsc 111848
198. 4erw: Cdk2 in Complex with Staurosporine
199. 4ez3: Cdk2 in Complex with Nsc 134199
200. 4ez7: Cdk2 in Complex with Staurosporine and 2 Molecules of 8-anilino-1- Naphthalene Sulfonic Acid
201. 4ec8: Structure of Full Length Cdk9 in Complex with Cyclint and Drb
202. 4ec9: Crystal Structure of Full-length Cdk9 in Complex with Cyclin T
203. 4bbm: Crystal Structure of The Human Cdkl2 Kinase Domain with Bound Tcs 2312
204. 6inl: Crystal Structure of Cdk2 in Complex with Inhibitor Cvt-313
205. 3qqk: Cdk2 in Complex with Inhibitor L4
206. 3qtq: Cdk2 in Complex with Inhibitor Rc-1-137
207. 3qtr: Cdk2 in Complex with Inhibitor Rc-1-148
208. 3qts: Cdk2 in Complex with Inhibitor Rc-2-12
209. 3qtu: Cdk2 in Complex with Inhibitor Rc-2-132
210. 3qtw: Cdk2 in Complex with Inhibitor Rc-2-13
211. 3qtx: Cdk2 in Complex with Inhibitor Rc-2-35
212. 3qtz: Cdk2 in Complex with Inhibitor Rc-2-36
213. 3qu0: Cdk2 in Complex with Inhibitor Rc-2-38
214. 3qxp: Cdk2 in Complex with Inhibitor Rc-3-89
215. 3r8u: Cdk2 in Complex with Inhibitor Rc-1-132
216. 3r8v: Cdk2 in Complex with Inhibitor Rc-1-135
217. 3r8z: Cdk2 in Complex with Inhibitor Rc-1-136
218. 3r9d: Cdk2 in Complex with Inhibitor Rc-2-135
219. 3r9h: Cdk2 in Complex with Inhibitor Rc-2-142
220. 3r9n: Cdk2 in Complex with Inhibitor Rc-2-21
221. 3r9o: Cdk2 in Complex with Inhibitor Rc-2-143
222. 3rah: Cdk2 in Complex with Inhibitor Rc-2-22
223. 3rak: Cdk2 in Complex with Inhibitor Rc-2-32
224. 3ral: Cdk2 in Complex with Inhibitor Rc-2-34
225. 3rjc: Cdk2 in Complex with Inhibitor L4-12
226. 3rk5: Cdk2 in Complex with Inhibitor Rc-2-72
227. 3rk7: Cdk2 in Complex with Inhibitor Rc-2-71
228. 3rk9: Cdk2 in Complex with Inhibitor Rc-2-74
229. 3rkb: Cdk2 in Complex with Inhibitor Rc-2-73
230. 3rmf: Cdk2 in Complex with Inhibitor Rc-2-33
231. 3rni: Cdk2 in Complex with Inhibitor Rc-3-86
232. 3rpr: Cdk2 in Complex with Inhibitor Rc-2-49
233. 3rpv: Cdk2 in Complex with Inhibitor Rc-2-88
234. 3rpy: Cdk2 in Complex with Inhibitor Rc-2-40
235. 3rzb: Cdk2 in Complex with Inhibitor Rc-2-23
236. 3s00: Cdk2 in Complex with Inhibitor L4-14
237. 3s0o: Cdk2 in Complex with Inhibitor Rc-1-138
238. 3s1h: Cdk2 in Complex with Inhibitor Rc-2-39
239. 3sqq: Cdk2 in Complex with Inhibitor Rc-3-96
240. 4gcj: Cdk2 in Complex with Inhibitor Rc-3-89
241. 4aua: Liganded X-ray Crystal Structure of Cyclin Dependent Kinase 6 (cdk6)
242. 4bcf: Structure of Cdk9 in Complex with Cyclin T and a 2-amino-4- Heteroaryl-pyrimidine Inhibitor
243. 4bch: Structure of Cdk9 in Complex with Cyclin T and a 2-amino-4- Heteroaryl-pyrimidine Inhibitor
244. 4bci: Structure of Cdk9 in Complex with Cyclin T and a 2-amino-4- Heteroaryl-pyrimidine Inhibitor
245. 4bcj: Structure of Cdk9 in Complex with Cyclin T and a 2-amino-4- Heteroaryl-pyrimidine Inhibitor
246. 4bco: Structure of Cdk2 in Complex with Cyclin a and a 2-amino-4- Heteroaryl-pyrimidine Inhibitor
247. 4bcq: Structure of Cdk2 in Complex with Cyclin a and a 2-amino-4- Heteroaryl-pyrimidine Inhibitor
248. 4eoi: Thr 160 Phosphorylated Cdk2 K89D, Q131E - Human Cyclin A3 Complex with The Inhibitor Ro3306
249. 4eoj: Thr 160 Phosphorylated Cdk2 H84S, Q85M, K89D - Human Cyclin A3 Complex with Atp
250. 4eok: Thr 160 Phosphorylated Cdk2 H84S, Q85M, K89D - Human Cyclin A3 Complex with The Inhibitor Nu6102
251. 4eol: Thr 160 Phosphorylated Cdk2 H84S, Q85M, K89D - Human Cyclin A3 Complex with The Inhibitor Ro3306
252. 4eom: Thr 160 Phosphorylated Cdk2 H84S, Q85M, Q131E - Human Cyclin A3 Complex with Atp
253. 4eon: Thr 160 Phosphorylated Cdk2 H84S, Q85M, Q131E - Human Cyclin A3 Complex with The Inhibitor Ro3306
254. 4eoo: Thr 160 Phosphorylated Cdk2 Q131E - Human Cyclin A3 Complex with Atp
255. 4eop: Thr 160 Phosphorylated Cdk2 Q131E - Human Cyclin A3 Complex with The Inhibitor Ro3306
256. 4eoq: Thr 160 Phosphorylated Cdk2 Wt - Human Cyclin A3 Complex with Atp
257. 4eor: Thr 160 Phosphorylated Cdk2 Wt - Human Cyclin A3 Complex with The Inhibitor Nu6102
258. 4eos: Thr 160 Phosphorylated Cdk2 Wt - Human Cyclin A3 Complex with The Inhibitor Ro3306
259. 4ez5: Cdk6 (monomeric) in Complex with Inhibitor
260. 4i3z: Structure of Pcdk2/cyclina Bound to Adp and 2 Magnesium Ions
261. 4ii5: Structure of Pcdk2/cyclina Bound to Adp and 1 Magnesium Ion
262. 3zdu: Crystal Structure of The Human Cdkl3 Kinase Domain
263. 4au8: Crystal Structure of Compound 4a in Complex with Cdk5, Showing an Unusual Binding Mode to The Hinge Region via a Water Molecule
264. 4bcg: Structure of Cdk9 in Complex with Cyclin T and a 2-amino-4- Heteroaryl-pyrimidine Inhibitor
265. 4bck: Structure of Cdk2 in Complex with Cyclin a and a 2-amino-4- Heteroaryl-pyrimidine Inhibitor
266. 4bcm: Structure of Cdk2 in Complex with Cyclin a and a 2-amino-4- Heteroaryl-pyrimidine Inhibitor
267. 4bcn: Structure of Cdk2 in Complex with Cyclin a and a 2-amino-4- Heteroaryl-pyrimidine Inhibitor
268. 4bcp: Structure of Cdk2 in Complex with Cyclin a and a 2-amino-4- Heteroaryl-pyrimidine Inhibitor
269. 6gzh: Crystal Structure of Human Cdk9/cyclint1 with A86
270. 6gva: Cdk2/cyclin A2 in Complex with Pyrazolo[4,3-d]pyrimidine Inhibitor Lgr4455
271. 6guk: Cdk2 in Complex with CGP74514A
272. 6guh: Cdk2 in Complex with Azd5438
273. 6guf: Cdk2/cyclina in Complex with CGP74514A
274. 6gue: Cdk2/cyclina in Complex with Azd5438
275. 6guc: Cdk2/cyclina in Complex with Su9516
276. 6gub: Cdk2/cyclina in Complex with Flavopiridol
277. 6gu7: Cdk1/cks2 in Complex with Azd5438
278. 6gu6: Cdk1/cks2 in Complex with Dinaciclib
279. 6gu4: Cdk1/cyclinb/cks2 in Complex with CGP74514A
280. 6gu3: Cdk1/cyclinb/cks2 in Complex with Azd5438
281. 6gu2: Cdk1/cyclinb/cks2 in Complex with Flavopiridol
282. 4imy: The Aff4 Scaffold Binds Human P-tefb Adjacent to Hiv Tat
283. 4bgq: Crystal Structure of The Human Cdkl5 Kinase Domain
284. 4ek3: Crystal Structure of Apo Cdk2
285. 4ek4: Crystal Structure of The Cdk2 in Complex with Aminopyrazole Inhibitor
286. 4ek5: Crystal Structure of The Cdk2 in Complex with Aminopyrazole Inhibitor
287. 4ek6: Crystal Structure of The Cdk2 in Complex with Aminopyrazole Inhibitor
288. 4ek8: Crystal Structure of The Cdk2 in Complex with Thiazolylpyrimidine Inhibitor
289. 4f6s: Crystal Structure of Human Cdk8/cycc in Complex with Compound 7 (1-[3- Tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]urea)
290. 4f6u: Crystal Structure of Human Cdk8/cycc in Complex with Compound 5 (1-[3- Tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(morpholin-4-yl) Propyl]urea)
291. 4f6w: Crystal Structure of Human Cdk8/cycc in Complex with Compound 1 (n-[3- Tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-4-[2-({[3-tert-butyl- 1-(4-methylphenyl)-1h-pyrazol-5-yl]carbamoyl}amino)ethyl]piperazine- 1-carboxamide)
292. 4f70: Crystal Structure of Human Cdk8/cycc in Complex with Compound 4 (1-[3- Tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[2-(morpholin-4-yl) Ethyl]urea)
293. 4f7j: Crystal Structure of Human Cdk8/cycc in Complex with Compound 3 (1-[3- Tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(2-hydroxyethyl) Urea)
294. 4f7l: Crystal Structure of Human Cdk8/cycc in Complex with Compound 2 (tert- Butyl [3-({[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5- Yl]carbamoyl}amino)propyl]carbamate)
295. 4f7n: Crystal Structure of Human Cdk8/cycc in Complex with Compound 11 (1- [3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(5- Hydroxypentyl)urea)
296. 4f7s: Crystal Structure of Human Cdk8/cycc in The Dmg-in Conformation
297. 4fkg: Crystal Structure of The Cdk2 in Complex with Aminopyrazole Inhibitor
298. 4fki: Crystal Structure of The Cdk2 in Complex with Aminopyrazole Inhibitor
299. 4fkj: Crystal Structure of The Cdk2 in Complex with Aminopyrazole Inhibitor
300. 4fkl: Crystal Structure of The Cdk2 in Complex with Thiazolylpyrimidine Inhibitor
301. 4fko: Crystal Structure of The Cdk2 in Complex with Thiazolylpyrimidine Inhibitor
302. 4fkp: Crystal Structure of The Cdk2 in Complex with Oxindole Inhibitor
303. 4fkq: Crystal Structure of The Cdk2 in Complex with Oxindole Inhibitor
304. 4fkr: Crystal Structure of The Cdk2 in Complex with Oxindole Inhibitor
305. 4fks: Crystal Structure of The Cdk2 in Complex with Oxindole Inhibitor
306. 4fkt: Crystal Structure of The Cdk2 in Complex with Oxindole Inhibitor
307. 4fku: Crystal Structure of The Cdk2 in Complex with Oxindole Inhibitor
308. 4fkv: Crystal Structure of The Cdk2 in Complex with Oxindole Inhibitor
309. 4fkw: Crystal Structure of The Cdk2 in Complex with Oxindole Inhibitor
310. 4g6l: Crystal Structure of Human Cdk8/cycc in The Dmg-in Conformation
311. 4fx3: Crystal Structure of The Cdk2/cyclin a Complex with Oxindole Inhibitor
312. 3uli: Human Cyclin Dependent Kinase 2 (cdk2) Bound to Azabenzimidazole Derivative
313. 6cyt: Hiv-1 Tar Loop in Complex with Tat:aff4:p-tefb
314. 3wbl: Crystal Structure of Cdk2 in Complex with Pyrazolopyrimidine Inhibitor
315. 6ckx: Structure of Cdk12/cyck in Complex with a Small Molecule Inhibitor N- (4-(1-methyl-1h-pyrazol-4-yl)phenyl)-n-((1r,4r)-4-(quinazolin-2- Ylamino)cyclohexyl)acetamide
316. 4bgh: Crystal Structure of Cdk2 in Complex with Pan-cdk Inhibitor
317. 4bzd: Structure of Cdk2 in Complex with a Benzimidazopyrimidine
318. 4cfn: Structure-based Design of C8-substituted O6-cyclohexylmethoxyguanine Cdk1 and 2 Inhibitors.
319. 4cfw: Structure-based Design of C8-substituted O6- Cyclohexylmethoxyguanine Cdk1 and 2 Inhibitors.
320. 4cxa: Crystal Structure of The Human Cdk12-cyclin K Complex Bound to Amppnp
321. 4kd1: Cdk2 in Complex with Dinaciclib
322. 4krc: Crystal Structure of Pho85-pcl10-atp-gamma-s Complex
323. 4krd: Crystal Structure of Pho85-pcl10 Complex
324. 4lyn: Crystal Structure of Cyclin-dependent Kinase 2 (cdk2-wt) Complex with (2s)-n-(5-(((5-tert-butyl-1,3-oxazol-2-yl)methyl)sulfanyl)-1,3- Thiazol-2-yl)-2-phenylpropanamide
325. 4nj3: Modulating The Interaction between Cdk2 and Cyclin a with a Quinoline- Based Inhibitor
326. 4nst: Crystal Structure of Human Cdk12/cyclin K in Complex with Adp-aluminum Fluoride
327. 4ogr: Crystal Structure of P-tefb Complex with Aff4 and Tat
328. 4or5: Crystal Structure of Hiv-1 Tat Complexed with Human P-tefb and Aff4
329. 5xs2: Cdk8-cycc in Complex with Compound 17:3-chloro-4-(4-pyridyl)-1h- Pyrrole-2-carboxamide
330. 5xqx: Human Cdk8-cycc in Complex with Compound 4: N-methyl-4-(4-pyridyl)-1h- Pyrrole-2-carboxamide
331. 4tth: Crystal Structure of a Cdk6/vcyclin Complex with Inhibitor Bound
332. 4un0: Crystal Structure of The Human Cdk12-cyclink Complex
333. 4rj3: Cdk2 with Egfr Inhibitor Compound 8
334. 5uq3: Crystal Structure of Human Cdk2-spy1-p27 Ternary Complex
335. 5uq2: Crystal Structure of Human Cdk2-spy1 Complex
336. 5uq1: Crystal Structure of Human Cdk2-spy1 Complex
337. 4cfm: Structure-based Design of C8-substituted O6- Cyclohexylmethoxyguanine Cdk1 and 2 Inhibitors.
338. 4cfu: Structure-based Design of C8-substituted O6- Cyclohexylmethoxyguanine Cdk1 and 2 Inhibitors.
339. 4cfv: Structure-based Design of C8-substituted O6- Cyclohexylmethoxyguanine Cdk1 and 2 Inhibitors.
340. 4cfx: Structure-based Design of C8-substituted O6-cyclohexylmethoxyguanine Cdk1 and 2 Inhibitors.
341. 5osm: CDK2(F80C, C177A) with Covalent Adduct at C80
342. 5osj: Cdk2(wt) with Covalent Adduct at C177
343. 5oo3: CDK2(F80C, C177A) with Covalent Ligand at F80C
344. 5oo1: CDK2(F80C, C177A) Covalent Adduct with C37 at F80C
345. 5oo0: Cdk2(wt) Covalent Adduct with D28 at C177
346. 5nev: Cdk2/cyclin a in Complex with Compound 73
347. 5mhq: Cct068127 in Complex with Cdk2
348. 5lqf: Cdk1/cyclinb1/cks2 in Complex with Nu6102
349. 5lmk: Structure of Phopsho-cdk2-cyclin a in Complex with an Atp-competitive Inhibitor
350. 5l2w: The X-ray Co-crystal Structure of Human Cdk2/cycline and Dinaciclib.
351. 5l2t: The X-ray Co-crystal Structure of Human Cdk6 and Ribociclib.
352. 5l2s: The X-ray Co-crystal Structure of Human Cdk6 and Abemaciclib.
353. 5l2i: The X-ray Co-crystal Structure of Human Cdk6 and Palbociclib.
354. 5l1z: Tar Complex with Hiv-1 Tat-aff4-p-tefb
355. 5k4j: Crystal Structure of Cdk2 in Complex with Compound 22
356. 5jq8: Crystal Structure of Cdk2 in Complex with Inhibitor Icec0943
357. 5jq5: Crystal Structure of Cdk2 in Complex with Inhibitor Icec0942
358. 5if1: Crystal Structure Apo Cdk2/cyclin a
359. 5iey: Crystal Structure of a Cdk Inhibitor Bound to Cdk2
360. 5iex: Crystal Structure of (r,s)-s-{4-[(5-bromo-4-{[(2r,3r)-2-hydroxy-1- Methylpropyl]oxy}- Pyrimidin-2-yl)amino]phenyl}-s- Cyclopropylsulfoximide Bound to Cdk2
361. 5iev: Crystal Structure of Bay 1000394 (roniciclib) Bound to Cdk2
362. 5idp: Cdk8-cycc in Complex with (3-amino-1h-indazol-5-yl)-[(s)-2-(4-fluoro- Phenyl)-piperidin-1-yl]-methanone
363. 5idn: Cdk8-cycc in Complex with [(s)-2-(4-chloro-phenyl)-pyrrolidin-1-yl]- (3-methyl-1h-pyrazolo[3,4-b]pyridin-5-yl)-methanone
364. 5icp: Cdk8-cycc in Complex with [(s)-2-(4-chloro-phenyl)-pyrrolidin-1-yl]- (5-methyl-imidazo[5,1-b][1,3,4]thiadiazol-2-yl)-methanone
365. 5i5z: Cdk8-cycc in Complex with 8-(1-methyl-2,2-dioxo-2,3-dihydro-1h-2l6- Benzo[c]isothiazol-5-yl)-[1,6]naphthyridine-2-carboxylic Acid Methylamide
366. 5hvy: Cdk8/cycc in Complex with Compound 20
367. 5hq0: Ternary Complex of Human Proteins Cdk1, Cyclin B and Cks2, Bound to an Inhibitor
368. 5hnb: Cdk8-cycc in Complex with [6-hydroxy-3-(3-methyl-benzyl)-1h-indazol-5- Yl]-((s)-3-hydroxy-pyrrolidin-1-yl)-methanone
369. 5hbj: Cdk8-cycc in Complex with 8-[2-amino-3-chloro-5-(1-methyl-1h-indazol- 5-yl)-pyridin-4-yl]-2,8-diaza-spiro[4.5]decan-1-one
370. 5hbh: Cdk8-cycc in Complex with 5-{5-chloro-4-[1-(2-methoxy-ethyl)-1,8- Diaza-spiro[4.5]dec-8-yl]-pyridin-3-yl}-1-methyl-1,3-dihydro- Benzo[c]isothiazole 2,2-dioxide
371. 5hbe: Cdk8-cycc in Complex with 8-[3-chloro-5-(1-methyl-2,2-dioxo-2, 3- Dihydro-1h-2l6-benzo[c]isothiazol-5-yl)-pyridin- 4-yl]-1-oxa-3,8- Diaza-spiro[4.5]decan-2-one
372. 5g6v: Crystal Structure of The Pctaire1 Kinase in Complex with Inhibitor
373. 5fp6: Structure of Cyclin-dependent Kinase 2 with Small-molecule Ligand 3-(4,7-dichloro-1h-indol-3-yl)prop-2-yn-1-ol (at17833) in an Alternate Binding Site.
374. 5fp5: Structure of Cyclin-dependent Kinase 2 with Small-molecule Ligand 4- Fluorobenzoic Acid (at222) in an Alternate Binding Site.
375. 5fgk: Cdk8-cycc in Complex with 8-[3-(3-amino-1h-indazol-6-yl)-5-chloro- Pyridine-4-yl]-2,8-diaza-spiro[4.5]decan-1-one
376. 5efq: Crystal Structure of Human Cdk13/cyclin K in Complex with Adp-aluminum Fluoride
377. 5d1j: Crystal Structure of Cyclin-dependent Kinase 2 (cdk2-wt) Complex with N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl] Methyl]thio]-2-thiazolyl]- 4-piperidinecarboxamide (bms-387032)
378. 5cyi: Cdk2/cyclin a Covalent Complex with 6-(cyclohexylmethoxy)-n-(4- (vinylsulfonyl)phenyl)-9h-purin-2-amine (nu6300)
379. 5cei: Crystal Structure of Cdk8:cyclin C Complex with Compound 22
380. 5bnj: Cdk8/cycc in Complex with 8-{3-chloro-5-[4-(1-methyl-1h-pyrazol-4-yl)- Phenyl]-pyridin- 4-yl}-2,8-diaza-spiro[4.5]decan-1-one
381. 5ank: Crystal Structure of Cdk2 in Complex with 2,4,6-trioxo-1-phenyl- Hexahydropyrimidine-5-carboxamide Processed with The Crystaldirect Automated Mounting and Cryo-cooling Technology
382. 5anj: Crystal Structure of Cdk2 in Complex with N-(9h-purin-6-yl)thiophene- 2-carboxamide Processed with The Crystaldirect Automated Mounting and Cryo-cooling Technology
383. 5ani: Crystal Structure of Cdk2 in Complex with 6-chloro-7h-purine Processed with The Crystaldirect Automated Mounting and Cryo-cooling Technology
384. 5ang: Crystal Structure of Cdk2 in Complex with 7-hydroxy-4- (morpholinomethyl)chromen-2-one Processed with The Crystaldirect Automated Mounting and Cryo-cooling Technology
385. 5ane: Crystal Structure of Cdk2 in Complex with 6-methoxy-7h-purine Processed with The Crystaldirect Automated Mounting and Cryo-cooling Technology
386. 5acb: Crystal Structure of The Human Cdk12-cyclink Complex
387. 5a14: Human Cdk2 with Type II Inhibitor
388. 4d1x: Cdk2 in Complex with Luciferin
389. 4d1z: Cdk2 in Complex with a Luciferin Derivate
390. 4yc3: Cdk1/cyclinb1/cks2 Apo
391. 4yc6: Cdk1/cks1
392. 4crl: Crystal Structure of Human Cdk8-cyclin C in Complex with Cortistatin a
393. 4y72: Human Cdk1/cyclinb1/cks2 with Inhibitor
394. 6sg4: Structure of Cdk2/cyclin a M246Q, S247EN
395. 7kpv: Structure of Kinase and Central Lobes of Yeast Ckm
396. 7kpx: Structure of The Yeast Ckm
397. 7b5l: Ubiquitin Ligation to F-box Protein Substrates by Scf-rbr E3-e3 Super- Assembly: Nedd8-cul1-rbx1-skp1-skp2-ckshs1-cyclin A-cdk2-p27- UBE2L3~UB~ARIH1. Transition State 1
398. 7b5o: Cryo-em Structure of The Human Cak Bound to Icec0942 at 2.5 Angstroms Resolution
399. 7b5q: Cryo-em Structure of The Human Cak Bound to Icec0942 (PHENIX-OPLS3E)
400. 7b5r: Ubiquitin Ligation to F-box Protein Substrates by Scf-rbr E3-e3 Super- Assembly: Cul1-rbx1-skp1-skp2-ckshs1-cyclin A-cdk2-p27
401. 6y0a: Crystal Structure of Cdk8-cycc in Complex with Bi00690300
402. 7ack: Cdk2/cyclin A2 in Complex with an Imidazo[1,2-c]pyrimidin-5-one Inhibitor
403. 7e34: Crystal Structure of Sun1-speedy A-cdk2
404. 7nvr: Human Mediator with Rna Polymerase II Pre-initiation Complex
405. 6twn: Crystal Structure of Talin1 R7R8 in Complex with Cdk1 (206-223)
406. 7nxj: Crystal Structure of Human Cdk13/cyclin K in Complex with The Inhibitor Thz531
407. 7nxk: Crystal Structure of Human Cdk12/cyclin K in Complex with The Inhibitor Bsj-01-175
408. 7nvq: Aerosol-soaked Human Cdk2 Crystals with Staurosporine
409. 7kjs: Crystal Structure of Cdk2/cyclin E in Complex with Pf-06873600
410. 7m2f: Cdk2 with Compound 14 Inhibitor with Carboxylate
411. 7b7s: Cdk2/cyclin A2 in Complex with 3h-pyrazolo[4,3-f]quinoline-based Derivative Hsd1368
412. 7nj0: Cryoem Structure of The Human Separase-cdk1-cyclin B1-cks1 Complex
413. 6w9e: Crystal Structure of Human Cdk9/cyclint1 in Complex with Mc180295
414. 7nwk: Crystal Structure of Cdk9-cyclin T1 Bound by Compound 6
415. 7ra5: Cdk2 in Complex with Compound 4